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Somashekar Krishna, MD, MPH


Somashekar Krishna, MD, MPH

Clinical Interests
Advanced Therapeutic Endoscopy

Research Interests
Solid and cystic pancreatic lesions, advanced imaging techniques (confocal endomicroscopy), endoluminal stent

Present Position
Assistant Professor
Sections of Advanced Endoscopy and Pancreatic Diseases
Division of Gastroenterology, Hepatology and Nutrition
The Ohio State University Wexner Medical Center

Education
Bachelor of Medicine & Bachelor of Surgery (MBBS), Bangalore Medical College, India
Master of Public Health (MPH), University of Alabama at Birmingham, Alabama
Residency in Internal Medicine, University of Arkansas for Medical Sciences
Fellowship in Gastroenterology and Hepatology, University of Arkansas for Medical Sciences  
Fellowship in Advanced Therapeutic Endoscopy, The University of Texas MD Anderson Cancer Center, Houston, Texas

Board Certifications
2004 Board Certified in Internal Medicine
2012 Board Certified in Gastroenterology and Hepatology

Honors and Awards
2016 The American College of Gastroenterology Presendial Plenary Presentation
2016 The American College of Gastroenterology Award for Research in Category of Biliiary and Pancreatic Disease
2016 ASGE/Gastrointestinal Endoscopy, Best Reviewer Award
2016 Digestive Disease Week, Poster of Distinction
2015 The Michael Grever Annual award for research in Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center
2015 Research award from American College of Gastroenterology Institute for Clinical Research & Education
2014 The American College of Gastroenterology Obesity Award for Research
2014 Young Investigator Travel Award, The American Pancreatic Association & Japan Pancreas Society
2012 Top 10th decile, ABIM board examination in Gastroenterology and Hepatology
2009 American College of Gastroenterology/AstraZeneca Senior Fellow Award
2009 Fellowship2Leadership fellow educational award
2003 Best Primary Care Resident, John L. McClellan Veteran’s Hospital, Arkansas

Membership
2013 American Pancreatic Association
2008 American Gastroenterological Association
2008 American College of Gastroenterology
2008 American Society for Gastrointestinal Endoscopy
2004 American Board of Internal Medicine
 
Publications (selected)

Book Chapter

1. Pidlaoan V, Krishna SG. Chapter 13: Management of Medical Complications of Gallstone Disease. Book: Multidisciplinary Management of Common Bile Duct Stones. 1st Edition, 2016, Springer International Publishing.

Peer reviewed “original clinical research”

