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Matthew Exline, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: exline.16@osu.edu

 

Current OSU Appointments

Associate Professor-Clinical, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep

 

Clinical Interest

Asthma

Critical Care

Sepsis

Pulmonary infections including tuberculosis and nontuberculous mycobacterium and fungal infections

Creative Works

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Biographical

I came to Ohio State for residency after matriculating from the University of Nevada in 2000. After my residency in Internal Medicine and fellowship in Pulmonary, Critical Care, and Sleep I joined the Department of Internal Medicine as an Assistant Professor on the clinical track in 2006 as a clinician scholar.

Academic Advising

2013 - present , The Ohio State University.
2011 Sindhu Mukku, The Ohio State University. Graduated 0.
2012 Joseph Duffy, The Ohio State University. Graduated 0.
2007 - 2009 Leanne Strack, The Ohio State University. Graduated 2009.
2008 - 2010 Eric Adkins, The Ohio State University. Graduated 2010.
2009 - 2012 Michael Chacey, The Ohio State University. Graduated 2012.
 

Licenses

2003 - present Medical License: State Medical Board of Ohio
2003 - present Internal Medicine: American Board of Internal Medicine
2005 - present Pulmonary Disease: American Board of Internal Medicine
2006 - present Critical Care: American Board of Internal Medicine
2007 - present Fundamentals of Critical Care Support: Society of Critical Care Medicine
2011 - present Sleep Medicine: American Board of Internal Medicine
2012 - present Difficult Airway Management: A Critical Care Approach: American College of Chest Physicians
2014 - present Advanced Cardiac Life Support (ACLS): The Ohio State University
2004 - 2007 Advanced Trauma Life Support: The Ohio State University
 

Chapters in Books

Crouser, ED, Exline, M, Fahy, RJ. "Acute Lung Injury, Pulmonary Edema, and Multiple System Organ Failure." In Egan's Fundamentals of Respiratory Care 10th Edition. -. St Louis: Mosby Elsevier, January 2012.

Exline, MC; Mireles-Cabodevila, E; Hite RD. "Acute Respiratory Distress Syndrome." In Egan's Fundamentals of Respiratory Care. 11th ed. Edited by Kacmarek, RM; Stoller, JK; Heuer, AJ. -. St Louis, MO, US|USA: Elsevier, January 2016.

 

Clinical Services

07/01/2006 In-Patient Medical Center Service - 40% FTE (8ICU, MICU, Ross, James, OSU East, OSU Main)
07/01/2007 Outpatient Clinic - 10% FTE (Martha Morehouse Medical Plaza)

Conferences

Exline, M, Fahy, R, Gavrilin, MA, Duncan, MD, Wewers, MD. "Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients." In Proceedings of the American Thoracic Society. (May 2006). A328-.

Exline, M, Fah,y RJ, Hall, MW, Bhatt, NY, Wewers, MD. "Plasma Caspase-1 Levels Elevated in Patients with Septic Shock." In Proceedings of the American Thoracic Society. (May 2007). A440-.

Strack, LK, Sarkar, A, Exline, M, Wewers, MD. "Whole Blood Responses to Pathogenic Versus Nonpathogenic E. coli: Bacterial Killing Efficiency and Cytokine Profiling." In Proceedings of the American Thoracic Society. (May 2008). A432-.

Exline, M, Besecker, BY, Hollyfield, JL, Gavrilin, MA, Fahy, RJ, Wewers, MD. "Inflammasome mRNA Expression in Critically Ill Patients." In Proceedings of the American Thoracic Society. (May 2008). A123-.

Besecker, BY, Exline, M, Hollyfield, JL, Josephs, E, DiSilvestro, RA, Knoell, DL. "Modulation of Zinc Homeostasis Via Zinc Transporters in Humans with Sepsis." In Proceedings of the American Thoracic Society. (May 2008). A120-.

Exline,M, Hollyfield, J, Gavrilin, M, Nana-Sinkam, S, Wewerss, M. "Cigarette Smoke Extract Suppresses Innate Immune Response in Peripheral Blood Monocytes.." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2009). /-.

Pell,Lindsay; Mount,Kari; Doepker,Bruce; Exline,Matthew. "ACHIEVING ADEQUATE AMIKACIN LEVELS IN A MEDICAL INTENSIVE CARE UNIT." In CRITICAL CARE MEDICINE. (December 2009). A405-A405.

Exline, M, Sarkar, A, Besecker,B, Hollyfield,J, Mitra,S, Wewers, M. "Inflammasome Constituents Released Via Microvesicles During Sepsis." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2010). /-.

