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Liu, Zhenguo MD


Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-8435

Email: liu.642@osu.edu

 

Current OSU Appointments

Professor, Cardiovascular Medicine

Physician, FGP-Cardiovascular Medicine

 

Biographical

I started my career in cardiovascular medicine in July 2004 after my extensive clinical trainings in internal medicine, cardiovascular diseases, and adult clinical cardiac electrophysiology as a tenure-track assistant professor in the Division of Cardiovascular Diseases and the Davis Heart & Lung Research Institute at The Ohio State University (OSU) Medical Center in Columbus, Ohio. Prior to resuming my clinical training, I completed a master project in pharmacology and toxicology in the Department of Pharmacology at Queen’s University at Kingston, Ontario, Canada in 1992, and a PhD program in cardiovascular pharmacology at the same institute in 1995. Subsequently, I pursued a post-doctoral fellowship in the Whitaker Cardiovascular Institute at Boston University Medical Center from 1995 to 1997 in the area of cell biology and vascular biology.

Over the last 11 years, I have been providing quality care to my patients, educating medical students, residents, fellows, and younger generations of scientists, and established an independent and successful research program on bone marrow stem cells, endothelial cells, and vascular biology and pharmacology. I am proud to say that it has been a successful and satisfactory career for the past 11 years at OSU Medical Center. My major achievements are summarized in the following:

A. Provided high quality care to the patients

I have been spending 50-70% of my effort on clinical activities to take great care of my patients (both in-patients and out-patients) with cardiovascular diseases with favorable outcomes. I currently have 60% of effort on clinical responsibilities.

B. Supervised students (PhD students and medical students), fellows, and visiting scholars

Although I don’t teach regular causes, I have tried my best to teach the medical students, residents, and fellows through extensive interactions on my service, clinic, and procedure almost on daily basis. My teaching has been effective and well received in general with positive evaluations by the students and fellows. I was awarded “Dedicated Service Award in the College of Medicine Educational Program (Ambulatory Care)”, College of Medicine, the Ohio State University Wexner Medical Center 2012-2013.

In addition to supervising medical students, residents, and sub-specialty fellows on my service, clinic, and procedure areas, I have supervised at least 25 trainees in my research lab in the past 10 years.

C. Established an independent research program with continuous NIH and AHA funding for the past 11 years without interruption

I have been directing an independent research laboratory with a focus on bone marrow stem cells (BMSCs) and endothelial cell biology, nitric oxide, and eNOS expression, as well as molecular signaling including ERK1/2, Akt, cGMP, and STAT-3 pathways. My lab has established a reliable in vitro system to differentiate adult BMSCs into functional endothelial cells and cardiomyocytes. One of the major areas of my research program has been focused on investigating the effect of cardiovascular risk factors including hyperlipidemia and DM on BMSCs and their differentiation especially endothelial differentiation and related mechanisms. We are also very active on investigating the mechanisms involved in cardiac differentiation of BMSCs, and cardiac regeneration using BMSCs, as well as the in vivo survival of BMSCs and related mechanisms. Recently, we are actively investigating the role of ox-LDL in the survival of transplanted BMSCs and therapeutic efficacy and related mechanism(s). It has the potential to provide a new mechanism that may be responsible for the poor survival of the transplanted BMSCs, and will have important translational value and clinical impact on the application of cell-based therapy, and thus the treatment of a variety of cardiovascular diseases especially ischemic cardiovascular injuries. Over the past 11 years, I published over 50 papers with original data and book chapters.

My research activities have been supported continuously by NIH and AHA grants without interruption since 2004, including a 5-year NIH Physician-Scientist Career Development Award (K08), a NIH RO1 grant (5/2010-5/2016), AHA Grant-in-Aid, AHA Summer Undergraduate Training Grant, and very recently another RO1 ward (9/2015-8/2019).

Another RO1 proposal was just reviewed recently (6/2015) with a percentile of 14%. It is now under consideration for funding by NIH for year 2016.

In addition, I have been serving as local PI or co-investigator for over 40 clinical studies.

D. Actively involved in the academic activities at both national and international levels

I have been invited to give presentations at both national and international meetings almost every year since 2004. I have served on 5 national and international expert review panels, and as a reviewer for many high quality journals including “JACC”, Hypertension, and JCI.

E. Have been an active citizen in our OSU community and beyond

In the last several years, I have served on several committees including the Promotion and Tenure Committee for the Division of Cardiology, the committee for Pharmacy and Therapeutic Formulas at the OSU Medical Center. I have also been an active contributor to resident recruitment, fellow and faculty recruitments, and graduate training programs.

