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Elliott D. Crouser, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: crouser.1@osu.edu

 

Current OSU Appointments

Professor, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep

 

Biographical

Over the past 20 years I have established myself as an internationally recognized expert in two distinct, but scientifically related fields of investigation. My initial interest in research was directed at sepsis, the #1 killer of patients in the medical intensive care units. My contributions to understanding why multiple organs fail, the usual cause of death during sepsis, which were initially published as early as 1995 continue to be recognized as cutting edge and have been confirmed by numerous subsequent studies conducted by other laboratories. I continue to engage in research relating to sepsis, both basic and translational, through extramural grant support. My funding history includes support from The American Heart Association, American Lung Association, and NIH. My sepsis research has led to my involvement in the planning of research programs and international conferences sponsored by the American Thoracic Society and the Society of Critical Care Medicine.

In addition to sepsis, my outpatient clinic has become specialized to care for patients with sarcoidosis. Like sepsis, sarcoidosis is a systemic inflammatory disorder that causes damage and dysfunction of multiple organs. My research in sarcoidosis has been amply funded through extramural agencies (American Thoracic Society, Foundation for Sarcoidosis Research, NIH), and has led to a number of high impact publications. Under my direction, the sarcoidosis program at The Ohio State University is gaining national and international recognition. Based upon my contributions to the field, I have been appointed by the National Heart, Lung and Blood Institute to co-chair a workshop relating to the future of sarcoidosis research.

I graduated from Oberlin College with a major in Geology, after which I worked for a year in a research laboratory at Case Western Reserve’s Rainbow Baby’s and Children’s Hospital. I became committed at that time to a career in medicine and took additional courses at Case Western Reserve University to prepare for medical school. I subsequently enrolled in the Medical College of Ohio in Toledo and received A.O.A. recognition (top ten in my class of over 180 students) during my senior year. I completed an internship and residency in internal medicine and a fellowship in pulmonary and critical care medicine at Ohio State University’s College of Medicine. During my fellowship I received advanced research training in the laboratory of Dr. Paul Dorinsky in the Division of Pulmonary and Critical Care Medicine. I have been a faculty member of the Division and of the Department of Internal Medicine since 1995. My research career was launched while investigating the pathogenesis of organ failures in the context of sepsis but significantly was impacted by Dr. Dorinsky’s departure from academia in 1997, at which time I prematurely assumed a lead role in that laboratory.

Based upon my independent research in the fields of sepsis and mitochondrial biology, as well as my service to the institution, I was promoted to Associate Professor of Internal Medicine on the tenure track in 2006. Since then, I have continued to engage in research of sepsis and related mitochondrial disorders, and I am expanding this area of basic research to include novel experimental clinical trials. I have also developed a new clinical and translational research program relating to systemic sarcoidosis. Under my direction the clinical and research initiatives of the sarcoidosis program at OSU are gaining national and international recognition. The sarcoidosis program is becoming multidisciplinary, and I am collaborating with the Department of Internal Medicine and the Davis Heart and Lung Research Institute to plan the creation of a “Sarcoidosis Center of Excellence”, which will further distinguish the sarcoidosis program through the development of related clinical and translational research missions.

