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Elliott D. Crouser, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: crouser.1@osu.edu

 

Current OSU Appointments

Associate Professor, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

 

Biographical

In addition to running the Sarcoidosis Clinic at OSU, Dr. Crouser is the Section Chief for the Division of Pulmonary and Critical Care Medicine and Medical Director of the ICU at University Hospital East (an affiliate of The Ohio State University Medical Center in Columbus, OH). Under his leadership the ICU structure has been optimized to deliver outstanding care (below target length-of-stay; risk adjusted mortality consistently <0.5) while providing expanded services (e.g., new stroke and acute myocardial infarction initiatives, increasing census). He also serves as an Editor for Critical Care Medicine, the top-ranked journal specializing in critical care, and reviews or serves on editorial boards for more than 20 other journals. He has served on NIH study sections, including an ongoing temporary appointment to the Surgery Anesthesia and Trauma study section (for 3 consecutive cycles), and has also reviewed grants for the Society of Critical Care Medicine, Wellcome Trust (London) and other extramural funding agencies. Dr. Crouser is actively funded by extramural sources for over 15 years, including ongoing support from the NIH to investigate inflammatory diseases that involve the lungs and other organs in the context of acute and chronic illness. His laboratory is among the first to have identified mitochondria as critical mediators of cell and organ dysfunction in the setting of acute systemic inflammatory diseases, including sepsis. His genomic studies in the field of pulmonary sarcoidosis identified novel disease mechanisms and "biomarkers" of disease progression. Ongoing studies in these areas of research promise to provide targets for new treatments for these poorly understood diseases.

Certifications

1992 - present Board Certification: American Board of Internal Medicine
1994 - present Board Certification: American Board of Internal Medicine
1995 - present Medical License: State Medical Board of Ohio
1995 - present Board Certification: American Board of Internal Medicine
2004 - present Board Re-Certification: American Board of Internal Medicine
2004 - present Board Re-Certification: American Board of Internal Medicine
 

Chapters in Books

Crouser ED, St. John RC. "Clinical assessment of tissue oxygenation." In Seminars in Respiratory and Critical Care Medicine: Oxygen Consumption and Transport in the Critically Ill.. Edited by Dorinsky PM. 382-93. New York, NY: Thieme Medical Publishers, Inc, January 1995.

Crouser ED, Fahy RJ. "Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome." In Egan’s Fundamentals of Respiratory Care, Eighth Edition. Edited by Scanlon C, Wilkins and Stoller J. -. St. Louis, MO: Mosby-Year Book, Inc., January 2002.

Crouser ED, Dorinsky PM. "Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome." In Egan’s Fundamentals of Respiratory Care, Seventh Edition. Edited by Scanlon C, Wilkins and Stoller J. -. St. Louis, MO: Mosby-Year Book, Inc., January 2003.

Fahy RJ, Crouser ED. "Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome." In Egan’s Fundamentals of Respiratory Care, Ninth Edition. -. St. Louis, MO: Mosby-Year Book, Inc., January 2006.

 

Degrees

1983 B.A., Oberlin College

1989 M.D., Medical College of Ohio

 

Editorial Activities

present Biochimica et Biophysica Acta
 

Journal Articles

Hulman, S; Kliegman, R; Heng, J; Crouser E. "Relationship of substrate level to turnover rate in fasted adult and newborn dogs.." The American journal of physiology. Vol. 254, no. 2 Pt 1. (January 1988.): E137-43.

Crouser E; Dorinsky, P M. "Gastrointestinal tract dysfunction in critical illness: pathophysiology and interaction with acute lung injury in adult respiratory distress syndrome/multiple organ dysfunction syndrome.." New horizons (Baltimore, Md.). Vol. 2, no. 4. (January 1994.): 476-87.

Crouser E; Julian, M, W; Weisbrode, S, E; Dorinsky, P M. "Acid aspiration results in ileal injury without altering ileal V(O2)-D(O2) relationships.." American journal of respiratory and critical care medicine. Vol. 153, no. 6 Pt 1. (January 1996.): 1965-71.

