Rami Khayat, MD

Current OSU Appointments

Associate Professor-Clinical, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

Clinical Interest

121

Chapters in Books

Ulysses J. Magalang, Rami Khayat, Naeem Ali. "Monitoring Respiration During Sleep." In Sleep: A comprehensive handbook. Edited by Teofilo L. Lee-Chiong. 1025-1030. Denver, CO: 2006 John Wiley & Sons, Inc, January 2005.

Rami Khayat and William Abraham. "Sleep related Breathing Disorders in the Acute Heart Failure Syndrome." In The Acute Heart Failure Syndrome. Edited by Alexander Mebazaa Joseph Perrillo. -. The Guildway, Old Portsmouth Road Guildford, GU3 1LP, UK: Springer-Verlag London Ltd Ashbourne House, January 2007.

Schaffernocker T, Khayat RN. "Sleep Apnea and Heart Failure." In Heart Failure: Principles and Clinical Management. -. New York, NY, US|USA: McGraw Hill, January 2011.

Journal Articles

LeMarbre, Gabrielle; Stauber, Shannon; Khayat, Rami, N; Puleo, Dominic, S; Skatrud, James, B; Morgan, Barbara J. "Baroreflex-induced sympathetic activation does not alter cerebrovascular CO2 responsiveness in humans.." The Journal of Physiology. Vol. 551, no. Pt 2. (January 2003.): 609-16.

Khayat, Rami, N; Xie, Ailiang; Patel, Ashvin, K; Kaminski, Ann; Skatrud, James B. "Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apnea." Chest. Vol. 123, no. 5. (January 2003.): 1551-60.

Khayat,R,N; Przybylowski,T; Meyer,K,C; Skatrud,J,B; Morgan,B,J. "Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans." Journal of Applied Physiology (Bethesda, Md. : 1985). Vol. 97, no. 2. (January 2004.): 635-40.

Xie,A,L; Skatrud,J,B; Khayat,R; Dempsey,J,A; Morgan,B; Russell,D. "Cerebrovascular response to carbon dioxide in patients with congestive heart failure.." American Journal of Respiratory and Critical Care Medicine. Vol. 172, no. 3. (January 2005.): 371-8.

Xie,Ailiang; Skatrud,James,B; Morgan,Barbara; Chenuel,Bruno; Khayat,Rami; Reichmuth,Kevin; Lin,Jenny; Dempsey,Jerome,A. "Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans." The Journal of Physiology. Vol. 577, no. Pt 1. (January 2006.): 319-29.

Valdivia-Arenas, Martin, A; Khayat, Rami. "An asian woman with eosinophilia and bilateral pulmonary infiltrates." Respiration: International Review of Thoracic Diseases. Vol. 74, no. 2. (January 2007.): 224-7.

Rami N. Khayat MD, FACCP, William T Abraham MD, Brian Patt BS, Monica Roy MPH, Keding Hua MS, and David Jarjoura PhD. "Cardiac Effects of Continuous and Bi-level Positive Airway Pressure for Patients with Heart Failure and Obstructive Sleep Apnea: A Pilot Study." Chest. Vol. 6, no. 134. (July 2008.): 1162-8.

Devulapally K, Pongonis R Jr, Khayat R.. "OSA: the new cardiovascular disease : Part II: overview of cardiovascular diseases associated with obstructive sleep apnea.." Heart failure Reviews. no. Epub-ahead of publication. (August 2008.): -.

Valdivia-Arnes and Rami Khayat. "Sleep-disordered breathing in patients with decompensated heart failure." Heart Failure Reviews. Vol. 3, no. 14. (August 2008.): 183-193.

Rami Khayat, MD, Brian Patt, BS, and Don Hayes, Jr., MD. "Obstructive Sleep Apnea and the Pathogenesis of Vascular Disease." Heart Failure Reviews. Vol. Sep; 14 (2), (August 2008.): 143-53.

Rami N Khayat, Andrew Pederzolli, William T. Abraham. "Central Sleep Apnea and Heart Failure." U.S. Cardiology (quarterly). (September 2009.): -.

Rami N Khayat, William T Abraham, Min Pu, Brian Patt, David Jarjoura. "In-hospital Treatment of Obstructive Sleep Apnea During Decompensation of Heart Failure." Chest. Vol. 4, no. 136. (October 2009.): 991-997.

