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Joshua A. Englert, MD


Staff photo

473 W 12th Ave
Columbus, OH 43210

Email: englert.24@osu.edu

 

Current OSU Appointments

Assistant Professor, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep

 

Noteworthy Graduate Narrative

Englert JA and Peterson BR. Inhibition of estrogen receptor mediated transcription through farneyslation and palmitoylation. Senior Honors Thesis, 2000. 40pp.

Licenses

2007 - present Massachusetts Medical License: Massachusetts Medical Board
2008 - present American Board of Internal Medicine-Board Certified: American Board of Internal Medicine
2012 - present American Board of Internal Medicine-Board Certified: American Board of Internal Medicine
2013 - present American Board of Internal Medicine-Board Certified: American Board of Internal Medicine
 

Degrees

2000 B.S., Pennsylvania State University, The

2005 M.D., University of Pittsburgh Medical School

 

Editorial Activities

2016 European Journal of Pharmacology
2016 American Journal of Respiratory and Molecular Biology
2016 Transplant Infectious Disease
 

Honors

1998 - present Alpha Epsilon Delta. Premedical Honor Society.
1999 - present Ruth E. Duffy Scholarship. Schreyer Honors College.
1999 - present Research Experience for Undergraduates (REU) Fellow. National Science Foundation.
2001 - 2003 Robert and Gertrude Harris Foundation Scholarship. Robert and Gertrude Harris Foundation.
2004 - present Alpha Omega Alpha. University of Pittsburgh School of Medicine.
2004 - present Academy of Achievement Summit. American Academy of Achievement.
2005 - present Brinton Prize. University of Pittsburgh.
2007 - present Nominee, Best Resident Teacher Award. Harvard Medical School Class of 2007.
2014 - present Young Physician Scientist Award. American Society for Clinical Investigation.
2014 - present Chair's Research Award. Department of Medicine.
 

Journal Articles

Yang,R,K; Harada,T; Li,J,Y; Uchiyama,T; Han,Y,S; Englert,J,A; Fink,M,P. "Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism." INTENSIVE CARE MEDICINE. Vol. 31, no. 5. (May 2005.): 709-717.

Englert,Joshua,A; Fink,Mitchell,P. "The multiple organ dysfunction syndrome and late-phase mortality in sepsis.." Current infectious disease reports. Vol. 7, no. 5. (September 2005.): 335-341.

Han,Y,S; Englert,J,A; Delude,R,L; Fink,M,P. "Ethacrynic acid inhibits multiple steps in the NF-kappa B signaling pathway." SHOCK. Vol. 23, no. 1. (January 2005.): 45-53.

Han,Y,S; Englert,J,A; Yang,R,K; Delude,R,L; Fink,M,P. "Ethyl pyruvate inhibits nuclear factor-kappa B-dependent signaling by directly targeting p65." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. Vol. 312, no. 3. (March 2005.): 1097-1105.

Sappington,P,L; Cruz,R,J; Harada,T; Yang,R,K; Han,Y,S; Englert,J,A; Ajami,A,A; Killeen,M,E; Delude,R,L; Fink,M,P. "The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro." BIOCHEMICAL PHARMACOLOGY. Vol. 70, no. 11. (November 2005.): 1579-1592.

Yang,Runkuan; Harada,Tomoyuki; Mollen,Kevin,P; Prince,Jose,M; Levy,Ryan,M; Englert,Joshua,A; Gallowitsch-Puerta,Margot; Yang,LiHong; Yang,Huan; Tracey,Kevin,J; Harbrecht,Brian,G; Billiar,Timothy,R; Fink,Mitchell,P. "Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock." MOLECULAR MEDICINE. Vol. 12, no. 4-6. (April 2006.): 105-114.

Killeen,M,E; Englert,J,A; Stolz,D,B; Song,M,C; Han,Y,S; Delude,R,L; Kellum,J,A; Fink,M,P. "The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. Vol. 316, no. 3. (March 2006.): 1070-1079.

Englert JA and Baron RM. "Sepsis syndrome.." The Brigham Intensive Review of Internal Medicine.. Vol. 2, (January 2008.): 308-385.

Englert JA and Baron RM. "Sepsis syndrome.." The Brigham Intensive Review of Internal Medicine.. Vol. 1, (January 2008.): 380-385.

Nakahira,Kiichi; Haspel,Jeffrey,Adam; Rathinam,Vijay,AK; Lee,Seon-Jin; Dolinay,Tamas; Lam,Hilaire,C; Englert,Joshua,A; Rabinovitch,Marlene; Cernadas,Manuela; Kim,Hong,Pyo; Fitzgerald,Katherine,A; Ryter,Stefan,W; Choi,Augustine,MK. "Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome." NATURE IMMUNOLOGY. Vol. 12, no. 3. (March 2011.): 222-U57.

