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Ulysses J. Magalang, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: magalang.1@osu.edu

 

Current OSU Appointments

Professor-Clinical, Pulmonary, Crit Care, & Sleep

Professor, SBS-Neuroscience

Physician, FGP-Pulm, Crit Care, & Sleep

 

Clinical Interest

Sleep Disorders

Pulmonary Consultation

Advising Narrative

Won the Outstanding Research Poster Presentation (Undergraduate category) 4th Annual Pulmonary Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, November 17, 2009.
Second Place Winner, 2010 Denman Undergraduate Research Forum (Health Professions - Laboratory/Cellular ), The Ohio State University

Published Works

Manuscripts in Preparation (Project Completed):

1.Mice Over-expressing Adiponectin Are Protected Against Insulin Resistance Induced by Intermittent Hypoxia.
2.Continuous Hypoxia Suppresses High-Molecular-Weight Adiponectin Secretion by Adipocytes.
3.Measurement of Intracellular Oxygen Tension in Adipocytes during Intermittent Hypoxia: An Electron Paramagnetic Resonance Study

Research Funding

1.INTERMITTENT HYPOXIA, ADIPONECTIN, AND INSULIN RESISTANCE IN CARDIOVASCULAR RISK.1R01 HL093463-01Role: Principal Investigator (Multiple PI: Magalang, Parinandi)Sponsoring organization: National Institutes of Health (NHLBI)Dates: 12/01/2009-11/30/2014Total grant support: $1,875,000.00 Priority Score: 27 (11th percentile) Status: pending, council review completedWe are waiting for the funding notification from the Program Director, but believe that the proposal received a fundable score (11th percentile).

Master/Graduate Advising

Andrew Ray, February 1, 2006 (Ph.D. thesis defense at State University of New York at Buffalo). “The effects of intermittent hypoxia on upper airway mechanics in experimental obesity.” Mr. Andrew Ray’s thesis was chosen by the Dean of Graduate School, State University of New York at Buffalo for an Outstanding Dissertation Award.

Academic Advising

2004 - present , The Ohio State University.
2007 - present , The Ohio State University.
2008 - present Muzzammil Sayyid, The Ohio State University. Continuous Hypoxia Decreases Adiponectin Secretion by Adipocytes Through Activation of the Unfolded Protein Response
2004 - 2006 Andrew Ray, State University of New York - University at Buffalo. Graduated 2006. "The effects of intermittent hypoxia on upper airway mechanics in experimental obesity"
2009 - 2010 Muzzammil Sayyid, The Ohio State University. Graduated 2010. Continuous Hypoxia Decreases Adiponectin Secretion through Activation of the UPR
2009 - 2011 Kapil Dhawan, The Ohio State University. Graduated 2011.
 

Licenses

1996 - present Medical License: State Medical Board of New York
1997 - present Board Certification: American Board of Sleep Medicine
2003 - present Medical License: State Medical Board of Ohio
2004 - present Board Recertification: American Board of Internal Medicine
2004 - present Board Recertification: American Board of Internal Medicine
2005 - present Board Recertification: American Board of Internal Medicine
2007 - present Board Certification: American Board of Internal Medicine
 

Chapters in Books

Behavioral and pharmacologic therapy of obstructive sleep apnea

Monitoring respiration during sleep

Noninvasive monitoring of gas exchange during sleep

Adipokines and Sleep Disorders

 

