Clay B. Marsh, MD
264 Meiling Hall
370 West 9th Avenue
Columbus, OH 43210
Phone: (614) 293-9309
Email: marsh.2@osu.edu
Current OSU Appointments
Assoc VP Health Sciences Rsch, Health Sciences Administration
Physician, FPG-Pulm-Allrgy-CritCare-Sleep
Professor, SBS-Molec Vir, Imm & Med Gen
Professor, Veterinary Biosciences
Vice Dean, ADM-Medicine Administration
Biographical Narrative
Clay Marsh, MD is Executive Director of the Center for Personalized Health Care and Vice Dean and Senior Associate Vice President for Research at the College of Medicine. He is also Professor of Internal Medicine in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine and is board certified in Pulmonary and Critical Care Medicine. He is the current director of the Center for Critical Care and Respiratory Medicine, one of six signature programs at OSU Medical Center, where he has implemented systems approaches to adherence to evidence-based guidelines to improve care delivery. He is cross-appointed in five basic science departments and graduate programs.
Dr. Marsh is focused at understanding deep biology underlying human health and disease and has a 17 year history of consecutive funding from NIH and regularly serves on NIH study sections. He leads the efforts in Personalized Health Care at The Ohio State University, where he and the senior leadership are leading the effort in transforming health care delivery by creating pilot programs in wellness and chronic disease testing disruptive solutions that result in lower cost and higher quality/outcomes. Under his direction, OSU is a partner in the Coriell Institute's Personalized Medicine Collaborative and led OSU's efforts in partnering with the Institute for Systems Biology to form the P4 Medicine Institute. He has been listed in America's Best Doctors© for each of the past 8 years. He has mentored over 50 MD, MD/PHD and PhD doctoral students, post-doctoral researchers and junior faculty.
Dr Marsh is a member of the board of directors for the Personalized Medicine Coalition and on the executive board of the Utah Personalized Medicine Summit. He is the former director of the scientific board and past Chair of the Board of Directors of the Stanley Sarnoff Foundation for Cardiovascular Medicine and is on the National Advisory Board for the Pulmonary Bioinitiative for Lung Health and Disease with Battelle Memorial Institute and the Institute for Systems Biology and is an elected member of the American Society for Clinical Investigation. Dr. Marsh has published over 100 papers in peer-reviewed journals and maintains an active laboratory and clinical practice at Ohio State University.
Certifications
| 1985 - present | Board Certification: Medical Examination, National Board of Medical Examiners |
| 1988 - present | Board Certification: Internal Medicine, American Board of Internal Medicine |
| 1993 - present | Board Certification: Pulmonary Medicine, American Board of Internal Medicine |
| 1994 - present | Board Certification: Critial Care Medicine, American Board of Internal Medicine |
Chapters In Books
Marsh CB, Mazzaferri E. 1993. In General Internal Medicine Pearls. Edited by S. Sahn, J. Heffner. Hanley and Belfus.
Marsh CB, Wewers MD. 1996. Immunopathogenesis of sepsis. In Clinics in Chest Medicine. Edited by P. Dorinsky. 183-197.
Wewers MD, Gadek JE, Marsh CB. 1996. Proinflammatory polypeptides. In The Lung: Scientific Foundations, 2nd Edition. Edited by Crystal RG and West JB. Lippencott-Raven.
Degrees
| 1981 | B.S., West Virginia University, Biology |
| 1985 | M.D., West Virginia University, Internal Medicine |
Editorial Activities
Ad Hoc Reviewer
| 2007 - present | Journal of Immunology, American Journal of Physiology, American Journal of Respiratory Cell and Molecular Biology. |
Associate Editor
| 1999 - present | Journal of Investigative Medicine. |
Honors
| Appointment to the Scientific Board of the Stanley J. Sarnoff Endowment for Cardiovascular Sciences. |
| Alpha Omega Alpha. |
| 1987 | Veterans Administration Service Award. |
| 1988 | Outstanding Medical Resident Award. |
| 1988 | Medical Student Teaching Award. |
| 1992 | American Federation of Clinical Research Trainee Investigator Award. |
| 1993 | James V. Warren Research Award. |
| 1997 - 1998 | Teacher of the Year Award. |
| 1998 - 1999 | Faculty of the Year. |
| 1999 - 2002 | Johnie Walker Murphy Career Investigator Award. |
| 2000 | Central Society for Clinical Research. |
| 2001 | Faculty Teaching Award. |
