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Andrea Doseff, PhD


Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-8987

Email: doseff.1@osu.edu

 

Current OSU Appointments

Associate Professor, Molecular Genetics Admin

Associate Professor, SBS-Physiology & Cell Biology

 

Biographical

Andrea I. Doseff, Ph.D. is an Associate Professor with tenure in the Department of Molecular Genetics and the Departmentof Physiology and Cell Biology at The Ohio State University. Dr. Doseff received her bachelor’s degree from University of Buenos Aires, Argentina and her PhD from Cold Spring Harbor Laboratory in New York working in cell cycle regulation. She completed her postdoctoral training in apoptosis. Dr. Doseff joined The Ohio State University as an Assistant Professor in 2002 and currently leads a multidisciplinary team of scientists who focus on understanding how cells die. Her group is especially interested in elucidating the molecular mechanisms that control cell fate in the immune system. In addition, her group investigates the anti-inflammatory and anti-carcinogenic mechanisms of flavonoids. Her findings have been published in Genetics, Journal of Biological Chemistry, Biochemical Pharmacology, and Journal of Immunology among others. She serves as a reviewer for several journals. She serves on National Institute of Health, National Science Foundation study sections and she is a co-chair of the American Heart Association study section. She has an active teaching program funded by NSF, NIH , AHA, and grants for education and training from NSF and NIH.

Advising Narrative

Undergraduate students with honor research thesis

Tossey, J., BS Summer 2010- May 2013 B.Sc. with Distinction, OSU

Title thesis: Molecular Mechanisms of apoptosis resistance

Currently: University of Kentucky – Pharmacy



Cristina Sarmiento Spring 10-2012 Honor Student Biology



Brahimaj, B., BS Summer 2009- May 2011 B.Sc. with Distinction, OSU

Title thesis: Molecular Mechanisms of anti-carcinogenic Flavonoids

Currently: University of Cincinnati Medical School



Kamran, H., BS 2010 B.Sc. with Distinction, OSU

Title thesis: Molecular mechanisms of caspase-3 dependent apoptosis

Currently: Baylor School of Medicine



Murnan, E., BS 2009 B.Sc. with Distinction, OSU

Title thesis: Mechanisms of heat sock protein 27 in apoptosis

Currently: Dental school The Ohio State University



Doolittle, J.M., BS 2008 B.Sc. with Distinction, OSU

Title thesis: Mechanisms of the regulation of apoptosis

Currently: University of North Carolina, PhD program in System Biology



Reno, E, BS 2006 B.Sc. with Distinction, OSU

Title thesis: Regulation of Caspase-3 by Hsp27



Kolattukudy, S.J.,BS 2006 B.Sc. with Distinction, OSU

Title thesis: The Role of Hsp27 in Human Monocyte Apoptosis



Arts and Sciences Research Fellowship 2014-2015

Shao, Q. (student) Doseff, A.I. (Mentor)

Total Award: $2,000



Arts and Sciences - Thomas Byers Memorial Fellowship 2013-2014

Rice, E. (student) Doseff, A.I. (Mentor)

Total Award: $2,000



Comprehensive Cancer Center-Pelotonia undergraduate fellowship 2012-2013

Tossey, J. (student) Doseff, A.I. (Mentor)

Title: The role of flavones in Hsp27-regulated apoptosis in non-small cell lung carcinomas

Total Award: $14,000



Arts and Sciences Honor Undergraduate Research Scholarship 2011-2012

Tossey, J. (student) Doseff, A.I. (Mentor)

Title: Regulation of cell death by the small heat shock protein 27

Total Award: $7,000



American Heart Association Undergraduate Fellowship Summer 2011

Tossey, J. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of the Anti-Apoptotic Heat Shock Protein 27 in Doxorubicin-induced Cardiomyocyte Apoptosis

Total Award: $4,000



Undergraduate Student Government Academic Enrichment Grant, Travel Award April 2012

Tossey, J. (student) Doseff, A.I. (Mentor)

Total Award: $1,000 to attend the Experimental Biology Meeting



Pressey Honors Grant

Competitive award provides funds to attend a conference. Experimental Biology 2012

Tossey, J. (student) Doseff, A.I. (Mentor)