Exline,M, Hollyfield,J, Besecker,B,Y, O'Brien,J, Ali,N, Wewers, M. "Pathogen Sensor NLRP3 Suppressed During Sepsis And Improves During Recovery." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2011). /-.

Chacey,M, Exline,M, Hollyfield,J, Wewers, M. "Serum And Alveolar LL-37 Is Elevated In Respiratory Failure Patients But Not In Septic Patients." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2011). /-.

Torrence, K, Vermillion, B, St. Clair, J, Zikri, N, Sopirala, M, Ali, N, Exline, M. "The Power of Team: Utilizing A Multi-Faceted, Interdisciplinary Approach To Reduce Central Line Associated Blood Stream Infections." In Critical Care Medicine. (February 2011). 161-.

Russo, AN, Wewers, MD, Fahy, R, Hollyfield, J, Exline, M. "Severity Of Illness, Not Pathogen Determines Suppression Of Pathogen Sensors In Sepsis." In Am J Respir Crit Care Med. (May 2012). A5761-.

Besecker, BY, Zakharova, E, Hollyfield, J, Exline, M. "Sepsis Outcomes May Improve In Patients With Improved Plasma Zinc Concentration ICU Day Five." In Am J Respir Crit Care Med. (May 2012). A5765-.

Exline, M, Hollyfield, J, Besecker, B, Ali, N,O'Brien, JM, Wewers, MD. "NOD1 And NOD2 Message Suppressed In Septic Patient Monocytes." In American Journal of Respiratory and Critical Care Medicine. (May 2012). A5764-.

Haas,E, Taylor,J, Ali,N, Exline,M. "Does a Negative Gram Stain Predict the Absence of Potentially Resistant Organisms?." In CHEST. (October 2013). /-.

Exline, M, Justiniano, SE, Hollyfield, J, Besecker, BY, Ali, N, Mitra, S, Wewers, MD, Sarkar, A.. "Sepsis Triggers Release Of Microvesicles Containing Caspase-1 In Active Form." In Am J Respir Crit Care Med. (May 2013). A2786-.

Van Berkel,Megan; Exline,Matthew; Mount,Kari; Ryder,Lindsay; Philips,Gary; Ali,Naeem; Doepker,Bruce. "Clinical hypotension with etomidate or ketamine used for intubation in a medical intensive care unit." In CRITICAL CARE MEDICINE. (December 2013). n/a-.

Mukku,Sindhu; Kynyk,Jessica; Exline,Matthew. "A Rare Case of Sarcoidosis of the Tongue in a Patient With Occupational Beryllium Exposure." In CHEST. (October 2013). A660-.

Westman, RP, McCann, E, Mieczkowski, BP, Exline, M, Patterson, E, Vermillion, B, Ali, N. "Intensivist And Resident Team Situational Awareness Improves Over Four Weeks Of An ICU Rotation." In Am J Respir Crit Care Med. (May 2013). A1599-.

McCann, E, Mieczkowski, BP, Exline, M, Patterson, E, Vermillion, B, Ali, N. "Measurement Of Team Situational Awareness Across Disciplines After Multidisciplinary ICU Rounds." In Am J Respir Crit Care Med. (May 2013). A1597-.

Justiniano, SE, Berhe, F, Exline, M, Chacey, M, Wewers, MD, Sarkar, A. "LL37 Induces Microvesicular Caspase-1 And IL-1β Release And Cell Injury." In Am J Respir Crit Care Med. (May 2013). A4195-.

 

Degrees

1996 A.A.S., University of Nevada

2000 B.A., University of Nevada

2012 B.S.Ch.E., The Ohio State University

 

Editorial Activities

2006 - present Respiration
2007 - 2009 Proceedings of the American Thoracic Society
2008 - present Recent Patents on Inflammation & Allergy Drug Discovery
2008 - present Lung
2009 - present Critical Care
2009 - present American Thoracic Society Web Case of the Month
2012 - present Journal of Clinical Oncology
 

