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Mark D. Wewers, MD


Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-7707

Email: wewers.2@osu.edu

 

Current OSU Appointments

Faculty Emeritus, Pulmonary, Crit Care, & Sleep

Retiree-Faculty Emeritus, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep

 

Biographical

Dr. Wewers trained in pulmonary medicine under the direction of Dr. Roger C. Bone at the University of Arkansas for Medical Sciences and then completed a 5 year research experience in the Pulmonary Branch of the National Institutes of Health under the guidance of Dr. Ronald G. Crystal. He was recruited to the faculty of the Ohio State University in 1986 where he has been continously supported by extramural funds from the NIH for his work on lung innate immune function since 1989. In 1996 he was named Division Director of Pulmonary and Critical Care Medicine at Ohio State University and Deputy Director of the Davis Heart and Lung Research Institute in 1997 where he served as interim director from 2000-2002. In 2000 he was bestowed the honor of the John A. Prior Professorship. Dr. Wewers has been a frequent external reviewer for the NIH and served as a permanent member of the Lung Biology and Pathology A study section from 1996-2000. He currently serves as Associate Director of the Davis Heart and Lung Research Institute where he is active in graduate programs and directs an NIH T32 training program on the molecular mechanisms of lung inflammation.

Clinical Interest

Emphysema

Alpha 1-antitrypsin deficiency

Lung inflammation

Sepsis

Licenses

1979 - present Board Certification (Diplomate): American Board of Internal Medicine
1982 - present Board Certification (Diplomate): American Board of Internal Medicine
1986 - present Medical License: State Medical Board of Ohio
1989 - present Board Certification (Diplomate): American Board of Internal Medicine
2010 - 2012 ACLS Provider: American Heart Association
 

Chapters in Books

Flexible fiberoptic bronchoscopy.

Emphysema and Chronic Bronchitis

Diagnostic Procedures

Dyspnea and Cirrhosis

Proinflammatory Peptides

Cytokines and Macrophages

Augmentation of Liver Production

Cytokines and Macrophages

The pathogenesis of sepsis - Factors that modulate the response to gram-negative bacterial infection

Proinflammatory Cytokines

 

Conferences

New developments in the treatment of depression

 

Degrees

1972 B.A., University Of Arkansas

1976 M.D., University Of Arkansas

 

Editorial Activities

present Proceedings of the National Academy of Sciences
present New England Journal of Medicine
present Journal of Biological Chemistry
present CHEST
present Blood
present American Journal of Respiratory and Critical Care Medicine
present American Journal of Physiology
present Journal of Clinical Investigation
present Infection and Immunity
present Genes and Immunity
present Cytokine
present
present Public Library of Science One
present Journal of Immunological Methods
present Critical Care Medicine
present American Journal of Respiratory Cell and Molecular Biology
1999 - 2003 Journal of Immunology
 

Honors

1973 McGuire Scholarship Recipient.
1976 Alpha Omega Alpha.
1998 Unverferth Award for Leadership in Research. Department of Internal Medicine, College of Medicine.
2000 John A. Prior Professorship.
2003 Distinguished Mentor Award. Davis Heart and Lung Research Institute.
2005 America's Best Doctors.
2006 Collaborative Leader Award. Davis Heart and Lung Research Institute.
2007 - present America's Best Doctors. U.S. News & World Report.
2011 America's Best Doctors.
 