Academic Advising

2011 - present Obada Shaama, The Ohio State University. Mechanisms of Inflammasome Activation Duirng Acute Cell Stress
2013 Douglas Closser,, The Ohio State University. Graduated 0. Computerized CT Image Analysis in Sarcoidosis
2014 Manu Kaushal, Ohio State University College of Medicine. Graduated 0. Risk stratification of cardiac sarcoidosis with MRI
1999 - 2000 Dora Blaho, The Ohio State University. Graduated 2005. Mitochondrial Failure During Endotoxemia
1999 - 2002 Anuj Goyal,, The Ohio State University. Graduated 2002. Monocyte Activation By Akt
2001 - 2003 Juan Morales,, The Ohio State University. Graduated 2003. Proteomic Analysis of Liver Mitochondria During Sepsis
2003 Vandana Potaraju, The Ohio State University. Graduated 2005. Mechanism of Cytochrome c Release During the Mitochondrial Permeability Transition
2002 - 2005 Mandar Joshi, The Ohio State University. Graduated 2005. T32 Project- Mitochondrial FailureDuring Endotoxemia
2003 - 2005 Daniel Iltchev,, The Ohio State University. Graduated 2005. Intracellular Signaling Mechanisms Controlling Monocyte Survival
2003 - 2005 Imad Bouakl,, The Ohio State University. Graduated 2005. Mechanisms of Monocyte Activation by Francisella tularensis
2002 - 2007 Udayan Bhatt,, The Ohio State University. Graduated 2007. Adenoviral Gene Therapy for Diabetic Kidney Disease
2006 - 2009 Meghan McCullers,, The Ohio State University. Graduated 2009. T32 Project- Lung Epithelial Cell Migration in Response to Mitochondrial Antigens
2009 Yu Pei, The Ohio State University. Innate Immune Responses to Mitochondiral Antigens
2008 - 2011 Britta Liese, The Ohio State University. Graduated 2011. Mechanism of Laminitis in Horses
2009 - 2011 Michael Thacker, The Ohio State University. Graduated 2009. In Silico Modeling of T Cell Responses in Sarcoidosis
2008 - 2012 Selnur Erdal, The Ohio State University. Graduated 2012. Development of a High Throughput Integrated Pulmonary Image/Data Interface
2010 - 2012 Michael Chacey,, The Ohio State University. Graduated 2012. The Role of LL37 During Acute Lung Injury
2012 - 2013 Steven Friedenberg, The Ohio State University. Graduated 2013. Mitochondrial Danger Signals in Canine Critical Illness
2012 - 2013 Carleen Risaliti,, The Ohio State University. Computer CT Image Analysis in Idiopathic Pulmonary Fibrosis
2012 - 2014 Yasmin Siddiqui,, The Ohio State University. Graduated 0. Cardiac MRI to Characterzie Acute Myocardial Injury During Severe Sepsis
2012 - 2014 Jennifer Muszynski,, The Ohio State University. Graduated 0. Transfusion-Related Immune Suppression During Critical Illness
2012 - 2015 Henry Chang, The Ohio State University. Graduated 2015. Cardiac MRI to Detect at Risk Myocardium During Non-ST Segment MI
 

Licenses

1992 - present Board Certification: American Board of Internal Medicine
1994 - present Board Certification: American Board of Internal Medicine
1995 - present Board Certification: American Board of Internal Medicine
1995 - present Medical License: State Medical Board of Ohio
2004 - present Board Re-Certification: American Board of Internal Medicine
2004 - present Board Re-Certification: American Board of Internal Medicine
2014 - present Board Re-Certification: American Board of Internal Medicine
 

Clinical Services

01/01/1995 MICU; 4 Doan ICU; OSU East; James,Ross, and UH Consult; Pulmonary Ward; Select; and Risk IP Services (Various Locations Affiliated with The Ohio State University Medical Center)
01/01/1995 Pulmonary Sarcoidosis Outpatient Clinic (Martha Morehouse Medical Pavilion)

Degrees

1983 B.A., Oberlin College

1989 M.D., Medical College of Ohio

 

Editorial Activities

present The Online Journal of Critical Care Medicine
present Biochimica et Biophysica Acta
2004 - 2009 Annals of Surgery (ISI impact factor 6.4)
2004 - 2009 Free Radical Biology and Medicine (ISI impact factor 6.0)
2005 • CHEST (ISI impact factor 5.8; recognized by Editor in Chief as among top 5% of reviewers in 2012)
2005 - 2010 Mitochondrion (ISI impact factor 4.0)
2006 - present Critical Care Medicine
2007 - present Proteomics (ISI impact factor 4.1)
2007 - present Respiratory Medicine (ISI impact factor 2.0)
2007 - present Intensive Care Medicine (ISI impact factor 5.4)
2007 - present Journal of Biological Chemistry (ISI impact factor 4.6)
2007 - present Antioxidants and Redox Signaling (ISI impact factor 7.2)
2007 - present American Journal of Physiology (ISI impact factor 4.2)
2007 - present American Journal of Pulmonary and Critical Care Medicine (ISI impact factor 11.0)
2007 - present Toxicology (ISI impact factor 4.0)
2007 - present BMC Cancer (ISI impact factor 3.3)
2007 - present Lancet (England) (ISI impact factor 39.1)
2007 - present Cell & Tissue Research (ISI impact factor 3.7)
2007 - present Letters in Drug Design and Discovery
2007 Regulatory Toxicology and Pharmacology
2007 Frontiers in Biosciences
2007 “F1000 Medicine” (online journal review)
2007 - 2011 Laboratory Investigation (ISI impact factor 4.0)
2008 - present Critical Care Medicine (ISI Impact Factor 6.4) Recognized as a "Top 10" Reviewer 2008-2013
2008 Shock (ISI impact factor 2.6)
2009 - present International Journal of Interferon, Cytokine, and Mediator Research
2009 American Journal of Physiology-Lung Cellular and Molecular Physiology (ISI impact factor 4.2)
2010 Proteomics (ISI impact factor 4.1)
2011 Molecular Medicine(ISI impact factor 4.5)
2012 Respiratory Medicine (ISI impact factor 2.6)
2014 - present PLOS One
2014 Mucosal Immunology (A Nature Publication; ISI Impact factor 7.0)
2015 European Respiratory Journal
2015 • Circulation: Cardiovascular Imaging (ISI impact factor 5.9)
 

