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Naeem Ali, MD


Staff photo

Medical Staff Administration
410 W 10th Ave
Columbus, OH 43210

Phone: (614) 293-8158

Email: ali.24@osu.edu

 

Current OSU Appointments

Associate Professor-Clinical, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

 

Clinical Interest

Critical Care

Sepsis-induced acute lung injury and ventilator management

Intensive care unit acquired weakness, critical illness polyneuromyopathy

ICU organization and process improvement

Glucose management

Continuing Education, Extension, and Other Courses Taught

Within the first several years in academic critical care, I recognized the importance of the multidisciplinary focus to clinical care. This clinical focus was in stark contrast to the general structure of clinical education. I was struck through active participation in continuing education conferences in Respiratory Therapy, Nursing and Medical Societies, that each of these disciplines only attempted to educate “their own”. This was likely due to a historical approach and the increasingly specific accreditation demands. In 2003, I gave my first lecture at the American Society of Health System Pharmacists in New Orleans, LA on the impact of computerized ordering systems on ICU care. Then in 2006, I gave a lecture at a statewide Respiratory Therapy conference (CCRC). The experience of these presentations gave me the insight of “spreading the message” of the principals that guide care in the ICU to non-MD professionals could have a great impact on the ability to deliver evidence-based practices to our patients in the critical care unit. I recognized there was an opportunity to start a regional conference that sought to educate the entire team of healthcare professionals on the important principles of patient care that needed widely disseminated. This resulted in my leading the development of the MATCH Conference (https://ccme.osu.edu/ConferenceDetail.aspx?ID=667) The MATCH Conference is dedicated to the mission of providing “state-of-the-art education in a multidiscipline format (team presentations) in a multidiscipline environment. RTs, RN and MDs can all receive continuing education credit. This educational environment is unique within critical care and is consistent with the national goals for the delivery of ICU patient care. In its first year, more than 230 persons from six different areas of healthcare attended. We plan to continue this conference annually with a goal of >350 attendees in 2010. From these goals, I have learned that my interests in this area is extending the reach of medical education to all of the disciplines that we collaborate with and rely upon to execute our plan of care. My plan is to expand on this avenue of multidisciplinary education as a primary focus in future years.

Creative Works

Developing a clinical laboratory: a clinical database to better understand care in the ICU

With the advent of electronic information systems nationally and at OSU, there was significant hope that clinical data would become more readily available and thus better inform process improvement initiatives. However, soon after joining the faculty at OSU, it became apparent that these systems' underlying databases were not designed to support ready extraction of data for these purposes. They primarily served the needs of accurately maintaining a patient's medical record in perpetuity and support hospital financial reimbursement. As such, as I became involved in understanding ICU process of care, I became aware of the need to expedite the information transfer from these systems to improve care in our units.

To fill a gap in our current resources, a small group of individuals met to discuss ongoing data collection needs to better understand ICU process of care. I led the portion of this group generated the needs for general measures of ICU care. This included generating an accurate list of ICU patients, their need for mechanical ventilation, the specific ventilator practices used and their receipt of daily quality practices like, sedation stops, ventilator liberation trials and other components of the ventilator bundle.

After this list of variables was developed, I spent 6-8 months defining clinical documentation fields within the electronic medical record that represented these practices. Working with programmers within the Information Warehouse, we collaboratively designed the data and database workflows to populate the ICU Minimum Dataset. For the smaller list of variables not readily available electronically, I participated with our clinical trials office in the training of data collectors who acquired these important variables to complement and verify the automatic query results. I continue to supervise these data collectors to ensure the ongoing integrity of the database.

As a result of this work, we are able to better understand the impact of our various ICU initiatives. Since 2004, we can demonstrate that our ventilator practices are objectively better, severity adjusted mortality for sepsis patients are improved and our compliance with quality practices have improved. Additionally, more recent hospital initiatives involving antibiotic ordering has resulted in an improved ability to rapidly administer antibiotics to our patients with sepsis. This database has dramatically changed our understanding of ICU process and practices. It has allowed us to better plan and initiate process improvement initiatives.

A separate group, led by Jim O'Brien developed a similar database for sepsis patients within our ICU (termed the Sepsis Minimum Dataset). I collaborated with Dr O'Brien in its development and have had ongoing responsibility to maintain the database and ensure accuracy of the human and electronic processes that continue to populate the patient lists and data for the Db.



CLINICAL PROCESS IMPROVEMENT INITIATIVES (SELECT LISTING)



2003, Insulin infusion Guidelines, Medical ICU, Chair Dara Schuster and Brenda Hixon-Vermillion; Role on project, Participant

On this committee we revised the insulin infusion guideline for DKA and catered it for the NPO, Medical ICU population. Clinical process effected: Hyperglycemia



2005, Ventilator Process Improvement MICU, Self-breathing trials implementation, Chair: Stephen Hoffmann; Role on project, Participant

Published data suggested a need to remove Weaning Parameters from the extubation process in order to improve the time from respiratory recovery to SBT. Clinical Process effected: time to SBT



2007, Sepsis care in the ED, Chair, Naeem Ali, Jeff Caterino; Role on Project: Chair

UHC sponsored PI initiative on delivering bundle care measures to Sepsis patients. Clinical Process measure effected: time to IVFs



2009, Ventilator Bundle Implementation, Chair: Naeem Ali; Role on project, Chair

MICU initiative designed to standardize the ordering process for Ventilator Bundle orders and improve compliance. Clinical Process effected: SBT compliance and Sedative interruption rates in the MICU



2010, Ventilator Bundle Implementation, Chair: Naeem Ali; Role on project, Chair

HS wide initiative designed to standardize the ordering process for Ventilator Bundle orders and improve compliance. Clinical Process effected: SBT compliance and Sedative interruption rates across the HS



2011, Implementation of the MEWS in PCUs, Chair: Naeem Ali and Jerry Mansfield; Role on the Project: Chair

Pilot project designed to determine if MEWS was feasible in the hands of bedside nursing to aid in clinical decision making. Performed across the HealthSystem simultaneously and designed to inform full IHIS implementation. Clinical Process effected, Vital signs monitoring



2012-3, Implementation of the MEWS across the inpatient care environment, Chair: Naeem Ali and Jerry Mansfield; Role on the Project: Chair

Implementation project designed to make MEWS scores available to bedside clinicians. Activities included overseeing the development of a calculation of MEWS from available clinical data, validation in IHIS, process evaluation, ERT oversight. Clinical Process effected: Acute illness detection.



