473 W 12th Ave
Columbus, OH 43210
Phone: (614) 293-4925
Assistant Professor, Pulm,Allergy,Crit Care & Sleep
I was hired as an Assistant Professor of Internal Medicine in January of 2009, on the tenure track. I graduated Magna Cum Laude from The University of Toledo with a degree in Chemistry in three years. My medical degree was obtained from the Medical College of Ohio in Toledo and I completed my Internal Medicine residency at Riverside Methodist Hospital in Columbus, Ohio. I then completed my fellowship in Pulmonary and Critical Care Medicine at The Ohio State University in 2007. I hold four board certifications in: Internal Medicine, Pulmonary Medicine, Critical Care Medicine, and Sleep Medicine.
Research (Publications and Grants): My research interests involve studying the impact of nutrition, in particular micronutrients, on monocyte/macrophage phagocytosis as it relates to bacterial clearance and inflammation in sepsis. In addition, I have established a track record of funding with an NIH F32 training grant, an NIH Center for Clinical and Translational Sciences (CCTS) KL2 mentored award, and most recently on NIH K23 mentored award. I have my own independent laboratory and IACUC/IRB protocols and currently perform basic, murine, and clinical studies related to my recently funded (09/13) NIH K23 award. The award entitled, “The Impact of Zinc on Innate Immunity and Patient Safety in Sepsis” supports my translational work in this area (mentored by Dr. Larry Schlesinger). I currently have over 12 published abstracts and 7 peer-reviewed, published manuscripts (plus one manuscript pending review). I was, also, recently asked to author a chapter on zinc in critical illness for a comprehensive ICU nutrition book. In addition, I am the OSU site-PI for TOP UP, an international, multi-site, nutrition clinical trial.
Teaching: I am involved in teaching students, residents, and fellows through didactic lectures, as an evaluator/preceptor for clinically related courses, and during teaching rounds while on clinical service. I'm also a preceptor for students and residents in my outpatient sleep clinic. I have consistently scored above average in my teaching evaluations, and my CXR lecture for the third year medical students has received excellent evaluations. I have taught pulmonary/critical care didactic lectures for second year medical students and have been a preceptor for the Introduction to Clinical Medicine Course. Lastly, I am involved at a regional level in teaching residents and peers by being an Advanced Trauma Life Support Instructor (ATLS), teaching sessions for the Fundamentals of Critical Care Support (FCCS) Course, and the annual Multidisciplinary Advances in the Treatment of Critically ill Hospitalized patients (MATCH).
Service/National Role: Locally, I've served as both a residency and fellowship interviewer and have given my time to mentor medical students as both a Learning Community Group Leader and now as a Portfolio Coach. Internationally, I have served on both the Planning and Membership Committees for Allergy, Immunology, and Inflammation (AII) (an Assembly of The American Thoracic Society) (2009-current). These committees have been responsible for programing the International Meeting and for developing and supporting a mentorship program for assembly members. I have just recently become chair of a sub-committee that will plan and execute the annual awards banquet. I am also an ad hoc reviewer for several well respected peer-reviewed manuscripts including Chest and Critical Care Medicine.
I have been recognized for my work as an invited lecturer and thematic poster facilitator at The American Thoracic Society International Meeting and the Nutrition and Rehabilitation Investigator’s Consortium (NUTRIC) International Meeting.
I have now published work related to zinc metabolism and its relationship to infection in a cell line model, mouse model and human subjects. I continue to pursue this line of investigational research in a translational manner.
I am currently funded by NIH K23 Program (09/13-08/17).
|2013 - present||The Ohio State University.|
|2002 - 2003||Riverside Methodist Hospital.|
|2011 - 2012||Joanna Daigle, The Ohio State University.|
|2009 - 2013||The Ohio State University.|
|2001 - present||Certification: American Heart Association|
|2001 - present||Certification: American Heart Association|
|2004 - present||Medical License: State Medical Board of Ohio|
|2004 - present||Board Certification: American Board of Internal Medicine|
|2006 - present||Board Certification: American Board of Internal Medicine|
|2007 - present||American Board of Internal Medicine: American Board of Internal Medicine|
|2011 - present||Board Certified Sleep Medicine: American Board of Internal Medicine|
Knoell DL and Besecker BY. "Zinc in Critical Illness and Sepsis." In Zinc in Human Health. 1st ed. Edited by Lothar Rink. 254-267. Amsterdam, NL|NLD: IOS Press, January 2011.
