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Elliott D. Crouser, MD


Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: crouser.1@osu.edu

 

Current OSU Appointments

Professor, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep

 

Biographical

Over the past 20 years I have established myself as an internationally recognized expert in two distinct, but scientifically related fields of investigation. My initial interest in research was directed at sepsis, the #1 killer of patients in the medical intensive care units. My contributions to understanding why multiple organs fail, the usual cause of death during sepsis, which were initially published as early as 1995 continue to be recognized as cutting edge and have been confirmed by numerous subsequent studies conducted by other laboratories. I continue to engage in research relating to sepsis, both basic and translational, through extramural grant support. My funding history includes support from The American Heart Association, American Lung Association, and NIH. My sepsis research has led to my involvement in the planning of research programs and international conferences sponsored by the American Thoracic Society and the Society of Critical Care Medicine.

In addition to sepsis, my outpatient clinic has become specialized to care for patients with sarcoidosis. Like sepsis, sarcoidosis is a systemic inflammatory disorder that causes damage and dysfunction of multiple organs. My research in sarcoidosis has been amply funded through extramural agencies (American Thoracic Society, Foundation for Sarcoidosis Research, NIH), and has led to a number of high impact publications. Under my direction, the sarcoidosis program at The Ohio State University is gaining national and international recognition. Based upon my contributions to the field, I have been appointed by the National Heart, Lung and Blood Institute to co-chair a workshop relating to the future of sarcoidosis research.

I graduated from Oberlin College with a major in Geology, after which I worked for a year in a research laboratory at Case Western Reserve’s Rainbow Baby’s and Children’s Hospital. I became committed at that time to a career in medicine and took additional courses at Case Western Reserve University to prepare for medical school. I subsequently enrolled in the Medical College of Ohio in Toledo and received A.O.A. recognition (top ten in my class of over 180 students) during my senior year. I completed an internship and residency in internal medicine and a fellowship in pulmonary and critical care medicine at Ohio State University’s College of Medicine. During my fellowship I received advanced research training in the laboratory of Dr. Paul Dorinsky in the Division of Pulmonary and Critical Care Medicine. I have been a faculty member of the Division and of the Department of Internal Medicine since 1995. My research career was launched while investigating the pathogenesis of organ failures in the context of sepsis but significantly was impacted by Dr. Dorinsky’s departure from academia in 1997, at which time I prematurely assumed a lead role in that laboratory.

Based upon my independent research in the fields of sepsis and mitochondrial biology, as well as my service to the institution, I was promoted to Associate Professor of Internal Medicine on the tenure track in 2006. Since then, I have continued to engage in research of sepsis and related mitochondrial disorders, and I am expanding this area of basic research to include novel experimental clinical trials. I have also developed a new clinical and translational research program relating to systemic sarcoidosis. Under my direction the clinical and research initiatives of the sarcoidosis program at OSU are gaining national and international recognition. The sarcoidosis program is becoming multidisciplinary, and I am collaborating with the Department of Internal Medicine and the Davis Heart and Lung Research Institute to plan the creation of a “Sarcoidosis Center of Excellence”, which will further distinguish the sarcoidosis program through the development of related clinical and translational research missions.

