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Patrick Nana-Sinkam, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: nana-sinkam.1@osu.edu

 

Current OSU Appointments

Associate Professor, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

 

Biographical

Dr. Patrick Nana-Sinkam is an Associate Professor of Internal Medicine and Co-Director Research Programs in the Division of Pulmonary Allergy, Critical Care and Sleep Medicine. He conducted his residency training in Internal Medicine at the University of Michigan where he also served as chief resident. He completed his fellowship in Pulmonary and Critical Care at the University of Colorado and was recruited to Ohio State in 2006. Dr. Nana-Sinkam has an active research program in biomarker discovery in smoking related lung diseases including examining the role of microRNAs in lung cancer development and progression. He has been the recipient of several awards from the International Association for the Study of Lung Cancer and Chest Foundation. He has served on several study sections including the Department of Defense and American Lung Association. In addition to reviewing for several journals, he currently serves on the editorial board of the American Journal of Respiratory and Critical Care Medicine.

Clinical Interest

Smoking Related Lung Disease

Critical Care

Thoracic malignancies

Academic Advising

2014 - present Jennifer Fleming, The Ohio State University.
2014 - present Vincent Esguerra, The Ohio State University.
2004 - 2006 Sylk Sotto-Santiago The Ohio State University.
2004 - 2006 Qamrul Choudhery, The Ohio State University.
2007 Kara Batte The Ohio State University.
2007 - 2008 Emily Brawner, The Ohio State University. Role of MicroRNAs in Lung Tumorigenesis
2008 Ijeoma Ibezue The Ohio State University.
2007 - 2009 Hussam Salhi The Ohio State University.
2007 - 2009 Aaron Bruns The Ohio State University.
2008 - 2009 Lindsay Brace The Ohio State University. Graduated 2008.
2007 - 2010 Brent Riscilli, The Ohio State University. Graduated 2010.
2009 - 2010 Sainath Kotha, The Ohio State University.
2009 - 2010 Sara McMacken The Ohio State University.
2007 - 2011 Michael Ezzie, The Ohio State University.
2009 - 2011 Yan Huang, The Ohio State University.
2012 Vasudha Shukla, The Ohio State University.
2006 - 2013 Melissa Crawford The Ohio State University.
2010 - 2013 Yung Wu, The Ohio State University.
2011 - 2013 Basant Abdulrahman The Ohio State University.
2012 - 2013 Hye-Won Kang The Ohio State University.
2013 Young-Jun Jeon The Ohio State University.
2011 - 2014 Mia Tazi The Ohio State University.
2012 - 2014 Kevin Nelson The Ohio State University.
2013 - 2014 Hiram Rivas-Perez The Ohio State University. Graduated 2014.
2014 Kin Chung The Ohio State University.
 

Certifications

1996 - present Board Certification: National Board of Medical Examiners
2002 - present Board Certification: American Board of Internal Medicine
2003 - present Board Certification: American Board of Internal Medicine
2006 - present Medical License: State Medical Board of Ohio
2015 - present ACLS: Advanced Cardiac Life Support
1999 - 2009 Board Certification: American Board of Internal Medicine
 

Chapters in Books

Nana-Sinkam P, Geraci M. "Fat Embolism Syndrome." In Critical Care Secrets. Edited by 3ed. 408-411. Parsons, P.E. and Weiner-Kronish, J.P., January 2002.

Keith RL, Miller YE, Bunn PA, Nana-Sinkam P, Nemenoff RA, Geraci MW. "Prostacyclin and Lung Cancer Chemoprevention." In Cancer Chemoprevention Volume 1: Promising Cancer Chemopreventative Agents. -. January 2003.

Dr. Patrick Nana-Sinkam. "Pulmonary Thromboembolism." In Current Diagnosis and Treatment in Pulmonary Medicine. -. Hanley and Welsh, January 2004.

Gerard J. Nuovo, Patrick Nana-Sinkam, Melissa Crawford, Thomas D. Schmittgen. "In Situ Detection of MicroRNAs in Paraffin-Embedded, Formalin-Fixed Tissues: Different Methodologies and Co-localization with Possible Targets." In RNA Interference Techniques. Edited by Scott Q. Harper. -. Columbus, OH: Springer Protocols, January 2011.

Huang, Y, Ghadiali, SN, Nana-Sinkam, SP. "microRNAs and Inflammation, 2013." In MicroRNAs in Toxicology and Medicine. Edited by Saura Sahu. -. /: Wiley, January 2013.

Nana-Sinkam, SP, Croce, CM. "micro RNAs and Cancer." In PRactical Application in Adult Patient Care. -. /: /, January 2013.

Horne, L, Araujo, L, Nana-Sinkam, SP, Ottorson, G, Williams, T, Carbone, DP. "Molecular Biology of Lung Cancer." In Devita, Hellamn, and Rosenberg's Cancer: Principles and Practice of Oncology. -. /: /, January 2014.

Dakhallah, D, Piper, M, and Nana-Sinkam, SP. "Translational Implications for ncRNA in Cancer." In Non-coding RNAs and cancer. -. /: Springer, January 2014.

Piper, M, Dakhlallah, D, Wang, Y, Moldovan, L, Trgovich, J, Anderson, T, Ezzie, M, Nana-Sinkam, P, Cook, C, Mohler, P, Marsh, C. "Circulating miRNAs as Biomarkers." In /. -. /: /, January 2014.

 

Clinical Services

08/01/2006 Inpatient Medical Service (OSU Main, OSU East, Ross, James)
08/01/2006 Outpatient Clinical Service (James Tower/ James Thoracic Center)

Degrees

1990 B.A., Williams College

1996 M.D., Wake Forest University

 

Editorial Activities

2005 - present Blood Coagulation and Fibrinolysis
2006 - present Journal of Thoracic Oncology
2006 - present American Journal of Respiratory and Critical Care Medicine
2006 - present Chest
2006 - present AJP-Lung Cellular and Molecular Physiology
2006 - 2007 Lung Cancer Frontiers
2007 - present Faculty of 1000 Medicine (Lung Cancer)
2007 - present Experimental Lung Research
2007 - present Clinical Medicine:Circulatory, Respiratory and Pulmonary Medicine
2007 - present Prostaglandins and Other Lipid mediators
2007 Lung Cancer Frontiers
2008 - present Clinical Chemistry
2008 - present ATS RCMB Symposia and Post Graduate Course
2008 - present Lung Cancer
2008 - present International Journal of COPD
2009 - present Neoplasia
2009 - present RNA Biology
2009 - present Environmental Health Perspectives
2009 - present American Journal of Respiratory Cell and Molecular Biology
2009 - present Translational Research
2009 - present Cancer Genetics and Cytogenetics
2009 - present CANCER
2009 - present International Journal of Cancer
2009 - present Acta Biochimica et Biophysica Sinica (ABBS)
2009 - present Acta Pharmacologica Sinica
2009 - present FEBS Journal
2009 - present European Respiratory Journal
2009 - present Methods
2010 - present Journal of Translational Medicine
2010 - present Cell Research
2010 - present BMC Genomics
2011 - present American Journal of Respiratory and Critical Care Medicine (Impact factor 11.9)
2013 - present Journal of Thoracic Oncology (Impact factor 5.8)
2014 - present Frontiers in Thoracic Oncology
 

Honors

1991 - 1996 Minority Academic Scholarship.
1997 Laure Edmunds Award for Outstanding House Officer.
1999 House Officer of the Month.
2003 International Association for the Study of Lung Cancer Young Investigator Award. International Association for the Study of Lung Cancer.
2003 American Thoracic Society Minority Travel Award. American Thoracic Society.
2005 - 2006 UCHSC SPORE in Lung Cancer Career Development Award.
2006 American Society for Clinical Investigation Travel Award. American Society for Clinical Investigation.
2007 - present CHEST/LUNGevity Award for Clinical Research in Lung Cancer (1 award annually). CHEST.
2007 - present Fellow. American College of Chest Physicians.
2007 - 2008 Best Doctors in America. US News and World Report.
2008 Academic and Private Practice Leadership Program. American College of Chest Physicians.
2009 - 2014 Best Doctors in America. US News and World Report.
2010 - 2011 Who's Who in Black Columbus. Real Times Media, Who's Who Publishing.
2012 - present Granted Tenure. The Ohio State University.
 

