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Megan Ballinger, PhD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-6578

Email: ballinger.103@osu.edu

 

Current OSU Appointment

Research Assistant Professor, Pulmonary, Crit Care, & Sleep

 

Degrees

1999 B.Land.Arch., University Of Akron

2002 A.A.S., University of Toledo

2007 B.F.A., University of Michigan Ann Arbor

 

Honors

1998 - 2002 University of Toledo Academic Scholarship. University of Toledo.
2000 Sullivan Research Fellowship. ..
2002 Graduate of University of Toledo Honors College. University of Toledo.
2005 Rackham Travel Grant. ..
2005 The Miller Fund Award for Innovative Immunology Research. ..
2008 - 2009 Research Fellow for the Hartwell Foundation. Hartwell Foundation.
2009 Keystone Symposium Scholarship Winner. ..
2010 Internal Medicine Research Day Abstract Finalist. ..
2012 Parker B. Francis Fellow. ..
 

Journal Articles

Ojielo, CI, Cooke, K, Mancuso, P, Standiford, TJ, Olkiewicz, KM, Clouthier, S, Corrion, L, Ballinger, MN, Towes, GB, Paine, R 3rd, Moore, BB. "Defective Phagocytosis and Clearance of Pseudomonas Aeruginosa in the Lung Following Bone Marrow Transplantation." JOURNAL OF IMMUNOLOGY. Vol. 171, no. 8. (October 2003.): 4416-4424.

Rex, E, Molitor, SC, Hapiak, V, Xiao, H, (Henderson) Ballinger, M, Komuniecki, R. "Tyramine Receptor (SER-2) Isoforms are Involved in the Regulation of Pharyngeal Pumping and Foraging Behavior in Caenorhabditis Elegans." J. Neurochem. Vol. 91, (January 2004.): 1104-1115.

Moore,B,B; Ballinger,M,N; White,E,S; Green,M,E; Herrygers,A,B; Wilke,C,A; Toews,G,B; Peters-Golden,M. "Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E-2." JOURNAL OF IMMUNOLOGY. Vol. 174, no. 9. (May 2005.): 5644-5649.

Ballinger,Megan,N; Paine,Robert; Serezani,Carlos,HC; Aronoff,David,M; Choi,Esther,S; Standiford,Theodore,J; Toews,Galen,B; Moore,Bethany,B. "Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 34, no. 6. (June 2006.): 766-774.

Lindell,Dennis,M; Ballinger,Megan,N; McDonald,Roderick,A; Toews,Galen,B; Huffnagle,Gary,B. "Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection." INFECTION AND IMMUNITY. Vol. 74, no. 8. (August 2006.): 4538-4548.

Lindell,Dennis,M; Ballinger,Megan,N; McDonald,Roderick,A; Toews,Galen,B; Huffnagle,Gary,B. "Immunologic homeostasis during infection: Coexistence of strong pulmonary cell-mediated immunity to secondary Cryptococcus neoformans infection while the primary infection still persists at low levels in the lungs." JOURNAL OF IMMUNOLOGY. Vol. 177, no. 7. (October 2006.): 4652-4661.

Ballinger,Megan,N; Aronoff,David,M; McMillan,Tracy,R; Cooke,Kenneth,R; Olkiewicz,Krystyna; Toews,Galen,B; Peters-Golden,Marc; Moore,Bethany,B. "Critical role of prostaglandin E-2 overproduction in impaired pulmonary host response following bone marrow transplantation." JOURNAL OF IMMUNOLOGY. Vol. 177, no. 8. (October 2006.): 5499-5508.

Serezani,Carlos,H; Chung,Jooho; Ballinger,Megan,N; Moore,Bethany,B; Aronoff,David,M; Peters-Golden,Marc. "Prostaglandin E-2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 37, no. 5. (November 2007.): 562-570.

Ballinger,Megan,N; McMillan,Tracy,R; Moore,Bethany,B. "Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation." ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. Vol. 55, no. 1. (February 2007.): 1-12.

Aronoff,David,M; Peres,Camila,M; Serezani,Carlos,H; Ballinger,Megan,N; Carstens,Jennifer,K; Coleman,Nicole; Moore,Bethany,B; Peebles,R,Stokes; Faccioli,Lucia,H; Peters-Golden,Marc. "Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities." JOURNAL OF IMMUNOLOGY. Vol. 178, no. 3. (February 2007.): 1628-1634.

Ballinger,Megan,N; Hubbard,Leah,LN; McMillan,Tracy,R; Toews,Galen,B; Peters-Golden,Marc; Paine,Robert; Moore,Bethany,B. "Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 295, no. 1. (July 2008.): L114-L122.

