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Narasimham L. Parinandi, PhD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-8577

Email: parinandi.3@osu.edu

 

Current OSU Appointment

Associate Professor, Pulm,Allergy,Crit Care & Sleep

 

Biographical

Narasimham Parinandi (Pari) is currently an associate professor of internal medicine and pharmacology at the Ohio State University College of Medicine, Columbus, OH, USA. Pari received his PhD in Biology and Toxicology from the University of Toledo, Toledo, OH, USA in 1986 under the tutelage of Prof. Woon Jyung, an authority on zinc metabolism in plants. During doctoral training, Pari specialized in bio-inorganic chemistry and interaction of trace metals with membrane lipids in brain. Pari had undergone post-doctoral training at the Hormel Institute (Mecca of Lipid Research) of the University of Minnesota, Austin, MN in Membrane Lipid Biochemistry and Lipid Oxidation Chemistry from 1986-1990 under the mentorship of Prof. Harald Schmid, a world-renowned expert on plasmalogen and anandamide chemistry. Following that, he was an editor of toxicology and biochemistry and information scientist at the CAS of the American Chemical Society in Columbus, OH, USA. Pari was a junior faculty at the Johns Hopkins University School of Medicine, Baltimore, MD where he worked on oxidant lipid signaling in the division of pulmonary & critical care medicine during 1998-2002 under the mentorships of Prof. Skip Garcia and Prof. V. Natarajan, who are celebrities in vascular endothelial biology and signaling. In 2002, Pari joined the Division of Pulmonary & Critical Care Medicine of the OSU College of Medicine as an assistant professor and has established the Lipid Signaling, Lipidomics, and Vasculotoxicity program at the Davis Heart & Lung Research Institute of the Ohio State University. Pari’s research focus is on Phospholipid Signalases in Lung Vasculature, Lipidomics of Adiposity, and Bioactive Oxidant Lipidomics in Vasculotoxicity. Pari has published over 70 papers in peer-reviewed journals. Pari has been one of the editors of the Journal of Glycomics and Lipidomics. Pari’s passion is to train young scientists, bridging between clinician and basic scientists, and is dedicated to education and training. Pari has trained over 50 young researchers and has been awarded the Outstanding Mentor Awards of the DHLRI and OSU Undergraduate Program.

Advising Narrative

Agriculture/Environmental Science

Books

Kutala, V. K.; Parinandi, N. L.; Khan, M.; Iyyapu, K. M.; Kuppusamy, P.. Spirulina - A Blue-Green Alga with Novel Therapeutic Actions. Houston, TX: Stadium Press, LLC, January 2007.

 

Chapters in Books

Kutala VK, Iyyapu KM, Khan M, Parinandi NL, Kuppusamy PK. "Drug-induced nephrotoxicity protection by Spirulina." In Spirulina in Human Nutrition and Health. Edited by Gershwin E and Belay A. 151-172. Boca Raton, FL: CRC Press, Taylor & Francis Group, January 2007.

Kutual VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. "Spirulina - A Blue-green Alga with Novel Therapeutic Actions." In Recent Progress in Medicinal Plants. Edited by J.N. Govil. Volume 22-. Houston, TX: Stadium Press LLC, January 2007.

Butler S, Mazerik JN, Weis BK, Marsh CB, Schmid HHO, Parinandi NL. "Lipoxygenase-catalyzed phospholipid peroxidation: Preparation, purification and characterization of phosphatidylinositol peroxides." In Free Radicals and Antioxidant Protocols 2nd Edition - Methods in Mol Biol Sseries. -. Totowa, NJ: Humana Press, January 2007.

Steinhour E, Ciapala V, Butler S, Mazerik JN, Cruff JP, Kuppusamy P, Magalang U, Parthasarathy S, Marsh CB, Sen CK, Parinandi NL. "Redox-active antioxidant mudulation of lipid signaling in vascular endothelial cells: Vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase." In Free Radicals and Antioxidant Protocols 2nd ED - Methods in Mol Biol Sseries. Edited by Rao M. Uppu, Subrananyam N. Murthy and William A. Pryor. -. Totowa, NJ: Humana Press, January 2007.

