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Dr. Hackshaw's OSUPro Profile


Staff photo

480 W 9th Ave
Columbus, OH 43210

 

Current OSU Appointments

Associate Professor, Immunology & Rheumatology

Associate Professor, SBS-Molec & Cellular Biochem

Physician, FGP-Immunology & Rheumatology

 

Clinical Interest

Fibromyalgia, Systemic Lupus Erthematosus and Vasculitis

Biographical

I graduated from Baylor College of Medicine in 1983. I completed a residency in Internal Medicine at Harlem Hospital Center (College of Physicians and Surgeons of Columbia University) in 1986. I completed a 1 year chief residency in Internal Medicine at Harlem and then did a 3 year Rheumatology Fellowship (research fellowship) at the University of Colorado Health Sciences Center in Denver working in the laboratory of Dr. Thomas Santoro and under the directorship of Dr. William P. Arend (1987 – 1990). The focus of his work at that time was membrane biochemistry. Several important studies were published at that time including identification that elevated Urine LTE4 levels were associated with SLE disease activity. I came to The Ohio State University in 1990 and have been an independent investigator since that time. A Physician Scientist Award under the mentorship of Dr. Ing-Ming Chiu was obtained in 1991 “ Cloning and Characterization of the Mouse FGF-1 Gene”(1991 – 1996). An R01 Award as Principal Investigator was obtained in 2001 “Chronic Pain, Suprapspinal Serotonin and Neurotrophic Factors”. (2001 – 2006). I became Rheumatology Fellowship Program Director in 2004. Other important collaborations have been exercise studies in Osteoarthritis with OSU collaborators and proposed studies on Curcumin in Osteoarthritis with Zhongfa Liu, Ph.D. – OSU – Pharmacy. I have 4 children and my wife Dawn S. Hackshaw, M.D. (OSU, 1992) is a practicing pediatrician in Columbus, Ohio.

Noteworthy Graduate Narrative

Noteworthy Accomplishments of Undergraduate and Graduate Students



1.Dylan Wirtz, M.D. : Pulmonary Fellow, OSU

2. Selma Mohammed, M.D. Ph.D. Mayo Clinic, Gastorenterology

3. Zhanna Mikulik, M.D. Assistant Professor, Clinical , OSU

4. Madhu Mehta, M.D. Assistant Professor, Clinical, OSU

5. Chalonda Handy, Ph.D. Post Doctoral Fellow: Emory University

6. Regina Buccello-Stout, Ph.D. Deputy Project Scientist for the Flight Analog Project in the Human Adaptation and Countermeasures Division , NASA

7 Natosha Gatson, M.D., Ph.D. Neurology Fellow: OSU

8. Syed-Rehan Hussain, Ph.D. Research Scientist: Nationwide Children’s Hospital

9. Francesca Madiai, Ph.D. : Clinical Research Coordinator, Division of Rheumatology , OSU

10. Nkenge Jackson, M.D. : Obstetrician, Cincinnati, Ohio

11. Valerie K. Ibom Reed M.D. Assistant Professor Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX



Reed VK, Woodward WA, Zhang L, Strom EA, Perkins GH, Tereffe W, Oh JL, Yu K, Bedrosian I, Whitman GJ, Buchholz TA, Dong L. Automatic Segmentation of the Whole Breast using an Atlas Approach and Deformable Image Registration. International Journal of Radiation Oncology Biology and Physics. e-Pub 9/2008.



Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy AM, Feig BW, Pisters PW, Ajani JA, Crane CH. Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys 71(3):741-7, 7/1/2008. PMID: 18164837.



Reed VK, Cavalcanti JL, Strom EA, Perkins GH, Oh JL, Tereffe W, Yu TK, Yeung H, Whitman GJ, Bedrosian I, Macapinlac HA, Buchholz TA, Woodward WA. Risk of subclinical micrometastatic disease in the supraclavicular nodal bed according to the anatomic distribution in patients with advanced breast cancer. Int J Radiat Oncol Biol Phys 71(2):435-40, 6/1/2008. PMID: 18164831.

Academic Advising

1992 - 1993 Tammy Bully The Ohio State University.
1998 - 2001 Susan Burghes The Ohio State University. Graduated 2001.
1999 - 2002 Ning Zhi The Ohio State University. Graduated 1999.
2002 - 2003 Dylan Wirtz The Ohio State University.
2002 - 2003 Theresa Rogers The Ohio State University.
2002 - 2004 Alec Clairmont The Ohio State University.
2002 - 2004 Tyler Ibom The Ohio State University.
2009 - 2011 Matthew Handy The Ohio State University.
 

