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Ing Ming Chiu, PhD


Staff photo

480 Medical Center Drive
Columbus, OH 43210

 

Current OSU Appointment

Professor Emeritus, Immunology & Rheumatology

 

Chapters in Books

Robbins, K.C., Igarashi, H., Gazit, A., Chiu, IM, Tronick, S.R., and Aaronson, S.A.. "Establishing the link between human proto-oncogenes and growth factors." In Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and other Agents. Edited by Castellani, A.. 459-470. New York: Plenum Press, January 1985.

Igarashi, H., Gazit, A., Chiu, IM, Srinivasan, A., Yaniv, A., Tronick, S.R., Robbins, K.C., and Aaronson, S.A.. "Normal human sis/PDGF-2 gene expression induces cellular transformation." In Cancer Cell: Growth Factors and Transformation. Vol. 3. Edited by Feramisco, J., B. Ozanne, and C. Stiles. 159-166. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, January 1985.

Chiu, IM, Sandberg, P., and Wang, W.-P.. "Brain-derived heparin-binding growth factors and their oncogenic homologs." In Tropic Factors and the Nervous System. Edited by Horrocks, L.A., N.H. Neff, A.J. Yates, and M. Hadjiconstantinou. 55-57. New York, NY: Raven Press, January 1990.

Poulin, M.L., and Chiu, IM. "Direct cloning of ?gt11 cDNA inserts into a plasmid vector." In Methods in Molecular Biology: Protocols for Gene Analysis. Vol. 31. Edited by Harwood A.. 9-18. Totowa, NJ: Humana Press, January 1994.

Myers, R.L., and Chiu, IM. "Single primer-mediated polymerase chain reaction." In Methods in Molecular Biology: Protocols for Gene Analysis. Vol. 31. Edited by Harwood A.. 307-315. Totowa, NJ: Humana Press, January 1994.

 

Conferences

Callahan, R., Chiu, IM, Horn, T., Ali, I., Robbins, J., Aaronson, S., and Schlom, J.. "A new class of human endogenous retroviral genes." RNA Tumor Viruses in Human Cancer. (International Research Conference on RNA Tumor Viruses in Human Cancer). (January 1985). 76-92.

Chiu, IM. "Potential of growth factors and oncogenes in cancer treatment." Proceedings of the First IST-OSU Workshop on Development of Therapeutics: Experimental and Clinical. (January 1988). 9-13.

 

Degrees

1974 B.S., National Taiwan University

1974 B.S., National Taiwan University

1981 Ph.D., Florida State University

 

Editorial Activities

present Journal of Virology
present Journal of Neurochemistry
present Journal of Experimental Medicine
present International Journal of Developmental Biology
present In Vitro Cellular and Developmental Biology
present DNA and Cell Biology
present Differentiation
present Brain Research
present Molecular and Cellular Biology
present J. Biomedical Sciences
present International Journal of Oncology
present Experimental Cell Research
present Development
present Cancer Research
present Oncogene
present Nature Medicine
present Proceedings of National Academy of Science
 

Honors

1972 - 1973 Presidential Award for Best Athletes. National Taiwan University.
1973 - 1974 Excellent Student Award.
1974 Chinese Cultural and Scientific Scholarship.
1986 Research Challenge Award. The Ohio State University.
1988 - 1990 Ohio Cancer Research Award, Columbus, Ohio.
1990 - 1995 Research Career Development Award. National Cancer Institute.
 

Journal Articles

Sittman, DB, Chiu, IM, Pan, CJ, Cohn, RH, Kedes, LH, Marzluff, WF. "Isolation of Two Clusters of Mouse Histone Genes." Proc. Natl. Acad. Sci. USA. Vol. 78, (January 1981.): 4078-4082.

Chiu, IM. "Uncoordinated Synthesis of Histone H1 in Cells Arrested in the G1 Phase." Biochim. Biophys. Acta.. Vol. 699, (January 1982.): 173-182.

Chiu, IM, Anderson, PR, Aaronson, SA, Tronick, SR. "Molecular Cloning of the Unintegrated Squirrel Monkey Retrovirus Genome: Organization and Distribution of Related Sequences in Primate DNAs." J. Virol.. Vol. 47, (January 1983.): 434-441.

Yuasa, Y, Gol, RA, Chang, A, Chiu, IM, Reddy, EP, Tronick, SR, Aaronson, SA. "Mechanism of Activation of an N-ras oncogene of SW-1271 Human Lung Carcinoma Cells." Proc. Natl. Acad. Sci. USA. Vol. 81, (January 1984.): 3670-3674.