2013-present, Ventilator Bundle Implementation, Chair: Naeem Ali; Role on project, Chair

HS wide initiative designed to confirm compliance with the ventilator bundle and improve oral care compliance. In addition, this initiative is designed to reduce the use of continuous sedative infusions. Clinical Process effected: Delirium and ventilator days

Published Works

The topics covered in a global overview of my work spans a direct line from my initial interests in the mechanisms of acute lung injury to my current interest in non-pulmonary organ failure in patients with sepsis. As an early fellow in critical care medicine, I was struck with the unique requirements of the ICU environment. As we were transitioning our ordering system from paper to a computer interface, I took the opportunity to propose, execute and publish my observations of the critical elements that led to successful implementation of these systems in the ICU. After these investigation performed, I left this area to enter into the laboratory to understand the basic mechanisms of acute lung injury (ALI), the most common cause of respiratory failure in the medical ICU. This research focused on TGF-beta regulation and while it took a while for this line of work to mature, it formed the nidus of research that led to my current funding for acute lung injury in severe sepsis. (K23 RR019544) As this research matured, I continued to pursue the clinical problems that influenced the development of ALI in ICU patients. The problem of glucose dysregulation was becoming more widely recognized. Significant research pointed to the fact that glucose dysregulation could lead to increased cellular stress and perhaps a greater propensity for ALI. As a result, I designed a pilot study to determine the role of hyperglycemia in patients at high-risk for severe sepsis. This retrospective analysis led to the publication of a report outlining the risk hyperglycemia appears to pose to patients with acute myeloid leukemia. This disease cohort was selected because of their propensity to develop severe sepsis and ALI (OR 30+ compared to non-leukemia). This report was published in 2007 and led to the main clinical study supported by my K23 research award. This study is now closed to enrollment and we are analyzing data. In the most recent phase of my research career, my interest was piqued by the connection between glucose dysregulation and the problem of critical illness polyneuropathy (also termed ICU-acquired weakness). This recently described clinical entity was known to occur more frequently than once suspected and to be associated with significant clinical morbidity. As a result, in 2005 we initiated a study across five academic medical centers that advanced our understanding of the impact of this disorder and was published in 2008. This nexus of weakness and glucose dysregulation now dominates my research program. This opened up opportunities to do multi-institutional interdisciplinary research. [eProtocol-Insulin LDS Hospital UT, voluntary extension of NIH Roadmap Contract “Reengineering Clinical Research in Critical Care.” (NO1-HC 45210, HHSN 268200425210C)] Additionally, I have been recently appointed the Chair of an International Consensus Conference to delineate definitions and standard assessments for this disorder of ICU-acquired weakness. This conferences work is progressing nicely and will be completed in the Fall of 2011.

Academic Advising

2011 - present Scott Meehan, The Ohio State University.
2011 - present Brian Mieczkowski, The Ohio State University.
2008 - 2009 Leanne Strack The Ohio State University. Clinical Determinants of Handgrip Strength in Critically ill patients.
2008 - 2010 Eric Adkins The Ohio State University. Predictors of response to hypothermia in in-hospital cardiac arrest
2009 - 2010 Shiva Rahmanian The Ohio State University. Graduated 2010.
2009 - 2010 Brent Riscili The Ohio State University. Graduated 2010. Pandemic disaster planning in an academic medical center
2009 - 2010 Jason Huet The Ohio State University. Graduated 2010. ICU readmission risk prediction
 

Certifications

1997 - present Medical License: State Medical Board of Ohio
1999 - present Internal Medicine: American Board of Internal Medicine
2000 - present Advance Cardiac Life Support: The Ohio State University
2000 - present Basic Life Support: The Ohio State University
2002 - present Pulmonary Disease: American Board of Internal Medicine
2003 - present Sleep Medicine - Part I: American Board of Sleep Medicine
2003 - present Critical Care Medicine: American Board of Internal Medicine
2004 - present Sleep Medicine - Part II: American Board of Sleep Medicine
 

Chapters in Books

Rami Khayat, Naeem Ali, Ulysses Magalang. "Monitoring Respiration in Sleep." In Principles of Sleep Medicine. -. January 2007.

Steven Kadiev, Naeem Ali. "Sleep in the Intensive Care Unit." In Sleep Medicine Clinics. Vol. 3 (4). Edited by Ulysses Magalang. -. Burlington, MA, US|USA: Elsevier, January 2008.

Naeem Ali, James Krinsley, Jean-Charles Preiser. "Glucose variability in critically ill patients." In Yearbook of Intensive Care and Emergency Medicine, 2009. Edited by Jean-Louis Vincent. TBD-. New York, NY, US|USA: Springer, January 2008.

Naeem Ali. "Introduction to the Post-Intensive Care Syndrome." In Legacy of Critical Care. Edited by Stevens, R, Hart, N, Herridge, M. -.

