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Matthew Exline, MD


Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: exline.16@osu.edu

 

Current OSU Appointments

Assistant Professor-Clinical, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

 

Clinical Interest

Asthma

Critical Care

Sepsis

Pulmonary infections including tuberculosis and nontuberculous mycobacterium and fungal infections

Creative Works

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Biographical

I came to Ohio State for residency after matriculating from the University of Nevada in 2000. After my residency in Internal Medicine and fellowship in Pulmonary, Critical Care, and Sleep I joined the Department of Internal Medicine as an Assistant Professor on the clinical track in 2006 as a clinician scholar.

Academic Advising

2011 - present Sindhu Mukku The Ohio State University.
2012 - present Joseph Duffy The Ohio State University.
2013 - present The Ohio State University.
2007 - 2009 Leanne Strack The Ohio State University. Graduated 2009.
2008 - 2010 Eric Adkins The Ohio State University. Graduated 2010.
2009 - 2012 Michael Chacey The Ohio State University. Graduated 2012.
 

Certifications

2003 - present Medical License: State Medical Board of Ohio
2003 - present Internal Medicine: American Board of Internal Medicine
2005 - present Pulmonary Disease: American Board of Internal Medicine
2006 - present Critical Care: American Board of Internal Medicine
2007 - present Fundamentals of Critical Care Support: Society of Critical Care Medicine
2011 - present Sleep Medicine: American Board of Internal Medicine
2012 - present Difficult Airway Management: A Critical Care Approach: American College of Chest Physicians
2014 - present Advanced Cardiac Life Support (ACLS): The Ohio State University
2004 - 2007 Advanced Trauma Life Support: The Ohio State University
 

Chapters in Books

Crouser, ED, Exline, M, Fahy, RJ. "Acute Lung Injury, Pulmonary Edema, and Multiple System Organ Failure." In Egan's Fundamentals of Respiratory Care 10th Edition. -. St Louis: Mosby Elsevier, January 2012.

 

Clinical Services

07/01/2006 In-Patient Medical Center Service - 20-25% FTE (8ICU, MICU, Ross, James, OSU East, OSU Main)
07/01/2007 Outpatient Clinic - 10% FTE (Martha Morehouse Medical Plaza)

Conferences

Exline, M, Fahy, R, Gavrilin, MA, Duncan, MD, Wewers, MD. "Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients." In Proceedings of the American Thoracic Society. (May 2006). A328-.

Exline, M, Fah,y RJ, Hall, MW, Bhatt, NY, Wewers, MD. "Plasma Caspase-1 Levels Elevated in Patients with Septic Shock." In Proceedings of the American Thoracic Society. (May 2007). A440-.

Strack, LK, Sarkar, A, Exline, M, Wewers, MD. "Whole Blood Responses to Pathogenic Versus Nonpathogenic E. coli: Bacterial Killing Efficiency and Cytokine Profiling." In Proceedings of the American Thoracic Society. (May 2008). A432-.

Exline, M, Besecker, BY, Hollyfield, JL, Gavrilin, MA, Fahy, RJ, Wewers, MD. "Inflammasome mRNA Expression in Critically Ill Patients." In Proceedings of the American Thoracic Society. (May 2008). A123-.

Besecker, BY, Exline, M, Hollyfield, JL, Josephs, E, DiSilvestro, RA, Knoell, DL. "Modulation of Zinc Homeostasis Via Zinc Transporters in Humans with Sepsis." In Proceedings of the American Thoracic Society. (May 2008). A120-.

Exline,M, Hollyfield, J, Gavrilin, M, Nana-Sinkam, S, Wewerss, M. "Cigarette Smoke Extract Suppresses Innate Immune Response in Peripheral Blood Monocytes.." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2009). /-.

Pell,Lindsay; Mount,Kari; Doepker,Bruce; Exline,Matthew. "ACHIEVING ADEQUATE AMIKACIN LEVELS IN A MEDICAL INTENSIVE CARE UNIT." In CRITICAL CARE MEDICINE. (December 2009). A405-A405.

Exline, M, Sarkar, A, Besecker,B, Hollyfield,J, Mitra,S, Wewers, M. "Inflammasome Constituents Released Via Microvesicles During Sepsis." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2010). /-.