Chiu, IM, Reddy, EP, Givol, D, Robbins, KC, Tronick, SR, Aaronson, SA. "Nucleotide Sequence Analysis Identifies the Human C-Sis Proto-Oncogene as a Structural Gene for Platelet-Derived Growth Factor." Cell. Vol. 37, (January 1984.): 123-129.

Chiu, IM, Callahan, R, Tronick, SR, Scholm, J, Aaronson, SA. "Major pol Gene Progenitors in the Evolution of Oncoviruses." Science. Vol. 223, (January 1984.): 364-370.

Gazit, A, Igarashi, H, Chiu, IM, Srinivasan, A, Yaniv, A, Tronick, SR, Robbins, KC. "Expression of the Normal Human sis/PDGF-2 Coding Sequence Induces Cellular Transformation." Cell. Vol. 39, (January 1984.): 89-97.

Yaniv, A, Dahlberg, JE, Tronick, SR, Chiu, IM, Aaronson, SA. "Molecular Cloning of Integrated Caprine Arthritis Encephalitis Virus." Virol. Vol. 145, (January 1985.): 340-345.

Robbins, KC, Igarashi, H, Gazit, A, Chiu, IM, Tronick, SR, Aaronson, SA. "Establishing the Link Between Human Proto-Oncogenes and Growth Factors." Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and other Agents. (January 1985.): 459-470.

Graves, RA, Wellman, SE, Chiu, IM, Marzluff, WF. "Differential Expression of Two Clusters of Mouse Histone Genes." J. Mol. Biol.. Vol. 183, (January 1985.): 179-194.

Igarashi, H, Gazit, A, Chiu, IM, Srinivasan, A, Yaniv, A, Tronick, SR, Robbins, KC, Aaronson, SA. "Normal Human sis/PDGF-2 Gene Expression Induces Cellular Transformation." Cancer Cell: Growth Factors and Transformations. Vol. 3, (January 1985.): 159-166.

Igarashi, H, Gazit, A, Chiu, IM, Srinivasan, A, Yaniv, A, Tronick, SR, Robbins, KC, Aaronson, SA. "Expression of a Normal Growth Factor Gene Causes Morphologic Transformation." From Oncogenes to Tumor Antigens. (January 1985.): 3-15.

Chiu, IM,5 Huang, R, Aaronson, SA. "Genetics Relatedness Between Intracisternal A Particles and Other Major Oncovirus Genera." Virus Res.. Vol. 3, (January 1985.): 1-11.

Chiu, IM, Yaniv, A, Dahlberg, JE, Gazit, A, Skuntz, SF, Tronick, SR, Aaronson, SA. "Nucleotides Sequence Evidence for Relationship of AIDS Retrovirus to Lentiviruses." Nature. Vol. 317, (January 1985.): 366-368.

Callahan, R, Chiu, IM, Wong, JFH, Tronick, SR, Roe, BA, Aaronson, SA, Schlom, J. "A New Class of Endogenous Human Retroviral Genomes." Science. Vol. 228, (January 1985.): 1208-1211.

Hung, MC, Thompson, KL, Chiu, IM, Rosner, MR. "Characterization of Rodent Epidermal Growth Factor Receptor Transcripts Using a Mouse Genomic Probe." Biochem. Biophys. Res. Commun.. Vol. 141, (January 1986.): 1109-1115.

Chiu, IM, Skuntz, SF. "Nucleotide Sequence Analysis of Squirrel Monkey Retrovirus Reveals a Novel Primer-Binding Site for tRNA Lys 1,2." J. Virol. Vol. 58, (January 1986.): 983-987.

Jaye, M, Howk, R, Burgess, W, Ricca, GA, Chiu, IM, Ravera, MW, O'Brien, SJ, Modi, WS, Maciag, T, Drohan, W. "Human Endothelial Cell Growth Factor: Cloning Nucleotide Sequence and Chromosome Localization." Science. Vol. 233, (January 1986.): 541-545.

Yaniv, A, Dahlberg, J, Gazit, A, Sherman, L, Chiu, IM, Tronick, SR, Aaronson, SA. "Molecular Cloning and Physical Characterization of Integrated Equine Infectious Anemia Virus: Molecular and Immunologic Evidence of Its Close Relationship to Ovine and Caprine Lentiviruses." Virol. Vol. 154, (January 1986.): 1-8.

Rao, CD, Igarashi, H, Chiu, IM, Robbins, KC, Aaronson, SA. "Structure and Sequences of the Human C-sis/Platelet-Derived Growth Factor 2 (SIS/PDGF2) Transcriptional Unit." Proc. Nat'l. Acad. Sci. USA. Vol. 83, (January 1986.): 2392-2396.