Crouser E; Dorinsky, P M. "Metabolic consequences of sepsis. Correlation with altered intracellular calcium homeostasis.." Clinics in chest medicine. Vol. 17, no. 2. (January 1996.): 249-61.

Dorinsky PM, Crouser ED. "Oxygen Delivery in Critically Ill Patients." Mediguide. no. Mediguide 4: 1-5. (January 1997.): -.

Crouser E; Julian, M, W; Weisbrode, S, E; Dorinsky, P M. "Ischemia/reperfusion injury to the ileum does not account for the ileal VO2-DO2 alterations induced by endotoxin.." Journal of critical care. Vol. 12, no. 4. (January 1997.): 200-7.

Crouser E; Julian, M, W; Weisbrode, S, E; Dorinsky, P M. "Endotoxin-induced ileal Vo2-Do2 alterations do not correlate with the severity of ileal injury.." Journal of critical care. Vol. 12, no. 2. (January 1997.): 83-91.

Crouser E; Julian, M, W; Dorinsky, P M. "Ileal VO(2)-O(2) alterations induced by endotoxin correlate with severity of mitochondrial injury.." American journal of respiratory and critical care medicine. Vol. 160, no. 4. (January 1999.): 1347-53.

Joshi, M, S; Crouser E; Julian, M, W; Schanbacher, B, L; Bauer, J A. "Digital imaging analysis for the study of endotoxin-induced mitochondrial ultrastructure injury.." Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. Vol. 21, no. 1. (January 2000.): 41-8.

Fahy, R, J; Crouser E; Pacht, E R. "Herpes simplex type 2 causing fulminant hepatic failure.." Southern medical journal. Vol. 93, no. 12. (January 2000.): 1212-6.

Crouser E; Julian, M, W; Weinstein, D, M; Fahy, R, J; Bauer, J A. "Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated.." American journal of respiratory and critical care medicine. Vol. 161, no. 5. (January 2000.): 1705-12.

Weil MH, Becker L, Kern K, Nichol G, Shechter I, Traystman R, Wiedemann H, Wise R, Weisfeldt M, Sopko G and participants in the "PULSE workshop" (including Crouser E). "Workshop Summary Report: Post-Resuscitative and Initial Utility in Life Saving Efforts (PULSE)." Circulation. no. 103. (January 2001.): 1182-1184.

Crouser, Elliott D; Julian, Mark, W; Joshi, Mandar, S; Bauer, John, A; Wewers, Mark, D; Hart, Judith, M; Pfeiffer, Douglas R. "Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia.." Critical care medicine. Vol. 30, no. 12. (January 2002.): 2722-8.

Crouser ED; Julian, Mark, W; Blaho, Dorottya, V; Pfeiffer, Douglas R. "Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity.." Critical care medicine. Vol. 30, no. 2. (January 2002.): 276-84.

Backer LB, Weisfeldt ML, Weil MH, Budinger T, Carico J, Kern K, Nichol G, Shechter I, Traystman R, Webb C, Wiedemann H, Sopko G, and participants in the "PULSE Workshop" (including Crouser E). "The PULSE Initiative: Scientific Priorities and Strategic Planning for Resuscitation Research and Life Saving Therapies." Circulation. no. 105. (January 2002.): 2562-2570.

Broekemeier, Kimberly, M; Iben, James, R; LeVan, Emily, G; Crouser; Pfeiffer, Douglas R. "Pore formation and uncoupling initiate a Ca2+-independent degradation of mitochondrial phospholipids.." Biochemistry. Vol. 41, no. 24. (January 2002.): 7771-80.

Crouser ED; Julian, Mark, W; Huff, Jennifer, E; Broekemeier, Kimberly, M; Robbins, Karen, A; Pfeiffer, Douglas R. "Quantitation of cytochrome c release from rat liver mitochondria.." Analytical biochemistry. Vol. 317, no. 1. (January 2003.): 67-75.