| 2001 | Faculty Mentor Award. |
| 2001 | Scientific Award. |
| 2002 - 2004 | Lung Biology and Pathology A. |
| 2002 - 2004 | Recipient. |
| 2003 | Presidential Award. |
| 2003 - 2007 | Study Section Member. |
| 2004 | Research Advocacy Board. |
| 2004 | Elected Member. |
| 2004 | Unverferth Research Award. |
| 2005 | America's Best Doctors. |
| 2005 | Faculty Research Award. |
| 2005 - 2006 | Chair Elect, Scientific Board. |
| 2007 | America's Best Doctors. |
Licensure
| 1989 - present | Medical License: State Medical Board of Ohio |
Memberships
| Member. Stanley J. Sarnoff Endowment for Cardiovascular Sciences. Scientific Board |
| 1989 - 2007 | Member. American Thoracic Society |
| 1989 - 2007 | Member. Ohio Thoracic Society |
| 1990 - 2007 | Member. American College of Physicians |
| 1993 - 2007 | Member. American Association for the Advancement of Science |
| 1994 - 2007 | Member. International Cytokine Society |
| 1994 - 2007 | Member. American Federation for Medical Research |
| 1995 - 2007 | Member. American Association of Immunologists |
| 1997 - 2007 | Member. Federation of American Society for Experimental Biology |
| 1998 - present | Member. American Federation for Medical Research. National Council |
| 1999 - present | Chair. American Thoracic Society, AAI Memership. Membership Committee |
| 1999 - 2000 | Member. AFMR/CSCR. Organizing Committe - Midwest Meeting |
| 1999 | Member. FASEB International Meeting. Oxident injury and signal transduction in the lung |
| 2000 - 2007 | Member. Central Society for Clinical Research |
| 2001 - present | Member. Sarnoff Scientific Endowment for Cardiovascular Sciences Board |
| 2002 | Member. National Institutes of Health Lung Bioology and Pathology A Study Section. Ad hoc, LBPA NIH |
| 2002 - present | Member. Sarnoff Scientific Board. Planning Committee |
| 2002 - 2004 | Chair. American Thoracic Society. AII Planning Committee |
| 2002 - 2007 | Member. American Society for Biochemistry and Molecular Biology |
| 2003 - 2005 | Member. LBPA Study Section. Lung injury, repair and remodeling secion |
| 2004 - 2007 | Member. American Society for Clinical Investigation |
| 2004 - present | Member. American Thoracic Society. Research Advocacy Group |
| 2004 - 2006 | Member. National Institutes of Health Lung Bioology and Pathology A Study Section. Ad hoc P01 Study Section |
| 2005 - 2006 | Member. Sarnoff Endowment for Cardiovascular Sciences Scientific Board |
| 2006 - 2007 | Chair. Sarnoff Endowment for Cardiovascular Sciences. Scientific Board |
| 2007 - present | Member. Battelle Biology and Health Scienc Initiative. External Advisory Board |
| 2007 - present | Member. Sarnoff Foundation for Cardiovascular Sciences |
| 2007 - present | Member. Society for Critical Care Medicine |
Peer Reviewed Journal Articles
Marsh, C B. 1978. Polymyositis leading to diagnosis and resection of occult localized carcinoma of the cecum. Southern medical journal. Vol. 71, no. 11: 1441-3.
George D, Marsh CB, Leier CV. 1988. The A Wave Liver. Clinical Cardiology. Vol. 11: 349-350.
Herzyk, D, J; Allen, J, N; Marsh, C, B; Wewers, M D. 1992. Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing. Journal of immunology (Baltimore, Md. : 1950). Vol. 149, no. 9: 3052-8.
Marsh, C, B; Mazzaferri, E L. 1994. Epigastric pain and weight loss in a middle-aged man. Hospital practice (Office ed.). Vol. 29, no. 12: 45.
Marsh, C, B; Mazzaferri, E L. 1994. Exertional dyspnea in a young woman. Hospital practice (Office ed.). Vol. 29, no. 11: 52-3.
Marsh, C, B; Mazzaferri, E L. 1994. Fever and diarrhea in a male college student. Hospital practice (Office ed.). Vol. 29, no. 9: 56.
Marsh, C, B; Mazzaferri, E L. 1994. Nephrotic syndrome, shoulder pain, and dyspnea in a persistent cougher. Hospital practice (Office ed.). Vol. 29, no. 10: 70-6, 79, 83 passim.
Marsh, C, B; Mazzaferri, E L. 1994. Shoulder and back pain with morning stiffness in an elderly woman. Hospital practice (Office ed.). Vol. 29, no. 8: 39.
Marsh, C, B; Moore, S, A; Pope, H, A; Wewers, M D. 1994. IL-1ra suppresses endotoxin-induced IL-1 beta and TNF-alpha release from mononuclear phagocytes. The American journal of physiology. Vol. 267, no. 1 Pt 1: L39-45.
Marsh, C, B; Pope, H, A; Wewers, M D. 1994. Fc gamma receptor cross-linking down-regulates IL-1 receptor antagonist and induces IL-1 beta in mononuclear phagocytes stimulated with endotoxin or Staphylococcus aureus. Journal of immunology (Baltimore, Md. : 1950). Vol. 152, no. 9: 4604-11.