 

Degrees

1980 M.S., Berhampur University

1986 Ph.D., University of Toledo

 

Edited Books

"Free Radicals and Antioxidant Protocols (Methods in Molecular Biology)." Edited by Uppu, R.; Pror, W.; Murthy, S. N.; Parinani, N. L.. Totowa, NJ: Humana Press, January 2010.

 

Editorial Activities

1989 Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
1989 - 1990 Bulletin (Chemical Record) American Chemical Society, Columbus Chapter
2007 Progress of Lipid Research
2007 Antioxidants and Redox Signaling
2007 Lipids
2007 American Journal of Respiratory Cell and Molecular Biology
2007 American Journal of Physiology Cell Biology
2007 Journal of Lipid Research
2007 Chemistry & Physics of Lipids
 

Honors

1975 Bachelor of Science with Honors and Distinction.
1975 - 1977 Post-Graduate Gold Medal Award.
1975 - 1977 National Merit Scholarship. Government of India.
1979 - 1980 Junior Research Fellowship. Council of Scientific and Industrial Research.
1986 Outstanding Teaching Assistant Award. Department of Biology.
1994 - 1996 Recognition. Chemical Abstracts Service, Columbus, Ohio.
1997 - 1998 Recognition-Quality Assurance Program. Chemical Abstracts Service, Columbus, Ohio.
1997 - 1998 Recognition. American Chemical Society, Columbus Chapter.
2009 2009 Distinguished Undergraduate Research Mentor Award. Undergraduate Research Office.
 

Journal Articles

Parinandi NL, Raju PA. "Plant insectides." Science Reporter. Vol. 17(2), (January 1980.): 110-111.

Parinandi NL, Raju PA. "crassulacean plants in aird environment." Science Reporter. (January 1981.): 540-542.

Parinandi, N, L; Weis, B, K; Schmid, H H. "Assay of cardiolipin peroxidation by high-performance liquid chromatography.." Chemistry and physics of lipids. Vol. 49, no. 3. (January 1988.): 215-20.

Parinandi, N, L; Schmid, H H. "Effects of long-chain N-acylethanolamines on lipid peroxidation in cardiac mitochondria.." FEBS letters. Vol. 237, no. 1-2. (January 1988.): 49-52.

Parinandi, N, L; Weis, B, K; Natarajan, V; Schmid, H H. "Peroxidative modification of phospholipids in myocardial membranes.." Archives of biochemistry and biophysics. Vol. 280, no. 1. (January 1990.): 45-52.

Parinandi, N, L; Thompson, E, W; Schmid, H H. "Diabetic heart and kidney exhibit increased resistance to lipid peroxidation.." Biochimica et biophysica acta. Vol. 1047, no. 1. (January 1990.): 63-9.

Parinandi, N, L; Zwizinski, C, W; Schmid, H H. "Free radical-induced alterations of myocardial membrane proteins.." Archives of biochemistry and biophysics. Vol. 289, no. 1. (January 1991.): 118-23.

Natarajan, V; Taher, M, M; Roehm, B; Parinandi, N, L; Schmid, H, H; Kiss, Z; Garcia, J G. "Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.." The Journal of biological chemistry. Vol. 268, no. 2. (January 1993.): 930-7.

Parinandi, N, L; Scribner, W, M; Vepa, S; Shi, S; Natarajan, V. "Phospholipase D activation in endothelial cells is redox sensitive.." Antioxidants & redox signaling. Vol. 1, no. 2. (January 1999.): 193-210.

Vepa, S; Scribner, W, M; Parinandi, N, L; English, D; Garcia, J, G; Natarajan, V. "Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells.." The American journal of physiology. Vol. 277, no. 1 Pt 1. (January 1999.): L150-8.

Shi, S; Garcia, J, G; Roy, S; Parinandi, N, L; Natarajan, V. "Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction.." American journal of physiology. Lung cellular and molecular physiology. Vol. 279, no. 3. (January 2000.): L441-51.

Natarajan, V; Scribner, W, M; Morris, A, J; Roy, S; Vepa, S; Yang, J; Wadgaonkar, R; Reddy, S, P; Garcia, J, G; Parinandi, N L. "Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells.." American journal of physiology. Lung cellular and molecular physiology. Vol. 281, no. 2. (January 2001.): L435-49.