Academic Advising

2011 - present Obada Shaama, The Ohio State University. Mechanisms of Inflammasome Activation Duirng Acute Cell Stress
2013 Douglas Closser,, The Ohio State University. Graduated 0. Computerized CT Image Analysis in Sarcoidosis
2014 Manu Kaushal, Ohio State University College of Medicine. Graduated 0. Risk stratification of cardiac sarcoidosis with MRI
1999 - 2000 Dora Blaho, The Ohio State University. Graduated 2005. Mitochondrial Failure During Endotoxemia
1999 - 2002 Anuj Goyal,, The Ohio State University. Graduated 2002. Monocyte Activation By Akt
2001 - 2003 Juan Morales,, The Ohio State University. Graduated 2003. Proteomic Analysis of Liver Mitochondria During Sepsis
2003 Vandana Potaraju, The Ohio State University. Graduated 2005. Mechanism of Cytochrome c Release During the Mitochondrial Permeability Transition
2002 - 2005 Mandar Joshi, The Ohio State University. Graduated 2005. T32 Project- Mitochondrial FailureDuring Endotoxemia
2003 - 2005 Daniel Iltchev,, The Ohio State University. Graduated 2005. Intracellular Signaling Mechanisms Controlling Monocyte Survival
2003 - 2005 Imad Bouakl,, The Ohio State University. Graduated 2005. Mechanisms of Monocyte Activation by Francisella tularensis
2002 - 2007 Udayan Bhatt,, The Ohio State University. Graduated 2007. Adenoviral Gene Therapy for Diabetic Kidney Disease
2006 - 2009 Meghan McCullers,, The Ohio State University. Graduated 2009. T32 Project- Lung Epithelial Cell Migration in Response to Mitochondrial Antigens
2009 Yu Pei, The Ohio State University. Innate Immune Responses to Mitochondiral Antigens
2008 - 2011 Britta Liese, The Ohio State University. Graduated 2011. Mechanism of Laminitis in Horses
2009 - 2011 Michael Thacker, The Ohio State University. Graduated 2009. In Silico Modeling of T Cell Responses in Sarcoidosis
2008 - 2012 Selnur Erdal, The Ohio State University. Graduated 2012. Development of a High Throughput Integrated Pulmonary Image/Data Interface
2010 - 2012 Michael Chacey,, The Ohio State University. Graduated 2012. The Role of LL37 During Acute Lung Injury
2012 - 2013 Steven Friedenberg, The Ohio State University. Graduated 2013. Mitochondrial Danger Signals in Canine Critical Illness
2012 - 2013 Carleen Risaliti,, The Ohio State University. Computer CT Image Analysis in Idiopathic Pulmonary Fibrosis
2012 - 2014 Yasmin Siddiqui,, The Ohio State University. Graduated 0. Cardiac MRI to Characterzie Acute Myocardial Injury During Severe Sepsis
2012 - 2014 Jennifer Muszynski,, The Ohio State University. Graduated 0. Transfusion-Related Immune Suppression During Critical Illness
2012 - 2015 Henry Chang, The Ohio State University. Graduated 2015. Cardiac MRI to Detect at Risk Myocardium During Non-ST Segment MI
 

Licenses

1992 - present Board Certification: American Board of Internal Medicine
1994 - present Board Certification: American Board of Internal Medicine
1995 - present Board Certification: American Board of Internal Medicine
1995 - present Medical License: State Medical Board of Ohio
2004 - present Board Re-Certification: American Board of Internal Medicine
2004 - present Board Re-Certification: American Board of Internal Medicine
2014 - present Board Re-Certification: American Board of Internal Medicine
 

Chapters in Books

Pulmonary oedema

Clinical assessment of tissue oxygenation

Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome

Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome

Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome

Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome

Pathogenesis of Organ Failure During Sepsis

 

Clinical Services

01/01/1995 MICU; 4 Doan ICU; OSU East; James,Ross, and UH Consult; Pulmonary Ward; Select; and Risk IP Services (Various Locations Affiliated with The Ohio State University Medical Center)
01/01/1995 Pulmonary Sarcoidosis Outpatient Clinic (Martha Morehouse Medical Pavilion)

Conferences

ACID-INDUCED LUNG INJURY RESULTS IN ENDOTHELIAL INJURY WITHOUT ALTERING THE VO2-DO1 RELATIONSHIP IN THE ILEUM

Endotoxin-induced mitochondrial injury in the ileum is attenuated by a free radical spin trap

Sepsis-induced ileal mitochondrial injury correlates with altered oxygen metabolism.

Hepatic mitochondrial oxygen metabolism is impaired during endotoxemia.

Free radical scavenging prevents the development of endotoxin-induced alterations in ileal microvascular permeability and VO2-DO2 relationships.

Endotoxin-induced VO2-DO2 alterations and mitochondrial injury occur in the ileum without a decrease in ileal oxyhemoglobin levels.

Despite maintenance of mucosal blood flow, endotoxin-induced mitochondrial injury and altered VO2-DO2 relationships occur in the ileum.

Nitric oxide dysregulation correlates with mitochondrial injury in the ileum following endotoxin.

Ca2+ independent phospholipase A(2) (PLA(2)) of possible significance in initiating mitochondrial apoptosis

Analytical quantitation of cytochrome c release from rat liver mitochondria

Cardiac dysfunction is associated with myocyte mitochondrial injury in a resuscitated model of acute bacterial sepsis

Fractional cytochrome c release from isolated rat mitochondria quantified with reverse-phase HPLC.

