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Elliott D. Crouser, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-4925

Email: crouser.1@osu.edu

 

Current OSU Appointments

Associate Professor, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

 

Biographical

In addition to running the Sarcoidosis Clinic at OSU, Dr. Crouser is the Section Chief for the Division of Pulmonary and Critical Care Medicine and Medical Director of the ICU at University Hospital East (an affiliate of The Ohio State University Medical Center in Columbus, OH). Under his leadership the ICU structure has been optimized to deliver outstanding care (below target length-of-stay; risk adjusted mortality consistently <0.5) while providing expanded services (e.g., new stroke and acute myocardial infarction initiatives, increasing census). He also serves as an Editor for Critical Care Medicine, the top-ranked journal specializing in critical care, and reviews or serves on editorial boards for more than 20 other journals. He has served on NIH study sections, including an ongoing temporary appointment to the Surgery Anesthesia and Trauma study section (for 3 consecutive cycles), and has also reviewed grants for the Society of Critical Care Medicine, Wellcome Trust (London) and other extramural funding agencies. Dr. Crouser is actively funded by extramural sources for over 15 years, including ongoing support from the NIH to investigate inflammatory diseases that involve the lungs and other organs in the context of acute and chronic illness. His laboratory is among the first to have identified mitochondria as critical mediators of cell and organ dysfunction in the setting of acute systemic inflammatory diseases, including sepsis. His genomic studies in the field of pulmonary sarcoidosis identified novel disease mechanisms and "biomarkers" of disease progression. Ongoing studies in these areas of research promise to provide targets for new treatments for these poorly understood diseases.

Certifications

1992 - present Board Certification: American Board of Internal Medicine
1994 - present Board Certification: American Board of Internal Medicine
1995 - present Medical License: State Medical Board of Ohio
1995 - present Board Certification: American Board of Internal Medicine
2004 - present Board Re-Certification: American Board of Internal Medicine
2004 - present Board Re-Certification: American Board of Internal Medicine
2014 - present Board Re-Certification: American Board of Internal Medicine
 

Chapters in Books

Crouser ED, St. John RC. "Clinical assessment of tissue oxygenation." In Seminars in Respiratory and Critical Care Medicine: Oxygen Consumption and Transport in the Critically Ill.. Edited by Dorinsky PM. 382-93. New York, NY: Thieme Medical Publishers, Inc, January 1995.

Crouser ED, Fahy RJ. "Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome." In Egan’s Fundamentals of Respiratory Care, Eighth Edition. Edited by Scanlon C, Wilkins and Stoller J. -. St. Louis, MO: Mosby-Year Book, Inc., January 2002.

Crouser ED, Dorinsky PM. "Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome." In Egan’s Fundamentals of Respiratory Care, Seventh Edition. Edited by Scanlon C, Wilkins and Stoller J. -. St. Louis, MO: Mosby-Year Book, Inc., January 2003.

Fahy RJ, Crouser ED. "Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome." In Egan’s Fundamentals of Respiratory Care, Ninth Edition. -. St. Louis, MO: Mosby-Year Book, Inc., January 2009.

Fahy RJ, Crouser ED. "Acute Lung Injury, Pulmonary Edema and Multiple Organ Dysfunction Syndrome." In Egan’s Fundamentals of Respiratory Care, Ninth Edition. -. St. Louis, MO: Mosby-Year Book, Inc., January 2013.

Besecker, B, Crouser, ED. "Pulmonary Edema." In Textbook of Critical Care. -. Philadelphia, PA: Elsevier, January 2015.

Exline, M, Crouser, ED. "Pathogenesis of Organ Failure During Sepsis." In .. -.

 

Clinical Services

01/01/1995 Pulmonary Sarcoidosis Outpatient Clinic (Martha Morehouse Medical Pavilion)
01/01/1995 MICU; 4 Doan ICU; OSU East; James,Ross, and UH Consult; Pulmonary Ward; Select; and Risk IP Services (Various Locations Affiliated with The Ohio State University Medical Center)

Conferences

Crouser,E; Julian,M; OVERDAHL,M; Dorinsky,P. "ACID-INDUCED LUNG INJURY RESULTS IN ENDOTHELIAL INJURY WITHOUT ALTERING THE VO2-DO1 RELATIONSHIP IN THE ILEUM." In CLINICAL RESEARCH. (October 1994). A372-A372.

Crouser,E; Bauer,J; Weinstein,D; Blaho,D; Julian,M. "Endotoxin-induced mitochondrial injury in the ileum is attenuated by a free radical spin trap." In FREE RADICAL BIOLOGY AND MEDICINE. (January 1998). S83-S83.

Crouser,E,D; Julian,M,W. "Sepsis-induced ileal mitochondrial injury correlates with altered oxygen metabolism.." In JOURNAL OF INVESTIGATIVE MEDICINE. (September 1998). 256A-256A.

Crouser,E; Blaho,D; Julian,M. "Despite maintenance of mucosal blood flow, endotoxin-induced mitochondrial injury and altered VO2-DO2 relationships occur in the ileum.." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (March 1999). A610-A610.

Crouser,E,D; Julian,M,W; Weinstein,D,M; Bauer,J,A. "Nitric oxide dysregulation correlates with mitochondrial injury in the ileum following endotoxin.." In FASEB JOURNAL. (March 1999). A184-A184.

Crouser,E,D; Blaho,D,V; Julian,M,W. "Hepatic mitochondrial oxygen metabolism is impaired during endotoxemia.." In FREE RADICAL BIOLOGY AND MEDICINE. (January 1999). S104-S104.

Julian,M; Blaho,D; Weinstein,D; Bauer,J; Crouser,E. "Free radical scavenging prevents the development of endotoxin-induced alterations in ileal microvascular permeability and VO2-DO2 relationships.." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (March 1999). A610-A610.

Crouser,E; Blaho,D; Julian,M. "Endotoxin-induced VO2-DO2 alterations and mitochondrial injury occur in the ileum without a decrease in ileal oxyhemoglobin levels.." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (March 1999). A611-A611.

Pfeiffer,D,R; Brockemeier,K,M; Crouser,E,D. "Ca2+ independent phospholipase A(2) (PLA(2)) of possible significance in initiating mitochondrial apoptosis." In BIOPHYSICAL JOURNAL. (January 2002). 22A-23A.

Gadd,M,E; Julian,M,W; Crouser,E,D; Pfeiffer,D,R. "Analytical quantitation of cytochrome c release from rat liver mitochondria." In BIOPHYSICAL JOURNAL. (January 2002). 111A-111A.

Crouser,E; Gadd,M; Julian,M; Huff,J; Pfeiffer,D. "Fractional cytochrome c release from isolated rat mitochondria quantified with reverse-phase HPLC.." In FASEB JOURNAL. (March 2002). A1184-A1184.

Crouser,E,D; Julian,M,W; Morales,J. "Cardiac dysfunction is associated with myocyte mitochondrial injury in a resuscitated model of acute bacterial sepsis." In CRITICAL CARE MEDICINE. (December 2002). A53-A53.

Crouser,E,D; Julian,M,W; Morales,J; Joshi,M,S; Bauer,J,A. "Cardiac dysfunction is associated with myocyte mitochondrial injury in a resuscitated model of acute bacterial sepsis." In CRITICAL CARE MEDICINE. (February 2003). A53-A53.

Joshi,M,S; Julian,M; Crouser,E,D; Bauer,J,A. "Cardiac dysfunction, mitochondrial ultrastructural injury, and NOS2 induction in a feline model of acute sepsis." In FASEB JOURNAL. (March 2003). A216-A216.

