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Narasimham L. Parinandi, PhD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-8577

Email: parinandi.3@osu.edu

 

Current OSU Appointment

Associate Professor, Pulmonary, Crit Care, & Sleep

 

Biographical

Narasimham Parinandi (Pari) is currently an associate professor of internal medicine and pharmacology at the Ohio State University College of Medicine, Columbus, OH, USA. Pari received his PhD in Biology and Toxicology from the University of Toledo, Toledo, OH, USA in 1986 under the tutelage of Prof. Woon Jyung, an authority on zinc metabolism in plants. During doctoral training, Pari specialized in bio-inorganic chemistry and interaction of trace metals with membrane lipids in brain. Pari had undergone post-doctoral training at the Hormel Institute (Mecca of Lipid Research) of the University of Minnesota, Austin, MN in Membrane Lipid Biochemistry and Lipid Oxidation Chemistry from 1986-1990 under the mentorship of Prof. Harald Schmid, a world-renowned expert on plasmalogen and anandamide chemistry. Following that, he was an editor of toxicology and biochemistry and information scientist at the CAS of the American Chemical Society in Columbus, OH, USA. Pari was a junior faculty at the Johns Hopkins University School of Medicine, Baltimore, MD where he worked on oxidant lipid signaling in the division of pulmonary & critical care medicine during 1998-2002 under the mentorships of Prof. Skip Garcia and Prof. V. Natarajan, who are celebrities in vascular endothelial biology and signaling. In 2002, Pari joined the Division of Pulmonary & Critical Care Medicine of the OSU College of Medicine as an assistant professor and has established the Lipid Signaling, Lipidomics, and Vasculotoxicity program at the Davis Heart & Lung Research Institute of the Ohio State University. Pari’s research focus is on Phospholipid Signalases in Lung Vasculature, Lipidomics of Adiposity, and Bioactive Oxidant Lipidomics in Vasculotoxicity. Pari has published over 70 papers in peer-reviewed journals. Pari has been one of the editors of the Journal of Glycomics and Lipidomics. Pari’s passion is to train young scientists, bridging between clinician and basic scientists, and is dedicated to education and training. Pari has trained over 50 young researchers and has been awarded the Outstanding Mentor Awards of the DHLRI and OSU Undergraduate Program.

Advising Narrative

Agriculture/Environmental Science

Books

Spirulina - A Blue-Green Alga with Novel Therapeutic Actions

 

Chapters in Books

Drug-induced nephrotoxicity protection by Spirulina

Spirulina - A Blue-green Alga with Novel Therapeutic Actions

Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A(2), lipoxygenase, and cyclooxygenase

Lipoxygenase-catalyzed phospholipid peroxidation: preparation, purification, and characterization of phosphatidylinositol peroxides.

 

Degrees

1980 M.S., Berhampur University

1986 Ph.D., University of Toledo

 

Edited Books

Free Radicals and Antioxidant Protocols (Methods in Molecular Biology)

 

Editorial Activities

1989 Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
1989 - 1990 Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
2007 Antioxidants and Redox Signaling
2007 Lipids
2007 American Journal of Respiratory Cell and Molecular Biology
2007 American Journal of Physiology Cell Biology
2007 Journal of Lipid Research
2007 Chemistry & Physics of Lipids
2007 Progress of Lipid Research
 

Honors

1975 Bachelor of Science with Honors and Distinction.
1975 - 1977 Post-Graduate Gold Medal Award.
1975 - 1977 National Merit Scholarship. Government of India.
1979 - 1980 Junior Research Fellowship. Council of Scientific and Industrial Research.
1986 Outstanding Teaching Assistant Award. Department of Biology.
1994 - 1996 Recognition. Chemical Abstracts Service, Columbus, Ohio.
1997 - 1998 Recognition-Quality Assurance Program. Chemical Abstracts Service, Columbus, Ohio.
1997 - 1998 Recognition. American Chemical Society, Columbus Chapter.
2009 - present 2009 Distinguished Undergraduate Research Mentor Award. Undergraduate Research Office.
 

Journal Articles

 

Presentations

Catecholamines as Model Systems to Study Metal-induced Free Radical Oxidations

Antioxidants for Vanadium-induced Lipid Peroxidation in the Rat Brain in vitro

Trace Metal-induced Lipid Peroxidation in Rat Brain and Mechanisms

Vanadium-induced Lipid Peroxidation in the Rat Brain

Lipid Peroxidation - Fact or Fiction

Free Radicals - Biology, Biochemistry and Toxicity

Biochemican and Molecular basis of Circadian Rhythms

Diabetic Heart and Kidney exhibit Increased Resistance to Oxidative Stress

Lipid Peroxidation in Sciatic Nerve during Ischemia and Reperfusion

Mechanisms of Vanadium-induced Free Radical-mediated Lipid Peroxidation in Rat Brain

Oxidative Stress and Lipid Peroxidation in Myocardium

Involvement of Src Kinase in Oxidant-mediated Activation of Phospholipase D in Vascular Endothelial Cells

Signal Transduction and Kinases

NAD[P]H Oxidase-mediated Generation of Reactive Oxygen Species during Hyperoxia in Vascular Endothelial Cells

Particulate Matter Respiratory Toxicity - Present State

Role of Phospholipase D in Urban Particulate Matter-induced Interleukin-8 Secretion by Bronchial Epithelial Cells

Phospholipase and Protein Kinase Network in Pulmonary Endothelial Cell Oxidant Signaling

Oxidant Activation of Phospholipase D in Vascular Endothelium and Respiratory Tract Epithelium

Electron Paramagnetic Resonance Spectroscopic Analysis of Lipid Peroxidation

Signaling mechanisms of agricultural dust-induced inflammatory cytokine release by respiratory tract epithelial cells

Redox-active antioxidant-mediated Lipid Signaling

Lipidomics of phospholipase cross-talk in vascular endothelium

Agricultural Particulate matter-induced inflammatory cytokine secretion regulation by A2 in lung epithelial cells

Nitric oxide-mediated lipid signaling in the vascular endothelium and the barrier dysfunction

Phospholipase D, a Redox-Sensitive Lipid Signalase in Lung Endothelial Cells, Regulates Vascular Permeability and Vasculotoxicity.

Metals, Oxidative Stress, Antioxidants and Vascular Endothelium

Lipid Oxygenases Regulate Phospholipase D activation Under Redox Modulation in Endothelial Cells

Mercury-induced Vasculotoxicity and Impairment of Angiogenesis

Mercury-induced Lipid Signaling - A membrane Basis for Mercury Toxicity

How to Evolve as a Successful Scientist

Adipose Tissue Protects Against Hyperoxic Lung Damage

Novel Sulfhydryl Protective Compound for Leaky Gut Syndrome

Intermittent Hypoxia Suppresses Adiponectin Secretion by Adipocytes

 

Professional Activities

2006 Ohio State University Pulmonary Division Grant Review.
2006 AHA Grant-in-Aid Review.