Matthew Exline, MD

Current OSU Appointments

Assistant Professor-Clinical, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

Clinical Interest

121

Clinical Interest

121

Clinical Interest

121

Clinical Interest

121

Certifications

2003 - present	Internal Medicine: American Board of Internal Medicine
2005 - present	Pulmonary Disease: American Board of Internal Medicine
2006 - present	Critical Care: American Board of Internal Medicine
2006 - present	Advanced Cardiac Life Support (ACLS): The Ohio State University
2007 - present	Medical License: State Medical Board of Ohio
2007 - present	Fundamentals of Critical Care Support: Society of Critical Care Medicine
2011 - present	Sleep Medicine: American Board of Internal Medicine
2004 - 2007	Advanced Trauma Life Support: The Ohio State University

Chapters in Books

ELLIOTT D. CROUSER, MATTHEW C. EXLINE AND RUAIRI J. FAHY. "Acute Lung Injury, Pulmonary Edema, and Multiple System Organ Failure." In Egan's Fundamentals of Respiratory Care 10th Edition. -. St Louis: Mosby Elsevier, January 2012.

Editorial Activities

2006 - present	Respiration
2007 - 2009	Proceedings of the American Thoracic Society
2008 - present	Recent Patents on Inflammation & Allergy Drug Discovery
2008 - present	Lung
2009 - present	Critical Care
2009 - present	American Thoracic Society Web Case of the Month
2012 - present	Journal of Clinical Oncology

Honors

1996 - present	Herz Gold Medal Award. University of Nevada.
1996 - present	Suma Cum Laude. Physics Department.
1996 - present	Senior Scholar Award. College of Arts and Sciences.
1996 - present	Regents Outstanding Student Award. University of Nevada.
1998 - present	Outstanding Student. Behavorial Sciences.
1998 - present	Outreach Clinic Award for Service. University of Nevada.
2000 - present	Alpha Omega Alpha Medical Honor Society. AOA.
2000 - present	Graduation Guest Speaker. Class of 2000.
2003 - present	Gorilla Award. Department of Internal Medicine.
2005 - present	Best Case Report in Cancer Case I. ACCP Chest 2005.
2008	Fellow. American College of Chest Physicians.
2009	Best Doctors in America. Best Doctors, Inc..
2010 - present	Faculty Teaching Award in the Critical Care Setting. Department of Internal Medicine.
2013 - present	Buckeye Adult Lung Award - Excellence in Fellowship Teaching. Division of Pulmonary, Allergy, Critical Care, and Sleep.

Journal Articles

Sarkar,Anasuya; Hall,Mark,W; Exline,Matthew; Hart,Judy; Knatz,Nina; Gatson,Na,Tosha; Wewers,Mark,D. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1 beta and interleukin-18." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 174, no. 9. (November 2006.): 1003-1010.

Benninger, Cathy; Mastronarde, John, G; Exline, Matthew C. "A 39-year-old woman with intractable asthma.." Chest. Vol. 132, no. 4. (January 2007.): -.

Exline,Matthew; Magro,Cynthia; Lin,Thomas; Sood,Namita. "Pulmonary hypertension in Hodgkin's disease." THORAX. Vol. 62, no. 4. (April 2007.): 371-371.

Fahy RJ*, Exline MC*, Gavrilin MA, Bhatt NY, Besecker BY, Sarkar A, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall M, Wewers MD (*co-first authorship).. "Inflammasome mRNA expression in human monocytes during early septic shock.." American Journal of Respiratory and Critical Care Medicine. Vol. 177, no. 9. (January 2008.): 983-988.

Exline,Matthew,C; Crouser,Elliot,D. "Mitochondrial mechanisms of sepsis-induced organ failure." FRONTIERS IN BIOSCIENCE-LANDMARK. Vol. 13, (May 2008.): 5030-5041.

Crouser,Elliott; Exline,Matthew; Knoell,Daren; Wewers,Mark,D. "Sepsis: Links between pathogen sensing and organ damage." CURRENT PHARMACEUTICAL DESIGN. Vol. 14, no. 19. (July 2008.): 1840-1852.

Crouser ED*, Exline MC*, Knoell DL*, Wewers MD (*co-first authorship). "Sepsis: links between pathogen sensing and organ damage." Current Pharmaceutical Design. Vol. 14, no. 19. (January 2008.): 1840-.

Brent P. Riscili, Tyler B. Anderson, Hallie C. Prescott, Matthew C. Exline, Madhuri M. Sopirala, Gary S. Phillips, Naeem A. Ali. "An Assessment of H1N1 Influenza-Associated Acute Respiratory Distress Syndrome Severity after Adjustment for Treatment Characteristics." PLoS ONE. Vol. 6, no. 3. (March 2011.): e18166-.