Gadd,M,E; Crouser,E,D; Julian,M,W; Erdahl,W,L; Huff,J,E; Pfeiffer,D,R. "Mituchondrial iPLA(2) activity promotes release of cytochrome c." In FASEB JOURNAL. (March 2003). A678-A678.

Joshi,M,S; Julian,M,W; Crouser,E,D; Bauer,J,A. "Left ventricular dysfunction in a feline model of acute sepsis: Relation to NOS2 induction and mitochondrial ultrastructural injury." In PEDIATRIC RESEARCH. (April 2003). 44A-44A.

Crouser,E,D. "Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome." In MITOCHONDRION. (September 2004). 729-741.

Crouser,E; Cook,C; Julian,M; Huff,J. "Impaired mitochondrial function and structure in the liver during subacute sepsis." In PROCEEDINGS OF THE 6TH WORLD CONGRESS ON TRAUMA, SHOCK, INFLAMMATION AND SEPSIS- PATHOPHYSIOLOGY, IMMUNE CONSEQUENCES AND THERAPY. (January 2004). 199-204.

Crouser,E; Cook,C; Julian,M; Huff,J. "Damage and depletion of mitochondria in the liver during CLP sepsis." In SHOCK. (January 2004). 58-58.

Joshi,M,S; Bauer,J,A; Julian,M,W; Crouser,E,D. "Prevention of sepsis related cardiac dysfunction and mitochondrial injury by Cyclosporin A in a feline model of acute sepsis." In FASEB JOURNAL. (March 2004). A591-A592.

Joshi,M,S; Bauer,J,A; Julian,M,W; Crouser,E,D. "Cyclosporin A attenuates left ventricular dysfunction in a feline model of acute sepsis: relation to TLR4 induction, NOS2 induction and protein nitration." In FASEB JOURNAL. (March 2004). A592-A592.

Joshi,M,S; Julian,M,W; Crouser,E,D; Bauer,J,A. "Cyclosporin A prevents sepsis related cardiac dysfunction and mitochondrial injury in a feline model of acute sepsis." In PEDIATRIC RESEARCH. (April 2004). 61A-61A.

Joshi,M,S; Julian,M,W; Crouser,E,D; Bauer,J,A. "Attenuation of left ventricular dysfunction in a feline model of acute sepsis by cyclosporin A: Relation to TLR4 induction, NOS2 induction and protein nitration." In PEDIATRIC RESEARCH. (April 2004). 61A-61A.

Crouser,E; Julian,M; Fahy,R; Knoell,D. "The susceptibility to mitochondriial damage differs in vital organs in the context of sepsis.." In SHOCK. (January 2005). 14-14.

Lucas,David,M; Hussain,Syed-Rehan,A; Johnson,Amy,J; Smith,Lisa,L; Wagner,Amy,J; Allison,Jamie,M; Guster,Sara,E; Lin,Thomas,S; Byrd,John,C; Julian,Mark,W; Crouser,Elliott,D; Grever,Michael,R. "Flavopiridol decreases Mcl-1 and initiates early mitochondrial damage in chronic lymphocytic leukemia (CLL) cells.." In BLOOD. (November 2006). 595A-595A.

Crouser,Elliott; Julian,Mark; Shao,Guohong; Huff,Jennifer; Wewers,Mark; Hart,Judith. "Induction of inflammation by mitochondrial proteins.." In CRITICAL CARE MEDICINE. (December 2006). A16-A16.

Crouser,Elliott,D; Shao,Guohong; Julian,Mark,W; Tridandapani,Susheela. "MITOCHONDRIAL TRANSCRIPTION FACTOR A (TFAM) PROMOTES DENDRITIC CELL ACTIVATION VIA RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS (RAGE).." In CRITICAL CARE MEDICINE. (December 2008). A29-A29.

Crouser,E,D; Shao,G; Julian,M,W; Huang,Q; Bao,S. "PI-3K Is Essential for Plasmacytoid Dendritic Cell Type I IFN Responses to Mitochondrial Transcription Factor A (TFAM) and CpG DNA." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2009). .-.

Crouser,E,D; Julian,M,W; Shao,G; Fox,C; Hauswirth,D; Jehn,J; Lozanski,G; Erdal,S; WEWERS,M,D. "Infliximab Reverses Peripheral CD4+T Cell Depletion in Lymphopenic Sarcoidosis Patients." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2009). .-.

Crouser,Elliott; Shao,Guohong; Julian,Mark. "MITOCHONDRIAL DANGER SIGNALS PROMOTE LUNG EPITHELIAL CELL IL-8 RELEASE VIA FORMYL PEPTIDE RECEPTORS." In CRITICAL CARE MEDICINE. (December 2009). A31-A31.

Julian,M; Shao,G; Crouser,E,D. "Mitochondrial Antigens are Selectively Recognized by TLR-2 in the Context of Cell Necrosis." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2010). .-.

Crouser,E,D; Julian,M; Shao,G; Crawford,M; Culver,D,A; Nana-Sinkam,P. "MicroRNA Targets The Neopterin Pathway In Pulmonary Sarcoidosis." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2011). .-.

Julian,Mark; Shao,Guohong; Vangundy,Zack; Papenfuss,Tracey; Crouser,Elliott. "MITOCHONDRIAL TRANSCRIPTION FACTOR A (TFAM), A DANGER SIGNAL RELEASED FROM DAMAGED CELLS, PROMOTES AN INNATE IMMUNE IN THROUGH RAGE AND TLR9 SIGNALING PATHWAYS." In CRITICAL CARE MEDICINE. (December 2012). U20-U20.

Ono,Chikako; Crouser,Elliott; Raman,Subha,V. "Myocardial T2 is Increased in Sarcoidosis to a Greater Extent Compared to Late Gadolinium Enhancement." In CIRCULATION. (November 2013). .-.

Chang,Henry; Tam Tran,T; Billman,George,E; Julian,Mark; Hamlin,Robert; Simonetti,Orlando; Ambrosio,Giuseppe; Shao,Guohong; Crouser,Elliott,D; Raman,Subha,V. "Ex-vivo Signatures of Myocardial Edema by in-vivo T2-CMR in a Novel Large Animal Model of NSTE-ACS." In CIRCULATION. (November 2013). .-.

Crouser,Elliott; Julian,Mark; Vangundy,Zack; Papenfuss,Tracey. "Cross-suppression of TLR4-and TLR9-mediated immune responses in a murine splenocyte culture model." In CRITICAL CARE MEDICINE. (December 2013). .-.

Crouser,Elliott; Julian,Mark; Strange,Heather; Ballinger,Megan; Hotchkiss,Richard; Papenfuss,Tracey. "TLR4-AND TLR9-MEDIATED IMMUNE TOLERANCE AND CROSS-TOLERANCE IS ATTENUATED BY IL-7." In CRITICAL CARE MEDICINE. (December 2014). .-.