Parinandi, N, L; Roy, S; Shi, S; Cummings, R, J; Morris, A, J; Garcia, J, G; Natarajan, V. "Role of Src kinase in diperoxovanadate-mediated activation of phospholipase D in endothelial cells.." Archives of biochemistry and biophysics. Vol. 396, no. 2. (January 2001.): 231-43.

Cummings, Rhett; Parinandi, Narasimham; Wang, Lixin; Usatyuk, Peter; Natarajan, Viswanathan. "Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung.." Molecular and cellular biochemistry. Vol. 234-235, no. 1-2. (January 2002.): -.

Cummings, Rhett, J; Parinandi, Narasimham, L; Zaiman, Ari; Wang, Lixin; Usatyuk, Peter, V; Garcia, Joe G, N; Natarajan, Viswanathan. "Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells.." The Journal of biological chemistry. Vol. 277, no. 33. (January 2002.): 30227-35.

Parinandi, Narasimham, L; Kleinberg, Michael, A; Usatyuk, Peter, V; Cummings, Rhett, J; Pennathur, Arjun; Cardounel, Arturo, J; Zweier, Jay, L; Garcia, Joe G, N; Natarajan, Viswanathan. "Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells.." American journal of physiology. Lung cellular and molecular physiology. Vol. 284, no. 1. (January 2003.): L26-38.

Pandian, Ramasamy, P; Parinandi, Narasimham, L; Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan. "Novel particulate spin probe for targeted determination of oxygen in cells and tissues.." Free radical biology & medicine. Vol. 35, no. 9. (January 2003.): 1138-48.

Pandian, Ramasamy, P; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Measurement of oxygen consumption in mouse aortic endothelial cells using a microparticulate oximetry probe.." Archives of biochemistry and biophysics. Vol. 420, no. 1. (January 2003.): 169-75.

Byrnes, Colman, K; Bahadursingh, Anil; Akhter, Nabeel; Parinandi, Narasimham, L; Natarajan, Viswanathan; Montgomery, Elizabeth; Tihan, Tarik; Duncan, Mark, D; Nass, Petra, H; Harmon, John W. "Duodenal reflux produces hyperproliferative epithelial esophagitis--a possible precursor to esophageal adenocarcinoma in the rat.." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. Vol. 7, no. 2. (January 2003.): 172-80.

Rizzi, Cecile; Samouilov, Alexandre; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Application of a trityl-based radical probe for measuring superoxide.." Free radical biology & medicine. Vol. 35, no. 12. (January 2003.): 1608-18.

Roy, Shukla; Parinandi, Narasimham; Zeigelstein, Roy; Hu, Qinghua; Pei, Yong; Travers, Jeffrey, B; Natarajan, Viswanathan. "Hyperoxia alters phorbol ester-induced phospholipase D activation in bovine lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 5, no. 2. (January 2003.): 217-28.

Usatyuk, Peter, V; Vepa, Suryanarayana; Watkins, Tonya; He, Donghong; Parinandi, Narasimham, L; Natarajan, Viswanathan. "Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 5, no. 6. (January 2003.): 723-30.

Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan. "Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry.." Archives of biochemistry and biophysics. Vol. 424, no. 1. (January 2004.): 81-8.

Kutala, Vijay Kumar; Parinandi, Narasimham, L; Pandian, Ramasamy, P; Kuppusamy, Periannan. "Simultaneous measurement of oxygenation in intracellular and extracellular compartments of lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 6, no. 3. (January 2004.): 597-603.

Pandian, Ramasamy, P; Kutala, Vijay Kumar; Liaugminas, Alex; Parinandi, Narasimham, L; Kuppusamy, Periannan. "Lipopolysaccharide-induced alterations in oxygen consumption and radical generation in endothelial cells.." Molecular and cellular biochemistry. Vol. 278, no. 1-2. (January 2005.): 119-27.

Khanna, Savita; Roy, Sashwati; Slivka, Andrew; Craft, Tara K, S; Chaki, Soma; Rink, Cameron; Notestine, Margaret, A; DeVries, A Courtney; Parinandi, Narasimham, L; Sen, Chandan K. "Neuroprotective properties of the natural vitamin E alpha-tocotrienol.." Stroke; a journal of cerebral circulation. Vol. 36, no. 10. (January 2005.): 2258-64.

