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Rami Khayat, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: khayat.3@osu.edu

 

Current OSU Appointments

Professor-Clinical, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep

 

Clinical Interest

Sleep medicine and critical care medicine

Continuing Education, Extension, and Other Courses Taught

Sleep disordered breathing and cardiovascular disease:

European Respiratory Society; London 2017; invited lecture and session facilitator

American Thoracic Society Denver 201; session facilitator

international Heart Failure Society of America 2013



Sleep Heart fellowship (2009-2013):

Academic Advising

Undergraduate:

Masters

Ph.D

Advising Narrative

Several students presented in national and international conferences and co-authored papers. Each student accomplishment is detailed in the related list of students.

Academic Advising

2007 - present Brian Patt, The Ohio State University.
2008 Qihui Liu, The Ohio State University. Graduated 0.
2011 Robert Dohar, The Ohio State University. Graduated 0.
2011 Saradhadevi Varadharaj, The Ohio State University. Graduated 0.
2014 Adam Pleister,, The Ohio State University. Graduated 0.
2006 - 2008 Monica , The Ohio State University.
2007 - 2008 Meena Khan, The Ohio State University. Graduated 0.
2007 - 2008 Robin Trupp, The Ohio State University. Graduated 2008.
2007 - 2008 Troy Schaffernocker, The Ohio State University.
2007 - 2008 Kiran Devulapaly, The Ohio State University.
2006 - 2009 Michael Powers, The Ohio State University.
2007 - 2009 Joshua Gestosani, The Ohio State University.
2007 - 2009 Raymond Pongonis, The Ohio State University.
2008 - 2009 Meena Khan, The Ohio State University.
2007 - 2010 Diane Haddad, The Ohio State University. Graduated 0.
2009 - 2011 Jarrod Bruce, The Ohio State University. Graduated 2012.
2010 - 2011 Jenny Hessieh, The Ohio State University. Graduated 0.
2008 - 2012 Jacob Wannemacher, The Ohio State University. Graduated 2012.
2010 - 2012 Donald Kikta, The Ohio State University. Graduated 2012.
 

Licenses

1999 - present Board Certification: American Board of Internal Medicine
2003 - present Medical License: State Medical Board of Ohio
2004 - present Board Certification: American Board of Sleep Medicine
2009 - present Board Recertification: American Board of Medical Specialties
2011 - present Board Recertification: American Board of Internal Medicine
2012 - present Board Recertification: American Board of Internal Medicine
1998 - 2003 Medical License: State of Wisconsin Medical Board
2002 - 2011 Board Certification: American Board of Internal Medicine
2003 - 2012 Board Certification: American Board of Internal Medicine
 

Chapters in Books

Monitoring Respiration During Sleep

Sleep-related breathing disorders and acute heart failure syndrome

Sleep Apnea and Heart Failure

 

Clinical Services

01/01/2004 OSUE inpatient service (OSUE hospital)
01/01/2004 Pulmonary and Critical Care inpatient service (OSUMC, Internal Medicine)
01/01/2004 - 10/01/2009 Outpatient Sleep Medicine clinics and test interpretation (OSUE hospital; Ross heart hospital; Martha Morehouse Medical Plaza, Internal medicine)

Degrees

1988 None Indicated, National Orthodox College

1994 M.D., Tishreen University

 

Editorial Activities

2006 - present Lung
2006 - 2008 Journal of Cardiac Failure
2007 - present European Heart Journal
2007 International Journal of COPD
2007 - 2008 Heart Failure Reviews
2008 Antioxidants & Redox Signaling
2008 Journal of Respiratory Diseases
2009 - present Journal of the American College of Cardiology (JACC)
2010 - present Population Health Science and Health Service Research; Republic of Ireland
2010 - present International Journal of Cardiology
2012 - present Chest
2014 - present Sleep and Breathing
2014 - present UpToDate; Sleep Medicine Section
2015 - present Chest
 

Honors

1988 - present Honor List. Lattakia Directorship of Education.
1989 - present Recognition of Outstanding Academic Achievement and Scholarship. The Roman Orthodox Archdiocese, Lattakia, Syria.
1989 - 1996 Dean's List. Tishreen University Faculty of Medicine, Lattakia, Syria.
1994 - present Rating of Excellence. Tishreen University-Faculty of Medicine.
1999 - present Resident Evaluation Committee Recognition. Department of Medicine.
2002 - 2003 National Research Service Award. National Heart, Lung, and Blood Institute.
2009 - present The OSU-Davis Bremer and NIH Center for Clinical and Translational Science (CCTS) at OSU (CCTS) Award. OSU.
 

