320 W 10th Ave
Columbus, OH 43210
Phone: (614) 293-2887
Associate Professor-Clinical, Pathology
Representative to the Department of Medicine for Faculty Mentorship Group.
With the assistance of my collaborator in the Department of Pathology, Dr. Haifeng Wu, we have established and expanded The Ohio State University Thrombotic Thrombocytopenic Purpura (TTP) Research Program dramatically over the past year. Since initiating this research program now 10 years ago, we have enrolled over 80 patients and banked over 3,000 plasma samples for present and future study, not an insignificant accomplishment for such rare disease. Our work has resulted in the publication of over 40 peer-reviewed articles in peer-reviewed journals as well as several abstracts that have been presented in both oral and poster forms at international meetings in the field. We have also patented a novel methodology to measure a laboratory biomarker in TTP and have established Dr. Haifeng Wu’s research lab as a CAP certified, national reference lab for the clinical evaluation of ADAMTS13 biomarkers.
We have completed 2 prospective therapeutic trials evaluating the use of adjuvant immune-suppressive therapy as an adjunct to plasma exchange. These studies have led to a multi-center, prospective randomized trial of corticosteroids or cyclosporine as an adjunct to plasma exchange which we as the lead institution and have opened and have begun accruing patients. This study is presently ongoing and being supported by an R01 from the FDA for which I am the co-principal investigator
Based on the accomplishments of our research program, we previously entered into an agreement with the Archemix Corporation to conduct an observational and retrospective study in TTP, the goal of which is to eventually proceed with a multinational, randomized study of a novel therapy for TTP. I was appointed to the steering committee of this international study and that was closed prematurely, but the initial results of the study were published with myself as the lead author.
Based upon my involvement and leadership in the previously mentioned study, I was asked to be the North American Study Coordinator and consultant to Ablynx for a multicenter, international therapeutic TTP study similarly using an A1 domain targeting therapy. This clinical trial studying a truly novel TTP therapy is presently accruing patients internationally with Ohio State being the lead North American site. I also serve as a consultant for the ongoing management of this study and eventually the analysis and publication of the data when the study is complete.
An additional focus of our work in the Ohio State TTP Research program has centered around study novel laboratory biomarker data to objectively and accurately differentiate TTP from other forms of thrombotic microangiopathies that require a different and unique form of therapy. We have developed a panel of ADAMTS13 and complement activation biomarkers that are being studied regarding their ability to differentiate these disorders as well as predict clinical outcome. We recently received a $200,000 research grant from Alexion to further expand these research efforts in patients with aHUS. Additionally, we just received a $200,000 research grant from the Answering TTP Foundation to expand our efforts to study the role of complement activation in patients acutely presenting with the diagnosis of TTP and throughout long term follow-up.
We expect both the number of publications and the significance of these publications and the influence of our work to continue to increase in the coming years. Our research program is unique in its laboratory and clinical expertise that allows us to conduct basic science and mechanistic studies, but also to enable us to lead international TTP and aHUS studies given our expertise and expansive cohort of patients followed. Increases in research funding more recently will provide the resources required to continue to expand the impact of the Ohio State TTP Research Program. Additional grant proposals supporting our studies of complement activation in patients with thrombotic microangiopathies (TTP and aHUS) have been submitted and favorably scored which will help support the continued growth of our program.
Since joining the faculty in of Ohio State University I have been active in the teaching of medical students, residents, and fellows. I was involved in curriculum development having designed and helped to implement the Hematologic Pathophysiology Independent Study module for the second year Independent Study Program. In addition, I have been a regular lecturer in the college of medicine for both students in the second year of medical school as well as third year students as they go through their internal medicine rotations. I am also very active in the mentoring and clinical teaching of medical students, residents and fellows on in the patient benign hematology consult service as well as in my outpatient clinic. I received the Bertha Bourncle Teaching Award in 2007 which is given recognize the teacher of the year in the Division of Hematology. The reviews and evaluations received from students, fellows, and from peers/audience members from the numerous lectures, invited presentations, and CME presentations I believe support the effectiveness of my teaching skills.