Jaye, M, Modi, WS, Ricca, GA, Mudd, R, Chiu, IM, O'Brien, SJ, Drohan, WD. "Isolation of a cDNA Clone for the Human Laminin-B1 Chain and Its Gene Localization." Amer. J. Hum. Genet.. Vol. 41, (January 1987.): 605-615.

Chiu, IM. "Research perspectives: Oncogenes and human cancer." Res. Forum. Vol. 1, (January 1987.): 5-6.

Wang, WP, Lehtoma, K, Varban, ML, Krishnan, I, Chiu, IM. "Cloning of the Gene Coding for Human Class 1 Heparin-Binding Growth Factor and Its Expression in Fetal Tissues." Mol. Cell. Biol.. Vol. 9, (January 1989.): 2387-2395.

Chiu, IM. "Growth Factor Genes as Oncogenes." Mol. Chem. Neuropathol.. Vol. 10, (January 1989.): 37-52.

Chiu, IM, Wang, WP, Lehtoma, K. "Alternative Splicing Generates Two Forms of mRNA Coding for Human Heparin-Binding Growth Factor 1." Oncogene. Vol. 5, (January 1990.): 755-762.

Chiu, IM, Sandberg, P, Wang, WP. "Brain-Derived Heparin-Binding Growth Factors and Their Oncogenic Homologs." Tropic Factors and the Nervous System. Vol. 3, (January 1990.): 55-57.

Chiu, IM, Lehtoma, K. "Direct Cloning of cDNA Inserts From λgt11 Phage DNA Into a Plasmid Vector by a Novel and Simple Method." Genet. Anal. Techn. Appl.. Vol. 7, (January 1990.): 18-23.

Bunnag, P, Waddell, KS, Varban, ML, Chiu, IM. "Transformed Phenotype Conferred to NIH/3T3 Cells by Ectopic Expression of Heparin-Binding Growth Factor 1/Acidic Fibroblast Growth Factor." In Vitro Cell Dev. Biol.. Vol. 27A, (January 1991.): 89-96.

van de Winkel, JGJ, Ernst, LK, Anderson, CL, Chiu, IM. "Gene Organization of the Human High Affinity Receptor for IgG, FcγRI (CD64): Characterization and Evidence for a Second Gene." J. Biol. Chem.. Vol. 266, (January 1991.): 13449-13455.

Thornton, DE, Thiel, K, Payson, R, Balcerzak, SP, Chiu, IM. "Characterization of the 5q-Breakpoint in an Acute Nonlymphocytic Leukemia Patient Using Pulsed-Field Gel Electrophoresis." Am. J. Med. Genet.. Vol. 41, (January 1991.): 557-565.

Payson, RA, Wang, WP, Canatan, H, Chiu, IM. "An STS in a 5' Untranslated Exon of the Human Acidic Fibroblast Growth Factor (aFGF) Gene." Nucleic Acids Res.. Vol. 19, (January 1991.): 6657-.

Onda, H, Poulin, ML, Tassava, RA, Chiu, IM. "Characterization of a Newt Tenascin cDNA and Localization of Tenascin mRNA During Newt Limb Regeneration by in situ Hybridization." Devel. Biol.. Vol. 148, (January 1991.): 219-232.

Jhiang, SM, Chiu, IM, Mazzaferri, EL. "An STS in Human PTC Oncogene Located in 10q11.2." Nucleic Acids Res.. Vol. 19, (January 1991.): 4303-.

Wang, WP, Quick, D, Balcerzak, SP, Needleman, SW, Chiu, IM. "Cloning and Sequence Analysis of the Human Acidic Fibroblast Growth Factor Gene and Its Preservation in Leukemia Patients.." Oncogene. Vol. 6, (January 1991.): 1521-1529.

Wang, WP, Myers, RL, Chiu, IM. "Single Primer-Mediated Polymerase Chain Reaction: Application in Cloning of Two Different 5'-Untranslated Sequences of Acidic Fibroblast Growth Factor mRNA." DNA Cell Biol.. Vol. 10, (January 1991.): 771-777.

Wang, WP, Chiu, IM. "A Sequence Tagged Site (STS) Detects EcoRI Polymorphisms in the Human Acidic Fibroblast Growth Factor Gene." Nucleic Acids Res.. Vol. 19, (January 1991.): 4563-.

Chiu, IM, Lehtoma, K, Poulin, ML. "Cloning of cDNA Inserts for Phage DNA Directly Into A Plasmid Vector." Methods Enzymol. Vol. 44, (January 1992.): 508-516.

