Ohio State Navbar


Recent News

Heart Failure and Sleep-Disordered Breathing — The Plot Thickens

September 17, 2015

Central sleep apnea occurring within the cyclic breathing pattern of Cheyne–Stokes respiration has been reported to be common in patients with heart failure.1 During sleep, episodes of hyperventilation followed by a complete cessation (apnea) or decrease (hypopnea) in breathing are associated with oxyhemoglobin desaturations, arousals, and sympathetic nervous system activation that could be deleterious to the failing heart. Thus, suppression of central sleep apneas and hypopneas seemed to be a reasonable target in the treatment of patients with heart failure.

Cowie et al.2 now describe in the Journal the results of the SERVE-HF (Treatment of Sleep-Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure) trial, which investigated the effects of adding adaptive servo-ventilation to guideline-based medical treatment on survival and cardiovascular outcomes in patients with a left ventricular ejection fraction of 45% or less and predominantly central sleep apnea. Adaptive servo-ventilation unexpectedly resulted in increased cardiovascular mortality.

Click here for entire article


Treatment of Sleep Apnea Results in Greater Blood Pressure Reduction in Those with Resistant Hypertension

Released: April 3, 2015

Columbus, Ohio - A new meta-analysis conducted by an international team of sleep and respiratory researchers suggests that untreated sleep apnea may be a major factor in why medications appear to be less effective in reducing high blood pressure in some people. Further, the study shows that continuous positive airway pressure (CPAP) therapy may be the key to helping those with difficult to treat hypertension get their blood pressure under control.

Click here for entire article

International Sleep Apnea Genetics Group Pushes Boundaries of Biomedical Informatics

Source: The Ohio State University Center for Clinical and Translational Science

COLUMBUS, OHIO - As more and more data indicate that sleep apnea is linked with cardiovascular disease, stroke, diabetes and even an increase in deaths related to car accidents, an international consortium spanning five continents is working together to unravel the genetic basis for the condition.

From a scientific discovery standpoint, researchers in the Sleep Apnea Genetics International Consortium (SAGIC) are embarking on a massive undertaking. Considering those researchers are working in seven different time zones, the amount of biomedical information the group is intending to gather, combine and analyze, becomes even more remarkable.  Ulysses Magalang, MD, Director of the Sleep Disorders Center at The Ohio State University Wexner Medical Center, is featured in the story.
(Click here for complete story)

SAGIC Research Article: (click here)

Sleep Apnea Plus Dim Light at Night Increases Depression, Anxiety in Mice


Sleep Apnea Prediction Tool Identifies Individuals Who are Ideal Candidates for Home Sleep Testing