Despite my active research responsibilities, I have maintained an active clinical practice where I see outpatients with benign hematologic diseases 2 days per week. In addition I continue to attend on the inpatient hematology consult service 4 months each year. Administratively, I am an active member of several important committees at the university and the hospital as detailed in my dossier below. I also serve as the director of mentorship for the Division of Hematology and am the mentorship representative to the Department of Medicine from the Division of Hematology. I also have been a member of the Biomedical Sciences Institutional Review Board for the past year and have recently joined the Promotion and Tenure Committee for the Department of Internal Medicine.
|2000 - present||Medical License - 35-06-9289-C: State Medical Board of Ohio|
|2010 - present||Board Certification: American Board of Hematology|
|1997 - 2007||Board Certification: American Board of Internal Medicine|
|2000 - 2010||Board Certification: American Board of Internal Medicine|
|2000 - 2010||Board Certification: American Board of Internal Medicine|
[Treatment of adult acute lymphoblastic leukemia]
Excessive Bleeding with Normal Prothrombin Time, Partial Thromboplastin Time and Platelet Count.
|12/01/2006||Hematology Consultation Service (James Cancer Hospital, Internal Medicine, Hematology/Oncology)|
|10/01/2009||Associate Professor of Clinical Medicine (2nd floor James Cancer Hospital, Hematology)|
|09/01/2012||Associate Professor of Clinical Medicine (James Care East)|
|07/01/2014||Hematology Out-Patient Clinic (2nd Floor James Cancer Hospital Clinic)|
|07/01/2014||In-Patient Hematology Consulatation Service (James Cancer Hospital)|
|07/01/2014||Hematology Out-Patient Clinic (JamesCare East)|
|01/01/2001 - 09/01/2009||Assistant Professor of Clinical Medicine (2nd floor of the James Cancer Hospital, Hematology/Oncology)|
Improved clinical outcome and ADAMTS13 activity following cyclosporine therapy in patients with TTP.
Cyclosporine and plasma exchange is superior to corticosteroids and plasma exchange as initial therapy of TTP
Cyclosporine alone for the treatment of early recurrences of TTP
Low ADAMTS13 activity in clinical remission predicts the risk of TTP relapses
Cyclosporine is effective prophylactic therapy in preventing recurrences of TTP
ADAMTS13 antigen levels and the risk of relapse during long-term clinical follow up of patients with idiopathic thrombotic thrombocytopenic purpura.
Clinical utility of ADAMTS13 biomarkers in the evaluation of TTP
A Randomized, Double-Blind, Placebo-Controlled, Clinical Outcome Study of ARC1779 In Patients with Thrombotic Thrombocytopenic Purpura (TTP)
Phase I Trial of Flavopiridol In Relapsed Myeloma: Brief Response In t(4;14) with Significant Neutropenia
|1990||B.S., The Ohio State University|
|1994||M.D., The Ohio State University|
|2004 - present||British Journal of Haematology|
|2004 - present||Blood|
|2005 - present||Thrombosis and Hemostasis|
|2005 - present||American Journal of Hematology|
|2008 - present||Nature Clinical Practice Cardiovascular|
|2008 - present||Nature Cardiovascular Medicine|
|1990 - 1991||Summa Cum Laude.|
|1990 - 1991||College of Business Pacesetter Award.|
|1992 - 1993||Cancer Research Assistant Program Grant.|
|1999 - 1998||Amgen Fellow.|
|1999 - 2000||Kaminer Award.|
|2007||Bertha Bouroncle Distinguished Faculty Teaching Award. Division of Hematolgoy/Oncology.|
"Venous thromboembolic disease. NCCN. Clinical practice guidelines in oncology.." Journal of the National Comprehensive Cancer Network : JNCCN. Vol. 6, no. 8. (September 2008.): -.
"Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura." HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. Vol. 95, no. 9. (September 2010.): -.
