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Lee A. Hebert, MD

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395 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4997

Email: hebert.1@osu.edu


Current OSU Appointments

Faculty Emeritus, Nephrology

Professor, Pathology

Physician, FGP-Nephrology



1970 - present Board Certification (Diplomate): American Board of Internal Medicine
1974 - present Board Certification (Diplomate): American Board of Internal Medicine

Chapters in Books

Yu, C.Y., G. Hauptmann, Y. Yang, Y.L. Wu, D.J. Birmingham, B.H. Rovin, and L.A. Hebert. "Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis: epidemiology and pathogenesis." In Systemic Lupus Erythematosus: A Companion to Rheumatology. Edited by Tsokos, G.C., Gordon, C., and Smolen, J.S.. 183-193. Philadelphia, PA: Elsevier, January 2007.

Haddad, N., Brown, C., Hebert, L.A.. "Retarding progression of kidney disease." In Comprehensive Clinical Nephrology. 3 ed. Edited by Johnson, R., Fehally, J.. 823-830. Philadelphia, PA: Elsevier, January 2007.



present Named to the Committee of the International Society of Nephrology and the American Society of Nephrology.
1996 - 2007 America's Best Doctors.

Journal Articles

Hebert, L, A; Kusek, J, W; Greene, T; Agodoa, L, Y; Jones, C, A; Levey, A, S; Breyer, J, A; Faubert, P; Rolin, H, A; Wang, S R. "Effects of blood pressure control on progressive renal disease in blacks and whites. Modification of Diet in Renal Disease Study Group.." Hypertension. Vol. 30, no. 3 Pt 1. (January 1997.): 428-35.

Agarwal, A; Clements, J; Sedmak, D, D; Imler, D; Nahman, N S Jr; Orsinelli, D, A; Hebert, L A. "Subacute bacterial endocarditis masquerading as type III essential mixed cryoglobulinemia.." Journal of the American Society of Nephrology : JASN. Vol. 8, no. 12. (January 1997.): 1971-6.

Hebert, L, A; Birmingham, D, J; Mahan, J, D; Cosio, F, G; Dillon, J, J; Sedmak, D, D; Shen, X, P; McAllister, C. "Effect of enalapril therapy on glomerular accumulation of immune complexes and mesangial matrix in experimental glomerulonephritis in the nonhuman primate.." American journal of kidney diseases : the official journal of the National Kidney Foundation. Vol. 30, no. 2. (January 1997.): 243-52.

Wilmer, W, A; Hebert, L, A; Lewis, E, J; Rohde, R, D; Whittier, F; Cattran, D; Levey, A, S; Lewis, J, B; Spitalewitz, S; Blumenthal, S; Bain, R P. "Remission of nephrotic syndrome in type 1 diabetes: long-term follow-up of patients in the Captopril Study.." American journal of kidney diseases : the official journal of the National Kidney Foundation. Vol. 34, no. 2. (January 1999.): 308-14.

Hebert, L, A; Falkenhain, M, E; Nahman, N S Jr; Cosio, F, G; O'Dorisio, T M. "Combination ACE inhibitor and angiotensin II receptor antagonist therapy in diabetic nephropathy.." American journal of nephrology. Vol. 19, no. 1. (January 1999.): 1-6.

Hebert, L A. "Target blood pressure for antihypertensive therapy in patients with proteinuric renal disease.." Current hypertension reports. Vol. 1, no. 5. (January 1999.): 454-60.

Cattran, D, C; Appel, G, B; Hebert, L, A; Hunsicker, L, G; Pohl, M, A; Hoy, W, E; Maxwell, D, R; Kunis, C L. "A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis. North America Nephrotic Syndrome Study Group.." Kidney international. Vol. 56, no. 6. (January 1999.): 2220-6.

Birmingham, D, J; Hebert, L, A; Shen, X, P; Higgins, P; Yeh, C, G; Creasey, A A. "Effects of immune complex formation and complement activation on circulating platelets in the primate.." Clinical immunology (Orlando, Fla.). Vol. 91, no. 1. (January 1999.): 99-105.