 

Degrees

1983 B.A., Oberlin College

1989 M.D., Medical College of Ohio

 

Editorial Activities

present The Online Journal of Critical Care Medicine
present Biochimica et Biophysica Acta
2006 - present Critical Care Medicine
2007 - present Respiratory Medicine (ISI impact factor 2.0)
2007 - present Proteomics (ISI impact factor 4.1)
2007 - present Intensive Care Medicine (ISI impact factor 5.4)
2007 - present Journal of Biological Chemistry (ISI impact factor 4.6)
2007 - present Antioxidants and Redox Signaling (ISI impact factor 7.2)
2007 - present Letters in Drug Design and Discovery
2007 - present American Journal of Physiology (ISI impact factor 4.2)
2007 - present American Journal of Pulmonary and Critical Care Medicine (ISI impact factor 11.0)
2007 - present Toxicology (ISI impact factor 4.0)
2007 - present BMC Cancer (ISI impact factor 3.3)
2007 - present Lancet (England) (ISI impact factor 39.1)
2007 - present Cell & Tissue Research (ISI impact factor 3.7)
2007 Regulatory Toxicology and Pharmacology
2007 Frontiers in Biosciences
2007 Critical Care Medicine
2007 “F1000 Medicine” (online journal review)
2008 - present Critical Care Medicine (ISI Impact Factor 6.4) Recognized as a "Top 10" Reviewer 2008-2013
2014 - present PLOS One
 

Honors

1988 - 1989 Alpha Omega Alpha. The Medical College of Ohio at Toledo.
1994 - 1995 James V. Warren Award. Department of Medicine, The Ohio State University Department of Internal Medicine.
1999 - 2000 Parker B. Francis Fellow of Pulmonary Research. Harvard School of Public Medicine.
2000 - 2005 Mentored Clinical Scientist Award. National Institutes of Health.
2001 - 2004 Career Investigator Award. American Lung Association.
2005 - 2014 America's Best Doctors. U.S. News & World Report.
2008 - 2009 Reseracher of the Year. Foundation of Sarcoidsos Research.
2009 Immunology Research Award (top immunology presentation). Society of Critical Care Medicine.
2013 Annual Scientific Award (overall top 10 research presentation). Society of Critical Care Medicine.
 

Journal Articles

Hulman, S; Kliegman, R; Heng, J; Crouser E. "Relationship of substrate level to turnover rate in fasted adult and newborn dogs.." The American journal of physiology. Vol. 254, no. 2 Pt 1. (January 1988.): E137-43.

Crouser E; Dorinsky, P M. "Gastrointestinal tract dysfunction in critical illness: pathophysiology and interaction with acute lung injury in adult respiratory distress syndrome/multiple organ dysfunction syndrome.." New horizons (Baltimore, Md.). Vol. 2, no. 4. (January 1994.): 476-87.

Crouser E; Julian, M, W; Weisbrode, S, E; Dorinsky, P M. "Acid aspiration results in ileal injury without altering ileal V(O2)-D(O2) relationships.." American journal of respiratory and critical care medicine. Vol. 153, no. 6 Pt 1. (January 1996.): 1965-71.

Crouser E; Dorinsky, P M. "Metabolic consequences of sepsis. Correlation with altered intracellular calcium homeostasis.." Clinics in chest medicine. Vol. 17, no. 2. (January 1996.): 249-61.

Crouser E; Julian, M, W; Weisbrode, S, E; Dorinsky, P M. "Ischemia/reperfusion injury to the ileum does not account for the ileal VO2-DO2 alterations induced by endotoxin.." Journal of critical care. Vol. 12, no. 4. (January 1997.): 200-7.

Crouser E; Julian, M, W; Weisbrode, S, E; Dorinsky, P M. "Endotoxin-induced ileal Vo2-Do2 alterations do not correlate with the severity of ileal injury.." Journal of critical care. Vol. 12, no. 2. (January 1997.): 83-91.

Dorinsky PM, Crouser ED. "Oxygen Delivery in Critically Ill Patients." Mediguide. Vol. 4, (January 1997.): 1-5.

Crouser E; Julian, M, W; Dorinsky, P M. "Ileal VO(2)-O(2) alterations induced by endotoxin correlate with severity of mitochondrial injury.." American journal of respiratory and critical care medicine. Vol. 160, no. 4. (January 1999.): 1347-53.

Joshi, M, S; Crouser E; Julian, M, W; Schanbacher, B, L; Bauer, J A. "Digital imaging analysis for the study of endotoxin-induced mitochondrial ultrastructure injury.." Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. Vol. 21, no. 1. (January 2000.): 41-8.

Fahy, R, J; Crouser E; Pacht, E R. "Herpes simplex type 2 causing fulminant hepatic failure.." Southern medical journal. Vol. 93, no. 12. (January 2000.): 1212-6.

Crouser E; Julian, M, W; Weinstein, D, M; Fahy, R, J; Bauer, J A. "Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated.." American journal of respiratory and critical care medicine. Vol. 161, no. 5. (January 2000.): 1705-12.

Weil MH, Becker L, Kern K, Nichol G, Shechter I, Traystman R, Wiedemann H, Wise R, Weisfeldt M, Sopko G and participants in the "PULSE workshop" (including Crouser E). "Workshop Summary Report: Post-Resuscitative and Initial Utility in Life Saving Efforts (PULSE)." Circulation. no. 103. (January 2001.): 1182-1184.

Crouser, Elliott D; Julian, Mark, W; Joshi, Mandar, S; Bauer, John, A; Wewers, Mark, D; Hart, Judith, M; Pfeiffer, Douglas R. "Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia.." Critical care medicine. Vol. 30, no. 12. (January 2002.): 2722-8.

Crouser ED; Julian, Mark, W; Blaho, Dorottya, V; Pfeiffer, Douglas R. "Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity.." Critical care medicine. Vol. 30, no. 2. (January 2002.): 276-84.

Backer LB, Weisfeldt ML, Weil MH, Budinger T, Carico J, Kern K, Nichol G, Shechter I, Traystman R, Webb C, Wiedemann H, Sopko G, and participants in the "PULSE Workshop" (including Crouser E). "The PULSE Initiative: Scientific Priorities and Strategic Planning for Resuscitation Research and Life Saving Therapies." Circulation. no. 105. (January 2002.): 2562-2570.

Broekemeier, Kimberly, M; Iben, James, R; LeVan, Emily, G; Crouser; Pfeiffer, Douglas R. "Pore formation and uncoupling initiate a Ca2+-independent degradation of mitochondrial phospholipids.." Biochemistry. Vol. 41, no. 24. (January 2002.): 7771-80.

Crouser ED; Julian, Mark, W; Huff, Jennifer, E; Broekemeier, Kimberly, M; Robbins, Karen, A; Pfeiffer, Douglas R. "Quantitation of cytochrome c release from rat liver mitochondria.." Analytical biochemistry. Vol. 317, no. 1. (January 2003.): 67-75.

Lucarelli, Maria, R; Shirk, Mary Beth; Julian, Mark, W; Crouser, Elliott D. "Toxicity of Food Drug and Cosmetic Blue No. 1 dye in critically ill patients.." Chest. Vol. 125, no. 2. (January 2004.): 793-5.

Crouser ED; Huff, Jennifer, E; Joshi, Mandar, S; Bauer, John, A; Gadd, Martha, E; Wewers, Mark, D; Pfeiffer, Douglas R. "Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia.." Critical care medicine. Vol. 32, no. 2. (January 2004.): 478-88.

Crouser ED. "Therapeutic benefits of antioxidants during sepsis: is protection against oxidant-mediated tissue damage only half the story?." Critical Care Medicine. Vol. 32, no. 2. (February 2004.): 589-.

Crouser ED. "Mitochondrial Dysfunction in Septic Shock and Multiple Organ Dysfunction Syndrome." Mitochondrion. Vol. 4, (January 2004.): 729-741.

Crouser E, Cook C, Julian M, Huff J. "Impaired mitochondrial function and structure in the liver during subacute sepsis." Proceedings of the 6th World Congress on Trauma, Shock, Inflammation and Sepsis. (January 2004.): 199-201.

Crouser ED. "Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome.." Mitochondrion. Vol. 4, no. 5-6. (September 2004.): 729-.