"Capped-dose mitomycin C: a pooled safety analysis from three prospective clinical trials." CANCER CHEMOTHERAPY AND PHARMACOLOGY. Vol. 65, no. 2. (January 2010.): -.
|January 1998||Cataland SR, Clementi B, Daugherty, CK, Larson RA.."Preliminary experience with a novel of post-remission chemotherapy regimen for adults with acute lymphoblastic leukemia." . : 255a|
|January 1998||Cataland SR, Kuzel T, Vogelzang NJ, Stadler WM.."A Phase II Trial of Radiation (RT) and Outpatient Subcutaneous IL-2 Plus GM-CSF in Patients with Metastatic Renal Cell Cancer." . : 1262|
|January 1999||Cataland SR, Weseman E, Daugherty CK, Larson RA."Preliminary experience with a new chemotherapy regimen for adults with acute lymphoblastic leukemia." . : 296a|
|January 1999||Cataland SR, Thirman MJ."Molecular and clinical analysis of MLL-ELL translocations inpatients with acute leukemia." . : 498a|
|January 2004||Cataland SR, George JN, Kraut EH, Bourgeois TT, Ferketich AK, Kennedy MS, Caligiuri MA, Wu HM.."Improved Clinical Outcome and ADAMTS13 Activity Following Cyclosporine Therapy in Patients with TTP" . : 243a|
|November 2004||William Blum, Kristie A. Blum, Cheryl Kefauver, Mollie Moran, Kenneth Chan, John C. Byrd, Spero Cataland, Michael R. Grever, Guido Marcucci."Decitabine-Induced Differentiation Syndrome in a Patient with Acute Myeloid Leukemia: A Case Report." .|
|November 2005||Eric H. Kraut, Spero R. Cataland, Leslie Witkoff, Sylvia Jordan, William T. Gunning."Evaluation of Qualitative Platelet Disorders in Patients with Hemophilia" .|
|November 2005||Spero R. Cataland, Ming Jin, Amy K. Ferketich, Eric H. Kraut, James N. George, Haifeng M. Wu.."Cyclosporine and Plasma Exchange is Superior to Corticosteroids and Plasma Exchange as Initial Therapy of TTP" .|
|November 2005||Kurt P. Leuenberger, Spero Cataland, Ming Jin, Carol Orr, Guido Marcucci, Eric H. Kraut, Haifeng Wu."Distinguishing Antiphospholipid Antibodies from an Acquired Factor Inhibitor: A Novel Laboratory Approach." .|
|November 2005||Guido Marcucci, W. Stock, J.A. Zwiebel, S.R. Cataland, G. Dai, M. Moran, D. Lucas, S. Liu, M.I. Klisovic, C. Kefauver, M. Green, K. K. Chan, S. R. Frankel, M.R. Grever, J.C. Byrd."Clinical Activity of Genasense (GNS, Oblimersen Sodium), a Pro-Apoptotic to Bcl-2 Oligonucleotide, in combination with Daunorubicin and Cytarbine: A Phase I Study in Previously Untreated Elderly Acute Myeloid Leukemia (AML)." .|
|November 2005||Spero R. Cataland, Min Jin, Amy K. Ferketich, X. Long Zheng, James N. George, Haifeng M. Wu.."Cyclosporine Alone for the Treatment of Early Recurrences of TTP." .|
|November 2005||Subha V. Raman, Orlando P. Simonetti, Spero R. Cataland, William J. Hicks, Eric H. Kraut."Myocardial Ischemia without Coronary Artery Obstruction in Patients with Sickle Cell Disease." .|
|November 2005||Haifeng Wu, Spero Cataland, Michael Bissell, Ming Jin.."A Rapid Test for the Diagnosis of Thrombotic Thrombocytopenic Purpura Using SELDI-TOF-Mass Spectrometry." .|
|November 2005||Wendy Stock, Daohal Yu, Ben Sanford, Gerard Lozanski, Spero Cataland, Ravi Vij, John Byrd, Bayard Powell, Meir Wetzler, Maher Albitar, Dorie Sher, Colin Edwards, Eva Hoke, Clara D. Bloomfield, Richard A. Larson."Incorporation of Alemtuzumab into Front-Line Therapy of Adult Acute Lymphoblastic Leukemia (ALL) is Feasible: A Phase I/II Study from the Cancer and Leukemia Group B (CALGB 10102)" .|