Haspel,Jeffrey; Shaik,Rahamthulla,S; Ifedigbo,Emeka; Nakahira,Kiichi; Dolinay,Tamas; Englert,Joshua,A; Choi,Augustine,MK. "Characterization of macroautophagic flux in vivo using a leupeptin-based assay." AUTOPHAGY. Vol. 7, no. 6. (June 2011.): 629-642.

Fredenburgh,Laura,E; Velandia,Margarita,MSuarez; Ma,Jun; Olszak,Torsten; Cernadas,Manuela; Englert,Joshua,A; Chung,Su,Wol; Liu,Xiaoli; Begay,Cynthia; Padera,Robert,F; Blumberg,Richard,S; Walsh,Stephen,R; Baron,Rebecca,M; Perrella,Mark,A. "Cyclooxygenase-2 Deficiency Leads to Intestinal Barrier Dysfunction and Increased Mortality during Polymicrobial Sepsis." JOURNAL OF IMMUNOLOGY. Vol. 187, no. 10. (November 2011.): 5255-5267.

Dolinay,Tamas; Kim,Young,Sam; Howrylak,Judie; Hunninghake,Gary,M; An,Chang,Hyeok; Fredenburgh,Laura; Massaro,Anthony,F; Rogers,Angela; Gazourian,Lee; Nakahira,Kiichi; Haspel,Jeffrey,A; Landazury,Roberto; Eppanapally,Sabitha; Christie,Jason,D; Meyer,Nuala,J; Ware,Lorraine,B; Christiani,David,C; Ryter,Stefan,W; Baron,Rebecca,M; Choi,Augustine,MK. "Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 185, no. 11. (June 2012.): 1225-1234.

Lai,Peggy,S; Fresco,Jennifer,M; Pinilla,Miguel,A; Macias,Alvaro,A; Brown,Ronald,D; Englert,Joshua,A; Hofmann,Oliver; Lederer,James,A; Hide,Winston; Christiani,David,C; Cernadas,Manuela; Baron,Rebecca,M. "Chronic Endotoxin Exposure Produces Airflow Obstruction and Lung Dendritic Cell Expansion." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 47, no. 2. (August 2012.): 209-217.

Li,Yongsheng; Dalli,Jesmond; Chiang,Nan; Baron,Rebecca,M; Quintana,Carolina; Serhan,Charles,N. "Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators." IMMUNITY. Vol. 39, no. 5. (November 2013.): 885-898.

Langley,Raymond,Jg; Tsalik,Ephraim,L; van Velkinburgh,Jennifer,C; Glickman,Seth,W; Rice,Brandon,J; Wang,Chunping; Chen,Bo; Carin,Lawrence; Suarez,Arturo; Mohney,Robert,P; Freeman,Debra,H; Wang,Mu; You,Jinsam; Wulff,Jacob; Thompson,J,Will; Moseley,M,Arthur; Reisinger,Stephanie; Edmonds,Brian,T; Grinnell,Brian; Nelson,David,R; Dinwiddie,Darrell,L; Miller,Neil,A; Saunders,Carol,J; Soden,Sarah,S; Rogers,Angela,J; Gazourian,Lee; Fredenburgh,Laura,E; Massaro,Anthony,F; Baron,Rebecca,M; Choi,Augustine,MK; Corey,G,Ralph; Ginsburg,Geoffrey,S; Cairns,Charles,B; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Christopher,W; Kingsmore,Stephen,F. "An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis." SCIENCE TRANSLATIONAL MEDICINE. Vol. 5, no. 195. (July 2013.): 195ra95-.

Nakahira,Kiichi; Kyung,Sun-Young; Rogers,Angela,J; Gazourian,Lee; Youn,Sojung; Massaro,Anthony,F; Quintana,Carolina; Osorio,Juan,C; Wang,Zhaoxi; Zhao,Yang; Lawler,Laurie,A; Christie,Jason,D; Meyer,Nuala,J; Mc Causland,Finnian,R; Waikar,Sushrut,S; Waxman,Aaron,B; Chung,Raymond,T; Bueno,Raphael; Rosas,Ivan,O; Fredenburgh,Laura,E; Baron,Rebecca,M; Christiani,David,C; Hunninghake,Gary,M; Choi,Augustine,MK. "Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation." PLOS MEDICINE. Vol. 10, no. 12. (December 2013.): e1001577-.