Marsh, C, B; Trudeau, M, D; Weiland, J E. 1994. Recurrent asthma despite corticosteroid therapy in a 35-year-old woman. Chest. Vol. 105, no. 6: 1855-7.
Marsh, C, B; Wewers, M D. 1994. Cytokine-induced interleukin-1 receptor antagonist release in mononuclear phagocytes. American journal of respiratory cell and molecular biology. Vol. 10, no. 5: 521-5.
Allen, J, N; Moore, S, A; Pope-Harman, A, L; Marsh, C, B; Wewers, M D. 1995. Immunosuppressive properties of surfactant and plasma on alveolar macrophages. The Journal of laboratory and clinical medicine. Vol. 125, no. 3: 356-69.
Marsh, C, B; Gadek, J, E; Kindt, G, C; Moore, S, A; Wewers, M D. 1995. Monocyte Fc gamma receptor cross-linking induces IL-8 production. Journal of immunology (Baltimore, Md. : 1950). Vol. 155, no. 6: 3161-7.
Marsh, C, B; Mazzaferri, E L. 1995. Leg pain and numbness in an elderly man. Hospital practice (Office ed.). Vol. 30, no. 1: 59, 63.
Marsh, C, B; Mazzaferri, E L. 1995. Syncope in a middle-aged man at work. Hospital practice (Office ed.). Vol. 30, no. 3: 52.
Brown, E, A; Dare, H, A; Marsh, C, B; Wewers, M D. 1996. The combination of endotoxin and dexamethasone induces type II interleukin 1 receptor (IL-1r II) in monocytes: a comparison to interleukin 1 beta (IL-1 beta) and interleukin 1 receptor antagonist (IL-1ra). Cytokine. Vol. 8, no. 11: 828-36.
Marsh, C, B; Anderson, C, L; Lowe, M, P; Wewers, M D. 1996. Monocyte IL-8 release is induced by two independent Fc gamma R- mediated pathways. Journal of immunology (Baltimore, Md. : 1950). Vol. 157, no. 6: 2632-7.
Marsh, C, B; Wewers, M D. 1996. The pathogenesis of sepsis. Factors that modulate the response to gram-negative bacterial infection. Clinics in chest medicine. Vol. 17, no. 2: 183-97.
Pue, C, A; Mortensen, R, F; Marsh, C, B; Pope, H, A; Wewers, M D. 1996. Acute phase levels of C-reactive protein enhance IL-1 beta and IL-1ra production by human blood monocytes but inhibit IL-1 beta and IL-1ra production by alveolar macrophages. Journal of immunology (Baltimore, Md. : 1950). Vol. 156, no. 4: 1594-600.
Brown EA, Pope HA, Marsh CB, Wewers MD. 1997. LPS enhances type II receptor expression in dexamethosone treated macrophages: a comparison to IL-1 receptor antagonist. Cytokine. Vol. 8(11): 828-836.
Knoell DL, Marsh CB. 1997. Vocal Cord Dysfunction Presenting as Steroid-Dependent Asthma. Journal of Pharmacy Technology. Vol. 13: 118-121.
Marsh, C, B; Wewers, M, D; Tan, L, C; Rovin, B H. 1997. Fc(gamma) receptor cross-linking induces peripheral blood mononuclear cell monocyte chemoattractant protein-1 expression: role of lymphocyte Fc(gamma)RIII. Journal of immunology (Baltimore, Md. : 1950). Vol. 158, no. 3: 1078-84.
Ralston, D, R; Marsh, C, B; Lowe, M, P; Wewers, M D. 1997. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors. The Journal of clinical investigation. Vol. 100, no. 6: 1416-24.
Wewers, M, D; Marsh, C B. 1997. Role of the antibody in the pathogenesis of transplant vascular sclerosis: a hypothesis. Transplant immunology. Vol. 5, no. 4: 283-8.
Knoell, D, L; Pierson, J, F; Marsh, C, B; Allen, J, N; Pathak, D S. 1998. Measurement of outcomes in adults receiving pharmaceutical care in a comprehensive asthma outpatient clinic. Pharmacotherapy. Vol. 18, no. 6: 1365-74.
Marsh, C, B; Lowe, M, P; Rovin, B, H; Parker, J, M; Liao, Z; Knoell, D, L; Wewers, M D. 1998. Lymphocytes produce IL-1beta in response to Fcgamma receptor cross-linking: effects on parenchymal cell IL-8 release. Journal of immunology (Baltimore, Md. : 1950). Vol. 160, no. 8: 3942-8.
Kelley TW, Graham MM, Doseff A, Pomerantz RW, Lau SM, Ostrowski MC, Franke TW, Marsh CB. 1999. M-CSF Promotes Cell Survivsl Through Akt/protein kinase B. Journla of Biological Chemistry. Vol. 274: 26393-26398.