Rami N Khayat, David Jarjoura, Brian Patt, Todd Yamokoski, William T Abraham. "In-hospital Testing for Sleep Disordered Breathing in Hospitalized Patients with Decompensated Heart Failure: Report of Prevalence and Patient Characteristics." Journal of Cardiac Failure. Vol. 9, no. 15. (January 2009.): 739-746.

Khayat,Rami; Patt,Brian; Hayes,Don. "Obstructive sleep apnea: the new cardiovascular disease. Part I: obstructive sleep apnea and the pathogenesis of vascular disease." HEART FAILURE REVIEWS. Vol. 14, no. 3. (September 2009.): 143-153.

Aneesa M Das, Rami Khayat. "Hypertension in Obstructive Sleep Apnea: Risk and Therapy." Expert Reviews. Vol. 7, no. 6. (June 2009.): 619-626.

Devulapally,Kiran; Pongonis,Raymond; Khayat,Rami. "OSA: the new cardiovascular disease." HEART FAILURE REVIEWS. Vol. 14, no. 3. (September 2009.): 155-164.

Patt,Brian,T; Jarjoura,David; Lambert,Lynn; Roy,Sashwati; Gordillo,Gayle; Schlanger,Richard; Sen,Chandan,K; Khayat,Rami,N. "Prevalence of Obstructive Sleep Apnea in Patients with Chronic Wounds." Journal of Clinical Sleep Medicine. Vol. 6, no. 6. (December 2010.): 541-545.

Patt,Brian,T; Jarjoura,David; Haddad,Diane,N; Sen,Chandan,K; Roy,Sashwati; Flavahan,Nicholas,A; Khayat,Rami,N. "Endothelial Dysfunction in the Microcirculation of Patients with Obstructive Sleep Apnea." American Journal of Respiratory and Critical Care Medicine. Vol. 12, no. 182. (July 2010.): 1540-1545.

Kahwash R, Kikta D, Khayat RN. "Recognition and Management of Sleep-Disordered Breathing in Chronic Heart Failure." Current Heart Failure Reports. Vol. 1, no. 8. (March 2011.): 72-79.

Ponikowski,Piotr; Javaheri,Shahrokh; Michalkiewicz,Dariusz; Bart,Bradley,A; Czarnecka,Danuta; Jastrzebski,Marek; Kusiak,Aleksander; Augostini,Ralph; Jagielski,Dariusz; Witkowski,Tomasz; Khayat,Rami,N; Oldenburg,Olaf; Gutleben,Klaus-Juergen; Bitter,Thomas; Karim,Rehan; Iber,Conn; Hasan,Ayesha; Hibler,Karl; Germany,Robin; Abraham,William,T. "Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea in Heart Failure." European Heart Journal. Vol. Apr;33(7), (August 2011.): 889-94.

Khayat,Rami; Abraham,William; Patt,Brian; Brinkman,Vincent; Wannemacher,Jacob; Porter,Kyle; Jarjoura,David. "Central Sleep Apnea is a Predictor of Cardiac Readmission in Hospitalized Patients With Systolic Heart Failure." JOURNAL OF CARDIAC FAILURE. Vol. 18, no. 7. (July 2012.): 534-540.

Troy Schaffernocker and Rami Khayat. "Management of Central Sleep Apnea." U.S Cardiology. Vol. 2012;9(1), (January 2012.): online Journal-.

Campbell, Leah; Best, Janet; Khayat, Rami; Splaingard, Mark. "Issues Applying Math Model to Estimate CPAP Response in CSR." American Journal of Respiratory and Critical Care Medicine. -.

Roy Small; Lisa Rathman; Steven Krueger; Becky Gocke; Linda Clark; Laura Yamokoski; William T. Abraham. "Sleep Disordered Breathing in Heart Failure: Identifying and Treating an Important but Often Unrecognized Comorbidity in Heart Failure Patients." Journal of Cardiac Failure. -.

Javaheri S, Goetting M, Khayat RN, Wylie P, Goodwin J, Parthasarathy S. "The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea." Sleep. -.

