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Tim Eubank, PhD

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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-9958

Email: eubank.5@osu.edu


Postdoctoral / Researcher Advising

Duaa Dakhlallah, post-doctoral fellow, was awarded her fellowship for 2013-2014 on the Oncology T32 training grant led by Dr. Mike Caligiuri for her work on the regulation of tumor suppressor gene expression in breast cancer by tumor macrophages via microvesicle release.

Noteworthy Graduate Narrative

Tyler Nelson (BME) in the laboratory of John Lannutti was awarded a 2013 Pelotonia Fellowship Award for 2013-2014.

Academic Advising

2012 - present Nathanial Hogrebe The Ohio State University.
2012 - present Tyler Nelson The Ohio State University.
2012 - present Hsiu-Wan Meng The Ohio State University.
2013 - present Ming Chien The Ohio State University.
2013 - present Lamees Alssum The Ohio State University.
2013 - present T32 Mentor The Ohio State University.
2013 - present Alisa Blazek The Ohio State University.
2009 - 2012 Mary Forget The Ohio State University. Graduated 2012.
2010 - 2012 Connie Lee, The Ohio State University. Graduated 2012.
2011 - 2013 Mariana Gil The Ohio State University. Graduated 2013.

Chapters in Books

Eubank TD and Marsh CB. "Cytokines and Growth Factors in the Regulation of Wound Healing." In Wound Healing Society Yearbook Series: The Benchmark Interdisciplinary Digest for a Broad Readership - from Clinicians to Graduate Students. Vol. 1. Edited by Chandan Sen, PhD. -. New Rochelle, NY, US|USA: Mary Ann Liebert, Inc. Publishers, January 2009.

Roda, JM, Eubank, TD. "The Cellular Component of Chronic Inflammation." In Wound Healing Society Yearbook: Advances in Wound Care. Edited by Roy, S, Bagchi, D, Raychaudhuri, SP. -. Boca Raton, FL: CRC Pres, Taylor and Francis Group, December 2012.



1989 None Indicated, University Of Dayton

2003 Ph.D., The Ohio State University


Editorial Activities

2011 - present Wound Healing Society Year Book, Advances in Wound Care
2011 Breast Cancer Research and Treatment
2012 - present Journal of Cellular and Molecular Medicine
2012 - 2013 Public Library of Science (PLoS ONE)
2012 - 2014 International Journal of Cancer
2013 Journal of Immunology
2013 Brain, Behavior, and Immunity
2013 BMC Medicine
2014 - present Acta Biochimica et Biophysica Sinica
2014 - present The Anatolian Journal of Cardiology
2014 Cardiovascular Research


2005 - present Distinguished Post-Doctoral Researcher of the Year. Davis Heart & Lung Research Institute.
2006 - present Chief Post-doctoral Fellow. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine.
2007 - present Outstanding Poster Presentation, Faculty/Research Scientist Division, 2nd Annual Pulmonary Research Day. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine.
2009 - present Outstanding Research Poster. 22nd Annual Symposium on Advanced Wound Care and Wound Healing Society Meeting, Dallas TX.

Journal Articles

Eubank,T,D; Biswas,R; Jovanovic,M; Litovchick,A; Lapidot,A; Gopalan,V. "Inhibition of bacterial RNase P by aminoglycoside-arginine conjugates." FEBS Letters. Vol. 511, no. 1-3. (January 2002.): 107-112.

Eubank,T,D; Galloway,M; Montague,C,M; Waldman,W,J; Marsh,C,B. "M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes." JOURNAL OF IMMUNOLOGY. Vol. 171, no. 5. (September 2003.): 2637-2643.

Eubank,T,D; Roberts,R; Galloway,M; Wang,Y,J; Cohn,D,E; Marsh,C,B. "GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice." Immunity. Vol. 21, no. 6. (December 2004.): 831-842.

Yang EV, Sood AK, Chen M, Yeh P, Eubank TD, Marsh CB, Jewell S, Flavahan NA, Morrison C, Glaser R.. "Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells." Cancer Research. Vol. 66, no. 21. (November 2006.): 10357-10364.

Wang, Y, Zeigler, MM, Lam, GK, Hunter, MG, Eubank, TD, Khramtsov, VV, Tridandapani, S, Sen, CK, Marsh, CB. "The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 36, no. 1. (January 2007.): 68-77.