Cardiac dysfunction is associated with myocyte mitochondrial injury in a resuscitated model of acute bacterial sepsis

Mituchondrial iPLA(2) activity promotes release of cytochrome c

Left ventricular dysfunction in a feline model of acute sepsis: Relation to NOS2 induction and mitochondrial ultrastructural injury

Cardiac dysfunction, mitochondrial ultrastructural injury, and NOS2 induction in a feline model of acute sepsis

Attenuation of left ventricular dysfunction in a feline model of acute sepsis by cyclosporin A: Relation to TLR4 induction, NOS2 induction and protein nitration

Impaired mitochondrial function and structure in the liver during subacute sepsis

Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome.

Damage and depletion of mitochondria in the liver during CLP sepsis

Cyclosporin A prevents sepsis related cardiac dysfunction and mitochondrial injury in a feline model of acute sepsis

Cyclosporin A attenuates left ventricular dysfunction in a feline model of acute sepsis: relation to TLR4 induction, NOS2 induction and protein nitration

Prevention of sepsis related cardiac dysfunction and mitochondrial injury by Cyclosporin A in a feline model of acute sepsis

The susceptibility to mitochondriial damage differs in vital organs in the context of sepsis.

Induction of inflammation by mitochondrial proteins.

Flavopiridol decreases Mcl-1 and initiates early mitochondrial damage in chronic lymphocytic leukemia (CLL) cells.

MITOCHONDRIAL TRANSCRIPTION FACTOR A (TFAM) PROMOTES DENDRITIC CELL ACTIVATION VIA RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS (RAGE).

Infliximab Reverses Peripheral CD4+T Cell Depletion in Lymphopenic Sarcoidosis Patients

PI-3K Is Essential for Plasmacytoid Dendritic Cell Type I IFN Responses to Mitochondrial Transcription Factor A (TFAM) and CpG DNA

MITOCHONDRIAL DANGER SIGNALS PROMOTE LUNG EPITHELIAL CELL IL-8 RELEASE VIA FORMYL PEPTIDE RECEPTORS

Mitochondrial Antigens are Selectively Recognized by TLR-2 in the Context of Cell Necrosis

MicroRNA Targets The Neopterin Pathway In Pulmonary Sarcoidosis

Proceedings of the 2014 AASOG conference.

 

Degrees

1983 B.A., Oberlin College

1989 M.D., Medical College of Ohio

 

Editorial Activities

present The Online Journal of Critical Care Medicine
present Biochimica et Biophysica Acta
2004 - 2009 Annals of Surgery (ISI impact factor 6.4)
2004 - 2009 Free Radical Biology and Medicine (ISI impact factor 6.0)
2005 • CHEST (ISI impact factor 5.8; recognized by Editor in Chief as among top 5% of reviewers in 2012)
2005 - 2010 Mitochondrion (ISI impact factor 4.0)
2006 - present Critical Care Medicine
2007 - present Proteomics (ISI impact factor 4.1)
2007 - present Respiratory Medicine (ISI impact factor 2.0)
2007 - present Intensive Care Medicine (ISI impact factor 5.4)
2007 - present Journal of Biological Chemistry (ISI impact factor 4.6)
2007 - present Antioxidants and Redox Signaling (ISI impact factor 7.2)
2007 - present American Journal of Physiology (ISI impact factor 4.2)
2007 - present American Journal of Pulmonary and Critical Care Medicine (ISI impact factor 11.0)
2007 - present Toxicology (ISI impact factor 4.0)
2007 - present BMC Cancer (ISI impact factor 3.3)
2007 - present Lancet (England) (ISI impact factor 39.1)
2007 - present Cell & Tissue Research (ISI impact factor 3.7)
2007 - present Letters in Drug Design and Discovery
2007 Regulatory Toxicology and Pharmacology
2007 Frontiers in Biosciences
2007 “F1000 Medicine” (online journal review)
2007 - 2011 Laboratory Investigation (ISI impact factor 4.0)
2008 - present Critical Care Medicine (ISI Impact Factor 6.4) Recognized as a "Top 10" Reviewer 2008-2013
2008 Shock (ISI impact factor 2.6)
2009 - present International Journal of Interferon, Cytokine, and Mediator Research
2009 American Journal of Physiology-Lung Cellular and Molecular Physiology (ISI impact factor 4.2)
2010 Proteomics (ISI impact factor 4.1)
2011 Molecular Medicine(ISI impact factor 4.5)
2012 Respiratory Medicine (ISI impact factor 2.6)
2014 - present PLOS One
2014 Mucosal Immunology (A Nature Publication; ISI Impact factor 7.0)
2015 European Respiratory Journal
2015 • Circulation: Cardiovascular Imaging (ISI impact factor 5.9)
 

