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Andrea Doseff, PhD


Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-8987

Email: doseff.1@osu.edu

 

Current OSU Appointments

Associate Professor, Molecular Genetics Admin

Associate Professor, SBS-Physiology & Cell Biology

 

Biographical

Andrea I. Doseff, Ph.D. is an Associate Professor with tenure in the Department of Molecular Genetics (75%) and the Department of Physiology and Cell Biology (25%) at The Ohio State University. Dr. Doseff received her bachelor’s degree from University of Sciences of Buenos Aires, Argentina and her PhD from Cold Spring Harbor Laboratory, New York working in cell cycle regulation. She completed her postdoctoral training in apoptosis at Cold Spring Harbor Laboratory. She joined The Ohio State University as an Assistant Professor in 2002. She leads a multidisciplinary research team recognized nationally and internationally in the area of cell death and health-related mechanisms of flavonoids. Her findings have been published in PNAS, Immunity, Genetics, Journal of Biological Chemistry, Biochemical Pharmacology, and Journal of Immunology among others. She serves as Associate Editor and ad-hoc reviewer for several journals. She has received funding continuously from National Institute of Health, National Science Foundation, USDA, The American Lung Association and The American Heart Association. She serves as grant reviewer chair for American Heart Association and as ad-hoc for NSF and NIH. She teaches and has developed courses for undergraduate and graduate students. She is the co-Director of the Dual PhD Program OSU-University of São Paulo, Brazil and directs the SiGuE (Success in Graduate Education), post-baccalaureate program.

Advising Narrative

i) Fellowships Awarded to my Undergraduate Students (14 since my last promotion)



Arts and Sciences Research Fellowship 2014-2015

Shao, Q. (student) Doseff, A.I. (Mentor)

Total Award: $2,000



Arts and Sciences - Thomas Byers Memorial Fellowship 2013-2014

Rice, E. (student) Doseff, A.I. (Mentor)

Total Award: $2,000



Comprehensive Cancer Center-Pelotonia undergraduate fellowship 2012-2013

Tossey, J. (student) Doseff, A.I. (Mentor)

Title: The role of flavones in Hsp27-regulated apoptosis in non-small cell lung carcinomas

Total Award: $14,000



Arts and Sciences Honor Undergraduate Research Scholarship 2011-2012

Tossey, J. (student) Doseff, A.I. (Mentor)

Title: Regulation of cell death by the small heat shock protein 27

Total Award: $7,000



American Heart Association Undergraduate Fellowship Summer 2011

Tossey, J. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of the anti-apoptotic heat shock protein 27 in doxorubicin-induced cardiomyocyte Apoptosis

Total Award: $4,000



Undergraduate Student Government Academic Enrichment Grant, Travel Award April 2012

Tossey, J. (student) Doseff, A.I. (Mentor)

Total Award: $1,000 to attend the Experimental Biology Meeting



Pressey Honors Grant

Competitive award provides funds to attend a conference. Experimental Biology 2012

Tossey, J. (student) Doseff, A.I. (Mentor)

Total Award: $300



Sharp undergraduate scholarship 2009

Kamran, H. (student) Doseff, A.I. (Mentor)

Total Award: $1,000



The Mayers Summer Research Internship Award Summer 2009

Kamran, H. (student) Doseff, A.I. (Mentor)

Title: Molecular regulation of caspase-3

Total Award: $4,000



The Mayers Summer Research Internship Award Summer 2008

Murnan, E. (student) Doseff, A.I. (Mentor)

Title: Role of heat shock proteins in cell death

Total Award: $4,000



The Mayers Summer Research Internship Award Summer 2007

Doolittle, J. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of the regulation of apoptosis: mathematical and system biology

Total Award: $4,000



Glenn-Stokes Summer Research Internship at OSU Summer 2007

The student is from University of Dayton

Arasu, M. (student) Doseff, A.I. (Mentor)

Title: Pathways of cell fate

Total Award: $4,500



The Mayers Summer Research Internship Award Summer 2004

Reno, E. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of caspase-3 regulation by hsp27.

Total Award: $3,000



Arts & Sciences Undergraduate Research Scholarship Winter 2003

Vargo, M. (student) Doseff, A.I. (Mentor)

Title: The role of caspase-3 regulation in cell death of breast cancer cells

Total Award: $1,000



OSU-CCC Summer Internship Program Summer 2002

Sancaktar, O. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of FAS-dependent apoptosis

Total Award: $2,500 and Travel Award for meeting



Undergraduate Enrichment Fund from College of Biological Sciences Spring 2004

Kolattukudy, S.J. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of caspase-3 and hsp27 in apoptosis.

Total Award: $300



Dean’s College of Biological Sciences Undergraduate Research Award

Kamran, H., Winter 2010

Kamran, H., Winter 2009

Kamran, H., Fall 2008

Murnan, E., Wi 2008

Doolittle, J., Au and Wi 2007

Taylor, C., Wi 2006

Kollatukudy, S.J. Wi 2004

Reno E., Fall 2004

Vargo, M., Sp 2002



Total Award in each case: $300



ii) Awards Received by my Undergraduate and Post-baccalaureate Students for Best Poster Presentations (* indicates name of undergraduate and # indicates name of post-baccalaureate; 6 since my last promotion)



2015 Alers Velazquez,# R.M., Li, W., Valentin Morales, J., Prada Salcedo, L.D., Gray, J., Grotewold, E., and Doseff, A.I. (Poster, March 21-22, Awarded best poster). Characterization of PALs transcriptional regulatory network in maize. ASPB Midwestern Conference. St. Louis. MI.



2012 Tossey, J.*, Voss, O.H., and Doseff, A.I. Molecular Identification of Hsp27 Anti-Apoptotic Activity. (Poster Awarded 2nd place). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Tossey, J.*, Voss, O.H., and Doseff, A.I. Molecular fingerprinting of Hsp27-anti-apoptotic activity. (Poster-October 11, Awarded 2nd place undergraduate student category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Brahimaj, B.*, Arango, D., and Doseff, A.I. Molecular mechanisms of anti-carcinogenic flavonoids. (Poster-May11, Awarded Best Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Tossey, J.*, Voss, O.H., and Doseff, A.I. Molecular identification of Hsp27-anti-apoptotic activity. (Poster-April 29. Awarded Best Poster). Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2008 Doolittle, J.M.*, Aguda, B., Doseff, A.I. Mathematical modeling of PKCδ-mediated activation of caspase-3 during cell death. (Awarded Best Poster). College of Biological Sciences Undergraduate Research Colloquium. The Ohio State University, Columbus, Ohio.



iii) Publications by my Undergraduate and Post-baccalaureate Students (* indicates undergraduate and # indicates post-baccalaureate; 7 since my last promotion)



1. Arango, D., Diosa-Toro, M.#, Rojas-Hernandez, L.S.#, Cooperstone, J.L., Schwartz, S., Mo. X., Jiang, J., Schmittgen, T.D., and Doseff, A.I . (2015). Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. Mol. Nutrit. Food Res. 59: 763-772.



2. Gray, J., Burdo, B., Goetting-Minesky, M. P., Wittler, B., Hunt, M., Li, T., Velliquette, D., Thomas, J., Key, K., Gentzel, I., dos Santos Brito, M., Mejía-Guerra, M.K., Connolly, L. N., Qaisi, D.*, Li, W., Casas, M. I., Doseff, A.I., and Grotewold, E. (2015). Protocol for the Generation of a Transcription Factor Open Reading Frame Collection (TFome). BioProtocols. (In Press).



3. Burdo, B., Gray, J., Goetting-Minesky, M. P., Wittler, B., Hunt, M., Li, T., Velliquette, D., Thomas, J., Gentzel, I., dos Santos Brito, M., Mejía-Guerra, M.K., Connolly, L. N., Qaisi, D.*, Li, W., Casas, M. I., Doseff, A.I., and Grotewold, E. (2014). The Maize TFome: Development of a transcription factor open reading frame collection for functional genomics. Plant J. 2: 353-366. PMID: 25053252.



4. Arango, D., Morahashi, K., Yilmaz, A., Kuramichi, K., Parihar, A., Brahimaj, B.*, Grotewold, E., and Doseff, A.I. (2013). Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. Proc. Natl. Acad. Sci. USA. 110: E2153-2162. PMID: 23697369.



5. Hostetler, G., Schwartz. S., Diosa-Toro, M.#, Riedl, K., Arango, D., and Doseff, A.I. (2012). Flavone deglycosylation increases their anti-inflammatory activity and absorption. Mol. Nutrit. Food Res. 56: 558-569. PMID: 22351119.



6. Gonzalez-Mejia, M.E., Voss, O.H., Murnan, E.J.*, and Doseff, A.I. (2010). Apigenin-induced-apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of Heat Shock Protein 27. Cell Death Disease. 1:e64. PMID: 21364669.



7. Wood, K. L., Nunley, D.R., Moffat-Bruce, S., Pope-Harman, A., Huang, Q., Shamo, E.N.*, Philips, G.S., Barna, C., Batra, S., Marsh, C.B., and Doseff, A.I. (2010). The role of Heat Shock Protein 27 in Bronchiolitis obliterans syndrome after lung transplantation. J. Heart and Lung Transplantation. 29: 786-791. PMID: 20456980.



8. Voss, O.H., Batra, S., Kolattukudy, S.J.*, Gonzalez-Mejia, M.E., Smith, J., and Doseff, A.I. (2007). Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. J. Biol. Chem. 282: 25088-25099.





iv) Additional Undergraduate Students Trained in my Laboratory



2012-2015 Li, Joanna. Honor Student Pre-medicine.

2012-2015 Shao, Quinhui. Honor Student Molecular Genetics.

2012-2013 Rice, Erin. Honor Student Molecular Genetics.

2010-2012 Sarmiento, Cristina. Honor Student Biology



v) Additional Undergraduate Students Trained in my Laboratory, Name of Summer Program (13 since my last promotion)



2015 Sterner, Zacchary. REU (Research experience undergraduate)-Molecular Genetics.

2015 Bliss, Alessandra. REU (Research experience undergraduate)-Molecular Genetics.

2014 Nardone-White, Dasean. REU (Research experience undergraduate)-Molecular Genetics.

2014 Taitano, Daniel. Research experience undergraduate (SUCCESS).

2013 Samantha, Valdez. Research experience undergraduate (SUCCESS).

2013 Matos, Nieve, Adrianna. SROP.

2013 Harder, Matthew. REU (Research experience undergraduate)-Molecular Genetics.

2012 Hong, Harry. Research experience undergraduate (SUCCESS).

2012 Garza, Johan. REU (Research experience undergraduate)-Molecular Genetics.

2011 Tietz, Kiel. REU (Research experience undergraduate)-Molecular Genetics.

2010 Hernandez, Jennifer. REU (Research experience undergraduate)-Molecular Genetics.

2008 Crisafi, Sean. REU (Research experience undergraduate)-Molecular Genetics.

2008 Benson, Jennifer.

Noteworthy Graduate Narrative

i) Fellowships and Awards Received by my Graduate Students (9 since my last promotion)



Colciencias (NSF equivalent from Colombia) pre-doctoral fellowship 1/01/15-12/31/18

Duarte, S. (Predoctoral student) Doseff A.I. (Mentor)

Title: Immune-regulatory mechanisms of dietary flavonoids

Total award: $150,000



Keystone Symposia Future of Science Fund Scholarship. 1/01/14

Keystone Symposia. Silverthorne, CO. Competitive fellowship covered the trip to attend the Keystone Meeting.

Arango, D. (Predoctoral student) Doseff A.I. (Mentor)



Pelotonia Pre-doctoral Research Fellowship 7/01/13-6/30/15

Arango, D. (Predoctoral student) Doseff A.I. (Mentor)

Title: Molecular mechanisms of dietary flavonoids in breast cancer: novel role of nutraceuticals inregulating alternative splicing

Total award: $53,000



Food and Innovation Center Research Student Grant 1/31/13-12/31/13

Arango, D. (Predoctoral student) Doseff A.I. (Mentor)

Title: Chemopreventive mechanisms of newly formulated apigenin-rich diets in breast cancer

Total Award: $5,000



Travel Award Best Poster presentation 12th Trainee Research Day College of Medicine 04/13

Arango, D. (Predoctoral student) Doseff A.I. (Mentor)

Total Award: $1,000



Food and Innovation Center Travel Award to attend the Experimental Biology Meeting 04/13

Arango, D. (Predoctoral student) Doseff A.I. (Mentor)

Total Award: $500



Enlaza Mundos, Master Student Fellowship from Univ. Colombia, Medellin 04/01/11-03/31/12

Pineda, C. (student) Doseff A.I. (Mentor)

Title: Regulation of flavones in adipogenesis

Total award: $15,000



PHPID-Predoctoral Fellowship (Public Health Preparedness for infectious diseases) 1/31/11-12/31/11

Arango, D., (Predoctoral student) Doseff A.I. (Mentor)

Title: Regulation of the TLR-mediated innate immune response by the flavonoid apigenin.

Total Award: $35,000



American Heart Association Predoctoral Fellowship 07/01/06-06/31/09

Voss, O. (Predoctoral student) Doseff A.I. (Mentor)

Title: Regulation of human monocyte apoptosis by caspase-3 and small heat shock proteins.

Total Award: $42,000

Graduate School approved and waived the full cost of tuition



ii) Awards received by my Graduate Students for Best Poster Presentations (* indicates the name of the graduate student awardee; 13 since my last promotion)



2013 Arango, D.*, Morohashi, K., Yilmaz, A., Brahimaj, B., Kuramochi, K., Parihar, A.,Grotewold, E. and Doseff A.I.(Poster-April 11- Awarded 1nd place graduate student category). The 12th Annual Ohio State University Medical Center and Graduate and Postgraduate Trainee Research Day. The Ohio State University, Columbus, Ohio.



2012 Duarte San Miguel, S.*, Pineda, C., Arango, D., and Doseff A.I. Effect of apigenin on metabolic dysfunction in adipose tissue. (Poster-May 31. Awarded best poster) The 9th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2011 Arango, D.*, Morohashi, K.,Yilmaz, A., Guttridge, D.C., Hei, W., Kuramochi, K., Grotewold, E., and Doseff A.I. Innovative approach towards understanding the anti-inflammatory mechanisms of the flavonoid apigenin. (Poster-October 11, Awarded 2nd place graduate student category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Hostetler, G.*, Riedl, K., Cardenas, H., Diosa-Toro, M., Schwartz, S., and Doseff A.I. Deglycosilation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice. (Poster-April 9-14; Selected oral presentation). Experimental Biology, Washington, DC.



2010 Malavez, Y.*, and Doseff A.I.Role of PKCδ dependent phosphorylation of caspase-3 on programmed cell death. (Selected Plenary talk, 1st place award). The Interdisciplinary Graduate Programs Symposium in the Molecular Life Sciences (MCDB, OSBP, and Biophysics). The Ohio State University, Columbus, Ohio.



2010 Arango, D.*, Morohashi, K., Wang, L., Heine, G., Freitas, M. A., Grotewold, E. and Doseff A.I.Anti-carcinogenic mechanisms of the plant flavonoid apigenin. (Poster, 1st place). The 7th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2010 Voss, O.H.*, Parihar, A., Huang, Q., Wood, K., and Doseff A.I. Determination of cellular life span from cells of the innate and adaptive immune system by the heat shock protein 27. (Poster, 1st place Graduate student category). The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, Ohio.



2009 Voss, O.H.* and Doseff A.I. Regulation of caspase-3 by heat shock proteins. (Oral presentation, 3rd place). 35th Edward F. Hayes Graduate Research Forum. The Ohio State University, Columbus, Ohio.



2009 Voss, O.H.*, Parihar, A, Huang, Q., Porcu, P., Wood, K., and Doseff A.I. Regulation of CD8+CD57+ lymphocytes cell fate by heat shock proteins. (Poster, 1st place Graduate student category). 8th Annual OSU-Medical Center Research Day, Columbus, Ohio.



2009 Voss, O.H.* and Doseff A.I. Regulation of caspase-3 by heat shock proteins. (Oral presentation, 3rd place graduate student category). Scott Falkenthal Memorial Graduate Student Colloquium. The Ohio State University, Columbus, Ohio.