Reference Works

January 1999	Rami N. Khayat, Daling Zhu, and Elizabeth RJacobs."Chronic hypoxia induces epoxyeicosatrienoic acids (EETS) in neonatal rabbit lungs" .
January 2002	Rami N. Khayat, MD, Ailiang Xie PhD, and James Skatrud, MD."The ventilatory and cardiovascular effects of dead space in patients with CHF-CSA" .
January 2003	Rami N. Khayat, Barbara Morgan, James Skatrud, and Jerry Dempsey."The role of pulmonary stretch reflex in neurocirculatory response to apnea" .
January 2003	Xie, R.N. Khayat, D.S. Puleo, B.J. Morgan, J.B. Skatrud."Cerebrovascular Response to CO2 in Patients with Congestive Heart Failure" .
January 2004	A. Xie, R. Khayat, J.A. Dempsey, B. Chenuel, J.H. Lin, J.B. Skatrud."Effect of Cerebrovascular Reactivity to CO2 on the Hypercapnic Ventilatory Response" .
January 2007	RN Khayat, D Jarjoura, B Patt, WT Abraham."Comparison between CPAP and BIPAP for the Treatment of OSA in Patients with Chronic Systolic Heart Failure" .
September 2007	R . Khayat , B . Patt , T . Yamokoski , W . Abraham."Obstructive Sleep Apena May Play a Role in the Acute Decompensation of Heart Failure" . : S172
January 2008	B. Patt, R. N. Khayat, , S. Roy, G. Gordillo, R. Schlanger, L. Lambert, & C. K. Sen."Risk Factors and Role of Obstructive Sleep Apnea in Patients with Chronic Non-Healing Wounds" .
June 2008	Rami Khayat, Brian Patt, Stephen Schutzman, David Jarjoura, and William Abraham."Role of Obstructive Sleep Apnea in the Acute Decompensation of Heart Failure" .
January 2008	Rami N Khayat, Brian Patt, Roger Holt, Xiaoxue Fan, Min Pu."Beneficial Effects of Continuous Positive Airway Pressure on LV Diastolic Function in Patients with Congestive Heart Failure and Obstructive Sleep Apnea" .
April 2008	R. N. Khayat, S. J. Schutzman, B. T, Patt, , S. Roy, G. Gordillo, R. Schlanger, L. Lambert, K. Rose, U. Gnyawali, A. Coston and C. K. Sen."Prevalence of Obstructive Sleep Apnea In Patients of an Academic Wound Center" . : A10–A58
June 2008	Brian Patt B.S. Jian Sun PhD , Jay Zweier MD , Arturo Cardounel PhD, Stephen Schutzman B.S., Rami Khayat MD."Endothelial Dysfunction in Obstructive Sleep Apnea and The Role of Endogenous Inhibitors Of Nitric Oxide" .
June 2009	Haddad, D., Patt, B.,Yearsley, K., Khayat, R.."Oxidative Stress and Endothelial Dysfunction in Patients with Obstructive Sleep Apnea" .
January 2009	Brian Patt, Lynn Lambert, Sashwati Roy, Gayle Gordillo, Richard Schlanger, & Chandan. K. Sen, Rami Khayat."Validation of Obstructive Sleep Apnea Screening of Patients in an Academic Wound Center" .
September 2009	Javaheri S, Goetting M, Khayat RN, Goodwin J, Wyle P."The ability of auto servo ventilation to eliminate complex central sleep apnea" Vienna.
May 2010	B. Patt, M. Powers, J. Wannemacher, R. Khayat."Central Sleep Apnea Predicts Post-Discharge Readmission in Patients with Decompensated Heart Failure" New Orleans.
May 2010	J. Wannemacher, B. Patt, R. Khayat."The Inflammatory Response in OSA and its Relation to Endothelial Dysfunction" New Orleans.
June 2010	Khayat RN, et al.."A Novel Approach Using Phrenic Nerve Stimulation to Treat Central Sleep Apnea: First-In-Man Experience" .
January 2010	Ponikowski P, Zhang SJ, Witkowski T, Hasan A, Khayat RN, Bart B, Jagielski D, Zhang X."Central Sleep Apnea Events are Terminated by Phrenic Nerve Stimulations" . : E289
November 2012	Varadharaj Jacob Wannemacher, Brian Patt, Hemalatha Rao, Levy Reyes, Jay L Zweier, Rami Khayat."S-glutathionylation of eNOS occurs in Clinical Obstructive Sleep Apnea (OSA)" Los Angeles.
November 2012	Saradhadevi Varadharaj Jacob Wannemacher, Brian Patt, Hemalatha Rao, Levy Reyes, Jay L Zweier, Rami Khayat."Saradhadevi Varadharaj Jacob Wannemacher, Brian Patt, Hemalatha Rao, Levy Reyes, Jay L Zweier, Rami Khayat" Los Angeles.