 

Clinical Services

07/01/2003 Staff Physician in the medical ICU (OSUHS, Internal Medicine)
09/01/2003 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
12/01/2003 Staff Physician, Pulmonary Consultative Service (Ohio State University Hospitals, Main Campus, Internal Medicine)
01/01/2004 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
04/01/2004 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
06/01/2004 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
08/01/2004 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
11/01/2004 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
01/01/2005 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
01/01/2005 Staff Physician, Critical Care and Pulmonary consultative service (Ohio State University Hospital East, Internal Medicine)
03/01/2005 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
07/01/2005 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
08/01/2005 Staff Physician (Consultative Service)
10/01/2005 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
11/01/2005 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
02/01/2006 Staff Physician, Pulmonary and Critical Care consultation service (Ohio State University Hospital East, Internal Medicine)
07/01/2006 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
08/01/2005 - 08/01/2006 Staff Physician, Pulmonary Consultation Service (The Ohio State University Hospital, Main Campus, Internal Medicine)
08/01/2006 Staff Physician, OSU East Pulmonary and Critical Care consultation service (Ohio State University Hospital East, Internal Medicine)
01/01/2007 Staff Physician, 8ICU (8th floor Rhodes Hall, University Hospitals, Main Campus, Internal Medicine)
03/01/2007 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
04/01/2007 Staff Physician, 8ICU (8th floor Rhodes Hall, University Hospitals, Main Campus, Internal Medicine)
08/01/2007 Staff Physician, 8ICU (8th floor Rhodes Hall, University Hospitals, Main Campus, Internal Medicine)
10/01/2007 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
12/01/2007 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
04/01/2008 Staff Physician, 8ICU (8th floor Rhodes Hall, University Hospitals, Main Campus, Internal Medicine)
10/01/2008 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
03/01/2009 Staff Physician, 8ICU (8th floor Rhodes Hall, University Hospitals, Main Campus, Internal Medicine)
04/01/2009 Staff Physician, MICU (11th floor Rhodes Hall, University Hospital, Main Campus, Internal Medicine)
06/01/2009 Staff Physician, 8ICU (8th floor Rhodes Hall, University Hospitals, Main Campus, Internal Medicine)
07/01/2009 Staff physician on the 8ICU (8th Floor Rhodes ICU OSU Hospital Main campus, Internal Medicine)
08/01/2009 Staff physician, MICU (11th floor Rhodes Hall, University Hospital Main Campus, Internal Medicine)
09/01/2009 Staff physician, 8ICU (8th floor Rhodes Hall, University Hospitals, Main Campus, Internal Medicine)
12/01/2009 Staff Physician, MICU (11th floor MICU, Rhodes Hall, Universoty Hospital Main campus, Internal Medicine)
01/01/2010 Staff Physician (8ICU, Medicine)
04/01/2010 Staff Physician (MICU)
11/01/2010 Staff Physician (MICU)
12/01/2010 Staff Physician (8ICU)
01/01/2011 Staff Physician (MICU)
04/01/2011 Staff Physician (MICU 40)
07/01/2011 Staff Phyician (MICU 90)
08/01/2011 Staff Physician (8ICU)
10/01/2011 Staff Physician (Risk)
11/01/2011 Staff Physician (8ICU)
04/01/2012 Staff Physician (8ICU)
06/01/2012 Staff Physician (MICU 40)

Conferences

Morales,J,E; Ali,N; Bhatt,N; Hoffmann,S. "Heparin induced thrombocytopenia in a medical ICU." In CRITICAL CARE MEDICINE. (December 2002). A129-A129.

Ali,N; Bentley,T; Keuhn,L; Mekhjian,H; Shirk,M,B; Hoffmann,S. "Computerized physiclan-order entry in a medically complex environment elements of a successful implementation." In CRITICAL CARE MEDICINE. (December 2002). A37-A37.

Morales,J,E; Ali,N; Bhatt,N; Hoffmann,S. "Heparin induced thrombocytopenia in a medical ICU." In CRITICAL CARE MEDICINE. (February 2003). A129-A129.

Ali,N; Bentley,T; Keuhn,L; Mekhjian,H; Shirk,M,B; Hoffmann,S. "Computerized physician-order entry in a medically complex environment elements of a successful implementation." In CRITICAL CARE MEDICINE. (February 2003). A37-A37.

Ali,N; Hoffmann,S; Bhatt,N. "Order detail in computerized order entry has a significant impact on ICU workflow." In CRITICAL CARE MEDICINE. (December 2003). A26-A26.

Opalek,J,M; Ali,N; Marsh,C,B. "Chemokine receptor expression and functional significance in alveolar macrophages." In FASEB JOURNAL. (March 2004). A464-A464.

Hixon-Vermillion,B; Havreberg,K; Greene,D; Stegemiller,C; Leasure,J; O'Brien,J; Ali,N. "Multidisciplinary skin care rounds have the potential to decrease dermal pressure ulcer (DPU) rates in critically ill patients.." In CRITICAL CARE MEDICINE. (December 2005). A26-A26.

West,T; Leasure,J; Hixon-Vermillion,B; Hoffmann,S; Aberegg,S; O'Brien,J; Ali,N. "A nurse led bedside quality improvement system can result in improved compliance with VAP prevention.." In CRITICAL CARE MEDICINE. (December 2005). A30-A30.

O'Brien,J,M; Ali,N,A; Lucarelli,M; Marsh,C,B; Phillips,G,S. "Body mass index (BMI) is independently associated with mortality in adults with acute lung injury (ALI) in an observational database." In CRITICAL CARE MEDICINE. (December 2005). A85-A85.