Kelley, T, W; Graham, M, M; Doseff, A, I; Pomerantz, R, W; Lau, S, M; Ostrowski, M, C; Franke, T, F; Marsh, C B. 1999. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. The Journal of biological chemistry. Vol. 274, no. 37: 26393-8.
Marsh, C, B; Pomerantz, R, P; Parker, J, M; Winnard, A, V; Mazzaferri, E L Jr; Moldovan, N; Kelley, T, W; Beck, E; Wewers, M D. 1999. Regulation of monocyte survival in vitro by deposited IgG: role of macrophage colony-stimulating factor. Journal of immunology (Baltimore, Md. : 1950). Vol. 162, no. 10: 6217-25.
Kelley TW, Graham MM, Marsh CB. 2001. The role of ROS in monocyte survival and TGF-B production. Chest. Vol. 120(1): 15S-16S.
Rovin, B, H; Lu, L; Marsh, C B. 2001. Lymphocytes induce monocyte chemoattractant protein-1 production by renal cells after Fc gamma receptor cross-linking: role of IL-1beta. Journal of leukocyte biology. Vol. 69, no. 3: 435-9.
Bhatt, Nitin, Y; Kelley, Todd, W; Khramtsov, Valery, V; Wang, Yijie; Lam, Gregory, K; Clanton, Thomas, L; Marsh, Clay B. 2002. Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes. Journal of immunology (Baltimore, Md. : 1950). Vol. 169, no. 11: 6427-34.
Coulter, Kristin, R; Doseff, Andrea; Sweeney, Patricia; Wang, Yijie; Marsh, Clay, B; Wewers, Mark, D; Knoell, Daren L. 2002. Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells. American journal of respiratory cell and molecular biology. Vol. 26, no. 1: 58-66.
Goyal, Anuj; Wang, Yijie; Graham, Mandy, M; Doseff, Andrea, I; Bhatt, Nitin, Y; Marsh, Clay B. 2002. Monocyte survival factors induce Akt activation and suppress caspase-3. American journal of respiratory cell and molecular biology. Vol. 26, no. 2: 224-30.
Tridandapani S, Wang Y, Marsh CB, Anderson CL. 2002. SH2 Domain Containing Inositol Polyphosphate Phosphatase (SHIP) Regulates NFkB-Mediated Gene Transcription by Phagocytic Fcy Receptors in Human Myeloid Cells. Journal of Immunology. Vol. 169(8): 4370-4378.
Tridandapani, Susheela; Wang, Yijie; Marsh, Clay, B; Anderson, Clark L. 2002. Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells. Journal of immunology (Baltimore, Md. : 1950). Vol. 169, no. 8: 4370-8.
Baran, Christopher, P; Tridandapani, Susheela; Helgason, Cheryl, D; Humphries, R Keith; Krystal, Gerald; Marsh, Clay B. 2003. The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. The Journal of biological chemistry. Vol. 278, no. 40: 38628-36.
Eubank, Tim, D; Galloway, Michelle; Montague, Christine, M; Waldman, W James; Marsh, Clay B. 2003. M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes. Journal of immunology (Baltimore, Md. : 1950). Vol. 171, no. 5: 2637-43.
Fahy, Ruairi, J; Lichtenberger, Frank; McKeegan, Christine, B; Nuovo, Gerard, J; Marsh, Clay, B; Wewers, Mark D. 2003. The acute respiratory distress syndrome: a role for transforming growth factor-beta 1. American journal of respiratory cell and molecular biology. Vol. 28, no. 4: 499-503.
Ganesan, Latha, P; Fang, Huiqing; Marsh, Clay, B; Tridandapani, Susheela. 2003. The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells. The Journal of biological chemistry. Vol. 278, no. 37: 35710-7.
Pengal, Ruma, A; Ganesan, Latha, P; Fang, Huiqing; Marsh, Clay, B; Anderson, Clark, L; Tridandapani, Susheela. 2003. SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. The Journal of biological chemistry. Vol. 278, no. 25: 22657-63.
Tridandapani, Susheela; Wardrop, Richard; Baran, Christopher, P; Wang, Yijie; Opalek, Judy, M; Caligiuri, Michael, A; Marsh, Clay B. 2003. TGF-beta 1 suppresses [correction of supresses] myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit. Journal of immunology (Baltimore, Md. : 1950). Vol. 170, no. 9: 4572-7.
Vasudevan, Sanjay, S; Lopes, Neuza H, M; Seshiah, Puvi, N; Wang, Tao; Marsh, Clay, B; Kereiakes, Dean, J; Dong, Chunming; Goldschmidt-Clermont, Pascal J. 2003. Mac-1 and Fas activities are concurrently required for execution of smooth muscle cell death by M-CSF-stimulated macrophages. Cardiovascular research. Vol. 59, no. 3: 723-33.