Journal Articles

Belgrave, F; Kelley, K; Molock, S; Nana-Sinkam, SP. "Psychological factors influencing physical health in African-American college students." The Journal of Black Psychology. Vol. 18, (January 1991.): 1-17.

Jarow, J; Nana-Sinkam, SP; Sabbagh, M; Eskew, A. "Outcome analysis of goal directed therapy for impotence.." The Journal of urology. Vol. 155, no. 5. (January 1996.): 1609-1612.

Mancuso, P; Nana-Sinkam, SP; Peters-Golden, M. "Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumonia.." Infection and immunity. Vol. 69, no. 4. (January 2001.): 2011-2016.

Nana-Sinkam, SP, Welsh, C. "Pulmonary Embolism: Diagnostic Strategies and Management." Primary Care Case Reviews. Vol. 5, (March 2002.): 28-39.

Nana-Sinkam, SP; Hoshikawa, Y; Moore, MD; Keith, RL; Morris, KG; Kondo, T; Tuder, RM; Voelkel, NF; Geraci, MW. "Chronic Hypoxia induces different genes in the lungs of rats when compared with mice.." Physiological genomics. Vol. 12, no. 3. (January 2003.): 209-219.

Keith, RL; Miller, YE; Hudish, TM; Girod, CE; Sotto-Santiago, S; Franklin, WA; Nemenoff, RA; March, TH; Nana-Sinkam, SP; Geraci, Mark W. "Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice.." Cancer research. Vol. 64, no. 16. (August 2004.): 5897-5904.

Nana-Sinkam, SP; Golpon, H; Keith, RL; Oyer, RJ; Sotto-Santiago, S; Moore, MD; Franklin, W; Nemenoff, RA; Geraci, MW. "Prostacyclin in human non-small cell lung cancers.." Chest. Vol. 125, no. 5 Suppl. (January 2004.): 141S-.

Bull, TM; Coldren, CD; Moore, M; Sotto-Santiago, SM; Pham, DV; Nana-Sinkam, SP; Voelkel, NF; Geraci, MW. "Gene microarray analysis of peripheral blood cells in pulmonary arterial hypertension." American journal of respiratory and critical care medicine. Vol. 170, no. 8. (October 2004.): 911-919.

Nana-Sinkam, SP; Oyer, RJ; Stearman, RS; Sotto-Santiago, S; Moore, MD; Bull, TM; Grady, MC; Choudhery, Q; Nemenoff, RA; Lane, K; Loyd, JE; Geraci, MW. "Prostacyclin synthase promoter regulation and familial pulmonary arterial hypertension.." Chest. Vol. 128, no. 6 Suppl. (January 2005.): 612S-.

Keith, RL; Geraci, MW; Nana-Sinkam, SP; Breyer, RM; Hudish, TM; Meyer, AM; Malkinson, AM; Dwyer-Nield, LD. "Prostaglandin E-2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis." Anticancer research. Vol. 26, no. 4B. (July 2006.): 2857-2861.

Taraseviciene-Stewart, L; Douglas, IS; Nana-Sinkam, PS; Lee, JD; Tuder, RM; Nicolls, MR; Voelkel, NF. "Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?." Proceedings of the American Thoracic Society. Vol. 3, no. 8. (January 2006.): 687-690.

Taraseviciene-Stewart, L, Dogulas, IS, Nana-Sinkam, SP, Lee, JD, Tuder, RM, Nicolls, MR, Voelkel, NF. "Is Alveolar Destruction and Emphysema in Chronic Obsstructive Pulmonary Disease an Immune Disease?." Proc Am Thorac Soc. Vol. 3, (November 2006.): 687-90.

Nana-Sinkam, SP; Geraci, MW. "Review of MicroRNA in lung cancer." Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer. Vol. 1, (January 2006.): 929-931.

Nana-Sinkam, SP; Lee, JD; Stearman, R; Sakao, S; Sotto-Santiago, S; Voelkel, NF; Geraci, MW. "Prostacyclin synthase in smoking-related lung disease.." Proceedings of the American Thoracic Society. Vol. 3, no. 6. (August 2006.): 517-.

Nana-Sinkam, SP; Lee, LD; Sotto-Santiago, S; Stearman, RS; Keith, RL; Choudhury, Q; Cool, C; Parr, J; Moore, MD; Bull, TM; Voelkel, NF; Geraci, MW. "Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 175, no. 7. (April 2007.): 676-685.

Nana-Sinkam, SP. "New Genomic and Proteomic Studies in Lung Cancer Biomarker Detection." Lung Cancer Fronteirs. Vol. /, (January 2007.): 1-5.

Nana-Sinkam, SP; Lee, JD; Sotto-Santiago, S; Stearman, RS; Keith, RL; Choudhury, Q; Cool, C; Parr, J; Moore, MD; Bull, TM; Voelkel, NF; Geraci, MW. "Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke. (Journal Cover)." American journal of respiratory and critical care medicine. Vol. 175, no. 7. (January 2007.): 676-685.

Stearman, RS; Grady, MC; Nana-Sinkam, SP; Varella-Garcia, M; Geraci, MW. "Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.." Molecular cancer research : MCR. Vol. 5, no. 3. (January 2007.): 295-308.

Stearman, RS; Grady, M; Nana-Sinkam, SP; Garcia, M; Geraci, MW. "Multifacted regulation of human prostacyclin synthase promoter in lung cancer cell lines." Mol Cancer Res. Vol. 5, no. 3. (March 2007.): 295-308.

Hunter, M; Wang, Y; Eubank, T; Baran, C; Nana-Sinkam, SP; Marsh, CB. "Review of Survival of monocytes and macrophages and their role in health disease." Frontiers in Bioscience. Vol. ., (January 2008.): .-.

Crawford, M; Brawner, E; Batte, K; Yu, L; Hunter, M; Otterson, G; Nuovo, GJ; Marsh, CB; Nana-Sinkam, SP. "MicroRNA-126 inhibits invasion in non-small cell lung cancer cell lines." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 373, no. 4. (September 2008.): 607-612.

Bull, TM; Meadows, CA; Coldren, CD; Moore, M; Sotto-Santiago, SM; Nana-Sinkam, SP; Campbell, TB; Geraci, MW. "Human Herpesvirus-8 Infection of Primary Pulmonary Microvascular Endothelial Cells." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 39, no. 6. (December 2008.): 706-716.

Young, RL; Mitchell, JD; Cool, C; Nana-Sinkam, SP. "Wheezing and dyspnea in a 25-year-old mountaineer." Chest. Vol. 3, no. 133. (January 2008.): 820-825.

Brawner, E; Nana-Sinkam, SP; Jett, J. "Review of Lung Cancer Screening in 2008: Review and Update." Respiratory Medicine. Vol. 1, (January 2008.): 2-9.

Bull, TM; Meadows, CA; Coldren, CD; Moore, M; Sotto-Santiago, SM; Nana-Sinkam, SP; Campbell, TB; Geraci, MW. "Human Herpesvirus-8 infection of primary pulmonary microvascular endothelial cells,." Am J Respir Cell Mol Biol. Vol. 6, no. 39. (June 2008.): 706-716.

Hunter, MG; Ismail, N; Zhang, X; Aguda, BD; Lee, EJ; Yu, L; Xiao, T; Schafer, J; Lee, M; Schmittgen, T; Nana-Sinkam, SP; Jarjoura, D; Marsh, CB. "Identification and characterization of miRNA expression in human peripheral blood microvesicles." PLOS ONE. Vol. 3, no. 11. (November 2008.): e3694-.