Total Award: $300



Sharp undergraduate scholarship 2009

Kamran, H. (student) Doseff, A.I. (Mentor)

Total Award: $1,000



The Mayers Summer Research Internship Award Summer 2009

Kamran, H. (student) Doseff, A.I. (Mentor)

Title: Molecular regulation of caspase-3

Total Award: $4,000



The Mayers Summer Research Internship Award Summer 2008

Murnan, E. (student) Doseff, A.I. (Mentor)

Title: Role of heat shock proteins in cell death

Total Award: $4,000



The Mayers Summer Research Internship Award Summer 2007

Doolittle, J. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of the regulation of apoptosis: mathematical and system biology

Total Award: $4,000



Glenn-Stokes Summer Research Internship at OSU Summer 2007

The student is from University of Dayton

Arasu, M. (student) Doseff, A.I. (Mentor)

Title: Pathways of cell fate

Total Award: $4,500



The Mayers Summer Research Internship Award Summer 2004

Reno, E. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of caspase-3 regulation by hsp27.

Total Award: $3,000



Arts & Sciences Undergraduate Research Scholarship Winter 2003

Vargo, M. (student) Doseff, A.I. (Mentor)

Title: The role of caspase-3 regulation in cell death of breast cancer cells

Total Award: $1,000



OSU-CCC Summer Internship Program Summer 2002

Sancaktar, O. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of FAS-dependent apoptosis

Total Award: $2,500 and Travel Award for meeting



Undergraduate Enrichment Fund from College of Biological Sciences Spring 2004

Kolattukudy, S.J. (student) Doseff, A.I. (Mentor)

Title: Mechanisms of caspase-3 and hsp27 in apoptosis.

Total Award: $300



Dean’s College of Biological Sciences Undergraduate Research Award

Kamran, H., Winter 2010

Kamran, H., Winter 2009

Kamran, H., Fall 2008

Murnan, E., Wi 2008

Doolittle, J., Au and Wi 2007

Taylor, C., Wi 2006

Kollatukudy, S.J. Wi 2004

Reno E., Fall 2004

Vargo, M., Sp 2002



Total Award in each case: $300



Undergraduate Students and post-baccalaureate Awards for Best Poster and Presentations (* indicates undergraduate and # indicates post-baccalaureate; 6 since the last promotion)

2015 Alers Velazquez, R.M., Li, W., Valentin Morales, J., Prada Salcedo, L.D., Gray, J., Grotewold, E., and Doseff, A.I. (Poster, March 21-22, Awarded best poster). Characterization of PALs transcriptional regulatory network in maize. ASPB Midwestern Conference. St. Louis. MI.



2012 Tossey, J.*, Voss, O.H., and Doseff, A.I. Molecular Identification of Hsp27 Anti-Apoptotic Activity. (Poster Awarded 2nd place). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Tossey, J.*, Voss, O.H., and Doseff, A.I. Molecular fingerprinting of Hsp27-anti-apoptotic activity. (Poster-October 11, Awarded 2nd place undergraduate student category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Brahimaj, B.*, Arango, D., and Doseff, A.I. Molecular mechanisms of anti-carcinogenic flavonoids. (Poster-May11, Awarded Best Poster). Denman Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2011 Tossey, J.*, Voss, O.H., and Doseff, A.I. Molecular identification of Hsp27-anti-apoptotic activity. (Poster-April 29. Awarded Best Poster). Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University, Columbus, Ohio.



2008 Doolittle, J.M.*, Aguda, B., Doseff, A.I. Mathematical modeling of PKC-mediated activation of caspase-3 during cell death. (Awarded Best Poster). College of Biological Sciences Undergraduate Research Colloquium. The Ohio State University, Columbus, OH.



2004 Kolattukudy, S.J.*, The 3rd Annual Medical Center Graduate and Postgraduate Research Day. The Ohio State University, Columbus, OH.



2004 Kolattukudy, S.J.*, College Biological Sciences Undergraduate Research Colloquium Sp, 2004. The Ohio State University, Columbus, OH.



2002 Sancaktar, O.*, Wewers, M.D. and Doseff, A.I. The apoptotic machinery of monocytes is halted until caspase-3 is activated. (Poster, Awarded Complete expenses for assisting to a National or International Meeting). Landacre. The Ohio State University, Columbus, OH.