Essig,LeRoy,W; O'Brien,James,M; Ali,Naeem. "Obesity is associated with inadequate dosing of medications used for emergency endotracheal intubation in a medical ICU.." In CRITICAL CARE MEDICINE. (December 2006). A94-A94.

O'Brien,James,M; Ali,Naeem; Hoffmann,Stephen; Marsh,Clay; Lemeshow,Stanley; West,Tabitha; Smith,Randy; Leasure,Jennifer. "The clinical assessment nurse (CAN) improves utilization of the ventilator bundle during the first 24 hours after intensive care unit (ICU) admission.." In CRITICAL CARE MEDICINE. (December 2006). A132-A132.

Ali,Naeem,A; O'Brien,James,M; Blum,William; Klisovic,Rebecca,B; Marcucci,Guido; Phillips,Gary; Marsh,Clay,B; Lemeshow,Stanley; Byrd,John,C; Grever,Michael,R. "Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality.." In BLOOD. (November 2006). 476B-476B.

Ali,Naeem,A; O'Brien,James,M; Blum,William; Byrd,John,C; Klisovic,Rebecca,B; Marcucci,Guido; Phillips,Gary; Marsh,Clay,B. "Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality." In CANCER. (July 2007). 96-102.

Ali,Naeem; O'Brien,James; Dungan,Kathleen; Phillips,Gary; Marsh,Clay; Lemeshow,Stanley; Connors,Alfred; Preiser,Jean-Charles. "Glucose variability is independently associated with mortality in patients with sepsis." In CRITICAL CARE MEDICINE. (December 2007). A257-A257.

Riscili,Brent,P; Dakhlallah,Duaa; McMaken,Sara; Ali,Naeem; Hunter,Melissa; Marsh,Clay,B; Karsies,Todd. "MICRO-RNA PROFILING IN A MURINE MODEL OF SEPSIS.." In CRITICAL CARE MEDICINE. (December 2008). A38-A38.

Schuster,Dara,P; Hall,Christine; Dungan,Kathleen; Ali,Naeem; Vermillion,Brenda. "Use of hospital-wide nurse-managed insulin drip guidelines in a large academic center." In DIABETES. (June 2008). A693-A694.

Riscili,B,P; Karsies,T; McMaken,S; Dakhlallah,D; Ali,N; Hunter,M; Marsh,C,B. "Micro-RNA Expression in a Murine Model of Sepsis." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2009). /-.

McMaken,S; Newland,C,A; Schrader,C,A; Baran,C,P; Marsh,C,B; Ali,N,A. "Lack of Thrombospondin-1 in a Mouse Model of Sepsis Results in Increased Survival.." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2009). /-.

Strack,L,K; O'Brien,J,M; Hoffmann,S,P; Phillips,G; Marsh,C,B; Ali,N,A. "Determinants of Handgrip Strength in Critically Ill Patients: A Secondary Analysis of the Findings from WIRE." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2009). /-.

 

Degrees

1992 B.A., Williams College

1996 M.D., The Ohio State University

 

Editorial Activities

2006 - present Lung
2006 - present Critical Care Medicine
2006 - present Respiration
2006 - present Pediatrics
2007 - present Critical Care
2007 Journal of Clinical Oncology
2008 - present Intensive Care Medicine
2009 - present The American Journal of Respiratory and Critical Care Medicine
2013 - present Journal of Critical Care
 

Honors

1995 Alpha Omega Alpha Medical Honor Society. Gamma Chapter.
2000 - 2001 Citizenship Award.
2002 - 2003 The James V. Warren Award. College of Medicine, Department of Internal Medicine.
2002 - 2003 NIH National Research Service Award-Research Citation Finalist. NIH, under PACCS Division administration.
2003 Best Research Presentation by a Clinical Fellow. Bennett Society Research Day.
2004 - 2005 Buckeye Adult Lung (BAL) Award. Pulmonary, Allergy, Critical Care & Sleep Division.
2006 Forty Under 40. Business First.
2007 America’s Best Doctors.
2008 Chair, International Committee to determine consensus definitions in ICU-acquired weakness. American Thoracic Society.
2011 Med I/II Integrated Pathway Program Faculty Recognition Award. Integrated Pathway Program.
2013 Excellence in Teaching Award. College of Medicine.
 

Journal Articles

Ali, Naeem, A; Mekhjian, Hagop, S; Kuehn, P Lynn; Bentley, Thomas, D; Kumar, Rajee; Ferketich, Amy, K; Hoffmann, Stephen P. "Specificity of computerized physician order entry has a significant effect on the efficiency of workflow for critically ill patients.." Critical care medicine. Vol. 33, no. 1. (March 2005.): 110-114.

Ali, Naeem, A; O'Brien, James; Hoffmann, Stephen. "Critical illness polyneuropathy." Critical care medicine. Vol. 33, no. 7. (July 2005.): 1674-5; author reply 1675.

Magro, Cynthia; Ali, Naeem, A; Williams, JoAnna, D; Allen, James, N; Ross, Patrick Jr. "Cytomegalovirus-associated pulmonary septal capillary injury sine inclusion body change: a distinctive cause of occult or macroscopic pulmonary hemorrhage in the immunocompetent host.." Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry. Vol. 13, no. 3. (September 2005.): 268-272.

O'Brien, James M Jr; Ali, Naeem, A; Abraham, Edward. "Year in review in Critical Care, 2004: sepsis and multi-organ failure.." Critical care (London, England). Vol. 9, no. 4. (August 2005.): 409-413.

O'Brien, James M Jr; Phillips, Gary, S; Ali, Naeem, A; Lucarelli, Maria; Marsh, Clay, B; Lemeshow, Stanley. "Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury.." Critical care medicine. Vol. 34, no. 3. (March 2006.): 738-744.