Nana-Sinkam, SP; Hunter, MG; Nuovo, GJ; Schmittgen, TD; Gelinas, R; Galas, D; Marsh,CB. "Integrating the MicroRNome into the Study of Lung Disease." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 179, no. 1. (January 2009.): 4-10.

Ezzie, ME; Yu, L; Batte, K; Crawford, M; Diaz, PT; Nana-Sinkam, SP. "A Distinct microRNA Profile Distinguishes GOLD Stages in COPD." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 179, (January 2009.): /-.

Exline, MC; Hollyfield, JL; Gavrilin ,MA; Nana-Sinkam, SP; Wewers, MD. "Cigarette Smoke Extract Suppresses Innate Immune Response in Peripheral Blood Monocytes.." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 179, (January 2009.): /-.

Crawford, M; Batte, K; Yu, L; Wu, X; Otterson, GA; Nana-Sinkam, SP. "MicroRNA 133B Sensitizes Non Small Cell Lung Cancer to Chemotherapeutic Agents by Targeting BCLw.." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 179, (January 2009.): /-.

Wu, X; Piper-Hunter, MG; Crawford, M; Nuovo, GJ; Marsh, CB; Otterson, GA; Nana-Sinkam, SP. "MicroRNAs in the Pathogenesis of Lung Cancer." JOURNAL OF THORACIC ONCOLOGY. Vol. 4 (Journal cover), no. 8. (August 2009.): 1028-1034.

Nana-Sinkam, SP; Karsies, T; Riscili, B; Ezzie, M; Piper, M. "Lung microRNA: from development to disease.." Expert review of respiratory medicine. Vol. 3, no. 4. (August 2009.): 373-385.

Hunter, M; Wang, Y; Eubank, T; Baran, C; Nana-Sinkam, SP, Marsh ,CB. "Survival of monocytes and macrophages and their role in health and disease." Frontiers in Bioscience. Vol. 14, (January 2009.): 4079-4102.

Nouvo, GJ., Elton,TS., Nana-Sinkam, SP., Volinia,S., Croce,CM., , Schmittgen, TS. "A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with putative miR targets." Nature protocols. Vol. 4, no. 1. (January 2009.): 107-115.

Nana-Sinkam, SP; Hunter, MG; Nuovo, GJ; Schmittgen, TD; Gelinas, R; Galas, D; Marsh, CB. "Review of Integrating the microRNome into the study of lung disease." American Journal of Respiratory and Critical Care Medicine. Vol. 179, no. Journal Cover. (January 2009.): 4-10.

Nana-Sinkam, S.P., Karsies, T., Riscilli, B., Ezzie, E.M., Piper-Hunter, M.. "Review of Lung microRNAs: From Development to Disease." Expert Review of Respiratory Medicine. Vol. /, (January 2009.): /-.

Duan, W., Gao, L., SU, X., Wang, L., Nana-Sinkam, P., Otterson, G.A., Villalona-Calero, M.A.. "MicroRNA-34a is an important component of PRIMA-1 induced apoptotic network in human lung cancer cells." International Journal of Cancer. Vol. /, (January 2009.): /-.

Crawford, M; Batte, K; Yu, L; Wu, X; Nuovo, GJ; Marsh, CB; Otterson, GA; Nana-Sinkam, SP. "MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 388, no. 3. (October 2009.): 483-489.

Nana-Sinkam,SP; Croce,CM. "MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application." CANCER GENETICS AND CYTOGENETICS. Vol. 203, no. 2. (December 2010.): 127-133.

Yan, F; Wu, X; Crawford, M; Duan, W; Wilding, EE; Gao, L; Nana-Sinkam, SP; Villalona-Calero, MA; Baiocchi, RA; Otterson, GA. "The search for an optimal DNA, RNA, and protein detection by in situ hybridization, immunohistochemistry, and solution-based methods." METHODS. Vol. 52, no. 4. (December 2010.): 281-286.

Nana-Sinkam,SP; Croce,CM. "MicroRNA dysregulation in cancer: Opportunities for the development of microRNA-based drugs." IDRUGS. Vol. 13, no. 12. (December 2010.): 843-846.

Bertino,E,M; Otterson,G,A; Villalona-Calero,M,A; Nana-Sinkam,S,P; GHANY,A,M; Donthireddy,K,R; Karim,N,FAbdel; Cantrell,S; Phillips,G,S. "Phase II trial of nab-paclitaxel plus carboplatin for advanced NSCLC in patients at risk of bleeding from VEGF-directed therapies." JOURNAL OF CLINICAL ONCOLOGY. Vol. 28, no. 15. (May 2010.): /-.

Nana-Sinkam, SP, Vachani. "Searching for the Elusive Biomarker in Lung Cancer: Where Should We Look?." Cancer Biology and Therapy. Vol. 3, (August 2010.): 273-5.

Duan, W; Gao, L; Wu, X; Wang, L; Nana-Sinkam, SP; Otterson, GA; Villalona-Calero, MA. "MicroRNA-34a is an important component of PRIMA-1-induced apoptotic network in human lung cancer cells." INTERNATIONAL JOURNAL OF CANCER. Vol. 127, no. 2. (July 2010.): 313-320.

Zimmerman,EI; Dollins,CM; Crawford,M; Grant,S; Nana-Sinkam,SP; Richards,KL; Hammond,SM; Graves,LM. "Lyn Kinase-Dependent Regulation of miR181 and Myeloid Cell Leukemia-1 Expression: Implications for Drug Resistance in Myelogenous Leukemia." MOLECULAR PHARMACOLOGY. Vol. 78, no. 5. (November 2010.): 811-817.

Nana-Sinkam, SP; Fabbri, M; Croce, CM. "MicroRNA in cancer: Personalizing diagnosis and therapy." Annals of New York Academy of Sciences. Vol. 1210, no. 1. (October 2010.): 25-33.

Nana-Sinkam, SP; Croce, CM. "MircoRNA deregulation in cancer: Opportunities for the development of miroRNA-based drugs." Drugs. Vol. ., (January 2010.): .-.

Nana-Sinkam, SP. ".." Lung Cancer Frontiers. Vol. ., no. 39. (January 2010.): 5-8.

Huang,Y; Crawford,M; Nana-Sinkam,SP; Ghadiali,SN. "Role Of Micro-RNAs In Regulating Mechanically Induced Inflammation In Human Small Airway Epithelial Cells." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 183, (January 2011.): /-.

Kotha, SR, Piper, MG, Patel, RB, Sliman, S, Malireddy, S, Baran, CP, Nana-Sinkam, SP, Wewers, MD, Romberger, D, Marsh, CB, Parinandi, NL. "Phospholipase A2 Activation by poultry Particulate Matter is Mediated Through Extracellular Signal-Regulated Kinase in Lung Epithelial Cells: Regulation of Interleukin-8 Release." Cell Biochem Biophys. Vol. /, (December 2011.): .-.

Ezzie, ME, Chacey, M, Nana-Sinkam, Sp. "Non-Coding RNAs as Biomarkers for Lung Cancer." Lung Cancer Frontiers. Vol. /, (January 2011.): /-.

Wu,Yun; Crawford,Melissa; Yu,Bo; Mao,Yicheng; Nana-Sinkam,Serge,P; Lee,L,James. "MicroRNA Delivery by Cationic Lipoplexes for Lung Cancer Therapy." MOLECULAR PHARMACEUTICS. Vol. 8, no. 4. (July 2011.): 1381-1389.

Napolitano,J,R; Liu,M; Bao,S; Crawford,M; Cormet-Boyaka,E; Nana-Sinkam,P; Knoell,D. "Cadmium-Induced Lung Epithelial Cell Toxicity Is Mediated Through NF-kappaB Dependent Zip8 Transport." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 183, (January 2011.): /-.

Nana-Sinkam, SP, Croce, CM. "Non-Coding RNAs in Cancer Initiation and Prgoression and as Novel Biomarkers." Mol. Onol.. Vol. 6, (December 2011.): 483-91.