Certifications

1987 - present Board Certified Internal Medicine: American Board of Internal Medicine
1990 - present Medical Licensure: State Medical Board of Ohio
1994 - present Board Certified: American Board of Internal Medicine
1985 - 1991 Medical Licensure: State Medical Board of New York
 

Chapters in Books

Hackshaw KV. "Fibromyalgia." In The 5-Minute Neurology Consult. Edited by Lynn DJ, Newton HB, Rae-Grant AD,. 198-199. Philadelphia: Lippincott Williams & Wilkins, January 2004.

Hackshaw KV, Burns LM. "Fibromyalgia." In The 5-Minute Neurology Consult. -. Philadelphia: Lippincott Williams & Wilkins, November 2011.

 

Degrees

1979 B.S., City University of New York, The Brooklyn College

1983 M.D., Baylor College of Medicine

1990 None Indicated, University of Colorado Health Sciences Center

 

Editorial Activities

present Reviewer for Pediatric Rheumatology
2012 - present Journal Immunotherapy
2012 - present Life Sciences
2012 - present Research Communication in Molecular Pathology & Pharmacology
 

Honors

1987 Diplomate. American Board of Internal Medicine (ABIM).
1992 Physician Scientist Award. NIAID.
2009 Alpha Omega Alpha. ..
 

Journal Articles

Madiai F, Hackshaw KV, Chiu I-M.. "Cloning and Characterization of Murine FGF-1 Gene." Gene. Vol. 179, (January 1996.): 231-236.

Madiai F; Hussain SR; Goettl VM; Burry RW; Stephens RL Jr; Hackshaw KV. "Upregulation of FGF-2 in Reactive Spinal Cord Astrocytes Following Unilateral Lumbar Spinal Nerve Ligation.." Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale. Vol. 148, no. 3. (February 2003.): 366-376.

Hackshaw KV, Lynn DJ, Newton HB, Rae-Grant AD. "Fibromyalgia." The 5-Minute Neurology Consult. (January 2004.): -.

Alzate O; Hussain SR; Goettl VM; Tewari AK; Madiai F; Stephens RL Jr; Hackshaw KV. "Proteomic Identification of Brainstem Cytosolic Proteins in a Neuropathic Pain Model.." Brain Research. Molecular Brain Research. Vol. 128, no. 2. (September 2004.): 193-200.

Goettl VM; Hussain SR; Alzate O; Wirtz DJ; Stephens RL Jr; Hackshaw KV. "Differential Change in mRNA Expression of p75 and Trk Neurotrophin Receptors in Nucleus Gracilis After Spinal Nerve Ligation in the Rat.." Experimental Neurology. Vol. 187, no. 2. (June 2004.): 533-536.

Keefe FJ; Affleck G; France CR; Emery CF; Waters S; Caldwell DS; Stainbrook D; Hackshaw KV; Fox LC; Wilson K. "Gender Differences in Pain, Coping, and Mood in Individuals Having Osteoarthritic Knee Pain: a Within-Day Analysis.." Pain. Vol. 110, no. 3. (August 2004.): 571-577.

France CR; Keefe FJ; Emery CF; Affleck G; France JL; Waters S; Caldwell DS; Stainbrook D; Hackshaw KV; Edwards C. "Laboratory Pain Perception and Clinical Pain in Post-Menopausal women and Age-Matched Men with Osteoarthritis: Relationship to Pain Coping and Hormonal Status.." Pain. Vol. 112, no. 3. (December 2004.): 274-281.

Madiai F, Goettl VM, Stephens RL, Hackshaw KV. "Ciliary Neutrotrophic Factor Immunoreactivity is Not Associated with Reactive Astrocytes in the Rat Spinal Cord Following Unilateral Spinal Nerve Ligation." Neuroscience Res. Comm. Vol. 34, (January 2004.): 122-129.

Madiai F; Goettl VM; Hussain SR; Clairmont AR; Stephens RL Jr; Hackshaw KV. "Anti-Fibroblast Growth Factor-2 Antibodies Attenuate Mechanical Allodynia in a Rat Model of Neuropathic Pain.." Journal Of Molecular Neuroscience: MN. Vol. 27, no. 3. (January 2005.): 315-324.