Exline,M, Hollyfield,J, Besecker,B,Y, O'Brien,J, Ali,N, Wewers, M. "Pathogen Sensor NLRP3 Suppressed During Sepsis And Improves During Recovery." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2011). /-.

Chacey,M, Exline,M, Hollyfield,J, Wewers, M. "Serum And Alveolar LL-37 Is Elevated In Respiratory Failure Patients But Not In Septic Patients." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2011). /-.

Torrence, K, Vermillion, B, St. Clair, J, Zikri, N, Sopirala, M, Ali, N, Exline, M. "The Power of Team: Utilizing A Multi-Faceted, Interdisciplinary Approach To Reduce Central Line Associated Blood Stream Infections." In Critical Care Medicine. (February 2011). 161-.

Russo, AN, Wewers, MD, Fahy, R, Hollyfield, J, Exline, M. "Severity Of Illness, Not Pathogen Determines Suppression Of Pathogen Sensors In Sepsis." In Am J Respir Crit Care Med. (May 2012). A5761-.

Besecker, BY, Zakharova, E, Hollyfield, J, Exline, M. "Sepsis Outcomes May Improve In Patients With Improved Plasma Zinc Concentration ICU Day Five." In Am J Respir Crit Care Med. (May 2012). A5765-.

Exline, M, Hollyfield, J, Besecker, B, Ali, N,O'Brien, JM, Wewers, MD. "NOD1 And NOD2 Message Suppressed In Septic Patient Monocytes." In American Journal of Respiratory and Critical Care Medicine. (May 2012). A5764-.

Haas,E, Taylor,J, Ali,N, Exline,M. "Does a Negative Gram Stain Predict the Absence of Potentially Resistant Organisms?." In CHEST. (October 2013). /-.

Exline, M, Justiniano, SE, Hollyfield, J, Besecker, BY, Ali, N, Mitra, S, Wewers, MD, Sarkar, A.. "Sepsis Triggers Release Of Microvesicles Containing Caspase-1 In Active Form." In Am J Respir Crit Care Med. (May 2013). A2786-.

Van Berkel,Megan; Exline,Matthew; Mount,Kari; Ryder,Lindsay; Philips,Gary; Ali,Naeem; Doepker,Bruce. "Clinical hypotension with etomidate or ketamine used for intubation in a medical intensive care unit." In CRITICAL CARE MEDICINE. (December 2013). n/a-.

Mukku,Sindhu; Kynyk,Jessica; Exline,Matthew. "A Rare Case of Sarcoidosis of the Tongue in a Patient With Occupational Beryllium Exposure." In CHEST. (October 2013). A660-.

Westman, RP, McCann, E, Mieczkowski, BP, Exline, M, Patterson, E, Vermillion, B, Ali, N. "Intensivist And Resident Team Situational Awareness Improves Over Four Weeks Of An ICU Rotation." In Am J Respir Crit Care Med. (May 2013). A1599-.

McCann, E, Mieczkowski, BP, Exline, M, Patterson, E, Vermillion, B, Ali, N. "Measurement Of Team Situational Awareness Across Disciplines After Multidisciplinary ICU Rounds." In Am J Respir Crit Care Med. (May 2013). A1597-.

Justiniano, SE, Berhe, F, Exline, M, Chacey, M, Wewers, MD, Sarkar, A. "LL37 Induces Microvesicular Caspase-1 And IL-1β Release And Cell Injury." In Am J Respir Crit Care Med. (May 2013). A4195-.

 

Degrees

1996 B.S., University of Nevada

2000 M.D., University of Nevada

2012 M.Public Hlth., The Ohio State University

 

Editorial Activities

2006 - present Respiration
2007 - 2009 Proceedings of the American Thoracic Society
2008 - present Recent Patents on Inflammation & Allergy Drug Discovery
2008 - present Lung
2009 - present Critical Care
2009 - present American Thoracic Society Web Case of the Month
2012 - present Journal of Clinical Oncology
 

Honors

1998 - present Outstanding Student. Behavorial Sciences.
1998 - present Outreach Clinic Award for Service. University of Nevada.
2000 - present Alpha Omega Alpha Medical Honor Society. AOA.
2000 - present Graduation Guest Speaker. Class of 2000.
2003 - present Gorilla Award. Department of Internal Medicine.
2005 - present Best Case Report in Cancer Case I. ACCP Chest 2005.
2009 - 2014 Best Doctors in America. Best Doctors, Inc..
2010 - present Faculty Teaching Award in the Critical Care Setting. Department of Internal Medicine.
2013 - present Buckeye Adult Lung Award - Excellence in Fellowship Teaching. Division of Pulmonary, Allergy, Critical Care, and Sleep.
2014 - present Exceptional Physician Peer Award. Physician Faculty Engagement Committee.
2014 - present Faculty Teaching Award in Critical Care. Ohio State University Department of Internal Medicine.
 