Crouser,E,D; Julian,M; Shao,G; Crawford,M; Culver,D,A; Nana-Sinkam,P. "MicroRNA Targets The Neopterin Pathway In Pulmonary Sarcoidosis." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 183, (January 2011.): /-.

Nana-Sinkam, SP; Crouser, ED.. "Altered Immune Surveillance: A common Link Between Cancer and Sepsis?." Critical Care Medicine. Vol. 38, no. 3. (January 2011.): 1000-1001.

Nana-Sinkam, SP; and Croce, CM. "microRNA as therapeutic targets in cancer." Translational Research. Vol. 157, no. 4. (April 2011.): 216-225.

Ezzie, ME; Crawford, M; Cho, J; Orellana, R; Zhang, S; Gelina, R; Batte, K; Yu, L; Nuovo, G; Galas, D; Diaz, PT; Wang, K; Nana-Sinkam, SP. "Gene expression networks in COPD: microRNA and mRNA regulation." Thorax. Vol. 67, (September 2011.): 122-131.

Otterson, GA; Nana-Sinkam, SP; Crawford, M; Bertino, E; Villalona-Calero, MA; Rahmani, M; Symmes, C; Phillips, GS; Wu, X; Yu, L. "Blood Based Mirna Analysis From A Phase 2 Trial Of Nab-paclitaxel Plus Carboplatin For Advanced NSCLC In Patients Ineligible For Bevacizumab." JOURNAL OF THORACIC ONCOLOGY. Vol. 7, no. 9. (September 2012.): S285-S285.

Hassan, F; Nuovo, GJ; Crawford, M; Boyaka, PN; Kirkby, S; Nana-Sinkam, SP; Cormet-Boyaka, E. "MiR-101 and miR-144 Regulate the Expression of the CFTR Chloride Channel in the Lung." PLOS ONE. Vol. 7, no. 11. (November 2012.): e50837-.

Crouser, ED; Julian, MW; Crawford, M; Shao, G; Yu, L; Planck, SR; Rosenbaum, JT; Nana-Sinkam, SP. "Differential expression of microRNA and predicted targets in pulmonary sarcoidosis." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 417, no. 2. (January 2012.): 886-891.

Fabbri, M, Paone, A, Calore, F, Galli, R, Gaudio, E, Santhanam, R, Lovat, F, Zanesi, N, Crawford, M, Ozer, G, Wernicke-Jameson, D, Alder, H, Nana-Sinkam,SP, Perrottie, D, Croce, CM. "MicroRNAs Bind to Toll-Like Receptors to Induce Prometastaic Inflammatory Response." Proc Natl Acad Sci USA. Vol. 31, (July 2012.): E2110-6.

Huang, Y, Crawford, M, Higuita-Castro, N, Nana-Sinkam, SP, Ghadiali, SN. "miR-146 Regulates Mechanotransduction and Pressure-Induced Inflammation in Small Airway Epithelium." Faseb J. Vol. 8, (August 2012.): 3351-64.

Spira, A, Nana-Sinkam, SP. "Using microRNAs to Inform Clinical Decision Making in Lung Cancer: Ready for Primetime?." Am J Respir Crit Care Med. Vol. 186, (December 2012.): 1077-9.

Peng, Y; Dai, Y; Hitchcock, C; Yang, X; Kassis, ES; Liu, L; Luo, Z; Sun, Hui-Lung; Cui, Ri; Wei, H; Kim, T; Lee, TJ; Jeon, Young-Jun; Nuovo, GJ; Volinia, S; He, Q; Yu, J; Nana-Sinkam, SP; Croce, CM. "Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 110, no. 37. (September 2013.): 15043-15048.

Kotha, SR; Piper, MG; Patel, RB; Sliman, S; Malireddy, S; Zhao, L; Baran, CP; Nana-Sinkam, SP; Wewers, MD; Romberger, D; Marsh, CB; Parinandi, NL. "Phospholipase A(2) Activation by Poultry Particulate Matter is Mediated Through Extracellular Signal-Regulated Kinase in Lung Epithelial Cells: Regulation of Interleukin-8 Release." CELL BIOCHEMISTRY AND BIOPHYSICS. Vol. 67, no. 2. (November 2013.): 415-429.

Nana-Sinkam,SP; Powell,CA. "Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.." Chest. Vol. 143, no. 5. (May 2013.): e30S-9S.

Nana-Sinkam, SP; Croce, CM. "Clinical Applications for microRNAs in Cancer." CLINICAL PHARMACOLOGY & THERAPEUTICS. Vol. 93, no. 1. (January 2013.): 98-104.

Kang, Hye-Won; Crawford, M; Fabbri, M; Nuovo, G; Garofalo, M; Nana-Sinkam, SP; Friedman, A. "A Mathematical Model for MicroRNA in Lung Cancer." PLOS ONE. Vol. 8, no. 1. (January 2013.): e53663-.

Garofalo, M; Jeon, Young-Jun; Nuovo, GJ; Middleton, J; Secchiero, P; Joshi, P; Alder, H; Nazaryan, N; Di Leva, G; Romano, G; Crawford, M; Nana-Sinkam, SP; Croce, CM. "MiR-34a/c-Dependent PDGFR-alpha/beta Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer." PLOS ONE. Vol. 8, no. 6. (June 2013.): e67581-.

Wu, Y; Terp, MC; Kwak ,KJ; Gallego-Perez, D; Nana-Sinkam, SP; Lee, LJ. "Surface-Mediated Nucleic Acid Delivery by Lipoplexes Prepared in Microwell Arrays." SMALL. Vol. 9, no. 13. (July 2013.): 2358-2367.

Acunzo, M; Romano, G; Palmieri, D; Lagana, A; Garofalo, M; Balatti, V; Drusco, A; Chiariello, M; Nana-Sinkam, SP; Croce, CM. "Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 110, no. 21. (May 2013.): 8573-8578.

Powell, CA; Halmos, B; Nana-Sinkam, SP. "Update in Lung Cancer and Mesothelioma 2012." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 188, no. 2. (July 2013.): 157-166.

Wu, Y; Crawford, M; Mao, Y; Lee, RJ; Davis, IC; Elton, TS; Lee, LJ; Nana-Sinkam, SP. "Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer." MOLECULAR THERAPY-NUCLEIC ACIDS. Vol. 2, (April 2013.): e84-.

Wu, Y; Kwak, KJ; Agarwal, K; Marras, A; Wang, C; Mao, Y; Huang, X; Ma, J; Yu, B; Lee, R; Vachani, A; Marcucci, G; Byrd, JC; Muthusamy, N; Otterson, G; Huang, K; Castro, CE; Paulaitis, M; Nana-Sinkam, SP; Lee, LJ. "Detection of Extracellular RNAs in Cancer and Viral Infection via Tethered Cationic Lipoplex Nanoparticles Containing Molecular Beacons." ANALYTICAL CHEMISTRY. Vol. 85, no. 23. (December 2013.): 11265-11274.

Dakhlallah, D, Batte, K, Want, Y, Yan, P, Nuovo, G, Nana-Sinkam, SP, Piper, M, Marsh, CB. "Epigenetic Regulation of miR-17 similar to 92 Contributes to the Pathogenesis of Pulmonary Fibrosis." Am J Respir Crit Care Med. Vol. 187, no. 4. (February 2013.): 397-405.

Jeon,Young-Jun; Nuovo,Gerard,J; Midddleton,Justin; Joshi,Pooja; Nazaryan,Natalya; Di Leva,Gianpiero; Romano,Giulia; Crawford,Melissa; Nana-Sinkam,Patrick; Garofalo,Michela; Croce,Carlo,M. "MiR-34a/c-dependent PDGFR-alpha/beta reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer.." CANCER RESEARCH. Vol. 73, no. 8. (April 2013.): /-.

Nana-Sinkam,Serge,Patrick; Powell,Charles,A. "Molecular Biology of Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines." CHEST. Vol. 143, no. 5. (May 2013.): E30-E39.

