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Inherited Risk of Lung Cancer? Researchers Launch INHERIT EGFR Registry To Investigate

Smoking, most people have come to accept, is a major cause of lung cancer. But each year in the US, up to 24,000 men and women who have never smoked still end up dying from the disease. Researchers led by Geoffrey Oxnard of the Dana-Farber/Brigham and Women's Cancer Center have a hypothesis that for some never smokers who get lung cancer, an underlying, inherited genetic mutation called T790M significantly increases their chances of getting the disease. Now, in an effort to gain a clearer picture of why some carriers of this mutation develop lung cancer, Oxnard and his colleagues have devised a strategy for finding people and their families with this very rare mutation and following them through a registry called INHERIT EGFR. Ohio State University Comprehensive Cancer Center lung cancer specialist Dr. David Carbone is quoted.