Beth Besecker, MD

Current OSU Appointments

Assistant Professor, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

Biographical

Dr. Beth Besecker is Assistant Professor of Internal Medicine on the tenure research track. She graduated Magna Cum Laude from The University of Toledo with a degree in Chemistry in three years. She obtained her medical degree from the Medical College of Ohio in Toledo and completed her Internal Medicine residency at Riverside Methodist Hospital in Columbus, Ohio. Dr. Besecker then completed her fellowship in Pulmonary and Critical Care Medicine at The Ohio State University in 2007. Dr. Besecker's research interests involve studying nutritional impact on monocyte/macrophage phagocytosis as it relates to systemic bacterial clearance and sepsis. She is currently funded with an NIH KL2 grant from the Center for Clincal and Translational Science to support her translational work in Innate Immune Cell Phagocytosis. She has presented her work at international meetings and has served on several American Thoracic Society committees.

Published Works

I have now published work related to zinc metabolism and its relationship to infection in a cell line model, mouse model and human subjects. I continue to pursue this line of investigational research in a translational manner.

Research Funding

I am currently funded by NIH CCTS KL2 Program (01/11-12/12).

Chapters in Books

Knoell DL and Besecker BY. "Zinc in Critical Illness and Sepsis." In Zinc in Human Health. Edited by Lothar Rink. -. January 0.

Journal Articles

Fahy RJ; Exline MC; Gavrilin MA; Bhatt NY; Besecker BY; Sarkar A; Hollyfield JL; Duncan MD; Nagaraja HN; Knatz NL; Hall M; Wewers MD. "Inflammasome mRNA expression in human monocytes during early septic shock.." American Journal Of Respiratory And Critical Care Medicine. Vol. 177, no. 9. (May 2008.): 983-.

Besecker B; Bao S; Bohacova B; Papp A; Sadee W; Knoell DL. "The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.." American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 294, no. 6. (June 2008.): L1127-.

Knoell DL; Julian MW; Bao S; Besecker B; Macre JE; Leikauf GD; DiSilvestro RA; Crouser ED. "Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis.." Critical Care Medicine. Vol. 37, no. 4. (April 2009.): 1380-.

Bao S; Liu MJ; Lee B; Besecker B; Lai JP; Guttridge DC; Knoell DL. "Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB.." American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 298, no. 6. (June 2010.): L744-.

Besecker,Beth,Y; Exline,Matthew,C; Hollyfield,Jennifer; Phillips,Gary; DiSilvestro,Robert,A; Wewers,Mark,D; Knoell,Daren,L. "A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission." AMERICAN JOURNAL OF CLINICAL NUTRITION. Vol. 93, no. 6. (June 2011.): 1356-1364.

Cremer TJ, Fatehchand K, Shah P, Gillette D, Patel H, Marsh RL, Besecker BY, Rajaram MV, Cormet-Boyaka E, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani S.. "MiR-155 Induction by Microbes/Microbial Ligands Requires NF-κB-Dependent de novo Protein Synthesis.." Front Cell Infect Microbiol.. Vol. 2, no. 73. (June 2012.): Epub-.

Reference Works

January 2002	Beth Besecker, MD."Three Strikes: Kidneys Out" .
January 2005	Beth Besecker, MD."Clinical and Financial Analysis of the Impletation of a Sedation Minimization Protocol in the ICU" .
January 2005	Beth Besecker, MD."Intrapleural Alteplase for the Complicated Parapneumonic Effusion" .
January 2006	Beth Besecker, MD."The Role of Cis-Acting Genetic Regulation on the Human Zinc Transporter SLC39A8-" .
January 2006	Beth Besecker, MD."Modulation of Zinc Thrasporter RNA Expression by TNFa in Human Lung Epithelia" .
January 2007	Beth Besecker, MD."Sepsis Mortality Is Dramatically Increased in Zinc Deficient Mice" .
January 2007	Beth Besecker, MD."Zinc Transporter SLC39A8 Is Critical in the Lung Epithelial Cell Response to Infalmmatory Stress" .
January 2008	Matt Exline, Beth Besecker, Jen Hollyfienld, R Fahy, Mark Wewers."Inflammasome mRA Expression in Critical-Ill Patients" .
January 2008	Beth Besecker, Matt Exline, Jen Hollyfield, Elizabeth Josephs, Robert DiSilvesro, Daren Knoell."Modulation of Zinc Homeostasis via Zinc Transporters in Humns with Sepsis" .
January 2009	Bao S, Liu M, Lee B, Besecker B, Guttridge D, Knoell D."Activation of NF-kB Contributes to Zinc-Deficiency-Enhanced Inflammation" .
January 2009	Besecker B, Knoell D."Zinc Status Impacts Murine Polymicrobial Sepsis Outcomes" .
January 2010	Exline M, Sarkar A, Besecker B, Hollyfield J, Mitra S, Wewers M."Inflammasome Constituets Released Via Microvesiles During Sepsis" .

Presentations

"Unknown Case Presentation: Endobrochial Hamartoma." Presented at The Ohio State University, Pulmonary and Critcal Care Medicine Division, . (March 2005)

"Interpretation of Arterial Blood Gases." Presented at Medical Student Second Year Curriculum, . (January 2006)

"X-Ray Interpretation of Spinal Injuries." Presented at ATLS Student Curriculum, . (January 2008)

"The Role of Zinc in Sepsis Survival." Presented at Annual Pulmonary Research Day 2008, . (January 2008)

"Pediatric and Elderly Trauma." Presented at ATLS Student Curriculum, . (January 2008)

"Interprettion of PFTs: Lung Volumes and DLCO." Presented at Fellowship Pulmonary Medical School Curriculum, . (January 2008)

"Ethics in Critcal Care Medicine." Presented at FCCS Course, The Ohio State University, . (January 2008)

"Management of Refractoy Hypoxemia: HFOV and Surfactant." Presented at Multidisciplinary Advances in the Treatment of the Critical Ill Hospitalized Patient Conference (MATCH), . (September 2009)

"Special ICU Considerations." Presented at FCCS Course, The Ohio State University, . (January 2009)

"Interpretaion of CXRs." Presented at Medical Student Third Year Curriculum, The Ohio State University, . (January 2009)

"COPD and Plueral Disease." Presented at Medical Student Second Year Curriculum, The Ohio State University, . (January 2009)

"Acute Respiratory Failure." Presented at FCCS Course, The Ohio State University, . (January 2009)

"An Unusual Case of Daytime Sleepines." Presented at Sleep Fellowship Case Conference, . (June 2009)

"Micronutrients in Critical Illness." Presented at Fellowship Curriculum Lecture, . (May 2010)

"Spine and Spinal Cord Trauma." Presented at ATLS Student Curriculum, . (February 2010)

"Mini-Symposium, ATS National Meeting." Presented at Co-Chair, . (May 2010)

"Micronutrients in Critical Illness." Presented at ATS International Conference: Sunrise Seminar, . (May 2010)

"Post-Op Cardiac ICU Care." Presented at Fellowship Pulmonary Medical School Curriculum, . (January 2010)

"Interpretation of CXRs." Presented at Medical Student Third Year Curriculum, The Ohio State University, . (January 2010)

"Interpretation of CXRs." Presented at Medical Student Third Year Curriculum, The Ohio State University, . (January 2010)