Dooley, M, A; Cosio, F, G; Nachman, P, H; Falkenhain, M, E; Hogan, S, L; Falk, R, J; Hebert, L A. "Mycophenolate mofetil therapy in lupus nephritis: clinical observations.." Journal of the American Society of Nephrology : JASN. Vol. 10, no. 4. (January 1999.): 833-9.

Hebert, L, J; Moffet, H; McFadyen, B, J; St-Vincent, G. "A method of measuring three-dimensional scapular attitudes using the optotrak probing system.." Clinical biomechanics (Bristol, Avon). Vol. 15, no. 1. (January 2000.): 1-8.

Hebert, L, A; Agarwal, G; Sedmak, D, D; Mahan, J, D; Becker, W; Nagaraja, H N. "Proximal tubular epithelial hyperplasia in patients with chronic glomerular proteinuria.." Kidney international. Vol. 57, no. 5. (January 2000.): 1962-7.

Agodoa, L, Y; Appel, L; Bakris, G, L; Beck, G; Bourgoignie, J; Briggs, J, P; Charleston, J; Cheek, D; Cleveland, W; Douglas, J, G; Douglas, M; Dowie, D; Faulkner, M; Gabriel, A; Gassman, J; Greene, T; Hall, Y; Hebert, L; Hiremath, L; Jamerson, K; et al.. "Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.." JAMA : the journal of the American Medical Association. Vol. 285, no. 21. (January 2001.): 2719-28.

Cattran, D, C; Appel, G, B; Hebert, L, A; Hunsicker, L, G; Pohl, M, A; Hoy, W, E; Maxwell, D, R; Kunis, C, L; Kunis, C L. "Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial.." Kidney international. Vol. 59, no. 4. (January 2001.): 1484-90.

Hebert, L, A; Spetie, D, N; Keane, W F. "The urgent call of albuminuria/proteinuria. Heeding its significance in early detection of kidney disease.." Postgraduate medicine. Vol. 110, no. 4. (January 2001.): 79-82, 87.

Birmingham, D, J; Rovin, B, H; Yu, C, Y; Hebert, L A. "Of mice and men: the relevance of the mouse to the study of human SLE.." Immunologic research. Vol. 24, no. 2. (January 2001.): 211-24.

Birmingham, D, J; Hebert, L A. "CR1 and CR1-like: the primate immune adherence receptors.." Immunological reviews. Vol. 180, (January 2001.): 100-11.

Hebert, L, A; Wilmer, W, A; Falkenhain, M, E; Ladson-Wofford, S, E; Nahman, N S Jr; Rovin, B H. "Renoprotection: one or many therapies?." Kidney international. Vol. 59, no. 4. (January 2001.): 1211-26.

Wright, Jackson T Jr; Bakris, George; Greene, Tom; Agodoa, Larry, Y; Appel, Lawrence, J; Charleston, Jeanne; Cheek, DeAnna; Douglas-Baltimore, Janice, G; Gassman, Jennifer; Glassock, Richard; Hebert, Lee; Jamerson, Kenneth; Lewis, Julia; Phillips, Robert, A; Toto, Robert, D; Middleton, John, P; Rostand, Stephen, G; Rostand, Stephen G. "Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.." JAMA : the journal of the American Medical Association. Vol. 288, no. 19. (January 2002.): 2421-31.

Weening, Jan, J; D'Agati, Vivette, D; Schwartz, Melvin, M; Seshan, Surya, V; Alpers, Charles, E; Appel, Gerald, B; Balow, James, E; Bruijn, Jan, A; Cook, Terence; Ferrario, Franco; Fogo, Agnes, B; Ginzler, Ellen, M; Hebert, Lee; Hill, Gary; Hill, Prue; Jennette, J Charles; Kong, Norella, C; Lesavre, Philippe; Lockshin, Michael; Looi, Lai-Meng; et al.. "The classification of glomerulonephritis in systemic lupus erythematosus revisited.." Kidney international. Vol. 65, no. 2. (January 2004.): 521-30.