Crouser, Elliott D. "Redefining the roles of apoptosis pathways during sepsis.." Critical care medicine. Vol. 33, no. 3. (January 2005.): 670-2.

Crouser E. "Is cell death a prerequisite for cardiac dysfunction during sepsis?." Critical care medicine. Vol. 33, no. 5. (January 2005.): 1160-2.

Crouser, Elliott D. "Respiratory failure during critical illness: are mitochondria to blame?." American journal of respiratory and critical care medicine. Vol. 172, no. 7. (January 2005.): 793-4.

Fahy RJ, Crouser ED. "Summary of International Conference of the American Thoracic Sociey." Advances in Sepsis. Vol. 4, (January 2005.): 154-156.

Crouser, Elliott, D; Julian, Mark, W; Huff, Jennifer, E; Struck, Joachim; Cook, Charles H. "Carbamoyl phosphate synthase-1: a marker of mitochondrial damage and depletion in the liver during sepsis.." Critical care medicine. Vol. 34, no. 9. (January 2006.): 2439-46.

Crouser, Elliott, D; Julian, Mark, W; Huff, Jennifer, E; Mandich, David, V; Green-Church, Kari B. "A proteomic analysis of liver mitochondria during acute endotoxemia.." Intensive care medicine. Vol. 32, no. 8. (January 2006.): 1252-62.

O'Brien JM, Crouser ED. "35th Critical Care Congress of the Society of Critical Care Medicine." Advances in Sepsis. Vol. 5, (January 2006.): 120-122.

Gadd, Martha, E; Broekemeier, Kimberly, M; Crouser, Elliott, D; Kumar, Jitendra; Graff, Gustav; Pfeiffer, Douglas R. "Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition.." The Journal of biological chemistry. Vol. 281, no. 11. (January 2006.): 6931-9.

Joshi, Mandar, S; Julian, Mark, W; Huff, Jennifer, E; Bauer, John, A; Xia, Yong; Crouser, Elliott, D. "Calcineurin regulates myocardial function during acute endotoxemia.." American journal of respiratory and critical care medicine. Vol. 173, no. 9. (January 2006.): 999-1007.

Wynbrandt, Jonathan, H; Crouser, Elliot D. "Transformation of pulmonary histoplasmosis to sarcoidosis: a case report.." Respiratory medicine. Vol. 101, no. 4. (January 2007.): 863-4.

Ezzie,Michael,E; Crouser,Elliott,D. "Considering an infectious etiology of sarcoidosis." CLINICS IN DERMATOLOGY. Vol. 25, no. 3. (May 2007.): 259-266.

Crouser ED. "Suppression of monocyte metabolism by septic plasma: revisiting the concept of "blood poisoning".." Critical Care Medicine. Vol. 35, (January 2007.): 2856-2857.

Hoffmann S, Crouser ED. "Mitochondrial Mechanisms if Organ Dysfunction During Sepsis." Advances in Sepsisq. Vol. 6, (January 2007.): 2-9.

Hussain SRA, Lucas DM, Johnson AJ, Lin TS, Bakaletz AP, Viatchenko-Karpinski S, Dang VX, Kuppusamy P, Crouser E, Byrd JC, Grever MR. "Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium." Blood. no. 111. (January 2008.): 3190-3199.

Crouser ED, Exline M, Knoell D, Wewers MD. "Sepsis: links between pathogen sensing and organ damage." Current Pharmaceutical Design. Vol. 14, (January 2008.): 1840-1852.

Belknap JK, Moore JN, Crouser ED. "Sepsis- From Organ Failure to Laminar Failure." Veterinary Immunology and Immunopathology. Vol. 129, (November 2008.): 155-7.

Exline,Matthew,C; Crouser,Elliot,D. "Mitochondrial mechanisms of sepsis-induced organ failure." FRONTIERS IN BIOSCIENCE-LANDMARK. Vol. 13, (May 2008.): 5030-5041.

Crouser, ED. "What is Sarcoidosis." Ask an Expert Series: Cleveland Plain Dealer. Vol. /, (April 2008.): .-.

Exline MC, Crouser ED. "Mitochondrial mechanisms of sepsis-induced organ failure." Frontiers in Bioscience. Vol. 13, (January 2008.): 5030-5041.

Ali NA, O'Brien JM, Hoffmann SP, Phillips G, Garland A, Findley JC, Almoosa K, Hejal R, Wolf KM, Lemeshow S, Connors AF, Marsh CB. "Acquired weakness, handgrip strength, and mortality in critically ill patients." American Journal of Respiratory and Critical Care Medicine. Vol. 178, (August 2008.): 261-268.

Knoell DL, Julian MW, Bao S, Besecker B, Huff JE, Leikauf G, DiSilvestro R, Crouser E. "Mortaligy is Significantly Increased by Zinc Deficiency in an Adult Murine Model of Polymicrobial Sepsis." Critical Care Medicine. no. 37. (January 2009.): 1380-1388.

Crouser E, Culver DA, Huff JE, Julian MW, Shao G, Liyanarachchi S, Knox KS, Macre JE, Wewers MD, Gavrilin M, Ross P, Abbas A, Eng C. "Gene Expression Profiling Identifies MMP-12 and ADAMDEC1 as Potential Pathogenic Mediators of Pulmonary Sarcoidosis." Am J Respir Critical Care Medicine. no. 179. (January 2009.): 929-938.

Crouser,Elliott,D; Shao,Guohong; Julian,Mark,W; Macre,Jennifer,E; Shadel,Gerald,S; Tridandapani,Susheela; Huang,Qin; Wewers,Mark,D. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." CRITICAL CARE MEDICINE. Vol. 37, no. 6. (June 2009.): 2000-2009.

Knoell,Daren,L; Julian,Mark,W; Bao,Shengying; Besecker,Beth; Macre,Jennifer,E; Leikauf,George,D; DiSilvestro,Robert,A; Crouser,Elliott,D. "Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis." CRITICAL CARE MEDICINE. Vol. 37, no. 4. (April 2009.): 1380-1388.

Rosenbaum JT, Pasadhika S, Crouser E, Harrington CA, Choi D, Smith JR, Braziel RM, Vance EE, Planck SR. "Hypothesis: Sarcoidosis is a STAT1-mediated disease." Clinical Immunology. no. 132. (January 2009.): 174-183.

Pompili VJ; Crouser ED. "Stem cell therapy: A "magic bullet" for cardiomyopathies?." Critical Care Medicine. Vol. 37, no. 4. (April 2009.): 1487-.

Crouser E, Lozanski G, Fox CC, Hauswirth DW, Raveendran R, Julian MW. "The CD4+lymphopeni sarcoidosis phenotype is highly responsive to anti-TNF therap." Chest. no. 137. (January 2010.): 1432-1435.

Crouser ED. "Peroxisome proliferator-activated receptors gamma coactivator-1alpha: master regulator of mitochondrial biogenesis and survival during critical illness?." American Journal Of Respiratory And Critical Care Medicine. Vol. 182, no. 6. (September 2010.): 726-.

Nana-Sinkam SP; Crouser ED. "Altered immune surveillance: a common link between cancer and sepsis?." Critical Care Medicine. Vol. 38, no. 3. (March 2010.): 1000-.

Shao,Guohong; Julian,Mark,W; Bao,Shengying; McCullers,Meghan,K; Lai,Ju-Ping; Knoell,Daren,L; Crouser,Elliott,D. "Formyl Peptide Receptor Ligands Promote Wound Closure in Lung Epithelial Cells." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 44, no. 3. (March 2011.): 264-269.

