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Brad H. Rovin, MD - Director


Staff photo

395 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4997

Email: rovin.1@osu.edu

 

Current OSU Appointments

Professor, Nephrology

Professor, Pathology

Physician, FGP-Nephrology

 

Advising Narrative

Rovin, B.H., J. Dickerson, L. Tan, and C. Hebert: Activation of nuclear factor-kappaB correlates with MCP-1 expression by human mesangial cells, Kidney Int., 48:1263-1271, 1995.
Rovin, B.H., L. Lu, and A.M. Cosio: Cyclopentenone prostaglandins inhibit cytokine-induced NF-B activation and chemokine production by human mesangial cells. J. Am. Soc. Nephrol., 12:1659-1667, 2001.

Licenses

1986 - present Board Certification (Diplomate): American Board of Internal Medicine
1988 - present Board Certification (Diplomate): American Board of Internal Medicine
1990 - present Medical Licensure: State Medical Board of Ohio
 

Chapters in Books

Renal Diseases

Depletion of Resident Glomerular Macrophages by Essential Fatty Acid Deficiency Protects against Glomerulonephritis

The role of dietary fatty acides in progressive renal disease

An Outpatient Approach to Proteinuria

Primary Glomerular Diseases

Primary Glomerular Diseases

Glomerular Diseases

The intricate role of complement component C4 in human SLE

Complement components C4A and C4B in human lupus

Complement Deficiencies in Human Systemic Lupus Erythematosus (SLE) and SLE Nephritis: Epidemiology and Pathogenesis

The Kidney in System Lupus Erythematosus

 

Conferences

Flavopiridol administered as a pharmacologically-derived schedule demonstrates marked clinical activity in refractory, genetically high risk, chronic lymphocytic leukemia (CLL)

Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: Tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects

 

Degrees

1978 B.S., Northwestern University

 

Editorial Activities

present The Open Urology and Nephrology Journal
present New England Journal of Medicine
present Journal of Nephrology
present Immunology Today
present Clinical Journal of the American Society of Nephrology
present American Journal of Kidney Disease
present American Heart Journal
present Kidney International
present Journal of Laboratory and Clinical Medicine
present Journal of Clinical Investigation
present ISRN Rheumatology
present Frontiers in Bioscience
present Arthritis and Rheumatism
present American Journal of Physiology
present American Journal of Pathology
present Urology
present Journal of Immunology
present Nephron
present Journal of the American Society of Nephrology
present The Open Urology and Nephrology Journal
present Clinical Immunology and Immunopathology
1996 - 2001 American Journal of Kidney Disease
1998 - present Kidney International
1998 - 2004 Journal of the American Society of Nephrology
2009 - present NIDDK Study Section: Challenge Grant Content Review
2009 - present State of Pennsylvania: Medical Research Grants
2010 - present Clinical Nephrology
 

Honors

present Alpha Omega Alpha. Medical Honor Society.
present William J Grove Award, Outstanding Medical Graduate.
present Omega chi Epsilon. Institute of Chemists Award.
present American Insitute of Chemists Award.
present American College of Physicians.
present James Scholar. College of Medicine.
present American Society of Nephrology.
present Medical Student Research Forum, First Place.
present Alpha Omega Alpha Medical Honor Society.
1989 - 1990 Young Investigator Award.
1994 - 1995 Clinical Scientist Award.
2004 - present Ranked in US News and World Report.
2005 - 2007 America's Best Doctors. U.S. News & World Report.
2007 - 2009 America's Best Doctors.
2008 America's Best Doctor's List.
 

Journal Articles

. -.

 