Besecker, B.Y.. "Dietary and Nutritional Aspects of Zinc in the Critically Ill Adult Patient." In Diet and Nutrition in Critical Care. Edited by Rajendram,R, Preedy,VK, Patel,VB. -.
|01/01/2009||Pulmonary Consults, ICU and Outpatient Clinic (OSU Hospitals (Main and East) and Clinic)|
|1998||B.A., University of Toledo|
|2001||M.D., Medical College of Ohio|
|2008 - present||SCCM National Conference|
|2009 - present||CHEST|
|2010 - present||ATS Web Cases|
|2012 - present||Molecular Nutrition and Food Research|
|2012 - present||Critical Care Medicine|
|2004||Research Citation Finalist, Poster Abstract. Society of Critical Care Medicine.|
|2007 - 2009||Zinc Importer SLC39A8 and Lung Epithelial Cell Survival. NIH NRSA.|
|2009 - 2011||Fellow. Center for Clinical and Translational Science.|
Fahy RJ; Exline MC; Gavrilin MA; Bhatt NY; Besecker BY; Sarkar A; Hollyfield JL; Duncan MD; Nagaraja HN; Knatz NL; Hall M; Wewers MD. "Inflammasome mRNA expression in human monocytes during early septic shock.." American Journal Of Respiratory And Critical Care Medicine. Vol. 177, no. 9. (May 2008.): 983-.
Besecker B; Bao S; Bohacova B; Papp A; Sadee W; Knoell DL. "The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.." American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 294, no. 6. (June 2008.): L1127-.
Knoell DL; Julian MW; Bao S; Besecker B; Macre JE; Leikauf GD; DiSilvestro RA; Crouser ED. "Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis.." Critical Care Medicine. Vol. 37, no. 4. (April 2009.): 1380-.
Bao S; Liu MJ; Lee B; Besecker B; Lai JP; Guttridge DC; Knoell DL. "Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB.." American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 298, no. 6. (June 2010.): L744-.
Besecker,Beth,Y; Exline,Matthew,C; Hollyfield,Jennifer; Phillips,Gary; DiSilvestro,Robert,A; Wewers,Mark,D; Knoell,Daren,L. "A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission." AMERICAN JOURNAL OF CLINICAL NUTRITION. Vol. 93, no. 6. (June 2011.): 1356-1364.
Cremer TJ, Fatehchand K, Shah P, Gillette D, Patel H, Marsh RL, Besecker BY, Rajaram MV, Cormet-Boyaka E, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani S.. "MiR-155 Induction by Microbes/Microbial Ligands Requires NF-κB-Dependent de novo Protein Synthesis.." Front Cell Infect Microbiol.. Vol. 2, no. 73. (June 2012.): Epub-.
Gillette DD, Shah PA, Cremer TA, Gavrilin MA, Besecker BY, Sarkar A, Knoell DL, Cormet-Boyaka E, Wewers MD, Butchar JP, Tridandipani S. "Analysis of human bronchial epithelial cell pro-inflammatory response to Burkholderia cenocepacia infection: Inability to secrete IL-1B." J Biol Chem. Vol. 288, no. 6. (February 2013.): 2691-5.