Zhou, Yingbi; Varadharaj, Saradhadevi; Zhao, Xue; Parinandi, Narasimham; Flavahan, Nicholas, A; Zweier, Jay L. "Acetylcholine causes endothelium-dependent contraction of mouse arteries.." American journal of physiology. Heart and circulatory physiology. Vol. 289, no. 3. (January 2005.): H1027-32.

Martin, Sergio, F; Chatterjee, Subroto; Parinandi, Narasimham; Alevriadou, B Rita. "Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells.." Vascular pharmacology. Vol. 43, no. 3. (January 2005.): 148-56.

Saradhadevi, Varadharaj; Sakthivel, Ramasamy; Vedamoorthy, Srikanth; Selvam, Ramasamy; Parinandi, Narasimham. "Alterations in band 3 protein and anion exchange in red blood cells of renal failure patients.." Molecular and cellular biochemistry. Vol. 273, no. 1-2. (January 2005.): 11-24.

Parinandi NL, Deli E, Raj RK, ramasarma T, Holman RT, Bibus D. "High co3 nutritive status indicated by essential fatty acid projiles in Keralites of India." Lipids - Submitted. (January 2005.): -.

Varadharaj, Saradhadevi; Watkins, Tonya; Cardounel, Arturo, J; Garcia, Joe G, N; Zweier, Jay, L; Kuppusamy, Periannan; Natarajan, Viswanathan; Parinandi, Narasimham L. "Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells.." Antioxidants & redox signaling. Vol. 7, no. 1-2. (January 2005.): 287-300.

Martin SF; Chatterjee S; Parinandi N; Alevriadou BR. "Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells.." Vascular Pharmacology. Vol. 43, no. 3. (September 2005.): 148-.

Varadharaj S, Watkins T, Cardounel AJ, Joe GN Garcia, Zweier JL, Kuppusamy P, Natarajan V, Parinandi NL. "Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells." Antioxidants Redox Signal. Vol. 7(1-2), (January 2005.): 287-300.

Khanna S, roy s, Slivka A, Craft TKS, Chaki S, Rink C. "Molecular basis of vitamin E action. Potent neuroprotective properties of a-tocotrienol in cultured neurons and against stroke." Stroke. Vol. 36(10), (January 2005.): 2258-64.

Chowdhury, Ashis, K; Watkins, Tonya; Parinandi, Narasimham, L; Saatian, Bahman; Kleinberg, Michael, E; Usatyuk, Peter, V; Natarajan, Viswanathan. "Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells.." The Journal of biological chemistry. Vol. 280, no. 21. (January 2005.): 20700-11.

Zhou Y; Varadharaj S; Zhao X; Parinandi N; Flavahan NA; Zweier JL. "Acetylcholine causes endothelium-dependent contraction of mouse arteries.." American Journal Of Physiology. Heart And Circulatory Physiology. Vol. 289, no. 3. (September 2005.): H1027-.

Varadharaj, Saradhadevi; Steinhour, Emily; Hunter, Melissa, G; Watkins, Tonya; Baran, Christopher, P; Magalang, Ulysses; Kuppusamy, Periannan; Zweier, Jay, L; Marsh, Clay, B; Natarajan, Viswanathan; Parinandi, Narasimham L. "Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases.." Cellular signalling. Vol. 18, no. 9. (January 2006.): -.

Parinandi, Narasimham, L; Sen, Chandan, K; Kuppusamy, Periannan. "Joint International Conference on EPR Spectroscopy and wound healing.." Antioxidants & redox signaling. Vol. 8, no. 7-8. (January 2006.): 1385-7.

Khanna, Savita; Roy, Sashwati; Parinandi, Narasimham, L; Maurer, Mariah; Sen, Chandan K. "Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol.." Journal of neurochemistry. Vol. 98, no. 5. (January 2006.): 1474-86.

Khan, Mahmood; Varadharaj, Saradhadevi; Shobha, Jagdish, C; Naidu, Madireddi, U; Parinandi, Narasimham, L; Kutala, Vijay Kumar; Kuppusamy, Periannan. "C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes.." Journal of cardiovascular pharmacology. Vol. 47, no. 1. (January 2006.): 9-20.