Reference Works

January 1981 Rovin BH, Molnar J."Role of Plasma Fibronectin in Phagocytosis in Natural Membranous Materials" . : 3309
January 1981 Molnar J, Froehlich J, Rovin BH."Interaction of Plasma Fibronectin with Actin, Intracelular Mammalian Membranous Structures, and Bacteria" . : 849
January 1989 Rovin BH, Lefkowith J, Schreiner G."Glomerular Production of a Chemoattractant for White Blood Cells" . : 361
January 1989 Rovin BH, Lefkowith JB, Schreiner G."Macrophagge Chemotaxis in the Essential Fatty Acid Deficient Rat" . : 361
January 1989 Schreiner G, Rovin BH, Lefkowith J."Essential Fatty Acid Deficiency Inhibits Monocyte Migration in Glomeulonephritis" . : 362
January 1989 Schreiner G, Rovin BH, Lefkowith J."Essential Fatty Acid Deficiency and Monocyte Infiltration in Glomerulonephritis" . : A446
January 1989 Rovin BH, Harris KPG, Morrison A, Klahr S, Schreiner G."The Production of a Novel and Specific Macrophage Chemoattractant in Response to Ureteral Obstruction" . : A613
January 1990 Rovin BH, Lefkowith JB, Schreiner GF."Production of a Lipid Chemoattractant by Glomeruli in Experimental Glomerulonephritis" . : A463
January 1990 Lefkowith JB, Rovin BH, Schreiner GF."Identification of a Chemoattractant Elaborated by Glomeruli in Experimental Glomerulonephritis" . : A891
January 1990 Rovin BH, Wurst E, Kohan DE."Oxygen Free Radical Production by Tubular Epithelial Cells" . : 429
January 1990 Rovin BH, Lefkowith JB, Lange L, Schreiner GF."Glomerular Production of a Lipid Monocyte Chemotactic Factor" . : 536
January 1991 Tan LC, Rovin BH."Production of a Monocyte Chemotactic Factor by Cytokine-conditioned Cultured Human Mesangial Cells" . : 565
January 1991 Rovin BH, Tan LC."Low Density Lipoprotein Stimulates Production of Fibronectin by Human Mesangial Cells in Culture" . : 581
January 1992 Tan L, Rovin BH."Protein Kinase C and cAMP Modulate Monocyte Chemoattractant Protein-1 Expression in Cultured Human Mesangial Cells" . : 617
January 1992 Turman MA, Koch JL, Rovin BH, Cosio FG."Expression of Heat Shock Proteins (HSP) in Human Mesangial Cells (MC)" . : 620
January 1992 Rovin BH, Cosio F, Tan L."Induction of Monocyte Chemoattractant Protein-1 in Human Mesangial Ccells by in situ Immune Complex Formation" . : 612
January 1992 Cosio FG, Birmingham DJ, Rovin BH."Complement Activation Up-regulates Decay Accelerating Factor mRNA Through Multiple Pathways" . : 580
January 1993 Rumancik M, Rovin BH."Glomerular Expression of Monocyte Chemoattractant Protein-1 in Experimental and Human Glomerulonephritis" . : 630
January 1993 Rovin BH, Tan L."Intracellular Regulation of IL-1 Induced Monocyte Chemoattractant Protein-1 in Human Mesangial Cells" . : 498
January 1993 Nahman NS, Rovin BH, Leonhart K."Protein Kinases Modulate Fibronectin Production by Human Mesangial Cells" . : 660
January 1993 Cosio FG, Rovin BH."Complement Induction of Decay Accelerating Factor on Human Mesangial Cells: Signal Transduction Pathways" . : 598
January 1994 Rovin BH, Tan L, Dickerson J."A Regulatory Role for Protein Tyrosine Kinases in IL-1 Mediated Monocyte Chemoattractant Protein-1 Expression by Cultured Human Mesangial Cells" . : 766
January 1994 Rovin BH, Dickerson J, Hebert C, Tan L."NF-6B is Necessary but not Sufficient for IL-1 Induced Monocyte Chemoattractant-1 (MCP-1) Expression by Human Mesangial Cells" . : 766
January 1994 Nahman NS, Deucher M, Epstein D, Turman M, Rovin BH, Kronenberger J, Stauch D, Mathews A, Tan L."Fibronectin Expression in Human Mesangial Cells is Induced by Combined Oxygen-Glucose Deprivation and Regresses with Refeeding" . : 904
January 1995 Rovin BH, Dickerson J, Tan L."Intracellular Glutathione Regulates NF-6B Activation and Monocyte Chemoattractant Protein-1 Expression by Human Mesangial Cells" . : 851
January 1996 Rovin, B.H., W.A. Wilmer, L.C. Tan, J.A. Dickerson, and S.S. Oei."IL-1 Activates Mitogen-Activated Protein Kinase (MAPK) and Stress-Activated Protein Kinase (SAPK) in Human Mesangial Cells (HMC) Through an Oxidation-Dependent Pathway" . : 1684
January 1996 Rovin BH, Tan LC, Wewers MD, Marsh CB."Leukocyte Fc Receptor (FcyR) Cross-linking Induces MCP-1: A Model for Immune-Complex-Mediated Monocyte Recruitment" . : 1718