Honors

1988 - 1989 Alpha Omega Alpha. The Medical College of Ohio at Toledo.
1994 - 1995 James V. Warren Award. Department of Medicine, The Ohio State University Department of Internal Medicine.
1999 - 2000 Parker B. Francis Fellow of Pulmonary Research. Harvard School of Public Medicine.
2000 - 2005 Mentored Clinical Scientist Award. National Institutes of Health.
2001 - 2004 Career Investigator Award. American Lung Association.
2005 America's Best Doctors. U.S. News & World Report.
2006 America's Best Doctors. U.S. News & World Report.
2007 America's Best Doctors. U.S. News & World Report.
2008 America's Best Doctors. U.S. News & World Report.
2008 - 2009 Reseracher of the Year. Foundation of Sarcoidsos Research.
2009 Immunology Research Award (top immunology presentation). Society of Critical Care Medicine.
2009 America's Best Doctors. U.S. News & World Report.
2010 America's Best Doctors. U.S. News & World Report.
2011 America's Best Doctors. U.S. News & World Report.
2012 America's Best Doctors. U.S. News & World Report.
2013 Annual Scientific Award (overall top 10 research presentation). Society of Critical Care Medicine.
2013 America's Best Doctors. U.S. News & World Report.
2014 America's Best Doctors. U.S. News & World Report.
2015 - present Best Doctors. Best Doctors.
 