2008 Voss, O.*, Parihar, A., Huang, Q., Wood, K.L., and Doseff A.I.Apoptosis is regulated by the interaction of caspase-3 with PKCδ and Hsp27. (Poster, 1st place). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2008 Voss, O.H.*, Malavez, Y.*, Gonzalez-Mejia, M.E., Batra, S., and Doseff A.I. Falkenthal Memorial Graduate Student Colloquium. Regulation of cell fate by PKCδ-dependent phosphorylation of caspase-3 and its association with hsp27. (Best oral presentation). The Ohio State University, Columbus, Ohio.



2008 Voss, O.H.*, Malavez, Y.*, Gonzalez-Mejia, M.E., Batra, S., and Doseff A.I. Regulation of cell fate by caspase-3, PKCδ, and Hsp27. (Best graduate student poster). The 7th Annual OSU-Medical Center Research Day. The Ohio State University, Columbus, Ohio.



2007 Nicholas, C.*, Batra, S., Vargo, M.A.*, Voss, O.H.*, Gavrilin, M.A., Guttridge,D., Grotewold, E., Wewers, M.D. and Doseff A.I.The flavonoid apigenin suppresses acute lung injury. (Poster presentation selected for Oral, 2nd place best oral presentations). 1th Molecular Life Sciences Interdisciplinary Graduate Programs Symposium. The Ohio State University, Columbus,

Ohio.



2007 Sharma, A.*, Vargo, M.A.*, Voss, O.H.*, Batra, S., and Doseff A.I. (Apigenin-induced apoptotic release of histones H2B and H4 to the cytoplasm. (Poster). 2nd place in poster presentations). The 2nd Annual Davis Heart and Lung Research Institute Research Retreat. The Ohio State University, Columbus, Ohio.



2006 Voss, O. H.* and Doseff A.I. Caspase-3 phosphorylation by PKCδ has a proapoptotic effect. (Poster, best graduate student poster). The 5th Annual Medical Center Graduate and Postgraduate Research Day. The Ohio State University, Columbus, Ohio.



2006 Voss, O.H.*, Sharma, A.* and Doseff A.I. Biennial Retreat Molecular Biology and Cancer Genetics Program. Atwood Lake Resort, Ohio. (Best poster selected for podium presentation).



iii) Publications by my Graduate Students (* indicates the graduate student name; 15 since my last promotion)



1. Parihar, A., Duarte, S.* and Doseff A.I. (2015). The saga of food supplements: safety and missing knowledge. Commentary in: J. Med. Active Plants. (In Press).



2. Arango, D.*, Diosa-Toro, M., Rojas-Hernandez, L.S., Cooperstone, J.L., Schwartz, S., Mo. X., Jiang, J., Schmittgen, T.D., and Doseff A.I. (2015). Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. Mol. Nutrit. Food Res. 59: 763-772.



3. Malavez, Y.*, Voss, O.*, Parihar, A., Gonzalez-Mejia, M.E. and Doseff A.I. (2015). Distinct contribution of PKCδ and PKCε in the lifespan and immune response of human blood monocyte subpopulations. Immunology. 144: Issue 4: 611–620.



4. Casas, M.I., Duarte, S.M.*, Doseff A.I.#, and Grotewold, E#. (2014). Flavone-rich maize: An opportunity to improve the nutritional value of an important commodity crop. Frontiers in Plant Sciences (In Press). 5: 1-11. #Shared corresponding author. PMID: 25250036.



5. Duarte, S.*, Arango, D.*, Yasmeen, R. Parihar, A., Hamel, P., and Doseff A.I. (2013). Apigenin protects endothelial cells of LPS-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function. International Journal of Molecular Sciences. 14: 17664-17679. PMID: 23989609.



6. Arango, D.*, Morahashi, K., Yilmaz, A., Kuramichi, K., Parihar, A., Brahimaj, B., Grotewold, E., and Doseff A.I. (2013). Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. Proc. Natl. Acad. Sci. USA. 110: E2153-2162. PMID: 23697369.



7. Naomi, R.B., Wang, B., Voss, O.*, Doseff A.I., Santhoshkumar, P. and Nagaraj, R.H. (2013). Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization and opacification in experimental cataracts. J. Biol. Chem. 288. 13022-13035. PMID: 23508955.



8. Arango, D.*, Parihar, A., Villamena, F.A., Wang, L., Freitas, M.A., Grotewold, E., and Doseff A.I. (2012). Apigenin induces DNA damage through the PKCδdependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochem. Pharmacol. 4: 1571-1580. PMID: 22985621.



9. Das, A., Gopalakrishnan, B., Voss, O.H.*, Doseff A.I.and Villamena, F.A. (2012). Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling. Biochem. Pharmacol. 84: 486-497. PMID: 22580046.



10. Hostetler, G.*, Schwartz. S., Diosa-Toro, M., Riedl, K., Arango, D.,* and Doseff A.I. (2012). Flavone deglycosylation increases their anti-inflammatory activity and absorption. Mol. Nutrit. Food Res. 56: 558-569. PMID: 22351119.



11. Akhter, A., Caution, K., Khweek, A.A., Tazi, M.F., Abdulrahman, B.A., Abdelaziz, D.H., Voss, O.H.*, Doseff A.I., Hassan, H., Azad, A.K., Schlesinger, L.S., Wewers, M.D., Gavrilin, M.A., Amer, A.O. (2012). Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin independently of caspase-1. Immunity 37: 35-47. PMID: 22658523.



12. Gonzalez-Mejia, M.E., Voss, O.H.*, Murnan, E.J., and Doseff A.I. (2010). Apigenin-induced-apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of Heat Shock Protein 27. Cell Death Disease. 1:e64. PMID: 21364669.



13. Wood, K.L., Voss, O.H.*, Huang, Q., Parihar, A., Metha, N., Batra, S., and Doseff A.I. (2010). The small heat shock protein 27 is a key regulator of CD8+CD57+ lymphocyte survival. J. Immunol. 184:5582-5588. Selected for “In this issue” special editor’s commentary. PMID: 20385876.



14. Pasupuleti, N., Matsuyama, S., Voss, O.H.*, and Doseff A.I., Song, K., Danielpour, D., Nagaraj, R. (2010). Anti-apoptotic functions of human A-crystallin: relation to the chaperone function. Cell Death and Disease. 1(3):e31. PMID: 221364639.



15. Malavez, Y.*, Gonzalez-Mejia, M.E., and Doseff A.I. (2008). PKCδ. Atlas Genet Cytogenet Oncol Haematol. URL: http://AtlasGeneticsOncology.org/Genes/



iv) Patents (* Indicates the name of the graduate student)



Processes for improving absorption and anti-inflammatory activity of dietary flavones

Inventors: Doseff A.I., Schwartz, S., Hostetler, G.*, Riedl, K., Cardenas, H. 1/15/11.

Postdoctoral / Researcher Advising

i) Currently in my Laboratory



2012-Present Wei Li Postdoctoral Researcher

2014-Present Marcelo Pereira Postdoctoral Researcher



ii) Post-docs Trained in my Laboratory and Current Positions



2010-2013 Voss, Oliver H., PhD Postdoctoral Researcher, currently postdoc at NIH



2013-2013 Yasmeen, Rumana, PhD Postdoctoral Researcher, currently postdoc at OSU



2011-2012 Parihar, Arti, PhD Visiting Professor, currently Associate Professor, Government Post Graduate College Center of Excellence, Ujjain, MP, India



2006-2012 Gonzalez-Mejia, Martha Elba, MD, PhD Postdoctoral Researcher, currently Assistant Professor at the University of Puebla, Mexico



2009-2010 Cardenas, Horacio, PhD Research Scientist, currently Research Assistant Professor, Indiana University



2006-2007 Batra, Sanjay, PhD Postdoctoral Researcher, currently Research Associate Professor, Southern University and A&M College



2003-2004 Batra, Sanjay, PhD Visiting Scientist



2009-2010 Heine, George, PhD Postdoctoral Fellow, currently lecturer



2007-2008 Porchia, Leonardo PhD Postdoctoral Fellow, currently research associate



2008-2009 Parihar, Arti PhD Postdoctoral Researcher



2008-2009 Omata, Waka, PhD Postdoctoral Researcher, current research associate



2012-2015 Kovinick, Nikolas, PhD (co-advisor: Doseff, A.I.) Postdoctoral Researcher, current Assistant Professor at the University of West Virginia



iii) Post-Doctoral Fellowships Awarded to my Postdocs



Science without borders, Post-doctoral Research Fellowship from Brazil 11/01/14-10/30/16

Pereira, M. (Postdoc) Doseff, A.I. (Mentor).

Title: Regulatory networks responsible for the health beneficial effects of apigenin.

Total award: $50,000



Travel Award Best Poster presentation 12th Trainee Research Day College of Medicine 4/01/13

Voss, O. (Postdoc) Doseff, A.I. (Mentor).

Total Award: $1,000



Pelotonia Post-doctoral Research Fellowship 10/01/12-9/30/14

Kovinich, N. (Postdoc) E. Grotewold (Mentor) Doseff, A.I. (co-Mentor)

Title: New Frontiers in the Chemical Arsenal Against Cancer: Combining Modules of Semi-Synthesis and Synthetic Biology

Total Award: $98,600



NCI-Ruth L. Kirschstein 04/30/09-8/31/10

Heine, G., (Postdoc) Doseff, A.I. (Mentor)

Title: The role of BRCA1 in response to DNA damage

Total Award: $45,000



NIH-T32

Porchia, L., (Postdoc) Doseff, A.I. (Mentor) 01/01/08-01/31/09

Title: Regulation of monocyte fate by caspase 3, Heat Shock Protein 27 and Protein Kinase Cδ

Total Award: $44,000



iv) Awards Received by my Post-Docs for Best Poster Presentations (* indicates name of the postdoctoral awardee; 8 since the last promotion)



2014 Yang, F.*, Li, W., Doseff, A.I.. and Grotewold, E. (Awarded 2nd Best Poster). The 8th Tripartite Workshop, Rutgers University, University of São Paulo, Brazil, and The Ohio State University. For sustainable technology innovations: integrating biology and chemistry for energy, food security and medicine. Rutgers, New Jersey. (Poster-Nov. 14-17).



2013 Voss, O.H.*, Tossey, J., and Doseff, A.I. Anti-apoptotic proteins: essential regulators of monocyte to macrophage life span and differentiation. (Poster-April 11- Awarded 1nd place post-doc category). The 12th Annual Ohio State University Medical Center and Graduate and Postgraduate Trainee Research Day. The Ohio State University, Columbus, Ohio.



2011 Voss, O.H.*, Tossey, J., and Doseff, A.I. Role of Hsp27 in monocyte to macrophage life span and differentiation. (Poster-October 11, Awarded 1st place postdoc category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Voss, O.*, Parihar, A., Huang, Q., Wood, K., and Doseff, A.I. Hsp27 determines cell fate of cell cells from the innate and adaptive immune system by regulating the activation of caspase-3. (Poster- 1st place postdoc category). The 5th Annual Pulmonary, Allergy, Critical Care and Sleep Research Day. The Ohio State University, Columbus, Ohio.



2010 Cardenas, H.*, Nicholas, C., Nishijima, Y., Nuovo, J., and Doseff, A.I. The anti-inflammatory flavonoid apigenin reduces mortality in a mouse model of acute inflammation by inhibiting lung neutrophil infiltration and reducing MIP-2 chemokine expression. (Poster, awarded 1st place staff category). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Voss, O.*, and Doseff, A.I. Monocytes and macrophages life span is regulated by the association of caspase-3 with Hsp27. 2010. (Poster, 1st place postdoc category). The 10th Annual Dorothy M. Davis Heart & Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2009 González-Mejia M.E.*, Murnan E.J., Voss O.H.+, and Doseff, A.I. Apigenin-induced a bimodel phosphorylation of heat shock protein 27 via p38-MAPK and PKCδ regulates mitochondrial depolarization during apoptosis. (Poster). Cell Death Meeting. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. Travel Award.



2009 Gonzalez-Mejia, M.E.*, Murnan, E., Voss, O.H., and Doseff, A.I. Regulation of apoptosis by the association of caspase-3 with hsp27: role of Hsp27 phosphorylation. (Poster, 2nd Place Post-doc category). 11th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2007 Batra, S.*, Nicholas, C., Vargo, M.A., Voss, O.H., Gavrilin, M.A., Guttridge,D., Grotewold, E., Wewers, M.D. and Doseff, A.I. The flavonoid apigenin regulates the production of inflammatory cytokines by promoting the dephosphorylation and inactivation of NF-κB in LPS stimulated monocytes. (Poster selected for Podium presentation, 3rd place best oral presentation). The 2nd Annual Davis Heart and Lung Research Institute Research Retreat. The Ohio State University, Columbus, Ohio.

Master/Graduate Advising

i. Doctoral Students (Dissertations committee member)



National



2013 Wang, T-Y. A.

2013 Hostetler, G. co-advisor



ii. Doctoral Students (Candidacy examination committee chair)



2013 Woods, P. Biomedical Sciences PhD graduate program.

2011 Hostetler, G. Food and Technology graduate program. College Food and Technology.



iii. Doctoral Students (Candidacy examination committee member)



National



2015 Kara Braunreiter. Molecular Genetics graduate program

2014 Meriam Waqas. Molecular Genetics graduate program

2013 Jeremy Baeten. Biomedical Sciences PhD graduate program

2011 Tse-Yao Arthur Wang. Molecular Cellular Developmental Biology program

2009 Claudia Berdugo. College of Engineering



International



2015 Echeverri, L.

Institution: University of Medicine CES-Medellin, Colombia. (February 15). Candidacy exam committee member



2014 Rodrigues da Silva, D.I.

Institution: Dual PhD Program OSU-University São Paulo, Brazil



iv. Visiting Scholars (International Post-baccalaureates) Trained in my Laboratory (9 since the last promotion)



2014-Present Prada-Salcedo, L.

Institution: B.S. Pontificia University Javeriana, Bogota, Colombia and M.Sc. National University of Colombia, Bogota



2014-2014 Rojas, L.

Institution: University of Antioquia, Medellin, Colombia



2014-2014 Merchand-Reyes, G.

Institution: B.S. Biology and Pharmaceutical chemistry, National University of Mexico (UNAM). MSc. In Immunology, National School of Biol. Sci. Mexico



2012-2014 Florez, L.

Institution: University of Antioquia, Medellin, Colombia



2012-2013 Duarte-San Miguel, S.

Institution: University of Bogota, Colombia



2012-2013 Wafula, M.

Institution: University of Nairobi, Kenya



2011-2012 Pineda-Molina, C.

Institution: National University of Colombia, Medellin, Colombia



2010-2011 Diosa-Toro, M.

Institution: University of Antioquia, Medellin, Colombia



2009-2010 Federico, M. B.

Institution: University of Buenos Aires, Argentina





v. Post-baccalaureate Students Trained in my Laboratory (9 since the last promotion)



2015- Present Morales-Montilla, D. SiGuE (Success In Graduate Education) fellow-NSF

2014-2015 Alers Velazquez, R. SiGuE (Success In Graduate Education) fellow-NSF

2014-2015 Lopez, E. SiGuE (Success In Graduate Education) fellow-NSF

2013-2014 Valentin, J. SiGuE (Success In Graduate Education) fellow-NSF

2013-2013 Kayanga, G. SiGuE (Success In Graduate Education) fellow-NSF

2013-2013 Mills, M. SiGuE (Success In Graduate Education) fellow-NSF

2011 Warren, T. R25-Discovery Prep (NIH)

2010 Apiagyei, M. R25-Discovery Prep (NIH)

2010 Cordero, H. R25-Discovery Prep (NIH)



vi. Graduate Students Rotations



15 since 2008

Undergraduate, Graduate, and Professional Courses Taught

Undergraduate Courses



2002-2009 Molecular Genetics 500 (Department of Mol. Genetics. Core class for undergraduate students).

Credit hrs: 5. Students enrolled: 275 to 325. Period: Fall quarter.