January 1997 Rovin BH, Allred LK."Expression of Duffy Antigen/Receptor for Chemokines (DARC) During Human Renal Disease" . : 483
January 1997 Rovin, B.H., W.A. Wilmer, M. Danne, and J.A. Dickerson."p38 Mitogen-Activated Protein Kinase is Necessary for IL-1-Induced MCP-1 Expression by Human Mesangial Cells" . : 445
January 1997 Rovin, B.H., M. Danne, M.D. Wewers, and C. Marsh."Lymphocyte Fc Receptor Cross-Linking Mediates Human Renal Cell MCP-1 Production Through an IL-1-Dependent Pathway" . : 484
January 1997 Rovin, B.H., and M. Danne."Nitric Oxide Does not Mediate or Modulate IL-1-Induced MCP-1 Expression by Human Mesangial Cells" . : 444
January 1997 Wilmer WA, Dickerson JA, Rovin BH."Jun-NH2-Terminal Kinase Activation by Protein Phosphatase Inhibition in Human Mesangial Cells" . : 449
January 1998 Rovin BH, Lu L, Saxena DD."Expression of the IL-8 Receptor CXCR1 by Human Renal Parenchymal Cells and the Human Kidney" . : 468
January 1998 Rovin BH, Lu L, Phan LT."Genetic Variation in the MCP-1 Gene Regulatory Region: Association with Lupus Nephritis" . : 467
January 1999 Rovin BH, Lu L, Saxena R."A Novel Polymorphism in the MCP-1 Gene 5'-regulatory Region Influences MCP-1 Expression" . : 536
January 2000 Rovin BH, Lu L, Wang Y."Regulation of Mesangial Cell Chemokine Expression Through Endogenous Anti-inflammatory Mechanisms" . : 498A
January 2000 37. Panzer, U., A. Schneider, U. Wenzel, P. Barth, J. Becker, G. Zahner, U. Helmchen, B. Rovin, F.P. Schena, D. Cusi, G.D’Amico, F. Berthoux, R.A.K. Stahl."The chemokine receptor CCR-532 mutation is associated with better renal function in patients with IgA nephropathy" . : 94A
January 2000 Wilmer WA, Rovin BH, Dixon CL, Lu L."Peroxisome Proliferator-activated Receptors (PPARs) Induce the Extracellular-regulated Kinases (ERKs) in Human Mesangial Cells (HMC)" . : 436A
January 2000 Bhatt UY, Plott DT, Fu J, Rovin BH, Nahman NS."Bone Marrow Engraftment and Acute Renal Failure" . : 126A
January 2000 Rovin BH, Lu L."Role of Chemokine Polymorphisms in Determining the Severity of Renal Inflammation in SLE" . : 96A
January 2001 Rovin, B.H., W.A. Wilmer, L. Lu, C. Dixon, A.I. Doseff, and T. Hilbelink."The cyclopentenone prostaglandin 15-deoxy-12,14-PGJ2 regulates human mesangial cell proliferation and survival" . : 620A
January 2001 Wilmer, W.A., C. L. Dixon, L. Lu, and B.H. Rovin."J-series prostaglandins and ciglitazone inhibit TGF-1 expression by human mesangial cells" . : 720A
January 2002 Rovin, B.H., L. Lu, C. L. Dixon, W.A. Wilmer, and J.B. Klein."Mesangial expression of heat shock protein 70 in response to treatment with 15-deoxy-12,14-prostaglandin J2 is a defense mechanism against cell death" . : 293A
January 2002 Yang Y, Chung EK, Tsao BP, Zhou B, Higgins G, Rennebohm RM, Birmingham DJ, Rovin BH, Hebert LA, Yu CY."A Quantitative Genetic Trait for Human Lupus: Low and High Gene Dosages of Complement C4 in SLE Patients" . : 12A
January 2002 Rovin BH, Lu L, Zhang X."A Novel Interleukins-8 Polymorphism is Associated with Severe SLE Nephritis" . : 514A
January 2003 Rovin, B.H., X. Zhang, W.A. Wilmer, L. Lu, C. Dixon, H. Song, and X. Chen."Pathways of stress protein activation in 15-deoxy-12,14-prostaglandin J2" . : 84A
January 2003 Thongboonkerd V, Barati M, McLeish KR, Rovin BH, Pierce WM, Epstein PN, Klein JB."Altered Elastase Inhibitor and Elastin Expression in Type 2 Diabetic Kidneys Defined by Proteomic Analysis" . : 600A
January 2003 Chung EK, Rovin BH, Lu L, Yang Y, Yu CY."Differential Expression of Complement Components C4A and C4B in Human Kidney Cells" . : 634A
January 2004 Rovin BH, Song H, Birmingham DJ, Hebert LA, Yu CY, Nagaraja HN."Urine Chemokines as Biomarkers of Human SLE Activity" . : 54A
January 2004 Rovin BH, Zhang X, Chen HZ, Chen XL, Song H."A Novel Regulator of Chemokine Expression: Linking Oxidative Stress to Inflammation" . : 474A
January 2005 Rovin BH, Song H, Hebert LA, Nadasdy T, Nadasdy G, Birmingham DJ, Yu CY, Nagaraja HN."Expression of Adiponectin in Human Lupus Nephritis" . : 7A