Brown, D; Rahman, M; Nana-Sinkam, SP. "MicroRNAs in respiratory disease. A clinician's overview.." Annals of the American Thoracic Society. Vol. 11, no. 8. (October 2014.): 1277-1285.

Nana-Sinkam, SP; Croce, CM. "MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use." GENOME BIOLOGY. Vol. 15, no. 9. (January 2014.): 445-.

Rahman, M; Lovat, F; Romano, G; Calore, F; Acunzo, M; Bell, EH; Nana-Sinkam, SP. "miR-15b/16-2 Regulates Factors That Promote p53 Phosphorylation and Augments the DNA Damage Response following Radiation in the Lung." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 289, no. 38. (September 2014.): 26406-26416.

Nana-Sinkam,S,Patrick; Choi,Augustine,MK. "Epigenetics and the Unfolded Protein Response in the Lung: Emerging Role for MicroRNAs." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 189, no. 3. (February 2014.): 239-240.

Wu, Y; Ma, J; Woods, PS; Chesarino, NM; Liu, C; Lee, LJ; Nana-Sinkam, SP; Davis, IC. "Selective targeting of alveolar type II respiratory epithelial cells by anti-surfactant protein-C antibody-conjugated lipoplexes." JOURNAL OF CONTROLLED RELEASE. Vol. 203, (April 2015.): 140-149.

Rivas-Perez, H; Nana-Sinkam, SP. "Integrating pulmonary rehabilitation into the multidisciplinary management of lung cancer: A review." RESPIRATORY MEDICINE. Vol. 109, no. 4. (April 2015.): 437-442.

Healy, WJ; Peters, S; Nana-Sinkam, SP. "A middle-aged man presenting with unexplained mucosal erosions and progressive dyspnoea.." BMJ case reports. Vol. 2015, (January 2015.): /-.

Barger,Jennifer,F; Nana-Sinkam,S,Patrick. "MicroRNA as tools and therapeutics in lung cancer." RESPIRATORY MEDICINE. Vol. 109, no. 7. (July 2015.): 803-812.

Kalvala, A, Gao, L, Aguila, B, Dotts, K, Rahman, M, Nana-SInkam, SP, Otterson, G, Villalona-Calero, M, Duan, W. "Rad51C-ATXN7 Fusion Gene Expression in Colorectal Tumors." /. -.

Bertino, E, Vilallona-Calero, M, Nana-Sinkam, SP, Cantrell, S, Rahmani, M, Symmes, C, Phillips, G, Otterson, G. "Phase II Trial of NAB-Paclitaxel Plus Carboplatin for Advanced NSCLC for Patients at Risk of Bleeding from VEGF Directed Therapies.." Lung Cancer. -.

Baldwin, S, Deighan, C, Kwang, K, Rahman, M, Nana-SInkam, SP, Lee, LJ, Paulaitis, ME. "miRNA Cargo in Microvesicles Released by A549 Cells in Sparse and Unevenly Distributed." /. -.

Rahman, M, Nana-Sinkam, SP. "Extracellular Biology of Lung Disease." Biochemistry and Cell Biology. -.

Rahman, M, Lovat, F, Otterson, G, Dikov, M, Nana-Sinkam, SP. "Exomsomes Drive EMT in Human Lung Cacner Metastasis: Impact on Vimentin." /. -.

Paone, A, Lovat, F, Calore, F, Galli, R, Fabbri, M, Zanesi, P, Carasi, S, Valeri, N, Bruss, M, RIaz, S, Romano, G, Crawford, M, Nana-Sinkam, SP,Croce, C. "GW4869 Inhibits Microvesicle-Mediated Promotion of Cancer Invasiveness and Angiogenesis." /. -.

Wu, X, Yan, F, Duan, W, Gao, L, Crawford, M, Nuovo, GJ, Lawler, S, Villalona-Calero, M, Nana-Sinkam, SP, Otterson, M. "miR-205 Affects Oncogenic Pathways in Lung Cancer." Lung Cancer. -.

Wood, Karen, Nana-Sinkam, SP, Ferketich, A, King, M, Horne, A, Yang, S, WU, H, Diaz, P. "Proteomic Differences in Albeolar Macrophages Among HIV-INfected Subjects with Emphysema." COPD. -.

Hoover, ME, Rahman, M, Freitas, MA, Nana-SInkam, SP. "Comparison of PUrification Techniques for Shotgun Proteomic Analysis of Human Extracellular Vesicles." Proteomics. -.

Fleming, J, Nana-Sinakm, SP. "MicroRNAs as Tools and Targets for Lung Cancer." Respiratory Medicine. -.

Pulliero, A, Prieto, A, Wu, Y, Fenoglio, D, Parodi, A, Soares, C, Filaci, G, Lee, L, Nana-Sinkam, SP, Izzotti, A. "Nanoparticles Increase the Efficacy of Cancer Chemopreventive Agents in Cells Exposed to Cigarette Smoke Condensate." Carcinogenesis. -.

Vannini,I, Challagundla, KB, Plousiou, M, Paliaga, G, Fanini, F, Crawford, M, Ferracin, M, Davuluri, R, Zhihi, G, Cortez, M, Ivan, C, Wise, P, Carloni, S, Ling, H, Murtadha, M, Gitlitz, B, Laird-Offringa, A, Nana-Sinkam, SP, Negrini, M, Amadori, D, Cimmino, A, Calin, G, Fabbri, M. "Ultraconserved Region 339 Promotes Carcinogenesis by Sequestering tumor Supressor miroRNAs." Nature Communications. -.

Nana-Sinkam, SP; Croce, CM. "Noncoding RNAs in cancer initiation and progression and as novel biomarkers." Molecular Oncology. -.

Kotha SR; Piper MG; Patel RB; Sliman, S; Malireddy, S; Baran CP; Nana-Sinkam SP; Wewers MD; Romberger, D; Marsh, CB; Parinandi, NL. "Phospholipase A2 activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: Regulation of interleukin-8 release.." Cell Biochem Biophys. -.

 