Honors

1988 - 1989 Alpha Omega Alpha. The Medical College of Ohio at Toledo.
1994 - 1995 James V. Warren Award. Department of Medicine, The Ohio State University Department of Internal Medicine.
1999 - 2000 Parker B. Francis Fellow of Pulmonary Research. Harvard School of Public Medicine.
2000 - 2005 Mentored Clinical Scientist Award. National Institutes of Health.
2001 - 2004 Career Investigator Award. American Lung Association.
2005 America's Best Doctors. U.S. News & World Report.
2006 America's Best Doctors. U.S. News & World Report.
2007 America's Best Doctors. U.S. News & World Report.
2008 America's Best Doctors. U.S. News & World Report.
2008 - 2009 Reseracher of the Year. Foundation of Sarcoidsos Research.
2009 Immunology Research Award (top immunology presentation). Society of Critical Care Medicine.
2009 America's Best Doctors. U.S. News & World Report.
2010 America's Best Doctors. U.S. News & World Report.
2011 America's Best Doctors. U.S. News & World Report.
2012 America's Best Doctors. U.S. News & World Report.
2013 Annual Scientific Award (overall top 10 research presentation). Society of Critical Care Medicine.
2013 America's Best Doctors. U.S. News & World Report.
2014 America's Best Doctors. U.S. News & World Report.
2015 - present Best Doctors. Best Doctors.
 

Journal Articles

 

Professional Activities

present Fellowship Grant Review. Mallinckrodt, Inc..
present Sarcoidosis Research Planning Workshop. National Institutes of Health, National Heart, Lung and Blood Institute. Bethesda, MD.
2003 - present Burroughs Wellcome Foundation.
2003 - present The Wellcome Trust (London), Ad Hoc Reviewer.
2004 - present American Lung Association (Ohio Chapter).
2006 - present Davis Heart & Lung Research Institute, Intramural Grants.
2006 - present American Thoracic Society. ATS Meeting.
2007 - present Mentorship of Postdoctoral Fellow. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine.
2013 - present Advisory Board Service. Beckman Coulter.
2013 - present Advisory Board Service. Bristol Meyer Squibb.
2015 - present Advisory Board Service. Mallinckrodt.
2008 Nationwide Children's/OSU Collaborative Grants Review.
2003 - 2009 Society of Critical Care Medicine, Vision Grants.
2005 - 2009 SCCM Meetings. Society for Critical Care Medicine.
2009 NIH- Special Emphasis Panels ZRG1 GGG- F(58) and ZRG1 CVRS-B(58)R.
2010 NIH- Surgery Anesthesiology and Trauma (SAT) Study Section, Ad Hoc.
2011 NIH- ZRG1 SBIB-Q (SAT).
2011 CCTS Intramural Grants- The Ohio State University.
2006 - 2012 Society of Critical Care Medicine (Vision Grants) Reviewer.
2012 KL2 Grant Review- The Ohio State University CCTS Program: 2012.
2014 German Federal Ministry for Education and Research (BMBF); Translational Consortia for Rare Diseases Research- Reviewer.
2013 - 2015 Advisory Board Service. Questcor.