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Beth Besecker, MD

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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: besecker.3@osu.edu


Current OSU Appointments

Assistant Professor, Pulmonary, Crit Care, & Sleep

Physician, FGP-Pulm, Crit Care, & Sleep


Published Works

I have now published work related to zinc metabolism and its relationship to infection in a cell line model, mouse model and human subjects. I continue to pursue this line of investigational research in a translational manner.

Research Funding

I am currently funded by NIH K23 Program (09/13-08/17).

Academic Advising

2013 - present , The Ohio State University.
2002 - 2003 , Riverside Methodist Hospital.
2011 - 2012 Joanna Daigle,, The Ohio State University. Graduated 0.
2009 - 2013 , The Ohio State University.


2001 - present Certification: American Heart Association
2001 - present Certification: American Heart Association
2004 - present Board Certification: American Board of Internal Medicine
2004 - present Medical License: State Medical Board of Ohio
2006 - present Board Certification: American Board of Internal Medicine
2007 - present American Board of Internal Medicine: American Board of Internal Medicine
2011 - present Board Certified Sleep Medicine: American Board of Internal Medicine

Chapters in Books

Zinc in Critical Illness and Sepsis

Dietary and Nutritional Aspects of Zinc in the Critically Ill Adult Patient


Clinical Services

01/01/2009 Pulmonary Consults, ICU and Outpatient Clinic (OSU Hospitals (Main and East) and Clinic)


1998 B.A., University of Toledo

2001 M.D., Medical College of Ohio


Editorial Activities

2008 - present SCCM National Conference
2009 - present CHEST
2010 - present ATS Web Cases
2012 - present Molecular Nutrition and Food Research
2012 - present Critical Care Medicine


2004 Research Citation Finalist, Poster Abstract. Society of Critical Care Medicine.
2007 - 2009 Zinc Importer SLC39A8 and Lung Epithelial Cell Survival. NIH NRSA.
2009 - 2011 Fellow. Center for Clinical and Translational Science.

Journal Articles


Reference Works

January 2002 Beth Besecker, MD."Three Strikes: Kidneys Out" .
January 2005 Beth Besecker, MD."Intrapleural Alteplase for the Complicated Parapneumonic Effusion" .
January 2005 Beth Besecker, MD."Clinical and Financial Analysis of the Impletation of a Sedation Minimization Protocol in the ICU" .
May 2006 Besecker, B, Bao,S, Bohacova,B, et. al.."Modulation of Zinc Transporter RNA Expression by TNFa in Human Lung Epithelia" . : A425
January 2006 Beth Besecker, MD."The Role of Cis-Acting Genetic Regulation on the Human Zinc Transporter SLC39A8-" .
May 2007 Knoell,D, Julian,M, Bao, S, Besecker, B, Huff, J, Crouser, E."Sepsis Mortality Is Dramatically Increased in Zinc Deficient Mice" .
May 2007 Beth Besecker, Shengying Bao, Daren Knoell."Zinc Transporter SLC39A8 is Critical in Lung Epithelial Cell Response to Inflammatory Stress" . : A394
May 2008 Matt Exline, Beth Besecker, Jen Hollyfienld, R Fahy, Mark Wewers."Inflammasome mRNA Expression in Critically-Ill Patients" . : A123
May 2008 Beth Besecker, Matt Exline, Jen Hollyfield, Elizabeth Josephs, Robert DiSilvesro, Daren Knoell."Modulation of Zinc Homeostasis via Zinc Transporters in Humans with Sepsis" . : A120
May 2008 Bao S, Besecker B, Bohacova B, Papp A, Sadee W, Knoell D."The Human Zinc Transporter Zip8 Is Essential in Lung Epithelia Cytoprotection" . : A473
May 2009 Bao S, Liu M, Lee B, Besecker B, Guttridge D, Knoell D."Activation of NF-kB Contributes to Zinc-Deficiency-Enhanced Inflammation" . : A1141
May 2009 Besecker B, Knoell D."Zinc Status Impacts Murine Polymicrobial Sepsis Outcomes" . : A1161
May 2010 Exline M, Sarkar A, Besecker B, Hollyfield J, Mitra S, Wewers M."Inflammasome Constituents Released Via Microvesicles During Sepsis" . : A1378
May 2011 Besecker BY, Zakharova E, Mehta P, Tridandapani S."Zinc Status Impacts Fc Receptor Mediated Bacterial Phagocytosis in Human Monocytes" . : A4535
May 2011 Exline MC, Hollyfield Jl, Besecker BY, O'Brien JM, Ali NA, Gavrilin MA, Wewers MD."Pathogen Sensor NLRP3 Suppressed During Sepsis and Improves During Recovery" . : A2889
May 2012 Exline MC, Hollyfield, Besecker BY, Ali N, O'Brien J, Wewers MD."NOD1 and NOD2 Message Suppressed in Septic Patient Monocytes" . : A5764
May 2012 Besecker BY, Zakharova E, Hollyfield JL, Exline MC."Sepsis Outcomes May Improve in Patients with Improved Plasma Zinc Concentration ICU Day Five" . : A5765
May 2013 Exline MC, Justiniano SE, Hollyfield J, Besecker BY, Ali NA, Mitra S, Wewers MD, Sarkar A."Sepsis Triggers Release of Microvesicles Containing Caspase-1 In Active Form" . : A2786
May 2013 Besecker BY, Kochik S, Tridandipani S, Schlesinger L."Zinc Status Impacts Complement Receptor-Mediated Bacterial Phagocytosis in Human Macrophages" . : A1318
May 2014 Besecker, BY, Kochik, S, Schlesinger, LS."Zinc Deficiency Impairs Bacterial Phagocytosis By Human Macrophages" .


Management of Refractoy Hypoxemia: HFOV and Surfactant

Micronutrients in Critical Illness

Mini-Symposium, ATS International Meeting

Ventilator Liberation

Zinc Supplementation in Critically Ill Septic Patients

Surviving Sepsis Campaign Guidelines-A Review

Immunologic Impact of Zinc Status During Sepsis


Professional Activities

present Poster Symposium. ATS International Meeting.
2007 - present OSUMC Research Day. OSU Medical Center.
2007 - present Resident Applicant Interviews. OSU Medical Center, Department of Internal Medicine.
2008 - present Annual Pulmonary Research Day. OSU Medical Center.
2010 - present Resident Applicant Interviews. OSU Medical Center, Department of Internal Medicine.
2012 - present Resident Applicant Interviews. OSU Medical Center, Department of Internal Medicine.
2009 - 2012 Fellowship Applicant Interviewer.