  1. Krishna SG, Behzadi J, Hinton A, El-Dika S, Groce JR, Hussan H, Hart PA, Conwell DL. Effects of Bariatric Surgery on Outcomes of Patients With Acute Pancreatitis. Clin Gastroenterol Hepatol. 2016 Feb 20. pii: S1542-3565(16)00163-4. PMID: 26905906.
  2. Zhang C, Krishna SG, Hinton A, Arsenescu R, Levine EJ, Conwell DL. Cytomegalovirus-Related Hospitalization Is Associated With Adverse Outcomes and Increased Health-Care Resource Utilization in Inflammatory Bowel Disease. Clin Transl Gastroenterol. 2016 Mar 10;7:e150. PMID: 26963000.
  3. Shirley LA, Walker J, Krishna SG, El-Dika S, Muscarella P, Ellison EC, Schmidt CR, Bloomston M. Routine Cyst Fluid Cytology Is Not Indicated in the Evaluation of Pancreatic Cystic Lesions. J Gastrointest Surg. 2016 May 26. [Epub ahead of print] PubMed PMID: 27230996.
  4. Krishna SG, Hinton A, Oza V, Hart PA, Swei E, El-Dika S, Stanich PP, Hussan H, Zhang C, Conwell DL. Morbid Obesity Is Associated With Adverse Clinical Outcomes in Acute Pancreatitis: A Propensity-Matched Study. Am J Gastroenterol. 2015 Nov;110(11):1608-19. PMID: 26482857
  5. Hussan H, Gray DM 2nd, Hinton A, Krishna SG, Conwell DL, Stanich PP. Morbid Obesity is Associated with Increased Mortality, Surgical Complications, and Incremental Health Care Utilization in the Peri-Operative Period of Colorectal Cancer Surgery. World J Surg. 2015 Dec 7. PMID: 26643515
  6. Cronley K, Wenzke J, Hussan H, Vasquez AM, Hinton A, El-Dika S, Conwell DL, Krishna SG, Stanich PP. Diverticulitis in HIV-infected patients within the United States. HIV Med. 2015 Aug 18. PMID: 26283564.
  7. Krishna SG, Bektas M, Ross WA, Weston B, Katz MH, Fleming JB, Lee JH, Bhutani MS. Prevalence of extra-pancreatic cysts in patients with cystic pancreatic lesions detected by endoscopic ultrasound. Endosc Ultrasound. 2015 Jul-Sep;4(3):219-24. PMID: 26374580.
  8. Behzadi J, Oza VM, Porter K, Moore SA, Stanich PP, Conwell DL, Krishna SG, Walker JP, El-Dika S. Proximal Serrated Polyp Detection Rate Correlates with Adenoma Detection Rate and is Impacted by Mean Withdrawal Time: A Retrospective Study. Journal of Gastrointestinal & Digestive System (Accepted Dec 2015)
  9. Krishna SG, Bhattacharya A, Feng Li, Ross WA, Ladha H, Porter K, Atiq SM, Bhutani MS, Lee JH. Diagnostic differentiation of pancreatic neuroendocrine tumor from other neoplastic solid pancreatic lesions during endoscopic ultrasound guided fine needle aspiration. Pancreas. 2015 Sep 24. PMID: 26418912.
  10. Krishna SG, Bhattacharya A, Ross WA, Ladha H, Porter K, Bhutani MS, Lee JH. Pretest prediction and diagnosis of metastatic lesions to the pancreas by endoscopic ultrasound-guided fine needle aspiration. J Gastroenterol Hepatol. Oct;30(10):1552-60. PMID: 25867963.
  11. Oza V, Skeans JM, Muscarella P, Walker J, Sklaw BC, Cronley KM, El-Dika S, Swanson B, Hinton A, Conwell DL, Krishna SG. Groove Pancreatitis, a masquerading yet distinct clinicopathological entity: Analysis of Risk Factors and Differentiation. Pancreas. Apr 18. [Epub ahead of print] PMID: 25899649.
  12. Krishna SG, Li F, Bhattacharya A, Ladha H, Porter K, Singh A, Ross WA, Bhutani MS, Lee JH.  Differentiation of pancreatic ductal adenocarcinoma from other neoplastic solid pancreatic lesions: A tertiary oncology center experience. Gastrointestinal Endoscopy. Feb;81(2):370-9. Epub 2014 Oct 24. PMID: 25442085.
  13. Krishna SG, Rao BB, Thirumurthi S, Lee JH, Ramireddy S, Guindani M, Ross WA. Safety of endoscopic interventions in patients with thrombocytopenia. Gastrointest Endosc. 2014 Apr 8;PMID: 24721520.