Content: Molecular biology and genetics. Course for non-major genetic students.

Contribution: I was responsible for half of all the lectures, designing half of the midterms and half of the final. I managed 6 to 7 teaching assistants and provided office hours.



2013 Atlas Genome Journal Club. Offered: January to May 2013, twice a month.

Students attending: 11

Content: knowledge of latest technologies used for genome-wide analysis including Gateway cloning, yeast one and two hybrid, introduction to software used in GWAS analyses and bioinformatics approaches to identify gene regulatory networks.

Contribution: I developed the curriculum. I presented 50% of all the 30 min. lectures and I was responsible of promoting and mediating the discussions. I selected the articles presented in class. The other 50% of the lectures were done by one of my postdocs as part of her career’s development plan.



2002-Present Molecular Genetics 699/4998-4999. Research for undergraduate students.

Credits hrs: 1 to 5. Students enrolled: 1 to 4 depending the semester. Taught all semesters

Content: This course is for undergraduate students performing research in my laboratory.

Contribution: I meet with students one-to-one once per week to discuss experimental design, analyze data, prepare data for publication.



2002-Present Molecular Genetics H783/4999-4998. Research for honor students.

Credits hrs: 1 to 5. Students enrolled: 1 to 3 depending on the semester. Taught all semesters.

Content: This course is for students performing research in my laboratory that are conducting an honor research thesis.

Contribution: I meet with students once per week one-to-one to teach them how to design experiments. We also meet once a week in lab meetings as a group, where trainees will present current progress of their research. I teach students interpreting data, write fellowship, scientific articles, posters and the honor thesis. I also help students with oral presentations.



Graduate Courses



2013-Present Molecular Genetics 5796. Topics in Signal Transduction.

Credits hrs: 1 to 2. Students enrolled: 8 (in 2013) and 13 (in 2014). Fall semester.

The course is directed to PhD students from several different programs including: Molecular Genetics, Molecular Cellular and Development Biology, OSBP, Nutrition, Optometry, and by senior undergraduate students from different majors.

Content: Network theory applied to signal transduction pathways involved contributing to the pathophysiology of inflammatory diseases and cancer. As part of the course students were also required to present an article in groups followed by discussion and write an abstract that was graded.

Contribution: I developed the curriculum, provided 100% of the lectures, developed and graded final, midterms, exercises and presented a hands-on workshop on large data analyses.



2009-2012 Molecular Genetics 660. Integrated Molecular and Cellular Biology for non-biologist I.

Credit hrs: 5. Students enrolled: 8 to 12 depending on the year. Fall semester.

Content: This course was intended for master and PhD students in Mathematics. The course consisted in lectures, interactive activities and included also one week of laboratory experience and one day of poster presentations by the students and 3 days of manuscript presentations.

Contribution: I developed the curriculum in collaboration with Drs. H. Chamberlain and E. Grotewold. I taught 40% of all the lectures during the fall semester, developed and graded midterms and finals. Lead discussion during paper presentations.



2002-Present Molecular Genetics 8999.

Credits hrs: 1 to 4 depending of the semester. Students enrolled: 1 to 4 depending of the year. Taught all semesters of all years as faculty.

Content: Laboratory research for PhD students.

Contribution: I meet with students once per week, I teach them how to design experiments and help them with data interpretation. I teach students to write fellowship and manuscripts. I also help students with poster and oral presentations. I teach them rational and critical thinking. We also meet once a week 2 hrs for lab meetings.



2002-2012 IBGP703-3-Module II.

Credits hrs: 2. Students enrolled: 20 to 28 depending of the year. Spring quarter.

Content: Mechanisms of sepsis.

Contribution: I was responsible of 1 lecture, developed part of the midterm and the final corresponding to my lecture.



2002-2012 IBGP706.

Credits hrs: 2. Students enrolled: 25 to 30 depending of the year. Fall quarter.

Content:
Seminar for students.

Contribution: I was responsible of a two-hour lecture.



2007-Present Molecular Genetics 801.

Credits hrs: 1. Students enrolled: 3 to 9 depending of the year. Taught all year.

Content: Seminar series, presentation for incoming students.

Contribution: I contribute with one presentation.



2002-2012 Molecular Genetics 795.

Credits hrs: 1. Students enrolled: 1 to 4 depending of the year. Taught all year.

Content: Seminar series, presentation for incoming students.

Contribution: I contribute with one presentation per quarter or semester, lead discussion, teaching students how to present their findings.



2011 Interdepartmental Seminar in Nutrition-ANIMSCI 898; FDSCTE 898; HUMNNTR 898.

Credits hrs: 2. Students enrolled: 60. Human Nutrition, Animal Sciences and Food Science and Technology. Contributed with one lecture, April 8, 2011.

Content: Seminar presentation for master and graduate students about mechanisms of nutraceuticals.

Contribution: I was responsible of a 2 hrs. lecture.



2007-Present MCDB 800. Molecular Cellular and Developmental Biology

Credits hrs: 1. Students enrolled: 25 to 32 depending of the year. Fall quarter/semester

Content: Seminar series, presentation of scientific projects for incoming students.

Contribution: I contribute with one presentation.



Professional Courses



2002-2008 Immunology Review Seminars.

Students attending: 5. Taught all year.

Content: Topics in apoptosis, basic molecular biology, molecular genetics and signal transduction.

Contribution: I contributed with 8, 2 hrs lectures. These weekly seminars for postdoctoral and fellows was part of Training Grant Pulmonary and Critical Care (NIH-T32) educational development program.



Courses and Presentation for Professional Development (only listed since the last promotion)



2015 Career development panel discussion for undergraduate students SUCCESS program. (June 15). The Ohio State University.



2014 Professional development series for women faculty: Finding your faculty career niche (January 15). The Ohio State University.



2014 American Heart Association grant development panel discussion for graduate students and postdocs (May). The Ohio State University.



2014 Building research leaders. Gender initiatives in STEM, Project CEOS and the Women’s place. Finding your faculty career niche. (February 28). The Ohio State University.



2013 Development of international training programs. (April 12). University of São Paulo, Brazil.



2012 Opportunities for graduate education in STEM disciplines. (November 22). University of Mayaguez, Puerto Rico, USA.

Creative Works

Poster Presentations (129 since the last promotion from a total of 200)



2015 Yang, F. Li, W., Mukundi, E., Gray, J., Doseff, A.I. and Grotewold, E. Metabolic engineering of maize phenolics. (July 19-24). Gordon Conference-Plant Metabolic Engineering. Waterville Valley, N.H.



2015 Pereira, M.S.F., Arango, D., Duarte, S., Nagarajan, P., Eubank, T. and Doseff, A.I. Dietary anti-cancer apigenin delays tumor development and blocks metastasis by reducing TAMs and myeloid suppressor cells through NF-κB-inactivation. (June 4-6). Great Lakes Breast Cancer Symposium. Cleveland, OH.



2015 Arango, D. Mejia-Guerra, K., Mukundi, E., Eubank, T.D., Padilla-Obregon, F., Grotewold, E and Doseff, A.I. (Poster, May 27). Genome-wide effects on alternative splicing networks by dietary flavonoids restore normal RNA-signatures contributing to halt breast cancer progression. Interdisciplinary Graduate Program Symposium (May 27th). The Ohio State University, Columbus, OH.



2015 Alers Velazquez, R.M., Li, W., Valentin Morales, J., Prada Salcedo, L.D., Gray, J., Grotewold, E., and Doseff, A.I. (Poster, March 21-22, Awarded best poster). Characterization of PALs transcriptional regulatory network in maize. ASPB Midwestern Conference. St. Louis. MI.



2015 Doseff, A.I., Arango, D., Mejia-Guerra, K., Mukundi, E., Eubank, T.D., Padilla-Obregon, F., and Grotewold, E. (Poster, Jan 28-Feb 1). Genome-wide effects on alternative splicing networks by dietary flavonoids restore normal RNA-signatures contributing to halt breast cancer tumor progression and metastasis. Systems Biology, Global Regulation of Gene Expression. Cold Spring Harbor Laboratory meeting, Puerto Rico.



2015 Li, W., Yang, F.,Mejia-Guerra, K., Mukundi, E., Morales, J.V., Prada, L.D., Gray, J., Doseff, A.I. and Grotewold, E. (Poster, March 12-15). Transcription regulatory network controlling phenolic biosynthesis in maize factor-centered approaches reveal emerging properties of plant gene regulatory networks. 57th Annual Maize Genetics Conference

St. Charles, Illinois.



2015 Gray, J., Goetting-Minesky, M.P., Li, T., Velliquette, D., Thomas, J., Burdo, B., Wittler, B., Hunt, M., Gentzel, I., Michael dos Santos Brito, Maria Katherine Mejía-Guerra, Layne N. Connolly, Dalya Qaisi, Casas, M.I., Doseff, A.I. and Grotewold, E. (Poster, March 12-15). The maize TFome development of a transcription factor open reading frame collection for functional genomics. 57th Annual Maize Genetics Conference

St. Charles, Illinois.



2015 Shao, Q., Arango, D., Duarte, S., and Doseff, A.I. Molecular mechanisms of dietary compounds in leukemia and their roles in alternative splicing. (Poster, March 6). Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2015 Grotewold, E, Morohashi, K., Li, W., Yang, F., Mejia-Guerra, K., Gray, J., and Doseff, A.I. (Poster, Jan 28-Feb 1). Gene- and transcription factor-centered approaches reveal emerging properties of plant gene regulatory networks. Systems Biology, Global Regulation of Gene Expression. Cold Spring Harbor Laboratory meeting, Puerto Rico.



2014 Yang, F., Li, W., Doseff, A.I., and Grotewold, E. (Awarded 2nd Best Poster). The 8th Tripartite Workshop, Rutgers University, University of São Paulo, Brazil, and The Ohio State University. For sustainable technology innovations: integrating biology and chemistry for energy, food security and medicine. Rutgers, New Jersey. (Poster-Nov. 14-17).



2014 LI, W., Mejia-Guerra, M.K., Galeanao, N.F., Vidal, M., Grotewold, E., and Doseff, A.I. Genome-wide architecture of transcriptional start sites defined by CAP Analysis of Gene Expression (CAGE) reveals distinct features and evolutionary conservations of genomes. (Poster-October 5). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2014 Arango, D., Nagarajan, P., Duarte, S., Merchand, G., Rojas, L., Eubank, T. and Doseff, A.I. Immune-modulatory and anti-proliferative activities of dietary apigenin act in concert to delay breast cancer progression. (Poster-October 5). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2014 Duarte, S., Arango, D., Taitano, D., Bao, S., Julian, M.W., Crouser, E., Hollyfield, J., Exline, M., Sarkar A., Wewers, M.D., Knoell, D.L., and Doseff, A.I. Anti-inflammatory mechanisms of dietary apigenin: alternative approaches for clinical interventions. (Poster-October 5). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2014 Nardone-White, D., Arango, Dand Doseff, A.I. (Poster November 12-15). Identification of binding sites between the dietary anticancer compound apigenin and the RNA-binding protein hnRNPA2. Annual Biomedical Research Conference for Minority Students. San Antonio, Texas.



2014 Taitano, D., Arango, D. and Doseff, A.I. (Poster July 31). Immunomodulatory mechanisms of the dietary flavonoid apigenin. SUCCESS. College of Medicine. The Ohio State University, Columbus, Ohio.



2014 Nardone-White, D., Arango, D, and Doseff, A.I. (Poster July 31). Identification of binding sites between the dietary anticancer compound apigenin and the RNA-binding protein hnRNPA2. Molecular Genetics, REU. The Ohio State University, Columbus, Ohio.



2014 Arango, D., Duarte, S., Mejia-Guerra, K., Padilla-Obregon, F., Morohashi, K., Eubank, T., Grotewold, E. and Doseff, A.I. (Poster April 10). Transcriptome analyses in concert with animal models reveal the anti-carcinogenic of the dietary flavonoid apigenin in breast cancer. The 13th Trainee Research Day. The Ohio State University, Columbus, Ohio.



2014 Arango, D., Morohashi, K., Yilmaz, A., Mejia-Guerra, K., Kuramochi, K., Parihar, P., Brahimaj, B., Grotewold, E. and Doseff, A.I. (Poster February 23-28). PD-Seq, a novel small-molecule target identification approach, reveals new mechanisms responsible for the anti-inflammatory and anti-carcinogenic activities of dietary flavonoids. Keystone Meeting: The NF-kB system in health and disease. Keystone Colorado.



2014 Lin, J., Arango, D., and Doseff, A.I. (Poster March 26). Identification of apigenin binding sites on hnRNPA2, a RNA-binding protein overexpressed in cancer and inflammatory diseases. Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2014 Li, W., Burdo, B., Valentin Morales, J., Prada Salcedo, L. D., Gray, J., Grotewold, E. and Doseff, A.I. (Poster March 22-23). Identification of Transcriptional Regulatory Networks Controlling Flavonoid Biosynthesis Pathway in Maize. ASPB (American Society of Plant Biology) Columbus, Ohio.



2014 Valentin Morales, J., Li, W., Prada Salcedo, L. D., Burdo, B., Gray, J., Grotewold, E. and Doseff, A.I. (Poster March 22-23). Identification of the transcriptional regulation that controls phenylalanine ammonia lyase (PAL) family in Maize. ASPB (American Society of Plant Biology) Columbus, Ohio.



2014 Burdo, B., Goetting-Minesky, M.P., Li, T., Velliquette, D., Hunt, M., Wittler, B., Gentzel, I., Gilreath, E.R., Dajnowicz, S., Abdollahzadeh, A., Thomas, J., Qaisi, D., Connolly, L., Indurti, A., Key, K., Podolski, R., Mills, M., Carstens, J., Belesky, K., Kusayanagi, T., Casas, M.I., Kataka, E., Morohashi, K., Andrade, T., Mejía-Guerra, K., Reed, A., Machemer-Noonan, K., Mukundi, E., Yu, H-D., Santos, F., Santos Brito, M., Kayanja, G., Engelmeier, J., McFarland, F., Scott, M., Campbell, J., Galeano, F., Li, W., Doseff, A.I., Gray, J., and Grotewold, E. (Poster March 22-23). The First Release of the Maize Transcription Factor ORFeome Collection. ASPB (American Society of Plant Biology). Columbus, Ohio.



2014 San Miguel, S., Arango, D., Parihar, A., Hamel, P., Yasmeen, R., and Doseff, A.I. (Poster March 21). Apigenin prevents LPS-induced ROS production, apoptosis and cardiac dysfunction by protecting mitochondrial functions. The 11th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2014 Doseff, A.I. (Poster February 28). Cell Death Networks: Targeting Complex Molecular Interactions to End Cancer. Comprehensive Cancer Center Annual Meeting. The Ohio State University, Columbus, Ohio.



2013 Doseff, A.I., Arango, D., Mejia-Guerra, K., Restrepo, D., Morohashi, K., Yilmaz, A., Kuramochi, K., Parihar, P., Brahimaj, B., and Grotewold, E. (Poster July 7-12). Identification of human targets of the dietary flavone apigenin reveals novel aspects of the anti-carcinogenic and anti-inflammatory mechanisms of phytochemicals. Gordon Conference-Plant Metabolic Engineering. Waterville Valley, N.H.



2013 Brito, M.S, Vicentini, R., Kiyota, E., Creste, S., Landell, M.G.A., Santos, F.C., Doseff, A.I., Gray, J., Mazzafera, P., and Grotewold, E. (Poster July 7-12) Identification of target genes regulated by the shine transcription factor in monocot plants using CHIP-Seq. Gordon Conference-Plant Metabolic Engineering. Waterville Valley, N.H.



2013 Matos-Nieves, A., Voss, O.H., and Doseff, A.I. (Poster, July 30). Regulation of caspase-3 by the anti-apoptotic proteins XIAP and Hsp27. SROP. The Ohio State University, Columbus, Ohio.



2013 Valdez, S., Arango, D., and Doseff, A.I. (Poster, August 1). Mechanisms of breast cancer chemosensitization by dietary compounds. SUCCESS program. The Ohio State University, Columbus, Ohio.