Honors

1998 Outstanding Student. Behavorial Sciences.
1998 Outreach Clinic Award for Service. University of Nevada.
2000 Alpha Omega Alpha Medical Honor Society. AOA.
2000 Graduation Guest Speaker. Class of 2000.
2003 - present Gorilla Award. Department of Internal Medicine.
2005 - present Best Case Report in Cancer Case I. ACCP Chest 2005.
2009 - 2014 Best Doctors in America. Best Doctors, Inc..
2010 - present Faculty Teaching Award in the Critical Care Setting. Department of Internal Medicine.
2013 - present Buckeye Adult Lung Award - Excellence in Fellowship Teaching. Division of Pulmonary, Allergy, Critical Care, and Sleep.
2014 - present Exceptional Physician Peer Award. Physician Faculty Engagement Committee.
2014 - present Faculty Teaching Award in Critical Care. Ohio State University Department of Internal Medicine.
2015 - present Faculty Teaching Award in Critical Care. Department of Internal Medicine.
2015 - present Mentor of the Year, Class of 2015 students entering Internal Medicine. Department of Internal Medicine.
2015 - present College of Medicine Faculty Achievement Award. The Ohio State University College of Medicine.
2016 - present Lead.Serve.Inspire Part 3 Excellence in Education Award. The Ohio State University College of Medicine.
2016 - present Courage to Teach Society. Courage to Teach Society.
 

Journal Articles

Sarkar, A, Hall, MW, Exline, M, Hart, J, Knatz, N, Gatson, N, Wewers, MD. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1 beta and interleukin-18." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 174, no. 9. (November 2006.): 1003-1010.

Sarkar, Anasuya; Hall, Mark, W; Exline, Matthew; Hart, Judy; Knatz, Nina; Gatson, Na Tosha; Wewers, Mark D. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.." American journal of respiratory and critical care medicine. Vol. 174, no. 9. (January 2006.): 1003-10.

Exline, Matthew; Magro, Cynthia; Lin, Thomas; Sood, Namita. "Pulmonary hypertension in Hodgkin's disease.." Thorax. Vol. 62, no. 4. (January 2007.): 371-.

Benninger, C, Mastronarde, JG, Exline, M. "A 39-year-old woman with intractable asthma.." Chest. Vol. 132, no. 4. (January 2007.): 1397-1400.

Exline, M, Magro,C, Lin, T, Sood, N. "Pulmonary hypertension in Hodgkin's disease." THORAX. Vol. 62, no. 4. (April 2007.): 371-371.

Exline MC, Crouser ED. "Mitochondrial mechanisms of sepsis-induced organ failure." Frontiers of Bioscience. Vol. 13, (January 2008.): 5030-.

Fahy, RJ, Exline, M, Gavrilin, MA, Bhatt, NY, Besecker, BY, Sarkar, A, Hollyfield, JL, Duncan, MD, Nagaraja, HN, Knatz, NL, Hall, M, Wewers, MD ,. "Inflammasome mRNA expression in human monocytes during early septic shock.." American Journal of Respiratory and Critical Care Medicine. Vol. 177, no. 9. (January 2008.): 983-988.

Crouser ED*, Exline MC*, Knoell DL*, Wewers MD (*co-first authorship). "Sepsis: links between pathogen sensing and organ damage." Current Pharmaceutical Design. Vol. 14, no. 19. (January 2008.): 1840-.

Crouser, ED, Exline, M, Knoell, D, Wewers, MD. "Sepsis: Links between pathogen sensing and organ damage." CURRENT PHARMACEUTICAL DESIGN. Vol. 14, no. 19. (July 2008.): 1840-1852.

Exline, M, Crouser, ED. "Mitochondrial mechanisms of sepsis-induced organ failure." FRONTIERS IN BIOSCIENCE-LANDMARK. Vol. 13, (May 2008.): 5030-5041.

McMaken, S, Exline, M, Mehta, P, Piper, M, Wang,Y, Fischer, SN, Newland, CA, Schrader, CA, Balser, SR, Sarkar, A, Baran,CP; Marsh, CB, Cook,CH, Phillips, GS, Ali, NA. "Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity." PLOS ONE. Vol. 6, no. 5. (May 2011.): e19654-.

Besecker, BY, Exline, M, Hollyfield,JL, Phillips,G, DiSilvestro,RA, Wewers, MD; Knoell, DL. "A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission." AMERICAN JOURNAL OF CLINICAL NUTRITION. Vol. 93, no. 6. (June 2011.): 1356-1364.

Exline M, Crouser, ED. "Mitochondrial Dysfunction During Sepsis: Still More Questions Than Answers." Critical Care Medicine. Vol. 39, no. 5. (May 2011.): 1216-1217.

Sara McMaken, Matthew C. Exline, Payal Mehta, Melissa Piper, Sara N. Fischer, Christie A. Newland, Carrie A. Schrader, Shannon R. Wells, Anasuya Sarkar, Christopher P. Baran, Clay B. Marsh, Charles H. Cook, Gary S. Phillips and Naeem A. Ali. "Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity." PLoS ONE. (January 2011.): -.