Lucarelli, Maria, R; Shirk, Mary Beth; Julian, Mark, W; Crouser, Elliott D. "Toxicity of Food Drug and Cosmetic Blue No. 1 dye in critically ill patients.." Chest. Vol. 125, no. 2. (January 2004.): 793-5.

Crouser ED. "Therapeutic benefits of antioxidants during sepsis: is protection against oxidant-mediated tissue damage only half the story?." Critical Care Medicine. Vol. 32, no. 2. (February 2004.): 589-.

Crouser ED; Huff, Jennifer, E; Joshi, Mandar, S; Bauer, John, A; Gadd, Martha, E; Wewers, Mark, D; Pfeiffer, Douglas R. "Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia.." Critical care medicine. Vol. 32, no. 2. (January 2004.): 478-88.

Crouser ED. "Mitochondrial Dysfunction in Septic Shock and Multiple Organ Dysfunction Syndrome." Mitochondrion. Vol. 4, (January 2004.): 729-741.

Crouser E, Cook C, Julian M, Huff J. "Impaired mitochondrial function and structure in the liver during subacute sepsis." Proceedings of the 6th World Congress on Trauma, Shock, Inflammation and Sepsis. (January 2004.): 199-201.

Crouser ED. "Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome.." Mitochondrion. Vol. 4, no. 5-6. (September 2004.): 729-.

Crouser, Elliott D. "Redefining the roles of apoptosis pathways during sepsis.." Critical care medicine. Vol. 33, no. 3. (January 2005.): 670-2.

Crouser E. "Is cell death a prerequisite for cardiac dysfunction during sepsis?." Critical care medicine. Vol. 33, no. 5. (January 2005.): 1160-2.

Crouser, Elliott D. "Respiratory failure during critical illness: are mitochondria to blame?." American journal of respiratory and critical care medicine. Vol. 172, no. 7. (January 2005.): 793-4.

Fahy RJ, Crouser ED. "Summary of International Conference of the American Thoracic Sociey." Advances in Sepsis. Vol. 4, (January 2005.): 154-156.

Crouser, Elliott, D; Julian, Mark, W; Huff, Jennifer, E; Struck, Joachim; Cook, Charles H. "Carbamoyl phosphate synthase-1: a marker of mitochondrial damage and depletion in the liver during sepsis.." Critical care medicine. Vol. 34, no. 9. (January 2006.): 2439-46.

Crouser, Elliott, D; Julian, Mark, W; Huff, Jennifer, E; Mandich, David, V; Green-Church, Kari B. "A proteomic analysis of liver mitochondria during acute endotoxemia.." Intensive care medicine. Vol. 32, no. 8. (January 2006.): 1252-62.

O'Brien JM, Crouser ED. "35th Critical Care Congress of the Society of Critical Care Medicine." Advances in Sepsis. Vol. 5, (January 2006.): 120-122.

Gadd, Martha, E; Broekemeier, Kimberly, M; Crouser, Elliott, D; Kumar, Jitendra; Graff, Gustav; Pfeiffer, Douglas R. "Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition.." The Journal of biological chemistry. Vol. 281, no. 11. (January 2006.): 6931-9.

Joshi, Mandar, S; Julian, Mark, W; Huff, Jennifer, E; Bauer, John, A; Xia, Yong; Crouser, Elliott, D. "Calcineurin regulates myocardial function during acute endotoxemia.." American journal of respiratory and critical care medicine. Vol. 173, no. 9. (January 2006.): 999-1007.

Wynbrandt, Jonathan, H; Crouser, Elliot D. "Transformation of pulmonary histoplasmosis to sarcoidosis: a case report.." Respiratory medicine. Vol. 101, no. 4. (January 2007.): 863-4.

Ezzie,Michael,E; Crouser,Elliott,D. "Considering an infectious etiology of sarcoidosis." CLINICS IN DERMATOLOGY. Vol. 25, no. 3. (May 2007.): 259-266.

Crouser ED. "Suppression of monocyte metabolism by septic plasma: revisiting the concept of "blood poisoning".." Critical Care Medicine. Vol. 35, (January 2007.): 2856-2857.