2013 Harder, M., Voss, O.H., and Doseff, A.I. (Poster, August 1). Using the yeast two-hybrid system to determine caspase-3 prodomain interaction with hsp27. REU-Molecular Genetics/Biochemistry. The Ohio State University, Columbus, Ohio.



2013 Li, W., Carstens,J., Mejía-Guerra, M.J., Morohashi, K., Gray, J., Grotewold, E., and Doseff, A.I. (Poster- March 14-17). The identification of regulatory networks that control phenolic biosynthesis in maize. 55th Annual Maize Genetics Conference. St. Charles, Illinois.



2013 Gray, J., Doseff, A.I. and Grotewold, E. (Poster- March 14-17). Approaches to identify gene regulatory networks in grasses. 55th Annual Maize Genetics Conference. St. Charles, Illinois.



2013 Arango, D., Morohashi, K., Yilmaz, A., Brahimaj, B., Kuramochi, K., Parihar, A., Brahimaj, B., Mejia-Guerra, K., Restrepo, D., Grotewold, E. and Doseff, A.I. (Poster-March 26). Target Identification of Dietary Flavonoids Revels Novel Mechanisms Involved in Their Anti-Carcinogenic Activity. The 10th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2013 Arango, D., Morohashi, K., Yilmaz, A., Brahimaj, B., Kuramochi, K., Parihar, A., Grotewold, E. and Doseff, A.I. (Poster-April 11- Awarded 1nd place graduate student category). The 12th Annual Ohio State University Medical Center and Graduate and Postgraduate Trainee Research Day. The Ohio State University, Columbus, Ohio.



2013 Voss, O.H., Tossey, J., and Doseff, A.I. Anti-apoptotic proteins: essential regulators of monocyte to macrophage life span and differentiation. (Poster-April 11- Awarded 1nd place post-doc category). The 12th Annual Ohio State University Medical Center and Graduate and Postgraduate Trainee Research Day. The Ohio State University, Columbus, Ohio.



2013 Tossey, J.C., Voss, O., and Doseff, A.I. The role of apigenin and Hsp27 in NSCLC apoptosis. (Poster-April). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2013 Tossey, J.C., Voss, O., and Doseff, A.I. The role of apigenin and Hsp27 in NSCLC apoptosis. (Poster-April, Awarded honor category). Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2013 San Miguel, S., Parihar, A., Yasmeen, R., Arango, D., and Doseff, A.I. (Poster-April 11). Mechanisms and functional significance of bioactive food components in mitochondrial dysfunction: potential new translational approaches in inflammation-induced metabolic disorders. The 12th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, Ohio.



2012 Tossey, J.C., Voss, O., and Doseff, A.I. The role of apigenin and Hsp27 in NSCLC apoptosis. (Poster-October 11). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2012 Voss, O.H., Tossey, J., and Doseff, A.I. (Poster-October 11). Anti-apoptotic proteins: essential regulators of monocyte to macrophage life span and differentiation. Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2012 Arango, D., Morohashi, K., Yilmaz, A., Brahimaj, B., Kuramochi, K. Grotewold, E. and Doseff, A.I. Identification of human-flavonoid targets using an innovative approach reveals new mechanisms involved in their anti-inflammatory activities (Selected Oral Presentation April 21-25). Experimental Biology, San Diego, CA.



2012 Tossey, J.C., Voss, O., and Doseff, A.I. Molecular Fingerprinting of Hsp27 Anti-Apoptotic Activity. (Poster-April 21-25). Experimental Biology, San Diego, CA.



2012 San Miguel, S., Pineda, C., Arango, D., and Doseff, A.I. Effect of apigenin on metabolic dysfunction in adipose tissue. (Poster-May 31. Awarded best poster) The 9th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2012 Arango, D., Morohashi, K., Yilmaz, A., Diosa-Toro, M., Hostetler, G., Schwartz, S.J., Hei, W., Guttridge, D., Kuramochi, K. Grotewold, E. and Doseff, A.I. Target identification and regulation of innate immunity by the dietary flavonoid apigenin. (Poster April 27) PHPID. Annual Scientific Meeting. The Ohio State University, Columbus, Ohio.



2012 Tossey, J., Voss, O.H., and Doseff, A.I. Molecular Identification of Hsp27 Anti-Apoptotic Activity. (Poster Awarded 2nd place). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2012 Voss, O.H., Tossey, J., and Doseff, A.I. (Poster-April 18). Role of anti-apoptotic proteins in monocyte to macrophage life span and differentiation. The 11th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, OH.



2012 Pineda, C., Parihar, A., Arango, D., and Doseff, A.I. Effect of apigenin on metabolic dysfunction in adipose tissue. (Poster March 8) 14th OSU-Comprehensive Cancer Center Annual Scientific Meeting. The Ohio State University, Columbus, Ohio.



2012 Arango, D., Morohashi, K., Yilmaz, A., Brahimaj, B., Kuramochi, K. Grotewold, E. and Doseff, A.I. Target identification and anti-carcinogenic mechanisms of dietary flavonoids. (Poster March 8) 14th OSU-Comprehensive Cancer Center Annual Scientific Meeting, The Ohio State University, Columbus, Ohio.



2011 Arango, D., Parihar, A., and Doseff, A.I. The role of plant small metabolite in the regulation of adipocytokine secretion and hypertrophy. (Poster-October 11). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Malavez, Y., Voss, O.H., Kamran, H., and Doseff, A.I. PKCδ regulates cell death and survival through phosphorylation of caspase-3. (Poster-October 11). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Arango, D., Morohashi, K.,Yilmaz, A., Guttridge, D.C., Hei, W., Kuramochi, K., Grotewold, E., and Doseff, A.I. Innovative approach towards understanding the anti-inflammatory mechanisms of the flavonoid apigenin. (Poster-October 11, Awarded 2nd place graduate student category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Voss, O.H., Tossey, J., and Doseff, A.I. Role of Hsp27 in monocyte to macrophage life span and differentiation. (Poster-October 11, Awarded 1st place postdoc category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Tossey, J., Voss, O.H., and Doseff, A.I. Molecular fingerprinting of Hsp27-anti-apoptotic activity. (Poster-October 11, Awarded 2nd place undergraduate student category Best Poster). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Doseff, A.I. Morohashi, K., Arango, D., Yilmaz, A., Kuramochi, K., Brahimaj, B., and Grotewold, E. PD-Seq: Coupling phage-display with next-generation sequencing towards the identification of human cellular targets of the flavonoid apigenin and development of flavonoids nanosensors. (Oral Presentation July 24-29). Gordon Conference-Plant Metabolic Engineering. Waterville Valley, N.H.



2011 Hostetler, G., Riedl, K., Cardenas, H., Diosa-Toro, M. Schwartz, S. and Doseff, A.I. Deglycosylation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice. The 8th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, OH. (Selected oral Presentation).



2011 Brahimaj, B., Arango, D., and Doseff, A.I. Molecular mechanisms of anti-carcinogenic flavonoids. (Poster-May11, Awarded Best Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Tossey, J., Voss, O.H., and Doseff, A.I. Molecular identification of Hsp2-anti-apoptotic activity. (Poster-May 11). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Brahimaj, B., Arango, D., and Doseff, A.I. Molecular mechanisms of anti-carcinogenic flavonoids. (Poster-April 8-9). Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Tossey, J., Voss, O.H., and Doseff, A.I. Molecular identification of Hsp2-anti-apoptotic activity. (Poster-April 29. Awarded Best Poster). Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Hostetler, G., Riedl, K., Cardenas, H., Diosa-Toro, M., Schwartz, S., and Doseff, A.I. Deglycosilation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice. (Poster-April 9-14; Selected oral presentation). Experimental Biology, Washington, DC.



2011 Arango, D., Morohashi, K.,Yilmaz, A., Brahimaj, B., Kuramochi, K., Grotewold, E., and Doseff, A.I. (Poster). Innovative approach towards anti-inflammatory apigenin target identification. (Poster-April 8-9). 4th Annual Translational to Clinical (T2C) Wound Care Conference. The Ohio State University, Columbus, Ohio.



2011 Voss, O.H. and Doseff, A.I. The cellular fate of monocytes and macrophages is regulated by Hsp27. (Poster-April 8-9). 4th Annual Translational to Clinical (T2C) Wound Care Conference. The Ohio State University, Columbus, Ohio.



2011 Brahimaj, B., Arango, D., Morohashi, K., Grotewold, E., and Doseff, A.I. (Poster-April 8-9). Molecular biosensor of flavonoids involved in regulation of inflammation. (Poster-April 8-9). 4th Annual Translational to Clinical (T2C) Wound Care Conference. The Ohio State University, Columbus, Ohio.



2011 Voss, O.H. and Doseff, A.I. Hsp27 determines the cellular life span of monocytes and macrophages. (Poster-April 7). The 10th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, OH.



2011 Arango, D., Morohashi, K.,Yilmaz, A., Brahimaj, B., Kuramochi, K., Grotewold, E., and Doseff, A.I. Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors. (Poster-April 7). The 10th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, OH.



2011 Arango, D., Morohashi, K.,Yilmaz, A., Brahimaj, B., Kuramochi, K., Grotewold, E., and Doseff, A.I. (Poster). Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors. (Poster). 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting. The Ohio State University, Columbus, Ohio.



2011 Malavez, Y., Voss, O.H., Federico, M.B., Kamran, H., and Doseff, A.I. PKCδ-dependent phosphorylation of caspase-3 modulates its enzymatic activity and cell death. (Poster). 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting. The Ohio State University, Columbus, Ohio.



2011 Hostetler, G., Riedl, K., Cardenas, H., Diosa-Toro, M., Schwartz, S., and Doseff, A.I. Deglycosilation of flavones enhances anti-inflammatory activity of food extracst in vitro and absorption of dietary flavones from celery in mice. (Poster). 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting. The Ohio State University, Columbus, Ohio.



2010 Cardenas, H., Nicholas, C., Nishijima, Y., Nuovo, J., and Doseff A.I. The anti-inflammatory flavonoid apigenin reduces mortality in a mouse model of acute inflammation by inhibiting lung neutrophil infiltration and reducing MIP-2 chemokine expression. (Poster, awarded 1st place). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Voss, O.H. and Doseff, A.I. Monocytes and macrophages life span is regulated by the association of caspase-3 with Hsp27. (Poster, awarded 1st place). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Gonzalez-Mejia, M.E., Voss, O.H., and Doseff, A.I. Phosphorylation of Hsp27 reduces its association with caspase-3 inducing monocyte apoptosis. (Poster). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Arango, D., Morohashi, K., Yilmaz, A., Grotewold, E. and Doseff, A.I. Target identification of the flavonoid apigenin: implications for its anti-inflammatory activity. (Poster). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Hostetler, G., Riedl, K., Cardenas, H., Schwartz, S., and Doseff, A.I. Anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice. (Poster). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Malavez, Y., Voss, O.H., Federico, M.B., Kamran, H., Brahimaj, B., and Doseff, A.I. PKCδ phosphorylation of caspase-3 promotes apoptosis through a complex regulatory network. (Poster). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Cardenas, H., Nicholas, C., Nishijima, Y., Nuovo, J., and Doseff A.I. Protective effect of apigenin against mortality induced by acute inflammation in mice is associated with reducition of MIP-2 chemokine expression and lung neutrophil infiltration. (Poster). 5th Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, OH.



2010 Voss, O.H., Parihar, A., Huang, Q., Wood, K., and Doseff, A.I. Hsp27 determines cell fate of cell cells from the innate and adaptive immune system by regulating the activation of caspase-3. (Poster, 1st place). 5th Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine.The Ohio State University, Columbus, Ohio.



2010 Gonzalez-Mejia, M.E., Voss, O.H., and Doseff, A.I. Phosphorylation of Hsp27 reduces its association with caspase-3 inducing monocyte apoptosis. (Poster-1st place). 5th Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2010 Diosa-Toro, M., Arango, D., Hostetler, G., Schwartz, S., and Doseff, A.I. Celery extracts induce in vitro inhibition of NF-kB activity and TNF production in LPS-stimulated macrophages. (Poster). 5th Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2010 Arango, D., Morohashi, K., Yilmaz, A., Grotewold, E. and Doseff, A.I. Anti-inflammatory mechanism of the flavonoid apigenin. (Poster). 5th Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2010 Hostetler, G., Riedl, K., Cardenas, H., Schwartz, S., and Doseff, A.I. Anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice. (Poster). 5th Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2010 Malavez, Y., Voss, O.H., Federico, M.B., Kamran, H., Brahimaj, B., and Doseff, A.I. Phosphorylation of caspase-3 regulates apoptosis through a complex regulatory network. (Poster). 5th Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2010 Hernandez, J. and Doseff, A.I. Mapping the heat shock protein 27 peptide motif responsible for the inhibition of caspase-3 apoptotic activity. (Poster). 24th Annual Summer Research Opportunities Program (SROP) Conference. The Ohio State University, Columbus, Ohio.



2010 Arango, D., Morohashi, K., Wang, L., Heine, G., Freitas, M. A., Grotewold, E. and Doseff, A.I. Anti-carcinogenic mechanisms of the plant flavonoid apigenin. (Poster, 1st place). The 7th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2010 Hostetler, G., Riedl, K., Cardenas, H., Doseff, A.I. and Schwartz, S. Anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in a mouse model. The 7th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2010 Malavez, Y., and Doseff, A.I. Role of PKCδ dependent phosphorylation of caspase-3 on programmed cell death. (Selected Plenary talk, 1st place). The Interdisciplinary Graduate Programs Symposium in the Molecular Life Sciences (MCDB, OSBP, and Biophysics). The Ohio State University, Columbus, Ohio.



2010 Kamran, H., Malavez, Y., Voss, O.H., and Doseff, A.I. Molecular mechanisms of caspase-dependent apoptosis. (Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2010 Brahimaj, B., Malavez, Y., and Doseff, A.I. Molecular mechanisms of caspase-3-PKCδ-dependent phosphorylation in apoptosis. (Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2010 Kamran, H., Malavez, Y., Voss, O.H., and Doseff, A.I. Molecular mechanisms of caspase-dependent apoptosis. (Poster). Biological, Mathematical, and Physical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2010 Brahimaj, B., Malavez, Y., and Doseff, A.I. Molecular mechanisms of caspase-3-PKCδ-dependent phosphorylation in apoptosis. (Poster). Biological, Mathematical, and Physical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2010 Malavez, Y., Voss, O.H., Kamran, H., and Doseff, A.I. Modulation of caspase-3 enzymatic activity by PKCδ phosphorylation during apoptosis. (Poster). The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, Ohio.



2010 Voss, O.H., Parihar, A., Huang, Q., Wood, K., and Doseff, A.I. Determination of cellular life spam from cells of the innate and adaptive immune system by the heat shock protein 27. (Poster). The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, Ohio.



2010 Cardenas, H., Nicholas, C., Grotewold, E., and Doseff A.I. Apigenin reduces mortality in a mouse model of acute lung injury by inhibiting neutrophil infiltration, MIP-2, and apoptosis in the lungs. (Poster). 12th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2010 Arango, D., Morohashi, K., Heine, George., Wang, L., Freitas, MA., Grotewold, E., and Doseff, A.I. Anti-proliferative mechanisms of the flavonoid apigenin. (Poster). 12th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2009 Doseff, A.I., Voss, O.H., Gonzalez-Mejia, M.E. The small heat shock protein 27 regulates monocyte/macrophage survival and differentiation. (Poster). American Thoracic Society International Conference, San Diego, CA.



2009 Voss, O.H, Malavez, Y., Gonzalez-Mejia, M.E., Batra, S., and Doseff, A.I. Regulation of cell fate by PKCδ-depednent phosphorylation of caspase-3 and its association with Hsp27. (Best Oral Presentation). Falkenthal Memorial Graduate Student Colloquium. The Ohio State University, Columbus, Ohio.



2009 Arango, D., Morohashi, K., Nihcolas, C., Grotewold, E., Freitas, M., and Doseff, A.I. Apigenin induces DNA damage in a PKCδ-dependent manner. (Poster). The 3rd Annual Davis Heart and Lung Research Institute Research Retreat. The Ohio State University, Columbus, Ohio.