O'Brien, James M Jr; Lu, Bo; Ali, Naeem, A; Martin, Greg, S; Aberegg, Scott, K; Marsh, Clay, B; Lemeshow, Stanley; Douglas, Ivor S. "Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients.." Critical care medicine. Vol. 35, no. 2. (February 2007.): 345-350.

Ali, Naeem, A; O'Brien, James M Jr; Blum, William; Byrd, John, C; Klisovic, Rebecca, B; Marcucci, Guido; Phillips, Gary; Marsh, Clay, B; Lemeshow, Stanley; Grever, Michael R. "Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality.." Cancer. Vol. 110, no. 1. (July 2007.): 96-102.

O'Brien, James M Jr; Ali, Naeem, A; Aberegg, Scott, K; Abraham, Edward. "Sepsis." The American Journal of Medicine. Vol. 120, no. 12. (December 2007.): 1012-1022.

Judy M. Opakek, Naeem Ali, Clay B. Marsh. "Alveolar macrophages lack CCR2 expression and do not functionally respond to monocyte chemoattractant protein-1." Journal of Inflammation. no. 4. (September 2007.): 19-.

Naeem A. Ali, James M. O’Brien, Jr, Stephen P. Hoffmann, Gary Phillips, Allan Garland, James C.W. Finley, Khalid Almoosa, Rana Hejal, Karen M. Wolf, Stanley Lemeshow, Alfred F. Connors Jr, Clay B. Marsh. "Acquired weakness, handgrip strength and mortality in critically ill patients." American Journal of Respiratory and Critical Care Medicine. Vol. 178, no. 3. (August 2008.): 261-268.

Ali, Naeem, A, O'Brien JM Jr, Dungan K, Phillips G, Marsh CB, Lemeshow S, Connors AF Jr, Preiser JC.. "Glucose variability and mortality in patients with sepsis." Critical Care Medicine. Vol. 8, no. 36. (August 2008.): 2316-2321.

James M. O'Brien, Jr, Naeem A. Ali, Edward Abraham. "Year in review 2007: Critical Care - multiple organ failure and sepsis." Critical Care. Vol. 5, no. 12. (October 2008.): 225-228.

Naeem A. Ali. "Moving toward preventive therapy in acute lung injury." Critical Care Medicine. Vol. 5, no. 36. (May 2008.): 1666-1667.

Ali NA, Bickerstaff A, Licktenberger F, Flavahan N, Kaumaya P, Orosz CG, Marsh CB. "Latency Associated Peptide has In Vitro and In Vivo Biological Effects Independent of TGF-Beta." PLoS ONE. Vol. 4, no. 3. (April 2008.): e1914-.

O'Brien JM Jr, Aberegg SK, Ali NA, Diette GB, Lemeshow S. "Results from the national sepsis practice survey: predictions about mortality and morbidity and recommendations for limitation of care orders." Critical Care. Vol. 3, no. 13. (June 2009.): R96-.

Ali, Naeem, A, O'Brien Jr, James M, et al.. "Can Hand Dynamometry Serve as a Simple Test to Identify ICU-acquired Paresis?." Am J Respir Crit Care Med. Vol. 4, no. 179. (February 2009.): 329-330.

Robert D. Stevens, MD; Scott A. Marshall, MD; David R. Cornblath, MD; Ahmet Hoke, MD, PhD;Dale M. Needham, MD, PhD; Bernard de Jonghe, MD; Naeem A. Ali, MD; Tarek Sharshar, MD, PhD. "A framework for diagnosing and classifying intensive care unit acquiredweakness." Critical Care Medicine. Vol. Supplement, no. 37. (October 2009.): S299-S308.

Ali, Naeem, A. "How Strong is Weakness?." Critical care Medicine. Vol. 12, no. 37. (December 2009.): 3173-3174.

O'Brien JM Jr, Aberegg SK, Naeem A. Ali, Diette GB, Lemeshow S. "Results from the National Sepsis Practice Survey: Use of drotrecogin alpha (activated) and other therapeutic decisions." Journal of Critical care. no. epub ahead of print. (June 2010.): -.

Ali, Naeem, A. "Have we found the prevention for intensive care unit acquired paresis?." Critical care. Vol. 3, no. 14. (May 2010.): 160-.

Ezzie ME, Piper MG, Montague C, Newland CA, Opalek JM, Baran C, Naeem A. Ali, Brigstock D, Lawler J, Marsh CB.. "Thrombospondin-1 Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis." American Journal of Respiratory and Cellular Molecular Biology. no. epub ahead of print. (June 2010.): -.

Sara McMaken, Matthew E. Exline, Anasuya Sarkar, Melissa Piper, Clay Marsh Charles Cook and Naeem A. Ali. "Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity." PLoS ONE. Vol. 5, no. 6. (May 2011.): e19654-.

Naeem A. Ali, David Gutteridge, Sajid Shahul, William Checkley, Jonathan Sevransky, Greg S. Martin. "Critical illness outcome study: an observationalstudy of protocols and mortality in intensivecare units." Open Access Journal of Clinical Trials. Vol. 3, (September 2011.): 55-65.

Naeem A. Ali, Ted Warren, James M. O'Brien, Karen Wolf, Mitch Rashkin, Jeff Hammersley, Stephen Hoffmann, Gary Phillips and Allan Garland. "Continuity of Care in Intensive Care Units: A Cluster-Randomized Trial of Intensivist Staffing." American Journal of Respiratory and Critical Care Medicine. (January 2011.): -.

Brent P. Riscili, Tyler B. Anderson, Hallie C. Prescott, Matthew C. Exline, Madhuri M. Sopirala, Gary S. Phillips and Naeem A. Ali. "An Assessment of H1N1 Influenza-Associated Acute Respiratory Distress Syndrome Severity after Adjustment for Treatment Characteristics." PLoSONE. Vol. 6, no. 3. (March 2011.): e18166-.