Hoffmann S, Crouser ED. "Mitochondrial Mechanisms if Organ Dysfunction During Sepsis." Advances in Sepsisq. Vol. 6, (January 2007.): 2-9.

Hussain SRA, Lucas DM, Johnson AJ, Lin TS, Bakaletz AP, Viatchenko-Karpinski S, Dang VX, Kuppusamy P, Crouser E, Byrd JC, Grever MR. "Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium." Blood. no. 111. (January 2008.): 3190-3199.

Crouser ED, Exline M, Knoell D, Wewers MD. "Sepsis: links between pathogen sensing and organ damage." Current Pharmaceutical Design. Vol. 14, (January 2008.): 1840-1852.

Belknap JK, Moore JN, Crouser ED. "Sepsis- From Organ Failure to Laminar Failure." Veterinary Immunology and Immunopathology. no. EPub prior to print 11/11/08. (November 2008.): -.

Exline MC, Crouser ED. "Mitochondrial mechanisms of sepsis-induced organ failure." Frontiers in Bioscience. Vol. 13, (January 2008.): 5030-5041.

Ali NA, O'Brien JM, Hoffmann SP, Phillips G, Garland A, Findley JC, Almoosa K, Hejal R, Wolf KM, Lemeshow S, Connors AF, Marsh CB. "Acquired weakness, handgrip strength, and mortality in critically ill patients." American Journal of Respiratory and Critical Care Medicine. Vol. 178, (August 2008.): 261-268.

Knoell DL, Julian MW, Bao S, Besecker B, Huff JE, Leikauf G, DiSilvestro R, Crouser E. "Mortaligy is Significantly Increased by Zinc Deficiency in an Adult Murine Model of Polymicrobial Sepsis." Critical Care Medicine. no. 37. (January 2009.): 1380-1388.

Crouser E, Culver DA, Huff JE, Julian MW, Shao G, Liyanarachchi S, Knox KS, Macre JE, Wewers MD, Gavrilin M, Ross P, Abbas A, Eng C. "Gene Expression Profiling Identifies MMP-12 and ADAMDEC1 as Potential Pathogenic Mediators of Pulmonary Sarcoidosis." Am J Respir Critical Care Medicine. no. 179. (January 2009.): 929-938.

Crouser,Elliott,D; Shao,Guohong; Julian,Mark,W; Macre,Jennifer,E; Shadel,Gerald,S; Tridandapani,Susheela; Huang,Qin; Wewers,Mark,D. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." CRITICAL CARE MEDICINE. Vol. 37, no. 6. (June 2009.): 2000-2009.

Rosenbaum JT, Pasadhika S, Crouser E, Harrington CA, Choi D, Smith JR, Braziel RM, Vance EE, Planck SR. "Hypothesis: Sarcoidosis is a STAT1-mediated disease." Clinical Immunology. no. 132. (January 2009.): 174-183.

Pompili VJ; Crouser ED. "Stem cell therapy: A "magic bullet" for cardiomyopathies?." Critical Care Medicine. Vol. 37, no. 4. (April 2009.): 1487-.

Crouser E, Lozanski G, Fox CC, Hauswirth DW, Raveendran R, Julian MW. "The CD4+lymphopeni sarcoidosis phenotype is highly responsive to anti-TNF therap." Chest. no. 137. (January 2010.): 1432-1435.

Crouser ED. "Peroxisome proliferator-activated receptors gamma coactivator-1alpha: master regulator of mitochondrial biogenesis and survival during critical illness?." American Journal Of Respiratory And Critical Care Medicine. Vol. 182, no. 6. (September 2010.): 726-.

Nana-Sinkam SP; Crouser ED. "Altered immune surveillance: a common link between cancer and sepsis?." Critical Care Medicine. Vol. 38, no. 3. (March 2010.): 1000-.