Journal Articles

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Reference Works

January 2002 Doseff, A. I.; Sancaktar, O.; Waggoner, A. N.; Wewers, M. D.."Caspase-3 is a phosphoprotein that associates with and is phosphorylated selectively by a PKC isoforms during monocyte lifespan" . : A658
January 2002 Parker-Barnes, J. M.; Yee, J. F.; Doseff, A. I.; Wewers, M. D.."Isolation and characterization of lkappaBzeta, a new member of the lkappabeta family; interactions with IL-1beta" . : 282
January 2002 Parker-Barnes, J. M.; Yee, J. F.; Doseff, A. I.; Guo, W.; Wewers, M. D.."MAIL gene (1KBzeta) rapidly induced by LPS in monocytes but not in alveolar macrophages" . : A536
January 2002 Elssner, A.; Duncan, M.; Wewers, M. D.."Anti-serum to interleukin-18 enhances HIV-1 production in monocyte derived macrophages" . : A298
January 2002 Kim, H-J.; Guo, W.; Hart, J.; Wewers, M. D.."Monocyte IL-1Beta converting enzyme activation: kinetics and relationship to IL-1Beta release" . : 187
January 2002 Guo, W.; Kim, H-J., Wewers, M. D.."CARDIAK interacts with caspase-1 during endotoxin activation of human monocytes" . : 84
January 2002 Fahy, R. J.; Lichtenberger, F.; Wewers, M. D.."Functionally active TGF-Beta 1 is elevated in adult respiratory distress syndrome bronchoalveolar lavage fluid" . : A756
January 2003 Tandon, R.; Wewers, M. D.."Monocyte induction of lung epithelial cell (A549) IL-8 release is dependent upon cell contact and IL-1beta" . : A644
January 2003 Bao, S. Y.; Gavrilin, M. R.; Diaz, P. T.; Wewers, M. D.; Knoell, D. L.."HIV-1 infects differentiated human lung epithelial cells from the basolateral surface and requires galactosylceramide" . : A196
January 2003 Knoell, D. L.; Yearsdley, M.; Bao, S. Y.; Diaz, P. T.; Wewers, M. D.; Nuovo, G. J.."HIV-1 infection of human lung epithelium in vitro and in vivo" . : A870
January 2003 Doseff, A. I.; Voss, O.; Wewers, M. D.."Caspase-3 is a phosphoprotein that associates with and is phosphorylated selectively by a PCK during monocytes lifespan" . : A298
January 2003 Wewers, M. D.; Guo, W.."CARDIAK/RIP2 is expressed in both monocytes and alveolar macrophages and phosphorylates ERK2 after endotoxin challenge" . : A732
January 2003 Fahy, R. J.; Elssner, A.; Wewers, M. D.."The antimicrobial peptide LL-37/hCAP-18 is elevated in early ARDS" . : A759
January 2003 Elssner, A.; Duncan, M.; Wewers, M. D.."The human cathelicidin-derived peptide LL37 induces secretion of IL-1beta via transient ATP release and activation of the P2X7 receptor" . : A759
January 2003 Bao, S. Y.; Tripp, R. P.; Gavrilin, M. A.; Diaz, P. T.; Wewers, M. D.; Knoell, D. L.."HIV-1 infection of the Human Lung Epithelium by Free Virus and Cell-to-Cell Contact" .
January 2003 Zhang, H.; Wewers, M. D.; Doseff, A. I.; Chalmers, J. J.."A Novel immunomagnetic based technology to quantify the numbers of receptors on human alveolar macrophages" . : A481
January 2004 Fahy, R. J.; Karavanov, A.; Schneider, G. P.; Wewers, M. D.."Proteomic patterns of BAL fluid in early acute respiratory distress syndrome" . : A44
January 2004 Sarkar, A.; Hall, M. W.; Wewers, M. D.."Interleukin-1 beta converting enzyme knockout state is protective in experimental murine E-coli sepsis" . : A453-A454
January 2004 Tridandapani, S.; Fang, H.; Wei, G.; Cao, X.; Pengal R. A.; Wewers, M. D.; Marsh, C. B.; Ostrowski, M. C.."Macrophage inflammatory responses to lipopolysacharide is regulated by the concerted action of lipid phosphatases and kinases" . : C34
January 2004 Steinhour, E.; Lawson, C.; Hart, J.; Varadharaj, S.; Zweier, J.; Wewers, M. D.; Parinandi, N.."Airborne agricultural dust-induced inflammatory cytokine secretion by respiratory epithelial cells: mechanism of regulation by cell signaling" . : C52
January 2004 Hall, M. W.; Gavrilin, M. A.; Wewers, M. D.."Monocyte lkappabeta alpha/NFkappabetap50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)" . : 330
January 2004 Kim, H-J.; Hart, J.; Knatz, N.; Hall, M. W.; Wewers, M. D.."Janus kinase 3 downregulates LPS induced ICE activation by autocrine IL-10" . : A34
January 2004 Knoell, D. L.; Bao, S. Y.; Kim, H-J.; Wewers, M. D.."Modulation of barrier function during death receptor mediated apoptosis in differentiated human lung epithelial cells" . : B55
January 2004 Elssner, A.; Doseff, A.; Duncan, M.; Kotur, M.; Wewers, M. D.."Interleukin-16 is constitutively present in monocytes and released during spontaneous apoptosis" . : A32
May 2004 Hall, M.; Gavrilin, M.; Duncan, M.; Knatz, N.; Wewers, M. D.."Monocyte lkappabeta alpha/NFkappabeta p50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)" .
January 2004 Wewers, M. D.; Lemeshow, S.; Lehman, D.; Drake, J.; Bees, T.; Clanton, T. L.; Diaz, P. T.."Lung CD4 counts and hemoglobin levels predict survival in asymptomatic HIV infection" . : D84
January 2005 Gavrilin, M. A.; Wewers, M. D.."Intracellular infection of monocytes by francisella activates the inflammasome complex" . : 48
January 2005 Bouakl, I. J.; Gavrilin, M. A.; Wewers, M. D.."Intracellular activation of the human monocyte inflammasome by Francisella" . : A306
January 2005 Fahy, R. J.; Yang, L.; Duncan, M. D.; Gavrilin, M. A.; Wewers, M. D.."Monocyte mRNA expression in early septic shock" . : A42
January 2005 Kim, H-J.; Gavrilin, M. A.; Hart, J. M.; Wewers, M. D.."Tyrosine 82 in CARD domain of caspase-1 negatively regulates caspase-1 activation" . : A335
January 2005 Sarkar, A.; Hart, J.; Hertlein, E.; Guttridge, D.; Wewers, M. D.>/b>."ASC is a dual regulator in caspase-1 mediated inflammation and NFkB activation." . : 65
January 2005 Seshadri, S.; Gavrilin, M. A.; Hart, J.; Duncan, M. D.; Wewers, M. D.."Pyrin expression is suppressed with monocyte to macrophage differentiation" . : A1445