Academic Advising

2013 - 2014 Fengpeng Jia, The Ohio State University. Graduated 0.
 

Licenses

2003 - present Board Certified: American Board of Cardiovascular Medicine
2003 - present Medicine and Surgery License: State of Wisconsin Medical Board
2004 - present Medicine and Surgery License: State Medical Board of Ohio
2005 - present Board Certified: American Board of Cardiovascular Medicine
2000 - 2003 Medicine and Surgery License: State of Minnesota
2000 - 2010 Board Certified: American Board of Internal Medicine
 

Chapters in Books

Cardiac Electrophysiology Study: Basic Concepts and Techniques

Role of reactive oxygen species formation from oxidized low density lipoprotein in bone marrow stem cells

Secretome of Mesenchymal Stem cells

Prevention of Thromboembolism in Atrial Fibrillation: Coumadin

 

Degrees

1984 M.D., Hunan Medical University

1992 M.S., Queen's University

1995 Ph.D., Queen's University

 

Editorial Activities

2007 - present Journal of Cell and Molecular Medicine
2007 - present Acta Pharmacologica Sinica
2008 - present PACE
2008 - present Phytotherapy Research
2009 - present American Journal of Physiology - Heart and Circulatory Physiology
2009 - present Tissue Engineering
2009 - present Clinical and Experimental Pharmacology and Physiology
2009 - present The Open Microcirculation & Microvascular Journal
2009 - present Journal of Oncology
2010 - present Antioxidants & Redox Signaling (ARS)
2010 - present World Journal of Stem Cells
2010 - present Journal of Cellular Physiology
2010 - present Cancer Letters
2010 - present Journal of Interventional Cardiac Electrophysiology
2011 - present International Journal of Clinical and Experimental Medicine
2011 - present Journal of the American College of Cardiology
2012 - present Cell Death and Diseases
 

Honors

1984 - present First Academic Award.
1990 - 1991 Dean's Award. Queen's University.
1991 - 1992 Graduate Award.
1991 - 1992 Eldon Boyd Fellowship.
1993 - 1995 Studentship.
1994 - present Conference Award. University Sponsored.
2001 - 2002 Cardiology Fellows Forum of Excellence. American Heart Association.
2002 ACC Travel Award. American College of Cardiology.
2002 Lillehei Fellowship.
2002 Finalist for Melvin L. Marcus Young Investigator Award in Cardiovascular Science. American Heart Association.
2006 - present ASCI/AAP Travel Award. ASCI/AAP.
2013 - present Dedicated Service Award. College of Medicine Educational Program (Ambulatory Care).
 

Journal Articles

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"Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury.." Journal of molecular and cellular cardiology. Vol. 80, (March 2015.): -.

 