|January 2002||Beth Besecker, MD."Three Strikes: Kidneys Out" .|
|January 2005||Beth Besecker, MD."Clinical and Financial Analysis of the Impletation of a Sedation Minimization Protocol in the ICU" .|
|January 2005||Beth Besecker, MD."Intrapleural Alteplase for the Complicated Parapneumonic Effusion" .|
|January 2006||Beth Besecker, MD."The Role of Cis-Acting Genetic Regulation on the Human Zinc Transporter SLC39A8-" .|
|May 2006||Besecker, B, Bao,S, Bohacova,B, et. al.."Modulation of Zinc Transporter RNA Expression by TNFa in Human Lung Epithelia" New York. : A425|
|May 2007||Beth Besecker, Shengying Bao, Daren Knoell."Zinc Transporter SLC39A8 is Critical in Lung Epithelial Cell Response to Inflammatory Stress" New York. : A394|
|May 2007||Knoell,D, Julian,M, Bao, S, Besecker, B, Huff, J, Crouser, E."Sepsis Mortality Is Dramatically Increased in Zinc Deficient Mice" New York.|
|May 2008||Matt Exline, Beth Besecker, Jen Hollyfienld, R Fahy, Mark Wewers."Inflammasome mRNA Expression in Critically-Ill Patients" New York. : A123|
|May 2008||Beth Besecker, Matt Exline, Jen Hollyfield, Elizabeth Josephs, Robert DiSilvesro, Daren Knoell."Modulation of Zinc Homeostasis via Zinc Transporters in Humans with Sepsis" .. : A120|
|May 2008||Bao S, Besecker B, Bohacova B, Papp A, Sadee W, Knoell D."The Human Zinc Transporter Zip8 Is Essential in Lung Epithelia Cytoprotection" New York. : A473|
|May 2009||Besecker B, Knoell D."Zinc Status Impacts Murine Polymicrobial Sepsis Outcomes" .. : A1161|
|May 2009||Bao S, Liu M, Lee B, Besecker B, Guttridge D, Knoell D."Activation of NF-kB Contributes to Zinc-Deficiency-Enhanced Inflammation" .. : A1141|
|May 2010||Exline M, Sarkar A, Besecker B, Hollyfield J, Mitra S, Wewers M."Inflammasome Constituents Released Via Microvesicles During Sepsis" .. : A1378|
|May 2011||Besecker BY, Zakharova E, Mehta P, Tridandapani S."Zinc Status Impacts Fc Receptor Mediated Bacterial Phagocytosis in Human Monocytes" .. : A4535|
|May 2011||Exline MC, Hollyfield Jl, Besecker BY, O'Brien JM, Ali NA, Gavrilin MA, Wewers MD."Pathogen Sensor NLRP3 Suppressed During Sepsis and Improves During Recovery" .. : A2889|
|May 2012||Exline MC, Hollyfield, Besecker BY, Ali N, O'Brien J, Wewers MD."NOD1 and NOD2 Message Suppressed in Septic Patient Monocytes" .. : A5764|
|May 2012||Besecker BY, Zakharova E, Hollyfield JL, Exline MC."Sepsis Outcomes May Improve in Patients with Improved Plasma Zinc Concentration ICU Day Five" .. : A5765|
|May 2013||Besecker BY, Kochik S, Tridandipani S, Schlesinger L."Zinc Status Impacts Complement Receptor-Mediated Bacterial Phagocytosis in Human Macrophages" .. : A1318|
|May 2013||Exline MC, Justiniano SE, Hollyfield J, Besecker BY, Ali NA, Mitra S, Wewers MD, Sarkar A."Sepsis Triggers Release of Microvesicles Containing Caspase-1 In Active Form" .. : A2786|
"Management of Refractoy Hypoxemia: HFOV and Surfactant." Presented at Multidisciplinary Advances in the Treatment of the Critical Ill Hospitalized Patient Conference (MATCH), Columbus, Ohio. (September 2009)
"Ventilator Liberation." Presented at MATCH-Multidisciplinary Advances in the Treatment of the Critically Ill Patient, Columbus, Ohio. (September 2010)
"Mini-Symposium, ATS International Meeting." Presented at Co-Chair, California. (May 2010)
"Micronutrients in Critical Illness." Presented at ATS International Conference: Sunrise Seminar, California. (May 2010)
"Zinc Supplementation in Critically Ill Septic Patients." Presented at Nutric Meeting, Montreal, CA|CAN. (June 2012)
"Surviving Sepsis Campaign Guidelines-A Review." Presented at MATCH-Multidisciplinary Advances in the Treatment of the Critically Ill Patient, Columbus, Ohio. (September 2012)
"Immunologic Impact of Zinc Status During Sepsis." Presented at CMIB Annual Retreat, Columbus, OH. (April 2013)
|present||Poster Symposium. ATS International Meeting.|
|2007 - present||OSUMC Research Day. OSU Medical Center.|
|2007 - present||Resident Applicant Interviews. OSU Medical Center, Department of Internal Medicine.|
|2008 - present||Annual Pulmonary Research Day. OSU Medical Center.|
|2010 - present||Resident Applicant Interviews. OSU Medical Center, Department of Internal Medicine.|
|2012 - present||Resident Applicant Interviews. OSU Medical Center, Department of Internal Medicine.|
|2009 - 2012||Fellowship Applicant Interviewer.|
Matthew Exline, Steven Justiniano, Jeffifer Hollyfield, Freweine Berhe, Beth Besecker, Srabani Mitra, Mark D. Wewers, Anasuya Sarkar. Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis In Sepsis. August 2013.