Reference Works

December 2002 Nana-Sinkam, SP, Bost, T, Sippel, J."Unilateral Pulmonary Edema in a 29-Year Old Male Visiting Altitude" /.
January 2004 Nana-Sinkam, P, Golpon, H., Keith,RL., Moore,MD., Voelkel,N.F., Nemenoff,RA., Franklin,W., Geraci, MW."A Role for Prostacyclin in Human Non-Small Cell Lung Cancers" /.
December 2004 Gruber, MP, Nana-Sinkam, SP, Chan, ED."Airflow Limitation and Dynamic Gas Trapping in a Bone Marrow Transplant Recipient" /.
December 2005 Nana-Sinkam, SP; Oyer, RJ; Stearman, RS, Sotto-Santiago, S; Moore, MD; Bull, TM; Grady,MC; Choudhery, Q; Nemenoff , RA; Lane, K; Loyd, JE; Geraci, MW."Prostacyclin Synthase Promoter Regulation and Familial Pulmonary Hypertension" /.
December 2005 Bull, TM; Coldren, C; Nana-Sinkam, P; Sotto-Santiago, SM;Moore, M; Voekel, NF; Geraci, MW.."Microarray Analysis of Peripheral Blood Cells in Pulmonary Arterial Hypertension, Surrogate to Biopsy" /. : 584S
January 2005 Lee, JD; Nana-Sinkam, P; Sakao, S; Taraseviciene-Stewart, L; Geraci, MW; Voelkel, NF."Cigarette Smoke Extract (CSE) Decreases Prostacyclin Synthase Gene Expression in Pulmonary Microvascular Endothelial Cells." /.
January 2005 Lee, JD; Nana-Sinkam, P; Sakao,S; Taraseviciene-Stewart, L; Geraci, MW; Voelkel, NF."Effects of Iloprost on VEGF, Prostacyclin Synthase (PGI2-S) and Prostacyclin Receptor (PGI2-R) Gene Expression in Pulmonary Microvascular Endothelial Cells." /.
August 2006 Nana-Sinkam,SP., Stearman, RS, Lee JD, Sakao,S., Sotto-Santiago,S., Voelkel,NF., Geraci,MW.."Prostacyclin Synthase in Smoking Related Lung Disease" /. : 517
January 2008 Nana-Sinkam, SP; Lee, JD; Sotto-Santiago, S; Steraman, RS; Choudhery, Q; Keith, RL; Voelkel, NF; Geraci, MW."Prostacyclin Prevents Cigarette Smoke Induced Endothelial Apoptosis" /.
September 2008 Hollyfield, J; Gavrilin, M; Nana-Sinkam, P; Wewers, M; Exline, M.."Smokin' ICE: Cigarette Smoke Extract Suppresses Inflammasome in Peripheral Blood Monocytes Production" /.
January 2008 Crawford, M., Brawner, E., YU, L., Otterson, GA., Nuovo, GJ., Nana-Sinkam, SP.."MicroRNA 126 as a Tumor Suppressor in Non Small Cell Lung Cancer" /.
March 2008 Young, RL, Mitchell, JD, Cool, C, Nana-Sinkam, SP."Wheezing and Exertional Dyspnea in a 25 Year Old Mountaineer" /.
January 2009 Exline, Matthew; Hollyfield, Jennifer; Gavrilin, Mikhail; Nana-Sinkam, Pat; Wewers, Mark."Cigarette Smoke Extract Suppresses Inflammasome in Peripheral Blood Monocytes" /.
January 2009 Xin Wu, Fengting Yan, Wenrui Duan, Li Gao, Melissa Crawford, Gerard J. Nuovo, Sean Lawler, S. Patrick Nana-Sinkam, Miguel A. Villalona, Gregory A. Otterson."MicroRNA miR205 enhances cisplatin-induced apoptosis in lung cancer cells" /.
January 2009 M.Crawford , K. Batte , L. Yu PhD , X. Wu ,G.A. Otterson MD and S. P. Nana-Sinkam MD."MicroRNA 133B Sensitizes Non Small Cell Lung Cancer to Chemotherapeutic Agents by Direct Targeting of BCLw" .
January 2009 M E Ezzie, MD, L Yu, PhD, K Batte, M Crawford, P T Diaz, MD and S P Nana-Sinkam, MD."A Distinct MicroRNA Profile Distinguishes GOLD stages in COPD" .
January 2010 Kotha, Sainath R.; Crawford, Melissa; Parinandi, Narasimham L; Nana-Sinkam, S. Patrick."Prostacyclin Offers Cytoprotection Against Camtothecin-Induced Apoptosis by MCL1 Induction in Human Lung Endothelial Cells" /.
January 2010 Huang, Yan; Crawford, Melissa; Nana-Sinkam, Patrick and Ghadiali, Samir."Role of MicroRNAs in regulating mechanically induced inflammation in Human Alveolar Epithelial Cells" /.
January 2010 B. Pronold, M. Asif, S.P. Nana-Sinkam."The dreaded consequence of TNF-a inhibitors" /.
October 2010 Sood, Namita; Crawford, Melissa; Batte, Kara; Wright, Valerie and Nana-Sinkam, S. Patrick."Circulating MicroRNA in the Pathogenesis of Pulmonary Hypertension" /.
January 2010 Zimmerman, E.I., Dollins, C.M., Crawford, M., Nana-Sinkam, S.P.,Hammond, S., Graves, L.M.."MiR181b Regulates Mcl-1 Expression in Lyn-Dependent Imatinib-Resistant" /.
May 2010 Nana-Sinkam, SP, Croce, CM."MircoRNAs in Diagnosis and PRognosis in Cancer: What Does the Future Hold?" /.
January 2010 Bruce, J, Goodman,B, Ross, PR, Hitchcock, C, Nana-Sinkam, SP."Reactive Lymphoid Hyperplasia- A Case of Castleman's Disease" /.
January 2010 Willey, J.C; Blomquist, T.; Kern, J.A.; Massion, P.P.; Nana-Sinkam, P.; Jett, J.R.; Kvale, P.A.; Midthun, D.E.; Johnson, C.; Levin, A.; Crawford, E.L.; Lazaridis, N.; Anders, J.; Austemiller, B.."Multi-Institutional Trial of A Lung Cancer Risk Test" /.
January 2011 Yan Huang, Melissa Crawford, Natalia Higuita-Castro, Patrick Nana-Sinkam, Samir Ghadiali."Regulation of Mechanotransduction and Inflammation by miR-146a in Primary Lung Epithelial Cells" /.
January 2011 J. Napolitano, M. Liu, S. Bao, E. Cormet-Boyaka,E., M. Crawford, S.P. Nana-Sinkam, D. Knoell."Cadmium-Induced Lung Epithelial Cell Toxicity Is Mediated Through NF-κB Dependent Zip8 Transport" /.
January 2011 Ahmad Malas, Jarrod Bruce, Patrick Nana-Sinkam."Diuretic-refractory flash pulmonary edema: a case of subacute Gemcitabine-induced pulmonary toxicity" /.
January 2011 S.N. Ghadiali, Y. Huang, M. Crawford, P. Nana-Sinkam."Role Of Micro-RNAs In Regulating Mechanically Induced Inflammation In Human Small Airway Epithelial Cells" /.
January 2011 Crouser, E.D., Julian M.W., Shao, G., Crawford, M., Culver, D.A., Nana-Sinkam, S.P.."MicroRNA Targets the Neopterin Pathway in Pulmonary Sarcoidosis." /.
May 2011 Cormet-Boyaka, E; Nuovo, G; Hassan, F; Crawford, M; Diaz, PT; Nana-Sinkam, SP."Identification of Two miRNAs That Regulate The CFTR Chloride Channel And Are Overexpressed In The Lung Of Patients With Severe COPD" Denver.
June 2011 Nana-Sinkam, SP, Piper, M."miR-126 (microRNA 126)" /.
January 2011 Gregory A. Otterson MD, Erin M. Bertino MD, Nagla A Karim MD, Kavitha Donthireddy MD, Ahmed M. Ghany MD, Robert Rupert MD, Sarah Cantrell, Meliha Rahmani, Melinda Lynn, S. Patrick Nana-Sinkam MD, Gary S. Phillips, Miguel A. Villalona-Calero MD."Phase II Trial of nab-paclitaxel plus carboplatin in patients with advanced NSCLC at risk of bleeding from VEGF directed therapies" /.
January 2011 Piper, MG, Sweet, K, Marsh, CB, Nana-Sinkam, SP."Research Highlights" /.
January 2012 Wu, Y; Kwak, KJ; Ma, J; Mao, Y; Crawford, M; Wang, X; He, H; Lee, A; Nana-Sinkam, PS; Lee, JL."Capture And Detection Of Circulating Tumor Cells And Exosomes Using Tethered Lipoplex NanoParticles For Lung Cancer Diagnosis and Surveillance" /.
January 2012 Wu, Y; Crawford, M; Lee, J; Nana-Sinkam, SP;."MicroRNA-29b Delivery Via EpCam Targeted Cationic Lipoplexes In Lung Cancer Treatment" /.
January 2012 Wu, X; Yan, F; Duan, W; Gao, L; Crawford, M; Nana-Sinkam, SP; Villalona-Calero, M; Otterson, G."Global miRNA Expression Changes Induced by HDAC-42 and 5-azaCdr in Lung Cancer Cells" /.
January 2012 Nana-Sinkam, SP; Crawford, M; Wu, X; Bertino, EM; Villalona-Calero, MA; Cantrell, S; Rahmani, M; Symmes, C; Phillips, GS; Yu, L; Otterson, GA."Blood Based miRNA Analysis From A Phase 2 Trial of nab-Paclitaxel Plus Carboplatin For Advanced NSCLC In Patients Ineligible For Bevacizumab" /.
February 2012 Kang, H; Nana-Sinkam, SP; Friedman, A."A Mathematical Model for miR-9, Let; 7 and EMT In Lung Cancer" Columbus.
May 2012 Wu,Y, Duan, W, Otterson, GA, Lee, LJ."Research Highlights" /.
January 2013 Mukku, S, Nana-Sinkam, SP."Persistent Dypsnea in a Patient with Down Syndrome, American Thoracic Society Web Case" /.
January 2013 Araujo, L, Bissonnette, A, Carbone, DP, Nana-Sinkam, SP."Genomics to Clinical Practice in Lung Cancer, Research Highlights" /.
January 2013 Safi, F; Lu, M; Levin, AM; Massion, PP; Midthun, DE; Nana-Sinkam, SP; Arenberg, DA; Musani, AI; Mazzone, PJ; Nathan, S; Wainz, R; Silvestri, GA; Willey, JC;."Demographic Characteristics Of Subjects Recruited For Lung Cancer And COPD Risk Test Validation" /.
January 2013 Rivas Perez, H, Nana-Sinkam, SP."Selections from the Peer-Reviewed Literature" /.
January 2014 Wu, Y; Kwak, KJ; Ma, J; Mao, Y; Wang, X; He, H, Rahaman, M; Lee, A; Lee, LJ; Nana-Sinkam, SP."Nanoengineering microRNA In Lung Cancer Diagnosis And Therapy" /.
January 2014 Ghadiali, SN; Nelson, K; Bobba, C; Nana-Sinkam, SP; Zhao, X; Whitson, B."MicroRNAs As Novel Regulators Of Mechanotransduction And Lung Injury/Inflammation" /.
January 2014 Davis, IC; Schermerhorn, LD; Woods, PS; Nana-Sinkam, SP."Impact of Infection With Influenza A/W/SN/33 (H1N1) Virus onmiRNA Expression Profiles Of Murine Alveolar Type II Cells" /.
January 2014 Shukla, V; Higuita-Castro, N; Nana-Sinkam, SP; Ghadiali, S."Impact of Lung Biomechanics On Tumor Metastasis" /.
January 2014 Rivas-Perez, H, Carbone, DP, Nana-Sinkam."Novel Biomarkers in Lung Cancer, Research Highlights" /.
January 2014 Rahman, M; Lovat, F; Romano, G; Acunzo, M; Bell, E; Nana-Sinkam, SP."miR-15b Induces DNA Repair In The Lung Following Irradiation" /.
January 2014 Barger, JF; Kaufman, JM; Carbone, DP; Nana-Sinkam, Sp."Identification of miRNA Dysregulation Associated With LKB1 Loss" /.
January 2014 Hoover, ME; Rahman, M; Freitas, MA; Nana-Sinkam, SP."Purification Techniques For Shotgun Proteomic Analysis Of Extracellular Serum Vesicles" /.
Washburn RG, Nana-Sinkam P, Bruggeman LA, Klotman PE."HIV Transgenic Model for Disseminated Cryptococcosis" .
Nana-Sinkam P, Golpon H, Keith RL, Moore MD, Voelkel NF, Franklin W, Miller YE, Nemenoff RA, Geraci MW."Prostacyclin Synthase in Human Non-Small Lung Cancers and Regulatory Mechanisms" .
Kotha,S; Hunter,M; Sliman,S; Baran,C; Cruff J; Kuppusamy,M; Sherwani,S; Malireddy,S; Magalang U; Nana-Sinkam,P; Wewers,M; Marsh,C; Parinandi, N.."Mechanism of Agricultural Respiratory Diseases: Phospholipase A2 Activation Mediates Poultry PM-Induced Inflammatory Cytokine Release Through Modulation by Extracellular Signal-Regulated Kinase In Lung Epithelial Cells" .
Mihai, C., Huang, Y., Crawford, M., Nana-Sinkam, S.P., Ghadiali, S.."Biomechanical Characterization of Chemical and microRNA Therapeutics in Lung Cancer" .
Bertino, E.M., Otterson, G.A., Villalona-Calero, M.A., Nana-Sinkam, S.P., Ghany, A.M., Donthireddy, K.R., Abdel Karim, N.F., Cantrell, S., Phillips, G.S.,."Phase II Trial of Nab-Paclitaxel Plus Carboplatin for Advanced NSCLC in patients at Risk of Bleeding from VEGF-Directed Therapies" .