2009 Voss, O.H, Parihar, A, Huang, Q., Wood, K., and Doseff, A.I. Determination of cellular life span through the intearction of caspase-3 with PKCδ and Hsp27. (Poster). The 3rd Annual Davis Heart and Lung Research Institute Research Retreat. The Ohio State University, Columbus, Ohio.



2009 Gonzalez-Mejia, M.E., Murnan, and Doseff, A.I. Caspase-3 phosphorylation is mediated by the association of PKCδ and Hsp27 during apoptosis. (Poster). The 3rd Annual Davis Heart and Lung Research Institute Research Retreat. The Ohio State University, Columbus, Ohio.



2009 Voss, O.H, Parihar, A, Huang, Q., Porcu, P., Wood, K., and Doseff, A.I. Regulation of CD8+CD57+ lymphocytes cell fate by heat shock proteins. (Poster, Awarded 1st Place Graduate student category). 11th Annual OSU-Medical Center Research Day, Columbus, Ohio.



2009 Arango, D., Morohashi, K., Grotewold, E., and Doseff, A.I. (Poster). Molecular mechanisms of apigenin-induced DNA damage. (Poster). 11th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2009 Voss, O.H, Parihar, A, Huang, Q., Pierluigi, P., Wood, K., and Doseff, A.I. The small heat shock protein 27 regulates CD8+CD57+ lymphocytes cell fate. (Poster). 11th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2009 Gonzalez-Mejia, M.E., Murnan, E., Voss, O.H., and Doseff, A.I. Regulation of apoptosis by the association of caspase-3 with hsp27: role of Hsp27 phosphorylation. (Poster, Awarded 2nd Place Post-doc category). 11th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2009 Murnan, E., Gonzalez-Mejia, M.E., Voss, O.V., and Doseff, A.I. Post-translational modifictaion and regulation of the chaperone Hsp27 during apoptosis. (Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2009 Kamran, H., Malavez, Y., Voss, O.H., and Doseff, A.I. Molecular mechanisms of caspase-dependent apoptosis. (Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2009 Murnan, E., Gonzalez-Mejia, M.E., and Doseff, A.I. Role of Hsp27 in apoptosis. (Poster). 11th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2009 Pasupuleti, N., Matsuyama, S., Doseff, A.I. and Nagaraj, R. The chaperone and anti-apoptosis are intimately related functions in human A-crystallin. (Poster). Association for Research in Vision and Ophthalmology (ARVO). Ft. Lauderdale, FL.



2009 Kamran, H., Malavez, Y., Voss, O.H., and Doseff, A.I. Molecular mechanisms of caspase-dependent apoptosis. (Poster). College of Biological Sciences Undergraduate Research Colloquium. The Ohio State University, Columbus, OH. The Ohio State University, Columbus, Ohio.



2009 Murnan, E., Gonzalez-Mejia, M.E., Voss, O.V., and Doseff, A.I. Post-translational modifictaion and regulation of the chaperone Hsp27 during apoptosis. (Poster). College of Biological Sciences Undergraduate Research Colloquium. The Ohio State University, Columbus, OH. The Ohio State University,

Columbus, Ohio.



2008 Arango, D., Morohashi, K., Nicholas, C., Wang, L., Grotewold, E., Freitas, M., and Doseff, A.I. (Poster). Molecular mechanisms of apigenin-induced apoptosis. (Poster). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2008 Malavez, Y.*, Voss, O.H., Doolittle, J., and Doseff, A.I. PKCδ dependent phosphorylation of caspase-3 modulates cell death during innate immune response (Poster). 3rd Annual Pulmonary Research Day. The Ohio State University. Columbus, Ohio.



2008 Gonzalez-Mejia, M.E., Murnan, E., and Doseff, A.I. PKCδ-dependent phosphorylation of caspase-3 and its association with Hsp27 regulate life span during apoptosis. (Poster, 1st place postdoc category). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2008 Malavez, Y.*, Voss, O.H., and Doseff, A.I. The role of caspase-3 in cell death (Oral presentation). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University. Columbus, Ohio.



2008 Voss, O., Parihar, A., Huang, Q., Wood, K.L., and Doseff, A.I. Apoptosis is regulated by the interaction of caspase-3 with PKCδ and Hsp27. (Poster, 1st place graduate student category). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2008 Parihar, A., Voss, O., Huang, Q., Wood, K.L., and Doseff, A.I. Hsp27 and the Bcl-2 family proteisn as regulators of apoptosis in CD57+/- lymphocytes. (Poster). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2008 Murnan, E., Gonzalez-Mejia, M.E., and Doseff, A.I. Apigenin-indiced Hsp27 phosphorylation (Poster). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, Ohio.



2008 Crisafi, S.*, Malavez, Y., and Doseff, A.I. Regulation of caspase-3 by PKCδ (Poster). The Ohio Student Research Forum. The Ohio State University, Columbus, Ohio.



2008 Wood, K.L., Huang, Q., Phillips, G.S., Shamo, E.N., Marsh, C.B., Baran, C., Moffat-Bruce, S., Pope-Harman, A., Nunley, D.R., and Doseff, A.I. The role of Heat shock protein 27 in Bronchiolitis obliterans after lung transplantation. (Poster discussion). American Thoracic Society International Conference, Ontario, Canada.



2008 Voss, O.H., Malavez, Y., Gonzalez-Mejia, M.E., Batra, S., and Doseff, A.I. Regulation of cell fate by caspase-3, PKCδ, and Hsp27. (Poster-Awarded best graduate student poster). 7th Annual OSU-Medical Center Research Day, Columbus, Ohio.



2008 Doolittle, J.M., Aguda, B., Doseff, A.I. Mathematical model of the intrinsic pathway of apoptosis. (Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2008 Murnan, E., Gonzalez-Mejia, M.E., and Doseff, A.I. Regulation of apoptosis by caspase-3 by hsp27. (Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2008 Shamo, E.N., Huang, Q., Batra, S., Doseff, A.I., and Wood, K. The association of heat shock proteins and alloimmunity after bone marrow transplant. (Poster). 7th Annual OSU-Medical Center Research Day, Columbus, Ohio.



2008 Malavez, Y., Voss, O.H., Doolittle, J., and Doseff, A.I. Regulation of apoptosis by PKCδ-dependent phoshorylation of caspase-3 (Poster). 7th Annual OSU-Medical Center Research Day, Columbus, Ohio.



2008 Gonzalez-Mejia, M.E., Voss, O.H., and Doseff, A.I. PKCδ and Hsp27 regulate monocyte/macrophage cell fate by its direct interaction with caspase-3. (Poster). 7th Annual OSU-Medical Center Research Day, Columbus, Ohio.



2008 Doolittle, J.M., Aguda, B., Doseff, A.I. Mathematical modeling of PKCδ-mediated activation of caspase-3 during cell death. (Awarded Best Poster). College of Biological Sciences Undergraduate Research Colloquium. The Ohio State University, Columbus, Ohio.



2008 Murnan, E., Gonzalez-Mejia, M.E., and Doseff, A.I. Regulation of apoptosis by caspase-3 by hsp27. (Poster). College of Biological Sciences Undergraduate Research Colloquium. The Ohio State University, Columbus, Ohio.



2008 Doolittle, J.M., Aguda, B., Doseff, A.I. Mathematical modeling of PKCδ-mediated activation of caspase-3 during cell death. (Poster). 10th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2008 Voss, O.H., Malavez, Y., Gonzalez-Mejia, M.E., Batra, S., and Doseff, A.I. Regulation of cell fate by caspase-3, PKCδ, and Hsp27. (Poster). 10th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2008 Gonzalez-Mejia, M.E., Voss, O.H., and Doseff, A.I. Caspase-3-dependent apoptosis in monocyte/macrophage life span: role of Hsp27. (Poster). 10th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2008 Malavez, Y., Voss, O.H., Doolittle, J., and Doseff, A.I. Regulation of apoptosis by PKCδ-dependent phoshorylation of caspase-3 (Poster). 10th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.



2008 Nicholas, C., Batra, S., Vargo, M.A., Voss, O.H., Gavrilin, M.A., Guttridge,D., Wewers, M.D. Grotewold, E., and Doseff, A.I. Apigenin induces apoptosis in leukemia, and the inflammatory response in vitro and in vivo through the inhibition of NF-κB-p65. (Poster). 10th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, Ohio.

Academic Advising

Additional Academic Advising includes:



i) Academic advising of a Research Associate 2012-1014. My role included planning of the daily experimental schedule, data interpretation and preparation of results for publication. I conducted weekly meetings and revised notebooks daily.



ii) Advising visiting scholars (9 since my last promotion). My roles include developing projects, helping students in setting experiments, analyzing data and interpreting results. I meet with trainees one to one weekly and during our weekly lab.



iii) Advising of STEM underrepresented undergraduate students (10 since my last promotion). I host students in my lab as part of three summer initiatives: the SROP OSU program, the Molecular Genetics-Biochemistry REU program and the SUCCESS program. My roles include developing projects, helping students to set experiments, analyze data, prepare data for presentations and developing critical thinking. In addition, I meet with them weekly one to one, I attend their oral, poster and journal club presentations, I meet with parents (SUCCESS program) and attend events such as dinners, banquets etc. I also revise their written projects and continue being in touch with most of them over the years.



iv) Advising SiGuE post-baccalaureate fellows (6 since my last promotion). My roles include developing projects, helping students in setting experiments, analyzing data and interpreting results. Developing opportunities to increase their self-esteem and provide orientation for application to graduate school or professional careers. I meet with trainees one to one weekly and during our weekly lab.



v) I advised a junior faculty Dr. Marketton (2009-2013)



vi) In my laboratory I advice postdocs, graduate and undergraduate students. My roles include conducting weekly meetings to discuss experiments, develop their projects, assisting in data analyses and preparation of data for presentations and publications. I provide advice in fellowship’s preparation and presentations (21 fellowships/scholarships and 27 awards for best presentations were obtained by my trainees since my last promotion).



vii) Advising graduate students in the Translational Plant Sciences program and serving as graduate studies committee (GSC) member. This is a different program characterized by a personalized curriculum. Students together with the GSC decide their minimum number of courses to take, meeting with the GSC are scheduled twice a year and presentations of students to the GSC take place at least once a year.

Continuing Education, Extension, and Other Courses Taught

2013 Atlas Genome Journal Club. Offered: January to May 2013, twice a month.

Students attending: 11

Content: knowledge of latest technologies used for genome-wide analysis including Gateway cloning, yeast one and two hybrid, introduction to software used in GWAS analyses and bioinformatics approaches to identify gene regulatory networks.

Contribution: I developed the curriculum. I presented 50% of all the 30 min. lectures and I was responsible of promoting and mediating the discussions. I selected the articles presented in class. The other 50% of the lectures were done by one of my postdocs as part of her career’s development plan.

Academic Advising

2006 - present Elaine Michelle, The Ohio State University. Regulation of caspase-3 by Hsp27
2008 - present S.J. Kolattukudy, The Ohio State University. Graduated 2006. The Role of Hsp27 in Human Monocyte Apoptosis
2008 - present M.E. Gonzalez-Mejia, The Ohio State University. Graduated 2006.
2008 - present S. , The Ohio State University. Graduated 2003.
2014 - present Duarte. S, The Ohio State University.
2002 - 2006 Kolattukudy, S.J, The Ohio State University. Title: The role of hsp27 in human monocyte apoptosis
2003 - 2006 Reno, E, The Ohio State University. Title: Regulation of caspase-3 by hsp27
2003 - 2006 Vargo, M., The Ohio State University. Graduated 2006. The anti-carcinogenic and anti-inflammatory mechanisms of the flavonoid apigenin
2005 - 2007 A Sharma, The Ohio State University.
2006 - 2008 Doolittle, J, The Ohio State University. Title: Mechanisms of the regulation of apoptosis
2006 - 2008 Vargo, M, The Ohio State University. Graduated 2008. The anti-carcinogenic and anti-inflammatory mechanisms of the flavonoid apigenin in mammalian cells
2004 - 2009 Speakman, J.J, The Ohio State University. Graduated 2009.
2005 - 2009 Nicholas, C, The Ohio State University. Graduated 2009. The anti-inflammatory mechanisms of the flavonoid apigenin in vitro and in vivo
2007 - 2009 Murnan, E, The Ohio State University. Title: Mechanisms of heat sock protein 27 in apoptosis
2004 - 2010 Voss, O.H, The Ohio State University. Graduated 2010. Regulation of apoptosis by caspase-3
2007 - 2010 Kamran, H, The Ohio State University. Title: Molecular mechanisms of caspase-3 dependent apoptosis
2009 - 2010 Yager-Schweller, J, The Ohio State University.
2010 Jennifer Hernandez, The Ohio State University.
2010 Margaret Apiagyei, The Ohio State University.
2010 Hector Cordero, The Ohio State University.
2009 - 2011 Hayes, S, The Ohio State University.
2009 - 2011 Brahimaj, B, The Ohio State University. Title: Molecular mechanisms of anti-carcinogenic flavonoids
2006 - 2012 Malavez, Y, The Ohio State University. Graduated 2012. Mechanisms of caspase-3 regulation in the execution of cell death
2007 - 2012 Greg Hostetler, The Ohio State University. Graduated 2012. Mechanisms of caspase-3 regulation in the execution of cell death
2011 - 2012 Pineda, C, National University of Columbia. Graduated 2013. Effects of the flavonoid apigenin in adipocyte differentiation and immune-response
2010 - 2013 Tossey, J, The Ohio State University. Title: Molecular Mechanisms of apoptosis resistance
2008 - 2015 Arango, D, The Ohio State University. Graduated 2015. The immune-modulatory and anti-carcinogenic mechanisms of the flavonoid apigenin
 

Chapters in Books

Doseff, A.I. and Parihar, A.. "Monocyte subsets and their role in tumor progression." In :Tumor Microenvironment and Myelomonocytic Cells. Edited by Dr. Subhra Biswas. -. ISBN: 978-953-51-0439-1: InTech, 43-62, January 2012.

Parihar, A., Grotewold, E., and Doseff, A.I.. "Flavonoids Dietetics: Mechanisms and Emerging Roles of Plant Nutraceuticals." In :Pigments in Fruits and Vegetables: Genomics and Dietetics. Edited by Dr. Chunxian Chen. -. N. Y.: Springer, March 2015.

 

Conferences

Doseff, A.I., Fahy, R.J., and Wewers, M.D.. "Spontaneous monocyte apoptosis and endotoxin protection are dependent on caspase-3 and do not require caspase-1 activity." In Faseb Journal. (March 1999). A519-A519.

Coulter, K.R., Doseff, A.I., and Knoell, D.L.. "Lung epithelial cells constitutively express caspase activity which is augmented by IL-1 and IFN-gamma." In Am. J. Respiratory and Critical Care Medicince. (March 1999). A907-A907.

Marsh, C.B., Graham, M.M., Doseff, A.I., and Kelley, T.W.. "M-CSF stimulates cell survival through an Akt dependent pathway: effects on caspase activation.." In J. Investigative Medicine. (August 1999). 258A-258A.

Parker-Barnes, J.M., Yee, J.F., Doseff, A.I., and Wewers, M.D.. "Isolation and characterization of I kappa B zeta, a new member of the I kappa B family: Interactions with IL-1 beta." In Faseb Journal. (March 2002). A1082-A1082.

Knoell, D.L., Sweeney, P., Wang, Y.J., Doseff, A.I., Chaudhuri, A., and Marsh, C.B.. "FGF-7 prevents Fas-mediated apoptosis in A549 human lung epithelial cells via activation of Akt kinase." In Faseb Journal. (March 2002). A677-A677.

Doseff, A.I., Voss, O.H., and Gonzalez-Mejia, M.E.. "The small Heat Shock Protein 27 regulates monocyte/macrophage survival and differentiation." In Am. J. Respiratoy Critical Care Medicine. (January 2009). 1358-.

Hostetler, G.L., Riedl, K.M., Cardenas, H., Diosa Toro, M., Schwartz, S.J., and Doseff, A.I.. "Deglycosylation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." In Faseb Journal. (April 2011). 000-.