Rovin BH; Tang Y; Sun J; Nagaraja HN; Hackshaw KV; Gray L; Rice R; Birmingham DJ; Yu CY; Spetie DN; Aziz A; Hebert LA. "Clinical Significance of Fever in the Systemic Lupus Erythematosus Patient Receiving Steroid Therapy.." Kidney International. Vol. 68, no. 2. (August 2005.): 747-759.

Binns BC; Huang Y; Goettl VM; Hackshaw KV; Stephens RL Jr. "Glutamate Uptake is Attenuated in Spinal Deep Dorsal and Ventral Horn in the Rat Spinal Nerve Ligation Model.." Brain Research. Vol. 1041, no. 1. (April 2005.): 38-47.

Birmingham DF, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Yu CY, Malarkey WB, Hebert LA.. "Fluctuation in Self-Perceived Stress and Increased Risk of Flare in Patients with Lupus Nephritis Carrying the Serotonin Receptor 1A – 1019 G Allele." Arthritis and Rheumatism. Vol. 10, no. 54. (January 2006.): 3291-3299.

Emery CF, Keefe FJ, Affleck G, Waters S, Fondow MD, McKee DC, France JL, Hackshaw KV, Caldwell DS, Stainbrook D. "Effects of a Brief Coping Skills Training Intervention on Nociceptive Flexion Reflex Threshold in Patients Having Osteoarthritic Knee Pain: a Preliminary Laboratory Study of Sex Differences." J Pain Symptom Manage. Vol. 31, no. 3. (January 2006.): 262-269.

Wu LC, Goettl VM, Madiai F, Hackshaw KV, Hussain SR.. "Reciprocal Regulation of Nuclear Factor Kappa B and its Inhibitor ZAS3 After Peripheral Nerve Injury.." BMC Neurosci. Vol. 7, no. 1. (January 2006.): 4-.

Chauhan A, Mikulik Z, Hackshaw KV.. "Multicentric Reticulohistiocytosis with Positive Anticyclic Citrullinated Antibodies.." J Natl Med Assoc. Vol. 99, no. 6. (January 2007.): 678-680.

Yang Y, Chung EK, Wu YL, Savelli SL, Nagaraja HN, Zhou B, Hebert M, Jones KN, Shu Y, Kitzmiller K, Blanchong CA, McBride KL, Higgins GC, Rennebohm RM, Rice RR, Hackshaw KV, Roubey RA, Grossman JM, Tsao BP, Birmingham DJ, Rovin BH, Hebert LA, Yu CY. "Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number is a Risk Factor for and High Copy Number is a Protective Factor Against SLE Susceptibility in European America." Am J Hum Genet.. Vol. 80, no. 6. (January 2007.): 1037-1054.

Wu H, Birmingham DJ, Rovin B, Hackshaw KV, Haddad N, Haden D, Yu CY, Hebert LA. "D-dimer level and the risk for thrombosis in systemic lupus erythematosus." Clin J Am Soc Nephrol.. Vol. 3, no. 6. (November 2008.): 1628-1636.

McKinley A, Park E, Spetie D, Hackshaw KV, Nagaraja S, Hebert LA, Rovin BH.. "Oral cyclophosphamide for lupus glomerulonephritis: an underused therapeutic option.." Clin J Am Soc Nephrol.. Vol. 4, no. 11. (November 2009.): 1754-1760.

Marquardt AL, Hackshaw KV. "Reactive arthritis associated with hidradenitis suppurativa." J Natl Med Assoc.. Vol. 101, no. 4. (April 2009.): 367-369.

Liu S; Madiai F; Hackshaw KV; Allen CE; Carl J; Huschart E; Karanfilov C; Litsky A; Hickey CJ; Marcucci G; Huja S; Agarwal S; Yu J; Caligiuri MA; Wu LC. "The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.." Plos One. Vol. 6, no. 3. (March 2011.): e17161-.

Amato AA, Tawil R, Kissel J, Barohn R, Freimer ML, Hackshaw KV, Lawson V, et al. "A Randomized Pilot Trial of Etanercept in Dermatomyositis." Ann Neurol. no. 70. (January 2011.): 427-436.

Aelion J, Afif N, Hackshaw KV et al.. "Inhibition of Joint Damage and Improved Clinical Outcomes with Rituximab plus Methotrexate in early active Rheumatoid Arthritis: the IMAGE Trial." Ann Rheum Dis. no. 70. (January 2011.): 39-46.