Ernst, LK, van de Winkel, JGJ, Chiu, IM, Anderson, CL. "Three Genes for the Human High Affinity Fc Receptor for IgG (FcyRI) Encode Four Distinct Transcription Products." J. Biol. Chem.. Vol. 267, (January 1992.): 15692-15700.

Jhiang, SM, Caruso, DR, Gilmore, E, Ishizaka, Y, Tahira, T, Nagao, M, Chiu, IM, Mazzaferri, EL. "Detection of the PTC/ret tpc Oncogene in Human Thyroid Cancers." Oncogene. Vol. 7, (January 1992.): 1331-1337.

Myers, RL, Payson, RA, Chotani, MA, Deaven, LL, Chiu, IM. "Gene Structure and Differential Expression of Acidic Fibroblast Growth Factor mRNA: Identification and Distribution of Four Different Transcripts." Oncogene. Vol. 8, (January 1993.): 341-349.

Poulin, ML, Patrie, KM, Botelho, MJ, Tassava, RA, Chiu, IM. "Heterogeneity in the Expression of Fibroblast Growth Factor Receptors During Limb Regeneration in Newts (Notophthalmus viridescens)." Development. Vol. 119, (January 1993.): 353-361.

Payson, RA, Canatan, H, Chotani, MA, Wang, WP, Harris, SE, Myers, RL, Chiu, IM. "Cloning of Two Novel Forms of Human Acidic Fibroblast Growth Factor (aFGF) mRNA." Nucleic Acids Res.. Vol. 21, (January 1993.): 489-495.

Poulin, ML, Chiu, IM. "Nucleotide Sequences of Two Newt (Notophthalmus viridescens) Fibroblast Growth Factor Receptor-2 Variants." Biochim. Biophys. Acta. Vol. 1220, (January 1994.): 209-211.

Poulin, ML, Chiu, IM. "Direct Cloning of λgt11 cDNA Inserts Into a Plasmid Vector." Methods in Molecular Biology: Protocols for Gene Analysis. Vol. 31, (January 1994.): 9-18.

Chiu, IM, Gilmore, EC, Liu, Y, Payson, RA. "Construction of a Yeast Artificial Chromosome Contig Encompassing the Human Acidic Fibroblast Growth Factor (FGF1) Gene: Toward the Cloning of the ANLL/MDS Tumor-Suppressor Gene." Genomics. Vol. 19, (January 1994.): 552-560.

Myers, RL, Chiu, IM. "Single Primer-Mediated Polymerase Chain Reaction." Methods in Molecular Biology: Protocols for Gene Analysis. Vol. 31, (January 1994.): 307-315.

Voulgaropoulou, F, Myers, RM, Chiu, IM. "Alternative Splicing of FGF-1 Transcripts: A Cellular Dilemma in Detrmining Exon Selection and Exclusion." DNA Cell Biol.. Vol. 13, (January 1994.): 1001-1009.

Poulin, ML, Chiu, IM. "Re-Programming of Expression of the KGFR and bek Variants of Fibroblast Growth Factor Receptor 2 (FGFR2) During Limb Regeneration in Newts (Notophthalmus viridescens)." Dev. Dynamics. Vol. 202, (January 1995.): 378-387.

Myers, RL, Ray, S, Eldridge, R, Chotani, MA, Chiu, IM. "Functional Character-ization of the Brain-Specific FGF-1 Promoter, FGF-1.B." J. Biol. Chem.. Vol. 270, (January 1995.): 8257-8266.

Myers, RL, Chedid, M, Tronick, SR, Chiu, IM. "Different Fibroblast Growth Factor 1 (FGF-1) Transcripts in Neural Tissues, Glioblastomas and Kidney Carcinoma Cell Lines." Oncogene. Vol. 11, (January 1995.): 785-789.

Patrie, KM, Kudla, AJ, Olwin, BB, Chiu, IM. "Conservation of Ligand Specificity Between the Mammalian and Amphiban Fibroblast Growth Factor Receptors." J Biol. Chem.. Vol. 270, (January 1995.): 29018-29024.

Chiu, IM. "Human Fibroblast Growth Factor1 Gene Expression in Vascular Smooth Muscle Cells is Modulated via an Alternate Promoter in Response to Serum and Phorbol Ester." Nucl. Acids Res.. Vol. 23, (January 1995.): 434-441.

Madiai, F, Hackshaw, KV, Chiu, IM. "Cloning and Characterization of the Mouse FGF-1 Gene." Gene. Vol. 179, (January 1996.): 231-236.

Hackshaw, KV, Furlow, Z, Chiu, IM. "Cloning and Characterization of a Novel Upsteam Untranslated Exon of the Mouse FGF-1 Gene." Gene. Vol. 180, (January 1996.): 131-135.

