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Jonathan Butchar, PhD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-6788

Email: butchar.2@osu.edu

 

Current OSU Appointment

Research Assistant Professor, Pulm,Allergy,Crit Care & Sleep

 

Editorial Activities

present Microbes and Infection
present BMC Microbiology
present PLoS ONE
2012 - 2013 BBA - Molecular and Cell Biology of Lipids
 

Journal Articles

Butchar,Jonathan,P; Parsa,Kishore,VL; Marsh,Clay,B; Tridandapani,Susheela. "Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response." CURRENT PHARMACEUTICAL DESIGN. Vol. 12, no. 32. (January 2006.): 4143-4153.

Roda JM; Joshi T; Butchar JP; McAlees JW; Lehman A; Tridandapani S; Carson WE 3rd. "The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokines.." Clinical Cancer Research: An Official Journal Of The American Association For Cancer Research. Vol. 13, no. 21. (November 2007.): 6419-.

Butchar,Jonathan,P; Rajaram,Murugesan,VS; Ganesan,Latha,P; Parsa,Kishore,VL; Clay,Corey,D; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella tularensis induces IL-23 production in human monocytes." JOURNAL OF IMMUNOLOGY. Vol. 178, no. 7. (April 2007.): 4445-4454.

Mehta,Payal; Wavreille,Anne-Sophie; Butchar,Jonathan,P; Tridandapani,Susheela. "Differences in signaling properties of Fc gamma RI and Fc gamma RIIa in human monocytic cells." FASEB JOURNAL. Vol. 22, (April 2008.): -.

Cremer,Thomas,John; Hunter,Melissa,G; Elton,Terry,S; Marsh,Clay,B; Tridandapani,Susheela; Butchar,Jonathan,P. "microRNA influence on host response to Francisella infection." FASEB JOURNAL. Vol. 22, (April 2008.): -.

Butchar,Jonathan,P; Rajaram,Murugesan,VS; Parsa,Kishore,VL; Clay,Corey,D; Gunn,John,S; Schlesinger,Larry,S; Tridandapani,Susheela. "IL-23 aids in defense against Francisella infection." FASEB JOURNAL. Vol. 22, (April 2008.): -.

Butchar,Jonathan,P; Parsa,Kishore,VL; Marsh,Clay,B; Tridandapani,Susheela. "IFN gamma enhances IL-23 production during Francisella infection of human monocytes." FEBS LETTERS. Vol. 582, no. 7. (April 2008.): 1044-1048.

Simcox,Amanda; Mitra,Sayan; Truesdell,Sharon; Paul,Litty; Chen,Ting; Butchar,Jonathan,P; Justiniano,Steven. "Efficient Genetic Method for Establishing Drosophila Cell Lines Unlocks the Potential to Create Lines of Specific Genotypes." PLOS GENETICS. Vol. 4, no. 8. (August 2008.): e1000142-.

Butchar,Jonathan,P; Cremer,Thomas,J; Clay,Corey,D; Gavrilin,Mikhail,A; Wewers,Mark,D; Marsh,Clay,B; Schlesinger,Larry,S; Tridandapani,Susheela. "Microarray Analysis of Human Monocytes Infected with Francisella tularensis Identifies New Targets of Host Response Subversion." PLOS ONE. Vol. 3, no. 8. (August 2008.): e2924-.

Parsa,Kishore,VL; Butchar,Jonathan,P; Rajaram,Murugesan,VS; Cremer,Thomas,J; Tridandapani,Susheela. "The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk." MOLECULAR IMMUNOLOGY. Vol. 45, no. 10. (May 2008.): 3012-3021.

Butchar JP; Cremer TJ; Clay CD; Gavrilin MA; Wewers MD; Marsh CB; Schlesinger LS; Tridandapani S. "Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion.." Plos One. Vol. 3, no. 8. (January 2008.): e2924-.

Cremer TJ; Ravneberg DH; Clay CD; Piper-Hunter MG; Marsh CB; Elton TS; Gunn JS; Amer A; Kanneganti TD; Schlesinger LS; Butchar JP; Tridandapani S. "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response.." Plos One. Vol. 4, no. 12. (January 2009.): e8508-.

Rajaram,Murugesan,VS; Butchar,Jonathan,P; Parsa,Kishore,VL; Cremer,Thomas,J; Amer,Amal; Schlesinger,Larry,S; Tridandapani,Susheela. "Akt and SHIP Modulate Francisella Escape from the Phagosome and Induction of the Fas-Mediated Death Pathway." PLOS ONE. Vol. 4, no. 11. (November 2009.): e7919-.

Cremer TJ; Amer A; Tridandapani S; Butchar JP. "Francisella tularensis regulates autophagy-related host cell signaling pathways.." Autophagy. Vol. 5, no. 1. (January 2009.): 125-.