Clinical Services

01/01/2004 Attending, Sleep Medicine Clinics
01/01/2004 Attending, Sleep Disorders Center -Polysomnography Interpretation (University Hospital East)
01/01/2004 Sleep Medicine Call (University Hospital East)
08/01/2009 Block Coverage of the James Consult, Ross Consult, MICU, OSU East, 8ICU, and Risk/PFT Services (OSU Main, Ross, James, and OSU East Medical Centers)
02/01/2004 MICU B (MICU)
03/01/2004 OSU East (OSU East)
05/01/2004 MICU B (MICU)
09/01/2004 UH Consults (OSU Medical Center)
12/01/2004 MICU A (MICU)
03/01/2005 OSU East (OSU East)
04/01/2005 OSU East (OSU East)
07/01/2005 Ross Consults (Ross Heart Hospital)
12/01/2005 MICU 40-45 (MICU)
01/01/2006 UH Consults (OSU Medical Center)
05/01/2006 MICU 40-45 (MICU)
11/01/2006 Ross Consults (Ross Heart Hospital)
12/01/2006 James Consults (James Cancer Hospital)
02/01/2007 Ross Consults (Ross Heart Hospital)
04/01/2007 James Consults (James Cancer Hospital)
07/01/2007 Ross Consults (Ross Heart Hospital)
02/01/2008 Ross Consults (Ross Heart Hospital)
05/01/2008 James Consults (James Cancer Hopsital)
10/01/2008 James Consults (James Cancer Hospital)
12/01/2008 James Consults (James Cancer Hospital)
02/01/2009 James Consults (James Cancer Hospital)
05/01/2009 James Consults (James Cancer Hospital)
07/01/2009 Ross Consults (Ross Heart Hospital)

Degrees

1979 B.S., University of the Philippines

1983 M.D., University of the Philippines

 

Edited Books

Respiratory Disorders and Sleep

 

Editorial Activities

1991 - 1993 American Review of Respiratory Disease
2002 American Journal of Respiratory and Critical Care Medicine
2003 - 2007 Chest
2007 Lung
2009 - present Redox Report
2009 - present 2010 American Thoracic Society International Conference
2009 - present Laboratory Investigation
2011 - present Sleep
2011 - present American Journal of Pathology
2011 - present Journal of Applied Physiology
2012 - present American Journal of Regul Integr Comp Physiol
2012 - present American Journal of Physiology- Cell Physiology
2012 - present ISRN Obesity
 

Honors

2005 America's Best Doctors. bestdoctors.com.
2006 America's Best Doctors. bestdoctors.com.
2007 America's Best Doctors. bestdoctors.com.
2008 America's Best Doctors. bestdoctors.com.
2009 America's Best Doctors. bestdoctors.com.
2010 America's Best Doctors. bestdoctors.com.
2011 America's Best Doctors. bestdoctors.com.
2012 America's Best Doctors. bestdoctors.com.
 

Journal Articles

 