Inventions and Patents

Nana-Sinkam, SP; Marsh, CB; Otterson, GA; Hunter, MG.. "MicroRNA Expression Profiling in the Peripheral Blood in Lung Cancer." Filed November 2007.

Nana-Sinkam, SP, Ezzie, ME, Diaz, P. ""MicroRNA Expression Profiling and Targeting in Chronic Obstructive Pulmonary Disease Lung Tissue"." Filed December 2008.

Nana-Sinkam, SP; Geraci, MG; Keith, RL. "Treatment of COPD." Filed December 2007.

 

Presentations

"Prostcyclin Synthase in Human Non-Small Cell Carcinoma." Presented at World Congress on Lung Cancer, Vancouver, CA|CAN. (January 2003)

"Prostacyclin in Lung Cancer: Mechanisms of Chemoprevention." Presented at Division of Pulmonary Sciences and Critical Care Medicine Research in Progress, University of Colorado Health Sciences, CO. (March 2003)

"Pulmonary Complications of Radiation/Chemotherapy." Presented at University of Colorado School of Medicine Thoracic Oncology Symposium, Avon, CO. (September 2004)

"A Role for Prostacyclin in Human Non-Small Lung Cancers." Presented at Thomas L. Petty Aspen Lung Conference, Aspen, CO. (January 2004)

"Respiratory Conditions: What Tests are Needed and Why." Presented at University of Colorado School of Medicine Nursing Practitioner Symposium, Keystone, CO. (July 2004)

"Why Go Into Pulmonary Medicine." Presented at University of Colorado School of Medicine SNMA Career Night, CO. (April 2005)

"Prostacyclin Synthase Promoter Regulation and Familial Pulmonary Hypertension." Presented at Thomas L. Petty Aspen Lung Conference, Aspen, CO. (June 2005)

"Optimizing Pulmonary Function in the Lung Cancer Patient." Presented at University of Colorado School of Medicine, Thoracic Oncology Symposium, Denver, CO. (September 2005)

"Regulation of Prostacyclin in Smoking Related Lung Disease." Presented at University of Colorado SPORE Meeting, CO. (October 2005)

"Prostacyclin Prevents Cigarette Smoke Induced Endothelial Apoptosis." Presented at American Society of Clinical Investigation, Chicago, IL. (June 2006)

"Prostacyclin in Smoking Related Lung Disease." Presented at Leone Lab Meeting, CO. (September 2006)

"Tumor Microenvironment: New insights into Lung Cancer Development and Metastasis." Presented at American Thoracic Society International meeting, San Francisco, CA. (May 2007)

"The Potential for MicroRNAs as Biomarkers in Lung Cancer." Presented at University of Pennsylvania Pulmonary Research Conference, Philadelphia, PA. (December 2007)

"Lung Cancer Staging in 2007." Presented at American Thoracic Society Internation Meeting Sunrise Seminar, . (May 2007)

"Cancer Cases." Presented at American College of Chest Physicians Meeting, Chicago, IL. (October 2007)

"The Potential Role for MicroRNA-126 as a Biomarker in Lung Cancer." Presented at National Jewish Health Research Conference, Denver, CO. (November 2008)

"Minority Faculty Development Seminar." Presented at AAMC Conference, Alexandria, VA. (September 2008)

"Novel Biomarkers of Lung Cancer. Diagnosis and Prognosis." Presented at American Thoracic Society International Meeting Symposium, Toronto. (May 2008)

"microRNAs in Lung Disease, Sunrise Seminar." Presented at American Thoracic Society International Meeting, Toronto. (May 2008)

"Emerging Role for MicroRNAs as Biomarkers in Lung Cancer." Presented at American Thoracic Society International Meeting, Toronto, CA|CAN. (May 2008)