McMaken,Sara; Exline,Matthew,C; Mehta,Payal; Piper,Melissa; Wang,Yijie; Fischer,Sara,N; Newland,Christie,A; Schrader,Carrie,A; Balser,Shannon,R; Sarkar,Anasuya; Baran,Christopher,P; Marsh,Clay,B; Cook,Charles,H; Phillips,Gary,S; Ali,Naeem,A. "Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity." PLOS ONE. Vol. 6, no. 5. (May 2011.): e19654-.

Besecker,Beth,Y; Exline,Matthew,C; Hollyfield,Jennifer; Phillips,Gary; DiSilvestro,Robert,A; Wewers,Mark,D; Knoell,Daren,L. "A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission." AMERICAN JOURNAL OF CLINICAL NUTRITION. Vol. 93, no. 6. (June 2011.): 1356-1364.

Matthew C. Exline, Elliott D. Crouser. "Mitochondrial Dysfunction During Sepsis: Still More Questions Than Answers." Critical Care Medicine. Vol. 39, no. 5. (May 2011.): 1216-1217.

Matthew C Exline Madhuri M Sopirala. "Preventing CLABSIs Through a Multidisciplinary Team Effort." Anesthesiology News. Vol. 38, no. 10. (October 2012.): 2-.

Mir Asif, Matthew C. Exline. "Utilization of Hyperbaric Oxygen Therapy and Induced Hypothermia After Hydrogen Sulfide Exposure." Respiratory Care. Vol. 57, no. 2. (February 2012.): 307-.

Exline MC, Ali NA, Zikri N, Mangino JE, Torrence K, Vermillion B, St Clair J, Lustberg ME, Pancholi P, Sopirala MM. "Beyond the bundle - journey of a tertiary care medical intensive care unit to zero central line-associated bloodstream infections.." Critical Care. Vol. 17, no. 2. (March 2013.): R41-.

Reference Works

January 2002	Exline MC, O'Dorisio N, Thomas A."Suspected Myositis Following DVT as Initial Presentation of Essential Cryofibrinogenemia" Philadelphia.
January 2005	Exline MC. Mastronarde JG."Pulmonary Renal Syndrome Seropositive for Both Antieutrophil Cytoplasmic Autoantibodies and Anti-Glomerular Basement Membrane Autoantibodies" . : 477S
January 2005	Exline MC, Sood N."Pulmonary Arterial Hypertension: An Unusual Presentation of Hodgkin's Disease" . : 413S
January 2006	Exline MC, Fahy R, Gavrilin MA, Duncan MD, Wewers MD."Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients" . : A328
January 2007	Exline MC, Fahy RJ, Hall MW, Bhatt NY, Wewers MD.."Plasma Caspase-1 Levels Elevated in Patients with Septic Shock." . : A440
January 2008	Strack LK, Sarkar A, Exline MC, Wewers MD."Whole Blood Responses to Pathogenic Versus Nonpathogenic E. coli: Bacterial Killing Efficiency and Cytokine Profiling" . : A432
January 2008	Besecker BY, Exline MC, Hollyfield JL, Josephs E, DiSilvestro RA, Knoell DL."Modulation of Zinc Homeostasis Via Zinc Transporters in Humans with Sepsis" . : A120
January 2008	Exline MC, Besecker BY, Hollyfield JL, Gavrilin MA, Fahy RJ, Wewers MD."Inflammasome mRNA Expression in Critically Ill Patients" . : A123
January 2009	Adkins EJ, Exline MC."Sudden Onset of Wheezing at Work" .
May 2009	Exline MC, Hollyfield JL, Gavrilin MA, Nana-Sinkam SP, Wewers MD."Cigarette Smoke Extract Suppresses Innate Immune Response in Peripheral Blood Monocytes" . : A4265
January 2009	Pell L, Mount K, Doepker B, Exline MC."Achieving Adequate Amikacin Levels in a Medical Intensive Care Unit" . : S828
May 2010	MC Exline*, A Sarkar*, BY Besecker, JL Hollyfield, S Mitra, MD Wewers."Inflammasome Constituents Released via Microvesicles During Sepsis" . : A1378
January 2011	Torrence, Kelly; Vermillion, Brenda; St. Clair, Jamie; Zikri, Nancy; Sopirala, Madhuri; Ali, Naeem; Exline, Matthew."The Power of Team: Utilizing A Multi-Faceted, Interdisciplinary Approach To Reduce Central Line Associated Blood Stream Infections" . : 161
May 2011	Pathogen Sensor NLRP3 Suppressed During Sepsis and Improves During Recovery."MC Exline, JL Hollyfield, BY Besecker, JM O’Brien, NA Ali, MA Gavrilin" New York. : A2889
May 2011	Michael Chacey MD, Matthew Exline MD, Jennifer Hollyfield MS, Mark D Wewers, MD."Serum and Alveolar LL-37 is Elevated in Respiratory Failure Patients But Not in Septic Patients" n/a. : A2890
May 2012	A.N. Russo, MD, M.D. Wewers, MD, R. Fahy, MD, J. Hollyfield, BS, MS, M.C. Exline, MD."Severity Of Illness, Not Pathogen Determines Suppression Of Pathogen Sensors In Sepsis" New York. : A5761
May 2012	M.C. Exline, MD1, J. Hollyfield, MS2, B.Y. Besecker, MD2, N. Ali, MD2, J. O'Brien, MD MPH2, M.D. Wewers, MD."NOD1 And NOD2 Message Suppressed In Septic Patient Monocytes" New York. : A5764
May 2012	B.Y. Besecker, MD, E. Zakharova, BS, J. Hollyfield, MS, M. Exline, MD."Sepsis Outcomes May Improve In Patients With Improved Plasma Zinc Concentration ICU Day Five" New York. : A5765