Reference Works

January 1991 Mador MJ, Magalang UK, Kufel TJ."Low frequency diaphragmatic fatigue following exercise in normal man" . : A365
January 1992 Mador MJ, Kufel TJ, Magalang UJ."Effect of hyperoxia on diaphragmatic fatigue following cycle exercise in normal subjects" . : A149
January 1993 Mador MJ, Magalang UJ, Rodis AR, Shah Z."Reproducibility of the Borg scale measurement of breathlessness in patients with COPD" . : A547
January 1993 Mador MJ, Magalang UJ, Kufel TJ."Twitch potentiation following voluntary diaphragmatic contraction" . : A699
January 1994 Magalang UJ, Grant BJB."Determination of gas exchange threshold by nonparametric regression" . : A777
January 1994 Mador MJ, Rodis A, Ameen K, Magalang UJ."Comparison of cervical magnetic and transcutaneous phrenic nerve stimulation before and after threshold loading" . : A129
January 1996 Magalang UJ, Kelemen GS, Seeds KM, Schwab RJ."The incidence and reproducibility of sleep arousals in normal subjects" . : 91
January 1996 Magalang UJ, Okabe S, Kubin L."Microinjection of the TRH analogue MK-771 into the rat hypoglossal nucleus induces a biphasic excitation" . : 16
January 2000 El-Solh A, Magalang UJ, Mador MJ, Dmochowski, Veeramachaneni S, Draw A, Lieber BB, Grant BJB."The utility of oximetry in the diagnosis of patients with Cheyne-Stokes respiration: a novel approach" . : A356
January 2000 Nakano H, Magalang UJ, Lee S, Krasney JA, Farkas GA."Serotonergic modulation of ventilation and upper airway stability in obese Zucker rats" . : A543
January 2000 Magalang UJ, Nakano H, Najdzionek J, Lee S, Farkas GA."Obese Zucker rats have narrower and more collapsible upper airway compared to lean litter-mates" . : A87
January 2001 Magalang UJ, Dmochowski J, Veeramachaneni S, Mador MJ, El-Solh A, Draw A, Grant BJB."Prediction of the apnea-hyponea index using multiple adaptive regression splines" . : A386
January 2002 Magalang UJ, Ray AD, Farkas GA."Effects of hypoglossal nerve stimulation on upper airway mechanics inobese zucker rats" . : A798
January 2003 Magalang UJ, Divani A, Ogasa T, Megirian D, Farkas GA."A method to detect upper airway obstruction in unanesthetized rats" . : A798
January 2004 Mador MJ, Rajesh RSK, Watwe VR, Magalang UJ, Grant BJB."Incidence of positional sleep apnea in patients undergoing polysomnography" . : A543
January 2004 Ogasa T, Farkas GA, Michlin CP, Ray AD, Magalang UJ."Effects of age on rat upper airway collapsibility" . : A431
January 2004 Ray AD, Ogasa T, Michlin CP, Farkas GF, Magalang UJ."Effects of intermittent hypoxia on upper airway mechanics in rats" . : A431
January 2004 Ogasa T, Farkas GA, Michlin CP, Ray AD, Magalang UJ."Effects of serotonergic agonist on upper airway mechanics in obese Zucker rats" . : A431
January 2004 Grant B, Divani A, Azzam K, Magalang U."Measurement frequency response of pulse oximeters" . : A369
January 2005 Magalang UJ, Colligan E, Alvarado-Valdes C, Archana M, Hershey CO, Grant BJB."Utility of a sleep disorders questionnaire for primary care providers" . : A328
January 2005 Ray AD, Ogasa T, Michlin CP, Farkas GF, Magalang UJ."Effects of Chronic Intermittent Hypoxia on Upper Airway Collapsibility in Lean and Obese Zucker Rats" . : A609
January 2005 Grant BJB, Choi Y, Colligan E, Bhatt A, Mishra A, Magalang UJ, Hershey CO."Identification of sleep symptom complexes inpatients attending primare care clinics" . : A328
January 2006 Grant B, Choi Y, Sathanathan A, Magalang UJ, Grant GB, El-Solh AA."Model drift in a questionnaire that predicts severity of obstructive sleep apnea" . : A210
January 2006 Gregory A, Kuppusamy E, Steinhour E, Baran CP, Rajappan R, Magalang UJ, Kuppusamy P, Romberger D, Marsh CB, Parinandi NL."Swine farm particulate matter is a potent stimulator of reactive oxygen species formation by macrophages" . : A653
January 2006 Magalang UJ, Rajappan R, Varadharaj S, Hunter MG, Kutala VK, Kuppusamy P, Wewers M, Marsh CB, Parinandi NL."Adiponectin inhibits superoxide generation by human neutrophils" . : A353
January 2006 Magalang UJ, Varadharaj S, Steinhour E, Hunter MG, Watkins T, Baran CP, Kuppusamy P, Zweier JL, Marsh CB, Natarajan V, Parinandi N."Redox active antioxidant activities phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases" . : A308
January 2008 Sherwani S, Liaugminas A, Varadharaj S, Kuppusamy P, Magalang UJ, Marsh C, Parinandi N.."Lipoxygenase inhibitor, NDGA, induces formation of lipid signal mediator phosphatidic acid in lung endothelila cells." . : A928
January 2008 Cruff JP, Rajappan R, Patel T, Marsh CB, Parinnadi N, Magalang UJ."Intermittent hypoxia suppresses adiponectin secretion by adipocytes." . : A269