Shao,Guohong; Julian,Mark,W; Bao,Shengying; McCullers,Meghan,K; Lai,Ju-Ping; Knoell,Daren,L; Crouser,Elliott,D. "Formyl Peptide Receptor Ligands Promote Wound Closure in Lung Epithelial Cells." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 44, no. 3. (March 2011.): 264-269.

Julian,Mark,W; Bao,Shengying; Knoell,Daren,L; Fahy,Ruairi,J; Shao,Guohong; Crouser,Elliott,D. "Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis." INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. Vol. 92, no. 5. (October 2011.): 366-376.

Crouser,Elliott,D; Parinandi,Narasimham. "Mitochondrial mechanisms are at the 'heart' of novel ischemia-reperfusion therapies." CRITICAL CARE MEDICINE. Vol. 39, no. 3. (March 2011.): 593-595.

Exline,Matthew,C; Crouser,Elliott,D. "Mitochondrial dysfunction during sepsis: Still more questions than answers." CRITICAL CARE MEDICINE. Vol. 39, no. 5. (May 2011.): 1216-1217.

Erdal,Barbaros,Selnur; Crouser,Elliott,D; Yildiz,Vedat; King,Mark,A; Patterson,Andrew,T; Knopp,Michael,V; Clymer,Bradley,D. "Quantitative Computerized Two-Point Correlation Analysis of Lung CT Scans Correlates With Pulmonary Function in Pulmonary Sarcoidosis." CHEST. Vol. 142, no. 6. (December 2012.): 1589-1597.

Julian,Mark,W; Shao,Guohong; Bao,Shengying; Knoell,Daren,L; Papenfuss,Tracey,L; Vangundy,Zachary,C; Crouser,Elliott,D. "Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 1. (July 2012.): 433-443.

Erdal,Barbaros,S; Clymer,Bradley,D; Yildiz,Vedat,O; Julian,Mark,W; Crouser,Elliott,D. "Unexpectedly high prevalence of sarcoidosis in a representative US Metropolitan population." RESPIRATORY MEDICINE. Vol. 106, no. 6. (June 2012.): 893-899.

Crouser,Elliott,D. "Warming up to hypothermia for treatment of severe sepsis." CRITICAL CARE MEDICINE. Vol. 40, no. 3. (March 2012.): 1020-1022.

Julian,Mark,W; Shao,Guohong; Schlesinger,Larry,S; Huang,Qin; Cosmar,David,G; Bhatt,Nitin,Y; Culver,Daniel,A; Baughman,Robert,P; Wood,Karen,L; Crouser,Elliott,D. "Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis." CHEST. Vol. 143, no. 2. (February 2013.): 461-470.

Julian,Mark,W; Shao,Guohong; Vangundy,Zachary,C; Papenfuss,Tracey,L; Crouser,Elliott,D. "Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNF alpha Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells." PLOS ONE. Vol. 8, no. 8. (August 2013.): .-.

Chang,Henry; Tam Tran,T; Billman,George,E; Julian,Mark,W; Hamlin,Robert,L; Simonetti,Orlando,P; Ambrosio,Giuseppe; Baker,Peter,B; Shao,Guohong; Crouser,Elliott,D; Raman,Subha,V. "At-risk but viable myocardium in a large animal model of non ST-segment elevation acute coronary syndrome: cardiovascular magnetic resonance with ex vivo validation." JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE. Vol. 15, (October 2013.): 94-.

 