Brian C. Focht, Matthew J. Garver, Steven T. Devor, Justin Dials, Mark Rose, Alex R. Lucas, Charles F. Emery, Kevin Hackshaw, & W. Jack Rejeski. "Improving Maintenance of Physical Activity in Knee Osteoarthritis Patients Trial-Pilot (IMPACT-P): Design and Methods." Contemp Clin Trials. Vol. 33(5), (September 2012.): 976-82.

Garver M, Focht B, Dials J, Rose M, Lucas A, Devor S, Emery CF, Hackshaw KV, Rejeski W.. "Weight Status and Differences in Mobility Performance, Pain Symptoms and Physical Activity in Older, Knee Osteoarthritis Patients." Journal of Arthritis. Vol. 2014, (May 2014.): 7-.

Garver M, Focht B, Dials J, Rose M, Lucas A, Devo S, Emery CF, Hackshaw KV, Rejeski W. "Weight Status and Differences in Mobility Performance, Pain Symptoms and Physical Activity in Older, Knee Osteoarthritis Patients." Journal of Arthritis. -.

 

Reference Works

January 1989 Malone D, Hackshaw K, Westcott J."Kinetics of Histamine, Leukotriene and Prostaglandin Release by Joint Mast Cells in Situ." .
January 1989 Hackshaw KV, Santoro TJ."Aberrations in PLC Activity in MRL-1pr/ 1pr Macrophages" .
January 1989 Hackshaw KV, Santoro TJ."Enhanced Phospholipase A2 Activity in Macrophages from Autoimmune 1pr-Mice." .
January 1990 Hackshaw KV, Santoro TJ."Transmembrane Signaling in Macrophages (MO) from Autoimmune MRL-1pr/ 1pr Mice" .
January 1990 Hackshaw KV, Santoro TJ."Transmembrane Signaling in Macrophages (MO) from Autoimmune MRL-1pr/ 1pr Mice" .
January 1991 Hackshaw KV."Heparin Binding Growth Factors: Role in Autoimmunity" .
January 1992 Lakshmanan RR, Hackshaw KV."The Role of Acidic Fibroblast Growth Factor in Experimental Autoimmunity" .
January 1993 Apseloff G, Whitacre C, Weisbrods SE, Kresie ME, Shepard DR, Hackshaw KV, Gerber N."Gallium Suppresses Lupus in MRL/1pr Mice" .
January 1993 Hackshaw KV, Madiai F, Chiu I-M."Cloning and Characterization of Murine Acidic Fibroblast Growth Factor Gene" .
January 1994 Apseloff G, Hackshaw KV, Whitacre C, Weisbrode SE, Gerber N."Gallium Nitrate Suppresses Lupus in MRL/1pr Mice" .
January 1994 Hackshaw KV, Shi Y, Bradywine S, jones K, Westcott JY."A Pilot Study of Zileuton, A Novel Specific 5-Lipoxygenase Inhibitor in Patients with Systemic Lupus Erythematosus" .
January 1995 Weisbrode SE, Apseloff G, Hackshaw KV, Whtiacre C, Gerber N."Gallium Nitrate Ameliorates Spontaneous Lesion in MRL/1pr Mice but Induces Osteosclerosis" .
January 1995 Weisbrode SE, Apseloff G, Hackshaw KV, Whitacre C, Gerber N."Gallium Nitrate Reduces Lesions in MRL/1pr Mice" .
January 1995 Gray LS, Kunesh SL, Hackshaw KV, Whitacre C, Gerber N."Fibroblast Growth Factor-2 is Present in Synovial Fluids from Arthritic Patients" .
January 1997 Smart P, Waylonis G, Hackshaw KV."The Immunologic Profile of Patients with Fibromyalgia" Columbus. : 231
October 2009 Lai W, Barnes S, Zhang Y, Hackshaw KV, Wolfe T."Assessment of Pregabalin Utilization in Patients with Fibromyalgia at a University-Based Rheumatology Clinic" Chicago. : 1425
January 2012 Brian C. Focht, Matthew J. Garver, Steven T. Devor, Justin Dials, Charles Emery, and Kevin Hackshaw."Group-Mediated Activity Counseling and Self-Reported Physical Activity in Older, Knee Osteoarthritis Patients: Evidence from the IMPACT-P Trial" .
May 2012 Focht, BC, Garver, MJ, Devor, ST, Dials, J, Rose, M, Lucas, A, Emry, CF, Hackshaw, K, Rejeski, WJ."BMC Musculoskeletal Disorders" Columbus.
May 2012 Brian C. Focht, Matthew J. Garver, Steven T. Devor, Justin Dials, Mark Rose, Alex Lucas, Charles F. Emery, Kevin V. Hackshaw, W. Jack Rejeski."Improving Maintenance of Physical Activity in Knee Osteoarthritis Patients Trial - Pilot (IMPACT-P): Design and Methods" Columbus. : 976
July 2013 Hackshaw, Kevin V."Potential for a faster, simpler diagnosis for Fibromyalgia" Columbus.
Levine TD, Lawson V, Levine A, Hackshaw KV, Saperstein DS."Presented at the ACR National Meeting" .
Hackshaw KV."Presence of Small Fiber Neuropathy in a Cohort of Patients with Fibromyalgia" .