Journal Articles

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Reference Works

January 1994 Crouser, E. D.; Julian, M. W.; Overdahl, M. C.; Dorinsky, P. M.."Acid lung injury results in ileal endothelial injury, but not an abnormal VO2-DO2 relationship in the ileum" . : A19
January 1994 Crouser, E. D.; Julian, M. W.; Overdahl, M. C.; Dorinsky, P. M.."Endotoxin-induced alterations in ileal VO2-DO2 relationships are dose-dependent: the role of endothelial injury" . : A652
January 1994 Crouser, E.D.; , Julian, M.W.; Overdahl, M. C.; Dorinsky, P.M.."Acid-induced lung injury results in endothelial injury without altering the VO2-DO2 relationship in the ileum" . : 372A
January 1995 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Ileal VO2-DO2 alterations are not a direct effect of endotoxin and do not correlate with endothelial injury" . : A338
January 1995 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."High dose endotoxin (LPS), but not ischemia-reperfusion (I/R) injury, causes systemic organ VO2-DO2 alterations" . : A323
January 1996 Crouser, E. D..; Julian, M. W.; Dorinsky, P. M.."Ileal VO2-DO2 relationship alterations after endotoxin (LPS) correlate with the extent/severity of mitochondrial injury" . : A466
January 1996 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Diltiazem attenuates endotoxin (LPS)-induced VO2-DO2 alterations and vascular injury in the ileum" . : A465
January 1997 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Energy charge in the ileum is preserved in endotoxin (LPS)-treated animals with normal VO2-DO2 relationships" . : A403
January 1997 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Protein kinase C inhibition attenuates endotoxin (LPS)-induced ileal VO2-DO2 alterations and inflammatory injury" . : A400
January 1997 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Endotoxin (LPS) does not acutely cause mitochondrial ultrastructural damage or VO2-DO2 alterations in the ileum" . : A400
January 1998 Crouser, E. D.; Bauer, J. A.; Weinstein D. M; Blaho, D. V; Julian, M. W."Endotoxin-induced mitochondrial injury in the ileum is attenuated by a free radical spin trap" . : S83
January 1998 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Energy charge in the ileum is reduced only in endotoxin (LPS)-treated animals with abnormal VO2-DO2 relationships" . : A103
January 1998 Crouser, E. D.; Julian, M. W.."Sepsis-induced ileal mitochondrial injury correlates with altered oxygen metabolism" . : 256A
January 1998 Swaan, P. W.; Julian, M. W.; Crouser, E. D.."Barrier function of non-ischemic feline ileum after endotoxin (LPS)-induced sepsis" . : S-7
January 1998 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.; Bauer, J. A.."Endotoxin (LPS)-induced mitochondrial injury in the ileum correlates with nitric oxide (NO) dysregulation" . : A104
January 1998 Fahy, R. J.; Julian, M. W.; Wewers, M. D.; Crouser, E. D.."Endotoxin (LPS)-induced ileal cell injury results from necrosis and not apoptosis" . : A103
January 1999 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Despite maintenance of mucosal blood flow, endotoxin-induced mitochondrial injury and altered VO2-DO2 relationships occur in the ileum" . : A610
January 1999 Julian, M. W.; Blaho, D. V.; Weinstein, D. M; Bauer, J. A.; Crouser, E. D.."Free radical scavenging prevents the development of endotoxin-induced alterations in ileal microvascular permeability and VO2-DO2 relationships" . : A610
January 1999 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Endotoxin-induced VO2-DO2 alterations and mitochondrial injury occur in the ileum without a decrease in ileal oxyhemoglobin levels" . : A611
January 1999 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Hepatic mitochondrial oxygen metabolism is impaired during endotoxemia" . : S104
January 1999 Crouser, E. D.; Julian, M. W.; Weinstein, D. M.; Bauer, J. A.; (SPON: Clanton, T. L.)."Nitric oxide dysregulation correlates with mitochondrial injury in the ileum following endotoxin" . : A184
January 2000 Joshi, M. S.; Julian, M. W.; Crouser, E. D,; Bauer, J. A.."Cyclosporin A prevents left ventricular dysfunction in a feline model of acute sepsis: Relation to NOS2 induction, protein nitration and mitochondrial injury" . : A637