Beth Besecker, Matthew Exline, Jennifer Hollyfield, Gary Phillips, Robert A. DiSilvestro, Mark D. Wewers, and Daren L. Knoell. "A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and non-infected adults early after ICU admission." The American Journal of Clinical Nutrition. (January 2011.): -.

Riscili, BP, Anderson, TB, Prescott, HC, Exline, M, Sopirala, MM, Phillips, GS, Ali, NA. "An Assessment of H1N1 Influenza-Associated Acute Respiratory Distress Syndrome Severity after Adjustment for Treatment Characteristics." PLoS ONE. Vol. 6, no. 3. (March 2011.): e18166-.

Exline, M, Sopirala, MM. "Preventing CLABSIs Through a Multidisciplinary Team Effort." Anesthesiology News. Vol. 38, no. 10. (October 2012.): 2-.

Asif, M, Exline, M. "Utilization of Hyperbaric Oxygen Therapy and Induced Hypothermia After Hydrogen Sulfide Exposure." Respiratory Care. Vol. 57, no. 2. (February 2012.): 307-.

Exline, M, Ali, NA, Zikri, N, Mangino, JE, Torrence, K, Vermillion, B, St Clair, J, Lustberg, ME, Pancholi, P, Sopirala, MM. "Beyond the bundle - journey of a tertiary care medical intensive care unit to zero central line-associated bloodstream infections.." Critical Care. Vol. 17, no. 2. (March 2013.): R41-.

Exline, M, Justiniano, S, Hollyfield, JL, Berhe, F, Besecker, BY, Das, S, Wewers, MD, Sarkar, A. "Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis In Sepsis." PLOS One. Vol. 9, no. 3. (March 2014.): e90968-.

Checkley, W, Martin, GS, Brown, SM, Chang, SY, Dabbagh, O, Fremont, RD, Girard, TD, Rice, TW, Howell, MD, Johnson, SB, O'Brien, J, Park, PK, Pastores, SM, Patil, NT, Pietropaoli, AP, Putman, M, Rotello, L, Siner, J, Sajid, S, Murphy, DJ, Sevransky, JE; United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study Investigators.. "Structure, process, and annual ICU mortality across 69 centers: United States critical illness and injury trials group critical illness outcomes study*.." Crit Care Med. Vol. 42, no. 2. (February 2014.): 344-.

Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O'Brien J, O'Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS; United States Critical Illness and Injury Trials Group-Critical Illness Outcomes Study Investigators.. "Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study." Crit Care Med. Vol. 43, no. 10. (October 2015.): 2076-84.

Thompson L, Exline M, Leung CG, Way DP, Clinchot D, Bahner DP, Khandelwal S. "A Clinical Procedures Curriculum for Undergraduate Medical Students: The Eight-Year History of a Third-Year Immersive Experience." Med Educ Online. Vol. 21, (May 2016.): 29486-.

Exline, M, Masood, S, Sopirala, MM. "A QUALITY IMPROVEMENT IMPERATIVE: ACHIEVING COMMAND OVER HOSPITAL ACQUIRED INFECTIONS IN INTENSIVE CARE UNITS." ADVANCES IN MEDICINE AND BIOLOGY. -.

 