Parinandi, NL, Sharma, A, Eubank, TD, Kaufman, BF, Kutala, VK, Marsh, CB, Ignarro, LJ, Kuppusamy, P. "Nitroaspirin (NCX-4016), an NO donor, is Antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells." ANTIOXIDANTS & REDOX SIGNALING. Vol. 9, no. 11. (November 2007.): 1837-1849.

Bringardner, BD, Baran, CP, Eubank, TD, Marsh, CB. "The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis." ANTIOXIDANTS & REDOX SIGNALING. Vol. 10, no. 2. (February 2008.): 287-301.

Curry, JM, Eubank, TD, Roberts, RD, Wang, Y, Pore, N, Maity, A, Marsh, CB. "M-CSF Signals through the MAPK/ERK Pathway via Sp1 to Induce VEGF Production and Induces Angiogenesis In Vivo." PLoS ONE. Vol. 3, no. 10. (October 2008.): e3405-.

Ali, NA, Gaughan, AA, Orosz, CG, Baran, CP, McMaken, S, Wang, Y, Eubank, TD, Hunter, M, Lichtenberger, FJ, Flavahan, NA, Lawler, J, Marsh, CB. "Latency Associated Peptide Has In Vitro and In Vivo Immune Effects Independent of TGF-beta 1." PLoS ONE. Vol. 3, no. 4. (April 2008.): e1914-.

Hunter, M, Wang, Y, Eubank, T, Baran, C, Nana-Sinkam, P, Marsh, C. "Survival of monocytes and macrophages and their role in health and disease." FRONTIERS IN BIOSCIENCE-LANDMARK. Vol. 14, (January 2009.): 4079-4102.

Eubank, TD, Roberts, RD, Khan, M, Curry, JM, Nuovo,GJ, Kuppusamyl, P, Marsh, CB. "Granulocyte Macrophage Colony-Stimulating Factor Inhibits Breast Cancer Growth and Metastasis by Invoking an Anti-Angiogenic Program in Tumor-Educated Macrophages." Cancer Research. Vol. 69, no. 5. (March 2009.): 2133-2140.

Bobko, AA, Dhimitruka, I, Eubank, TD, Marsh, CB, Zweier, JL, Khramtsov, VV. "Trityl-based EPR probe with enhanced sensitivity to oxygen." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 47, no. 5. (September 2009.): 654-658.

HO,W; Eubank,T; Leblebicioglu,B; Marsh,C; Walters,J. "Azithromycin Decreases Crevicular Fluid Volume and Mediator Content." JOURNAL OF DENTAL RESEARCH. Vol. 89, no. 8. (August 2010.): 831-835.

Sliman, SM, Eubank, TD, Kotha, SR, Kuppusamy, ML, Sherwani, SI, Butler, E, O'Connor, S, Kuppusamy, P, Roy, , Marsh,C CB, Stern, DM, Parinandi, N,L. "Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection." MOLECULAR AND CELLULAR BIOCHEMISTRY. Vol. 333, no. 1-2. (January 2010.): 9-26.

Parihar A, Eubank TD, Doseff AI. "Monocytes and Macrophages regulate immunity through dynamic networks of survival and cell death.." Journal of Innate Immunity. Vol. 3, no. 2. (January 2010.): 204-215.

Eubank, TD, Roda,Ju JM, Liu, H, O'Neil, T, Marsh, CB. "Opposing roles for HIF-1 alpha and HIF-2 alpha in the regulation of angiogenesis by mononuclear phagocytes." Blood. Vol. 117, no. 1. (January 2011.): 323-332.

Mehta, P, Wavreille, AS, Justiniano, SE, Marsh, RL, Yu, J, Burry, RW, Jarjoura, D, Eubank, T, Caligiuri, MA, Butchar,JP, Tridandapani, S. "LyGDI, a Novel SHIP-Interacting Protein, Is a Negative Regulator of Fc gamma R-Mediated Phagocytosis." PLOS ONE. Vol. 6, no. 6. (June 2011.): e21175-.

Roda, JM, Sumner, LA, Evans,R, Phillips, GS, Marsh, CB, Eubank, TD. "Hypoxia-Inducible Factor-2 alpha Regulates GM-CSF-Derived Soluble Vascular Endothelial Growth Factor Receptor 1 Production from Macrophages and Inhibits Tumor Growth and Angiogenesis." JOURNAL OF IMMUNOLOGY. Vol. 187, no. 4. (August 2011.): 1970-1976.

