Ohio State Navbar


Patrick Nana-Sinkam, MD

Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: nana-sinkam.1@osu.edu


Current OSU Appointments

Associate Professor, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep



Dr. Patrick Nana-Sinkam is an Associate Professor of Internal Medicine and Co-Director Research Programs in the Division of Pulmonary Allergy, Critical Care and Sleep Medicine. He conducted his residency training in Internal Medicine at the University of Michigan where he also served as chief resident. He completed his fellowship in Pulmonary and Critical Care at the University of Colorado and was recruited to Ohio State in 2006. Dr. Nana-Sinkam has an active research program in biomarker discovery in smoking related lung diseases including examining the role of microRNAs in lung cancer development and progression. He has been the recipient of several awards from the International Association for the Study of Lung Cancer and Chest Foundation. He has served on several study sections including the Department of Defense and American Lung Association. In addition to reviewing for several journals, he currently serves on the editorial board of the American Journal of Respiratory and Critical Care Medicine.

Chapters in Books

Gerard J. Nuovo, Patrick Nana-Sinkam, Melissa Crawford, Thomas D. Schmittgen. "In Situ Detection of MicroRNAs in Paraffin-Embedded, Formalin-Fixed Tissues: Different Methodologies and Co-localization with Possible Targets." In RNA Interference Techniques. Edited by Scott Q. Harper. -. Columbus, OH: Springer Protocols, January 2011.


Editorial Activities

2006 - present AJP-Lung Cellular and Molecular Physiology
2006 - 2007 Lung Cancer Frontiers
2007 - present Faculty of 1000 Medicine (Lung Cancer)
2009 - present Neoplasia
2009 - present American Journal of Respiratory Cell and Molecular Biology
2009 - present International Journal of Cancer
2010 - present BMC Genomics
2011 - present American Journal of Respiratory and Critical Care Medicine (Impact factor 10.6)

Journal Articles

Wu, X., Hunter, M.G., Crawford, M., Nuovo, G.J., Marsh, C.B., Otterson, G.A., Nana-Sinkam, S.P.. "4.5." Journal of Thoracic Oncology. (January 2009.): -.

Nana-Sinkam, S.P., Hunter, M.G., Nuovo, G.J., Schmittgen, T.D., Gelinas, R., Galas, D., Marsh, C.B.. American Journal of Respiratory and Critical Care Medicine. Vol. 179, no. Journal Cover. (January 2009.): 4-10.

Nana-Sinkam,S,Patrick; Croce,Carlo,M. "MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application." CANCER GENETICS AND CYTOGENETICS. Vol. 203, no. 2. (December 2010.): 127-133.

Yan,Fengting; Wu,Xin; Crawford,Melissa; Duan,Wenrui; Wilding,Emily,E; Gao,Li; Nana-Sinkam,S,Patrick; Villalona-Calero,Miguel,A; Baiocchi,Robert,A; Otterson,Gregory,A. "The search for an optimal DNA, RNA, and protein detection by in situ hybridization, immunohistochemistry, and solution-based methods." METHODS. Vol. 52, no. 4. (December 2010.): 281-286.

Zimmerman, E.I., Dollins, C.M., Crawford, M., Grant, S., Nana-Sinkam, S.P., Richards, K.L., Hammond, S.M., Graves, L.M.. "lyn Kinase-dependent Regulation of miR-181b and MCL-1 Expression: Implications for Drug Resistance in Myelogenous Leukemia." Molecular Pharmacology. (January 2010.): -.

Nana-Sinkam, S.P.,Fabbri, M., Croce, C.M. "MicroRNA in cancer: Personalizing diagnosis and therapy." Annals of New York Academy of Sciences. (January 2010.): -.

Nana-Sinkam, S.P. and Croce, C.M.. "MircoRNA deregulation in cancer: Opportunities for the development of miroRNA-based drugs." Drugs. (January 2010.): -.

Piper, M.G., Sweet, K., Marsh, C.B., Nana-Sinkam, S.P.. Personalized Medicine. (January 2011.): -.

Wu, Y.; Crawford, M.; Yu, B.; Mao, Y.; Nana-Sinkam, S.P.; Lee, J.. "MicroRNA delivery by cationic lipoplexes for lung cancer therapy." Molecular Pharmaceutics. (January 2011.): -.

Nana-Sinkam, S.P. and Croce, C.M.. "Noncoding RNAs in cancer initiation and progression and as novel biomarkers." Molecular Oncology. (January 2011.): -.

Nana-Sinkam, S.P. and Croce, C.M. "microRNA as therapeutic targets in cancer." Translational Research. Vol. 157, no. 4. (April 2011.): 216-225.

24. Ezzie, M.E., Crawford, M., Cho, J., Orellana, R., Zhang, S., Gelina, R., Batte, K., Yu, L., Nuovo, G., Galas, D., Diaz, P., Wang, K., Nana-Sinkam, S.P.. "Gene expression networks in COPD: microRNA and mRNA regulation." Thorax. (September 2011.): -.


Reference Works

January 2010 B. Pronold, M. Asif, S.P. Nana-Sinkam."The dreaded consequence of TNF-a inhibitors" .
January 2011 Yan Huang, Melissa Crawford, Natalia Higuita-Castro, Patrick Nana-Sinkam, Samir Ghadiali."Regulation of Mechanotransduction and Inflammation by miR-146a in Primary Lung Epithelial Cells" .
January 2011 J. Napolitano, M. Liu, S. Bao, E. Cormet-Boyaka,E., M. Crawford, S.P. Nana-Sinkam, D. Knoell."Cadmium-Induced Lung Epithelial Cell Toxicity Is Mediated Through NF-κB Dependent Zip8 Transport" .
January 2011 Ahmad Malas, Jarrod Bruce, Patrick Nana-Sinkam."Diuretic-refractory flash pulmonary edema: a case of subacute Gemcitabine-induced pulmonary toxicity" .
January 2011 S.N. Ghadiali, Y. Huang, M. Crawford, P. Nana-Sinkam."Role Of Micro-RNAs In Regulating Mechanically Induced Inflammation In Human Small Airway Epithelial Cells" .
January 2011 Gregory A. Otterson MD, Erin M. Bertino MD, Nagla A Karim MD, Kavitha Donthireddy MD, Ahmed M. Ghany MD, Robert Rupert MD, Sarah Cantrell, Meliha Rahmani, Melinda Lynn, S. Patrick Nana-Sinkam MD, Gary S. Phillips, Miguel A. Villalona-Calero MD."Phase II Trial of nab-paclitaxel plus carboplatin in patients with advanced NSCLC at risk of bleeding from VEGF directed therapies" .


"Lung Cancer Screening in 2011: Is the Debate Over?." Presented at Grand Rounds, Mansfield, OH. (June 2011)

"Targeting Microrna in Smoking Related Lung Disease." Presented at Cleveland Clinic Genomics Medicine Research Conference, Cleveland, OH. (January 2011)

"Regulating gene Expression:MiRNA, Growth factors." Presented at American Thoracic Society, Denver, CO. (May 2011)

"Omics Approaches to lung disease." Presented at American Thoracic Society, Denver, CO. (May 2011)