Lea, Janice; Greene, Tom; Hebert, Lee; Lipkowitz, Michael; Massry, Shaul; Middleton, John; Rostand, Stephen, G; Miller, Edgar; Smith, Winifred; Bakris, George L. "The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: results of the African American study of kidney disease and hypertension.." Archives of internal medicine. Vol. 165, no. 8. (January 2005.): 947-53.

Rovin BH, Song H, Hebert LA, Nadasdy T, Nadasdy G, Birmingham DJ, Yu CY, Nagaraja HN. "Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus." Kidney International. Vol. 68, (January 2005.): 1825-1833.

Hui W, Cantor RM, Cunninghame-Gramham D, et al including Hebert LA. "Association Analysis of theR620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 in systemic lupus families: Increased Tallele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease." Arthritis & Rheumatism. Vol. 52(8), (January 2005.): 2396-2402.

Hebert LA, Rovin BH, Agarwal AK, Spetie DN.. "Cyclephosphamide or Chlorambucil Therapy is indicated in Idiopathic Membranous Nephropathy with Strong Risk Factors for Progression.." American Journal of Kidney Diseases. Vol. 45, (January 2005.): 788-789.

Rovin BH, Tang Y, Sun J, Nagaraja HN, Hackshaw KV, Gray L, Rice R, Birmingham DJ, Yu CY, Spetie DN, Aziz A, Hebert LA. "Clinical Significance of Fever in the SLE Patient Receiving Steroid Therapy." Kidney International. Vol. 68, (January 2005.): 747-759.

Rovin BH, Song H, Birmingham DJ, et al including Hebert L. "Urine Chemokines as Biomarkers of Human SLE Activity." Journal of the American Society of Nephrology. Vol. 16, (January 2005.): 467-473.

Hebert CJ, Shidham G, Hebert LA,. "Should the Target for Blood Pressure Control specify both a Systolic and Diastolic Component." Current Hypertension Reports. Vol. 7(5), (January 2005.): 360-362.

Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Yu CT, Malarkey B, Hebert LA. "Fluctuation in self-perceived stress increases risk of flare in SLE nephritis patients carrying the 5-HT - 1019G allele.." Arthritis & Rheumatism. Vol. 54, (January 2006.): 3291-9299.

Spetie DN, Nadasdy T, Nadasdy G, Agarwal G, Mauer M, Agarwal AK, Khabiri, Nagaraja HN, Nahman Jr NS, Hartman, JA, Hebert LA. "Proposed pathogenesis of idiopathic loin pain-hematuria syndrome.." American Journal of Kidney Disease. Vol. 47(3), (January 2006.): 419-427.

Wenzel UO, Hebert LA, Stahl RAK. Krenz I. "My doctor said I should drink a lot! Recommendations for fluid intake in patients with chronic kidney disease." Clinical Journal of the American Society of Nephrology. Vol. 1, (January 2006.): 344-346.

Julius S, Nesbitt SD, Egan BM, et al, including Hebert Lee. "Trial of Preventing Hypertension (TROPHY) Study Investigators: Feasibility of tresting prehypertension with an angiotensin-receptor blocker." New England Journal of Medicine. Vol. 354, (January 2006.): 1685-97.

Birmingham, D, J; Gavit, K, F; McCarty, S, M; Yu, C, Y; Rovin, B, H; Nagaraja, H, N; Hebert, L A. "Consumption of erythrocyte CR1 (CD35) is associated with protection against systemic lupus erythematosus renal flare.." Clinical and experimental immunology. Vol. 143, no. 2. (January 2006.): 274-80.

Dr. Satoskar AA, Nadasdy G, Plaza JA, Sedmak D, Shidham G. Hebert LA, Nadasdy T. "Staphylococcus infection-associated glomerulonephritis mimicking IgA nephropathy." Clinical Journal of the American Society of Nephrology. Vol. 1, (January 2006.): 1179-1186.