Khan, Mahmood; Varadharaj, Saradhadevi; Ganesan, Latha, P; Shobha, Jagdish, C; Naidu, Madireddi, U; Parinandi, Narasimham, L; Tridandapani, Susheela; Kutala, Vijay Kumar; Kuppusamy, Periannan. "C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling.." American journal of physiology. Heart and circulatory physiology. Vol. 290, no. 5. (January 2006.): H2136-45.

Zhou, Yingbi; Mitra, Srabani; Varadharaj, Saradhadevi; Parinandi, Narasimham; Zweier, Jay, L; Flavahan, Nicholas A. "Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.." Circulation research. Vol. 98, no. 11. (January 2006.): 1439-45.

Bratasz, Anna; Weir, Nathan, M; Parinandi, Narasimham, L; Zweier, Jay, L; Sridhar, Rajagopalan; Ignarro, Louis, J; Kuppusamy, Periannan. "Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 10. (January 2006.): 3914-9.

Mazerik JN, Mikkilineni H, Kuppusamy VA, Steinhour E, Peltz A, Marsh CB, Kuppusamy P, Parinandi NL. "Mercury activates phospholipase A2 and induces formation of arachidonic acid metabolites in vascular endothelial cells - IN REVIEW." Toxicol. Mech. Methods. (January 2006.): -.

Zhou Y; Mitra S; Varadharaj S; Parinandi N; Zweier JL; Flavahan NA. "Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.." Circulation Research. Vol. 98, no. 11. (June 2006.): 1439-.

Usatyuk, Peter, V; Parinandi, Narasimham, L; Natarajan, Viswanathan. "Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.." The Journal of biological chemistry. Vol. 281, no. 46. (January 2006.): 35554-66.

Magalang, Ulysses, J; Rajappan, Ramya; Hunter, Melissa, G; Kutala, Vijay, K; Kuppusamy, Periannan; Wewers, Mark, D; Marsh, Clay, B; Parinandi, Narasimham L. "Adiponectin inhibits superoxide generation by human neutrophils.." Antioxidants & redox signaling. Vol. 8, no. 11-12. (January 2006.): 2179-86.

Mazerik, Jessica, N; Hagele, Thomas; Sherwani, Shariq; Ciapala, Valorie; Butler, Susan; Kuppusamy, M Lakshmi; Hunter, Melissa; Kuppusamy, Periannan; Marsh, Clay, B; Parinandi, Narasimham L. "Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.." International journal of toxicology. Vol. 26, no. 6. (January 2007.): -.

Kulkarni AC; Kuppusamy P; Parinandi N. "Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy.." Antioxidants & Redox Signaling. Vol. 9, no. 10. (October 2007.): 1717-.

Hagele, Thomas, J; Mazerik, Jessica, N; Gregory, Anita; Kaufman, Bruce; Magalang, Ulysses; Kuppusamy, M Lakshmi; Marsh, Clay, B; Kuppusamy, Periannan; Parinandi, Narasimham L. "Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress.." International journal of toxicology. Vol. 26, no. 1. (January 2007.): -.

Parinandi, Narasimham, L; Sharma, Ashish; Eubank, Timothy, D; Kaufman, Bruce, F; Kutala, Vijay Kumar; Marsh, Clay, B; Ignarro, Louis, J; Kuppusamy, Periannan. "Nitroaspirin (NCX-4016), an NO donor, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells.." Antioxidants & redox signaling. Vol. 9, no. 11. (January 2007.): -.

Parinandi NL, Sharma A, Eubank TD, Kaufman BF, Kutala VK, Marsh CB, Ignarro LJ, Kuppusamy P. "Nitroaspirin, NCX-4016, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothilial cells." Free Radic. Biol. Med. - IN REVIEW. (January 2007.): -.

Kulkarni, Aditi, C; Kuppusamy, Periannan; Parinandi, Narasimham. "Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy.." Antioxidants & redox signaling. Vol. 9, no. 10. (January 2007.): -.

Kulkarni, A.; Kuppusamy, P.; Parinandi, N. L.. Antioxid Redox Signal. Vol. 9, no. 10. (January 2007.): 1717-1730.