Zeigler, Mandy, M; Doseff, Andrea, I; Galloway, Michelle, F; Opalek, Judy, M; Nowicki, Philip, T; Zweier, Jay, L; Sen, Chandan, K; Marsh, Clay B. 2003. Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation. The Journal of biological chemistry. Vol. 278, no. 15: 12894-902.
Baran, Christopher, P; Zeigler, Mandy, M; Tridandapani, Susheela; Marsh, Clay B. 2004. The role of ROS and RNS in regulating life and death of blood monocytes. Current pharmaceutical design. Vol. 10, no. 8: 855-66.
Cao, Xianhua; Wei, Guo; Fang, Huiqing; Guo, Jianping; Weinstein, Michael; Marsh, Clay, B; Ostrowski, Michael, C; Tridandapani, Susheela. 2004. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. Journal of immunology (Baltimore, Md. : 1950). Vol. 172, no. 8: 4851-7.
Eubank, Tim, D; Roberts, Ryan; Galloway, Michelle; Wang, Yijie; Cohn, David, E; Marsh, Clay B. 2004. GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice. Immunity. Vol. 21, no. 6: 831-42.
Fang, Huiqing; Pengal, Ruma, A; Cao, Xianhua; Ganesan, Latha, P; Wewers, Mark, D; Marsh, Clay, B; Tridandapani, Susheela. 2004. Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. Journal of immunology (Baltimore, Md. : 1950). Vol. 173, no. 1: 360-6.
Jin, Ming; Opalek, Judy, M; Marsh, Clay, B; Wu, Haifeng M. 2004. Proteome comparison of alveolar macrophages with monocytes reveals distinct protein characteristics. American journal of respiratory cell and molecular biology. Vol. 31, no. 3: 322-9.
Wang, Yijie; Keogh, Rosemary, J; Hunter, Melissa, G; Mitchell, Christina, A; Frey, Randall, S; Javaid, Kamran; Malik, Asrar, B; Schurmans, Stephane; Tridandapani, Susheela; Marsh, Clay B. 2004. SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling. Journal of immunology (Baltimore, Md. : 1950). Vol. 173, no. 11: 6820-30.
Bao, Shenying; Wang, Yijie; Sweeney, Patricia; Chaudhuri, Alpana; Doseff, Andrea, I; Marsh, Clay, B; Knoell, Daren L. 2005. Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology. Vol. 288, no. 1: L36-42.
Massullo, Pam; Druhan, Lawrence, J; Bunnell, Bruce, A; Hunter, Melissa, G; Robinson, John, M; Marsh, Clay, B; Avalos, Belinda R. 2005. Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes. Blood. Vol. 105, no. 9: 3397-404.
Wu, Haifeng, M; Jin, Ming; Marsh, Clay B. 2005. Toward functional proteomics of alveolar macrophages. American journal of physiology. Lung cellular and molecular physiology. Vol. 288, no. 4: L585-95.
Ai J, Maturu A, Johnson W, Wang Y, Marsh CB, S Tridandapani. 2006. The inositol phosphatase SHIP-2 regulates FcyR-mediated phagocytosis in murine macrophages independently of SHIP-1. Blood. Vol. 107(2): 813-20.
Ai, Jing; Maturu, Amita; Johnson, Wesley; Wang, Yijie; Marsh, Clay, B; Tridandapani, Susheela. 2006. The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. Blood. Vol. 107, no. 2: 813-20.
Bhatt, Nitin; Baran, Christopher, P; Allen, James; Magro, Cynthia; Marsh, Clay B. 2006. Promising pharmacologic innovations in treating pulmonary fibrosis. Current opinion in pharmacology. Vol. 6, no. 3: 284-92.
Butchar, Jonathan, P; Parsa, Kishore V, L; Marsh, Clay, B; Tridandapani, Susheela. 2006. Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response. Current pharmaceutical design. Vol. 12, no. 32: 4143-53.
Jin M, Diaz PT, Bourgeois T, Eng C, Marsh CB, Wu H. 2006. Two-dimensional get proteome reference map of blood monocytes. Proteome Science. Vol. 1: 4-16.
Lichtenberger F, Frambach G, Montague CM, Marsh CB. 2006. NAC and DTT promote TGF-beta1 monomer formation: demonstrationof competitive binding. The Journal of Inflammation. Vol. 3: 7.
Magalang, Ulysses, J; Rajappan, Ramya; Hunter, Melissa, G; Kutala, Vijay, K; Kuppusamy, Periannan; Wewers, Mark, D; Marsh, Clay, B; Parinandi, Narasimham L. 2006. Adiponectin inhibits superoxide generation by human neutrophils. Antioxidants & redox signaling. Vol. 8, no. 11-12: 2179-86.
Magro, Cynthia, M; Waldman, W James; Knight, Deborah, A; Allen, James, N; Nadasdy, Tibor; Frambach, Gwyn, E; Ross, Patrick; Marsh, Clay B. 2006. Idiopathic pulmonary fibrosis related to endothelial injury and antiendothelial cell antibodies. Human immunology. Vol. 67, no. 4-5: 284-97.