Henkels, K.M., Frondorf, K., Gonzalez-Mejia, M.E., Doseff, A.I., Gomez-Cambronero, J.. "IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)." In FEBS LETTERS. (January 2011). 159-166.

Tossey, J., Voss, O.H., and Doseff, A.I.. "Molecular Ffingerprinting of Hsp27 anti-apoptotic activity." In Faseb Journal. (April 2012). 000-.

Arango, D., Morohashi, K., Yilmaz, A., Brahimaj, B., Kuramochi, K., Grotewold, E., and Doseff, A.I.. "Identification of human-flavonoid targets using an innovative approach reveals new mechanisms Involved in their anti-inflammatory activities." In Faseb Journal. (April 2012). 000-.

 

Editorial Activities

1997 - present Apoptosis
1999 - present Journal of Immunology
2003 - present Blood
2005 - present Journal of Biological Chemistry
2006 - present American Journal of Respiratory and Critical Care Medicine
2006 - present Cell Death and Differentiation
2006 - present Stem Cell and Development
2006 - present American Journal of Physiology
2006 - present Biochemical Pharmacology
2007 - present PlosOne
2008 - present Journal of Leukocyte Biology
2008 - present Journal of Lipid Research
2009 - present Cell Death and Disease
2010 - present Investigational New Drugs
2010 - present Frontier in Biosciences
2010 - present BBA-MCR (Molecular Cell Research)
2010 - present Frontier in Biosciences, Special Issue: Mechanisms of survival and cell death in leukocytes
2011 - present PlosOne Genetics
2011 - present Cell Biology and Toxicology
2012 - present Molecular Nutrition and Food Research
2012 - present Mutational Research
2012 - present Experimental Cell Research
2012 - present Current Nutrition and Food Science
2012 - present PlosOne Pathogens
2013 - present Phytotheraphy Research
2013 - present Journal Medicinal Food
2014 - present Nature Communications
2014 - present Journal of Medicinally Active Plants (JMAP)
2014 - present Pharmacology & Therapeutics (Impact Factor: 10)
2015 - present Cell Biochemistry and Biophysics
 

Honors

1988 - 1989 PhD Graduate Fellowship. Argentine National Research Council (CONICET), Argentina.
1996 - 1998 Postdoctoral Fellowship. National Institutes of Health.
1999 - 2001 Research Grant. American Lung Association.
2007 - present Nominated: OSU Distinguished Undergraduate Research Mentor of the Year. Ohio State University Undergraduate Program.
2013 - present Sphinx Mortar 24th Annual Faculty and Staff Recognition (nominated by an OSU undergraduate). Sphinx and Mortar Board Society.
2013 - present Nominated: OSU Distinguished Undergraduate Research Mentor of the Year. Ohio State University Undergraduate Program.
 

Journal Articles

Barneix, A.J., Doseff A.I., and Rodgers, C.O.. "Nitrate reductase activity In Argentine wheat cultivars." Cereal Research Communications. Vol. 16, no. 3-4. (January 1989.): 269-272.

Doseff, A.I., Martienssen, R., and Sundaresan, V.. "Somatatic excision of the MU1 transposable element of maize." Nucleic Acids Research. Vol. 19, no. 3. (February 1991.): 579-584.

Doseff, A.I. and Arndt, K.T.. "LAS1 is an essential nuclear protein invoved in cell morphogenesis and cell surface growth." Genetics. Vol. 141, no. 3. (November 1995.): 857-871.

Nestler, H.P. and Doseff, A.I.. "A two-dimensional, diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis technique to screen for protease substrates in protein mixtures." Analytical Biochemestry. Vol. 251, no. 1. (August 1997.): 122-125.

Fahy, R.J.#, Doseff, A.I.#, and Wewers, M.D.. "Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1." J. Immunology. Vol. 163, no. 4. (August 1999.): 1755-1762. # Indicates shared first author.

Kelley, T.W., Graham, M,M., Doseff, A.I., Pomerantz, R.W., Lau, S.M., Ostrowski, M.C., Franke, T.F., and Marsh, C.B.. "Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B." J. Biol. Chem. Vol. 274, no. 37. (September 1999.): 26393-26398.

Kirsch, D.G., Doseff, A.I., Chau, B.N., Lim, D., Souza-Pinto, N.C., Hansford, R., Kastan, M.B Lazebnik, Y. A., and Hardwick, J.M.. "Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c.." J. Biological Chemistry. Vol. 274, no. 30. (January 1999.): 21155-21161.

Coulter, K.R., Doseff, A.I., Sweeney, P., Wang, Y., Marsh, C.B., Wewers, M.D. and Knoell, D.L.. "Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells.." American Journal of Respiratory Cell and Molecular Biology. Vol. 26, no. 1. (January 2002.): 58-66.

Rovin, B.H., Wilmer, W.A., Lu, L., Doseff, A.I., Dixon, C., Kotur, M., and Hilbelink, T.. "15-Deoxy-Delta(12,14)-prostaglandin J(2) regulates mesangial cell proliferation and death." Kidney International. Vol. 61, no. 4. (April 2002.): 1293-1302.

Goyal, A., Wang, Y.J., Graham, M.M., Doseff, A.I., Bhatt, N.Y., and Marsh, C.B.. "Monocyte survival factors induce Akt activation and suppress caspase-3." American J. Respiratory Cell and Molecular Biology. Vol. 26, no. 2. (February 2002.): 224-230.

Doseff, A.I., Baker Jr., J.H., Bourgeois, T.A. and Wewers, M.D.. "IL-4-induced apoptosis entails caspase activation and dephosphorylation of ERK." Am. J. Resp. Cell and Mol. Biology. Vol. 269, (September 2003.): 367-374.

Zeigler, M.M., Doseff, A.I., Galloway, M.F., Opalek, J.M., Nowicki, P.T., Zweier, J.L., Sen, C.K., and Marsh, C.B.. "Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation." J. Biol. Chem. Vol. 278, no. 15. (April 2003.): 12894-12902.

Elssner, A., Doseff, A.I., Duncan, M., Kotur, M., and Wewers, M.D.. "Interleukin-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis.." J. Immunology. Vol. 172, no. 12. (January 2004.): 7721-7725.

Doseff, A.I.. "Apoptosis: the sculptor of development.." Stem cells and Development. Vol. 13, no. 5. (January 2004.): 473-483.

Wei, G., Guo, J., Doseff, A.I., Kusewitt, D.F., Man, A.K., Oshima, R.G., and Ostrowski, M.C... "Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.." J. Immunology. Vol. 173, no. 2. (January 2004.): 1374-1379.

Bao, S., Wang, Y., Sweeney, P., Chaudhuri, A., Doseff, A.I., Marsh, C.B., and Knoell, D.L.. "Keratynocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells.." American Journal of Physiology: Lung Cellular and Molecular Physiology. Vol. 288, no. 1. (January 2005.): L36-42.

Voss, O.H., Kim, S., Wewers, M.D., and Doseff, A.I.. "Caspase 3 is a phosphoprotein and associates with PKCδ during spontaneous monocyte apoptosis." J. Biol. Chem. Vol. 280, no. 17. (January 2005.): 17371-17379.

Vargo, M.A., Voss, O.H., Poustka, F., Cardounel, A.J., Grotewold, E., and Doseff, A.I. "Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells." Biochem. Pharmacology. Vol. 72, no. 6. (January 2006.): 681-692.

Nicholas, C., Batra, S., Vargo, M.A., Voss, O.H., Gavrilin, M.A., Wewers, M.D., Guttridge, D.C., Grotewold, E., and Doseff, A.I.. "Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NFκB through the suppression of p65 phosphorylation." J. Immunology. Vol. 179, (January 2007.): 7121-7127.

Voss, O.H., Batra, S., Kolattukudy, S.J., Gonzalez-Mejia, M.E., Smith, J.B., and Doseff, A.I.. "Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation." J. Biol. Chem.. Vol. 282, no. 34. (August 2007.): 25088-25099.

Malavez Y., Gonzalez-Mejia, M.E., and Doseff, A.I.. "PKCδ." Atlas Genet Cytogenet Oncol Haematol. Vol. 1, (January 2008.): 10-.

Gonzalez-Mejia, M.E., and Doseff, A.I.. "Regulation of monocytes and macrophages cell fate." Frontiers in Bioscience. Vol. 14, (January 2009.): 2413-2431.

Wood, K.L., Twigg III, H.L., and Doseff, A.I.. "Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation." Frontiers in Biosciences. Vol. 14, (January 2009.): 3771-3781.

Parihar, A., Eubank, T. and Doseff, A.I.. "Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death." J. Innate Immunity. Vol. 2, no. 3. (January 2010.): 204-215.

Wood, K.L., Nunley, D.R., Moffat-Bruce, S., Pope-Harman, A., Huang, Q., Shamo, E.N., Philips, G.S., Barna, C., Batra, S., Marsh, C.B., and Doseff, A.I.. "The role of Heat Shock Protein 27 in bronchiolitis obliterans syndrome after lung transplantation." J. Heart and Lung Transplantation. Vol. 29, (January 2010.): 786-791.

Pasupuleti, N., Matsuyama, S., Voss, O., Doseff, A.I., Song, K., Danielpour, D., and Nagaraj, R.H.. "The anti-apoptotic function of human alpha A-crystallin is directly related to its chaperone activity." Cell Death and Disease. Vol. 1, (March 2010.): e31-.

Gonzalez-Mejia, M.E., Voss, O.H., Murnan, E.J., and Doseff, A.I.. "Apigenin-induced-apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of Heat Shock Protein 27." Cell Death Disease. Vol. 10, (August 2010.): 1038-.

Wood, K.L., Voss, O.H., Huang, Q., Parihar, A., Metha, N., Batra, S., and Doseff, A.I.. "The small heat shock protein 27 is a key regulator of CD8+ CD57+ lymphocyte survival." J. Immunol.. Vol. 184, (January 2010.): 5582-5588. Selected for "In this issue" special editor's commentary.

Henkels, K.M., Frondorf, K., Gonzalez-Mejia, M.E., Doseff, A.I., Gomez-Cambronero, J.. "IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)." FEBS Letters. Vol. 585, no. 1. (January 2011.): 159-166.

Abdelaziz, D.H.A., Gavrilin, M.A., Akhter, A., Caution, K., Kotrange, S., Abu Khweek, A., Abdulrahman, B.A., Hassan, Zeinab, A., El-Sharkawi, F.Z., Bedi, S.S., Ladner, K., Gonzalez-Mejia, M.E., Doseff, A.I., Mostafa, M., Kanneganti, T-D., Guttridge, D., Marsh, C.B., Wewers, M.D., and Amer, A.O.. "Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages." Frontiers in Microbiology. Vol. 2, (January 2011.): 1-18.

Hostetler, G. Riedl, K., Cardenas, H., Diosa-Toro, M., Arango, D., Schwartz, S., and Doseff, A.I.. "Flavone deglycosylation increases their anti-inflammatory activity and absorption." Mol. Nutrit. Food Res.. Vol. 56, no. 4. (April 2012.): 558-569.

Akhter, A., Caution, K., Khweek, A.A., Tazi, M., Abdulrahman, B.A, Abdelaziz, D.H.A., Voss, O.H., Doseff, A.I., Hassan, H. Azad, A.K., Schlesinger, L.S., Wewers, M.D., Gavrilin, M.A., and Amer, A.O.. "Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization." Immunity. Vol. 37, no. 1. (July 2012.): 35-47.

Das, A., Gopalakrishnan, B., Voss, O.H., Doseff, A.I., and Villamena, F.A.. "Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling." Biochem. Pharmacol. Vol. 84, no. 4. (August 2012.): 486-497.

Arango, D., Parihar, A., Villamena, F.A., Wang, L., Freitas, M.A., Grotewold, E., and Doseff, A.I.. "Apigenin induces DNA damage through the PKCδ dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair." Biochem. Pharmacol.. Vol. 4, (January 2012.): 1571-1580.

Duarte, S., Arango, D., Yasmeen, R. Parihar, A., Hamel, P., and Doseff, A.I.. "Apigenin protects endothelial cells of LPS-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function." International J. Molecular Sciences. Vol. 14, (January 2013.): 17664-17679. #Indicates shared first authorship.

Arango, D., Morahashi, K., Yilmaz, A., Kuramichi, K., Parihar, A., Brahimaj, B., Grotewold, E., and Doseff, A.I.. "Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets." Proc. Natl. Acad. Sci. USA. Vol. 10, (May 2013.): 213-2162.

Naomi, R.B., Wang, B., Voss, O., Doseff, A.I., Santhoshkumar, P. and Nagaraj, R.H.. "Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization and opacification in experimental cataracts." J. Biol. Chem. Vol. 288, (January 2013.): 13022-13035.

Lakshmanan, A., Doseff, A.I., Ringel, M.D., Saji, M., Roussel, B., Zhang, X. and Jhiang, S.M.. "Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated readioiodide accumulation in thyroid cells." Thyroid. Vol. 24, (October 2014.): 878-887.

Casas, M.I., Duarte, S.M., Doseff, A.I.*, and Grotewold, E*.. "Flavone-rich maize: an opportunity to improve the nutritional value of an important commodity crop." Frontiers in Plant Sciences. Vol. 5, (September 2014.): 1-11. * Incates co.

Burdo, B., Gray, J., Goetting-Minesky, M.P., Wittler, B., Hunt, M., Li, T., Velliquette, D., Thomas, J., Gentzel, I., dos antos Brito, M., Mejia-Guerra, M.K., Connolly, L.N., Qaisi, D., Li, W., Casas, M.I., Doseff, A.I.,and Grotewold, E.. "The maize TFome - development of a transcription factor open reading frame collection for functional genomics." Plant Journal. Vol. 80, no. 2. (October 2014.): 356-366.

Arango, D., Diosa-Toro, M., Rojas-Hernandez, L.S., Cooperstone, J.L., Schwartz, S., Mo, X., Jiang, J., Schmittgen, T., Doseff, A.I. "Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation." Mol. Nutrit. Food Res.. Vol. 59, (January 2015.): 763-772.

Malavez, Y., Voss, O., Parihar, A., Gonzalez-Mejia, M.E. and Doseff, A.I.. "Distinct contribution of PKCδ and PKCe in the lifespan and immune response of human blood monocyte subpopulations." Immunology. Vol. 144, no. 4. (April 2015.): 611-620..

Parihar, A., Duarte, S., and Doseff, A.I.. "The saga of food supplements: safety and missing knowldege." J. Medical Active Plants. Vol. 2, (August 2015.): 12-.

Gray, J., Burdo, B., Goetting-Minesky, M.P., Wittler, B., Hunt, M., Li, T., Velliquette, D., Thomas, J., Key, K., Gentzel, I., dos Santos Brito, M., Mejia-Guerra, M.K., Connolly, L.N., Qaisi, D., Li, W., Casas, M.I., Doseff, A.I. Grotewold, E.. "Protocol for the generation of a transcription factor open reading frame collection (TFome)." BioProtocols. Vol. 5 (15), (July 2015.): e:1547-.

Ouma, W.,Z., Mejia-Guerra, M.,K., Yilmaz, A., Pareja-Tobes, P., Li, W., Doseff, A.I., and Grotewold, E.. "Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq)." Scientific Reports. Vol. 5, (March 2015.): 8635-.

 

Inventions and Patents

Doseff, A.I.: Swartz, Stephen; Hostetler, Gregory; Riedl, Ken; Cardenas, Horacio. "Processes for improving absorption and anti-inflammatory activity of dietary flavones." Filed January 2011.

Doseff, A.I.; Grotewold E.. "Inhibition of monocyte survival, differentiation or proliferation." Filed January 2005.

Doseff, A.I.; Wood, K.. "The small Heat shock protein 27 (Hsp27) is a marker for cellular life span." Filed September 2006.