Reference Works

January 2006 Lucas, D. M.; Hussain, S. R. A.; Johnson, A. J.; Smith, L. L.; Wagner, A. J.; Allison, J. M.; Guster, S. E.; Lin, T. S.; Byrd, J. C.; Julian, M. W.; Crouser, E. D.; Grever, M. R.."Flavopiridol decreases Mcl-1 and initiates early mitochondrial damage in chronic lymphocytic leukemia (CLL) cells" . : 595A
January 2007 Shao, G.; Julian, M. W.; Huff, J. E.; Wewers, M. D.; Shadel, G. S.; Crouser, E. D.."Highly purified high mobility group proteins do not directly activate peripheral blood monocytes" . : A447
January 2007 Crouser, E. D.; Huff, J. E.; Wewers, M. D.; Knox, K. S.; Ross, P.; Abbas, A.; Eng, C.."Analysis of lung gene expression in sarcoidosis and granulomatous infections" . : A185
January 2007 Knoell, D. L.; Julian, M. W.; Bao, S.; Huff, J. E.; Crouser, E. D.."Sepsis mortality is dramatically increased in zinc deficient mice" . : A437
January 2008 Pasadhika, S.; Crouser, E. D.; Harrington, C. A.; Choi, D.; Planck, S. R.; Smith, J. R.; Rosenbaum, J. T.."Microarray gene expression profile of peripheral blood from patients with Sarcoidosis implicates the transcription factor, STAT1" .
November 2008 Raveendran, R.; Hauswirth, D. W.; Crouser, E. D.; Fox, C. C.."Sarcoidosis patients with profound CD4 lymphopenia and opportunistic infections" Seattle.
November 2009 Erdal, S.; Clymer, B.; Crouser, E. D.."Developing CAD tools for measuring sarcoidosis: Leveraging existing data from a personalized health care perspective" Chicago.
November 2009 Erdal, S.; Catalyurek, U.; Krishnamurthy, A.; Kamal, J.; Crouser, E. D.; Clymer, B.."3D haralick texture analysis using CUDA" Chicago.
May 2009 Crouser, E. D.; Julian, M. W.; Shao, G.; Fox, C. C.; Hauswirth, D. W.; Jehn, J. J.; Lozanski, G.; Erdal, S.; Wewers, M. D.."Infliximab reverses peripheral CD4+ T cell depletion in lymphopenic Sarcoidosis patients" San Diego.
May 2010 Thacker, M.; Aguda, B.; Crouser, E. D.."In silico modeling of sarcoidosis granuloma formation implicates TNF alpha and regulatory T cells (Tregs) as critical therapeutic targets" New Orleans.
May 2010 Crouser, E. D.; Shao, G.; Julian, M. W.; Bao, S.."PI-3K is essential for plasmacytoid dendritic cell type I IFN responses to mitochondrial transcription factor A (TFAM) and CpG DNA" San Diego.
May 2010 Crouser, E. D.; Julian, M. W.; Shao, G.."Mitochondrial antigens are selectively recognized by TLR-2 in the context of cell necrosis" New Orleans.
April 2011 Shao G, Julian MW, Boa S, McCullers, Lai JP, MK, Knoell D, Crouser ED."Mitochondrial Protiens Promote Lung Epithelial Wound Closure via Formyl Peptide Receptors" ..
April 2011 Julian MW, Shao G, Bao S, Crouser ED."PI-3K is Essential for Plasmacytoid Dendtritic Cell Type I IFN Responses to Mitochondrial Danger Signals: Mitochondrial Transcription Factor A (TFAM) and CpG DNA" ..

Presentations

"Acid lung injury results in ileal endothelial injury, but not an abnormal VO2-DO2 relationship in the ileum." Presented at American Thoracic Society Meeting, San Francisco, CA. (May 1995)

"Oxygen Metabolism During Sepsis and The Multiple Organ Dysfunction Syndrome." Presented at The Cleveland Clinic Foundation, Cleveland, OH. (March 1995)

"Case Discusant." Presented at Pulmonary Grand Rounds, Columbus, OH. (February 1996)

"Update on Pulmonary Sarcoidosis." Presented at American Lung Association, Ohio Chapter, Columbus, OH. (April 1998)

"Current Views on Pulmonary Sarcoidosis." Presented at Sponsored CME Course, Columbus, OH. (February 1999)

"Update on Pulmonary Sarcoidosis." Presented at American Lung Association, Ohio Chapter, Columbus, OH. (April 1999)

"Advances in Ventilator Management: Strategies for Management of Acute Hypercapneic Respiratory Failure." Presented at Sponsored CME Course, Columbus, OH. (February 1999)