Payson, RA, Wu, J, Liu, Y, Chiu, IM. "The Human FGF-8 Gene Localizes on Chromosome 10q24 and is Subjected to Induction by Androgen in Breast Cancer Cells." Oncogene. Vol. 13, (January 1996.): 47-53.

Alam, KY, Frostholm, A, Hackshaw, KV, Evans, JE, Rotter, A, Chiu, IM. "Characterization of the 1B Promoter of Fibroblast Growth Factor 1 and its Expression in the Adult and Developing Mouse Brain." J. Biol. Chem.. Vol. 271, (January 1996.): 30263-30271.

Chotani, MA, Chiu, IM. "A Recombinant PCR Approach Requiring Only Three Non-Chimeric Primers to Generate a Minigene of Interest." Genet. Anal.. Vol. 12, (January 1996.): 133-135.

Wu, J, Payson, RA, Lang, J, Chiu, IM. "Activation of Fibroblast Growth Factor 8 Gene Expression in Human Embryonal Carcinoma Cells." J Steroid Biochem. Mol. Biol.. Vol. 62, (January 1997.): 1-10.

Ray, SK, Yang, XQ, Chiu, IM. "Transcriptional Activation of Fibroblast Growth Factor 1.B Promoter is Mediated Through an 18-Base Pair cis-Acting Element." J. Biol. Chem.. Vol. 272, (January 1997.): 7546-7555.

del Rio-Tsonis, K, Jung, JC, Chiu, IM, Tsonis, PA. "Conservation of Fibroblast Growth Factor Function in Lens Regeneration." Proc. Natl. Acad. Sci. USA. Vol. 94, (January 1997.): 13701-13706.

Patrie, K, Botelho, MJ, Ray, SK, Mehta, V, Chiu, IM. "Amphibian FGF-1 is Structurally and Funtionally Similar to but Antigenically Distinguishable from its Mammalian Couterpart.." Growth Factors. Vol. 14, (January 1997.): 39-57.

Liu, Y, Chiu, IM. "Assignment of FGF12, the Human FGF Homologous Factor 1 Gene, to Chromosome 3q29�3qter by Fluorescence in situ Hybridization." Cytogenet. Cell Genet.. Vol. 78, (January 1997.): 48-49.

Poulin, ML, Botelho, MJ, Chiu, IM. "Cloning and Interspecies Comparison of Three Newt (Notophthalmus viridescens) Fibroblast Growth Factor Receptors Reveal High Conservation of this Receptor Family." Mol. Cell. Biochem.. Vol. 175, (January 1997.): 11-19.

Chotani, MA, Chiu, IM. "Differential Regulation of Human Fibroblast Growth Factor 1 Transcripts Provides a Distinct Mechanism of Cell-Specific Growth Factor Expression." Cell Growth Differ. Vol. 8, (January 1997.): 999-1013.

Chiu, IM. "A 720-kb Yeast Artificial Chromosome Contig Spanning Human Chromosome 5q31.3-32." Leukemia 11 Suppl. Vol. 3, (January 1997.): 303-306.

Mehta, VB, Wang, RHC, Connors, L, and Chiu, IM. "Fibroblast Variants Nonresponsive to FGF-1 are Defective in its Nuclear Translocation." J. Biol. Chem.. Vol. 273, (January 1998.): 4197-4205.

Payson, RA, Chotani, MA, Chiu, IM. "Regulation of a Promoter of the Fibroblast Growth Factor 1 Gene in Prostate and Breast Cancer Cells." J. Steroid Bochem. Mol. Biol.. Vol. 66, (January 1998.): 93-103.

McAndrew, PE, Frostholm, A, Evans, JE, Zdilar, D, Goldowitz, D, Chiu, IM, Burghes, AHM, Rotter, A. "Novel Receptor Protein Tyrosine Phosphatase (RPTP�) and Acidic Fibroblast Growth Factor (FGF-1) Transcripts Delineate a Rostrocaudal Boundary in the Granule Cell Layer of the Murine Cerebellar Cortex." J. Comp. Neurol.. Vol. 391, (January 1998.): 444-455.

Chiu, IM, Liu, Y, Payson, RA. "Isolation of Yeast Artificial Chormosomes Containing the Entire Transcriptional Unit of the Human FGF-1 Gene: A 720-kb Contig Spanning Human Chromosome 5q31.3-32." Cancer Genet. Cytogenet.. Vol. 106, (January 1998.): 1-10.

