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Matthew Exline, MD

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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: exline.16@osu.edu


Current OSU Appointments

Associate Professor-Clinical, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep


Clinical Interest


Critical Care


Pulmonary infections including tuberculosis and nontuberculous mycobacterium and fungal infections

Creative Works



I came to Ohio State for residency after matriculating from the University of Nevada in 2000. After my residency in Internal Medicine and fellowship in Pulmonary, Critical Care, and Sleep I joined the Department of Internal Medicine as an Assistant Professor on the clinical track in 2006 as a clinician scholar.

Academic Advising

2013 - present , The Ohio State University.
2011 Sindhu Mukku, The Ohio State University. Graduated 0.
2012 Joseph Duffy, The Ohio State University. Graduated 0.
2007 - 2009 Leanne Strack, The Ohio State University. Graduated 2009.
2008 - 2010 Eric Adkins, The Ohio State University. Graduated 2010.
2009 - 2012 Michael Chacey, The Ohio State University. Graduated 2012.


2003 - present Medical License: State Medical Board of Ohio
2003 - present Internal Medicine: American Board of Internal Medicine
2005 - present Pulmonary Disease: American Board of Internal Medicine
2006 - present Critical Care: American Board of Internal Medicine
2007 - present Fundamentals of Critical Care Support: Society of Critical Care Medicine
2011 - present Sleep Medicine: American Board of Internal Medicine
2012 - present Difficult Airway Management: A Critical Care Approach: American College of Chest Physicians
2014 - present Advanced Cardiac Life Support (ACLS): The Ohio State University
2004 - 2007 Advanced Trauma Life Support: The Ohio State University

Chapters in Books

Acute respiratory distress syndrome.

Acute Lung Injury, Pulmonary Edema, and Multiple System Organ Failure


Clinical Services

07/01/2006 In-Patient Medical Center Service - 40% FTE (8ICU, MICU, Ross, James, OSU East, OSU Main)
07/01/2007 Outpatient Clinic - 10% FTE (Martha Morehouse Medical Plaza)


Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients

Plasma Caspase-1 Levels Elevated in Patients with Septic Shock

Inflammasome mRNA Expression in Critically Ill Patients

Modulation of Zinc Homeostasis Via Zinc Transporters in Humans with Sepsis

Whole Blood Responses to Pathogenic Versus Nonpathogenic E. coli: Bacterial Killing Efficiency and Cytokine Profiling


Cigarette Smoke Extract Suppresses Innate Immune Response in Peripheral Blood Monocytes.

Inflammasome Constituents Released Via Microvesicles During Sepsis

Pathogen Sensor NLRP3 Suppressed During Sepsis And Improves During Recovery

The Power of Team: Utilizing A Multi-Faceted, Interdisciplinary Approach To Reduce Central Line Associated Blood Stream Infections

Serum And Alveolar LL-37 Is Elevated In Respiratory Failure Patients But Not In Septic Patients

NOD1 And NOD2 Message Suppressed In Septic Patient Monocytes

Severity Of Illness, Not Pathogen Determines Suppression Of Pathogen Sensors In Sepsis

Sepsis Outcomes May Improve In Patients With Improved Plasma Zinc Concentration ICU Day Five

Does a Negative Gram Stain Predict the Absence of Potentially Resistant Organisms?

Clinical hypotension with etomidate or ketamine used for intubation in a medical intensive care unit

A Rare Case of Sarcoidosis of the Tongue in a Patient With Occupational Beryllium Exposure

Measurement Of Team Situational Awareness Across Disciplines After Multidisciplinary ICU Rounds

Intensivist And Resident Team Situational Awareness Improves Over Four Weeks Of An ICU Rotation

Sepsis Triggers Release Of Microvesicles Containing Caspase-1 In Active Form

Ll37 Induces Microvesicular Caspase-1 And Il-1 beta Release And Cell Injury



1996 B.S., University of Nevada

2000 M.D., University of Nevada

2012 M.Public Hlth., The Ohio State University


Editorial Activities

2006 - present Respiration
2007 - 2009 Proceedings of the American Thoracic Society
2008 - present Recent Patents on Inflammation & Allergy Drug Discovery
2008 - present Lung
2009 - present Critical Care
2009 - present American Thoracic Society Web Case of the Month
2012 - present Journal of Clinical Oncology


1998 - present Outstanding Student. Behavorial Sciences.
1998 - present Outreach Clinic Award for Service. University of Nevada.
2000 - present Alpha Omega Alpha Medical Honor Society. AOA.
2000 - present Graduation Guest Speaker. Class of 2000.
2003 - present Gorilla Award. Department of Internal Medicine.
2005 - present Best Case Report in Cancer Case I. ACCP Chest 2005.
2009 - 2014 Best Doctors in America. Best Doctors, Inc..
2010 - present Faculty Teaching Award in the Critical Care Setting. Department of Internal Medicine.
2013 - present Buckeye Adult Lung Award - Excellence in Fellowship Teaching. Division of Pulmonary, Allergy, Critical Care, and Sleep.
2014 - present Exceptional Physician Peer Award. Physician Faculty Engagement Committee.
2014 - present Faculty Teaching Award in Critical Care. Ohio State University Department of Internal Medicine.
2015 - present Faculty Teaching Award in Critical Care. Department of Internal Medicine.
2015 - present Mentor of the Year, Class of 2015 students entering Internal Medicine. Department of Internal Medicine.
2015 - present College of Medicine Faculty Achievement Award. The Ohio State University College of Medicine.
2016 - present Lead.Serve.Inspire Part 3 Excellence in Education Award. The Ohio State University College of Medicine.
2016 - present Courage to Teach Society. Courage to Teach Society.

