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Mikhail Gavrilin, PhD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-8945

Email: gavrilin.1@osu.edu

 

Current OSU Appointment

Research Assistant Professor, Pulmonary, Crit Care, & Sleep

 

Chapters in Books

Expresión de los genes de hormona de crecimiento, variantes moleculares y acciones biológicas de estas variantes

Animal Models of Retroviral Encephalopathies: Feline Model.

Animal Models of Retroviral Encephalopathies: Feline Model.

 

Conferences

Glucocorticoid reception in liver of rats living in the radiocontaminated regions and under the hypo-function of thyroid gland

Mechanisms of glucocorticoid action on cell level

Steroid hormone reception during low doses gamma-irradiation

Intracellular cycle of corticosteroid receptors

The level and reception of the steroid hormones during the low doses irradiation (external, internal and combined).

Rat liver glucocorticoid reception during internal and combined irradiation

Influence of radioecological situation, internal, external and combined irradiation on the binding of the dexamethasone with the rat spleen lymphocytes

Influence of low doses irradiation on the Gomel residents health

Stimulation of glucocorticoid-binding activity in lymphoid cells of rats after irradiation with low doses

Postirradiational disorders in the system of nuclear reception of the thyroid hormones

Molecular mechanisms of the low doses irradiation influence on regulation of the intracellular glucocorticoid reception

The content of natural killer cells subpopulation in the peripheral blood of the Gomel provincia habitants

Glucocorticoid reception in the tissues with different radiosensitivity of animals living in the nearest Chernobyl area

100. Gavrilin MA, Luksha GL. Influence of the internal and combined irradiation on the glucocorticoid reception in rat liver

Complex medical examination of habitants living in the radiocontaminated regions of the Republic of Belarus

Intracellular hormone reception after irradiation

Influence of the combined low doses irradiation on the intracellular glucocorticoid reception

Glucocorticoid function of an organism and irradiation

Variantes moleculares de GH generados en higado

Procesamiento alternativo en la sintesis hepatica de hGH

The hepatic metabolism of Growth Hormone

Procesamiento metabolico nuclear de GH in vitro

The influence of gamma-irradiation on the state of adrenal cortex, thyroid gland and glucocorticoid reception in cytosol of rat liver

Assesment of glutamate transporter expression during feline immunodeficiency virus infection in cats

Methamphetamine enhances FIV-MD replication in feline astrocytes

Methamphetamine enhances lentiviral replication in a feline astrocyte cell lineage

Multiple Psychostimulants Enhance FIV-MD Replication and CXCR4 Expression in Feline Astrocytes During Cell-Associated Infection

Effect of Feline Immunodeficiency Virus and Methamphetamine on the Expression of the Astrocytic Glutamate Transporter GLT-1

Monocyte IKB alpha/NFKBP50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)

HIV-1 infects differential human lung epithelial cells from the basolateral surface and requires galactosylceramid

A Novel Quantitation of Endotoxin Induced Gene Expression without External Standards

HIV-1 Infection of the Human Lung Epithelium by Free Virus and Cell-to-Cell Contact

Monocyte IkB alpha/NFkBp50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)

infection of monocytes by Francisella activates inflammasome complex

Intracellular activation of the human monocyte inflammasome by Francisella

Tyrosine 82 in CARD domain of caspase-1 negatively regulates caspase-1 activation

Monocyte mRNA expression in pediatric multiple organ dysfunction syndrome (MODS)

Monocyte mRNA expression in early septic shock

Pyrin expression is suppressed with monocyte to macrophage differentiation

Stromal gene expression in mediastinal lymph nodes of sarcoidosis patients

Monocyte inflammasome mRNA expression and survival from septic shock

Anti-apoptotic peptide humanin suppressed in monocytes of septic patients

Monocytes and macrophages differ in response to Francisella. A potential regulatory role for pyrin