 

Presentations

"Genetic screen to isolate genes involved in the function of SIT-4 phosphatiase." Presented at Meeting on Cell Cycle, Cold Spring Harbor, NY, US|USA. (January 1995)

"Delineating the caspase cascade by caspase depletion." Presented at Meeting on Programmed Cell Death, Cold Spring Harbor, NY, US|USA. (January 1997)

"Lung epithelial cells constitutively express caspase activity which is augmented by IL-1 and INF-gamma." Presented at American Thoracic Society International Conference, San Diego, CA, US|USA. (January 1999)

"The cyclopentenone prostaglandin 15-deoxy-delta^12,14-PGJ2{15dPGJ2} regulates human mesangial cell (HMC) proliferation and survival." Presented at ASN/ISN World Congress of Nephrology, San Francisco, CA, US|USA. (January 2000)

"Caspase activity in monocyte apoptosis." Presented at American Thoracic Society International Conference, Toronto, CA|CAN. (January 2000)

"Caspase-3 phosphorylation and its role in monocyte apoptosis." Presented at American Thoracic Society International Conference, Toronto, CA|CAN. (January 2000)

"Spontaneous monocyte apoptosis and endotoxin protection are dependent on caspase-3 and do not require caspase-1 activity." Presented at FASEB, Washington, DC, US|USA. (January 2000)

"Caspases: regulating by proteolysis the apoptotic cascade." Presented at American Thoracic Society International Conference, Toronto, CA|CAN. (January 2000)

"Dissecting the killing caspase cascade in human monocytes." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2000)

"Nitric oxide has a dual role in monocyte apoptosis via caspase-3 and the AKT-dependent pathway." Presented at FASEB, Orlando, FL, US|USA. (January 2001)

"Nitric oxide has a dual role in monocyte apoptosis via caspase-3." Presented at Research Conference, Pathology Department, Columbus, OH, US|USA. (January 2001)

"Monocyte survival induced by inflammatory cytokines and growth factors results from supression of caspase-3 activity in a PI 3-kinase dependent manner." Presented at American Thoracic Society International Conference, San Francisco, CA, US|USA. (January 2001)

"IL-4 induces apoptosis of activated monocytes through a caspase-dependent pathway." Presented at American Thoracic Society International Conference, San Francisco, CA, US|USA. (January 2001)

"Caspase-3 is a phosphoprotein and associates with a kinase that is modulated during monocyte activation and spontaneous monocyte apoptosis." Presented at Keystone Symposia, Keystone, CO, US|USA. (January 2001)

"Mechanisms of cell death." Presented at Internal Medicine Fellows Day, Columbus, OH, US|USA. (January 2001)

"Caspases: killer proteases inducing cell death." Presented at Molecular Biology and Cancer Genetics Program Conference, Columbus, OH, US|USA. (January 2001)

"MAIL gene is rapidly induced by LPS in monocytes but not in alveolar macrophages." Presented at American Thoracic Society International Conference, Atlanta, GA, US|USA. (January 2002)

"A bioinformatic approach to identifying new human apoptotic markers." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2002)

"Cardiak is a constitutively expressed in monocytes and interacts transiently with caspase-1 after endotoxon." Presented at FASEB, New Orleans, LA, US|USA. (January 2002)

"Killer caspases: The good guys in cancer and inflammation." Presented at Seminar Series, Columbus, OH, US|USA. (January 2002)

"Killer caspases: The executioners of apoptosis in cancer and inflammation." Presented at Winthrop-University Hospital, Mineola, NY, US|USA. (January 2002)

"Caspase-3 is a phsphoprotein that associates with and is phosphorylated selectively by a PKC isoform during monocyte lifespan." Presented at American Thoracic Society International Conference, GA, US|USA. (January 2002)

"Cardiak is constitutively expressed in monocytes and interacts transiently with caspase-1 after endotoxin." Presented at Keystone Symposia, Keystone, CO, US|USA. (January 2002)

"The apoptic machinery of monocytes is halted until caspase-3 is activated." Presented at Landacre, Columbus, OH, US|USA. (January 2002)

"IL-4 induces apoptosis of activated monocytes by inducing ERK dephosphorylation and reactivation of caspases." Presented at American Thoracic Society International Conference, WA, US|USA. (January 2003)

"Mitochondria depolarization is hastened by caspase-3 inhibitor during spontaneous monocyte apoptosis and is not required during Fas-induced monocyte apoptosis." Presented at American Thoracic Society International Conference, Seattle, WA, US|USA. (January 2003)

"An immunomagnetic based technology to quantify receptors presence and numbers on alveolar macrophages." Presented at American Thoracic Society International Conference, Seattle, WA, US|USA. (January 2003)

"Caspase-3 is a phosphoprotein that associates with and is phosphorylated selectively by a PKC during monocyte lifespan." Presented at American Thoracic Society International Conference, Seattle, WA, US|USA. (January 2003)

"When cells dye: pathways and approaches to study apoptosis." Presented at Sunrise Seminar, American Thoracic Society International Conference, WA, US|USA. (January 2003)

"Molecular mechanisms of apoptosis." Presented at Molecular and Cell Developmental Biology Program, The Ohio State University, OH, US|USA. (January 2003)

"Mechanisms of apoptosis in cancer and innate immunity." Presented at University of Buenos Aires, . (January 2003)

"Killer caspases: executing cell death by proteolysis." Presented at University of Buenos Aires, . (January 2003)

"Caspases: Regulating monocyte lifespan during innate immunity." Presented at The Heart and Lung Research Institute, The Ohio State University, OH, US|USA. (January 2003)

"Apoptotic proteases as executioners of unwanted cells." Presented at Human Cancer Genetics, The Ohio State University, OH, US|USA. (January 2003)

"The role of caspase-3 regulation in cell death of breast cancer cells." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2003)

"Identification of substrates of caspases in breast cancer cells by proteomics." Presented at Congreso Colombiano de Bioingenieria e Ingenieria Biomedica, Bogota. (January 2003)

"Caspase-3 phosphorylation by PKC-8 has a proapoptotic effect by increasing its activity and inhibition of PKC-8 induces prolonged human monocyte survival." Presented at American Thoracic Society International Conference, Orlando, FL, US|USA. (January 2004)

"Role of Hsp27 in the regulation of monocytes apoptosis." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2004)

"Hsp27 regulation in monocytes." Presented at Medical Center Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2004)

"Hsp27 regulates caspase-3 in monocytes." Presented at Undergraduate Colloquium, Columbus, OH, US|USA. (January 2004)

"The role of HSP in monocyte apoptosis." Presented at Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2004)

"Small heat shock proteins are differentially regulated and their localization varies during human monocyte apoptosis and prolonged survival." Presented at American Thoracic Society International Conference, Orlando, FL, US|USA. (January 2004)

"Regulation of monocyte life span y the interaction of hsp27 with caspase-3." Presented at Biennial Retreat Molecular Biology and Cancer Genetics Program, Atwood, OH, US|USA. (January 2005)

"Caspase-3 phosphorylation by PKC-8 has a proapoptotic effect." Presented at Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2005)

"Caspase-3 phosphorylation by PKC-8 has a proapoptotic effect." Presented at Medical Center Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2005)

"The flavonoid apigenin is a potent inducer of apoptosis in monocytic leukemias." Presented at Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2005)

"Flavonoids: anti-cancer and anti-inflammatory compounds." Presented at Therapeutic Team, Department of Internal Medicine, The Ohio State University, OH, US|USA. (January 2005)

"Caspases controlling life and death in cancer and immunity." Presented at Department of Molecular Genetics, The Ohio State University, OH, US|USA. (January 2005)

"Apoptosis." Presented at Basic Research Conference, Div. Pulmonary and Critical Care, The Ohio State University, OH, US|USA. (January 2005)

"Interaction of Hsp27 and PKC-8 with caspase-3 regulates monocyte life span." Presented at The 5th Annual Comprehensive Cancer Center Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2006)

"Apigenin-induced apoptotic release of histones H2B and H4 to the cytoplasm." Presented at The 1st Annual Pulmonary Critical Care, Allergy and Sleep Research Day, Columbus, OH, US|USA. (January 2006)

"Regulation of caspase-3 via PKC-8 phosphorylation." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2006)

"Regulation of cell death by phosphorylation of caspase-3." Presented at The Ohio Student Research Forum, Columbus, OH, US|USA. (January 2006)

"Regulation of programmed cell death: implications for cancer and inflammation." Presented at Graduate Program in Oral Biology Seminar Series, The Ohio State University, US|USA. (January 2006)

"Executioners caspases controlling life and death in cancer and immunity." Presented at University of Buenos Aires, Buenos Aires, AR|ARG. (January 2006)

"Apoptosis: sculptor of development." Presented at Meeting for Gynecologic Investigation, Toronto, CA|CAN. (January 2006)

"Monocyte Life Span by the Interaction of Hsp27 and PKC 8 with Caspase -3.." Presented at International Conference, San Diego, CA, US|USA. (January 2006)

"Regulation of apoptosis by caspase-3 mediated by Hsp27 and PKC-8." Presented at The 8th Annual Comprehensive Cancer Center Scientific Meeting, Columbus, OH, US|USA. (January 2006)

"Interaction of Hsp27 and PKC-8 with caspase-3 regulates monocyte life span." Presented at 5th Anniversary Celebrations of the Heart and Lung Research Institute, Columbus, OH, US|USA. (January 2006)

"Heat Shock Protein 27 regulates monocyte life span by inhibiting caspase-3 activation." Presented at 1st Annual Pulmonary, Critical Care, Allergy and Sleep Research Day, Columbus, OH, US|USA. (January 2006)

"Monocyte Life Span by the Interaction of Hsp27 and PKC-8 with Caspase-3." Presented at American Thoarcic Society International Conference, San Diego, CA, US|USA. (January 2006)

"The role of HSP27 and PKC as regulators of caspase-3 during apoptosis." Presented at The 1st Annual Pulmonary, Critical Care, Allergy and Sleep, Research Day, Columbus, OH, US|USA. (January 2006)

"The flavonoid apigenin regulates the production of inflammatory cytokines by promoting the dephosphorylation and inactivation of NF-kB in LPS stimulated monocytes." Presented at The 1st Annual Pulmonary Critical Care, Allergy and Sleep Research Day, Columbus, OH, US|USA. (January 2006)

"Regulation of cell fate: the caspases attack." Presented at Miami University, Oxford, OH, US|USA. (January 2007)

"Regulation of apoptosis: implications for cancer and innate immunity." Presented at The Cleveland Clinic, Cleveland, OH, US|USA. (January 2007)

"PKC8 dependant phosphorylation of caspase-3 and its association with Hsp27 regulate monocyte life span." Presented at Cell Death Meeting, Cold Spring Harbor, NY, US|USA. (January 2007)

"Heat Shock Protein 27 regulates monocyte life span by inhibiting caspase-3 activation.." Presented at American Thoracic Society International Conference, San Francisco, CA, US|USA. (January 2007)

"The flavonoid apigenin suppresses acute lung injury. (Oral Presentation)." Presented at Interdisciplinary Graduate Programs Symposium, Columbus, OH, US|USA. (January 2007)

"Regulation of apoptosis by heat shock proteins and PKC." Presented at Case Western Reserve University, Cleveland, OH, US|USA. (January 2008)

"Anti-inflammatory and anti-carcinogenic mechanisms of plant natural products." Presented at Pan-American Advance Studies Institute (PASI), PE|PER. (January 2008)

"The role of Heat shock protein 27 in Bronchiolitis obliterans after lung transplantation." Presented at American Thoracic Society International Conference, Ontario, CA|CAN. (January 2008)

"Natural immune-regulators: alternative therapeutic approaches in acute lung injury." Presented at Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2009)

"Caspase-3 phosphorylation is mediated by the association of PKC and Hsp27 during apoptosis." Presented at The 3rd Annual Davis Heart and Lung Research Institute Research Retreat, Columbus, OH, US|USA. (January 2009)

"Apigenin induces DNA damage in a PKC-dependent manner." Presented at The 3rd Annual Davis Heart and Lung Research Institute Research Retreat, Columbus, OH, US|USA. (January 2009)

"Determination of cellular life span through the intearction of caspase-3 with PKC and Hsp27." Presented at The 3rd Annual Davis Heart and Lung Research Institute Research Retreat, Columbus, OH, US|USA. (January 2009)

"Regulation of cell fate by PKCd-dependent phosphorylation of caspase-3 and its association with Hsp2." Presented at Falkenthal Memorial Graduate Student Colloquium, Columbus, OH, US|USA. (January 2009)

"The small heat shock protein 27 regulates monocyte/macrophage survival and differentiation." Presented at American Thoracic Society International Conference, San Diego, CA, US|USA. (January 2009)

"Regulation of cell fate in leukocytes." Presented at National Academy of Medicine, Buenos Aires, AR|ARG. (August 2010)

"Celery extracts induce invitro inhibition of NF-?B activity and TNFa production in LPS-stimulated macrophages." Presented at 5th Annual Research Day, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Determination of cellular life span from cells of the innate and adaptive immune system by the heat shock protein 27." Presented at The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day., Columbus, OH, US|USA. (January 2010)

"Hsp27 determines cell fate of cells from the innate and adaptive immune system by regulating the activation of caspase-3." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Monocytes and macrophages life span is regulated by the association of caspase-3 with Hsp27." Presented at The 10th Annual Dorothy M. Davis Heart and Lung Research Institute Day, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at The 10th Anniversary, Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory activity of foodsxtracts in vitro and absorption of dietary flavones from celery in a mouse model." Presented at The 7th Annual Russell Klein Nutrition Research Symposium, Columbus, OH, US|USA. (January 2010)

"Protective effect of apigenin against mortality induced by acute inflammation in mice is associated with reducition on MIP-2 chemokine expression and lung nutrophil infiltration." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"The anti-inflammatory flavonoid apigenin reduces mortality in a mouse model of acute inflammation by inhibiting lung neutrophil infiltration and reducing MIP-2 chemokine expression." Presented at The Davis Heart and Lung Research Day, Columbus, OH, US|USA. (January 2010)

"Apigenin reduces mortality in a mouse model of acute lung injury by inhibiting neutrophil infiltration, MIP-2, and apoptosis in the lungs." Presented at 12th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-3-PKC-dependent phosphorylation in apoptosis." Presented at Biological, Mathematical, and Physical Sciences Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-3-PKC-dependent phosphorylation in apoptosis." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Anti-proliferative mechanisms of the flavonoid apigenin." Presented at 12th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2010)

"Anti-carcinogenic mechanisms of the plant flavonoid apigenin." Presented at The 24th Annual Summer Research Opportunities Program Conference, Columbus, OH, US|USA. (January 2010)

"Anti-carcinogenic mechanisms of the plant flavonoid apigenin." Presented at The 7th Annual Russell Klein Nutrition Research Symposium, Columbus, OH, US|USA. (January 2010)

"Modulation of caspase-3 enzymatic activity by PKC phosphorylation during apoptosis." Presented at The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2010)

"PKCo phosphorylation of caspase-3 promotes apoptosis through a complex regulatory network." Presented at The 10th Anniversary, Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2010)

"Phosphorylation of caspase-3 regulates apoptosis through a complex regulatory network." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Role of PKCo dependent phosphorylation of caspase-3 on programmed cell death." Presented at The Interdisciplinary Graduate Programs Symposium in the Molecular Life Sciences (MCDB, OSBP, and Biophysics), Columbus, OH, US|USA. (January 2010)

"Phosphorylation of Hsp27 reduces its association with caspase-3 inducing monocyte apoptosis." Presented at The 5th Annual Research Day, Davis Heart and Lung Research Institute Research Say, Columbus, OH, US|USA. (January 2010)

"Apigenin-induced a bimodel phosphorylation of heat shock protein 27 via p38-MAPK and PKC regulates mitochondrial depolarization during apoptosis." Cold Spring Harbor, NY, US|USA. (January 2010)

"Target identification of the flavonoid apigenin: implications fortis anti-inflammatory activity." Presented at The 10th Anniversary, Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory mechanism of the flavonoid apigenin." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-dependent apoptosis." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-dependent apoptosis." Presented at Biological, Mathematical, and Physical Sciences Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Mapping the heat shock protein 27 peptide motif responsible for the inhibition of caspase-3 apoptotic activity." Presented at 24th Annual Summer Research Opportunities Program (SROP) Confrence, Columbus, OH, US|USA. (January 2010)

"Mechanisms of cell fate during inflammation of cancer." Presented at Department of Pharmacology, Columbus, OH, US|USA. (January 2010)