Liu, Y, Ray, SK, Yang, XQ, Luntz-Leybman, V, Chiu, IM. "A Splice Variant of E2-2 Basic Helix-Loop-Helix Protein Which Binds to an Imperfect E-Box Represses the Activity of an FGF-1 Promoter." J. Biol. Chem.. Vol. 273, (January 1998.): 19269-19276.

Madiai, F, Hackshaw, KV, Chiu, IM. "Characterization of the Entire Transcription Unit of the Mouse Fibroblast Growth Factor 1 (FGF-1) Gene." J. Biol. Chem.. Vol. 274, (January 1999.): 11937-11944.

Patrie, KM, Botelho, MJ, Franklin, K, Chiu, IM. "Site-Directed Mutagenesis and Molecular Modeling Idenifty a Crucial Amino Acid in Specifying the Heparin Affinity of FGF-1." Biochemistry. Vol. 38, (January 1999.): 9264-9272.

Chiu, IM, Touhalisky K, Liu Y, Yates, A, Frostholm A. "Tumorigenesis in Transgenic Mice in Which the SV40 T-Antigen is Driven by the Brain Specific FGF-1 Promoter." Oncogene. Vol. 19, (January 2000.): 6229-6239.

Chotani, MA, Touhalisky, K, Chiu, IM. "The Small GTPases Ras, Rac and Cdc42 Transcriptionally Regulate Expression of Human Fibroblast Growth Factor 1." J. Biol. Chem.. Vol. 275, (January 2000.): 30432-30438.

Cho, JY, Xing, S, Liu, X, Buckwalter, TLF, HWA, L, Sferra, TJ, Chiu, IM, Jhiang, SM. "Expression and Activity of Human Na+/I- Symporter in Human Glioma Cells by Adenovirus-Mediated Gene Delivery." Gene. Ther.. Vol. 7, (January 2000.): 740-749.

Chi, YH, Kumar, TKS, Chiu, IM, Yu, C. "15N NMR Relaxation Studies of Free and Ligand Bound Human Acidic Fibroblast Growth Factor." J. Biol. Chem.. Vol. 275, (January 2000.): 39444-39450.

Arunkumar, AI, Srisailman, S, Kumar, TKS, Kathir, KM, Peng, CL, Chen, C, Chiu, IM, and Yu, C. "1H, 13C and 15N Chemical Shift Assignments of the Acidic Fibroblast Growth Factor from Notophthalmus viridescens." J. Biomol.NMR. Vol. 17, (January 2000.): 279-280.

Chiu, IM, Touhalisky, K, Baran, C. "Multiple Controlling Mechanisms of FGF1 Gene Expression Through Multiple Tissue-Specific Promoters." Prog. Nucleic Acid Res. Mol. Biol.. Vol. 70, (January 2001.): 155-174.

Chi, YH, Kumar, TKS, Wang, HM, Ho, MC, Chiu, IM, Yu, C. "Thermodynamic Characterization of the Human Acidic Fibroblast Growth Factor: Evidence for Cold Denaturation." Biochemistry. Vol. 40, (January 2001.): 7746-7753.

Arunkumar, AI, Srisailam, S, Kumar, TK, Kathir, KM, Chi, YH, Wang, HM, Chang, GG, Chiu, IM, Yu, C. "Structure and Stability of an Acidic Fibroblast Growth Factor from Notophthalmus viridescens." J. Biol. Chem.. Vol. 277, (January 2002.): 46424-46432.

Arunkumar, AI, Kumar, TKS, Kathir, KM, Srisailam, S, Wang, HM, Leena, PS, Chi, YH, Chen, HC, Wu, CH, Wu, RT, Chang, GG, Chiu, IM, Yu, C. "Oligomerization of Acidic Fibroblast Growth Factor is Not a Prerequisite for Its Cell Proliferation Activity." Protein Sci.. Vol. 11, (January 2002.): 1050-1061.

Weiss, WA, Israel, M, Cobbs, C, Holland, E, James, CD, Louis, DN, Marks, C, McClatchey, AI, Roberts, T, Van Dyke, T, Wetmore, C, Chiu, IM, Giovannini, M, Guha, A, Higgins, RJ, Marino, S, Radovanovic, I, Reilly, K, Aldape, K. "Neuropathology of Genetically Engineered Mice: Consensus Report and Recommendations from an International Forum." Oncogene. Vol. 21, (January 2002.): 7453-7463.

Srimathi, T, Kumar, TK, Chi, YH, Chiu, IM, Yu, C. "Characterization of the Structure and Dynamics of a Near-Native Equilibrium Intermediate in the Unfolding Pathway of an All β-barrel Protein.." J. Biol. Chem.. Vol. 277, (January 2002.): 47507-47516.