Gavrilin MA, Bouakl IJ, Knatz NL, Duncan MD, Hall MW, Gunn JS, Wewers MD. Internalization and phagosome escape required for Francisella to induce human monocyte IL-1β processing and release

Pyrin, a product of the familial Mediterranean fever gene (MEFV), is associated with IL-1beta processing and release by mononuclear cells infected with Francisella

Pyrin (MEFV) is associated with IL-1β processing and release by mononuclear cells infected with Francisella

Pyrin levels in human monocytes and monocyte derived macrophages regulate IL-1 beta processing and release

Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion

MAIL (IkBzeta) is a key upstream regulator of monocyte IL-6 production

Real Time PCR array modifications allows accurate and inexpensive gene expression evaluation of critically ill patients

Pyrin regulates Francisella-induced IL-1β processing and release

The Stage-Specific Effect of Interleukin-1 Beta (IL-1 beta) during Human Natural Killer Cell Development

Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion

Smokin’ ICE: Cigarette Smoke Extract Supresses Inflammasome In Peripheral Blood Monocytes Production

Mail (IkBz) is a key regulator of IL-6 production in response to IL-1β and TLR signaling

Macrophages are not monocytes in pathogen responses: role of pyrin

Smokin’ICE: Cigarette smoke extract suppresses inflammasome in peripheral blood monocytes production

Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion

Pyrin’s role in endotoxin and Francisella induced IL-1β processing

Real Time PCR array modifications allows accurate and inexpensive gene expression evaluation of critically ill patients

Macrophages and Monocytes Play a Different Role in Pathogen Response

How caspase-7 controls intracellular infection in macrophages

Colocalization of ASC, Caspase-1, and Pyrin Supports Existence of a Pyrin Inflammasome

Cigarette Smoke Extract Suppresses Innate Immune Response in Peripheral Blood Monocytes.

Pyrin enhances IL-1β processing and release in response to Francisella

Allelic mRNA expression imbalance in inflammation related genes

Role of ASC in Legionella pneumophilla infection

How Caspase-7 Controls Intracellular Infection in Macrophages

Role of ASC in Legionella pneumophilla infection

Cigarette Smoke Extract Supresses Innate Immune Response In Peripheral Blood Monocytes

Control of Mycoplasma contamination in the laboratory

Pyrin Enhances IL-1β Processing and Release in Response to Francisella

Role of pyrin inflammasome in IL-1β processing in response to Francisella

Correlation of inflammatory BAL biomarkers with pulmonary function testing in HIV+ smokers

Caspase-7 activation by the IPAF inflammasome restricts Legionella pneumophila infection

Pyrin assembles with ASC and caspase-1 in response to pathogens

Role of ASC in Legionella pneumophilla infection

Mycoplasma contamination suppresses cells responses to pathogens

Pyrin: Unique role in human detection of Francisella

 

Editorial Activities

2006 - present DHLRI Intramural Thematic Grant Program
2007 - present DHLRI Intramural Thematic Grant Program
2009 - present Health Research Bord, Ireland
2009 - present PLoS One
2010 - present The Ohio State University College of Medicine Medical Student Research Scholarship
2010 - present Frontiers in Cellular and Infection Microbiology
2010 - present Chemical Biology & Drug Design
2012 - present World Journal of Immunology
2012 - present Dataset Papers in Immunology
2012 - present SAGE Open
2012 - present Journal of Proteome Research
2012 - present Journal of Inflammation
2012 - present European Journal of Pharmacology
2013 Flanders Research Foundation, Belgium
 

Honors

1985 - present Diplomat of All Soviet-Union Student Olympiad in Biology.
1985 - present First Place Award in Belarus National Student Olympiad in Biology.
1989 - present Award for the Best Research among Young Scientists. Institute of Radiobiology, Belarus Academy of Sciences, Minsk, Belarus.
1995 - present Academic Merit Award to Visiting Professors. Santiago de Compostela University, Spain.
2006 Best Research Scientist Poster Award. DHLRI.
 