Eubank, TD, and Marsh, CB. "HIF: A-Cute Answer for Inflammation?." Blood. Vol. 118, (July 2011.): 485-487.

Bobko, AA, Eubank,TD, Voorhees,J JL, Efimova, OV, Kirilyuk,IA, Petryakov, S, Trofimiov, DG, Marsh, CB, Zweier, JL, Grigor'ev, IA, Samouilov, A, Khramtsov, VV. "In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors." MAGNETIC RESONANCE IN MEDICINE. Vol. 67, no. 6. (June 2012.): 1827-1836.

Roda, JM, Wang, Y, Sumner, LA, Phillips, GS, Marsh, CB, Eubank, TD. "Stabilization of HIF-2 alpha Induces sVEGFR-1 Production from Tumor-Associated Macrophages and Decreases Tumor Growth in a Murine Melanoma Model." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 6. (September 2012.): 3168-3177.

Chen, D, Roda,J JM, Marsh, CB, Eubank, TD, Friedman, A. "Hypoxia Inducible Factors-Mediated Inhibition of Cancer by GM-CSF: A Mathematical Model." BULLETIN OF MATHEMATICAL BIOLOGY. Vol. 74, no. 11. (November 2012.): 2752-2777.

Szomolay B, Eubank TD, Roberts RD, Marsh CB, Friedman A. "Inhibition of breast cancer by GM-CSF: A mathematical model." Journal of Applied Mathematics. Vol. 303, (June 2012.): 1-151.

Yang, EV, Eubank, TD. "The impact of adrenergic signaling in skin cancer progression: Possible repurposing of beta-blockers for treatment of skin cancer." CANCER BIOMARKERS. Vol. 13, no. 3. (January 2013.): 155-160.

Emecen-Huja, P, Eubank,TD, Shapiro, V, Yildiz, V, Tatakis, D,N, Leblebicioglu, B. "Peri-implant versus periodontal wound healing." JOURNAL OF CLINICAL PERIODONTOLOGY. Vol. 40, no. 8. (August 2013.): 816-824.

Dhimitruka, I, Bobko, AA, Eubank, TD, Komarov, DA, Khramtsov, VV. "Phosphonated Trityl Probes for Concurrent in Vivo Tissue Oxygen and pH Monitoring Using Electron Paramagnetic Resonance-Based Techniques." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Vol. 135, no. 15. (April 2013.): 5904-5910.

Voorhees, JL, Tarr, AJ, Wohleb, ES, Godbout, JP, Mo, X, Sheridan, JF, Eubank, TD, Marsh, CB. "Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10." PLOS ONE. Vol. 8, no. 3. (March 2013.): e58488-.

Justiniano SE, Elavazhagan S, Fatehchand K, Shah P, Mehta P, Roda JM, Mo X, Cheney C, Hertlein E, Eubank TD, Marsh C, Muthusamy N, Butchar JP, Byrd JC, Tridandapani S.. "Fcγ Receptor-induced Soluble Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Production Inhibits Angiogenesis and Enhances Efficacy of Anti-tumor Antibodies." J Biol Chem. Vol. 13, (September 2013.): 26800-268009.

Voorhees JL, Powell ND, Moldovan L, Mo X, Eubank TD, Marsh CB.. "Chronic Restraint Stress Upregulates Erythropoiesis Through Glucocorticoid Stimulation." PLoS ONE. Vol. 8, (October 2013.): e77935-.

Mackos, AR, Eubank,TD, Parry NMA, Bailey, MT. "Probiotic Lactobacillus reuteri Attenuates the Stressor-Enhanced Severity of Citrobacter rodentium Infection." INFECTION AND IMMUNITY. Vol. 81, no. 9. (September 2013.): 3253-3263.

Ismail, N, Wang, Y, Dakhlallah, D, Moldovan, L, Agarwal, K, Batte, K Shah, P, Wisler, J, Eubank, TD, Tridandapani,S, Paulaitis, ME, Piper, MG, Marsh, CB. "Macrophage microvesicles induce macrophage differentiation and miR-223 transfer." BLOOD. Vol. 121, no. 6. (February 2013.): 984-995.

Mace, TA, Ameen, Z, Collins, A, Wojcik, S, Mair, M, Young, GS, Fuchs, JR, Eubank, TD, Frankel, WL, Bekaii-Saab, T, Bloomston, M, Lesinski, GB. "Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner." Cancer Research. Vol. 73, no. 10. (May 2013.): 3007-3018.