Julian,Mark,W; Bao,Shengying; Knoell,Daren,L; Fahy,Ruairi,J; Shao,Guohong; Crouser,Elliott,D. "Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis." INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. Vol. 92, no. 5. (October 2011.): 366-376.

Crouser,Elliott,D; Parinandi,Narasimham. "Mitochondrial mechanisms are at the 'heart' of novel ischemia-reperfusion therapies." CRITICAL CARE MEDICINE. Vol. 39, no. 3. (March 2011.): 593-595.

Exline,Matthew,C; Crouser,Elliott,D. "Mitochondrial dysfunction during sepsis: Still more questions than answers." CRITICAL CARE MEDICINE. Vol. 39, no. 5. (May 2011.): 1216-1217.

Aguda, B, Thacker, M, Marsh, CB, Crouser, ED. "An In Silico Modeling Approach to Understanding the Dynamics of Sarcoidosis." PLoS One. Vol. 6, no. 5. (May 2011.): e19544-.

Erdal,Barbaros,Selnur; Crouser,Elliott,D; Yildiz,Vedat; King,Mark,A; Patterson,Andrew,T; Knopp,Michael,V; Clymer,Bradley,D. "Quantitative Computerized Two-Point Correlation Analysis of Lung CT Scans Correlates With Pulmonary Function in Pulmonary Sarcoidosis." CHEST. Vol. 142, no. 6. (December 2012.): 1589-1597.

Julian,Mark,W; Shao,Guohong; Bao,Shengying; Knoell,Daren,L; Papenfuss,Tracey,L; Vangundy,Zachary,C; Crouser,Elliott,D. "Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 1. (July 2012.): 433-443.

Erdal,Barbaros,S; Clymer,Bradley,D; Yildiz,Vedat,O; Julian,Mark,W; Crouser,Elliott,D. "Unexpectedly high prevalence of sarcoidosis in a representative US Metropolitan population." RESPIRATORY MEDICINE. Vol. 106, no. 6. (June 2012.): 893-899.

Crouser,Elliott,D; Julian,Mark,W; Crawford,Melissa; Shao,Guohong; Yu,Lianbo; Planck,Stephen,R; Rosenbaum,James,T; Nana-Sinkam,S,Patrick. "Differential expression of microRNA and predicted targets in pulmonary sarcoidosis." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 417, no. 2. (January 2012.): 886-891.

Crouser,Elliott,D. "Warming up to hypothermia for treatment of severe sepsis." CRITICAL CARE MEDICINE. Vol. 40, no. 3. (March 2012.): 1020-1022.

Chacey, MD, Crosser, MS, Crouser, ED. "Metabollic Acidosis in Acetaminophen Overdose Without Concurrent Liver Toxicity." Kansas J Med. Vol. 5, (January 2012.): 12-18.

Julian,Mark,W; Shao,Guohong; Schlesinger,Larry,S; Huang,Qin; Cosmar,David,G; Bhatt,Nitin,Y; Culver,Daniel,A; Baughman,Robert,P; Wood,Karen,L; Crouser,Elliott,D. "Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis." CHEST. Vol. 143, no. 2. (February 2013.): 461-470.

Julian,Mark,W; Shao,Guohong; Vangundy,Zachary,C; Papenfuss,Tracey,L; Crouser,Elliott,D. "Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNF alpha Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells." PLOS ONE. Vol. 8, no. 8. (August 2013.): .-.

Chang,Henry; Tam Tran,T; Billman,George,E; Julian,Mark,W; Hamlin,Robert,L; Simonetti,Orlando,P; Ambrosio,Giuseppe; Baker,Peter,B; Shao,Guohong; Crouser,Elliott,D; Raman,Subha,V. "At-risk but viable myocardium in a large animal model of non ST-segment elevation acute coronary syndrome: cardiovascular magnetic resonance with ex vivo validation." JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE. Vol. 15, (October 2013.): 94-.

Siddiqui, Y, Crouser, ED, Raman, SV. "Non-Ischemic Myocardial Changes Detected by Cardiac Magnetic Resonance in Critical Care Patients with Sepsis." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 188, no. 8. (October 2013.): 1037-1039.

Sopirala, M, Smyer, J, Fawley, L, Mangino, JE, Lustberg, ME, Lu, J, Chucta, S, Crouser, ED. "Sustained Reduction of Central Line Associated Blood Stream Infections in an Intensive Care Unit Using a Top-Down and Bottom-Up Approach." AMERICAN JOURNAL OF INFECTION CONTROL. Vol. 41, no. 2. (February 2013.): 183-184.

Crouser, ED. "Autophagy: The First Step Towards Recovery from Critical Illness." Crit Care Med. Vol. 41, (January 2013.): 358-9.

Crouser, ED. "A Rare Glimpse Behind the Mask of Sepsis-Induced Organ Failutes Provides Hope for an Eventual Cure." Am J. Respir Crit Care med. Vol. 187, (January 2013.): 460-2.

Crouser, ED, Ono, C, He, X, Raman, SV. "Improved Detection of Cardiac Sarcoidosis Using Magnetic Resonance with Myocardial T2 Mapping." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 189, no. 1. (January 2014.): 109-112.

Schumacker, PT, Gillespie, MN, Nakahira, K, Choi, AMK, Crouser, ED, Piantadosi, CA, Battacharya, J. "The New Biology of Mitochondria in the Lung; More than Just a Powerhouse.." Am J Physiol-Lung Cell Mol Physiol. Vol. 31, (January 2014.): 19-27.

Judson, MA, Baughman, RP, Costabel, U, Drent, M, Wells, A, Maier, L, Koth, L, Shigemitsu, H, Culver, DA, Valeyre, D, Sweiss, N, Crouser, E, Morgenthau, AS, Lower, EE, Rosenbach, M, (THe WASOG Sarcoidosis ORgan Assessment Instrument Investigators). "The WASOG Sarcoidosis Organ Assessment Instrument; An update of a previous clinical tool.." Sarcoidosis Vasc Diffuse Lung Disease. Vol. 31, no. 1. (January 2014.): 19-27.

Crouser,Elliot,D; Judson,Marc,A. "PROCEEDINGS OF THE 2014 AASOG CONFERENCE." SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. Vol. 31, no. 4. (January 2014.): 359-363.

Hao, W, Crouser, ED, Friedman, A. "A Mathematical Model of Sarcoidosis." Proceedings of the National Academies, USA. Vol. 111, no. 45. (November 2014.): 16065-16070.

Amin, EN, Closser, DR, Crouser, ED. "Current Best Practice in the Management of Pulmonary and Systemic Sarcoidosis." Therapeutic Advances in Respiratory Disease. Vol. 8, no. 4. (August 2014.): 111-132.

Evanchan, J, Crouser, ED, Kalbfleisch, S. "Cardiac Sarcoidosis: Recent Advances in DIangosis and Treatment and an Argument for the Need for a Systemic Multidisciplinary Approach to Management." Journal of Innovations in Cardiac Rhythm Management. -.

Crouser, ED, Judson, MA. "Proceedings of the 2014 AASOG Conference." Sarcoidosis Vasc Diffuse Lung Dis. -.