Dungan, KM, Wei, TY, Nace, JD, Poulin, ML, Chiu, IM, Lang, JC, Tassava, RA. "Expression and Biological Effect of Urodele Fibroblast Growth Factor1: Relationship to Limb Regeneration." J. Exp. Zool. Vol. 292, (January 2002.): 540-554.

Chi, YH, Kumar, TK, Kathir, KM, Lin, DH, Zhu, G, Chiu, IM, Yu, C. "Investigation of the Structural Stability of the Human Acidic Fibroblast Growth Factor by Hydorgen-Deuterium Exchange." Biochemistry. Vol. 41, (January 2002.): 15350-15359.

Chi, YH, Kumar, TK, Chiu, IM, Yu C. "Identification of Rare Partially Unfolded States in Equilibrium with the Native Conformation in an All Beta-Barrel Protein." J. Biol. Chem.. Vol. 277, (January 2002.): 34941-34948.

Chiu, CN, Mitra, R, Chiu, IM. "Exchange of Genetic Sequences of Long Terminal Repeat and env Gene by a Promiscuous Primate Type D Retrovirus." Virus Res.. Vol. 96, (January 2003.): 107-111.

Srimathi, T, Kumar, TK, Kathir, KM, Chi, YH, Srisailam, S, Lin, WY, Chiu, IM, Yu, C. "Structurally Homologous All Beta-Barrel Proteins Adopt Different Mechanisms of Folding." Biophys. J.. Vol. 85, (January 2003.): 459-472.

Liu, YP, Burleigh, D, Durning, M, Hudson, L, Chiu, IM, Golos, TG. "Id2 is a Primary Partner for the E2-2 Basic Helix-Loop-Helix Transcription Factor in the Human Placenta." Mol. Cell. Endocrinol.. Vol. 222, (January 2004.): 83-91.

Martineau, Y, Le Bec, C, Monbrun, L, Allo, V, Chiu, IM, Danos, O, Moine, H, Prats, H, Prats, AC. "Internal Ribosome Entry Site Structural Motifs Conserved Among Mammalian Fibroblast Growth Factor 1 Alternatively Spliced mRNAs." Mol. Cell. Biol.. Vol. 24, (January 2004.): 7622-7635.

Hung, KW, Kumar, TK, Chi, YH, Chiu, IM, Yu, C. "Molecular Cloning, Overexpression, and Characterization of the Ligand-Binding D2 Domain of Fibroblast Growth Factor Receptor." Biochem. Biophys. Res. Commun.. Vol. 317, (January 2004.): 253-258.

Hung, KW, Kumar, TK, Kathir, KM, Xu, P, Ni, F, Ji, HH, CHen, MC, Yang, CC, Lin, FP, Chiu, IM, Yu, C. "Solution Structure of the Ligand Binding Domain of the Fibroblast Growth Factor Receptor-Role of Heparin in the Activation of the Receptor.." Biochemistry. Vol. 44, (January 2005.): 15787-15798.

Hsiue, GH, Sung, HW, Hsu, SH, Huang, LLH, Lin, FH, Tsai, RJF, Chiu, IM. "Current Research Activity in Tissue Engineering and Regenerative Medicine in Taiwan." Regenerative Med.. Vol. 4, (January 2005.): 100-105.

Yen, ML, Chien, CC, Chiu, IM, Huang, HI, Chen, YC, Hu, HI, Yen, BL. "Multilineage Differentiation and Characterization of the Human Fetal Osteoblastic 1.19 (hFOB) Cell Line: A Possible in Vitro Model of Human Mesenchymal Progenitors." Stem. Cells. Vol. 25, (January 2007.): 125-131.

Hsu, YC, Lee, DC, Chiu, IM. "Neural Stem Cells, Neural Progenitors and Neuotrophic Factors." Cell Transplant. Vol. 16, (January 2007.): 133-150.

Lin, YL, Hen, JC, Hsu, SH, Chiu, IM. "Sciatic Nerve Repair by Microgrooved Nerve Conduits Made of Chitosan-Gold Nanocomposites." Surgical Neurol.. Vol. 70S1, (January 2008.): 9-S.

Hsu, YC, Lee, YC, Chen, SL, Liao, WC, Lin, JW, Chiu, WT, Chiu, IM. "Brain-Specific 1B Promoter for FGF1 Gene Facilitates the Isolation of Neural Stem/Progenitor Cells with Self-Renewal and Multipotent Capacities." Dev. Dyn.. Vol. 238, (January 2009.): 302-314.