January 2005 Rovin BH, Campbell S, Kollaros M, Burkly L, Michaelson J, Putterman C."Urinary Tweak in Systemic Lupus Erythematosus: A Novel Biomarker for Lupus Nephritis?" . : S198
January 2005 Hebert LA, Rovin BH, Nagaraja HN, Birmingham DJ, Spetie L."Association of SLE Flare with Increased Self-perceived Stress Variability" . : 528A
January 2006 Nadasdy, T., G. Nadasdy, G. Agarwal, A. Satoskar, M. Mauer, A. Agarwal, D. Spetie, B.H. Rovin, and L.A. Hebert."Idiopathic thick glomerular basement membrane nephropathy: A newly recognized cause of glomerular hematuria" . : 258A
January 2006 Khanna, B., C. Valentine, H.N. Nagaraja, B.H. Rovin, and L.A. Hebert."Fenofibrate-induced increase in serum creatinine in chronic kidney disease does not appear to be the result of nephrotoxicity or increased creatinine production" . : 384A
January 2006 Birmingham, D.J., H.N. Nagaraja, B.H. Rovin, L. Spetie, Y. Zhao, X. Li, K.V. Hackshaw, C.Y. Yu, W.B. Malarkey, and L.A. Hebert."Fluctuation in self-perceived stress increases risk of flare in SLE nephritis patients carrying the 5-HT1A-1019 Allele" . : 731A
January 2006 Yang, Y., L.A. Hebert, E.K. Chung, H.N. Nagaraja, Y.L. Wu, B. Zhou, M. Hebert, K. Hackshaw, D.J. Birmingham, B.H. Rovin, and C.Y. Yu."Caucasian patients with systemic lupus erythematosus nephritis have low C4A gene copy numbers and low plasma C4 protein levels" . : 801A
January 2006 Yang, Y., E.K. Chung, Y.L. Wu, H.N. Nagaraja, B. Zhou, M. Hebert, K. Jones, B.P. Tsao, D.J. Birmingham, B.H. Rovin, L.A. Hebert, and C.Y. Yu."Complement C4 gene copy number variation in human autoimmune disease systemic lupus erythematosus" . : 265A
January 2006 Schwartz N, Su L, Burkly LC, gao HX, Aranow C, Mackay M, Michaelson JS, Rovin BH, Putterman C."Urinary TWEAK is a Novel Biomarker for Lupus Nephritis" . : S456
January 2006 Rovin BH, Nadasdy G, Nuovo G, Song H, Nadasdy T."Expression of Adiponectin and its Receptors in the Kidney During SLE Nephritis" .
January 2006 Roncone D, SOng H, Cooke G, Rovin BH."Identification of the Apolipoprotein E Kyoto Mutation in a Caucasian American with Lipoprotein Glomerulopathy" .
January 2006 Appel GB, Looney RJ, Eisenberg RA, Rovin BH, Ginzler EM, Adler SG, Brunetta P, Garg JP."Protocol for the Lupus Nephritis Assessment with Rituximab (LUNAR) Study" .
January 2007 Rovin, B.H., D.J. Birmingham, H. Nagaraja, C.Y. Yu, and L.A. Hebert."Evaluation of the performance of traditional biomarkers for the diagnosis or prediction of renal flare in patients with lupus nephritis" . : 779A
January 2007 Hebert, L.A., B.H. Rovin, G. Shidham, D.J. Birmingham, and H.N. Nagaraja."Relationship between albuminuria and total proteinuria in SLE GN: Diagnostic and therapeutic implications" . : 566A
January 2007 Plott, D.T., D.J. Birmingham, B.H. Rovin, L.A. Hebert, and U.Y. Bhatt."Association of air quality index and renal flares of systemic lupus erythematosus" . : 823A
January 2007 Zhang, X., M. Jin, H. Wu, N. Harris, H. Nagaraja, D. Birmingham, C.Y. Yu, and B.H. Rovin."Biomarker discovery for lupus nephritis using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry" . : 789A
January 2007 Rovin, B.H., H. Wu, D.J. Birmingham, N. Haddad, L.A. Hebert."Relationship between the level of high sensitivity D-dimer and the risk of clotting in SLE" . : 630A
January 2007 Hebert, L.A., B.H. Rovin, G. Shidham, D.J. Birmingham, H.N. Nagaraja."To reliably estimate 24-hour proteinuria to diagnose SLE GN flare, the protein/creatinine ratio of an intended 24-hour urine collection that is 50% or more complete is better than a spot urine protein/creatinine ratio" . : 556A
January 2007 Chellini, J., C. Valentine, B.H. Rovin, and L.A. Hebert."In chronic kidney disease patients fenofibrate-induced increases in serum creatinine are reversible despite years of fenofibrate therapy" . : 553A
January 2007 Yu, C.Y., Y. Yan, Y.L. Wu, N. Esack, A. Aziz, L.S. Hiremath, K.V. Hackshaw, D.J. Birmingham, B.H. Rovin, H.N. Nagaraja, and L.A. Hebert."Relevant genetic and clinical predictors of complement C4 protein levels and SLE disease flares" . : 780A
January 2007 Bhatt, U.Y., D.J. Birmingham, B.H. Rovin, and L.A. Hebert."Seasonal variation in renal and non-renal systemic lupus erythematosus flares" . : 825A