"Induction of the permeability transition contributes to mitochondrial injury and altered respiration during endotoxemia." Presented at Frontiers of Mitochondrial Research Conference, Albany, NY. (September 2000)

"Mitochondria in Acute and Chronic Disease." Presented at Internal Medicine Grand Rounds, Columbus, OH. (January 2000)

"Monitoring Tissue Oxygenation and Other Bioenergetic Parameters During Cardiopulmonary Resuscitation." Presented at Post-Resuscitative and Initial Utility in Life Saving Efforts (PULSE) Workshop, Leesburg, VA. (June 2000)

"Sarcoidosis Update." Presented at The Ohio Thoracic Society, Columbus, OH. (February 2001)

"Advances in the Understanding and Management of Sarcoidosis." Presented at Sponsored CME Course, Columbus, OH. (February 2001)

"Acute Mitochondrial Toxicity During Sepsis (Invited Speaker)." Presented at The Heart & Lung Research Institute, Columbus, OH. (July 2001)

"Mitochondrial membrane damage during acute endotoxemia." Presented at Research in Progress, Columbus, OH. (March 2001)

"Sepsis-induced Organ Failure: The Role of the Mitochondrial Permeability Transition." Presented at Mitochondrial Interest Group (MIG) Teleconference, Columbus, OH. (March 2001)

"Inhibition of the permeability transition attenuates mitochondrial injury and normalizes mitochondrial respiration during endotoxemia." Presented at Mitochondrial Medicine Society Meeting, San Diego, CA. (March 2001)

"New developments in the treatment of sepsis." Presented at Sponsored CME Course, Columbus, OH. (February 2002)

"Mitochondrial dysfunction: Role in Chronic and Acute Disease." Presented at Research in Progress, Columbus, OH. (June 2002)

"Damage and depletion of mitochondria in the liver during CLP sepsis." Presented at 6th World Congress in Trauma, Shock, Inflammation and Sepsis, Munich, DE|DEU. (March 2004)

"Consequences of the Mitochondrial Permeability Transition in Vital Organs During Acute Sepsis." Presented at 6th World Congress in Trauma, Shock, Inflammation and Sepsis, Munich, DE|DEU. (March 2004)

"Advances in the Management of Sepsis." Presented at Sponsored CME Course, Columbus, OH. (February 2004)

"Inflammation and Organ Failure:The Multifaceted Role of Mitochondria." Presented at Ohio State University, . (July 2004)

"Mechanisms of organ failure during sepsis." Presented at Ohio Thoracic Society Annual Meeting, Cambridge, OH. (September 2004)

"Advances in Sepsis." Presented at Sponsored CME Course, Columbus, OH. (February 2005)

"Resonance Between Inflammation and Organ Injury During Sepsis." Presented at Indiana University Pulmonary Grand Rounds, Bloomington, IN. (October 2005)

"Genetically determined susceptibility to retained infectious agents in sarcoidosis patients”. (Invited speaker)." Presented at 3rd Annual National Academies Keck Futures Initiative Conference, Irvine, CA. (November 2005)

"Resonance between organ injury and inflammation during severe sepsis." Presented at American Thoracic Society Meeting, San Diego, CA. (May 2005)

"The susceptibility to mitochondrial damage differs in vital organs during sepsis." Presented at European Shock Society Meeting, Vienna, AT|AUT. (January 2005)

"Gauging Sarcoidosis Disease Activity." Presented at The Cleveland Clinic Foundation, Cleveland, OH. (August 2005)

"Mitochondrial Myths in the Context of Sepsis." Presented at Research In Progress, Columbus, OH. (March 2006)

"Implications of Mitochondrial Damage During Sepsis." Presented at Dorothy M. Davis Heart and Lung Research Retreat, Columbus, OH. (April 2006)

"Diagnosis and Management of Sarcoidosis." Presented at College of Medicine: Medical Therapeutics 664 Course, . (April 2006)

"CPS-1 is a marker of mitochondrial depletion in the liver during sepsis." Presented at Research Day, . (April 2006)

