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Ramiro Garzon, MD


Staff photo

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-2518

Email: garzon.2@osu.edu

 

Current OSU Appointments

Associate Professor, Hematology

Physician, FGP-Hematology

 

Advising Narrative

Catherine Heaphy (Former research assistant in my lab): 3 peer review manuscripts (one as first co-author in Blood), 2 reviews and several abstracts at international meetings. Currently in Univ of Indiana nursing school.

Nicole Stauffer (Former research assistant in my lab): 2 peer review manuscripts, several abstracts at international meetings ( 1 abstract as first name and presenter at ASH (oral presentation. Currently at Boston University, Phd immunology .

Caroline NA (Former research assistant in my lab): 2 peer review manuscripts, several abstracts at international meetings. Currently at Robert Wood Johnson New Jersey University, medical school, MD program.)

Postdoctoral / Researcher Advising

Parvathi Ranganathan (current post doc in my lab): Pelotonia fellowship award, 2 first author papers (1 plenary paper in Blood), 1 book chapter, currently working on training grant submission (all achievements since 09/2010).

Xueyan Yu (current post doc in my lab, since 2011): 1 first name paper in Blood, working on 2 high profile projects.

Sukhinder Sandhu (post doc in Croce lab and co-mentored with Dr. Croce): 1 paper under second revision at PNAS, 3 reviews.

Violaine Havelange ( MD and former phD student in my lab): (2 first name papers (Blood and Cancer), ASH Travel award , 3 reviews and a Discovery grant award from the Belgium government)

Academic Advising

Graduate professional ( young faculty): Dr. Efebera; Major accomplishments: CTSA award, R21 submitted as multiple PI (SCORED 13 Impact/priority score NHI ( from 10-90) waiting for NOA), 1 clinical trial undergoing and accruing well, currently working on a K23 and an R01 submission.

PhD level: currently supervising and advising 3 people (Ranganathan, Yu and Sandhu).

Undergraduate level: 1research assistant (Jessica Hofsteter). I also often have students during summer rotations in my laboratory and provide career advice.

Biographical

Ramiro Garzon is an assistant professor of medicine in the division of Hematology, Department of Internal Medicine and a member of the Molecular Biology and Cancer Genetics program at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA. He received his M.D. from the National University School of Medicine, Cordoba, Argentina. He trained in hematology and oncology at Thomas Jefferson University, Philadelphia, Pennsylvania, USA, and carried out a fellowship in leukemia at The Ohio State University. His research focuses on microRNA (miRNA) expression and function in normal hematopoiesis and leukemia. In particular, he is interested in dissecting the role of miRNAs in aberrant epigenetics and in developing novel miRNA-based therapies. He has made several original contributions in the field of miRNAs and leukemia, including the first evidence that miRNAs target the DNA methylation machinery. In 2008, he received the prestigious Kimmel Translational Award to help develop miRNA-based therapeutics to target aberrant epigenetics in acute myeloid leukemia (AML). More recently he received an R21 and R01 from the NIH. Dr. Garzon was initially appointed as instructor of Medicine in September of 2006 and was promoted to Assistant Professor of Medicine (tenure track) in April of 2007.

Master/Graduate Advising

I participated in 2 thesis dissertations defense as committee member: Dr Tiziana Palumbo (Universidad de Catania, Italy 5/2009 and Dr. Violaine Havelange (University of Louvain, Brussels, Belgium in 5/2012).My participation in undergraduate research is described in detailed below.

Civic Engagement

I provided hematology clinic services to the OHIO correctional facilities from 2007 to 2010.

Noteworthy Graduate Narrative

Sukhinder Sandhu (PhD student): 3 oral presentations about her work under my co-supervision in Annual meetings of the American Association for cancer research (AACR,Washington 2010), American society of Hematology (ASH, Orlando 2010 and the European Hematology association (EHA, Barcelona 2010), published 2 reviews and obtained a travel award to attend ASH meeting.

Marina Vasquez (PhD student): 1 poster presentation at ASH annual meeting in San Diego, 2011.

Tiziana Palumbo (PhD student): 1 poster presentation AACR, Washington 2006, 5 per review original papers as co-author. Currently at Harvard University as post -doc.

Partnership Narrative

During the course of my career here at OSU I have developed collaborations within and outside the university that in my view as been very positive for the university.

First, I have helped to establish the OSU miRNA therapeutics group (Drs. Byrd, Chan, Liu, Muthusamy, Lee, Croce, Garzon and Marcucci) that hold meetings in a weekly basis. This group have achieved several milestones like the development of an ELISA based assay for miRNA detection, in vivo animal miRNA therapeutics trials and miRNA nanoparticle delivery systems. A total of 3 R01, 1 RC2 and Ohio grants were awarded from data generated by the group and are supporting his research. Several manuscripts has been published, discoveries made, patents filled (2). A PO1 is now to be submitted.

Second I contacted and developed a relationship with Santaris Pharma, the only pharmaceutical company in the world which has clinical trials using miRNAs therapies in humans. the goal is to develop miRNA therapies for acute leukemia. I have coordinated MTA process, collaborative process,, patent solving conflicts, and co develop with Tim Wright a drug development plan and lead discussions of partnership for miRNA therapy development.