Journal Articles

"Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apnea." CHEST. Vol. 123, no. 5. (May 2003.): -.

"Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans." JOURNAL OF APPLIED PHYSIOLOGY. Vol. 97, no. 2. (August 2004.): -.

"Sleep-disordered breathing in patients with decompensated heart failure." HEART FAILURE REVIEWS. Vol. 14, no. 3. (September 2009.): -.

"Endothelial nitric oxide synthase uncoupling: A novel pathway in OSA induced vascular endothelial dysfunction." RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. Vol. 207, (February 2015.): -.

 

Reference Works

January 1999 Rami N. Khayat, Daling Zhu, and Elizabeth RJacobs."Chronic hypoxia induces epoxyeicosatrienoic acids (EETS) in neonatal rabbit lungs" .
January 2002 Rami N. Khayat, MD, Ailiang Xie PhD, and James Skatrud, MD."The ventilatory and cardiovascular effects of dead space in patients with CHF-CSA" .
January 2003 Xie, R.N. Khayat, D.S. Puleo, B.J. Morgan, J.B. Skatrud."Cerebrovascular Response to CO2 in Patients with Congestive Heart Failure" .
January 2003 Rami N. Khayat, Barbara Morgan, James Skatrud, and Jerry Dempsey."The role of pulmonary stretch reflex in neurocirculatory response to apnea" .
January 2004 A. Xie, R. Khayat, J.A. Dempsey, B. Chenuel, J.H. Lin, J.B. Skatrud."Effect of Cerebrovascular Reactivity to CO2 on the Hypercapnic Ventilatory Response" .
September 2007 R . Khayat , B . Patt , T . Yamokoski , W . Abraham."Obstructive Sleep Apena May Play a Role in the Acute Decompensation of Heart Failure" . : S172-S172
January 2007 RN Khayat, D Jarjoura, B Patt, WT Abraham."Comparison between CPAP and BIPAP for the Treatment of OSA in Patients with Chronic Systolic Heart Failure" .
June 2008 Brian Patt B.S. Jian Sun PhD , Jay Zweier MD , Arturo Cardounel PhD, Stephen Schutzman B.S., Rami Khayat MD."Endothelial Dysfunction in Obstructive Sleep Apnea and The Role of Endogenous Inhibitors Of Nitric Oxide" .
June 2008 Rami Khayat, Brian Patt, Stephen Schutzman, David Jarjoura, and William Abraham."Role of Obstructive Sleep Apnea in the Acute Decompensation of Heart Failure" .
April 2008 R. N. Khayat, S. J. Schutzman, B. T, Patt, , S. Roy, G. Gordillo, R. Schlanger, L. Lambert, K. Rose, U. Gnyawali, A. Coston and C. K. Sen."Prevalence of Obstructive Sleep Apnea In Patients of an Academic Wound Center" . : A10–A58
January 2008 Rami N Khayat, Brian Patt, Roger Holt, Xiaoxue Fan, Min Pu."Beneficial Effects of Continuous Positive Airway Pressure on LV Diastolic Function in Patients with Congestive Heart Failure and Obstructive Sleep Apnea" .
January 2008 B. Patt, R. N. Khayat, , S. Roy, G. Gordillo, R. Schlanger, L. Lambert, & C. K. Sen."Risk Factors and Role of Obstructive Sleep Apnea in Patients with Chronic Non-Healing Wounds" .
September 2009 Javaheri S, Goetting M, Khayat RN, Goodwin J, Wyle P."The ability of auto servo ventilation to eliminate complex central sleep apnea" .
June 2009 Haddad, D., Patt, B.,Yearsley, K., Khayat, R.."Oxidative Stress and Endothelial Dysfunction in Patients with Obstructive Sleep Apnea" .
January 2009 Brian Patt, Lynn Lambert, Sashwati Roy, Gayle Gordillo, Richard Schlanger, & Chandan. K. Sen, Rami Khayat."Validation of Obstructive Sleep Apnea Screening of Patients in an Academic Wound Center" .
January 2010 Ponikowski P, Zhang SJ, Witkowski T, Hasan A, Khayat RN, Bart B, Jagielski D, Zhang X."Central Sleep Apnea Events are Terminated by Phrenic Nerve Stimulations" . : E289
May 2010 J. Wannemacher, B. Patt, R. Khayat."The Inflammatory Response in OSA and its Relation to Endothelial Dysfunction" .
June 2010 Khayat RN, et al.."A Novel Approach Using Phrenic Nerve Stimulation to Treat Central Sleep Apnea: First-In-Man Experience" .
May 2010 B. Patt, M. Powers, J. Wannemacher, R. Khayat."Central Sleep Apnea Predicts Post-Discharge Readmission in Patients with Decompensated Heart Failure" .
November 2012 Saradhadevi Varadharaj Jacob Wannemacher, Brian Patt, Hemalatha Rao, Levy Reyes, Jay L Zweier, Rami Khayat."eNOS uncoupling leads to endothelial dysfunction in clinical Obstructive Sleep A pnea (OSA) : Role of BH4 depletion" .
November 2012 ."" .
September 2013 Angela Sow, Robert Dohar, Brittany Mantia, Matthew Lahman, William Abraham, Rami Khayat.."Sleep Disordered Breathing Is an Independent Predictor of One Month Readmission in Decompensated Heart Failure Hospitalizations" .
March 2013 Campbell, L, Best, J, Khayat, RN, Splaingard, M."Issues Applying a Math Model to Estimate Continuous Positive Airway Pressure Response in Cheyne-Stokes Respiration" . : 553
September 2013 Angela Sow, Robert Dohar, Brittany Mantia, Matthew Lahman, William Abraham, Rami Khayat."Sleep Disordered Breathing as an Independent Predictor of Post-Discharge Mortality in Patients with Acutely Decompensated Heart Failure" .