Montague, Christine, R; Hunter, Melissa, G; Gavrilin, Mikhail, A; Phillips, Gary, S; Goldschmidt-Clermont, Pascal, J; Marsh, Clay B. 2006. Activation of estrogen receptor-alpha reduces aortic smooth muscle differentiation. Circulation research. Vol. 99, no. 5: 477-84.
O'Brien, James M Jr; Phillips, Gary, S; Ali, Naeem, A; Lucarelli, Maria; Marsh, Clay, B; Lemeshow, Stanley. 2006. Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Critical care medicine. Vol. 34, no. 3: 738-44.
Varadharaj, Saradhadevi; Steinhour, Emily; Hunter, Melissa, G; Watkins, Tonya; Baran, Christopher, P; Magalang, Ulysses; Kuppusamy, Periannan; Zweier, Jay, L; Marsh, Clay, B; Natarajan, Viswanathan; Parinandi, Narasimham L. 2006. Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases. Cellular signalling. Vol. 18, no. 9: 1396-407.
Yang, Eric, V; Sood, Anil, K; Chen, Min; Li, Yang; Eubank, Tim, D; Marsh, Clay, B; Jewell, Scott; Flavahan, Nicholas, A; Morrison, Carl; Yeh, Peir-En; Lemeshow, Stanley; Glaser, Ronald. 2006. Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer research. Vol. 66, no. 21: 10357-64.
Ali N, Lichtenberger F, Bickerstaff A, Flavahan N, Orosz CG, Marsh CB. 2007. LAP is Biologically Active and Regulates Inflammation via Interactions with Thrombospondin-1 and CD36 - REVISED Manuscript.
Fulci G, Dmitrieva N, Gianni D, Fontana E, Lu Y, Kaufman C, Kaur B, Lawler S. Lee R, Marsh C, Brat D, vanRooijen N, Rachamimov A, Hockberg F, Weissleder R, Martuza R, Chiocca EA. 2007. Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses - ACCEPTED. Cancer Research.
Hagele, Thomas, J; Mazerik, Jessica, N; Gregory, Anita; Kaufman, Bruce; Magalang, Ulysses; Kuppusamy, M Lakshmi; Marsh, Clay, B; Kuppusamy, Periannan; Parinandi, Narasimham L. 2007. Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress. International journal of toxicology. Vol. 26, no. 1: 57-69.
Hunter MG, Iltchev D, Marsh CBA. 2007. A soluble factor released by THP-1 monocytic cells in response to PMA and GM-CSF-stimulated monocytes influences cellular differentiation - IN PREPARATION.
Lichtenberg F, Marsh CB. 2007. Surfactant activates latent TGF-B: potential role in human lung disease - IN PREPARATION.
Mo X, guttridge D, Hunter MG, Marsh CB. 2007. MEK/Erk is critical in M-CSF-induced NF...IN PREPARATION.
O'Brien Jr JM, West T, Ali N, Smith R, Leasure J, Hoffmann S, Marsh C. 2007. The clinical Assessment Nurse (CAN) Program Improves Adherence to Recommended Critical Care Practices - SUBMITTED.
O'Brien, James M Jr; Lu, Bo; Ali, Naeem, A; Martin, Greg, S; Aberegg, Scott, K; Marsh, Clay, B; Lemeshow, Stanley; Douglas, Ivor S. 2007. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Critical care medicine. Vol. 35, no. 2: 345-50.
Opakek JM, Ali NA, Marsh CB. 2007. MCP-1 is a selective cheomattractant for blood monocytes - SUBMITTED.
Wang, Yijie; Zeigler, Mandy, M; Lam, Gregory, K; Hunter, Melissa, G; Eubank, Tim, D; Khramtsov, Valery, V; Tridandapani, Susheela; Sen, Chandan, K; Marsh, Clay B. 2007. The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. American journal of respiratory cell and molecular biology. Vol. 36, no. 1: 68-77.