Journal Articles

Sarkar, A, Hall, MW, Exline, M, Hart, J, Knatz, N, Gatson, N, Wewers, MD. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1 beta and interleukin-18." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 174, no. 9. (November 2006.): 1003-1010.

Benninger, C, Mastronarde, JG, Exline, M. "A 39-year-old woman with intractable asthma.." Chest. Vol. 132, no. 4. (January 2007.): 1397-1400.

Exline, M, Magro,C, Lin, T, Sood, N. "Pulmonary hypertension in Hodgkin's disease." THORAX. Vol. 62, no. 4. (April 2007.): 371-371.

Crouser, ED, Exline, M, Knoell, D, Wewers, MD. "Sepsis: Links between pathogen sensing and organ damage." CURRENT PHARMACEUTICAL DESIGN. Vol. 14, no. 19. (July 2008.): 1840-1852.

Fahy, RJ, Exline, M, Gavrilin, MA, Bhatt, NY, Besecker, BY, Sarkar, A, Hollyfield, JL, Duncan, MD, Nagaraja, HN, Knatz, NL, Hall, M, Wewers, MD ,. "Inflammasome mRNA expression in human monocytes during early septic shock.." American Journal of Respiratory and Critical Care Medicine. Vol. 177, no. 9. (January 2008.): 983-988.

Exline, M, Crouser, ED. "Mitochondrial mechanisms of sepsis-induced organ failure." FRONTIERS IN BIOSCIENCE-LANDMARK. Vol. 13, (May 2008.): 5030-5041.

Riscili, BP, Anderson, TB, Prescott, HC, Exline, M, Sopirala, MM, Phillips, GS, Ali, NA. "An Assessment of H1N1 Influenza-Associated Acute Respiratory Distress Syndrome Severity after Adjustment for Treatment Characteristics." PLoS ONE. Vol. 6, no. 3. (March 2011.): e18166-.

McMaken, S, Exline, M, Mehta, P, Piper, M, Wang,Y, Fischer, SN, Newland, CA, Schrader, CA, Balser, SR, Sarkar, A, Baran,CP; Marsh, CB, Cook,CH, Phillips, GS, Ali, NA. "Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity." PLOS ONE. Vol. 6, no. 5. (May 2011.): e19654-.

Besecker, BY, Exline, M, Hollyfield,JL, Phillips,G, DiSilvestro,RA, Wewers, MD; Knoell, DL. "A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission." AMERICAN JOURNAL OF CLINICAL NUTRITION. Vol. 93, no. 6. (June 2011.): 1356-1364.

Exline M, Crouser, ED. "Mitochondrial Dysfunction During Sepsis: Still More Questions Than Answers." Critical Care Medicine. Vol. 39, no. 5. (May 2011.): 1216-1217.

Exline, M, Sopirala, MM. "Preventing CLABSIs Through a Multidisciplinary Team Effort." Anesthesiology News. Vol. 38, no. 10. (October 2012.): 2-.

Asif, M, Exline, M. "Utilization of Hyperbaric Oxygen Therapy and Induced Hypothermia After Hydrogen Sulfide Exposure." Respiratory Care. Vol. 57, no. 2. (February 2012.): 307-.

Exline, M, Ali, NA, Zikri, N, Mangino, JE, Torrence, K, Vermillion, B, St Clair, J, Lustberg, ME, Pancholi, P, Sopirala, MM. "Beyond the bundle - journey of a tertiary care medical intensive care unit to zero central line-associated bloodstream infections.." Critical Care. Vol. 17, no. 2. (March 2013.): R41-.

Exline, M, Justiniano, S, Hollyfield, JL, Berhe, F, Besecker, BY, Das, S, Wewers, MD, Sarkar, A. "Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis In Sepsis." PLOS One. Vol. 9, no. 3. (March 2014.): e90968-.