Norris, Keith; Bourgoigne, Jacque; Gassman, Jennifer; Hebert, Lee; Middleton, John; Phillips, Robert, A; Randall, Otelio; Rostand, Stephen; Sherer, Susan; Toto, Robert, D; Wright, Jackson T Jr; Wang, Xuelei; Greene, Tom; Appel, Lawrence, J; Lewis, Julia; Lewis, Julia. "Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial.." American journal of kidney diseases : the official journal of the National Kidney Foundation. Vol. 48, no. 5. (January 2006.): 739-51.

Haddad, N., Rajan, F., Nagaraja, H.N., Agarwal, A.K., Hebert, L.A.. "Usual ACE inhibitor therapy in CKD patients is associated with lower plasma aldosterone levels than usual angiotensin receptor blocker therapy." Kidney and Blood Pressure Research. Vol. 30, (January 2007.): 299-305.

Satoskar, A.A., Burdge, K., Cowden, D.J., Nadasdy, G.M., Hebert, L.A., Nadasdy, T.. "Typing of amyloidosis in renal bipsies: diagnostic pitfalls." Archives of Pathology and Laboratory Medicine. Vol. 131, (January 2007.): 917-922.

Wang, L., S. Lin, K.W. Rammohan, Z. Liu, J.-Q. Liu, R.-H. Liu, N. Guinther, J. Lima, Q. Zhou, T. Wang, Z. Zheng, D.J. Birmingham, B.H. Rovin, L.A. Hebert, Y. Wu, J. Lynn, G. Cooke, C.Y. Yu, P. Zheng, and Y. Liu. "A di-nucleotide deletion in CD24 confers protection against autoimmune diseases." PLoS Genetics. Vol. 3e:49, (January 2007.): -.

Hebert, L.A., B.H. Rovin, and C.J. Hebert. "The design of the ALLHAT may have biased the study’s outcome in favor of the diuretic cohort." Nature Clinical Practice Nephrology. Vol. 3, (January 2007.): 60-61.

Yang, Y., E.K. Chung, Y.L. Wu, S. Savelli, H.N. Nagaraja, B. Zhou, M. Hebert, K. Jones, Y. Shu, K. Kitzmiller, C.A. Blanchong, N. Jacobsen-Longman, K. McBride, G.C. Higgens, R.M. Rennebohm, R.R. Rice, K.V. Hackshaw, R.A. Roubey, J.M. Grossman, B.P. Tsao,. "Gene copy number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus: Low copy number is a risk factor for, high copy number is a protective factor against, Caucasian SLE disease susceptibility." American Journal of Human Genetics. (January 2007.): 1037-1054.

Wu, Y.L., S.L. Savelli, Y. Yang, B. Zhou, B.H. Rovin, D.J. Birmingham, H.N. Nagaraja, L.A. Hebert, and C.Y. Yu. "Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short and RCCX modules: Elucidation of C4 CNVs in 50 consanguineous subjects with defined HLA." Journal of Immunology. Vol. 179, (January 2007.): 3012-3025.

Wu H., S.A. Boackle, P. Hanvivadhanaku, D. Ulgiati, J.M. Grossman, Y. Lee, N. Shen, L.J. Abraham, T.R. Mercer, E. Park, L.A. Hebert, B.H. Rovin, D.J. Birmingham, D. Chang, C.J. Chen, D. McCurdy, H.M. Badsha, B.Y.H. Thong, H.H. Chng, F.C. Arnett, D.J. Wall. "Association of a common complement receptor 2 haplotype with increased risk of SLE." Proceedings of the National Academy of Science. Vol. 104, (January 2007.): 3961-3966.

Rovin, B.H. and L.A. Hebert. "Thiazide monotherapy for hypertension: Thiazide’s dark side just got darker." Kidney International. Vol. 72, (January 2007.): 1423-1426.

Birmingham, D.J., B.H. Rovin, G. Shidham, H.N. Nagaraja, X. Zou, M. Bissel, and L.A. Hebert. "Spot urine protein/creatinine ratios are unreliable estimates of 24 hour proteinuria in most systemic lupus erythematosus nephritis flares." Kidney International. Vol. 72, (January 2007.): 865-870.