Baran CP, Opalek JM, McMaken S, Newland CA, O'Brien Jr JM, Hunter MG, Bringardner BD, Monick MM, Brigstock DR, Stromberg PC, Hunninghade GW, Marsh CB. 2007. Important roles for M-CSF, CCL2 and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Medicine - Epub ahead of print. Vol. 176, no. 1. (July 1): 78-89. (IF: 9.091)
Positions
| 1985 - 1988 | Intern / Resident, The Ohio State University, Department of Internal Medicine Residency Program. Columbus, OH, United States. |
| 1988 - 1989 | Research Fellow, The Ohio State University, Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine. Columbus, OH, United States. |
| 1989 - 1990 | Chief Resident, The Ohio State University, Department of Internal Medicine Residency Program. Columbus, OH, United States. |
| 1990 - 1992 | Fellow, The Ohio State University, Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine. Columbus, OH, United States. |
| 1993 - 1995 | Instructor / Extension of Research Fellowship, The Ohio State University, Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine. Columbus, OH, United States. |
| 1995 - 1998 | Assistant Professor of Medicine, The Ohio State University, Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine. Columbus, OH, United States. |
| 1997 - 1998 | Counselor, American Federation for Medical Research, Midwest Section. |
| 1997 - 1998 | Assistant Professor , The Ohio State University, Internal Medicine . Columbus, OH, United States. |
| 1998 | Moderator and Speaker, American Federation for Medical Research, Midwest Section Meeting. Chicago, IL. |
| 1998 | Features Speaker, American College of Clinical Pharmacology, National Meeting. Cincinnati, OH. |
| 1998 - 1999 | President elect, American Federation for Medical Research, Midwest Section. |
| 1999 | Organizer and Speaker, American Thoracic Society, ATS International Meeting. San Diego, CA. |
| 1999 - 2000 | President, American Federation for Medical Research, Midwest Section. |
| 2000 | Speaker, Ohio State University - National Medical Scientist Student Forum, Post-M.D. fellowship training and academic medicine. Columbus, OH. |
| 2001 | Organizer and Speaker, International American Thoracic Society, International ATS Meeting. San Francisco, CA. |
| 1998 - 2002 | Associate Professor , The Ohio State University, Internal Medicine . Columbus, OH, United States. |
| 2002 - 2003 | Interim Director, The Ohio State University, Division of Pulmonary & Critical Care Medicine. Columbus, OH, United States. |
| 1998 - 2004 | Associate Professor of Medicine, The Ohio State University, Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine. Columbus, OH, United States. |
| 2000 - 2004 | Associate Director for Education and Research Initiiatives, The Ohio State University, Dorothy M. Davis Heart and Lung Research Institute. Columbus, OH, United States. |
| 2002 - 2004 | Associate Professor , The Ohio State University, Pulm,Allergy,Crit Care & Sleep . Columbus, OH, United States. |
| 1998 - 2007 | Investigator, The Ohio State University, The Dorothy M. Davis Heart and Lung Research Institute. Columbus, OH, United States. |
| 2000 - 2007 | Vice Chairman of Research, The Ohio State University, Department of Internal Medicine. Columbus, OH, United States. |
| 2000 - 2007 | Joint Appointment, The Ohio State University, Integrated Biomedical Science Graduat Program. Columbus, OH, United States. |
| 2000 - 2007 | Joint Appointment, The Ohio State University, Department of Pathology. Columbus, OH, United States. |
| 2000 - 2007 | Joint Appointment, The Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics. Columbus, OH, United States. |
| 2001 - 2007 | Joint Appointment, The Ohio State University, Department of Veterinary Sciences. Columbus, OH, United States. |
| 2001 - 2007 | Joint Appointment, The Ohio State University, The Ohio State University Biochemistry Program. Columbus, OH, United States. |
| 2003 - 2007 | Director, The Ohio State University, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine. Columbus, OH, United States. |
| 2004 - 2007 | Associate Director for Pulmonary Research, The Ohio State University, Dorothy M. Davis Heart and Lung Research Institute. Columbus, OH, United States. |
| 2004 - 2007 | Deputy Director, The Ohio State University, Dorothy M. Davis Heart and Lung Research Institute. Columbus, OH, United States. |
| 2005 - 2007 | Chair, The Ohio State University, Department of Internal Medicine, Signature Program in Critical Care Medicine. Columbus, OH, United States. |
| 2006 - 2007 | Chair, The Ohio State University, Department of Internal Medicine, Center for Critical Care. Columbus, OH, United States. |
| 2004 - 2009 | Professor , The Ohio State University, Pulm,Allergy,Crit Care & Sleep . Columbus, OH, United States. |
Presentations
Other Presentations
Local
Dr. Clay Braden Marsh. 1998. Apoptosis: Good News or Bad? Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (January 1)
Dr. Clay Braden Marsh. 1998. Update on Pulmonary Thromboembolic Disease. Presented at Pulmonary & Critical Care Review Course. Columbus, OH. (February 1)