Hsu, SH, Su, CH, Chiu, IM. "A Novel Approach to Align Adult Neural Stem Cells on Micropatterned Conduits for Peripheral Nerve Regeneration: a Feasibility Study." Artificial Organs. Vol. 33, (January 2009.): 26-35.

Lee, DC, Hsu, YC, Chung, YF, Hsiao, CY, Chen, SL, Chen, MS, Lin, HK, Chiu, IM. "Isolation of Neural Stem/Progenitor Cells by Using EGF/FGF1 and FGF1B Promoter-Driven Green Fluorescence from Empbryonic and Adult Mouse Brains." Mol. Cell. Neurosci. Vol. 41, (January 2009.): 348-363.

Lin, WF, Chen, CJ, Chang, YJ, Chen, SL, Chiu, IM, Chen, LY. "SH2B1β Enhances Fibroblast Growth Factor 1 (FGF1)-Induced Neurite Outgrowth Through MEK-ERK1/2-STAT3-Egr1 Pathway." Cell Signal. Vol. 21, (January 2009.): 1060-1072.

Chen, YC, Lee, DC, Hsiao, CY, Chung, YF, Chen, HC, Palathinkal, TJ, Pong, WF, Tai, NH, Lin, IN, Chiu, IM. "The Effect of Ultra-Nanocrystalline Diamond Films on the Proliferation and Differentiation of Neural Stem Cells." Biomaterials. Vol. 30, (January 2009.): 3428-3435.

Chen, JH, Wu, KY, Chiu, IM, Tsou, TC, Chou, CC. "Acrylamide-Induced Astrogliotic and Apoptotic Responses in Human Astrocytoma Cells." Toxicol In Vitro. Vol. 23, (January 2009.): 855-861.

Ni, HC, Lin, ZY, Hsu, SH, Chiu, IM. "The Use of Air Plasma in Surface Modification of Peripheral Nerve Conduits." Acta Biomater. Vol. 6, (January 2010.): 2066-2076.

Hsu, YC, Liao, WC, Kao, CY, Chiu, IM. "Regulation of FGF1 Gene Promoter Through Transcription Factor RFX1." J. Biol. Chem.. Vol. 285, (January 2010.): 13885-13895.

Chen, YC, Lee, DC, Tsai, TY, Hsiao, CY, Liu, JW, Kao, CY, Lin, HK, Chen, HC, Palathinkal, TJ, Pong, WF, Tai, NH, Lin, IN, Chiu, IM. "Induction and Regulation of Differentiation in Neural Stem Cells on Ultra-Nanocrystalline Damond Films." Biomaterials. Vol. 31, (January 2010.): 5575-5587.

Chen, CW, Liu, CS, Chiu, IM, Shen, SC, Pan, HC, Lee, KH, Lin, SZ, Su, HL. "The Signals of FGFs on the Neurogenesis of Embryonic Stem Cells." J. Biomed. Sci.. Vol. 17, no. 1. (January 2010.): 33-.

 

Inventions and Patents

Chiu, IM. "Isolated Nucleic Acid Encoding a New Acidic Fibroblast Growth Factor (AFGF)."

Chiu, IM. "Murine Cell Lines Which Over Produce Acidic Fibroblast Growth Factor (AFGF) and Method of Using Same."

Chiu, IM. ""DNA Construct Comprising an FGF1B Promoter Region Operable Linked to an SV40 Large T Antigen Encoding Sequence."

Chiu, IM. "Transgenic Animal for Screening Therapeutic Agents for Brain Tumors."

Chiu, IM. ""Transgenic Animal for Screnning Therapeutic Agents for Brain Tumors"."

Chiu, IM. "??????DNA??????????????????; "DNA Construct Comprising Transgene and Method for Obtaining Neural Stem Cells from Animal Cells"."

Chiu, IM. "Implantable Nerve Regeneration Conduit." Filed June 2009.

Chiu, IM. ""F1B-TMIR Plasmid Vector and Transgenic Mouse"." Filed July 2009.

Chiu, IM. "Divisional Application of "Methods of Obtaining Neural Stem Cells"." Filed February 2010.

Chiu, IM. "Improving the Expanison and Differentiation of Neural Stem Cells Through Utilizing Ultra-Nanocrystalline Diamond Films." Filed October 2009.

Chiu, IM. "????????????????????????; "Improving the Expanison and Differentiation of Neural Stem Cells Through Utilizing Ultra-Nanocrystalline Diamond Films"." Filed October 2009.

Chiu, IM. "?????????????????; "Transgenic Animal for Screening Therapeutic Agents for Bain Tumors"."

Chiu, IM. "??????????; Implantable Nerve Regeneration Conduit." Filed October 2008.