James M. O'Brien Jr, Bo Lu, Naeem A. Ali, Deborah A. Levine, Scott K. Aberegg and Stanley Lemeshow. "Insurance type and sepsis-associated hospitalizations and sepsis-associated mortality among U.S. adults: a retrospective cohort study." Critical Care. Vol. 15, no. 3. (May 2011.): R130-.

Ali NA, Hammersley J, Hoffmann SP, O'Brien JM Jr, Phillips GS, Rashkin M, Warren E, Garland A. "Continuity of Care in Intensive Care Units: A Cluster-Randomized Trial of Intensivist Staffing." Am J Respir Crit Care Med.. Vol. 184, no. 7. (October 2011.): 803-8.

O'Brien JM Jr, Philips GS, Ali NA, Marsh CB. "The Association Between Body Mass Index, Processes of Care, and Outcomes from Mechanical Ventilation: A Prospective Cohort Study." Critical Care Medicine. Vol. 40, no. 5. (May 2012.): 1456-63.

Exline, MC, Ali, NA, Zikri, N, Mangino, JE, Torrence, K, Vermillion, B, St. Clair, J, Lustberg, M, Preeti, Pancholi, Sopirala, MM. "Beyond the Bundle- Journey of a Tertiary Care Medical Intensive Care Unit to Zero Central Line Associated Bloodstream Infections." Critical Care. Vol. 17, no. 2. (April 2013.): R41-.

Sopirala, MM, Haas, DM, Ali, NA, Mangino, JE, Pan, X, Turner, AN. "Effect of Fever on Hospital Presentation, Diagnosis, and Treatment in Patients with H1N1/09 Influenza." Journal of Hospital Medicine. Vol. 8, no. 1. (January 2013.): 20-24.

Stawicki, S, Adkins, E, Eiferman, D, Ali, N et al.. "Prospective Evaluation of Intravascular Volume Status in Critically Ill Patients: Does IVC Collapsibillity Correlate with CVP?." J Trauma. Vol. /, (August 2013.): /-.

Wunsch, H, Christiansen, C, Johansen, M, Olsen, M, Ali, N, Angus, D, Toft Sorensen, H. "Psychiatric Diagnoses and Psychoactive Medication Use Among Nonsurgical Critically Ill Patients Receiving Mechanical Ventilation." JAMA. Vol. 311, no. 11. (March 2014.): 1133-1142.

Parsons, E, Caldwell, E, Watkins, TW, Vande Vusse, L, Heckbert, SR, Kriss, EK, Ali, NA, Hough, CL. "Red Blood Cells Transfusion is Associated with Decreased In-Hospital Muscle Strength AMong Criticall Ill Patients Requiring Mechanical Ventilation." Journal of Critical Care. -.

Shulan, JM, Ali, NA. "Barium Sulfate Aspiration." J AM Osteopath Assoc.. -.

 