Presentations

"Treatment of CHF-CSA." Presented at Wisconsin Thoracic Society Annual Meeting, . (January 2001)

"Thromboembolic Disease in the ICU." Presented at Tri-State Thoracic Society International Conference, . (January 2001)

"Pathophysiology and Treatment of Cheyne-Stokes Respiration." Presented at American Thoracic Society International Conference, San Diego, CA. (May 2001)

"Weaning from Mechanical Ventilation." Presented at Annual Pulmonary and Critical care symposium, Columbus, OH. (November 2004)

"Prevention of Nosocomial Complications in the ICU." Presented at Continued Medical Education Symposium, Columbus, OH. (March 2005)

"Sleep Disordered Breathing and Heart Failure." Presented at The Annual OSU “Heart at the Shoe” Symposium, Columbus, OH. (November 2007)

"Obstructive Sleep Apnea and Chronic Non-Healing Wounds." Presented at Annual Meeting of the National Wound Healing Society, San Diego, CA. (April 2008)

"Sleep and Sleepiness for the Artist." Presented at Workshop, Columbus, OH. (January 2008)

"Sleep Disordered Breathing in the Hospitalized Patient with Cardiovascular Disease." Presented at The Heart of it All-Annual Ross Hospital Nursing Conference, . (January 2008)

"Sleep Disordered Breathing- Case based approach." Presented at MedNet 21 televised lecture series Critical Care Curriculum, Columbus, OH. (May 2008)

"Sleep Disordered Breathing in Heart Failure: Emerging concepts in identification and treatment." Presented at Medical Grand Rounds, University of Texas-Houston, Houston, TX. (July 2009)

"Obstructive Sleep Apnea: a cardiovascular disorder." Presented at Mount Sinai Medical Center Grand Rounds, Dayton, OH. (March 2009)

"The Cardiovascular Consequences of Obstructive Sleep Apnea." Presented at American College of Cardiology-Ohio Chapter Meeting, OH. (October 2009)

"OSA and cardiovascular metabolic risk." Presented at Lipid Update: Cardiometabolic Risk, OSU CME Conference, Columbus, OH. (February 2009)

"Obstructive Sleep Apnea: Presentation and Management for the Respiratory Therapist." Presented at Current Concepts in Respiratory Care Conference, . (April 2009)

"Obstructive Sleep Apnea and Wound Healing - An Important Co-morbidity." Presented at Wound Care and HBO Update, . (April 2009)

"Obstructive Sleep Apnea - Cardiovascular complications and Surveillance in High Risk Populations." Presented at Columbia Medical Grand Rounds, Boone Medical Center, . (April 2009)

"Healthy Hearts." Presented at Indiana Sleep Society, IN. (August 2009)

"Anemia in ICU." Presented at SELECT Annual Medical Director and CEO Meeting, Washington, DC. (April 2010)

"The Cardiovascular Complications of Obstructive Sleep Apnea." Presented at The 32nd Annual Ohio Society for Respiratory Care State Meeting, . (August 2010)

"Novel Approach to the Treatment of Central Sleep Apnea." Presented at The American Academy of Sleep Medicine Annual Meeting, . (June 2010)

"Sleep Disordered Breathing for the Respiratory Therapist." Presented at The 2010 Blue Ridge Symposium, Sleep Conference, Front Royal, VA. (September 2010)

"Obstructive Sleep Apnea: What does the primary care physician need to know?." Presented at CME Symposium, 2010 Update on Sleep Disorders, Madison, WI, US|USA. (September 2010)

"OSA in the Operating Room: Approach to patients with OSA in the pre-operative area." Presented at The Blue Ridge Symposium, Front Royal, VA. (September 2011)

"Sleep Disordered Breathing and Heart Failure." Presented at National Sleep Meeting, Keynote Symposium, Columbus, OH. (October 2011)

"Sleep Heart ACC summit." Presented at Sleep and Heart Summit; The American College of Cardiology, Washington, DC. (December 2011)

"Sleep Disorderd Breathing and Heart Failure." Presented at Grand Rounds, Toledo, OH. (January 2012)

"Sleep Disordered Breathing: A Novel Target in the Management of Decompensated Heart Failure." Presented at Positive Airway pressure and Heart Failure 7th Annual Conference, Tokyo, JP|JPN. (February 2013)

"Sleep Disordered Breathing- Update on Diagnosis and Treatment." Presented at Special seminar, Keio Medical School, Tokyo, JP|JPN. (February 2013)