|November 2006||Spero R. Cataland, Eric H. Kraut, Don Benson, Amy K. Ferketich, April Horne, Ming Jin, James N. George, Haifeng M. Wu.."Improved Clinical Outcome and ADAMTS13 Activity after Concurrent Cyclosporine and Plasma Exchange in TTP" .|
|January 2007||Cataland SR, Jin, M, Lin S, Kennedy MS, Kraut EH, George JN, and Wu HM.."ADAMTS13 Antigen Levels and the Risk of Relapse During Long-Term Follow-Up of Patients with Idiopathic Thrombotic Thrombocytopenic Purpura." . : 3204a|
|April 2008||Klisovic RB, Stock W, Cataland S, Klisovic MI, Liu S, Blum W, Green M, Odenike O, Godley L, Burgt JV, Van laar E, Cullen M, Macleod AR, Besterman JM, Reid GK, Byrd JC, Marcucci G.."A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia." . : 2444-9|
|May 2008||Jin M, Casper TC, Cataland SR, Kennedy MS, Lin S, Li YJ, Wu HM.."Relationship between ADAMTS 13 activity in clinical remission and the risk of TTP relapse." . : 8|
|March 2011||Eric H. Kraut."." .|
|October 2011||Dr. Eric Kraut."." .|
A diagnosis test for Thrombotic Thrombocytopenia Purpura using SEDLI-TOF Spectrometer.
Advances in Thrombotic Thrombcytopenic Purpura
Hematologic Disorders of Pregnancy
Doctor, Why Am I Bruising So Easily?
Immune Based Therapy of TTP
Prospective Studies with Long-Term Follow-Up of Corticosteroids and Cyclosporine Given Individually as Adjuncts to Plasma Exchange in the Initial Treatment of TTP
Differentiating the Thrombotic Microaniopathies: The Role of ADAMTS13 Activity Testing in TTP
Venous Thromboembolid Disease and Hypercoagulable Disorders
Randomized Study of Cyclosporine or Corticostero8ids and Plasma Exhcnage as the Initial Therapy of Thrombotic Thrombocytopenic Purpura
Nplate for Chronic Immune Thrombocytopenic Purpura
ADAMTS13 Activity, Race, and Age as Predictors of Exacerbation in Patients with Idiopathic Thrombotic Thrombocytopenic Purpura (TTP)
Objective Documentation of Neurologic Injury in Patients with Idiopathic Thrombotic Thrombocytopenia Pupura (TTP)
(ITP) Idiopathic Thrombotic Purpura
Genetic Testing in Venous Thromboembolic Disease: Does it Really Matter Clinically?
aHUS and (TTP) Thrombotic Thrombocytopenic Purpura
Advances in Diagnosis and Treatment of aHUS
Diagnosis and Management of Microangiopathic Hemolytic Anemias.
Changing Perspectives on TTP and Atypical HUS
Challenges in Differentiating the Thrombotic Microangiopathies. TTP and aHUS Symposium.
Evolving Understanding of Atypical Hemolytic Uremic Syndrome.
Treatment options for TTP and atypical HUS in the 21st century.
Complement Medicated Thrombotic Microangiopathies
Advances in the Management of Complement-Mediated Thrombotic Microangiopathies.
|2006 - present||Panel Expert for Net Wellness, Consumer Health Information. Net Wellness, Consumer Health Information. Columbus, OH.|
|2008 - present||National Study Coordinator for Archemix 006 Clinical Trial. Archemix.|
|2008 - present||Invited Member of International Steering Committee. Archemix.|
|2009 - present||Thrombotic Thromboctytopenic Purpura (TTP) Patient Support Group Meeting.|
|2010 - present||Expert to the Answering Thrombotic Thrombocytopeni Purpura (TTP) Foundation.|
|2010 - present||Atypical Hemolytic Uremic Syndrome International Advisory Board Meeting. Alexion Pharmaceuticals. Orlando, FL.|