Kulkarni A, Kuppusamy P, Parinandi, NL. "The lead actor in the pathophysiological drama: Enactment of the trinity of normoxia, hypoxia and hyperoxia in disease and therapy." Antioxid Redox Signal. (January 2007.): -.

Pope, Arthur, J; Druhan, Lawrence; Guzman, Jorge, E; Forbes, Scott, P; Murugesan, Velayutham; Lu, Deqin; Xia, Yong; Chicoine, Louis, G; Parinandi, Narasimham, L; Cardounel, Arturo J. "Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.." American journal of physiology. Cell physiology. Vol. 293, no. 5. (January 2007.): -.

Hagele TJ, Mazerik JN, Gregory A, Kaufman BF, Magalang U, Kuppusamy M, Marsh CB, Kuppusamy P, Parinandi NL. "Mercury activates vascular endothelia cell phospholipase D through thiols and oxidative stress." Radic. Biol. Med.. (January 2007.): -.

Usatyuk, Peter, V; Romer, Lewis, H; He, Donghong; Parinandi, Narasimham, L; Kleinberg, Michael, E; Zhan, Steve; Jacobson, Jeffrey, R; Dudek, Steven, M; Pendyala, Srikanth; Garcia, Joe G, N; Natarajan, Viswanathan. "Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin.." The Journal of biological chemistry. Vol. 282, no. 32. (January 2007.): -.

Usatyuk PV, Romer L, He D, Prinandi NL, Kleinberg ME, Zhan S, Jacobson JR, Dudek S, Garcia JGN, Natarajan V. "Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin." Biol. Chem. - IN REVIEW. (January 2007.): -.

Magalang UJ, Cruff JP, Rajappan R, Hunter MG, Patel T, Marsh CB, Raman SV, Parinandi NL. "Intermittent Hypoxia Suppresses Adiponectin Secretion by Adipocytes." Exp Clin Endocrinol Diabetes.. (June 2008.): -.

Kutala VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. "Spirulina - A Blue-green Alga with Novel Therapeutic Actions." Recent Progress in Medicinal Plants. Vol. 22, (January 2008.): -.

Steinhour E, Sherwani SI, Mazerik JN, Ciapala V, O'Connor Butler E, Cruff JP, Magalang U, Parthasarathy S, Sen CK, Marsh CB, Kuppusamy P, Parinandi NL. "Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase." Mol Cell Biochem.. Vol. 315, no. 1-2. (January 2008.): 97-112.

Forbes SP, Druhan LJ, Guzman JE, Parinandi NL, Zhang L, Green-Church KB, Cardounel AJ.. "Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in NO regulation.." Biochemistry. Vol. 47, no. 6. (January 2008.): 1819-1826.

Forbes SP; Druhan LJ; Guzman JE; Parinandi N; Zhang L; Green-Church KB; Cardounel AJ. "Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation.." Biochemistry. Vol. 47, no. 6. (February 2008.): 1819-.

Kutala VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. "Drug-induced nephrotoxicity protection by Spirulina.." Spirulina in Human Nutrition. (January 2008.): 153-176.

Oliver SR; Wright VP; Parinandi N; Clanton TL. "Thermal tolerance of contractile function in oxidative skeletal muscle: no protection by antioxidants and reduced tolerance with eicosanoid enzyme inhibition.." American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology. Vol. 295, no. 5. (November 2008.): R1695-.

Oliver SR, Wright VP, Parinandi N, Clanton TL. "Thermal tolerance of contractile function in oxidative skeletal muscle: no protection by antioxidants and reduced tolerance with eicosanoid enzyme inhibition." Am J Physiol Regul Integr Comp Physiol.. Vol. 295, no. 5. (November 2008.): R1695-705.

Khan M, Iyyapu KM, Kutala V, Kotha S, Parinandi NL, Hamlin RL, Kuppusamy P. "Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS leading to enhancement of nitric-oxide bioavailability and tissue oxygenation." Antioxid Redox Signal.. (October 2008.): -.