"MicroRNAs in Lung Cancer: A Needle in a Haystack." Presented at Institute for Systems Biology Research Conference, . (December 2008)

"Risky Business: The Clinical and Scientific Basis for Lung Cancer Risk Assessment." Presented at American Thoracic Society International Meeting Post Graduate Course, San Diego, CA. (May 2009)

"microRNAs and the Hallmarks of Cancer." Presented at American Thoarcic Society International Conference, San Diego, CA. (May 2009)

"Micro(RNA) Managing Lung Disease." Presented at American Thoracic Society International Meeting Scientific Symposium, San Diego, CA. (May 2009)

"MicroRNAs as Therapeutic Targets in Lung Cancer." Presented at Research Conference, University of Pennsylvania, Institutes for Environmental Medicine, . (December 2009)

"Targeting miRNA in Smoking Related Lung Disease." Presented at Research Seminar, Cleveland, OH. (January 2010)

"MicroRNA in the Pathogenesis of Lung Disease." Presented at American Thoracic Society International Meeting, New Orleans, LA. (May 2010)

"Links to Airways Disease and Cancer." Presented at American Thoracic Society International Meeting, New Orleans, LA. (May 2010)

"Advances in Lung Cancer Diagnosis and Treatment." Presented at American Thoracic Society International Meeting: Poster Discussion, New Orleans, LA. (May 2010)

"MicroRNA in Smoking Related Lung Disease." Presented at Micromanaging the Lung, Bad Nauheim, DE|DEU. (May 2011)

"Lung Cancer Diagnosis and Staging in 2011." Presented at American College of Physicians, San Juan, PR|PRI. (February 2011)

"Targeting Microrna in Smoking Related Lung Disease." Presented at Cleveland Clinic Genomics Medicine Research Conference, Cleveland, OH. (January 2011)

"Regulating gene Expression:MiRNA, Growth factors." Presented at American Thoracic Society, Denver, CO. (May 2011)

"Omics Approaches to lung disease." Presented at American Thoracic Society, Denver, CO. (May 2011)

"Health Disparities in Lung Cancer, Translational Approaches to Health Disparities in Lung Cancer." Presented at ., . (September 2012)

"miRNA in Smoking Related Lung Disease." Presented at Pulmonary Research Conference, University of Michigan, Ann Arbor, Michigan. (November 2012)

"Translating microRNAs to Clinical Application in Lung Cancer." Presented at Pulmonary and Critical Care Research Seminar, Philadelphia, PA. (December 2013)

"Lung Cancer Early Detection and Staging in 2013." Presented at Midwest EBUS, Advanced Bronchoscopy and percutaneous Tracheostomy Course, Columbus, Ohio. (June 2013)

"ATS Next Top Model for Lung Cancer." Presented at American Thoracic Society International Meeting: Scientific Symposium, Philadelphia, Pennyslvania. (May 2013)

"Midwest Lung Cancer Screen Symposium." Presented at James Comprehensive Cancer Center Screening Program, Plymouth, Michigan. (May 2013)

".." Presented at Breath Deep Lungevity, Newark Ohio, . (May 2013)

"Lung Cancer Screening in 2014." Presented at Ohio Lung Nurse Navigator Network Meeting, Columbus, Ohio. (February 2014)

".." Presented at NCI SPORE Meeting, Washington, DC. (July 2014)

"Pulmonary Rehabilitation in Lung Cancer." Presented at HOPE Summit LUNGevity Foundation, Washington, DC. (May 2014)

"Molecular Insights Into Lung Cancer I." Presented at American Thoracic Society International Meeting, San Diego, CA. (May 2014)

"Co-Chair, Poster Discussion: A view to the Lung: Lung Cancer Screening and the Evaluation of Pulmonary Nodules." Presented at American Thoracic Society International Meeting, San Diego, CA. (May 2014)

"Clinical Year In Review: Lung Cancer." Presented at American Thoracic Society International Meeting, San Diego, CA. (May 2014)

"Old Dog, New Tricks: Advances in Lung Cancer Biology." Presented at American Thoracic Society International Meeting: Mini-Symposium, San Diego, CA. (May 2014)

"Lung Cancer Screening Pro/Con." Presented at American College of Physicians National Meeting, Boston, MA. (April 2015)

"Novel Applications for microRNA in the Diagnosis and Treatment of Lung Cancer." Presented at Computational Medicine Research Seminar, Boston, MA. (June 2015)

 

Professional Activities

present The Ohio State University Medical Center Research Day, Poster Judge.
present The Ohio State University Davis Heart and Lung Research Institute Research Day.
present The Ohio State University College of Medicine Mentor Open House.
1998 - present Stanford Faculty Development Program. University of Michigan Medical Center. Ann Arbor, MI.
2004 - present AACR Molecular Biology in Clinical Oncology. AACR. Aspen, CO.
2005 - present AACR Molecular Biology in Clinical Oncology Workshop. AACR. Aspen, CO.
2006 - present DHLRI Intramural Grants. Ohio State University Medical Center.
2007 - present James CCC Seed Grant. James Cancer Hospital.
2007 - present American Lung Association - Committee Section A. ALA.
2007 - present NetWellness Lung Cancer Discussant. NetWellness.
2007 - present Pulmonary, Allergy, Critical Care and Sleep Medicine Research Day Poster Competition. The Ohio State University. Columbus, OH.
2008 - present Pulmonary, Allergy, Critical Care and Sleep Medicine Morbidity and Mortality. OSU Pulmonary, Allergy, Critical Care and Sleep Medicine. Columbus, OH.
2008 - present Pulmonary, Allergy, Critical Care, and Sleep Medicine Research Day. The Ohio State University. Columbus, OH.
2009 - present Davis Heart and Lung Research Institute Research Day. The Ohio State University. Columbus, OH.
2009 - present Pulmonary, Allergy, Critical Care and Sleep Medicine Research Day Poster Competition. Ohio State University Medical Center. Columbus, OH.
2010 - present Pulmonary, Allergy, Critical Care and Sleep Medicine Research Day. The Ohio State University. Columbus, OH.
2010 - present Pulmonary, Allergy, Critical Care and Sleep Medicine Research Day. The Ohio State University. Columbus, OH.
2010 - present Integrated Diagnostics.
 

Unpublished Works

Kotha, S.R., Salhi, H., Crawford, M., Parinandi, N.L., Nana-Sinkam, S.P.. Prostacyclin Analogues Prevent Endothelial Cell Apoptosis Through cAMP Dependent Induction of MCL1., 2009. January 2011.

Ezzie, M.E., Crawford, M., Batte, K., Wang, K., Galas, D., Marsh, C.B., Diaz, P.T., Nana-Sinkam, S.P.. Gene Expression Networks in COPD: Systems Biology of microRNA and Gene Regulation. January 2011.

Nana-Sinkam,S.P., Piper, M.. MIR126 (microRNA 126). June 2011.

Crawford,M., Drexler,J., Johnson,J., Lannutti,J., Nana-Sinkam,S.P.. Electrospun nanofiber scaffolds alter lung cancer phenotype through deregulated FAK signaling and microRNA. June 2011.

Nana-Sinkam, S.P., Villalona-Calero, M.. Lung Cancer in Cancer Patient Follow-Up: An International Perspective. January 2011.

Nana-Sinkam, S.P. Croce, C.M. microRNAs and Cancer. January 2011.

Wu, X., Yan, F., Duan, W., Gao, L., Crawford, M., Nuovo, G.J., Lawler, S., Nana-Sinkam, S.P., Villalona-Calero, M., Otterson, G.A.. microRNA miR205 Enhances Cisplatin-Induced Apoptosis in Lung Cancer Cells. January 2011.

Crawford, M., Wu, X., Lee, A.V., Nana-Sinkam, S.P.. MicroRNA 126 Regulates NSCLC Chemosensitivity Though IRS-1 Signaling 2009. January 2011.