 

Reference Works

January 1994 Crouser, E. D.; Julian, M. W.; Overdahl, M. C.; Dorinsky, P. M.."Acid lung injury results in ileal endothelial injury, but not an abnormal VO2-DO2 relationship in the ileum" . : A19
January 1994 Crouser, E. D.; Julian, M. W.; Overdahl, M. C.; Dorinsky, P. M.."Endotoxin-induced alterations in ileal VO2-DO2 relationships are dose-dependent: the role of endothelial injury" . : A652
January 1994 Crouser, E.D.; , Julian, M.W.; Overdahl, M. C.; Dorinsky, P.M.."Acid-induced lung injury results in endothelial injury without altering the VO2-DO2 relationship in the ileum" . : 372A
January 1995 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."High dose endotoxin (LPS), but not ischemia-reperfusion (I/R) injury, causes systemic organ VO2-DO2 alterations" . : A323
January 1995 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Ileal VO2-DO2 alterations are not a direct effect of endotoxin and do not correlate with endothelial injury" . : A338
January 1996 Crouser, E. D..; Julian, M. W.; Dorinsky, P. M.."Ileal VO2-DO2 relationship alterations after endotoxin (LPS) correlate with the extent/severity of mitochondrial injury" . : A466
January 1996 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Diltiazem attenuates endotoxin (LPS)-induced VO2-DO2 alterations and vascular injury in the ileum" . : A465
January 1997 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Energy charge in the ileum is preserved in endotoxin (LPS)-treated animals with normal VO2-DO2 relationships" . : A403
January 1997 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Protein kinase C inhibition attenuates endotoxin (LPS)-induced ileal VO2-DO2 alterations and inflammatory injury" . : A400
January 1997 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Endotoxin (LPS) does not acutely cause mitochondrial ultrastructural damage or VO2-DO2 alterations in the ileum" . : A400
January 1998 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.."Energy charge in the ileum is reduced only in endotoxin (LPS)-treated animals with abnormal VO2-DO2 relationships" . : A103
January 1998 Crouser, E. D.; Julian, M. W.."Sepsis-induced ileal mitochondrial injury correlates with altered oxygen metabolism" . : 256A
January 1998 Crouser, E. D.; Bauer, J. A.; Weinstein D. M; Blaho, D. V; Julian, M. W."Endotoxin-induced mitochondrial injury in the ileum is attenuated by a free radical spin trap" . : S83
January 1998 Swaan, P. W.; Julian, M. W.; Crouser, E. D.."Barrier function of non-ischemic feline ileum after endotoxin (LPS)-induced sepsis" . : S
January 1998 Fahy, R. J.; Julian, M. W.; Wewers, M. D.; Crouser, E. D.."Endotoxin (LPS)-induced ileal cell injury results from necrosis and not apoptosis" . : A103
January 1998 Crouser, E. D.; Julian, M. W.; Dorinsky, P. M.; Bauer, J. A.."Endotoxin (LPS)-induced mitochondrial injury in the ileum correlates with nitric oxide (NO) dysregulation" . : A104
January 1999 Crouser, E. D.; Julian, M. W.; Weinstein, D. M.; Bauer, J. A.; (SPON: Clanton, T. L.)."Nitric oxide dysregulation correlates with mitochondrial injury in the ileum following endotoxin" . : A184
January 1999 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Hepatic mitochondrial oxygen metabolism is impaired during endotoxemia" . : S104
January 1999 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Endotoxin-induced VO2-DO2 alterations and mitochondrial injury occur in the ileum without a decrease in ileal oxyhemoglobin levels" . : A611
January 1999 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Despite maintenance of mucosal blood flow, endotoxin-induced mitochondrial injury and altered VO2-DO2 relationships occur in the ileum" . : A610
January 1999 Julian, M. W.; Blaho, D. V.; Weinstein, D. M; Bauer, J. A.; Crouser, E. D.."Free radical scavenging prevents the development of endotoxin-induced alterations in ileal microvascular permeability and VO2-DO2 relationships" . : A610
January 2000 Goyal, A.; Graham, M. M.; Crouser, E. D.; Marsh, C. B.."Inflammatory cytokines induce monocyte survival via activation of phosphatidylinositol 3-kinase" . : 81
January 2000 Joshi, M. S.; Julian, M. W.; Crouser, E. D,; Bauer, J. A.."Cyclosporin A prevents left ventricular dysfunction in a feline model of acute sepsis: Relation to NOS2 induction, protein nitration and mitochondrial injury" . : A637
January 2000 Crouser, E. D.; Julian, M. W.; Pfeiffer, D. R.."Induction of the permeability transition contributes to mitochondrial injury and altered respiration during endotoxemia" Albany.
January 2000 Crouser, E. D.; Blaho, D. V.; Julian, M. W.."Impairment of mitochondrial oxygen metabolism induced by endotoxin correlates with ultrastructural injury in hepatic mitochondria" . : A880
January 2001 Crouser, E. D.; Julian, M. W.; Pfeiffer, D. R.."Induction of the permeability transition contributes to mitochondrial injury and altered respiration during endotoxemia" . : 101
January 2001 Crouser, E. D.; Julian, M. W.; Blaho, D. V.; Pfeiffer, D. R.."Inhibition of the permeability transition protects against endotoxin-induced mitochondrial injury and respiratory dysfunction" . : A553
January 2002 Crouser, E. D.; Gadd, M. E.; Julian, M. W.; Huff, J. E.; Pfeiffer, D. R.."Fractional cytochrome c release from isolated rat mitochondria quantified with reverse-phase HPLC" . : A1184
January 2002 Gadd, M. E.; Julian, M. W.; Crouser, E. D.; Pfeiffer, D. R.."Analytical quantitation of cytochrome c release from rat liver mitochondria" . : 111a
January 2002 Crouser, E. D.; Julian, M. W.; Joshi, M. S.; Bauer, J. A.."Impaired cardiac contractility is associated with ultrastructurally altered heart mitochondria in acute endotoxemia" . : A472
January 2003 Crouser, E. D.; Julian, M. W.; Morales, J. E.; Joshi, M. S.; Bauer, J. A.."Cardiac dysfunction is associated with myocyte mitochondrial injury in a resuscitated model of acute bacterial sepsis" . : A53
January 2003 Gadd, M. E.; Crouser, E. D.; Julian, M. W.; Erdahl, W. L.; Huff, J. E.; Pfeiffer, D. R.."Mitochondrial iPLA2 activity promotes release of cytochrome c" . : A678
January 2003 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Joshi, M. S.; Bauer, J. A.; Pfeiffer, D. R.."Mitochondrial damage is an early manifestation of sepsis-induced ventricular dysfunction" . : A555
January 2003 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Gadd, M. E.; Erdahl, W. L.; Pfeiffer, D. R.."Abnormal permeability of hepatic outer mitochondrial membranes to cytochrome c during acute endotoxemia" . : A554