Sherwani SI, Aldana C, Usmani S, Adin C, Kotha S, Khan M, Eubank T, Scherer P, Parinandi N, Magalang UJ.. "Intermittent Hypoxia Exacerbates Pancreatic β-cell Dysfunction In A Mouse Model of Diabetes Mellitus." Sleep. Vol. 36, no. 12. (December 2013.): 1849-58.

Martin-Vaquero, Paula, da Costa, Ronaldo, Moore, Sarah, Gross, Amy, Eubank, Tim. "Cytokine Concentrations in the Cerebrospinal Fluid of Great Danes with Cervical Spondylomyelopathy." Journal of Veterinary Internal Medicine. Vol. 28, no. 4. (June 2014.): 1268-74.

Samouilov, A, Efimova, OV, Bobko, AA, Sun, Z, Petryakov, S, Eubank, TD, Trofimov, DG, Kirilyuk, IA, Grigor'ev, IA, Takahashi, W, Zweier, JL, Khramtsov, VV. "In vivo proton-electron double-resonance imaging of extracellular tumor pH using an advanced nitroxide probe." Analytical Chemistry. Vol. Jan 21;86(2), (January 2014.): 1045-52.

Forget, MA, Voorhees, JL, Cole, SL, Dakhlallah D, Patterson, IL, Gross, AC, Moldovan, L, Mo, X, Evans, R, Marsh, CB, Eubank, TD.. "Macrophage colony-stimulating factor augments tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer.." PLoS ONE. Vol. Jun 3;9(6), (June 2014.): e98623-.

Eubank, TD. "A sympathetic role for the pancreas in tumor progression?." Brain Behavior and Immunity. Vol. S0889-1591(14), (May 2014.): 00124-X.

Chen, D, Bobko, AA, Gross, AC, Evans, R, Marsh, CB, Khramtsov, VV, Eubank, TD, Friedman, A.. "Involvement of Tumor Macrophage HIFs in Chemotherapy Effectiveness: Mathematical Modeling of Oxygen, pH, and Glutathione.." PLoS ONE. Vol. 9, no. 10. (October 2014.): eCollection 2014-.


Reference Works

Magalang, UJ, Das, AM, Sherwani, SI, Needleman, B, Mikami, D, Teodorescu, M, Suzo, A, Scherer, P, Eubank, TD, Parinandi, N."Fibrosis and Sleep Apnea" .

Inventions and Patents

Eubank, TD, Marsh, CB, Dakhlallah, D. "Compositions and Methods for Modulating DNA Methylation." The Ohio State University. Filed August 2013.

Eubank, TD, Roda, J, Marsh, CB. "Methods for Stabilizing Hypoxia Inducible Factor-2a as a Method for Treating Cancer." The Ohio State University. Filed June 2012.



"The Effects of GM-CSF on Breast Cancer Growth and Metastasis." Presented at 4th Annual Division of Pulmonary Medicine Research Day, Columbus, Ohio. (September 2009)

"Chrondomodulin-1: A Potential Link to Psychological Stress and Human Breast Cancer Progression." Presented at Institute for Behavioral Medicine Research (IBMR) Stress and Cancer Biology Interest Group, Columbus, Ohio. (May 2011)

"Chrondomodulin-1: A Molecular Link to Psychological Stress and Human Breast Cancer Progression?." Presented at Division of Pulmonary Medicine - Research in Progress, Columbus, Ohio. (May 2011)

"CCL2 Down-regulation from Macrophages by Stress-induced Norepinephrine Inhibits Tumor Growth in a Model of Malignant Melanoma." Presented at Davis Heart & Lung Research Institute Administration Meeting, Columbus, Ohio. (August 2011)

"Longitudinal Study for Serum Biomarker Prediction of Wound Healing in Diabetic Patients." Presented at Invited speaker, Translational to Clinical (T2C) Regenerative Medicine Wound Care International Conference, Columbus, Ohio. (March 2012)

"Stabilizing HIF-2alpha as a Method for Treating Cancer." Presented at Davis Heart & Lung Research Institute Research Day, Columbus, Ohio. (October 2012)

"Elucidating the Role of HIF-2alpha in Regulating Melanoma Growth and Angiogenesis." Presented at Davis Heart & Lung Research Institute Research in Progress, Grant Review, Columbus, Ohio. (January 2012)