Magalang UJ; Cruff JP; Rajappan R; Hunter MG; Patel T; Marsh CB; Raman SV; Parinandi NL. "Intermittent hypoxia suppresses adiponectin secretion by adipocytes.." Experimental And Clinical Endocrinology & Diabetes: Official Journal, German Society Of Endocrinology [And] German Diabetes Association. Vol. 117, no. 3. (March 2009.): 129-.

Sathishkumar K; Gao X; Raghavamenon AC; Parinandi N; Pryor WA; Uppu RM. "Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways.." Free Radical Biology & Medicine. Vol. 47, no. 5. (September 2009.): 548-.

Magalang UJ; Richards K; McCarthy B; Fathala A; Khan M; Parinandi N; Raman SV. "Continuous positive airway pressure therapy reduces right ventricular volume in patients with obstructive sleep apnea: a cardiovascular magnetic resonance study.." Journal Of Clinical Sleep Medicine: JCSM: Official Publication Of The American Academy Of Sleep Medicine. Vol. 5, no. 2. (April 2009.): 110-.

Sliman SM; Eubank TD; Kotha SR; Kuppusamy ML; Sherwani SI; Butler ES; Kuppusamy P; Roy S; Marsh CB; Stern DM; Parinandi NL. "Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection.." Molecular And Cellular Biochemistry. Vol. 333, no. 1-2. (January 2010.): 9-.

Khanna S; Parinandi NL; Kotha SR; Roy S; Rink C; Bibus D; Sen CK. "Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection.." Journal Of Neurochemistry. Vol. 112, no. 5. (March 2010.): 1249-.

O'Connor Butler ES; Mazerik JN; Cruff JP; Sherwani SI; Weis BK; Marsh CB; Raghavamenon AC; Uppu RM; Schmid HH; Parinandi NL. "Lipoxygenase-catalyzed phospholipid peroxidation: preparation, purification, and characterization of phosphatidylinositol peroxides.." Methods In Molecular Biology (Clifton, N.J.). Vol. 610, (January 2010.): 387-.

Sathishkumar K; Raghavamenon AC; Ganeshkumar K; Telaprolu R; Parinandi NL; Uppu RM. "Simultaneous analysis of expression of multiple redox-sensitive and apoptotic genes in hypothalamic neurons exposed to cholesterol secoaldehyde.." Methods In Molecular Biology (Clifton, N.J.). Vol. 610, (January 2010.): 263-.

Kline MA; O'Connor Butler ES; Hinzey A; Sliman S; Kotha SR; Marsh CB; Uppu RM; Parinandi NL. "A simple method for effective and safe removal of membrane cholesterol from lipid rafts in vascular endothelial cells: implications in oxidant-mediated lipid signaling.." Methods In Molecular Biology (Clifton, N.J.). Vol. 610, (January 2010.): 201-.

 

Presentations

"Catecholamines as Model Systems to Study Metal-induced Free Radical Oxidations." Presented at Analytical Chemistry & Industrial Processing Workshop Symposium, . (July 1985)

"Antioxidants for Vanadium-induced Lipid Peroxidation in the Rat Brain in vitro." Presented at Sigma XI Annual Graduate Symposium, . (March 1985)

"Trace Metal-induced Lipid Peroxidation in Rat Brain and Mechanisms." Presented at The Hormel Institute, University of Minnesota, . (February 1986)

"Vanadium-induced Lipid Peroxidation in the Rat Brain." Presented at The Ohio Academy of Sciences Annual Conference, . (June 1986)

"Lipid Peroxidation - Fact or Fiction." Presented at University of Minnesota, Hormel Institute Seminar Series, . (July 1987)

"Free Radicals - Biology, Biochemistry and Toxicity." Presented at Andhra University, Department of Environmental Sciences Educational Lectures, . (June 1988)

"Biochemican and Molecular basis of Circadian Rhythms." Presented at Hormel Institute Seminar Series, University of Minnesota, . (June 1988)

"Diabetic Heart and Kidney exhibit Increased Resistance to Oxidative Stress." Presented at American Diabetes Association, Minneapolis Chapter, . (August 1989)

"Lipid Peroxidation in Sciatic Nerve during Ischemia and Reperfusion." Presented at The Mayo Clinic, Peripheral Neuropathy Division, . (July 1989)