Journal Articles



Reference Works

January 2002 Exline, M, O'Dorisio, N, Thomas, A."Suspected Myositis Following DVT as Initial Presentation of Essential Cryofibrinogenemia" .
January 2005 Exline M, Mastronarde JG."Pulmonary Renal Syndrome Seropositive for Both Antieutrophil Cytoplasmic Autoantibodies and Anti-Glomerular Basement Membrane Autoantibodies" . : 477S-478S
January 2005 Exline, M, Sood, N."Pulmonary Arterial Hypertension: An Unusual Presentation of Hodgkin's Disease" . : 413S
January 2008 Hollyfield, JL, Gavrilin, MA, Nana-Sinkam, P, Wewers, M, Exline, M."Smokin ICE: Cigarette Smoke Extract Suppresses Inflammation in Peripheral Blood Monocytes Production" .
January 2008 Adkins, E, Exline, M, O'Brien, JM, Sayre, M, Ali, NA."Clinical Characteristics of In-Hospital Cardiac Arrest Patients Surviving to Hospital Discharge" .
January 2008 Besecker, BY, Exline, M, Hollyfield, JL, Fong, L, DiSilvestro, RA, Knoell, DL."Modulation of Zinc Homeostasis via Zinc Transporters in Humans with Sepsis" .
January 2009 Adkins, EJ, Exline, M."Sudden Onset of Wheezing at Work" .
May 2012 Chacey, M, Exline, M."Pulmonary Toxicity from Bortezomib Successfully Treated with Steroids in a Patient with Acute Myelogenous Leukemia" .
December 2013 Van Berkel, M, Exline, M, Mount, K, Ryder, L, Phillips, G, Ali, N, Doepker, B."Clinical Hypotension With Etomidate or Ketamine Used for Intubation in Medical Intensive Care Unit" .
October 2013 Haas, E, Taylor, J, Ali, N, Exline, M."Does a Negative Gram Stain Predict the Absence of Potentially Resistant Organisms?" . : 386A
October 2013 Mukku, S, Kynyk, S, Exline, M."A Rare Case of Sarcoidosis of the Tongue in a Patient With Occupational Beryllium Exposure" . : 675A
January 2013 ."" .
May 2014 L.T. Lastinger, MD, A.A. Suarez, MD, M.C. Exline, MD MPH."Cat Got Your Lungs? A Pulmonary Manifestation Of Bartonella Henselae Infection" .
October 2014 Manu Kaushal M.D, Asma Azimi M.D, Mark Wewers M.D, Matthew Exline M.D.."The Great Imitator Gets Us Again" .
May 2014 M. Tsai, MD, N.A. Ali, MD, B.Y. Besecker, MD, R.A. Calderon, MD, M.C. Exline, MD MPH."Incidence Of Refractory Hypoxemia And Effect Of Rescue Therapies On Mortality" .
May 2014 R.A. Calderon, MD, M.C. Exline, MD MPH."Tailgating Gone Wrong" .
May 2015 G. Lockhart, P. Mehta, M.C. Exline, J. Kynyk, N.A. Ali."MEWS Score as a Tool for Identifying Patients with Severe Sepsis and Adverse Outcomes" .
May 2015 D.M. Brown, J.A. Kynyk, N.A. Ali, J. St Clair, M. Weber, M.C. Exline."Importance of ICU Culture and Geography in Quality Initiatives" .
May 2015 D. Gorbett, R.A. Calderon, D.R. Closser, M.A. Ali, M. De La Cruz, M.C. Exline, J.G. Mastronarde."An Analysis of the Timeliness of Consultation and Appropriateness of Documentation in an Academic Medical Center Intensive Care Unit" .
May 2016 Kaushal, M; Islam, S; Exline, M."Improvement of Multi-Organ Dysfunction and Shock with Apheresis in Hypertriglyceridemia Induced Acute Pancreatitis: A Case Report" .
May 2016 Esguerra, V; Risaliti, C; Fee-Mulhearn, A; Jackson, E; Negatu, Y; Mahoney, A; Khabbaza, D; Exline, M; Kynyk, J."Mobility in the ICU: A Fellowship Quality Improvement Educational Initiative" .
May 2016 Risaliti, C; Exline, M; Kynyk, J; Adkins, E; Ali, N."Modified Early Warning Score Is Associated with the Later Development and Timing of Acute Respiratory Failure in Acutely Ill Patients Admitted from an Emergency Department" .
May 2016 Negatu, Y; Exline, M; Tapyrik, S; Mathew, T; Wang, S."Factors Associated with Tuberculosis Infectiousness and Excess Alcohol Use in Franklin County, Ohio" .


December 2012 Matthew Exline."American Thoracic Society Assembly Allergy, Immunology, Inflammation Facebook Page / Web profile"
September 2013 Matthew Exline; Jennifer McCallister; John Mastronarde; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine."Pulmonary Medical School" Apples iTunes U
October 2014 Kim Ann Zimmermann, LiveScience Contributor."Respiratory System: Facts, Function and Diseases" LiveScience
April 2016 Christian Jones, Matthew Exline."Managing Sepsis" Behind the Knife Podcast


The Genetics of Sepsis and the Innate Immune System

Beyond the Bundle – Strategies to Prevent Central Line Associated Blood Stream infections

Fluid Resuscitation in Septic Shock

Say Sepsis, Save Lives

Say Sepsis, Save Lives

Could This Be Sepsis