Journal Articles

 

Presentations

Consequences of the Chernobyl Catastrophe

Growth Hormone Receptors

Methamphetamine Enhances FIV-MD Replication in Feline Astrocytes

Multiple Psychostimulants Enhance FIV-MD Replication and CXCR4 Expression in Feline Astrocytes during Cell-Associated Infection

Methamphetamine and some other Psychostimulants Enhance FIV-MD Replication in Feline Astrocytes

Real Time PCR Array Based on Relative Quantification

Polymerase Chain Reaction

Monocytes and Macrophages Differ in Response to Francisella. A Potential Regulatory Role of Pyrin

Gene Delivery: Cell Biology Tools (Aka: MAGic Tools)

Pyrin, a product of the familial Mediterranean fever gene (MEFV), is associated with IL-1beta processing and release by mononuclear cells infected with Francisella

Chernobyl: 20 years later

Some Art at the DHLRI – State of the Art

Radiation. Effects: Benefits and Danger

Real Time PCR Array Based on Relative Quantification

New Type of Inflammasome – the Pyrin Inflammasome

The PAPAs of the Pyrin Inflammasome

New Type of Intracellular Pathogens Sensor – the Pyrin Inflammasome

Application of the OpenArray Inflammatory Platform

Critical Players of the Innate Immunity

Evolution of PCR: from mili to nano in 25 years

Inflammasome Update

Real-Time PCR - Theory and Practice

Role of Pyrin Inflammasome in IL-1ß Processing in Response to Burkholderia cepacia

Chernobyl 25th Anniversary. Lesson from Chernobyl for Japan

Pyrin Critical to Macrophage IL-1 beta Response to Francisella Challenge

A novel P2X(7) receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release

Mycoplasma Suppression of THP-1 Cell TLR Responses Is Corrected with Antibiotics

Francisella recognition by inflammasomes: differences between mice and men

Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1 beta processing and release

Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis

 

Professional Activities

2001 - present Society for Neuroscience. San Diego, CA.
2005 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2006 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2006 - present Pulmonary Research Day. The Ohio State University. Columbus, OH.
2007 - present School of Medicine Research Day. The Ohio State University. Columbus, OH.
2007 - present Pulmonary Research Day. The Ohio State University. Columbus, OH.
2007 - present CMIB Research Retreat. Columbus, OH.
2007 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2008 - present CMIB Research Retreat. The Ohio State University. Columbus, OH.
2008 - present Pulmonary Research Day. The Ohio State University. Columbus, OH.
2009 - present Pulmonary Research Day. Columbus, OH.
2009 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2010 - present School of Medicine Research DAy. The Ohio Sate University. Columbus, OH.
2010 - present CMIB Research Retreat. The Ohio State University. Columbus, OH.
2011 - present DHLRI Research Day. Columbus, OH.
2002 6th International Feline Retrovirus Research Symposium. Amelia Island, FL.
2003 2nd Anual Symposium on the Functional Genomics of Critical Illness and Injury. NIH. Bethesda, MO.
2003 International Meeting of the Institute of Human Virology. Baltimore, MD.
2005 Innate Immunity to Pathogens. Keystone Symposia. Steamboat Springs, CO.
2006 Innate Immunity. Keystone Symposia. Banff, AB.
2007 American Thoracic Society. San Francisco, CA.
2008 American Thoracic Society. Toronto, ON.
2008 Innate Immunity: Signaling Mechanisms. Keystone Symposia. Keystone, CO.
2009 6th International Conference on Tularemia.
2010 Innate Immunity: Mechanisms Linking with Adaptive Immunity. Keystone Symposia.
2011 10th World Congress on Inflammation.
2011 Chernobyl 25th Anniversary. Lesson from Chernobyl for Japan. The Ohio State University.
2011 Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases. Denver, CO.