Presentations

Alpha 1-antitrypsin deficiency - 15 years later

Pulmonary vascular disorders and sleep apnea

Re-establishment of the Anti-Elastase Screen of the Lower Respiratory Tract

Interleukin 1 beta and Sarcoidosis

Pathogenesis of Emphysema: Assessment of Basic Concepts Through Clinical Investigations

Proteases and Their Effect on the Fragile Lung

Interleukin 1 beta and the lung

Recent Advances in the Treatment of Alpha-1-antitrypsin Deficiency and Future Advances on the Horizon

Alpha 1-antitrypsin deficiency: diagnosis and treatment

Alveolar Macrophage IL-1 Regulation

Role of Alpha-1-antitrypsin in Cystic Fibrosis and Adult Respiratory Distress Syndrome

ProIL-1ß Detection by ELISA

New Concepts in IL-1ß Regulation: A receptor antagonist, an ICE inhibitor and a decoy receptor

Pulmonary Vasculitis Update

Clinical Implications of alpha-1-antitrypsin Gene Therapy

Cytokines in Lung Inflammation

Postgraduate Course: Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators, Cytokines in Airway Inflammation, Lung Injury, Lung Defense

Featured Speaker, Advances in Macrophage Biology, Macrophages and IL-1ß: Braking the ICE

Role of Antibody in Transplant Vascular Sclerosis

Caspases: inflammatory and suicidal, State of the Art Lecture

Cytokines in Lung Inflammation Postgraduate Course 11: Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators

Caspases: executioners of apoptosis, Symposium Speaker

Macrophages, role of smoking and emphysema

Role of epithelium in regulating alveolar macrophage HIV infection

ICE: on the crossroads of apoptosis and inflammation

Minisymposium on HIV Infection and the Lung, HIV Interactions with Lung Inflammatory and Parenchymal Cells

Macrophages: Link Between Inflammation and Cell Death

Cytokines in Lung Injury, Repair and Inflammation

CD4 lung lymphocytes predict survival in Asymptomatic HIV Infection

The inflammasome in the host defense response

Alpha(1)-Antitrypsin Deficiency

MAIL Regulates Human Monocyte IL-6 Production

 

Professional Activities

1992 - present Specialized Center of Research Interstitial Lung Disease. NIH.
1994 - present Canadian Cystic Fibrosis Foundation.
1994 - 1995 Veteran's Administration Merit Review Board.
1994 - 1996 American Lung Association, National Grant Review Board.