Susheela Tridandapani, PhD

Current OSU Appointments

Professor, Pulm,Allergy,Crit Care & Sleep

Professor, SBS-Microbial Infectn/Immunity

Biographical

Dr. Susheela Tridandapani is a Professor of Internal Medicine and Co-Director of Research in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine. She obtained her PhD in 1998, following which she pursued postdoctoral work at Harvard University and at the Ohio State University. She was appointed to the Faculty in Internal Medicine in 2002. Dr. Tridandapani has a fully funded (NIAID, NCI) research program examining the molecular mechanisms of innate immune responses to bacterial pathogens and IgG-immune complexes, particularly in the context of monoclonal antibody therapy for cancer. She has trained and continues to train numerous graduate students and postdoctoral fellows who have successfully competed for prestigious fellowships from NIH, AHA and ACS. She currently serves as the Co-Director of the Lung Inflammation T32 Program.

Chapters in Books

Tridandapani S, CL Anderson. "Regulation of FcyR-Mediated Phagocytosis by FcyRIIb and Phosphatases." In Molecular Mechanisms of Phagocytosis. -. January 2005.

Journal Articles

Tridandapani S, Smith JL, Lyden TW, Coggeshall KM, CL Anderson. "Linker for activation of T cells (LAT) supports Fcy receptor-mediated signal transduction in myeloid cells." J. Biol. Chem. Vol. 275(27), (January 2000.): 20480-.

Lyden TW, Robinson JM, Tridandapani S, Teillaud J-L, Garber S, Osborn JM, Frey J, CL Anderson. "The IgG receptor expressed in placental endothelial cells is FcyRIIb2." J. Immunol.. Vol. 166, (January 2001.): 3882-.

Parihar R, Trotta R, Roda JM, Ferketich AK, Tridandapani S, Caligiuri MA, WE Carson. "SHIP1 negatively regulates cytokine production by NK cells stimulated with antibody-coated tumor cells and IL-12." Cancer Research. Vol. 65, (January 2005.): 9099-9107.

Henning,Lisa,N; Azad,Abul,K; Parsa,Kishore,VL; Crowther,Joy,E; Tridandapani,Susheela; Schlesinger,Larry,S. "Pulmonary surfactant protein a regulates TLR expression and activity in human macrophages." JOURNAL OF IMMUNOLOGY. Vol. 180, no. 12. (June 2008.): 7847-7858.

Lapalombella,Rosa; Yu,Bo; Triantafillou,Georgia; Liu,Qing; Butchar,Jonathan,P; Lozanski,Gerard; Ramanunni,Asha; Smith,Lisa,L; Blum,William; Andritsos,Leslie; Wang,Da-Sheng; Lehman,Amy; Chen,Ching-Shih; Johnson,Amy,J; Marcucci,Guido; Lee,Robert,J; Lee,L,James; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells." BLOOD. Vol. 112, no. 13. (December 2008.): 5180-5189.

Parsa,Kishore,VL; Butchar,Jonathan,P; Rajaram,Murugesan,VS; Cremer,Thomas,J; Gunn,John,S; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFN gamma response." MOLECULAR IMMUNOLOGY. Vol. 45, no. 12. (July 2008.): 3428-3437.

Butchar,Jonathan,P; Cremer,Thomas,J; Clay,Corey,D; Gavrilin,Mikhail,A; Wewers,Mark,D; Marsh,Clay,B; Schlesinger,Larry,S; Tridandapani,Susheela. "Microarray Analysis of Human Monocytes Infected with Francisella tularensis Identifies New Targets of Host Response Subversion." PLOS ONE. Vol. 3, no. 8. (August 2008.): e2924-.

Lapalombella, Gowda, Joshi, Mehter, Cheney, Lehman, Chen, Johnson, Caligiuri, Tridandapani, Muthusamy and Byrd. "The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in CLL." Brit. J. Hematol.. (January 2008.): -.

Parsa KVL, Butchar JP, Rajaram MVS, Gunn JS, Schlesinger LS, Tridandapani S. "Francisella gains a survival advantage within mononuclear phagocytes by suppressing host IFN? response.." Mol. Immunol.. Vol. 45, no. 12. (January 2008.): 3428-37.

Lapalombella, Yu, Triantafillou, Liu, Butchar, Lozanski, Ramanunni, Smith, Blum, Andritsos, Wang, Lehman, Chen, Johnson, Marcucci, Lee, Lee, Tridandapani, Muthusamy and Byrd. "Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of Rituximab on primary CLL cells." Blood. Vol. 112, no. 13. (January 2008.): 5180-5189.

Cremer, Amer, Tridandapani, Butchar. "Francisella tularensis regulates autophagy-related pathways." Autophagy. Vol. 1, no. 5. (January 2008.): 125-128.

Cremer,Thomas,J; Tridandapani,Susheela. "Effective host response to Francisella tularensis requires functional mast cells." FUTURE MICROBIOLOGY. Vol. 3, no. 5. (October 2008.): 503-506.