January 2008 Cruff JP, Mador MJ, Raman SV, McCarthy B, Rajappan R, Tridandapani S, Essig L, Marsh CB, Parinandi N, Magalang UJ."CPAP treatment increases levels of high-molecular-weight adiponectin in patients with obstructive sleep apnea." . : A269
January 2008 Hinzey A, Kline M, O’Connor Butler, Magalang UJ, Marsh C, Parinandi N.."Cyclodextrin-assisted membrane cholesterol removal induces barrier dysfunction in lung endothelial cells: role of lipid rafts in cytoskeleton." . : A856
January 2008 Magalang UJ, Richards K, McCarthy B, Khan M, Fathala A, Parinnadi P, Raman SV.."Magnetic resonance study of the effects of CPAP on cardiac structre and function in patients with obstructive sleep apnea." . : A856
January 2008 Kline M, Hinzey A, O’Connor Butler, Wewers M, Magalang UJ, Marsh C, Parinandi N.."Lipid raft cholesterol is vital for lung vascular endothelial cell viability." . : A848
January 2009 U.J. Magalang, J.P. Cruff, S.I. Sherwani, M.Hunter, D. Dakhlallah, C.B. Marsh, N.D. Parinandi."Continuous Hypoxia Suppresses High-Molecular-Weight Adiponectin Secretion by Adipocytes" . : A5345
January 2009 U.J. Magalang, A.E. Bratasz, J.P. Cruff, S.I. Sherwani, N.L. Parinandi, C.B. Marsh, P. Kuppusamy."Measurement of Intracellular Oxygen Tension in Adipocytes During Intermittent Hypoxia: An Electron Paramagnetic Resonance Study" . : A1070
January 2010 Dhawan, K; Sherwani, SI; Sayyid, MM; Aldana, C; Parinandi, NL; Magalang, UJ."Effects of Intermittent Hypoxia on Glucose Tolerance in Female TALLYHO/JngJ Mice" .
January 2010 Magalang, UJ; Cruff, JP; Sherwani, SI; Sayyid, M; Dakhlallah, D; Piper, M; Scherer, P; Parinandi, N."Transgenic Mice Overexpressing Adioponectin Are Protected Against Insulin Resistance Induced by Intermittent Hypoxia" .
January 2011 Aldana, C; Sherwani, SI; Kotha, S; Butler, Dhawan, K; Parinandi, N; Magalang, UJ."Effects of Intermittent Hypoxia on Glucose Tolerance and Total Fatty Acids in the Hyperinsulinemic Male Tallyho/jngi Mice" .
January 2011 Magalang, UJ; Chen, N, Cistulli, P; Fedson, A; Gislason, T; Hillman, D; Penzel, T; Tamisier, R; Tufik, S; Pack AI for the SAGIC Investigators."Agreement in the Scoring of Respiratory Events and Sleep Among International Sleep Centers" .
January 2011 Sherwani, SI; Aldana, C; Sayyid, M; Piper, M; Dakhlallah, D; Scherer, P; Parinandi, N; Magalang, UJ."Continuous Hypoxia Suppresses Adiponectin Secretion by Adipocytes through Activation of the Unfolded Protein Response" .
January 2011 Asif, MJ; Closser, DR, Magalang, UJ; Bhatt, N."Young Women with Shortness of Breath and Holes in Her Lungs" .
January 2011 Aldana, C; Sherwani, SI; Dhawan, K; Usmani, M; Parinandi, N; Magalang, UJ."Intermittent Hypoxia Reduces Adiponectin Secretion by Visceral White Adipose Tissue" .
January 2011 Kotha, S; Gregory, A; Steinhour, E; Baran, C; Magalang, UJ; Romberger, DJ; Parinandi, NL."Agricultural Organic Particulate Matter Stimulates Reactive Oxygen Species Formation and Thiol-Redox-Dependent Interleukin-8 Release by Macrophages" .
January 2012 Iftikhar, I; Khan, M; Durkin, M; Das, M; Blankfield, R; Magalang, UJ."Meta-Analysis: Continuous Positive Airway Pressure Therapy Improves Insulin Resistance in Patients with Obstructive Sleep Apnea" .
January 2012 Asif, M; Chacey, M; Russell, C; Kynyk, J; Goodman, L; Magalang, UJ."Analysis of Interpretation Practices of Cardiopulmonary Exercise Tests: A Quality Initiative" .
January 2012 Magalang, UJ; Sherwani, SI; Aldana, C; Usmani, S; Parinandi, N; Kotha, S; Eubank, T; Baran, C."Intermittent Hypoxia Induces Pancreatic Beta-Cell Dysfunction in a Mouse Model of Type 2 Diabetes Mellitus" .
January 2012 Teferra, R; Afaq, T; Iftikhar, I; Dhawan, K; Khan, M; Grant, BJB; Magalang, UJ."Likelihood Ratios for Clinical Predictions of Obstructive Sleep Apnea Using AASM Polysomnography Scoring Rules" .
January 2013 Magalang, UJ, Sherwani, SI, Usman, S, Parinandi, N."Intermittent Hypoxia Increases Splicing of X-Box-Binding Protein 1 in the Adipose Tissue of a Mouse Model of Type 2 Diabetes Mellitus" .
June 2013 Ajaz, F, Mindel, J, Onadeko, O, Aliling, J, Khan, M, Das, A, Bhatt, N, Magalang, U."Relationship Between Hours of CPAP Use and Daytime Function Beyond Three Months" .
January 2013 Eubank, T, Sherwani, S, Peters, S, Gross, A, Evans, R, Magalang, U."Intermittent Hypoxia Augments Melanoma Tumor Metastases in a Mouse Model of Sleep Apnea" .
January 2013 Mindel, J, Ajaz, F, Teferra, R, Afaq, T, Iftikhar, I, Khan, M, Das, A, Grant, BJB, Magalang, U."An Artificial Neural Network Sleep Apnea Prediciton Tool for In-Home and In-Lab Polysomnography" .