Third, I have established research collaborations with outside researchers such as Drs. Blazar (univ of Minnesota )and Weiss (UPENN) that have resulted in publications and grant applications. More importantly b doing so i have brought to the institution expertise in an area that is currently lacking (GVHD and normal hematopoiesis biology).

Academic Advising

2010 - present Parvathi Rangananthan, The Ohio State University. Graduated 2010.
2013 Nina Zitzer, The Ohio State University. Graduated 0.
2016 Betina McNeil, The Ohio State University. Graduated 2011.
2006 - 2008 Tiziana Palumbo, University of Catania. Graduated 2009. MicroRNA gene expression during ATRA differentiation of human APL
2006 - 2008 Tiziana Palumbo, University of Catania. Graduated 0.
2008 - 2009 Andrew Lee, The Ohio State University.
2009 Coleen Valencia, University of Notre Dame. Graduated 0.
2008 - 2010 Nicole Stauffer, The Ohio State University. Graduated 0.
2007 - 2011 Catherine E., The Ohio State University.
2009 - 2011 Sukhinder Sandhu, The Ohio State University. Graduated 2011. Role of miR-155 in B cell malignancies
2009 - 2011 Eugene KOh, The Ohio State University. Graduated 2011.
2009 - 2011 Marina Lipkin, The Ohio State University. Graduated 2011.
2010 - 2011 Jason Mendler, The Ohio State University. Graduated 0.
2007 - 2012 Violaine Havelange, Université Catholique de Louvain. Graduated 0. MicroRNAs: new actors in AML
2007 - 2012 Violaine Havelange, Université Catholique de Louvain. Graduated 2012.
2010 - 2012 Caroline Na, The Ohio State University. Graduated 0.
2011 - 2015 Xueyan Yu, The Ohio State University. Graduated 2005.
 

Clinical Trials

Decitabine With or Without Bortezomib in Treating Older Patients With Acute Myeloid Leukemia

 

Editorial Activities

2008 BMC cancer
2008 - 2012 MCB
2008 - 2012 Blood
2009 - present Journal of Nucleic Acid Investigation (JNAI)
2009 Journal of experimental and clinic research
2009 BMC genomics
2010 Seminars in Oncology
2010 Journal of Cellular and Molecular Medicine
2010 - 2011 Stem Cells and Development
2010 - 2011 Cancer Research
2010 - 2012 Leukemia Research
2010 - 2012 Leukemia
2010 - 2012 Clinical Cancer research
2010 - 2012 British journal of cancer
2010 - 2012 PLOS one
2010 - 2012 Molecular Cancer therapeutics
2010 - 2012 Heamatologica
2010 - 2012 Oncogene
2011 British Journal of Hematology
2011 Leukemia and Lymphoma
2011 Cell death and differentiation
2011 - 2012 EMBO
2012 - present PLOS ONE
2012 - present Datasets Papers in Imunology
 

Honors

2007 - 2008 Lauri Strauss Discovery award. Lauri Strauss Foundation.
2008 - 2009 Second highest patient satisfaction score in the OSU medical center (2008-2009). The Ohio State University.
2008 - 2010 Kimmel Translational Award. Kimmel Foundation for Cancer Research.
2009 - 2011 Leukemia SPORE Career Development award. NIH (NCI).
2010 - 2011 CAPS preceptorship recognition for dedicated service in the college of Medicine Educational Programs. College of Medicine.
2011 - present Thompson Reuters KOL expert. Thompson Reuters.
2011 Molecular Biology and Cancer Genetics Program, Member. Molecular Biology and Cancer Genetics.
2013 - present Member of the Molecular,Celullar and Developmental Biology. The Ohio State University.
2014 - present Member of the Graduate Program in Comparative and Veterinary Medicine. Veterinary School.
2015 - present Leukemia and Lymphoma Society Scholar Award. Leukemia and Lymphoma society.
 

Professional Activities

2008 - present Consultancy. Reckner mednet.
2009 - present CTSA reviewer. OSU CTSA Pilot Award program. Columbus, OH.
2011 - present ACS OSU Institutional seed grants. American Cancer Society. Columbus, OH.
2011 - present Dr. Yvonne Efebera. OSU-Division of Hematology. Columbus, OH.
2012 - present Grant Reviewer. Association for Internatioal Cancer Research.
2012 - present Grant Reviewer. Cancer Research UK.
2009 Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Austria, Vienna. Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Austria, Vienna.
2009 Proposal reviewer. Hong Kong Research Grants Council.
2010 NHLSRT Development Grant. Medical Research Council of South Africa.
2010 Israeli Science Foundation Grant reviewer. Israeli Science Foundation.
2010 Scientific advisory board. Martell Foundation. Boston, MA.
2011 Grant Reviewer. Italian Association for Cancer Research.
2011 Cariplo Foundation.
2010 - 2012 Proposal review. Bernische Krebsliga.
2010 - 2012 Dutch Cancer Society. Dutch Cancer Society.
2010 - 2012 Grant review. Fondazione Cariplo.
2011 - 2012 Department of Defense (DOD) Discovery awards Blood cancer study section. Department of Defense.
2012 Grant Reviewer. Medical Research Council.
2012 Grant Reviewer. Eropean Research Council.