Presentations

"Fibromyalgia; Pathogenesis and Treatment." Presented at National Medical Association Conference, New Orleans, LA, US|USA. (August 1999)

"Pain; Pathogenesis and Treatment." Presented at Internal Medicine Grand Rounds, Columbus, OH, US|USA. (June 2002)

"What's New in Fibromyalgia." Presented at National Medical Association Conference, Philadelphia, PA, US|USA. (August 2003)

"Fibromyalgia: Pathogenesis, Treatment and Research Advances." Presented at Department of Internal Medicine Grand Rounds, Louisville, KY, US|USA. (October 2004)

"Fibromyalgia Update. Biologics Advances in Rheumatology." Presented at National Medical Association Conference, Honolulu, HI, US|USA. (August 2004)

"Neuropathic Pain: Pathogenesis, Clinical Spectrum and Treatment." Presented at Department of Physical Medicine Grand Rounds, Columbus, OH, US|USA. (December 2005)

"Fibromyalgia: Pathogenesis, Diagnosis, and Treatment." Presented at Internal Medicine Grand Rounds, Columbus, OH, US|USA. (December 2005)

"Biologics Update." Presented at National Medical Association Conference, New York, NY, US|USA. (July 2005)

"Neuropsychiatric Lupus." Presented at Internal Medicine Grand Rounds, Columbus, OH. (September 2008)

"Fibromyalgia." Presented at Family Medicine Grand Rounds, Columbus, OH. (April 2009)

"Fibromyalgia: Pathogensis Diagnosis and Treatment." Presented at Neurology Grand Rounds, Columbus, OH. (March 2009)

"Fibromyalgia: Pathogenesis, Diagnosis and Treatment." Presented at Internal Medicine Grand Rounds, Columbus, OH. (August 2011)

"Group-Mediated Activity Counseling and Self-Reported Physical Activity in Older, Knee Osteoarthritis Patients: Evidence from the IMPACT-P Trial." Presented at 2012 Society of Behavioral Medicine Conference, New Orleans, LA. (April 2012)

"Presence of Small Fiber Neuropathy in a Cohort of Patients with Fibromyalgia." Presented at ACR Annual Meeting, Washington, DC, US|USA. (November 2012)

"Common Rheumatologic Conditions Encountered in Family Medicine." Presented at The Ohio State University - Family Medicine Grand Rounds, Columbus, Ohio. (December 2012)

"A Bloodspot-Based Diagnostic Test for Fibromyalgia and other Central Sensitivity Syndromes." Presented at Midwest Regional Pain Interest Group Meeting, Cincinnati, Ohio. (August 2013)

 

Professional Activities

1995 - present NIH Peer Review Consultant.
2012 - present NIH Somatosensory Chemosensory Section.
1994 VI Annual Ohio State University Molecular Biology - DNA Virus Gene Expression Study. Stone Laboratory Meeting.
2004 - 2005 NIH Chronic Fatigue Syndrome Study Section.
2008 - 2009 NIH Stimulus Grants Special Emphasis Panel.
2009 - 2012 NIH Somatosensory Chemosensory Study Section.
 

Unpublished Works

Huang W, Bansode R, Mehta M, Mehta KD. Ablation of PKC ameliorates obesity, insulin resistance and hepatic steatosis in obese leptin-deficient ob/ob mice. January 2011.