January 2000 Crouser, E. D.; Julian, M. W.; Pfeiffer, D. R.."Induction of the permeability transition contributes to mitochondrial injury and altered respiration during endotoxemia" .
January 2000 Goyal, A.; Graham, M. M.; Crouser, E. D.; Marsh, C. B.."Inflammatory cytokines induce monocyte survival via activation of phosphatidylinositol 3-kinase" . : 81
January 2000 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Impairment of mitochondrial oxygen metabolism induced by endotoxin correlates with ultrastructural injury in hepatic mitochondria" . : A880
January 2001 Crouser, E. D.; Julian, M. W.; Blaho, D. V.; Pfeiffer, D. R.."Inhibition of the permeability transition protects against endotoxin-induced mitochondrial injury and respiratory dysfunction" . : A553
January 2001 Crouser, E. D.; Julian, M. W.; Pfeiffer, D. R.."Induction of the permeability transition contributes to mitochondrial injury and altered respiration during endotoxemia" . : 101
January 2002 Gadd, M. E.; Julian, M. W.; Crouser, E. D.; Pfeiffer, D. R.."Analytical quantitation of cytochrome c release from rat liver mitochondria" . : 111a
January 2002 Crouser, E. D.; Gadd, M. E.; Julian, M. W.; Huff, J. E.; Pfeiffer, D. R.."Fractional cytochrome c release from isolated rat mitochondria quantified with reverse-phase HPLC" . : A1184
January 2002 Crouser, E. D.; Julian, M. W.; Joshi, M. S.; Bauer, J. A.."Impaired cardiac contractility is associated with ultrastructurally altered heart mitochondria in acute endotoxemia" . : A472
January 2003 Gadd, M. E.; Crouser, E. D.; Julian, M. W.; Erdahl, W. L.; Huff, J. E.; Pfeiffer, D. R.."Mitochondrial iPLA2 activity promotes release of cytochrome c" . : A678
January 2003 Crouser, E. D.; Julian, M. W.; Morales, J. E.; Joshi, M. S.; Bauer, J. A.."Cardiac dysfunction is associated with myocyte mitochondrial injury in a resuscitated model of acute bacterial sepsis" . : A53
January 2003 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Joshi, M. S.; Bauer, J. A.; Pfeiffer, D. R.."Mitochondrial damage is an early manifestation of sepsis-induced ventricular dysfunction" . : A555
January 2003 Joshi, M.S.; Julian, M. W.; Crouser, E. D.; Bauer, J. A.."Cardiac dysfunction, mitochondrial ultrastructural injury, and NOS2 induction in a feline model of acute sepsis" . : A216
January 2003 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Gadd, M. E.; Erdahl, W. L.; Pfeiffer, D. R.."Abnormal permeability of hepatic outer mitochondrial membranes to cytochrome c during acute endotoxemia" . : A554
January 2004 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Morales, J. E.."A proteomic analysis of liver mitochondria during acute endotoxemia" . : A635
January 2004 Crouser, E. D.; Huff, J. E.; Julian, M. W.; Green-Church, K.."Altered mitochondrial protein expression in the liver during acute endotoxemia" . : A139
January 2004 Joshi, MS, Julia, MW, Crouser, ED, Bauer, JA."Cyclosporin A Prevents Left Ventricular Dysfunction in a Feline Model of Acute Sepsis: Relation to NOS2 Induction, Protein Nitration and Mitochondrial Injury." .
January 2004 Fahy, R. J.; Julian, M. W.; Knoell, D. L.; Crouser, E. D.."Relative to other vital organs, the lung is resistant to injury during the acute phase of bacterial sepsis" . : A635
January 2004 Crouser, E. D.; Cook, C. H.; Julian, M. W.; Huff, J. E.."Hepatic mitochondrial damage, dysfunction and depletion in a murine model of subacute sepsis" . : A636
January 2004 Joshi, M. S.; Julian, M. W.; Crouser, E. D.; Bauer, J. A.."Attenuation of left ventricular dysfunction in a feline model of acute sepsis by cyclosporin A: Relation to TLR4 induction, NOS2 induction and protein nitration" . : 342
January 2004 Crouser, E. D.; Cook, C. H.; Julian, M. W.; Huff, J. E.."Damage and depletion of mitochondria in the liver during sepsis" . : 58A
January 2005 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Struck, J.."Delayed protein release from liver mitochondria during acute sepsis" . : A521
January 2005 Crouser, E. D.; Julian, M. W.; Fahy, R. J.; Knoell, D. R.."The susceptibility to mitochondrial damage differs in vital organs during endotoxemia" . : 45
January 2006 Lucas, D. M.; Hussain, S. R. A.; Johnson, A. J.; Smith, L. L.; Wagner, A. J.; Allison, J. M.; Guster, S. E.; Lin, T. S.; Byrd, J. C.; Julian, M. W.; Crouser, E. D.; Grever, M. R.."Flavopiridol decreases Mcl-1 and initiates early mitochondrial damage in chronic lymphocytic leukemia (CLL) cells" . : 595A