"Sarcoidosis: Diagnosis and Treatment." Presented at Sporsored CME Course, Columbus, OH. (February 2006)

"Apoptosis and Mitochondrial Permeability Transition Pores." Presented at 35th Critical Care Congress, San Francisco, CA. (January 2006)

"Sarcoidosis: What We Know in 2006." Presented at Sarcoidosis Support Group of Columbus, Columbus, OH. (September 2006)

"Diagnosis and Management of Sarcoidosis." Presented at CME Approved Lecture at Children’s Hospital, Columbus, OH. (April 2006)

"Sepsis and MODS: The Human Perspective." Presented at Havenmeyer Equine Conference, Myrtle Beach, South Carolina. (May 2007)

"Pathogenesis of Sepsis-Induced Organ Failures." Presented at Havenmeyer Equine Conference, Myrtle Beach, South Carolina. (May 2007)

"Pathogenesis of Organ Failure During Sepsis: A Case for Mitochondrial Mechanisms." Presented at Cellege of Pharmacy, . (April 2007)

"Mitochondrial N-formyl proteins are primarily responsible for inlammatory responses to necrotic cells." Presented at Dorothy M. Davis Heart & Lung Research Institute, . (April 2007)

"Diagnosis and Management of Sarcoidosis." Presented at College of Medicine: Medical Therapeutics 664 Course, . (April 2007)

"Induction of Inflammation by Mitochondrial Proteins." Presented at 36th Critical Care Congress, Orlando, FL. (February 2007)

"Exploring the Link between Mitochondria, Metabolism and MODS during Sepsis." Presented at American College of Veterinary Internal Medicine, San Antonio, Texas. (June 2008)

"Innate immune responses to mitochondrial antigens: The link between acute cell death and sterile inflammation?." Presented at Research Retreat, . (October 2008)

"Pathogenesis of Organ Failures During Sepsis: More Questions than Answers." Presented at Research Conference, . (March 2008)

"Exploring the link between cell damage and inflammation: A newly discoverd role of mitochondria." Presented at Research Conference, . (March 2008)

"Everything you wanted to know about Mitochondria but were afraid to ask." Presented at American Thoracic Society International Conference, Toronto, Canada. (May 2008)

"Sepsis and MODS: The Human Perspective." Presented at American College of Veterinary Internal Medicine, San Antonio, Texas. (June 2008)

"Insights from a Genome-Wide Gene Array Analysis of Pulmonary Sarcoidosis." Presented at Research In Progress, . (June 2008)

"Sarcoidosis: Current State-of-the-Art." Presented at Fellow's Medical School, . (July 2009)

"The role of microcirculatory disturbances in pathogenesis of sepsis-induced mutliple organ dysfunction." Presented at American Thoracic Society International Conference, San Diego, California. (May 2009)

"In Silico modeling of sarcoidosis granuloma formation implicates TNFa and regulatory T cells (Tregs) as critical therapeutic targets." Presented at American Thoracic Society International conference, Orleans, California. (May 2010)

"Sarcoidosis." Presented at Resident Lecture Series, . (July 2010)

"Sarcoidosis: Current State-of-the-Art." Presented at Fellow's Medical School, . (August 2010)

"MicroRNA targets the neopterin pathway in pulmonary sarcoidosis." Presented at American Thoracic Society International meeting, Denver, Colorado. (May 2011)

"Sarcoidosis: Current State-of-the-Art." Presented at Fellow's Medical School, . (August 2011)

"Evaluation and Management of Sarcoidosis." Presented at 4th Annual Midwestern Dermatology Resident Review Course, . (August 2011)

 

Professional Activities

2003 - present Burroughs Wellcome Foundation.
2004 - present American Lung Association (Ohio Chapter).
2006 - present Davis Heart & Lung Research Institute, Intramural Grants.
2006 - present American Thoracic Society. ATS Meeting.
2003 - 2009 Society of Critical Care Medicine, Vision Grants.
2005 - 2009 SCCM Meetings. Society for Critical Care Medicine.