Rogers,Angela,J; McGeachie,Michael; Baron,Rebecca,M; Gazourian,Lee; Haspel,Jeffrey,A; Nakahira,Kiichi; Fredenburgh,Laura,E; Hunninghake,Gary,M; Raby,Benjamin,A; Matthay,Michael,A; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Christopher,W; Kingsmore,Stephen; Langley,Ray,J; Choi,Augustine,MK. "Metabolomic Derangements Are Associated with Mortality in Critically Ill Adult Patients." PLOS ONE. Vol. 9, no. 1. (January 2014.): e87538-.

Langley,Raymond,J; Tipper,Jennifer,L; Bruse,Shannon; Baron,Rebecca,M; Tsalik,Ephraim,L; Huntley,James; Rogers,Angela,J; Jaramillo,Richard,J; O'Donnell,Denise; Mega,William,M; Keaton,Mignon; Kensicki,Elizabeth; Gazourian,Lee; Fredenburgh,Laura,E; Massaro,Anthony,F; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Chris,W; Kingsmore,Stephen,F; Soporil,Mohan,L; Perrella,Mark,A; Choi,Augustine,MK; Harrod,Kevin,S. "Integrative "Omic" Analysis of Experimental Bacteremia Identifies a Metabolic Signature That Distinguishes Human Sepsis from Systemic Inflammatory Response Syndromes." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 190, no. 4. (August 2014.): 445-455.

Haspel,Jeffrey,A; Chettimada,Sukrutha; Shaik,Rahamthulla,S; Chu,Jen-Hwa; Raby,Benjamin,A; Cernadas,Manuela; Carey,Vincent; Process,Vanessa; Hunninghake,G,Matthew; Ifedigbo,Emeka; Lederer,James,A; Englert,Joshua; Pelton,Ashley; Coronata,Anna; Fredenburgh,Laura,E; Choi,Augustine,MK. "Circadian rhythm reprogramming during lung inflammation." NATURE COMMUNICATIONS. Vol. 5, (September 2014.): 4753-.

Englert,Joshua,A; Macias,Alvaro,A; Amador-Munoz,Diana; Vera,Miguel,Pinilla; Isabelle,Colleen; Guan,Jiazhen; Magaoay,Brady; Velandia,Margarita,Suarez; Coronata,Anna; Lee,Awapuhi; Fredenburgh,Laura,E; Culley,Deborah,J; Crosby,Gregory; Baron,Rebecca,M. "Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity." ANESTHESIOLOGY. Vol. 123, no. 2. (August 2015.): 377-388.

 

Reference Works

January 2012 Englert JA, Pinilla-Vera M, Hindi KM, Henske EP, Choi AMK, Baron RM.."The role of mTORC1 activation in ventilator induced lung injury." San Francisco.
January 2013 Englert JA, Macias AA, Pinilla-Vera MA, Guan J, Suarez-Velandia MM, Fredenburgh LF, Culley DJ, Crosby GJ, Baron RM.."Inhaled isoflurane ameliorates acute lung injury by preserving epithelial tight junction integrity." Philadelphia.
January 2014 Englert JA, Pinilla-Vera MA, Castano A, Perrella MA, Baron, RM.."Survival after CLP in surfactant protein D deficient mice is dependent upon gut microbial flora." San Diego.
January 2014 Englert JA, Boudreault F, Pinilla-Vera MA, Kho AT, Quintana C, Amador-Munoz D, Tschumperlin DT, Baron RM.."Zinc deficiency primes the lung for ventilator induced lung injury." Chicago.

Softwares

January 2003 Englert, JA."Ask a Scientist"

Presentations

"Role of NOS-2 in a mouse model of sepsis induced ARDS." Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital, . (January 2009)

"mTORC1 activation and impaired autophagy in ventilator induced lung injury." Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital, . (January 2010)

"Role of mTORC1 activation in the pathogenesis of stretch induced lung injury." Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital, . (January 2011)

"Role of surfactant protein D in polymicrobial sepsis." Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital, . (January 2013)

"Zinc deficiency primes the lung for ventilator induced lung injury." Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital, . (January 2014)

"Role of mechanical mTORC1 activation in ventilator induced lung injury." Presented at Invited Research Seminar, Columbus. (January 2015)

 

Professional Activities

present Homeless Outreach Education Program.
2014 - present Mentoring with Honors Program. Schreyer Honors College, The Pennsylvania State University.
2015 - present Expert for Discussions. New England Journal of Medicine Group Open Forum.
2012 - 2013 Formal Supervision.
2013 Formal Supervision.
2014 Formal Supervision.
2012 - 2015 Supervision of Summer Research Fellow. Pulmonary and Critical Care Medicine research laboratory.
2014 - 2015 Review Cases Gallup Indian Health Services. ICU Case Conference.