Awan,Farrukh; Lapalombella,Rosa; Trotta,Rossana; Butchar,Jonathan,P; Yu,Bo; Benson,Don; Cheney,Carolyn; Mo,Xiaokui; Lehman,Amy; Jones,Jeffrey,Alan; Flynn,Joseph,M; Jarjoura,David; Baiocchi,Robert,A; Desjarlais,John; Tridandapani,Susheela; Caligiuri,Michael,A; Muthusamy,Natarajan; Byrd,John,C. "CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody." BLOOD. Vol. 114, no. 22. (November 2009.): 1435-1435.

Butchar,Jonathan,P; Mehta,Payal; Justiniano,Steven,E; Guenterberg,Kristan,D; Kanneganti,Thirumala-Devi; Amer,Amal; Muthusamy,Natarajan; Jarjoura,David; Marsh,Clay,B; Carson,William,E; Byrd,John,C; Tridandapani,Susheela. "TLR7/8 Differentially Regulates Fc gamma Receptor Expression and Function." BLOOD. Vol. 114, no. 22. (November 2009.): 1391-1392.

Lapalombella,R; Yu,B; Triantafillou,G; Liu,Q; Butchar,J,P; Lozanski,G; Ramanunni,A; Smith,L,L; Blum,W; Andritsos,L; Wang,D,S; Lehman,A; Chen,C,S; Johnson,A,J; Marcucci,G; Lee,R,J; Lee,L,J; Tridandapani,S; Muthusamy,N; Byrd,J,C. "Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells (vol 112, pg 5180, 2008)." BLOOD. Vol. 114, no. 16. (October 2009.): 3506-3506.

Cremer,Thomas,J; Amer,Amal; Tridandapani,Susheela; Butchar,Jonathan,P. "Francisella tularensis regulates autophagy-related host cell signaling pathways." AUTOPHAGY. Vol. 5, no. 1. (January 2009.): 125-128.

Butchar,Jonathan,P; Mehta,Payal; Justiniano,Steven,E; Guenterberg,Kristan,D; Kondadasula,Sri-Vidya; Mo,Xiaokui; Chemudupati,Mahesh; Kanneganti,Thirumala-Devi; Amer,Amal; Muthusamy,Natarajan; Jarjoura,David; Marsh,Clay,B; Carson,William,E; Byrd,John,C; Tridandapani,Susheela. "Reciprocal Regulation of Activating and Inhibitory Fc gamma Receptors by TLR7/8 Activation: Implications for Tumor Immunotherapy." CLINICAL CANCER RESEARCH. Vol. 16, no. 7. (April 2010.): 2065-2075.

Butchar JP; Mehta P; Justiniano SE; Guenterberg KD; Kondadasula SV; Mo X; Chemudupati M; Kanneganti TD; Amer A; Muthusamy N; Jarjoura D; Marsh CB; Carson WE 3rd; Byrd JC; Tridandapani S. "Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy.." Clinical Cancer Research: An Official Journal Of The American Association For Cancer Research. Vol. 16, no. 7. (April 2010.): 2065-.

Jonathan P. Butchar, John C. Byrd. "Targeting CD20: Still much more to learn." The Hematologist. (October 2010.): -.

Thomas J. Cremer, Prexy Shah, Estelle Cormet-Boyaka, Miguel A. Valvano, Jonathan P.Butchar and Susheela Tridandapani. "Akt-mediated pro-inflammatory response of mononuclear phagocytes infectedwith Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IKK-independentmechanism." Journal of Immunology. (January 2011.): -.

Payal Mehta;Anne-Sophie Wavreille;Steven E Justiniano;Rachel L Marsh;JianhuaYu;Richard Burry;David Jarjoura;Timothy Eubank;Michael A Caligiuri;Jonathan P Butchar;SusheelaTridandapani. "LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis." PLoS ONE. (January 2011.): -.

Cremer,Thomas,J; Shah,Prexy; Cormet-Boyaka,Estelle; Valvano,Miguel,A; Butchar,Jonathan,P; Tridandapani,Susheela. "Akt-Mediated Proinflammatory Response of Mononuclear Phagocytes Infected with Burkholderia cenocepacia Occurs by a Novel GSK3 beta-Dependent, I kappa B Kinase-Independent Mechanism." JOURNAL OF IMMUNOLOGY. Vol. 187, no. 2. (July 2011.): 635-643.

Cremer,Thomas,John; Butchar,Jonathan,P; Tridandapani,Susheela. "Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt.." Frontiers in microbiology. Vol. 5, (January 2011.): 13-?.

Rafiq,Sarwish; Butchar,Jonathan,P; Cheney,Carolyn; Mo,Xiaokui; Jarjoura,David; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties." BLOOD. Vol. 118, no. 21. (November 2011.): 1588-1588.