January 2003 Joshi, M.S.; Julian, M. W.; Crouser, E. D.; Bauer, J. A.."Cardiac dysfunction, mitochondrial ultrastructural injury, and NOS2 induction in a feline model of acute sepsis" . : A216
January 2004 Fahy, R. J.; Julian, M. W.; Knoell, D. L.; Crouser, E. D.."Relative to other vital organs, the lung is resistant to injury during the acute phase of bacterial sepsis" . : A635
January 2004 Joshi, M. S.; Julian, M. W.; Crouser, E. D.; Bauer, J. A.."Attenuation of left ventricular dysfunction in a feline model of acute sepsis by cyclosporin A: Relation to TLR4 induction, NOS2 induction and protein nitration" . : 342
January 2004 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Morales, J. E.."A proteomic analysis of liver mitochondria during acute endotoxemia" . : A635
January 2004 Crouser, E. D.; Cook, C. H.; Julian, M. W.; Huff, J. E.."Damage and depletion of mitochondria in the liver during sepsis" . : 58A
January 2004 Crouser, E. D.; Cook, C. H.; Julian, M. W.; Huff, J. E.."Hepatic mitochondrial damage, dysfunction and depletion in a murine model of subacute sepsis" . : A636
January 2004 Crouser, E. D.; Huff, J. E.; Julian, M. W.; Green-Church, K.."Altered mitochondrial protein expression in the liver during acute endotoxemia" . : A139
January 2004 Joshi, MS, Julia, MW, Crouser, ED, Bauer, JA."Cyclosporin A Prevents Left Ventricular Dysfunction in a Feline Model of Acute Sepsis: Relation to NOS2 Induction, Protein Nitration and Mitochondrial Injury." ..
January 2005 Crouser, E. D.; Julian, M. W.; Huff, J. E.; Struck, J.."Delayed protein release from liver mitochondria during acute sepsis" . : A521
January 2005 Crouser, E. D.; Julian, M. W.; Fahy, R. J.; Knoell, D. R.."The susceptibility to mitochondrial damage differs in vital organs during endotoxemia" . : 45
January 2006 Lucas, D. M.; Hussain, S. R. A.; Johnson, A. J.; Smith, L. L.; Wagner, A. J.; Allison, J. M.; Guster, S. E.; Lin, T. S.; Byrd, J. C.; Julian, M. W.; Crouser, E. D.; Grever, M. R.."Flavopiridol decreases Mcl-1 and initiates early mitochondrial damage in chronic lymphocytic leukemia (CLL) cells" . : 595A
January 2006 Crouser, E. D.; Eng, C.; Wewers, M. D.; Knox, K. S.; Huff, J. E.; Julian, M. W.; Gavrilin, M. A.."Stromal gene expression in mediastinal lymph nodes of sarcoidosis patients" . : A794
January 2007 Shao, G.; Julian, M. W.; Huff, J. E.; Wewers, M. D.; Shadel, G. S.; Crouser, E. D.."Highly purified high mobility group proteins do not directly activate peripheral blood monocytes" . : A447
January 2007 Crouser, E. D.; Huff, J. E.; Wewers, M. D.; Knox, K. S.; Ross, P.; Abbas, A.; Eng, C.."Analysis of lung gene expression in sarcoidosis and granulomatous infections" . : A185
January 2007 Knoell, D. L.; Julian, M. W.; Bao, S.; Huff, J. E.; Crouser, E. D.."Sepsis mortality is dramatically increased in zinc deficient mice" . : A437
January 2008 Pasadhika, S.; Crouser, E. D.; Harrington, C. A.; Choi, D.; Planck, S. R.; Smith, J. R.; Rosenbaum, J. T.."Microarray gene expression profile of peripheral blood from patients with Sarcoidosis implicates the transcription factor, STAT1" .
November 2008 Raveendran, R.; Hauswirth, D. W.; Crouser, E. D.; Fox, C. C.."Sarcoidosis patients with profound CD4 lymphopenia and opportunistic infections" Seattle.
November 2009 Erdal, S.; Clymer, B.; Crouser, E. D.."Developing CAD tools for measuring sarcoidosis: Leveraging existing data from a personalized health care perspective" Chicago.
November 2009 Erdal, S.; Catalyurek, U.; Krishnamurthy, A.; Kamal, J.; Crouser, E. D.; Clymer, B.."3D haralick texture analysis using CUDA" Chicago.
May 2009 Crouser, E. D.; Julian, M. W.; Shao, G.; Fox, C. C.; Hauswirth, D. W.; Jehn, J. J.; Lozanski, G.; Erdal, S.; Wewers, M. D.."Infliximab reverses peripheral CD4+ T cell depletion in lymphopenic Sarcoidosis patients" San Diego.
February 2009 Shao, G, Julian, MW, Tridandapani, S, Crouser, ED."Mitochondrial Transcription Factor A (TFAM) Promotes Plasmacytoid Dendritic Cell Activation via Receptor for Advanced Dlycation Endproducts (RAGE" ..
May 2010 Thacker, M.; Aguda, B.; Crouser, E. D.."In silico modeling of sarcoidosis granuloma formation implicates TNF alpha and regulatory T cells (Tregs) as critical therapeutic targets" New Orleans.
May 2010 Crouser, E. D.; Shao, G.; Julian, M. W.; Bao, S.."PI-3K is essential for plasmacytoid dendritic cell type I IFN responses to mitochondrial transcription factor A (TFAM) and CpG DNA" San Diego.
May 2010 Crouser, E. D.; Julian, M. W.; Shao, G.."Mitochondrial antigens are selectively recognized by TLR-2 in the context of cell necrosis" New Orleans.
April 2011 Shao G, Julian MW, Boa S, McCullers, Lai JP, MK, Knoell D, Crouser ED."Mitochondrial Protiens Promote Lung Epithelial Wound Closure via Formyl Peptide Receptors" ..
April 2011 Julian MW, Shao G, Bao S, Crouser ED."PI-3K is Essential for Plasmacytoid Dendtritic Cell Type I IFN Responses to Mitochondrial Danger Signals: Mitochondrial Transcription Factor A (TFAM) and CpG DNA" ..
May 2012 Leise, B, Watts, M, Crouser, E, Roy, S, Sen, C, Belknap, J."Use of Laser Capture Microdissection for the Assessment of Equine Laminar Basal Epithelial Cell Signaling in the Early Stages of Laminitis" ..
June 2012 Chang, H, Julian, M, Tran, T, Simonette, P, Billman, GE, Hamlin, R, Crouser, ED, Raman, SV."Modeling At-Risk Myocardium vs Irreversible Injury in Non-ST-Elevation Acute Coronary Syndrome" ..
May 2012 Teferra, RA, Chacey, M, Crouser, ED."Effective Therapy of Diaphragmatic Sarcoidosis with Adalimumab" San Francisco.
May 2013 Siddiqui, Y, Crouser, ED, Raman, SV."Myocardial Inflammation is Commonly Detected by Cardiac MRI in Critical Care Patients with Sepsis" /.
January 2013 Julian, MW, Shao, G, Vangundy, ZC, Papenfuss, TL, Crouser, ED."Mitochondrial Transcription Factor A (TFAM), A Danger Signal Released from Damaged Cells, Promotes an Innate Immune in Through RAGE and TLR9 Signaling Pathways" /.
January 2014 Julian, MW, Vangundy, ZC, Papenfuss, TL, Crouser, ED."Cross-Suppression of TLR4-and TLR9-Mediated Immune Responses in a Murine Splenocyte Culture Model" /.
May 2014 Crouser, ED, Wang, K, Nana-Sinkam, SP."Next Generation Sequencing Indetifies a Distinct Plasma Transcriptome Profile in Patients with Active Pulmonary Sarcoidosis" ..
Crouser, ED, Julian, MW, Strange, HR, Hotchkiss, RS, Ballinger, MN, Papenfuss, TL."TLR4- and TLR9- Mediated Immune Tolerance and Cross-Tolerance is Attenuated by IL-7 Treatment" .