Reference Works

January 1987 Liu ZG, Zhang T, Duan CG, Xiu RJ."Preliminary study on the inhibitory action of compound 24 on antiogenesis induced by S-180 in chicken chario-allantoic membrane" . : 67
January 1994 Liu ZG, Marks GS, Brien JF, Maurice DH, Nakatsu K."Characteristics of nitric oxide sequestration by bovine vascular smooth muscle" . : A360
January 1996 Liu ZG, Rudd MA, Loscalzo J."Transnitrosation reactions in the metabolism of nitric oxide and their relationship to the biological actions of nitric oxide" . : I521
January 1997 Rudd MA, Liu ZG, Zai A, Loscalzo J."Platelet membrane thiols regulate cellular entry and activity of nitric oxide" . : I547
January 1997 Liu ZG, Zai A, Scribner AW, Loscalzo J."S-Transnitrosation reactions involving plasma membrane thiol groups are mechanistic determinants of the biological effects of S-nitrosothiols" . : I675
January 2002 Liu ZG, Jiang Y, Gupta K, Hao H, Sikora J, Blackstad M, McFalls E, Verfaillie CM, Bache RJ."Developmental expression of nitric oxide synthase during stem cell differentiation into endothelial cells" . : II-177
January 2004 Liu ZG, Lou R, Jiang Y, Gupta K, Verfaillie C, Bache RJ."Dimerization of mitogen-activated protein kinase and auto-phosphorylation of Akt occur in the newly differentiated endothelial-like cells from adult bone marrow stem cells in vitro" . : 498A
January 2006 Chu L, Jiang Y, Hao H, Wei Q, Xia Y, Verfaillie C, Zweier J, Liu ZG."Oct-4 expression and differentiation of bone marrow stem cells into endothelial cells are independent of the inhibition of nitric oxide synthase in vitro" . : A1126
January 2007 Xu J, Liu XF, Gupta K, Jiang Y, Hao H, Verfaillie CM, Zweier J, Liu ZG."STAT-3 and p42/44 MAPK are dynamically phosphorylated during bone marrow stem cell differentiation into endothelial cells" . : A1427
January 2007 Xu J, Liu XF, Gupta K, Jiang Y, Hao H, Vergaillie C, Zweier J, Liu ZG."Phosphorylated Akt is critical to the differentiation of bone marrow stem cells into endothelial cells" . : 385A
January 2007 Chu L, Jiang Y, Hao H, Verfaillie C, Zweier J, Liu ZG."Exogenous nitric oxide increases the expression of Oct-4 and may modify bone marrow stem cell differentiation into endothelial cells in vitro" . : 401A
January 2009 Doshi AA, Fitzpatrick A, Love CJ, Daoud EG, Kalbfleisch SJ, Augostini RS, Houmsse M, Hart DT, Liu ZG, Weiss R, Rooney T, Schilling K, Danker J, Rhodes T, Gangasani A, Hummel JD."Identification of a Novel Mechanism for Inappropriate Accelerometer Activation during Diagnostic Fluoroscopy" . : S190-S191
January 2010 Doshi A, Stohr E, Dutro M, Daoud EG, Weiss R, Augostini RS, Love CJ, Kalbfleisch SJ, Houmsse M, Hart DT, Hasan A, Liu ZG, Rhodes T, Tyler J, Rhine D, Rooney T, Hummel JD."Initial Performance Data of a Defibrillation Lead Utilizing the Draft IS4 Connection System" . : S21
January 2010 Boyd JM, Southall R, Augostini RS, Daoud EG, Hart D, Houmsse M, Kalbfleisch SJ, Liu ZG, Love CJ, Weiss R, Hummel JD."Evaluation of Complications During Planned Inpatient Initiation of Antiarrhythmic Medications" . : S280
May 2011 Bittenbender PM, Parekh A, Stephens J, Tyler J, Amin A, Rhine D, Tsai S, Hamam I, Rhodes TE, Hart DT, Houmsse M, Kalbfleisch SJ, Liu ZG, Love CJ, Augostini RS, Hummel JD, Daoud EG, Weiss R."Outcomes with Remote Magnetic Navigation for Ablation of Atrial Fibrillation" .
May 2011 Snider MJ, Boyd JM, Hirsch A, Houmsse M, Daoud EG, Hummel JD, Kalbfleisch SJ, Augostini RS, Weiss R, Hart DT, Love CJ, Liu ZG, Rhodes TE, Porter K, Carnes CA."Dronedarone: Real Life Experience And Follow Up" .
May 2011 Hamam IR, Daoud EG, Tsai S, Rhine D, Tyler J, Weiss R, Houmsse M, Love CJ, Kalbfleisch SJ, Augostini RS, Hart DT, Rhodes TE, Liu ZG, Hummel JD."Impact of Elevated International Normalized Ratio and Activated Clotting Time on Unfractionated Heparin Dosing for Ablation of Atrial Fibrillation" .
March 2013 Hamam, I MD; Daoud, E MD; Winner, M MD; Kamalov, G MD; Torres, J MD; Weiss, R MD; Kalbfleisch, S MD; Houmsse, M MD; Augostini, A MD; Love, C MD; Liu, Z MD; Tyler, J MD; Sachdev, M MD; Rhodes, T MD; Hummel, J MD."Arrhythmias" .

Presentations

Nitric oxide release following glyceryl trinitrate interaction with vascular smooth muscle is not mediated by hemoprotein

Approaches to the identification of nitric oxide receptors in vascular smooth muscle

Mechanisms of Ventricular Tachycardia and Management

Cardiovascular Diseases and Stroke

Sudden Cardiac Death: Mechanisms and Management

Unique Biological Behaviors of the Newly Differentiated Endothelial Cells from Bone Marrow Stem Cells and Possible Mechanisms

Update on Atrial Fibrillation

Catheter-Based Approaches to the Treatment of Atrial Fibrillation

Development of New Drugs with Cultured Bone Marrow Stem Cells

Evaluation and Management of Ventricular Tachycardia

New Strategies in the Management of Atrial Fibrillation

Evaluation and Management of Syncope

Expression of Akt/MAPK Signal Transduction Pathway during Bone Marrow Stem Cell Differentiation into Endothelial Cell

Current Status on the Management of Atrial Fibrillation

Bone Marrow Stem Cells and Vascular Repair

Rhythm vs Rate Control in the Management of Atrial Fibrillation

Role of the Cardiologist in the Management of Stroke

Dyspnea: Cardiac vs Pulmonary

Atrial Fibrillation and Other Arrhythmias/Devices

Advances in the Modalities and Treatment of Cardiac and Vascular Patients

ECG Analysis and Troubleshooting

Characteristics of the Newly Differentiated Endothelial Cells from Bone Marrow Stem Cells and Possible Mechanisms