Dr. Clay Braden Marsh. 1999. Monocyte survival and human diseases: the next Akt. Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (January 1)
Dr. Clay Braden Marsh. 1999. Update on new practives in the treatment of patients with asthma. Presented at Ohio State University East - Internal Medicine Grand Rounds. Columbus, OH. (January 1)
Dr. Clay Braden Marsh. 1999. Update on Interstitial Lung Disease. Presented at Pulmonary & Critical Care Review Course. Columbus, OH. (February 2)
Dr. Clay Braden Marsh. 2000. Update on community-acquired pneumonias. Presented at OSU Pulmonary and Critical Care Review Course. Columbus, OH. (February 1)
Dr. Clay Braden Marsh. 2000. Update on Pulmonary Fibrosis. Presented at OSU Pulmonary and Critical Care CME Course. Columbus, OH. (February 1)
Dr. Clay Braden Marsh. 2000. Monocyte survival in heart and lung disease: too much of a good thing. Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (May 1)
Dr. Clay Braden Marsh. 2000. Update on idiopathis pulmonary fibrosis. Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (July 1)
Dr. Clay Braden Marsh. 2000. Academic Medicine: road to the future. Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (August 1)
Dr. Clay Braden Marsh. 2000. The biochemical details of monocyte survival and differentiation: Roles in health and disease. Presented at Molecular Virology, Immunology and Human Genetics Seminar. Columbus, OH. (August 1)
Dr. Clay Braden Marsh. 2000. Life and death of the monocyte and impact on human disease. Presented at Ohio State University, Landacre Dinner Presentation. Columbus, OH. (September 1)
Dr. Clay Braden Marsh. 2000. Details of intracellular mechanisms of monocyte survival and differentiation. Presented at Ohio State University, Department of Physiology and Cellular Biology. Columbus, OH. (October 1)
Dr. Clay Braden Marsh. 2000. Life, Death and Differentiation of Monocytes. Presented at Ohio State University, Immunology Conference. Columbus, OH. (October 1)
Dr. Clay Braden Marsh. 2001. Life and death decisions of monocytes - implications for cancer and inflammation. Presented at Molecular Therapeutics Group. Columbus, OH. (March 1)
Dr. Clay Braden Marsh. 2001. Regulation of monocyte survival by nitric oxide. Presented at Davis Heart and Lung Research Institute. Columbus, OH. (March 1)
Dr. Clay Braden Marsh. 2001. Update on Asthma. Presented at Medical Therapeutics 2001. Columbus, OH. (March 1)
Dr. Clay Braden Marsh. 2001. Pulmonary Fibrosis: The Clinic Meets the Lab. Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (September 1)
Dr. Clay Braden Marsh. 2001. the rold of monocytes in regulating fibrosis in the lung: implications for treatment of IPF. Presented at Ohio State University, Veterinary Biosciences Seminar Series. Columbus, OH. (September 1)
Dr. Clay Braden Marsh. 2001. Discussant unknown case of SLE/anti-phospholipid. Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (November 1)
Dr. Clay Braden Marsh. 2002. Update on Pulmonary Embolism. Presented at OSU Pulmonary and Critical Care CME Course. Columbus, OH. (February 1)
Dr. Clay Braden Marsh. 2002. Update on Asthma. Presented at Medical Therapeutics 2002. Columbus, OH. (March 1)
Dr. Clay Braden Marsh. 2002. International Wound Healing and Oxygen Treatment, The Clinic Meets the Lab. Presented at Ohio State University - Internal Medicine Grand Rounds. Columbus, OH. (September 1)
Dr. Clay Braden Marsh. 2002. IGBP Featured Research Talk: The role of SHIP in the regulation of monocyte activation. Presented at Ohio State University. Columbus, OH. (October 1)
Dr. Clay Braden Marsh. 2002. New paradigms for the activation of TGF-B. Presented at Immunology Conference. Columbus, OH. (October 1)
Dr. Clay Braden Marsh. 2003. Update on Pulmonary Embolus. Presented at Pulmonary & Critical Care Medicine Update 2003. Columbus, OH. (February 1)
Dr. Clay Braden Marsh. 2003. Update on Asthma. Presented at Medical Therapeutics 2003. Columbus, OH. (March 1)
Dr. Clay Braden Marsh. 2004. New paradigms in pulmonary fibrosis. Presented at Davis Heart and Lung Research Institute Conference. Columbus, OH. (July 1)
Dr. Clay Braden Marsh. 2005. Adaptive immunity and immunological memory. Presented at Department of Molecular Virology, Immunolgy and Human Genetics. Columbus, OH. (February 1)
Dr. Clay Braden Marsh. 2005. M-CSF as a modulator of lung injury and repair. Presented at IGBP Seminar Series. Columbus. (March 1)
Dr. Clay Braden Marsh. 2005. The role of M-CSF in human health and disease. Presented at Pathology Grand Rounds. Columbus, OH. (March 1)
Dr. Clay Braden Marsh. 2005. Pearls in writing NIH grants. Presented at Davis Heart and Lung Research Institute Review Course. Columbus, OH. (November 1)
Dr. Clay Braden Marsh. 2006. How to get a K grant. Presented at Davis Heart and Lung Research Institute Review Course. Columbus, OH. (March 1)
Dr. Clay Braden Marsh. 2006. Sepsis. Presented at Ohio State University, Klassen Research Day. Columbus, OH. (June 9)
Dr. Clay Braden Marsh. 2007. Location, Location, Location: The Role of the Environment in Macrophage Function. Presented at Davis Heart and Lung Research Institute Retreat. Columbus, OH. (April 25)
