Ohio State Navbar


Dan Birmingham, PhD

Staff photo

395 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4997

Email: birmingham.1@osu.edu


Current OSU Appointments

Senior Research Scientist, Nephrology

Faculty Emeritus, Nephrology


Academic Advising

2011 - present Terese Gullo, Ohio State University College of Medicine.
2012 - present Nicole Reyes, The Ohio State University. T cell transcript changes during lupus nephritis flare
2006 - 2009 Kathryn Kitzmiller, The Ohio State University. Graduated 2009. Gene copy number variation in complement factor H

Chapters in Books

Circulating immune complexes

The role of complement in glomerular and vascular injury

The type one complement receptor (CR1) and human SLE

Complement and complement regulatory proteins in renal disease

Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis

Complement components C4A and C4B in human lupus.

Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis: epidemiology and pathogenesis

Complement Regulation in the Kidney

Renal Involvement in Systemic Lupus Erythematosus

Systemic Lupus Nephritis and the Kidney



1978 B.S., The Ohio State University

1981 M.S., The Ohio State University

1989 Ph.D., The Ohio State University


Editorial Activities

present Clinical Immunology and Immunopathology
present Archives of Biochemistry and Biophysics
present Trends in Molecular Medicine
present Scandinavian Journal of Immunology
present Journal of Clinical Immunology
present Arthritis Research & Therapy
present Journal of Immunological Methods
1999 - present J of Immunol
1999 - 2004 Journal of Immunology
2000 - present Genes and Immunity
2004 - present J Am Soc Neph
2005 - present Arthritis and Rheumatism
2008 - present Kidney International

Journal Articles

"Prevention of acute murine cardiac allograft rejection: Anti-CD4 or anti-vascular cell adhesion molecule one monoclonal antibodies block acute rejection but permit persistent graft-reactive alloimmunity and chronic tissue remodelling." JOURNAL OF HEART AND LUNG TRANSPLANTATION. Vol. 16, no. 9. (September 1997.): -.


Reference Works

January 1989 Birmingham DJ, Cosio FG."C3b binding proteins of primate erythrocytes (E)" . : 315A
January 1990 Birmingham DJ, Cosio FG."Determination of factor I cofactor function of nonhuman primate erythrocyte (E) C3b receptors" . : A2188
January 1991 Birmingham DJ, Cosio FG, McCourt DW, Atkinson JP."N-terminus amino acid analysis of the baboon erythrocyte C3b receptor" . : A1716
January 1993 Birmingham DJ, Atkinson JP."Identification of an alternatively spliced transcript of the chimpanzee type one complement receptor (CR1)" . : 224A
January 1996 Birmingham, D.J., Logar, C.M., Shen, X.P."Baboon CR1b, a homologue of the human CR1-like element, encodes the baboon erythrocyte complement receptor" .
January 1997 Logar CM, Birmingham DJ."CR1-like, a C3b binding protein of non-human primate erythrocytes, is expressed in human bone marrow" .
January 1998 Birmingham DJ, Moulds JM, Chen W."A CR1 polymorphism associates with the B allele and with SLE patients" .
January 1998 Birmingham DJ, Chen W, Shen XP."Certain mutations of CR1 segregate with normals or SLE patients with nephritis" .
January 1998 Allred LK, Birmingham DJ."Polymorphisms of FcRIIIa and the associated  subunit in normals and SLE patients" .
January 1999 Birmingham DJ, Chen W, Shen XP, Liang G."A CR1 polymorphism associates with SLE Nephritis and Juvenile-onset IgA Nephritis" . : 304
January 2000 Birmingham DJ, Liang G, Shen XP."CR1 polymorphisms associated with SLE" . : 29
January 2000 Birmingham DJ, Logar CM, Chen W."Characterization of the human CR1-like transcript" . : 11
January 2001 Birmingham DJ, Chen W, Liang G, Schmitt HC."A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians" .
January 2002 Logar CM, Chen W, and Birmingham DJ."Human CR1-like express a transcript in bone marrow for a C4b binding protein" .
January 2002 Birmingham DJ, Chen W, Schmitt HC, Gavit K."A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b" .
January 2004 Birmingham DJ, Gavit KF, McCarty S, Yu CY, Rovin BH, Hebert, LA."Erythrocyte CR1 levels and SLE flare" .
January 2004 Irshaid F, Yu CY, Birmingham DJ."Human fetal liver and bone marrow express a transcript that encodes the two N terminal SCRs of CR1-like" .
January 2004 Gavit KF, Tong J, Nagaraja HN, Birmingham DJ."Two CR1 polymorphism in SCR 8 independently affect binding to C4b and/or C3b" .
January 2004 Gavit KF, Nagaraja HN, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Erythrocyte CR1 levels and SLE flare" .
January 2005 Birmingham, DJ. Gavit KF, McCarty S, Tong J, Yu CY, Rovin BH, Nagaraja HN, Hebert, LA."Consumption of erythrocyte CR1 is associated with protection against SLE renal flare" .
January 2006 Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Malarkey WB, Hebert LA."Fluctuation in Self-Perceived Stress Increases Risk of Flare in SLE Nephritis Patients Carrying the 5-HT1A-1019G Allele" .
January 2007 Birmingham DJ, Rovin BH, Zou X, Yu CY, Tsao BP, Wu H, Nagaraja HN, Hebert LA."Multivariate Analysis of Traditional Biomarkers Identifies Markers and Forecasters of Lupus Nephritis Flare" .
January 2010 Birmingham DJ, Hebert LA, Song H, Nagaraja HN, Noonan WT, Rovin BH, Yu CY."Evidence that Decline in Vitamin D Status may be Mechanistically Related to SLE Flare" .
January 2010 Birmingham DJ, Shen XP."Identification of a CR1-like transcript in the baboon bone marrow" .
January 2010 Bitter J, Dials S, Nagaraja HN,, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Changes in Anti-C1q IgG Levels Neither Forecast nor Mark a Lupus Nephritis Flare" .


Effect of Erythropoiesis on circulating levels of erythrocyte complement receptors

CR1 Isoforms Expressed in Primates

Immune Complex Receptor Polymorphisms in SLE and SLE Nephritis

The physiology of immune adherence

The Ohio SLE Study

The Complement System

Is FcgRIIIa pro- or anti-inflammatory? Deciphering its true role in human immune complex disease

A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians

Update on CR1 and SLE

Primate immune adherence receptors

Genetic variation of immune complex receptors: Does it play a role in immune complex disease

The Ohio SLE Study

CR1L, a new member of the Regulators of Complement Activation (RCA) gene cluster

Where there's smoke...Pursuing a novel complement receptor

The role of complement in health and disease

Genetic and Clinical Risk Factors for Human SLE Nephritis

Erythrocyte CR1 consumption is associated with protection against SLE renal flare

Erythrocyte CR1 consumption is associated with protection against SLE renal flare

The role of complement in health and disease

Understanding the role of anti-C1q autoantibodies in lupus nephritis flare: Crossed up by cross-sectional studies

The Ohio SLE Study: A study of the pathogenesis of SLE renal flare

The Ohio SLE Study, form bench to bedside and back again

The Ohio SLE Study: Characterizing renal flare in patients with systemic lupus erythematosus (SLE)

Deciphering the complex role of the complement system in the pathogenesis and prediction of lupus nephritis flare

Complement activation and regulation: How this balance influences SLE nephritic flare

Is a declining vitamin D level a risk factor for SLE flare?

Identifying biomarkers of Lupus Nephritis (LN) Flare: The role of anti-C1q (and others)


Professional Activities

2008 - present NIH PBKD Study Section.