Presentations

Treatment of CHF-CSA

Thromboembolic Disease in the ICU

Pathophysiology and Treatment of Cheyne-Stokes Respiration

The Neurocirculatory Consequences of Sleep Apnea

Strategies for Liberation from Mechanical Ventilation

Practical Approach to Sleep Apnea and Heart Failure

Tight Glycemic Control in the Hospital Setting- A second look

Endocrine issues in the ICU

The Cardiovascular Consequences of Sleep Apnea

The OSU Sleep Heart Program-a vital merger of two specialties

Obstructive Sleep Apnea and Chronic Non-Healing Wounds

Sleep and Sleepiness for the Artist

Sleep Disordered Breathing in the Hospitalized Patient with Cardiovascular Disease

The Cardiovascular Consequences of Obstructive Sleep Apnea

Obstructive Sleep Apnea: Presentation and Management for the Respiratory Therapist

Obstructive Sleep Apnea and Wound Healing - An Important Co-morbidity

Healthy Hearts

Anemia in ICU

Sleep Disordered Breathing for the Respiratory Therapist

Obstructive Sleep Apnea: What does the primary care physician need to know?

Novel Approach to the Treatment of Central Sleep Apnea

OSA in the Operating Room: Approach to patients with OSA in the pre-operative area

Sleep Disordered Breathing and Heart Failure

Sleep Heart ACC summit

OSA and Cardiovasular Metabolic Risk

Sleep and Cardiovascular Diseases "Summit"

The Cardiovascular Consequences of Sleep Apnea

Sleep Disordered Breathing: A Novel Target in the Management of Decompensated Heart Failure

Detection and Diagnosis of Central Sleep Apnea

Sleep Disordered Breathing in Heart Failure: A Target for Improved Outcomes

Sleep Disordered Breathing- Update on Diagnosis and Treatment

Sleep Medicine, Speaker

Thematic Poster Presentations on Outcomes of Sleep Disordered Breathing and Sleep Loss; Lead facilitator

 

Professional Activities

2005 - present Consultant to Biomedical Company. Respironics, Inc.
2007 - present Consultant to Biomedical Company. Cardiac Concepts, Inc.
2007 - present Consultant to Biomedical Company. Widemed - GE, Israel.
2008 - present Davis Heart and Lung Research Institute Annual Research Retreat and Abstract Competition. Davis Heart and Lung Research Institute.
2010 - present Davis/Bremer Research Fund. OSU Center for Clinical and Translational Science.
2012 - present Reviewer. Population Health Science and Health Service Research Health Research Board, Republic of Ireland.
2013 - present Reviewer. NIH Pathway to Independence K99/K22 ZHL1 CSR-P.
2015 - present Special Emphasis Panel/Scientific Review Group 2015/05 ZHL1 CSR-I (M1). NIH.
2015 - present Lung Section. American Heart Association.
2015 - present reviewer. NIH Infectious Disease, Reproductive Health, and Asthma/Pulmonary Conditions (IRAP) study section.
2006 Student Research Scholarship Applications. Ohio State University.
2009 Reviewed Grands Submitted to the Foundation. Kentucky Science and Engineering Foundation Grant.
2009 - 2010 Student Research Scholarship Applications. Ohio State University.
2006 - 2012 Public and Patient Education. Net Wellness.