January 2006 Crouser, E. D.; Eng, C.; Wewers, M. D.; Knox, K. S.; Huff, J. E.; Julian, M. W.; Gavrilin, M. A.."Stromal gene expression in mediastinal lymph nodes of sarcoidosis patients" . : A794
January 2007 Knoell, D. L.; Julian, M. W.; Bao, S.; Huff, J. E.; Crouser, E. D.."Sepsis mortality is dramatically increased in zinc deficient mice" . : A437
January 2007 Shao, G.; Julian, M. W.; Huff, J. E.; Wewers, M. D.; Shadel, G. S.; Crouser, E. D.."Highly purified high mobility group proteins do not directly activate peripheral blood monocytes" . : A447
January 2007 Crouser, E. D.; Huff, J. E.; Wewers, M. D.; Knox, K. S.; Ross, P.; Abbas, A.; Eng, C.."Analysis of lung gene expression in sarcoidosis and granulomatous infections" . : A185
November 2008 Raveendran, R.; Hauswirth, D. W.; Crouser, E. D.; Fox, C. C.."Sarcoidosis patients with profound CD4 lymphopenia and opportunistic infections" .
January 2008 Pasadhika, S.; Crouser, E. D.; Harrington, C. A.; Choi, D.; Planck, S. R.; Smith, J. R.; Rosenbaum, J. T.."Microarray gene expression profile of peripheral blood from patients with Sarcoidosis implicates the transcription factor, STAT1" .
November 2009 Erdal, S.; Clymer, B.; Crouser, E. D.."Developing CAD tools for measuring sarcoidosis: Leveraging existing data from a personalized health care perspective" .
May 2009 Crouser, E. D.; Julian, M. W.; Shao, G.; Fox, C. C.; Hauswirth, D. W.; Jehn, J. J.; Lozanski, G.; Erdal, S.; Wewers, M. D.."Infliximab reverses peripheral CD4+ T cell depletion in lymphopenic Sarcoidosis patients" .
November 2009 Erdal, S.; Catalyurek, U.; Krishnamurthy, A.; Kamal, J.; Crouser, E. D.; Clymer, B.."3D haralick texture analysis using CUDA" .
February 2009 Shao, G, Julian, MW, Tridandapani, S, Crouser, ED."Mitochondrial Transcription Factor A (TFAM) Promotes Plasmacytoid Dendritic Cell Activation via Receptor for Advanced Dlycation Endproducts (RAGE" .
May 2010 Crouser, E. D.; Julian, M. W.; Shao, G.."Mitochondrial antigens are selectively recognized by TLR-2 in the context of cell necrosis" .
May 2010 Crouser, E. D.; Shao, G.; Julian, M. W.; Bao, S.."PI-3K is essential for plasmacytoid dendritic cell type I IFN responses to mitochondrial transcription factor A (TFAM) and CpG DNA" .
May 2010 Thacker, M.; Aguda, B.; Crouser, E. D.."In silico modeling of sarcoidosis granuloma formation implicates TNF alpha and regulatory T cells (Tregs) as critical therapeutic targets" .
April 2011 Julian MW, Shao G, Bao S, Crouser ED."PI-3K is Essential for Plasmacytoid Dendtritic Cell Type I IFN Responses to Mitochondrial Danger Signals: Mitochondrial Transcription Factor A (TFAM) and CpG DNA" .
April 2011 Shao G, Julian MW, Boa S, McCullers, Lai JP, MK, Knoell D, Crouser ED."Mitochondrial Protiens Promote Lung Epithelial Wound Closure via Formyl Peptide Receptors" .
May 2012 Leise, B, Watts, M, Crouser, E, Roy, S, Sen, C, Belknap, J."Use of Laser Capture Microdissection for the Assessment of Equine Laminar Basal Epithelial Cell Signaling in the Early Stages of Laminitis" .
May 2012 Teferra, RA, Chacey, M, Crouser, ED."Effective Therapy of Diaphragmatic Sarcoidosis with Adalimumab" .
June 2012 Chang, H, Julian, M, Tran, T, Simonette, P, Billman, GE, Hamlin, R, Crouser, ED, Raman, SV."Modeling At-Risk Myocardium vs Irreversible Injury in Non-ST-Elevation Acute Coronary Syndrome" .
May 2013 Siddiqui, Y, Crouser, ED, Raman, SV."Myocardial Inflammation is Commonly Detected by Cardiac MRI in Critical Care Patients with Sepsis" .
January 2013 Julian, MW, Shao, G, Vangundy, ZC, Papenfuss, TL, Crouser, ED."Mitochondrial Transcription Factor A (TFAM), A Danger Signal Released from Damaged Cells, Promotes an Innate Immune in Through RAGE and TLR9 Signaling Pathways" .
May 2014 Crouser, ED, Wang, K, Nana-Sinkam, SP."Next Generation Sequencing Indetifies a Distinct Plasma Transcriptome Profile in Patients with Active Pulmonary Sarcoidosis" .
January 2014 Julian, MW, Vangundy, ZC, Papenfuss, TL, Crouser, ED."Cross-Suppression of TLR4-and TLR9-Mediated Immune Responses in a Murine Splenocyte Culture Model" .
Crouser, ED, Julian, MW, Strange, HR, Hotchkiss, RS, Ballinger, MN, Papenfuss, TL."TLR4- and TLR9- Mediated Immune Tolerance and Cross-Tolerance is Attenuated by IL-7 Treatment" .