Mehta,Payal; Wavreille,Anne-Sophie; Justiniano,Steven,E; Marsh,Rachel,L; Yu,Jianhua; Burry,Richard,W; Jarjoura,David; Eubank,Timothy; Caligiuri,Michael,A; Butchar,Jonathan,P; Tridandapani,Susheela. "LyGDI, a Novel SHIP-Interacting Protein, Is a Negative Regulator of Fc gamma R-Mediated Phagocytosis." PLOS ONE. Vol. 6, no. 6. (June 2011.): e21175-.

Yu J, Mitsui T, Wei M, Mao H, Butchar JP, Shah MV, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G Jr, Benson DM, Loughran TP Jr, Tridandapani S, Caligiuri MA.. "NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.." Journal of Clinical Investigation. Vol. 121, no. 4. (April 2011.): 1456-1470.

Cremer,Thomas,J; Fatehchand,Kavin; Shah,Prexy; Gillette,Devyn; Patel,Hemal; Marsh,Rachel,L; Besecker,Beth,Y; Rajaram,Murugesan,VS; Cormet-Boyaka,Estelle; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "MiR-155 induction by microbes/microbial ligands requires NF-?B-dependent de novo protein synthesis.." Frontiers in cellular and infection microbiology. Vol. 2, (January 2012.): 73-?.

Butchar,Jonathan,P; Shah,Prexy; Patel,Hemal; Fatehchand,Kavin; Rafiq,Sarwish; Cheney,Carolyn; Vasilakos,John,P; Muthusamy,Natarajan; Byrd,John,C; Tridandapani,Susheela. "TLR7/8 Agonists Overcome the Suppression of Fc gamma R Activity in Monocytes From Chronic Lymphocytic Leukemia Patients." BLOOD. Vol. 120, no. 21. (November 2012.): -.

Butchar,Jonathan,P; Cain,Donna; Manivannan,Sathiya,N; McCue,Andrea,D; Bonanno,Liana; Halula,Sarah; Truesdell,Sharon; Austin,Christina,L; Jacobsen,Thomas,L; Simcox,Amanda. "New Negative Feedback Regulators of Egfr Signaling in Drosophila." GENETICS. Vol. 191, no. 4. (August 2012.): 1213-U260.

Shah,Prexy; Justiniano,Steven; Dunn,Robert; Jarjoura,David; Byrd,John; Butchar,Jon; Tridandapani,Susheela. "Toll-like receptor 2 ligands enhance monocyte Fc gamma receptor function." JOURNAL OF IMMUNOLOGY. Vol. 188, (May 2012.): -.

Gillette,Devyn,D; Shah,Prexy,A; Cremer,Thomas; Gavrilin,Mikhail,A; Besecker,Beth,Y; Sarkar,Anasuya; Knoell,Daren,L; Cormet-Boyaka,Estelle; Wewers,Mark,D; Butchar,Jonathan,P; Tridandapani,Susheela. "Analysis of Human Bronchial Epithelial Cell Proinflammatory Response to Burkholderia cenocepacia Infection INABILITY TO SECRETE IL-1 beta." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 288, no. 6. (February 2013.): 3691-3695.

Shah,Prexy; Fatehchand,Kavin; Patel,Hemal; Fang,Huiqing; Justiniano,Steven,E; Mo,Xiaokui; Jarjoura,David; Tridandapani,Susheela; Butchar,Jonathan,P. "Toll-like Receptor 2 Ligands Regulate Monocyte Fc gamma Receptor Expression and Function." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 288, no. 17. (April 2013.): 12345-12352.

 

Professional Activities

2006 - present Pulmonary Division Research Day. Pulmonary Division, OSUMC.
2006 - present Pulmonary Division research seminar series. Pulmonary Division, OSUMC.
2007 - present CMIB Research Retreat. Center for Microbial Interface Biology, OSU.
2007 - present Research Seminar Series. Pulmonary Division, OSUMC.
2007 - present Research Retreat. DHLRI.
2007 - present Resarch Day. OSUMC.
2007 - present Innate Immunity Seminar Series. OSU Comprehensive Cancer Center.
2007 - present Annual Conference. OSU Comprehensive Cancer Center.
2007 - present Research Day. Pulmonary Division, OSUMC.
2007 - present 4th Annual Meeting. Regional Center of Excellence. St. Louis, MO.
2008 - present Research Day. PACCS, OSUMC.
2008 - present Research Retreat. DHLRI.
2008 - present 95th Annual Meeting. American Association of Immunologists.
2008 - present Annual Meeting. OSU Comprehensive Cancer Center.
2008 - present CMIB Research Retreat. OSU Center for Microbial Interface Biology.
2009 - present Research Day. PACCS, OSUMC.
2009 - present Research Retreat. DHLRI, OSUMC.
2009 - present 51st Annual Meeting. American Society of Hematology.
2010 - present Research Seminar Series. PACCS, OSUMC.
2010 - present Annual Meeting. OSU Comprehensive Cancer Center.
2006 5th International Conference on Tularemia. Woods Hole, MA.
2007 Annual Meeting. Great Lakes Regional Center of Excellence. Hilton Head, SC.