Reference Works

January 2002 Naeem A. Ali MD, J Allen, A Pope-Harman, P Ross, C Magro."Cytomegalovirus-associated Pulmonary Microangiopathy in the Normal Adult: An Emerging Cause of Alveolar Hemorrhage" Atlanta, GA.
January 2002 Naeem A. Ali MD, Frank Lichtenberger, Nicholas Flavahan, Clay Marsh."TGF-B Latency Associated Peptide (LAP) Induces Monocyte Chemotaxis" Atlanta, GA.
January 2003 Naeem A. Ali, Lynn Kuehn, Tom Bentley, Mary Beth Shirk, Hapgo Mekhjian, Stephen Hoffmann."Implementation of a computerized physician order entry system in a complex medical environment: elements of successful use in the ICU" San Antonio, TX.
January 2003 Naeem A. Ali MD, Frank Lichtenberger, Clay B. Marsh MD."TGF-B Latency-associated Peptide (LAP) Induced Monotype Chemotaxis is mediated through interactions with TSP-1" .
January 2003 Juan E. Morales, Naeem A. Ali, Nitin Bhatt, Stephen Hoffmann."Incidence and outcomes of HITT in patients with thrombocytopenia in a Medical ICU" San Antonio, TX.
January 2004 Naeem A. Ali, Lynn Kuehn, Tom Bentley, Mary Beth Shirk, Hagop Mekhjian, Stephen Hoffmann."Order Detail in CPOE has a significant impact on workflow in the ICU" .
January 2004 Naeem A. Ali MD, Frank Lichtenberger, Clay B. Marsh MD."TGF-B Latency-associated Peptide (LAP) cna independently act as an immunomodulatory molecule" .
January 2006 Brenda Hixon-Vermillion, Jennifer Leasure, Debbie Green, Christie Stegemiller, Naeem A. Ali."The effect of a bedside skin-care rounds on DPU rates in the ICU" .
January 2006 Tabitha West, Jennifer Leasure, James O'Brien Jr, Scott K. Aberegg, Naeem A. Ali."The effect of a bedside quality assurance auditor on improving compliance with VAP-prevention practices" .
May 2007 Naeem Ali, James O'Brien, Jean-Charles Preiser."Glucose variability and mortality in sepsis patients" .
May 2007 Naeem Ali, Frank Lichtenberger, Clay Marsh."Thrombospondin is important in determining survival after induction of a murine model of sepsis" .
January 2008 Lindsay Pell, Kari Mount, Naeem A. Ali."Experience with Dexmedetomidine in a Medical Intensive Care Unit" .
May 2008 Naeem Ali, Kathleen Dungan, James O'Brien, Jean-Charles Preiser."Early glucose variability is associated with subsequent hypoglycemia in sepsis patients" .
May 2008 Naeem Ali, James O'Brien, et al."Acquired weakness, handgrip strength and mortality in critically ill patients" .
May 2008 Michael Green, Leanne Strack, Clay Marsh, Naeem Ali."Clinical determinants of handgrip strength in critically ill patients" .
May 2008 J.M. O'Brien, M.D., M.Sc., M. Kearns, M.D., S.K. Aberegg, M.D., M., Naeem A. Ali, M.D., C.B. Marsh, M.D., S. Lemeshow, Ph.D."Factors Associated with Predicted Mortality of Septic Shock Patients: Results from the National Sepsis Practice Survey" . : A958
May 2008 J.M. O'Brien, B. Lu, Naeem A. Ali, S.K. Aberegg, C.B. Marsh, S. Lemeshow."Patients with Medicare and Medicaid Are at Increased Risk of Sepsis and Sepsis-Related Death" . : A639
May 2008 Eric Adkins, Matthew Exline, James O'Brien, Michael Sayre, Naeem A. Ali."Clinical Characteristics of In-Hospital Cardiac Arrest Patients Surviving to Hospital Discharge" .
May 2009 L.K. Strack, DO, J.M. O'Brien Jr, MD, S.P. Hoffmann, MD, G. Phillips, MAS, C.B. Marsh, MD, Naeem A. Ali, MD."Determinants of Handgrip Strength in Critically Ill Patients: A Secondary Analysis of the Findings from WIRE" . : A1585
May 2009 S. McMaken, MS, C.A. Newland, C.A. Schrader, BS, C.P. Baran, PhD, C.B. Marsh, MD, Naeem A. Ali, MD."Lack of Thrombospondin-1 in a Mouse Model of Sepsis Results in Increased Survival" . : A5730
May 2009 D.J. Wirtz, MD, H.C. Prescott, MD, Naeem A. Ali, MD, J.P. Parsons, MD, J.G. Mastronarde, MD."A Retrospective Analysis of Asthma Admissions at an Academic Medical Center in the Midwest" . : A1301
May 2009 B.P. Riscili, MD, T. Karsies, MD, S. McMaken, D. Dakhlallah, Naeem A. Ali MD, M. Hunter, PhD, C.B. Marsh, MD."Micro-RNA Expression in a Murine Model of Sepsis" . : A1165
March 2010 Madhuri Sopirala, Douglas Haas, Naeem A. Ali, Brent Riscili, Jeff Pan and Julie Mangino."Predictors of Disease Severity and Mortality in Hospitalized Patients with Novel H1N1 Influenza" .
May 2010 E.J. Adkins, MD, J.D. Huet, MD, S. Rahmanian, MD, B. Riscili, MD, V. Tarver, BS, J.W. McCallister, MD, J.G. Mastronarde, MD, Naeem A. Ali, MD."Clinical Factors Associated with Step-down Unit Request at ICU Discharge" . : A1658
May 2013 McCann, E, Mieczkowski, B, Exline, M, Patterson, E, Vermillion, B, Ali, N."The American Journal of Respiratory and Critical Care Medicine" /.
January 2013 Mieczkowski, B, Buchman, T, Farmer, C, Lilly, C, Ali, N et al."Society of Critical Care medicine International Congress" /.
April 2013 Wright, N, Moffatt-Bruce, S, Ali, N."International Patient Safety Conference" /.
May 2013 McCann, E, Westermann, R, McCallister, J, Mieczkowski, B, Exline, M, Patterson, E, Vermillion, B, Ali, N."The American Journal of Respiratory and Critical Care Medicine" /.
January 2014 Ali, N."Incidence of Nephrotoxicity in Critically Ill Patients Receiving Tobramycin Versus a Control Group" /.
January 2014 Ali, N."Clinical Hypotension with Etomidate or Ketamine Used for Intubation in a Medical Intensive Care Unit" /.

Softwares

Naeem Ali, James O'Brien, Stephen Hoffmann, John Mastronarde."The ICU Minimum Dataset" OSU Information Warehouse: Intranet
Naeem Ali, James O'Brien, John Mastronarde, Matthew Exline, Beth Besecker."The ICU Sepsis Minimum dataset" OSU Information Warehouse

Presentations

"Finding A Fellowship in Internal Medicine." Presented at ACP_ASIM Ohio Chapter Scientific Meeting, . (October 2000)

"Acute Eosinophilic Pneumonia." Presented at Ohio Thoracic Society Case Conferrence, . (September 2000)

"Careers in Internal Medicine." Presented at AED Honors Pre-Medical Society, OSU Chapter, . (January 2001)

"Primary Pulmonary Hypertension presenting with Sudden Death, Diffuse Alveolar Hemorrhage." Presented at Ohio Thoracic Society Case Conferrence, . (October 2001)

"Computerized Physician Order Entry: Its not just about medication error reduction." Presented at Siemens Financial Health Executives Forum, . (May 2002)

"Computerized Physician Order Entry: Its not just about medication error reduction." Presented at American Society of Hospital Pharmacists Meeting, . (December 2003)

"Moderate and Deep Sedation." Presented at OSU Mednet, Columbus, OH, US|USA. (January 2004)

"Updateon Venous Thromboembolism Diagnosis." Presented at OSU MedNet, . (May 2005)

"Delirium in the ICU." Presented at OSU MedNet, . (August 2005)

"COPD Mimics." Presented at OSU Pulmonary and Critical Care CME course, Columbus, OH, US|USA. (January 2005)

"Ventilator liberation: what’s the hurry?." Presented at Current Concepts in Respiratory Care, Columbus, OH, US|USA. (January 2006)