Presentations

"Dangerous Medicine: Misconceptions and Realities of Physician Health and Well-being." Presented at OSU Internal Medicine Grand Rounds, . (January 2003)

"Wegener's Granulomatosis presenting with Cerebral Hemorrhage." Presented at Ohio State University CME Course, . (January 2004)

"Inhaled Nitric Oxide." Presented at Ohio State Current Concepts in Respiratory Care, . (January 2004)

"Catastrophis Antiphospholipid Antibody Syndrome." Presented at Ohio Thoracic Society Meeting, . (January 2004)

"Pulmonary Arterial Hypertension: An Unusual Presentation of Hodgkin's Disease." Presented at American College of Chest Physicians, . (January 2005)

"Pulmonary Renal Syndrome Seropositive for Both Antieutrophil Cytoplasmic Autoantibodies and Anti-Glomerular Basement Membrane Autoantibodies." Presented at American College of Chest Physicians, . (January 2005)

"Anti-apoptotic Peptide Humanin Suppressed in Monocytes of Septic Patients." Presented at American Thoracic Society International Meeting, . (January 2006)

"Caspase-1 Knockout Prevents E.coli Induced Mortality and Splenic Cell Apoptosis Unlike IL-1? Knockout and IL-1?/IL-18 Double Knockout." Presented at American Thoracic Society International Meeting, . (January 2006)

"Issues in Pulmonary Disease: Diagnostic Dilemma's - Pulmonary Embolism." Presented at Ohio State University CME Course, . (January 2006)

"Diagnostic Evaluation of Non-Apneic Excessive Daytime Somnulence." Presented at Sleep Fellowship Didactic Lecture Series, . (January 2006)

"Diagnosis and Treatment of Nontuberculous Mycobacterium Infections." Presented at Pulmonary Didactic Lecture, . (January 2007)

"Caspase-1 Link Between Inflammation and Apoptosis in Sepsis." Presented at Ohio State University Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine Research Day, . (January 2007)

"Shock." Presented at Fundamentals of Medicine Lecture Series (Intern Lecture Series), . (January 2007)

"Plasma Caspase-1 Levels Elevated in Patients with Septic Shock." Presented at American Thoracic Society International Meeting, San Francisco. (January 2007)

"Whole Blood Responses to Pathogenic Versus Nonpathogenic E. coli: Bacterial Killing Efficiency and Cytokine Profiling." Presented at American Thoracic Society International Meeting, . (January 2008)

"Modulation of Zinc Homeostasis Via Zinc Transporters in Humans with Sepsis." Presented at Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine 3rd Annual Research Day, . (January 2008)

"Ventilation / Perfusion Physiology." Presented at Pulmonary Medical School Lecture Series, . (January 2008)

"TB Pleurisy." Presented at Pulmonary Critical Care Fellowship Case Conference, . (January 2008)

"Sleep and Obstructive Lung Disease." Presented at Sleep Fellowship Didactic Lecture Series, . (January 2008)

"Sleep Actigraphy." Presented at Sleep Fellowship Didactic Lecture Series, . (January 2008)

"Radiology Survival Skills." Presented at APN CME Lecture Series, . (January 2008)

"Hemoptysis." Presented at Internal Medicine Residency Lecture Series, . (January 2008)

"Smokin’ ICE: Cigarette Smoke Extract Suppresses Inflammasome In Peripheral Blood Monocytes Production." Presented at Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine 3rd Annual Research Day 2008, . (January 2008)