Hubbard,Leah,LN; Ballinger,Megan,N; Wilke,Carol,A; Moore,Bethany,B. "Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant." EXPERIMENTAL LUNG RESEARCH. Vol. 34, no. 5. (June 2008.): 263-275.

Serezani,Carlos,H; Ballinger,Megan,N; Aronoff,David,M; Peters-Golden,Marc. "Cyclic AMP - Master regulator of innate immune cell function." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 39, no. 2. (August 2008.): 127-132.

Lee,Sang,Pyo; Serezani,Carlos,H; Medeiros,Alexandra,I; Ballinger,Megan,N; Peters-Golden,Marc. "Crosstalk between Prostaglandin E-2 and Leukotriene B-4 Regulates Phagocytosis in Alveolar Macrophages via Combinatorial Effects on Cyclic AMP." JOURNAL OF IMMUNOLOGY. Vol. 182, no. 1. (January 2009.): 530-537.

Sagana,Rommel,L; Yan,Mei; Cornett,Ashley,M; Tsui,Jessica,L; Stephenson,David,A; Huang,Steven,K; Moore,Bethany,B; Ballinger,Megan,N; Melonakos,Janet; Kontos,Christopher,D; Aronoff,David,M; Peters-Golden,Marc; White,Eric,S. "Phosphatase and Tensin Homologue on Chromosome 10 (PTEN) Directs Prostaglandin E-2-mediated Fibroblast Responses via Regulation of E Prostanoid 2 Receptor Expression." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 284, no. 47. (November 2009.): 32264-32271.

Hubbard,Leah,LN; Ballinger,Megan,N; Thomas,Peedikayil,E; Wilke,Carol,A; Standiford,Theodore,J; Kobayashi,Koichi,S; Flavell,Richard,A; Moore,Bethany,B. "A Role for IL-1 Receptor-Associated Kinase-M in Prostaglandin E-2-Induced Immunosuppression Post-Bone Marrow Transplantation." JOURNAL OF IMMUNOLOGY. Vol. 184, no. 11. (June 2010.): 6299-6308.

Ballinger,Megan,N; Standiford,Theodore,J. "Postinfluenza Bacterial Pneumonia: Host Defenses Gone Awry." JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. Vol. 30, no. 9. (September 2010.): 643-652.

Ballinger,Megan,N; Welliver,Timothy; Straight,Samuel; Peters-Golden,Marc; Swanson,Joel,A. "Transient Increase in Cyclic AMP Localized to Macrophage Phagosomes." PLOS ONE. Vol. 5, no. 11. (November 2010.): e13962-.

Bhan,Urvashi; Ballinger,Megan,N; Zeng,Xianying; Newstead,Michael,J; Cornicelli,Matthew,D; Standiford,Theodore,J. "Cooperative Interactions between TLR4 and TLR9 Regulate Interleukin 23 and 17 Production in a Murine Model of Gram Negative Bacterial Pneumonia." PLOS ONE. Vol. 5, no. 3. (March 2010.): e9896-.

Bhan,Urvashi; Newstead,Michael,J; Zeng,Xianying; Ballinger,Megan,N; Standiford,Louis,R; Standiford,Theodore,J. "Stachybotrys chartarum-Induced Hypersensitivity Pneumonitis Is TLR9 Dependent." AMERICAN JOURNAL OF PATHOLOGY. Vol. 179, no. 6. (December 2011.): 2779-2787.

Ballinger,Megan,N; Peters-Golden,Marc; Moore,Bethany,B. "Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2." RESPIRATORY RESEARCH. Vol. 12, (December 2011.): 155-.

Morato-Marques,Mariana; Campos,Marina,R; Kane,Steve; Rangel,Ana,P; Lewis,Casey; Ballinger,Megan,N; Kim,Sang-Hoon; Peters-Golden,Marc; Jancar,Sonia; Serezani,Carlos,H. "Leukotrienes Target F-actin/Cofilin-1 to Enhance Alveolar Macrophage Anti-fungal Activity." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 33. (August 2011.): 28902-28913.

Ballinger,Megan,N; Newstead,Michael,W; Zeng,Xianying; Bhan,Urvashi; Horowitz,Jeffrey,C; Moore,Bethany,B; Pinsky,David,J; Flavell,Richard,A; Standiford,Theodore,J. "TLR Signaling Prevents Hyperoxia-Induced Lung Injury by Protecting the Alveolar Epithelium from Oxidant-Mediated Death." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 1. (July 2012.): 356-364.

Kovach,Melissa,A; Ballinger,Megan,N; Newstead,Michael,W; Zeng,Xianying; Bhan,Urvashi; Yu,Fu-Shin; Moore,Bethany,B; Gallo,Richard,L; Standiford,Theodore,J. "Cathelicidin-Related Antimicrobial Peptide Is Required for Effective Lung Mucosal Immunity in Gram-Negative Bacterial Pneumonia." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 1. (July 2012.): 304-311.