"Acquired neuromuscular disease in the ICU." Presented at Critical Care State of the Art update, Indianapolis, IN, US|USA. (January 2007)

"Advance Tools for Critical Care Delivery." Presented at American Thoracic Society Meeting 2007, San Francisco, CA, US|USA. (May 2007)

"Immediate outcomes from ICU-acquired weakness." Presented at Advances in Respiratory Care, Columbus, OH, US|USA. (March 2008)

"Immediate outcomes from ICU-acquired weakness." Presented at ICU outcomes, Columbus, OH, US|USA. (January 2008)

"Immediate outcomes from ICU-acquired weakness." Presented at American Thoracic Society Meeting 2008, Toronto, CA. (May 2008)

"Clinical Determinants of Handgrip Strength in critically ill patients." Presented at ICU-physical therapy, North-American Conference, Toronto, ON. (May 2008)

"Assessing Strength in the ICU." Presented at ATS international Conference 2008, Toronto, ON. (May 2008)

"Consensus panel for clinical recemmendations on the assessment of ICU-acquired weakness." Presented at Consensus panel for clinical recemmendations on the assessment of ICU-acquired weakness, San Diego, CA, US|USA. (January 2009)

"Ventilator weaning in ICU-acquired Weakness." Presented at Current Concepts in Respiratory Care, Columbus, OH, US|USA. (March 2009)

"Consensus definitions of ICU-acquired weakness: clinical questions and background literature review." Presented at ATS Consensus conference on the clinical definition of ICU-acquired weakness, San Diego, CA, US|USA. (May 2009)

"Interventions to prevent ICU-acquired weakness." Presented at International Society of Intensive Care and Emergency Medicine Annual Meeting, Brussels, BE|BEL. (March 2010)

"Glucose variability in critically ill patients." Presented at International Society of Intensive Care and Emergency Medicine Annual Meeting, Brussels, BE|BEL. (March 2010)

"The utility of handgrip testing to predict outcomes in ICU patients." Presented at ICU-acquired weakness: A current state of the art, New Orleans, LA, US|USA. (May 2010)

"Consensus panel for clinical recemmendations on the assessment of ICU-acquired weakness." Presented at ATS Consensus conference on the definitions and assessments of ICU-acquired weakness, New Orleans, LA, US|USA. (May 2010)

"Consensus definitions of ICU-acquired weakness: focus areas and GRADE methodology." Presented at ATS Consensus conference on the definitions and assessments of ICU-acquired weakness, New Orleans, LA, US|USA. (May 2010)

"Comparison of Alternative Intensivist Staffing Schedules on Physician and Patient Outcomes in the Intensive Care Unit." Presented at Mini-Symposium/ A15-Intensive Care Unit Staffing/ ATS 2011, Denver, CO, US|USA. (May 2011)

"Continuity of Care After the ICU." Presented at 7th International Symposium on Intensive Care and Emergency Medicine for Latin America- ISICEM, . (March 2014)

"Rescue of Medically Complex Patients." Presented at 7th International Symposium on Intensive Care and Emergency Medicine for Latin America- ISICEM, . (March 2014)

 

Professional Activities

present Program Review Subcommittee. American Thoracic Society, 2011.
present Program Review Subcommittee. American Thoracic Society. Tampa Bay, Florida, 2012.
2005 - present The Protection of Human Subjects in Clinical Trials in Critical Care. The National Institutes of Health. Washington, DC.
2007 - present Planning Committee Participation, Investigator's meeting BAA initiative. Clinical Research Collaborative Group, BAA initiative, using electronic systems to improve the delivery of clinical critical care.. Salt Lake City, UT.
2008 - present The Inaugural meeting of the US Critical Illness and Injuries Trials Group. US Critical Illness and Injuries Trials Group (USCIITG). Bethesda, MD.
2009 - present Radio Interview. WOSU. Columbus, OH.
2009 - present Interview about ICU-acquired weakness. New York Times. Columbus, OH.
2009 - present Chair, Consensus panel to refine the clinical diagnosis of ICUAW. The American Thoracic Society.
2009 - present University of Toledo Health System, College of Medicine. Toledo, OH.
2009 - present Consensus Panel on the definitions and assessments used to diagnose ICU-acquired weakness. The American Thoracic Society. San Diego, CA.
2009 - present Program Review Subcommittee. American Thoracic Society.
2010 - present Program Review Subcommittee. American Thoracic Society. Tampa Bay, FL.
2010 - present Consensus panel on the assessments and definitions of ICU-acquired weakness. The American Thoracic Society. New Orleans, LA.
2011 - present NMES to Reduce Muscle Atrophy in Critically Ill Patients. PI Rik Gosselink, FWO (Research Foundation of Flanders, Brussels, Belgium.
2011 - present Impact of Insulin Therapy on ICUAW: a Prospective Observational Cohort Study.. PI Greet Hermanns, agency for which review was performed: Research Foundation of the University of Leuven.
2011 - present Grant Reviewer. Katholieke Universiteit Leuven, Leuven, Belgium.
2003 - 2005 Representative to the Ohio Chapter of the ALA. Ohio Chapter of the ALA. Columbus, OH.
2003 - 2008 Member of Planning Committee for Midwest Critical Care Consortium. The Midwest Critical Care Consortium. Columbus, OH.
2006 - 2008 SCCM ICU Design Citation Committee. Society of Critical Care Medicine. Washington DC, DC.
2007 - 2008 Program Review Subcommittee. American Thoracic Society.
2007 - 2008 Program Review Subcommittee. The American Thoracic Society. New York, NY.
2009 - 2011 Program Review Subcommittee, member. The American Thoracic Society. Chicago, IL.