Reference Works

January 2002 Exline, M, O'Dorisio, N, Thomas, A."Suspected Myositis Following DVT as Initial Presentation of Essential Cryofibrinogenemia" Philadelphia.
January 2005 Exline, M, Sood, N."Pulmonary Arterial Hypertension: An Unusual Presentation of Hodgkin's Disease" /. : 413S
January 2005 Exline M, Mastronarde JG."Pulmonary Renal Syndrome Seropositive for Both Antieutrophil Cytoplasmic Autoantibodies and Anti-Glomerular Basement Membrane Autoantibodies" /. : 477S
January 2008 Hollyfield, JL, Gavrilin, MA, Nana-Sinkam, P, Wewers, M, Exline, M."Smokin ICE: Cigarette Smoke Extract Suppresses Inflammation in Peripheral Blood Monocytes Production" /.
January 2008 Besecker, BY, Exline, M, Hollyfield, JL, Fong, L, DiSilvestro, RA, Knoell, DL."Modulation of Zinc Homeostasis via Zinc Transporters in Humans with Sepsis" /.
January 2008 Adkins, E, Exline, M, O'Brien, JM, Sayre, M, Ali, NA."Clinical Characteristics of In-Hospital Cardiac Arrest Patients Surviving to Hospital Discharge" /.
January 2009 Adkins, EJ, Exline, M."Sudden Onset of Wheezing at Work" /.
May 2012 Chacey, M, Exline, M."Pulmonary Toxicity from Bortezomib Successfully Treated with Steroids in a Patient with Acute Myelogenous Leukemia" /.
May 2014 R.A. Calderon, MD, M.C. Exline, MD MPH."Tailgating Gone Wrong" San Diego, CA.
May 2014 M. Tsai, MD, N.A. Ali, MD, B.Y. Besecker, MD, R.A. Calderon, MD, M.C. Exline, MD MPH."Incidence Of Refractory Hypoxemia And Effect Of Rescue Therapies On Mortality" San Diego, CA.
May 2014 L.T. Lastinger, MD, A.A. Suarez, MD, M.C. Exline, MD MPH."Cat Got Your Lungs? A Pulmonary Manifestation Of Bartonella Henselae Infection" San Diego, CA.
October 2014 Manu Kaushal M.D, Asma Azimi M.D, Mark Wewers M.D, Matthew Exline M.D.."The Great Imitator Gets Us Again" Austin, TX.
May 2015 D.M. Brown, J.A. Kynyk, N.A. Ali, J. St Clair, M. Weber, M.C. Exline."Importance of ICU Culture and Geography in Quality Initiatives" Denver, CO.
May 2015 D. Gorbett, R.A. Calderon, D.R. Closser, M.A. Ali, M. De La Cruz, M.C. Exline, J.G. Mastronarde."An Analysis of the Timeliness of Consultation and Appropriateness of Documentation in an Academic Medical Center Intensive Care Unit" Denver, CO.
May 2015 G. Lockhart, P. Mehta, M.C. Exline, J. Kynyk, N.A. Ali."MEWS Score as a Tool for Identifying Patients with Severe Sepsis and Adverse Outcomes" Denver, CO.
May 2016 Esguerra, V; Risaliti, C; Fee-Mulhearn, A; Jackson, E; Negatu, Y; Mahoney, A; Khabbaza, D; Exline, M; Kynyk, J."Mobility in the ICU: A Fellowship Quality Improvement Educational Initiative" San Francisco, CA.
May 2016 Kaushal, M; Islam, S; Exline, M."Improvement of Multi-Organ Dysfunction and Shock with Apheresis in Hypertriglyceridemia Induced Acute Pancreatitis: A Case Report" San Francisco, CA.
May 2016 Risaliti, C; Exline, M; Kynyk, J; Adkins, E; Ali, N."Modified Early Warning Score Is Associated with the Later Development and Timing of Acute Respiratory Failure in Acutely Ill Patients Admitted from an Emergency Department" San Francisco, CA.
May 2016 Negatu, Y; Exline, M; Tapyrik, S; Mathew, T; Wang, S."Factors Associated with Tuberculosis Infectiousness and Excess Alcohol Use in Franklin County, Ohio" San Francisco, CA.

Softwares

December 2012 Matthew Exline."American Thoracic Society Assembly Allergy, Immunology, Inflammation Facebook Page / Web profile"
September 2013 Matthew Exline; Jennifer McCallister; John Mastronarde; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine."Pulmonary Medical School" Apples iTunes U
October 2014 Kim Ann Zimmermann, LiveScience Contributor."Respiratory System: Facts, Function and Diseases" LiveScience
April 2016 Christian Jones, Matthew Exline."Managing Sepsis" Behind the Knife Podcast

Presentations

"The Genetics of Sepsis and the Innate Immune System." Presented at American Thoracic Society International Meeting, San Diego, CA, CA, US|USA. (January 2009)

"Diagnosis of Tuberculosis." Presented at Ohio Department of Rehabilitation and Correction, Medical Leadership Quarterly Meeting, London, OH. (January 2010)

"Beyond the Bundle – Strategies to Prevent Central Line Associated Blood Stream infections." Presented at University Health Consortium Web Conference, . (September 2014)

"Fluid Resuscitation in Septic Shock." Presented at Ohio Hospital Association Webinar, . (November 2015)

"Say Sepsis, Save Lives." Presented at Ohio Valley Medical Center, . (August 2016)

"Say Sepsis, Save Lives." Presented at West Virginia Osteopathic Medical Association Fall CME Conference, White Sulfur Springs. (November 2016)

"Could This Be Sepsis." Presented at Vizient HEN Knowledge Network Series Presentation, . (April 2016)