"Association of caspase-3 with heat shock protein 27 regulates cellular life span of cells from the innate and adaptive immune system." Presented at Cell Death Meeting, Cold Spring Harbor, NY, US|USA. (October 2010)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at 13th Annual OSU Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at 10th Annual Ohio State University Medical Center, Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (April 2011)

"Innovative approach towards anti-inflammatory apigenin target identification." Presented at 4th Annual translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (April 2011)

"Caspases and heat shock proteins: inflammation tuning by cell death." Presented at The Davis Heart and Lung Research Institute, Columbus, Ohio. (November 2011)

"Regulation of apoptosis: implications for cancer and innate immunity." Presented at Stony Brook University, Stony Brook, NY, US|USA. (April 2011)

"Molecular mechanisms of anti-carcinogenic flavonoids." Presented at Natural and Mathematical Sciences Undergraduate Research Fourm, . (April 2011)

"Molecular mechanisms of anti-carcinogenic flavonoids." Presented at Denman Undergraduate Research Forum, . (May 2011)

"The role of plant small metabolite in the regulation of adipocytokine secretion and hypertrophy." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"Innovative approach towards understanding the anti-inflammatory mechanisms of the flavonoid apigenin." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"PD-Seq:Coupling phage-display with next-generation sequencing towards the identification of human cellular targets of the flavonoid apigenin and development of flavonoids nanosensors." Presented at Gordon Conference-Plant Metabolic Engineering, Waterville Valley, NH, US|USA. (July 2011)

"Role of Hsp27 in monocyte to macrophage life span and differentiation." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"Deglycosylation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at The 8th annual Russell Klein Nutrition Research Symposium, . (January 2011)

"Molecular identification of Hsp2 anti-apoptotic activity." Presented at Denman Undergraduate Research Forum, . (February 2011)

"Molecular identification of Hsp2 anti-apoptotic activity." Presented at Natural and Mathmatical Sciences Undergraduate Research Forum, . (April 2011)

"Molecular fingerprinting of Hsp27 anti-apoptotic activity." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"PKCo regulated cell death and survival through phosphorylation of caspase-3." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"Caspases and heat shock proteins: inflammation tuning by cell death." Presented at The Davis Heart and Lung Research Institute, Columbus, OH, US|USA. (July 2011)

"The anti-inflammatory flavonoid apigenin reduces mortality in a mouse model of acute inflammation by inhibiting lung neutrophil infiltration and reducing MIP-2 chemokine expression." Presented at The 10th Anniversary Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2011)

"Molecular biosensor of flavonoids involved in regulation of inflammation." Presented at 4th Annual Translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (January 2011)

"Heat shock proteins and caspases in the regulation of cell fate and immunity." Presented at Tel-Aviv University, Tel-Aviv, IL|ISR. (March 2011)

"Anti-cancer and anti-inflammatory molecular mechanisms of dietary plant flavonoids." Presented at Interdepartmental Seminar in Nutrition, Columbus, OH, US|USA. (April 2011)

"The cellular fate of monocytes and macrophages is regulated by Hsp27." Presented at 4th Annual Translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (January 2011)

"Monocytes and macrophages life span is regulated by the association of caspase-3 with Hsp27." Presented at The 10th Anniversary Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2011)

"Hsp27 determines the cellular life span of monocytes and macrophages." Presented at The 10th Annual Ohio State University Medical Center, Graduate and Post-Graduate Research Day, Columbus, OH, US|USA. (January 2011)

"PKCo-dependent phosphorylation of caspase-3 modulates its enzymatic activity and cell death." Presented at 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Deglycosilation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Deglycosilation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorbtion of dietary flavones from celery in mice.." Presented at Experimental Biology, Washington, DC, US|USA. (January 2011)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at The 10th Annual Ohio State University Medical Center, Graduate and Post-Graduate Research Day, Columbus, OH, US|USA. (January 2011)

"Innovative approach towards anti-inflammatory apigenin target identification." Presented at 4th Annual Translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (January 2011)

"Two to Tango: heat shock proteins and caspases in the regulation of cell fate." Presented at Department of Molecular Genetics, Columbus, OH, US|USA. (February 2011)

"Plants for health: from education and research to the clinic." Presented at Flora Braziliensis, Columbus, OH, US|USA. (February 2012)

"Role of caspase-3 in cell fate: novel partners define a complex regulatory network." Presented at International Cell Death Symposium, BR|BRA. (October 2012)

"Plants for health: regulatory networks controlling inflamation and cancer." Presented at University of Mayaguez, PR|PRI. (November 2012)

"Flavonoids-target identification and development of biosensors." Presented at B3 Tripartite OSU-Rutgers-Univeristy of Sao Paulo, Columbus, OH, US|USA. (May 2012)

"Effect of apigenin on metabolic dysfunction in adipose tissue." Presented at OSU-Comprehensive Cancer Center Annual Scientific Meeting, . (March 2012)

"Target identificaiton and anti-carcinogenic mechanisms of dietary flavonoids." Presented at The 14th OSU-Comprehensive Cancer Center Annual Scientific Meeting, . (March 2012)

"Anti-apoptotic proteins: essential regulators of monocyte to macrophage life span and differentiation." Presented at The Davis Heart and Lung Institute Research Day, . (October 2012)

"Identification of human-flavonoid targets using an innovative approach reveals new mechanisms involved in their anti-inflamatory activities." Presented at Experimental Biology, . (April 2012)

"Target identification and regulation of innate immunity by the dietary flavonoid apigenin." Presented at Annual Scientific Meeting, . (April 2012)

"Effect of apigenin on metabolic dysfunction in adipose tissue." Presented at The 9th Annual Russell Nlein Nutrition Research Symposium, . (May 2012)

"Heat shock proteins and apoptotic caspases define complex survival and apoptotic regulatory networks controlling cell fate and inflammation." Presented at Northeast Ohio Medical University, OH, US|USA. (September 2012)

"Role of anti-apoptopic proteins in monocyte to macrophase life span and differentiation." Presented at The 11th Annual Ohio State University Medical Center, Graduate, Undergraduate and Postgraduate Research Day, . (April 2012)

"Molecular Fingerprinting of Hsp27 Anti-Apoptotic Activity." Presented at Experimental Biology, San Diego, CA. (April 2012)

"Moleculat identification of Hsp27 Anti-Apoptotic Activity." Presented at Denman Undergraduate Research Forum, . (April 2012)

"The role of apigenin and Hsp27 in NSCLC apoptosis." Presented at The Davis Heart and Lung Institute Research Day, . (October 2012)

"Identification of target genes regulated by the shine transcription factor in monocot plants using CHIP-Seq." Presented at Gordon Conference, NH, US|USA. (July 2013)

"Identification of human targets of the dietary flavone apigenin reveals novel aspects of the anti-carcinogenic and anti-inflammatory mechanisms of phytochemicals." Presented at Gordon Conference-Plant Metabolic Engineering, Waterville Valley, NH, US|USA. (July 2013)

"Mechanisms of breast cancer chemosensitization by dietary compounds SUCCESS program." Presented at The Ohio State University, Columbus, Ohio. (August 2013)

"Complex regulatory interactions of survival and apoptotic proteins determine cell fate by tuning caspase activity." Presented at University of Sao Paulo, Brazil, Sao Paulo, BR|BRA. (April 2013)

"MALCS (Mujeres Activas en Letras y Cambio Social: Women active in social studies and languages) – STEM session." Presented at Bridging the Gap: underrepresented groups in STEM, Columbus, OH, US|USA. (July 2013)

"Regulation of casapse-3 by the anti-apoptotic proteins XIAP and Hsp27." Presented at SROP, Columbus, Ohio. (July 2013)

"Using the yeast of two-hybrid systems to determne caspase-3 prodomian interaction with hsp27." Presented at REU-Molecular Genetics/Biochemistry, Columbus, Ohio. (August 2013)

"Anti-apoptopic proteins: essential regulators of monocyte to macrophage life span and differentiation." Presented at The 12th Annual Ohio State University Medical Center, Graduate and Postgraduate Trainee Research Day, . (April 2013)

"The role of apigenin and Hsp27 in NSCLC apoptosis." Presented at Denman Undergraduate Research Forum, . (April 2013)

"The identification of regulatory networks that control phenolic biosynthesis in maize." Presented at 55th Annual Maize Genetics Conference, . (March 2013)

"Approaches to identify gene regulatory networks in grasses." Presented at 55th Annual Maize Genetics Conference, . (March 2013)

"Target identification of Dietary Flavonoids Reveals Novel Mechanisms Involved in Their Anti-Carcinogenic Activity." Presented at The 10th Annual Russel Klein Nutrition Research Symposium, . (March 2013)

"1st Place Graduate Student Category." Presented at The 12th Annual Ohio State University Medical Center, Graduate and Postgraduate Trainee Research Day, . (April 2013)

"Identification of human targets of the dietary flavone apigenin reveals novel aspects of the anti-carcinogenic and anti-inflammatory mechanisms of phytochemicals." Presented at Gordon Conference-Plant Metabolic Engineering, Waterville Valley, NH, US|USA. (July 2013)

"Mechanisms and functional significance of bioactive food components in mitochondrial dysfunction: potential new translational approaches in inflammation-induced metabolic disorders." Presented at The 12th Annual Ohio State University Medical Center, Graduate and Postgraduate Research Day, . (April 2013)

"The role of apigenin and Hsp27 in NSCLC apoptosis." Presented at Natural and Mathematical Sciences Undergraduate Research Forum, . (April 2013)

"Survival and apoptotic networks regulate cellular lifespan." Presented at Department of Molecular Genetics, Columbus, OH, US|USA. (September 2013)

"Dietary flavonoids: targeting cancer and inflammation." Presented at Department of Horticulture and Crop Sciences, Columbus, OH, US|USA. (November 2013)

"MALCS (Mujeres Activas en Letras y Cambio Social: Women active in social studies and languages) – STEM session." Presented at Bridging the Gap: underrepresented groups in STEM, Columbus, OH, US|USA. (July 2013)

"Survival and apoptotic regulatory networks: implications for cancer and inflammation." Presented at Department of Physiology and Cell Biology, Columbus, OH, US|USA. (May 2014)

"Novel mechanisms of dietary medicinal phytochemicals identified through a comprehensive genome-wide approach: implications for cancer and inflammation." Presented at American Council for Medically Active Plants, Fargo, ND, US|USA. (June 2014)

"Protein networks in cellular life span: implication for cancer and inflammation." Presented at Chemistry and Biology Interface Training Program (CBIP), Columbus, OH, US|USA. (October 2014)

"Human targets of dietary flavonoids identified using a novel approach PD-Seq. reveals novel aspects of the anti-carcinogenic and anti-inflammatory mechanisms of phytochemicals." Presented at The 8th Tripartite Workshop, Rutgers University, University of São Paulo, Brazil, and The Ohio State University, NJ, US|USA. (November 2014)

"Cel-KIBCAN: celery to kill breast cancer." Presented at Translational Breast Meeting, Columbus, OH, US|USA. (February 2015)

 

Professional Activities

present Presentation for Girl Scouts: Science and the Future. Title Presentation: Around the world, education has no limits.. Columbus, OH.
present Upper Arlington High School Science Fair. Columbus, OH.
present Upper Arlington High School Science Fair. Columbus, OH.
2013 - present Chair Basic Cell and Molecular Biology Study Section. American Heart Association. Columbus, OH.
2001 - 2005 American Thoracic Society - Allergy and Immunology Assembly Program Organizer.
2007 - 2008 American Heart Association-Great Rivers Valley Area.
2008 Rutgers University. Hatch Proposals, New Jersey Agricultural experimental Station, Rutgers University.
2007 - 2009 Davis Heart & Lung Research Institute.
2009 Dr. Patricia Finn. University of California. San Diego, CA.
2009 National Science Foundation. Molecular Cellular Biology-Panel II Cellular Signalling.
2009 Denman Undergraduate Research Forum. The Ohio State University. Columbus, OH.
2009 National Institute of Health. Lung Cellular, Molecular, and Immunobiology Study Section.
2010 The 10th Anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University. Columbus, OH.
2010 Dr. Robert Schleimer. Northwestern University. Chicago, IL.
2010 Dr. David Dockrell. University of Sheffield.
2010 Dr. Vincent Cryns. Northwestern University. Chicgo, IL.
2010 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine. The Ohio State University. Columbus, OH.
2011 4th Annual Translational to Clinical (T2C) Wound Care Conference. The Ohio State University Medical Center. Columbus, OH.
2011 Medical Center Research Day. The Ohio State University. Columbus, OH.
2011 Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University. Columbus, OH.
2011 Denman Undergraduate Research Forum. The Ohio State University. Columbus, OH.
2011 Dr. Johaness Tesfaigzi. Lovelace Respiratory Research Institute. Albuquerque, NM.
2011 The Davis Heart and Lung Research Day. The Ohio State University. Columbus, OH.
2006 - 2012 Division of Pulmonary and Critical Care.
2012 National Institute of Health. Study Section ZRG1 F09-P 20 L.
2012 National Science Foundation. Integrative Organismal Biology.
2012 Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University. Columbus, OH.
2012 Dr. Gustavo Amarantes-Mendes. University of São Paulo.
2012 Denman Undergraduate Research Forum. The Ohio State University. Columbus, OH.
2012 National Institute of Health. Lung Cellular, Molecular, and Immunobiology Study Section.
2012 Presentation: Opportunities for graduate education in STEM disciplines. University of Puerto Rico. Mayaguez, PR.
2012 The Davis Heart and Lung Research Day. The Ohio State University. Columbus, OH.
2008 - 2013 Co-Chair Basic Cell and Molecular Biology Study Section. American Heart Association.
2013 Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University. Columbus, OH.
2013 Upper Arlington High School Science Fair. Columbus, OH.
2014 Davis Heart and Lung Research Institute Research Day. The Ohio State University. Columbus, OH.
2014 College of Medicine Research Day. The Ohio State University. Columbus, OH.
2014 Upper Arlington High School Science Fair. Columbus, OH.
2014 Building research leaders: Gender initiatives in STEM, Project CEOS and the Women’s place. Presentation: Finding your faculty career niche.. The Ohio State University. Columbus, OH.
2014 Denman Undergraduate Research Forum. The Ohio State University. Columbus, OH.
2015 Physiology and Cell Biology Research Day. The Ohio State University. Columbus, OH.
2015 Career development panel discussion for undergradaute students in the SUCCESS program. The Ohio State University. Columbus, OH.
 

Unpublished Works

Arango, D., Mejia-Guerra, K., Grotewold, E., and Doseff, A.I. Genome-wide regulation of alternative splicing by dietary apigenin controls anti-apoptotic-associated resistance in breast cancer.. March 2015.

Cardenas, H.*, Arango, D.*, Nicholas, C., Duarte, S., Gonzalez-Mejia, E., Nuovo, G., Grotewold, E., and Doseff, A.I.. Dietary apigenin regulates lipopolysaccharide-induced pulmonary inflammation by restoring metabolic function and reducing leukocyte infiltration. *Indicates shared first authorship.. June 2015.

Voss, O., Tossey, J., Arango, D., Grotewold, E., and Doseff, A.I. Chemo-sensitization of lung cancer by dietary apigenin through changes in alternative splicing promoting the activation of DISC formation.. May 2015.

Gonzalez-Mejia, E., Voss, O.H., and Doseff, A.I. Phosphorylation of Hsp27 during apoptosis mediates PKCo-dependent phosphorylation of caspase-3. February 2015.

Mejia-Guerra, K., Li, Wei, Doseff, A.I.# and Grotewold, E.#. Core promoter plasticity between maize tissues and genotypes contrasts with predominance of sharp transcription initiation sites. # Indicates shared senior corresponding author. July 2015.

Voss, O.H., Malavez, Y., and Doseff, A.I. Specific docking sites of PKCδ on caspase-3 induce phosphorylation and positively regulates apoptosis.. July 2015.

Arango, D., Pereira, M., Duarte, S., and Doseff, A.I. NFkB-dependent regulation of proliferative and immune-regulatory activity of dietary apigenin in breast cancer. August 2015.