"Mechanisms of Vanadium-induced Free Radical-mediated Lipid Peroxidation in Rat Brain." Presented at Annual Conference on Trace Substances in Environmental Health, . (July 1990)

"Oxidative Stress and Lipid Peroxidation in Myocardium." Presented at IUPUC Medical Center, Division of Pulmonary and Critical Care Medicine, . (June 1990)

"Involvement of Src Kinase in Oxidant-mediated Activation of Phospholipase D in Vascular Endothelial Cells." Presented at Johns Hopkins University, Combined Research Seminar Series, . (February 1999)

"Signal Transduction and Kinases." Presented at Chemical Abstracts Service, American Chemical Society, . (July 2000)

"NAD[P]H Oxidase-mediated Generation of Reactive Oxygen Species during Hyperoxia in Vascular Endothelial Cells." Presented at Johns Hopkins University, School of Public Health, . (October 2001)

"Particulate Matter Respiratory Toxicity - Present State." Presented at Johns Hopkins University, Lung Seminar Series, . (February 2001)

"Role of Phospholipase D in Urban Particulate Matter-induced Interleukin-8 Secretion by Bronchial Epithelial Cells." Presented at Maryland Thoracic Society, . (March 2001)

"Phospholipase and Protein Kinase Network in Pulmonary Endothelial Cell Oxidant Signaling." Presented at OSU Division of Pulmonary and Critical Care Pulmonary Research Conference, . (August 2002)

"Oxidant Activation of Phospholipase D in Vascular Endothelium and Respiratory Tract Epithelium." Presented at OSU College of Pharmacy, . (June 2002)

"Electron Paramagnetic Resonance Spectroscopic Analysis of Lipid Peroxidation." Presented at American Oil Chemists' Society Annual Meeting, . (May 2003)

"Signaling mechanisms of agricultural dust-induced inflammatory cytokine release by respiratory tract epithelial cells." Presented at University of Nebraska, Division of Pulmonary & Critical Care Medicine, . (November 2004)

"Redox-active antioxidant-mediated Lipid Signaling." Presented at Medical College of Virgina, Department of Cardiology, . (April 2006)

"Lipidomics of phospholipase cross-talk in vascular endothelium." Presented at OSU College of Ecology, Department of Nutrition, . (November 2006)

"Agricultural Particulate matter-induced inflammatory cytokine secretion regulation by A2 in lung epithelial cells." Presented at Society of Free Radical Biology and Medicine Annual Conference, . (November 2006)

"Nitric oxide-mediated lipid signaling in the vascular endothelium and the barrier dysfunction." Presented at University of Toledo, Department of Biological Sciences, . (April 2007)

"Phospholipase D, a Redox-Sensitive Lipid Signalase in Lung Endothelial Cells, Regulates Vascular Permeability and Vasculotoxicity.." Presented at Harvard Medical School, Brigham and Women's Hospital, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, . (July 2009)

"Metals, Oxidative Stress, Antioxidants and Vascular Endothelium." Presented at CTI Science, Inc., Lexington, KY. (October 2009)

"Lipid Oxygenases Regulate Phospholipase D activation Under Redox Modulation in Endothelial Cells." Dayton, OH. (October 2009)

"Mercury-induced Vasculotoxicity and Impairment of Angiogenesis." Presented at Silver Jubilee Celebrations of The International Academy of Oral Medicine & Toxicology (IAOMT, USA), Las Vegas, NV. (September 2009)

"Mercury-induced Lipid Signaling - A membrane Basis for Mercury Toxicity." Presented at International Academy of Oral Medicine & Toxicology, London, UK. (February 2010)

"How to Evolve as a Successful Scientist." Presented at Society for Free Radical Research, Annual Conference, Hyderabad, IN|IND. (January 2010)

"Adipose Tissue Protects Against Hyperoxic Lung Damage." Presented at Society for Free Radical Research, Annual Conference, Hyderabad, IN|IND. (January 2010)

"Novel Sulfhydryl Protective Compound for Leaky Gut Syndrome." Presented at Autism One/Generation Rescue, Annual Conference, Chicago, IL. (May 2010)

 

Professional Activities

2006 Ohio State University Pulmonary Division Grant Review.
2006 AHA Grant-in-Aid Review.