"The Disparate Role of Mononuclear Phagocytes in Solid Tumor Progression." Presented at Graduate Student Seminar Series, OSU College of Medicine, Columbus, Ohio. (November 2013)

"Macrophage phenotype drives tumor program via epigenetic machinery carried in secreted microvesicles." Presented at AACR Cellular Heterogeneity in the Tumor Microenvironment, San Diego, CA. (February 2014)

"Regulation of Tumor Angiogenesis by Tie2-Expressing Monocytes." Presented at DHLRI Research in Progress - Grant Review, Ohio. (September 2014)


Professional Activities

present Study Section for the 2014 ACS/OSU Institutional Research Grants. The Ohio State University Medical Center.
present Grant reviewer for CCTS Intramural Track Funding. CCTS.
present Grant Reviewer. MEDIC.
present Study Section for the 2012 ACS/OSU Institutional Research Grants. The Ohio State University Medical Center.
present Judging Panel for the 2009 TechColumbus Innovation Awards.
2012 - present Adviser for Cameron Marsh.
2013 - present Adviser for Sarah McMaken.
2013 - present Advisor for Tierra Ware.
2013 - present Advisor for Leni Moldovan.
2013 - present Co-Research Advisor for Ivory Patterson.
2014 - present Research Adviser for Walker Caldwell.
2014 - present Research Adviser for Mark Lampert.
2014 - present Research Adviser for Tyler Williford.
2014 - present 2014 OSU Comprehensive Cancer Center Intramural Research Basic Science Program. OSUCCC.
2005 Advisor for Todd O'Neil.
2006 Advisor for Nworah Ayogu.
2006 Advisor for Nikki H. Liu.
2005 - 2008 Division of Pulmonary Medicine Scientific Illustrator.
2007 - 2008 Advisor for Dave Schreiber.
2005 - 2009 Co-Research Advisor for Jennifer Curry.
2005 - 2009 Co-Research Advisor for Ryan Roberts.
2007 - 2011 Co-Research Advisor for Julie Roda.
2011 Advisor for Nisha Crouser.
2008 - 2012 Co-Research Advisor for Jeff Voorhees.
2011 - 2013 Study Section for the CCTS Davis Bremer Awards. CCTS Davis Bremer Awards.

Unpublished Works

Chen, D, Bobko, A, Khramtsov, VV, Eubank, TD, Friedman, A. (Tentative) Tumor Microenvironmental Parameters Driving Successful Chemotherapy in Breast Cancer.

Nam J, Blazek AD, Perera P, Gordon R, Kim DG, Kwon HJ, Jeong YH, Wu LC, Sun Z, Knapik D, Leblebicioglue B, Hackshaw K, Phieffer L, Litsky AS, Liu S, Schneyer AL, Butterfield TA, Lee BS, Weisleder NL, Eubank TD, Agarwal S. Follistatin-like 3 mediates exercise-driven bone formation. October 2013.

Eubank TD (1st and co-corresponding author), Marsh CB, Bailey MT, Gross AC, Sumner LA, Voorhees J, Morrison KR, Crouser N, Curry JM, Wang Y, Phillips GS, Glaser R, Yang EV. CCL2 Down-regulation from Macrophages by Stress-induced Norepinephrine Inhibits Tumor Growth in a Model of Malignant Melanoma.

Forget M, Mo X, Evans R, Gross A, Moldovan L, Cole, S, Eubank TD, Marsh CB.. HIF-1a, but not HIF-2a, Regulates the Tie2 Receptor on Tie2-Expressing Monocytes in PyMT Breast Tumors and Augments Angiogenic Function and Metastases. April 2013.

Woldman YY, Eubank TD, Varadharajb S, Gavrilinb MA, Branchinic BR, Khramtsov VV. Detection of Nitric Oxide Production in Cell Cultures by Novel Chemiluminescent Method. July 2013.

Galley JD, Mackos AR, Eubank TD, Easterling RM, Parry NM, Fox JG, Lyte M, and Bailey, MT. Lactobacillus reuteri attenuates the exacerbating effects of stressor exposure on Citrobacter rodentium-induced colitis. September 2013.

Gurney TO, Kotha SR, Sliman S, Rao L, Shelton AB, Eubank TD, Parinanid NL.. Dimeracaptosuccinate protects against hyperglycemic oxoaldehyde-induced vascular endothelial damage: Role of iron and redox alterations in diabetic vascular dysfunction. October 2013.