  14. Krishna SG, Zhao W, Apewokin SK, Krishna K, Chepyala P, Anaissie EJ. Risk factors, preemptive therapy, and antiperistaltic agents for Clostridium difficile infection in cancer patients. Transpl Infect Dis. 2013 Oct;15(5):493-501. PMID: 24034141.
  15. Lee JH, Krishna SG, Singh A, Ladha HS, Slack RS, Ramireddy S, Raju GS, Davila M, Ross WA. Comparison of the utility of covered metal stents versus uncovered metal stents in the management of malignant biliary strictures in 749 patients. Gastrointest Endosc. 2013 Aug;78(2):312-24. PMID: 23591331.
  16. Wang W, Shpaner A, Krishna SG, Ross WA, Bhutani MS, Tamm EP, Raju GS, Xiao L, Wolff RA, Fleming JB, Lee JH. Use of EUS-FNA in diagnosing pancreatic neoplasm without a definitive mass on CT. Gastrointest Endosc. 2013 Jul;78(1):73-80. PMID: 23523302.
  17. Raju GS, Vadyala V, Slack R, Krishna SG, Ross WA, Lynch PM, Bresalier RS, Hawk E, Stroehlein JR. Adenoma detection in patients undergoing a comprehensive colonoscopy screening. Cancer Med. 2013 Jun;2(3):391-402. PMID: 23930215.
  18. Suzuki R, Lee JH, Krishna SG, Ramireddy S, Qiao W, Weston B, Ross WA, Bhutani MS. Repeat endoscopic ultrasound-guided fine needle aspiration for solid pancreatic lesions at a tertiary referral center will alter the initial inconclusive result. J Gastrointestin Liver Dis. 2013 Jun;22(2):183-7. PMID: 23799217.
  19. Krishna SG, Zhao W, Grazziutti ML, Sanathkumar N, Barlogie B, Anaissie EJ. Incidence and risk factors for lower alimentary tract mucositis after 1529 courses of chemotherapy in a homogenous population of oncology patients: clinical and research implications. Cancer. 2011 Feb 1;117(3):648-55. PMID: 20862749.
  20. Talamo G, Cavallo F, Zangari M, Barlogie B, Lee CK, Pineda-Roman M, Kiwan E, Krishna SG, Tricot G. Hyperammonemia and encephalopathy in patients with multiple myeloma. Am J Hematol. 2007 May;82(5):414-5. PMID: 17133420.
  21. Shaughnessy JD Jr, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, Stewart JP, Kordsmeier B, Randolph C, Williams DR, Xiao Y, Xu H, Epstein J, Anaissie E, Krishna SG, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G, van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood. 2007 Mar 15;109(6):2276-84. PMID: 17105813.
  22. Pineda-Roman M, Bolejack V, Arzoumanian V, Anaissie E, van Rhee F, Zangari M, Walker R, Hollmig K, Shaughnessy JD Jr, Epstein J, Krishna SG, Crowley J, Barlogie B. Complete response in myeloma extends survival without, but not with history of prior monoclonal gammopathy of undetermined significance or smouldering disease. Br J Haematol. 2007 Feb;136(3):393-9. PMID: 17156398.
  23. Grazziutti ML, Dong L, Miceli MH, Krishna SG, Kiwan E, Syed N, Fassas A, van Rhee F, Klaus H, Barlogie B, Anaissie EJ. Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: incidence, risk factors and a severity predictive model. Bone Marrow Transplant. 2006 Oct;38(7):501-6. PMID: 16980998.
  24. Talamo G, Cavallo F, Zangari M, Barlogie B, Lee CK, Pineda-Roman M, Kiwan E, Krishna SG, Tricot G. Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica. 2006 Jul;91(7):964-7. PMID: 16818286.
  25. Barlogie B, Tricot G, Anaissie E, Shaughnessy J, Rasmussen E, van Rhee F, Fassas A, Zangari M, Hollmig K, Pineda-Roman M, Lee C, Talamo G, Thertulien R, Kiwan E, Krishna SG, Fox M, Crowley J. Thalidomide and hematopoietic-cell transplantation for multiple myeloma. N Engl J Med. 2006 Mar 9;354(10):1021-30. PMID: 16525139.
  26. Grazziutti ML, Dong L, Miceli MH, Cottler-Fox M, Krishna SG, Fassas A, van Rhee F, Barlogie BM, Anaissie EJ. Recovery from neutropenia can be predicted by the immature reticulocyte fraction several days before neutrophil recovery in autologous stem cell transplant recipients. Bone Marrow Transplant. 2006 Feb;37(4):403-9. PMID: 16400338.