Serezani,C,Henrique; Kane,Steve; Medeiros,Alexandra,I; Cornett,Ashley,M; Kim,Sang-Hoon; Marques,Mariana,Morato; Lee,Sang-Pyo; Lewis,Casey; Bourdonnay,Emilie; Ballinger,Megan,N; White,Eric,S; Peters-Golden,Marc. "PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE(2)-Mediated Inhibition of Phagocytosis of Fungi." SCIENCE SIGNALING. Vol. 5, no. 210. (February 2012.): ra12-.

Standiford,Louis,R; Standiford,Theodore,J; Newstead,Michael,J; Zeng,Xianying; Ballinger,Megan,N; Kovach,Melissa,A; Reka,Ajaya,K; Bhan,Urvashi. "TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 302, no. 5. (March 2012.): L447-L454.

Bhan,Urvashi; Newstead,Michael,J; Zeng,Xianying; Podsaid,Amy; Goswami,Moloy; Ballinger,Megan,N; Kunkel,Steven,L; Standiford,Theodore,J. "TLR9-Dependent IL-23/IL-17 Is Required for the Generation of Stachybotrys chartarum-Induced Hypersensitivity Pneumonitis." JOURNAL OF IMMUNOLOGY. Vol. 190, no. 1. (January 2013.): 349-356.

 

Presentations

"Characterization of Caenorhabditis elegans Octopamine/Tyramine Receptors." Presented at National Conference for Undergraduate Research, Whitewater. (April 2002)

"Upregulation of Prostaglandin E2 Post-Bone Marrow Transplantation Inhibits PUlmonary Host Responses to Pseudomonas Aeruginosa." Presented at American Thoracic Society Conference, San Diego. (May 2005)

"Eicosanoid Regulation of Innate Immunity Post-Bone Marrow Transplantation." Presented at American Thoracic Society Conference, San Diego. (May 2006)

"Eicosanoid Regulation of Host Defense Post-Bone Marrow Transplantation." Presented at Immunocompromised Host-Society, Crans-Montana, CH|CHE. (July 2006)

"PGE2-Induced Immunosuppression Post-Bone Marrow Transplantation: Potential Role of IRAK-M." Presented at American Thoracic Society Conference, San Francisco. (May 2007)

"The Role of Cyclic AMP Compartmentalization in Mediating PGE2 Signaling in Alveolar Macrophages." Presented at Keystone Symposium: Complex Lipids in Biology, Lake Tahoe. (April 2009)

"The Role of Cyclic AMP Compartmentalization in Mediating PGE2 Signaling in Alveolar Macrophages." Presented at American Thoracic Society Conference, San Diego. (May 2009)

"Prostaglandin E2 Mediates Impaired Host Defense Functions in Alveolar Macrophages from Young Rats." Presented at American Thoracic Society Conferences, San Diego. (May 2009)

"The Role of IRAK-M in Mediating Acute Lung Injury." Presented at American Thoracic Society Conference, New Orleans. (May 2010)

"The Role of an Important Negative Regulator of Toll-like Receptor Signaling, IRAK-M, in Mediating." Presented at American Thoracic Society International Meeting, . (May 2011)

"The TLR Signaling Inhibitor IRAK-M Potentiates Bleomycin-Induced Lung Injury and Fibrosis." Presented at American Thoracic Society Conference, San Francisco. (May 2012)

 

Professional Activities

2000 - 2001 University of Salford Exchange Program.
2002 Representative, Honors Program. University of Toledo.
2003 Zambia Medical Mission Team.
2003 - 2004 Representative, Program in Biomedical Science. University of Michigan.
2004 Zambia Medical Mission Team.
2004 Student Mentor. PIBS.
2005 - 2006 Program Chair, Immunology Student Association. Immunology Student Association.
2008 - 2010 Leader, Immunology Post-Doctoral Association.
2009 - 2012 Board Member, University of Michigan Post-Doctoral Association.
2010 - 2012 President, University of Michigan Post-Doctoral Association.
2011 - 2012 Mentor for Undergraduate Student- Jacqueline Neagos.
2008 - 2013 Committee Member, Graduate Student Affairs Committee.
2009 - 2013 Committee Member, American Thoracic Society: Allergy, Immunology, and Inflammation Assembly Membership Committee. American Thoracic Society.
2010 - 2013 Committee Member, American Thoracic Society: Allergy, Immunology, and Inflammation Assembly Planning Committee.
2013 Committee Member, President's Advisory Committee on Women's Issues.
 

Unpublished Works

Ballinger, M, Standiford, T. Innate Immune Responses in Ventilator Associated Pneumonia. January 2013.