Inventions and Patents

Crouser, ED. "Volumetric Texture Score (Lung texture score based on computerized lung CT scan analysis)." Filed May 2014.

 

Presentations

"Acid lung injury results in ileal endothelial injury, but not an abnormal VO2-DO2 relationship in the ileum." Presented at American Thoracic Society Meeting, San Francisco, CA. (May 1995)

"Update on Pulmonary Sarcoidosis." Presented at American Lung Association, Ohio Chapter, Columbus, OH. (April 1998)

"Update on Pulmonary Sarcoidosis." Presented at American Lung Association, Ohio Chapter, Columbus, OH. (April 1999)

"Induction of the permeability transition contributes to mitochondrial injury and altered respiration during endotoxemia." Presented at Frontiers of Mitochondrial Research Conference, Albany, NY. (September 2000)

"Monitoring Tissue Oxygenation and Other Bioenergetic Parameters During Cardiopulmonary Resuscitation." Presented at Post-Resuscitative and Initial Utility in Life Saving Efforts (PULSE) Workshop, Leesburg, VA. (June 2000)

"Sarcoidosis Update." Presented at The Ohio Thoracic Society, Columbus, OH. (February 2001)

"Sepsis-induced Organ Failure: The Role of the Mitochondrial Permeability Transition." Presented at Mitochondrial Interest Group (MIG) Teleconference, Columbus, OH. (March 2001)

"Inhibition of the permeability transition attenuates mitochondrial injury and normalizes mitochondrial respiration during endotoxemia." Presented at Mitochondrial Medicine Society Meeting, San Diego, CA. (March 2001)

"Damage and depletion of mitochondria in the liver during CLP sepsis." Presented at 6th World Congress in Trauma, Shock, Inflammation and Sepsis, Munich, DE|DEU. (March 2004)

"Consequences of the Mitochondrial Permeability Transition in Vital Organs During Acute Sepsis." Presented at 6th World Congress in Trauma, Shock, Inflammation and Sepsis, Munich, DE|DEU. (March 2004)

"Mechanisms of organ failure during sepsis." Presented at Ohio Thoracic Society Annual Meeting, Cambridge, OH. (September 2004)

"Genetically determined susceptibility to retained infectious agents in sarcoidosis patients”. (Invited speaker)." Presented at 3rd Annual National Academies Keck Futures Initiative Conference, Irvine, CA. (November 2005)

"Resonance between organ injury and inflammation during severe sepsis." Presented at American Thoracic Society Meeting, San Diego, CA. (May 2005)

"The susceptibility to mitochondrial damage differs in vital organs during sepsis." Presented at European Shock Society Meeting, Vienna, AT|AUT. (January 2005)

"Gauging Sarcoidosis Disease Activity." Presented at The Cleveland Clinic Foundation, Cleveland, OH. (August 2005)

"Apoptosis and Mitochondrial Permeability Transition Pores." Presented at 35th Critical Care Congress, San Francisco, CA. (January 2006)

"Sepsis and MODS: The Human Perspective." Presented at Havenmeyer Equine Conference, Myrtle Beach, South Carolina. (May 2007)

"Pathogenesis of Sepsis-Induced Organ Failures." Presented at Havenmeyer Equine Conference, Myrtle Beach, South Carolina. (May 2007)

"Induction of Inflammation by Mitochondrial Proteins." Presented at 36th Critical Care Congress, Orlando, FL. (February 2007)

"Exploring the Link between Mitochondria, Metabolism and MODS during Sepsis." Presented at American College of Veterinary Internal Medicine, San Antonio, Texas. (June 2008)

"Everything you wanted to know about Mitochondria but were afraid to ask." Presented at American Thoracic Society International Conference, Toronto, Canada. (May 2008)

"Sepsis and MODS: The Human Perspective." Presented at American College of Veterinary Internal Medicine, San Antonio, Texas. (June 2008)

"The role of microcirculatory disturbances in pathogenesis of sepsis-induced mutliple organ dysfunction." Presented at American Thoracic Society International Conference, San Diego, California. (May 2009)

"In Silico modeling of sarcoidosis granuloma formation implicates TNFa and regulatory T cells (Tregs) as critical therapeutic targets." Presented at American Thoracic Society International conference, Orleans, California. (May 2010)

"MicroRNA targets the neopterin pathway in pulmonary sarcoidosis." Presented at American Thoracic Society International meeting, Denver, Colorado. (May 2011)

"Normal Mitochondrial Function and Pathological Changes." Presented at Society of Critical Care Medicine (SCCM) Web Cast: The Pediatric O2 Series, Session 4: Turning Oxygen Into Energy., . (June 2012)

"Immune Cells are Critical Sensors of Mitochondrial Danger Signals." Presented at American Thoracic Society (ATS) Conference, . (May 2013)

"Fatal Inflammation Through TLR9 Signaling." Presented at American Transplant Congress Conference, Seattle, WA. (May 2013)

"Assessing Organ Involvement." Presented at The Cleveland Clinic Foundation, WASOG Meeting, 270 Participants, . (October 2013)

"Mitochondrial Transcription Factor A (TFAM), A Danger Signal Released from Damaged Cells, Promotes an Innate Immune in Through RAGE and TLR9 Signaling Pathways." Presented at Society of Critical Care Medicine (SCCM) Conference, 2013 Research Award Recipient, . (January 2013)

"Meet the Expert: Sarcoidosis Diagnosis and Treatment." Presented at American Thoracic Society (ATS) Conference, . (May 2013)

"Next Generation Sequencing Identifies a Distinct Plasma Transcriptome Profile in Patients with Active Pulmonary Sarcoidosis." Presented at American Thoracic Society (ATS) Conference, . (May 2014)

"Meet the Expert: Sarcoidosis Diagnosis and Treatment." Presented at American Thoracic Soicety (ATS) Conference, . (May 2014)

"PAMPs, DAMPs and Immune Physiology." Presented at Society of Critical Care Medicine Conference, . (January 2014)

"The Role of Hospitalists in the Care of ICU Patients." Presented at Society of Critical Care Medicine Conference, . (January 2015)

"Metabolic Alterations During Sepsis-Induced Organ Failures." Presented at Society of Critical Care Medicine Conference, . (January 2015)

"Applying Genomics to Advance Sarcoidosis Treatment: Opportunities and Challenges." Presented at National Jewish Health Conference, . (April 2015)

"Meet the Expert." Presented at American Thoracic Society (ATS) Conference/Foundation for Sarcoidosis Research, . (May 2015)

"Bioenergetics, Mitochondrial Dysfunction, and Oxidative Stress in Septic Encephalopathy." Presented at Society of Critical Care Medicine Conference, . (January 2015)

"Novel Therapies for Pulmonary Sarcoidosis." Presented at American Thoracic Society (ATS) Conference, . (May 2015)

 

Professional Activities

2003 - present Burroughs Wellcome Foundation.
2003 - present The Wellcome Trust (London), Ad Hoc Reviewer.
2004 - present American Lung Association (Ohio Chapter).
2006 - present Davis Heart & Lung Research Institute, Intramural Grants.
2006 - present American Thoracic Society. ATS Meeting.
2007 - present Mentorship of Postdoctoral Fellow. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine.
2013 - present Advisory Board Service. Beckman Coulter.
2013 - present Advisory Board Service. Bristol Meyer Squibb.
2015 - present Advisory Board Service. Mallinckrodt.
2008 Nationwide Children's/OSU Collaborative Grants Review.
2003 - 2009 Society of Critical Care Medicine, Vision Grants.
2005 - 2009 SCCM Meetings. Society for Critical Care Medicine.
2009 NIH- Special Emphasis Panels ZRG1 GGG- F(58) and ZRG1 CVRS-B(58)R.
2010 NIH- Surgery Anesthesiology and Trauma (SAT) Study Section, Ad Hoc.
2011 NIH- ZRG1 SBIB-Q (SAT).
2011 CCTS Intramural Grants- The Ohio State University.
2006 - 2012 Society of Critical Care Medicine (Vision Grants) Reviewer.
2012 KL2 Grant Review- The Ohio State University CCTS Program: 2012.
2014 German Federal Ministry for Education and Research (BMBF); Translational Consortia for Rare Diseases Research- Reviewer.
2013 - 2015 Advisory Board Service. Questcor.