Crouser, Shao, Julian, Macre, Shadel, Tridandapani, Huang and Wewers. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors.." Crit. Care. Med.. (January 2008.): -.

Parsa, K.V.L., Butchar, J.P., Rajaram, M.V.S. and S. Tridandapani. "The tyrosine kinase Syk promotes the uptake of Francisella infection of human monocytes." Molecular Immunology. Vol. 45, no. 10. (January 2008.): 3012-3021.

Joshi, Ganesan, Cheney, Ostrowski, Muthusamy, Byrd and Tridandapani. "The PtdIns3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma." PLoS ONE. Vol. 1, no. 4. (January 2008.): e4208-.

Henning, Lisa, N; Azad, Abul, K; Parsa, Kishore V, L; Crowther, Joy, E; Tridandapani, Susheela; Schlesinger, Larry S. "Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages.." Journal of immunology (Baltimore, Md. : 1950). Vol. 180, no. 12. (January 2008.): -.

Joshi,Trupti; Ganesan,Latha,P; Cheney,Carolyn; Ostrowski,Michael,C; Muthusamy,Natarajan; Byrd,John,C; Tridandapani,Susheela. "The PtdIns 3-Kinase/Akt Pathway Regulates Macrophage-Mediated ADCC against B Cell Lymphoma." PLOS ONE. Vol. 4, no. 1. (January 2009.): e4208-.

Cremer,Thomas,J; Ravneberg,David,H; Clay,Corey,D; Piper-Hunter,Melissa,G; Marsh,Clay,B; Elton,Terry,S; Gunns,John,S; Amer,Amal; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "M1R-155 Induction by F. novicida but Not the Virulent F. tularensis Results in SHIP Down-Regulation and Enhanced Pro-Inflammatory Cytokine Response." PLOS ONE. Vol. 4, no. 12. (December 2009.): e8508-.

Cremer,Thomas,J; Amer,Amal; Tridandapani,Susheela; Butchar,Jonathan,P. "Francisella tularensis regulates autophagy-related host cell signaling pathways." AUTOPHAGY. Vol. 5, no. 1. (January 2009.): 125-128.

Akhter,Anwari; Gavrilin,Mikhail,A; Frantz,Laura; Washington,Songcerae; Ditty,Cameron; Limoli,Dominique; Day,Colby; Sarkar,Anasuya; Newland,Christie; Butchar,Jonathan; Marsh,Clay,B; Wewers,Mark,D; Tridandapani,Susheela; Kanneganti,Thirumala-Devi; Amer,Amal,O. "Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection." PLOS PATHOGENS. Vol. 5, no. 4. (April 2009.): e1000361-.

Cremer,Thomas,J; Ravneberg,David,H; Clay,Corey,D; Piper-Hunter,Melissa,G; Marsh,Clay,B; Elton,Terry,S; Gunn,John,S; Amer,Amal; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response.." PloS one. Vol. 4, no. 12. (January 2009.): e8508-.

Lapalombella,Rosa; Gowda,Aruna; Joshi,Trupti; Mehter,Najma; Cheney,Carolyn; Lehman,Amy; Chen,Ching-Shih; Johnson,Amy,J; Caligiuri,Michael,A; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 144, no. 6. (March 2009.): 848-855.

Crouser,Elliott,D; Shao,Guohong; Julian,Mark,W; Macre,Jennifer,E; Shadel,Gerald,S; Tridandapani,Susheela; Huang,Qin; Wewers,Mark,D. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." CRITICAL CARE MEDICINE. Vol. 37, no. 6. (June 2009.): 2000-2009.

Rajaram,Murugesan,VS; Butchar,Jonathan,P; Parsa,Kishore,VL; Cremer,Thomas,J; Amer,Amal; Schlesinger,Larry,S; Tridandapani,Susheela. "Akt and SHIP Modulate Francisella Escape from the Phagosome and Induction of the Fas-Mediated Death Pathway." PLOS ONE. Vol. 4, no. 11. (November 2009.): e7919-.

Butchar,Jonathan,P; Mehta,Payal; Justiniano,Steven,E; Guenterberg,Kristan,D; Kondadasula,Sri-Vidya; Mo,Xiaokui; Chemudupati,Mahesh; Kanneganti,Thirumala-Devi; Amer,Amal; Muthusamy,Natarajan; Jarjoura,David; Marsh,Clay,B; Carson,William,E; Byrd,John,C; Tridandapani,Susheela. "Reciprocal Regulation of Activating and Inhibitory Fc gamma Receptors by TLR7/8 Activation: Implications for Tumor Immunotherapy." CLINICAL CANCER RESEARCH. Vol. 16, no. 7. (April 2010.): 2065-2075.