Checkley, W, Martin, GS, Brown, SM, Chang, SY, Dabbagh, O, Fremont, RD, Girard, TD, Rice, TW, Howell, MD, Johnson, SB, O'Brien, J, Park, PK, Pastores, SM, Patil, NT, Pietropaoli, AP, Putman, M, Rotello, L, Siner, J, Sajid, S, Murphy, DJ, Sevransky, JE; United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study Investigators.. "Structure, process, and annual ICU mortality across 69 centers: United States critical illness and injury trials group critical illness outcomes study*.." Crit Care Med. Vol. 42, no. 2. (February 2014.): 344-.

Exline, M, Masood, S, Sopirala, MM. "A QUALITY IMPROVEMENT IMPERATIVE: ACHIEVING COMMAND OVER HOSPITAL ACQUIRED INFECTIONS IN INTENSIVE CARE UNITS." ADVANCES IN MEDICINE AND BIOLOGY. -.

 

Reference Works

January 2002 Exline, M, O'Dorisio, N, Thomas, A."Suspected Myositis Following DVT as Initial Presentation of Essential Cryofibrinogenemia" Philadelphia.
January 2005 Exline M, Mastronarde JG."Pulmonary Renal Syndrome Seropositive for Both Antieutrophil Cytoplasmic Autoantibodies and Anti-Glomerular Basement Membrane Autoantibodies" /. : 477S
January 2005 Exline, M, Sood, N."Pulmonary Arterial Hypertension: An Unusual Presentation of Hodgkin's Disease" /. : 413S
January 2008 Hollyfield, JL, Gavrilin, MA, Nana-Sinkam, P, Wewers, M, Exline, M."Smokin ICE: Cigarette Smoke Extract Suppresses Inflammation in Peripheral Blood Monocytes Production" /.
January 2008 Besecker, BY, Exline, M, Hollyfield, JL, Fong, L, DiSilvestro, RA, Knoell, DL."Modulation of Zinc Homeostasis via Zinc Transporters in Humans with Sepsis" /.
January 2008 Adkins, E, Exline, M, O'Brien, JM, Sayre, M, Ali, NA."Clinical Characteristics of In-Hospital Cardiac Arrest Patients Surviving to Hospital Discharge" /.
January 2009 Adkins, EJ, Exline, M."Sudden Onset of Wheezing at Work" /.
May 2012 Chacey, M, Exline, M."Pulmonary Toxicity from Bortezomib Successfully Treated with Steroids in a Patient with Acute Myelogenous Leukemia" /.
December 2013 Van Berkel, M, Exline, M, Mount, K, Ryder, L, Phillips, G, Ali, N, Doepker, B."Clinical Hypotension With Etomidate or Ketamine Used for Intubation in Medical Intensive Care Unit" Mount Prospect, IL.
October 2013 Haas, E, Taylor, J, Ali, N, Exline, M."Does a Negative Gram Stain Predict the Absence of Potentially Resistant Organisms?" Chicago, IL. : 386A
October 2013 Mukku, S, Kynyk, S, Exline, M."A Rare Case of Sarcoidosis of the Tongue in a Patient With Occupational Beryllium Exposure" Chicago, IL. : 675A
May 2013 Exline, M, Justiniano, SE, Hollyfield, J, Besecker, BY, Ali, N, Mitra, S, Wewers, MD, Sarkar, A."Am J Respir Crit Care Me" New York. : A2786

Softwares

December 2012 Matthew Exline."American Thoracic Society Assembly Allergy, Immunology, Inflammation Facebook Page / Web profile"
September 2013 Matthew Exline; Jennifer McCallister; John Mastronarde; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine."Pulmonary Medical School" Apples iTunes U

Presentations

"Modulation of Zinc Homeostasis Via Zinc Transporters in Humans with Sepsis.." Presented at American Thoracic Society International Meeting, . (May 2008)

"The Genetics of Sepsis and the Innate Immune System." Presented at American Thoracic Society International Meeting, San Diego, CA, CA, US|USA. (January 2009)

"Diagnosis of Tuberculosis." Presented at Ohio Department of Rehabilitation and Correction, Medical Leadership Quarterly Meeting, London, OH. (January 2010)

"Surviving Sepsis Guidelines – Update." Presented at Multidisciplinary Advances in the Treatment of the Critically Ill Patient (MATCH Conference), Columbus. (January 2010)