Softwares

October 2008 Multi-Media."Researchers Find Possible Heart Disease, Sleep Apnea Link"
June 2008 Multi-Media."Ohio State Sleep Experts Seek Sleep Apnea, Diabetes Link"
October 2008 Multi-Media."Researchers Find Possible Heart Disease, Sleep Apnea Link"
November 2008 Multi-Media."A New Link Between Sleep Apnea and Heart Disease"
July 2008 Multi-Media."Desperately Seeking Shut-Eye"
November 2008 Multi-Media."Researchers Find Potential Heart Disease, Sleep Apnea Link"
January 2009 Multi-Media."Guest Editor for Respiraoty/Sleep Medicine Issue"
March 2009 Multi-Media."Treatment for Sleep Apnea Can Reduce Heart Size"
February 2009 Multi-Media."Treatment for Sleep Apnea Can Reduce Heart Size"
February 2009 Multi-Media."Treatment for Sleep Apnea Can Reduce Heart Size"

Presentations

Sleep Architecture in the Various Sleep Disorders

Sleep Disorders: Recognition and Management

Sleep Disorders: Recognition and Management

Sleep Disorders: Recognition and Management

CPAP Treatment Increases Levels of High-Molecular-Weight Adiponectin in Patients with Obstructive Sleep Apnea

Restless Legs Syndrome and Parasomnias

The Drowsy Worker

Measurement of Intracellular Oxygen Tension in Adipocytes During Intermittent Hypoxia

Hypoxia, Adiponectin, and the Unfolded Protein Response

Cardiac Structure and Function OSA: Effects of CPAP Therapy

Relationships Between Obesity, Diabetes, and Sleep Apnea

Obesity and Sleep Apnea; Role of Adipokines

When Pulmonary and Critically Ill Patients are Obese, Organizer and Chair

Hypoxia, Adiponectin, and Respiratory Disorders

Hypoxia

Obstructive Sleep Apnea as a Systemeic Disorder

Controversies in Sleep Medicine: Is a Sleep Study Indicated?

Sleep Disordered Breathing and Metabolic Function: How Unsweet It Is

The Sleepy Patietn: What to do if There is No Sleep Apnea

Agreement in the Scoring of Respiratory Events and Sleep Among International Sleep Centers

Adiponectin Protects Against Hyperoxic Lung Injury and Vascular Leak

Sleep deprivation attenuates endotoxin-induced cytokine gene expression independent of day length and circulating cortisol in male Siberian hamsters (Phodopus sungorus)

Intermittent Hypoxia Suppresses Adiponectin Secretion by Adipocytes

 

Professional Activities

present Course Director, May 2007.