"Inflammasome mRNA Expression in Critically Ill Patients." Presented at American Thoracic Society International Meeting, . (January 2008)

"Clinical Characteristics of In-Hospital Cardiac Arrest Patients Surviving to Hospital Discharge." Presented at Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine 3rd Annual Research Day, . (January 2008)

"Modulation of Zinc Homeostasis Via Zinc Transporters in Humans with Sepsis.." Presented at American Thoracic Society International Meeting, . (May 2008)

"Updates in Sepsis. The Surviving Sepsis Campaign 2008 Guidelines." Presented at Madison County Hospital - Grand Rounds, London, OH. (January 2009)

"Update on Critical Care Medicine." Presented at Medcentral Health System - Grand Rounds, Mansfield, OH. (January 2009)

"Tuberculosis for the Pulmonary Consultant." Presented at Pulmonary Fellowship Didactic Lecture, Columbus, OH. (January 2009)

"The Genetics of Sepsis and the Innate Immune System." Presented at American Thoracic Society International Meeting, San Diego, CA, US|USA. (January 2009)

"Mechanical Ventilation II - Ventilators in ARDS." Presented at Pulmonary Medical School Lecture Series, . (January 2009)

"Mechanical Ventilation." Presented at Fundamentals of Medicine Lecture Series (Intern Lecture Series), . (January 2009)

"Cigarette Smoke Extract Suppresses Innate Immune Response in Peripheral Blood Monocytes." Presented at American Thoracic Society International Meeting, San Diego, CA. (January 2009)

"Inflammasome Constituents Released Via Microvesicles During Sepsis." Presented at American Thoracic Society International Meeting, New Orleans, LA. (January 2010)

"Surviving Sepsis Guidelines – Update." Presented at Multidisciplinary Advances in the Treatment of the Critically Ill Patient (MATCH Conference), Columbus, OH. (January 2010)

"Code Sepsis!." Presented at Current Concepts in Clinical Nursing Practice, . (January 2010)

"What's Going on in Here? Hemodynamic Monitoring in the ICU." Presented at Pulmonary Fellowship Didactic Lecture, . (January 2010)

"Ventilator-Associated Pneumonia: How to Save (with) a Bundle." Presented at OSU Internal Medicine Grand Rounds, Columbus, OH. (January 2010)

"Ventilator Waveforms and Physiology." Presented at Pulmonary Fellowship Didactic Lecture, Columbus, OH. (January 2010)

"Physiology 5 - Ventilation and Perfusion Physiology." Presented at Med II Pulmonary Course, Columbus, OH. (January 2010)

"Noscomial Pneumonia." Presented at Medcentral Health System - Grand Rounds, Mansfield, OH. (January 2010)

"Medical Legal Consultation." Presented at Pulmonary Fellowship Career Conference, Columbus, OH. (January 2010)

"Introduction to Tuberculosis." Presented at Pulmonary Fellowship Didactic Lecture Series, Columbus, OH. (January 2010)

"Diagnosis of Tuberculosis." Presented at Ohio Department of Rehabilitation and Correction, Medical Leadership Quarterly Meeting, London, OH. (January 2010)

"Chest X-ray Refresher Course." Presented at James Nurse Practitioner Noon Conference, Columbus, OH. (January 2010)

"Achieving Adequate Amikacin Levels in a Medical Intensive Care Unit." Presented at Society of Critical Care Medicine’s 39th Critical Care Congress, Miami. (January 2010)

"Pathogen Sensor NLRP3 Suppressed During Sepsis And Improves During Recovery." Presented at American Thoracic Society International Meeting, Denver, CO. (May 2011)

"Serum And Alveolar LL-37 Is Elevated In Respiratory Failure Patients But Not In Septic Patients." Presented at American Thoracic Society International Meeting, Denver, CO. (May 2011)

"Pulmonary Toxicity from Bortezomib Successfully Treated with Steroids in a Patient with Acute Myelogenous Leukemia." Presented at American Thoracic Society International Meeting, . (May 2012)

"NOD1 and NOD2 Message Suppressed in Septic Patient Monocytes." Presented at American Thoracic Society International Meeting, . (May 2012)

"Sepsis Outcomes May Improve In Patients With Improved Plasma Zinc Concentration ICU Day Five." Presented at American Thoracic Society International Meeting, San Francisco, CA. (May 2012)

"Severity of Illness, Not Pathogen Determines Suppression of Pathogen Sensors in Sepsis." Presented at American Thoracic Society International Meeting, San Francisco, CA. (May 2012)

Professional Activities

present

Conference Facilitator - "Sepsis" Thematic Posters. American Thoracic Society. San Francisco, CA.