Inventions and Patents

Volumetric Texture Score (Lung texture score based on computerized lung CT scan analysis)

 

Presentations

Acid lung injury results in ileal endothelial injury, but not an abnormal VO2-DO2 relationship in the ileum

Update on Pulmonary Sarcoidosis

Update on Pulmonary Sarcoidosis

Monitoring Tissue Oxygenation and Other Bioenergetic Parameters During Cardiopulmonary Resuscitation

Induction of the permeability transition contributes to mitochondrial injury and altered respiration during endotoxemia

Sepsis-induced Organ Failure: The Role of the Mitochondrial Permeability Transition

Inhibition of the permeability transition attenuates mitochondrial injury and normalizes mitochondrial respiration during endotoxemia

Sarcoidosis Update

Damage and depletion of mitochondria in the liver during CLP sepsis

Mechanisms of organ failure during sepsis

Consequences of the Mitochondrial Permeability Transition in Vital Organs During Acute Sepsis

Genetically determined susceptibility to retained infectious agents in sarcoidosis patients�. (Invited speaker)

The susceptibility to mitochondrial damage differs in vital organs during sepsis

Gauging Sarcoidosis Disease Activity

Resonance between organ injury and inflammation during severe sepsis

Apoptosis and Mitochondrial Permeability Transition Pores

Induction of Inflammation by Mitochondrial Proteins

Sepsis and MODS: The Human Perspective

Pathogenesis of Sepsis-Induced Organ Failures

Exploring the Link between Mitochondria, Metabolism and MODS during Sepsis

Everything you wanted to know about Mitochondria but were afraid to ask

Sepsis and MODS: The Human Perspective

The role of microcirculatory disturbances in pathogenesis of sepsis-induced mutliple organ dysfunction

In Silico modeling of sarcoidosis granuloma formation implicates TNFa and regulatory T cells (Tregs) as critical therapeutic targets

MicroRNA targets the neopterin pathway in pulmonary sarcoidosis

Normal Mitochondrial Function and Pathological Changes

Immune Cells are Critical Sensors of Mitochondrial Danger Signals

Fatal Inflammation Through TLR9 Signaling

Assessing Organ Involvement

Mitochondrial Transcription Factor A (TFAM), A Danger Signal Released from Damaged Cells, Promotes an Innate Immune in Through RAGE and TLR9 Signaling Pathways

Meet the Expert: Sarcoidosis Diagnosis and Treatment

Meet the Expert: Sarcoidosis Diagnosis and Treatment

PAMPs, DAMPs and Immune Physiology

The Role of Hospitalists in the Care of ICU Patients

Metabolic Alterations During Sepsis-Induced Organ Failures

Applying Genomics to Advance Sarcoidosis Treatment: Opportunities and Challenges

Meet the Expert

Bioenergetics, Mitochondrial Dysfunction, and Oxidative Stress in Septic Encephalopathy

Novel Therapies for Pulmonary Sarcoidosis

Novel Biomarkers for Cardiac Sarcoidosis

Clinical Challenges in Sarcoidosis

Next Generation Sequencing Identifies A Distinct Plasma Transcriptome Profile In Patients With Active Pulmonary Sarcoidosis

 

Professional Activities

present Fellowship Grant Review. Mallinckrodt, Inc..
present Sarcoidosis Research Planning Workshop. National Institutes of Health, National Heart, Lung and Blood Institute. Bethesda, MD.
2003 - present Burroughs Wellcome Foundation.
2003 - present The Wellcome Trust (London), Ad Hoc Reviewer.
2004 - present American Lung Association (Ohio Chapter).
2006 - present Davis Heart & Lung Research Institute, Intramural Grants.
2006 - present American Thoracic Society. ATS Meeting.
2007 - present Mentorship of Postdoctoral Fellow. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine.
2013 - present Advisory Board Service. Beckman Coulter.
2013 - present Advisory Board Service. Bristol Meyer Squibb.
2015 - present Advisory Board Service. Mallinckrodt.
2008 Nationwide Children's/OSU Collaborative Grants Review.
2003 - 2009 Society of Critical Care Medicine, Vision Grants.
2005 - 2009 SCCM Meetings. Society for Critical Care Medicine.
2009 NIH- Special Emphasis Panels ZRG1 GGG- F(58) and ZRG1 CVRS-B(58)R.
2010 NIH- Surgery Anesthesiology and Trauma (SAT) Study Section, Ad Hoc.
2011 NIH- ZRG1 SBIB-Q (SAT).
2011 CCTS Intramural Grants- The Ohio State University.
2006 - 2012 Society of Critical Care Medicine (Vision Grants) Reviewer.
2012 KL2 Grant Review- The Ohio State University CCTS Program: 2012.
2014 German Federal Ministry for Education and Research (BMBF); Translational Consortia for Rare Diseases Research- Reviewer.
2013 - 2015 Advisory Board Service. Questcor.
 

Unpublished Works

Lung CT Scan Texture Score Correlates with Disease Severity in Idiopathic Pulmonary Fibrosis

A Feasibility Trial to Detect Sepsis in the Emergency Department Based Upon Blood Monocyte Volume Variability