Presentations

Visiting Professor

Visiting Professor

Activation of Nuclear Factor-6B Correlates with IL-1-induced Monocyte Chemoattractant Protein-1 Expression by Human Mesangial Cells

Visiting Professor

Visiting Professor

Visiting Professor

Visiting Professor

Visiting Professor

Visiting Professor

Visiting Professor

Visiting Professor/Consultant

Visiting Professor

Urinary Chemokines as Biomarkers of SLE Activity

Visiting Professor

Visiting Professor

Visiting Professor

Second Annual Susac’s Syndrome Seminar

Visiting Professor

Visiting Professor

Faculty Member for Seminar in Advanced Rheumatology

Visiting Professor

Visiting Professor

Second International Lupus Flare Conference

Quality Indicators for Lupus Workshop

Biannual SLE Research Conference

Visiting Professor

Visiting Professor

Visiting Professor

Mayo Clinic International Seminar in Nephrology

Grand Rounds Speaker

Basic Scientists and Clinicians-Get Connected

Visiting Professor

Visiting Professor

First Imperial College and Transplant Institute Lupus Meeting

 

Professional Activities

1995 - present Medical Research Council.
1995 - present National Research Council.
1995 - present Canadian Research Council.
1995 - present Veterans Administration Merit Review Board.
1995 - present National Kidney Foundation Fellowship Review Committee.
2002 - present SCORs in SLE. NIAMS Study Section.
2004 - present Pathobiology of Kidney Disease. NIDDK Study Section.
2005 - present Clinical Studies of Kidney Diseases. NIDDK Study Section.
2005 - present Program Projects in SLE. NIAID Study Section.
2007 - present George O’brien Kidney Center Awards. NIDDK Study Section.
2007 - present Pathobiology of Kidney Disease. NIDDK Study Section.
2008 - present George O’brien Kidney Center Awards. NIDDK Study Section.
2008 - present Biannual SLE Research Conference. University of California, San Francisco.
2008 - present Second International Lupus Flare Conference. Washington, DC.
2008 - present Quality Indicators of Lupus Workshop. San Francisco, CA.
2009 - present Challenge Grant Content Review. NIDDK Study Section.
2009 - present American Society of Nephrology Grant Review Committee.
2010 - present Osperey Pharmaceuticals.
2010 - present Questcor Pharmaceuticals.
2010 - present Genetech.
2010 - present Teijan Pharmaceuticals.
2010 - present Centocor Research and Development.
2010 - present Novo Nordisk.
2010 - present Veterans Administration Merit Review Board.
 

Technical Reports

Arthritis & Rheumatism

Biomarker discovery in human SLE nephritis