Awan,Farrukh,T; Lapalombella,Rosa; Trotta,Rossana; Butchar,Jonathan,P; Yu,Bo; Benson,Don,M; Roda,Julie,M; Cheney,Carolyn; Mo,Xiaokui; Lehman,Amy; Jones,Jeffrey; Flynn,Joseph; Jarjoura,David; Desjarlais,John,R; Tridandapani,Susheela; Caligiuri,Michael,A; Muthusamy,Natarajan; Byrd,John,C. "CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody." BLOOD. Vol. 115, no. 6. (February 2010.): 1204-1213.

Yu J, Mitsui T, Wei M, Mao H, Butchar JP, Shah MV, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G, Benson DM Jr, Loughran TP Jr, Tridandapani S, Caligiuri MA.. "NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.." J Clin Invest.. Vol. 121(4), (January 2011.): 121(4):1456-70..

Cremer,Thomas,J; Shah,Prexy; Cormet-Boyaka,Estelle; Valvano,Miguel,A; Butchar,Jonathan,P; Tridandapani,Susheela. "Akt-Mediated Proinflammatory Response of Mononuclear Phagocytes Infected with Burkholderia cenocepacia Occurs by a Novel GSK3 beta-Dependent, I kappa B Kinase-Independent Mechanism." JOURNAL OF IMMUNOLOGY. Vol. 187, no. 2. (July 2011.): 635-643.

Mehta,Payal; Wavreille,Anne-Sophie; Justiniano,Steven,E; Marsh,Rachel,L; Yu,Jianhua; Burry,Richard,W; Jarjoura,David; Eubank,Timothy; Caligiuri,Michael,A; Butchar,Jonathan,P; Tridandapani,Susheela. "LyGDI, a Novel SHIP-Interacting Protein, Is a Negative Regulator of Fc gamma R-Mediated Phagocytosis." PLOS ONE. Vol. 6, no. 6. (June 2011.): e21175-.

Cremer,Thomas,John; Butchar,Jonathan,P; Tridandapani,Susheela. "Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt.." Frontiers in microbiology. Vol. 5, (January 2011.): 13-?.

Rennolds,Jessica; Malireddy,Smitha; Hassan,Fatemat; Tridandapani,Susheela; Parinandi,Narasimham; Boyaka,Prosper,N; Cormet-Boyaka,Estelle. "Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 417, no. 1. (January 2012.): 256-261.

Cormet-Boyaka,Estelle; Jolivette,Kalyn; Bonnegarde-Bernard,Astrid; Rennolds,Jessica; Hassan,Fatemat; Mehta,Payal; Tridandapani,Susheela; Webster-Marketon,Jeanette; Boyaka,Prosper,N. "An NF-kappa B-Independent and Erk1/2-Dependent Mechanism Controls CXCL8/IL-8 Responses of Airway Epithelial Cells to Cadmium." TOXICOLOGICAL SCIENCES. Vol. 125, no. 2. (February 2012.): 418-429.

Presentations

"Fc gamma Receptors: Multiplicity in Structure and Function." Dallas, TX, US|USA. (January 1999)

"Fc gamma Receptors: Multiplicity in Structure and Function." Ann Arbor, MI, US|USA. (January 1999)

"Modulation of Fc gamma receptor expression: A key to enhancing antibody therapy for cancer." Columbus, OH, US|USA. (January 2000)

"The Novel Inositol Phosphatase SHIP-2 Regulates FcR-mediated Signal Transduction in Macrophages." . (January 2003)

"Signal Transduction During Macrophage Innate Immune responses." . (January 2003)

"Regulation of FcRIIb Expression and Function by TH2 Cytokines." . (January 2003)

"Homeostatic Control of FcR-mediated Macrophage Function: Identification and Characterization of a Novel Regulatory Identification and Characterization of a Novel Regulatory Influence by SHIP-2." . (January 2003)

"Homeostatic Control of Fcganna receptor-mediated macrophage Function: Identification and Characterization of a Novel Regulatory Influence by SHIP-2." Presented at Regional Cancer center Consortium for Biological Treatment of Cancer, Columbus, OH, US|USA. (January 2003)

"Differential Regulation of Innate Immune Responses by Inositol Phosphatases: FcR versus TLR4." . (January 2003)

"Molecular Mechanisms Involved in the Regulation of Macrophage Response to Immune-Complexes." . (January 2004)

"Novel Role of Akt in FcR-Mediated Macrophage Function." . (January 2005)

"Molecular Mechanisms Involved in the Regulation of Macrophage Response to Immune-Complexes." . (January 2006)

"Homeostatic Control of macrophage inflammatory response to IgG immune complexes." Ithaca, NY, US|USA. (January 2006)

"Homeostatic Control of Macrophage Fc Receptor-Mediated Phagocytosis." Presented at Karl P. Klassen Lecture and Research Day, Columbus, OH, US|USA. (January 2006)

"Homeostatic control of Fc receptor function: Identification and Characterization of a novel regulatory influence by SHIP-2." Edmonton, AB, CA|CAN. (January 2006)

"Mechanisms of Macrophage Response to Antibody-Coated Target Cells." . (January 2007)

"Molecular Regulation of Macrophage Fcgamma receptor Function." . (January 2008)