Cell differentiation and mechanisms

Superventricular tachycardia: evaluation and management

Bradycardia Stored Electrogram

PFO and Stroke

Hyperlipidemia and Bone Marrow Stem Cells

Impaired endothelial differentiation from bone marrow stem cells: a novel mechanism for cardiovascular diseases

Cardiovascular Risk Factors and Bone Marrow Stem Cells

Therapies for ventricular arrhythmia:Indications for ICDs

Ventricular Arrhythmia: Etiology and Management

Impact of Hyperlipidemia on Bone Marrow Stem Cells: A Novel Mechanism for the Development of Cardiovascualr Diseases in Hyperlipidemic Patients

Bone Marrow Stem Cells: Characteristics adn their Potential Clinical Applications

Effects of ox-LDL on bone marrow stem cells: A new look at the mechanisms for the development of cardiovascular diseases in hyperlipidemia

The Sixth Yellow River International Cardiovascular Conference

Endothelial differentiation of bone marrow stem cells: characteristics and possible mechanisms

Impact of hyperlipidemia on bone marrow stem cells: a novel mechanism for the development of cardiovascular diseases in hyperlipidemic patients

Bone marrow stem cells: characteristics and their potential clinical applications

Bone marrow stem cells: biology and potential clinical application in cardiovascular system

Sudden Cardiac Arrest: Etiology and Management

Ventricular Arrhythmia and Coronary Artery Disease

Induced Pluripotent Stem Cells (iPSCs) and Reprogramming

Redox Biology/Proteinomics/Systems Biology

Impact of cardiovascular risk factors on bone marrow stem cells and their endothelial differentiation

Diabetes and bone marrow stem cells: new mechanism for cardiovascular diseases in DM

Indications for pacing therapy

Ventricular Arrhythmia and Management during Coronary Intervention

Endothelial differentiation of bone marrow stem cells and mechanisms

Ox-LDL and bone marrow stem cells: a new mechanisms for the development of cardiovascular diseases in hyperlipidemia

Diabetes and bone marrow stem cells: challenges in cell-based therapy in diabetic patients

Translational research in cardiovascular medicine

Effects of hyperlipidemia on bone marrow stem cells and their endothelial differentiation

Updates on bone marrow stem cells: biology and clinical applications

Bone marrow stem therapy in cardiovascular system: promises and challenges

Role of oxidative stress in endothelial differentiation of bone marrow stem cells

Bone marrow stem cells and their endothelial differentiation: mechanisms and clinical implications

Overexpression of antioxidant enzymes promotes the recovery of ischemic limb in mice

Ox-LDL impairs the survival of bone marrow stem cells partially through membrane damage independent of ROS production in vitro

27-nt microRNA suppresses the expression of endothelial nitric oxide synthase predominantly through nuclear transcription factor Ap-1

Endothelial differentiation of bone marrow stem cells and mechanisms

Chads2 and Chads2vasc Scores Predict the Risk for Left Atrial Thrombus in Patients with Atrial Fibrillation

Role of reactive oxygen species in mediating the effect of ox-LDL on bone marrow stem cells

Importance of Routine Treadmill Exercise Stress Testing After Subcutaneous Implantable Cardioverter Defibrillator Implantation

Super-Response in Patients Undergoing CRT Upgrade for Significant RV Pacing

 

Professional Activities

present International Symposium of Cardiovascular Pharmacology and Physiology.
present International Summit for Stroke.
present IBHRExAM Review Course. The Ohio State University Medical Center. Columbus, OH.
present IBHRExAM Review Course. The Ohio State University Medical Center. Columbus, OH.
present Expert Reviewer. Romanian National Council for Scientific Research.
present The Seventh Yellowriver International Cardiovascular Conference.
present The Ninth Yellow River International Cardiovascular Conference.
present The International Symposium on Genetics and Epigenetics in Cardiovascular Development and Diseases.
present Advances in the Modalities and Treatment of Cardiac and Vascular Patients. Pikeville Medical Center.
present New Strategies in the Management of Atrial Fibrillation. The Ohio State University Medical Center. Columbus, OH.
present The Sixth Yellowriver International Cardiovascular Conference.
2007 - present Chongqing Medical University.
1990 - 1994 Heart and Stroke Foundation of Canada. Kingston, ON.
2005 - 2008 Nanjin University School of Medicine.