Peer reviewed “review articles”

  1. Krishna SG, Lee JH. Appraisal of needle-based confocal laser endomicroscopy in the diagnosis of pancreatic cysts. World J Gastroenterol 2016 January 7; 22(1), accepted.
  2. Atiq M, Suzuki R, Khan AS, Krishna SG, Ridgway TM, Guha S, Hernandez LV, Nealon WH, Lee JH, Bhutani MS. Clinical decision making in the management of pancreatic cystic neoplasms. Expert Rev Gastroenterol Hepatol. 2013 May;7(4):353-60. PMID: 23639093.
  3. Krishna SG, Lee JH. Endosonography in solid and cystic pancreatic tumors. J Interv Gastroenterol. 2011 Oct;1(4):193-201. PMID: 22586537.

Peer reviewed “novel endoscopy techniques”

  1. Kamboj AK, Modi RM, Swanson BJ, Conwell DL, Krishna SG. A comprehensive examination of the novel techniques used for in vivo and ex vivo confocal laser endomicroscopy of pancreatic cystic lesions. Gastrointestinal Endoscopy (accepted 2016)
  2. Kamboj AK, Swanson BJ, Dillhoff ME, Conwell DL, Krishna SG. Cystic pancreatic neuroendocrine tumors: correlation of in vivo needle-based confocal endomicroscopy findings by ex vivo analysis.Video Gastrointestinal Endoscopy (accepted 2016)
  3. Modi RM, Swanson B, Muscarella P 2nd, Conwell DL, Krishna SG. Novel techniques for diagnosis of serous cystadenoma: fern pattern of vascularity confirmed by in vivo and ex vivo confocal laser endomicroscopy. Gastrointest Endosc. 2016 Jul 19. PubMed PMID: 27449195.
  4. Krishna SG, Shakhatreh M. Endoscopic removal of over-the-scope clip with cold saline solution technique. Gastrointest Endosc. 2016 May 17. [Epub ahead of print] PubMed PMID: 27207824.
  5. Krishna SG, Swanson B, Conwell DL, Muscarella P 2nd. In vivo and ex vivo needle-based confocal endomicroscopy of intraductal papillary mucinous neoplasm of the pancreas. Gastrointest Endosc. 2015 Sep;82(3):571-2. Epub 2015 May 21. PMID: 26005013.
  6. Rao BB, Oza VM, Swanson B, Krishna SG. Intratumoral Endoscopy and Diagnosis of a Large Gastrointestinal Stromal Tumor. J Gastrointest Cancer. 2014 Mar 18;PMID: 24639237.
  7. Stanich PP, Sklaw B, Krishna SG. Persistent peristomal leakage from percutaneous endoscopic gastrostomy successfully treated with endoscopic suturing. Endoscopy. 2013 Nov;45 Suppl 2 UCTN:E394. PMID: 24285066.
  8. Chen WC, Weston B, Krishna SG, Gomez G, Rashid A, Katz MH, Lee JE, Raju GS. Prolonged endoscopic loop ligation for removal of gastrointestinal tumors. Endoscopy. 2013;45 Suppl 2 UCTN:E69-70. PMID: 23526523.
  9. Heif M, Krishna SG, Beheshti M, Kakati B, Rego R. Percutaneous transhepatic cholangioscopy using a flexible digital ureteroscope through a 10-fr vascular sheath: a novel method to evaluate bile duct injury in patients with Roux-en-Y gastric bypass surgery. Dig Endosc. 2012 May;24(3):189. PMID: 22507096.
  10. Krishna SG, McElreath DP, Rego RF. Direct pancreatoscopy with an ultrathin forward-viewing endoscope in intraductal papillary mucinous neoplasm of the pancreas. Clin Gastroenterol Hepatol. 2009 Dec;7(12):e75-6. PMID: 19683071.

Oral Presentations at Annual Conferences of Major Societies

  1. Krishna SG, Hinton A, Yadav D, Conwell DL. Cholecystectomy During Index Admission for Gallstone Pancreatitis Lowers 30-Day Readmission Rates: Analysis of the Nationwide Readmission Database. American College of Gastroenterology 2016
  2. Krishna SG et al. Needle Based Confocal Laser Endomicroscopy Can Reliably Distinguish Mucinous from Non-mucinous Pancreatic Cystic Lesions: An International External Inter-and Intra-observer Study. American College of Gastroenterology 2016
  3. Swanson B, Conwell DL, Frankel W, Krishna SG. Ex Vivo Confocal Laser Endomicroscopy Is Useful in the Evaluation of Pancreatic Cystic Lesions. United States & Canadian Academy of Pathology’s Annual Meeting, 2016
  4. Krishna SG, Hinton A, Hart PA, Conwell DL. Epidemiology of hospitalized patients with acute pancreatitis: Etiological changes over the last decade. American Pancreatic Association 2015.
  5. Krishna SG, Behzadi J, Hinton A, El-Dika S, Groce JR, Hussan H, Conwell DL. Acute pancreatitis (AP) in post-bariatric surgery (BRS) status: Analysis of national trends, complications and outcomes from 2007 to 2011. American College of Gastroenterology 2014.
  6. Krishna SG, Hinton A, El-Dika S, Groce J, Hussan H, Zhang C, Stanich PP, Li N, Conwell DL. Morbid Obesity (MO) is Associated with Increased Healthcare Utilization and is an Independent Predictor of Mortality of Acute Pancreatitis (AP). American College of Gastroenterology 2014.
  7. Krishna SG, Rao BB, Thirumurthi S, Lee JH, Ramireddy S, Guindani M, Ross WA. Evaluating safety of gastrointestinal endoscopy, mucosal biopsy and polypectomy in patients with thrombocytopenia. Digestive Disease Week 2013.