Noteworthy Graduate Narrative

PhD students graduated from my laboratory

Arango, D. (June 30) 2008-2015 PhD, OSU

Title thesis: The immune-modulatory and anti-carcinogenic mechanisms of the flavonoid apigenin



Malavez, Y. (Feb 28) 2006-2012 PhD, OSU

Title thesis: Mechanisms of caspase-3 regulation in the execution of cell death



Voss, O.H, MS 2004-2010 PhD, OSU

Title thesis: Regulation of apoptosis by caspase-3



Master students graduated from my laboratory

National

Nicholas, Courtney 2005-2009 Master Student, OSU

Title thesis: The anti-inflammatory mechanisms of the flavonoid apigenin in vitro and in vivo.



Vargo, M., MS 2003-2006 Master Student, OSU

Title thesis: The anti-carcinogenic and anti-inflammatory mechanisms of the flavonoid apigenin in mammalian cells.



International

Voss, O.H, MS 2002-2003 Master Student, University of Applied Sciences, Berlin Germany

Title thesis: Regulatory mechanisms of caspase-3 in apoptosis



Pineda, Catalina 2013 Master Student, National University of Colombia, Medellin. Colombia

Title thesis: Effects of the flavonoid apigenin in adipocyte differentiation and immune-response.



Student training

Graduate students research rotations


15 since 2008



Awards received by my Trainees for Best Poster Presentations

Graduate Students (* indicates the graduate student awardee; 13 since the last promotion)




2013 Arango, D.*, Morohashi, K., Yilmaz, A., Brahimaj, B., Kuramochi, K., Parihar, A.,Grotewold, E. and Doseff, A.I. (Poster-April 11- Awarded 1nd place graduate student category). The 12th Annual Ohio State University Medical Center and Graduate and Postgraduate Trainee Research Day. The Ohio State University, Columbus, Ohio.



2012 Duarte San Miguel, S.*, Pineda, C., Arango, D., and Doseff, A.I. Effect of apigenin on metabolic dysfunction in adipose tissue. (Poster-May 31. Awarded best poster) The 9th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, Ohio.



2011 Arango, D.*, Morohashi, K.,Yilmaz, A., Guttridge, D.C., Hei, W., Kuramochi, K., Grotewold, E., and Doseff, A.I. Innovative approach towards understanding the anti-inflammatory mechanisms of the flavonoid apigenin. (Poster-October 11, Awarded 2nd place graduate student category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2011 Hostetler, G.*, Riedl, K., Cardenas, H., Diosa-Toro, M., Schwartz, S., and Doseff, A.I. Deglycosilation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice. (Poster-April 9-14; Selected oral presentation). Experimental Biology, Washington, DC.



2010 Malavez, Y.*, and Doseff, A.I. Role of PKCδ dependent phosphorylation of caspase-3 on programmed cell death. (Selected Plenary talk, 1st place award). The Interdisciplinary Graduate Programs Symposium in the Molecular Life Sciences (MCDB, OSBP, and Biophysics). The Ohio State University, Columbus, OH. .



2010 Arango, D.*, Morohashi, K., Wang, L., Heine, G., Freitas, M. A., Grotewold, E. and Doseff, A.I. Anti-carcinogenic mechanisms of the plant flavonoid apigenin. (Poster, 1st place). The 7th Annual Russell Klein Nutrition Research Symposium. The Ohio State University, Columbus, OH.



2010 Voss, O.H.*, Parihar, A., Huang, Q., Wood, K., and Doseff, A.I. Determination of cellular life span from cells of the innate and adaptive immune system by the heat shock protein 27. (Poster, 1st place Graduate student category). The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day. The Ohio State University, Columbus, OH.



2009 Voss, O.H. and Doseff, A.I. Regulation of caspase-3 by heat shock proteins. (Oral presentation, 3rd place). 35th Edward F. Hayes Graduate Research Forum. The Ohio State University, Columbus, OH.



2009 Voss, O.H, Parihar, A, Huang, Q., Porcu, P., Wood, K., and Doseff, A.I. Regulation of CD8+CD57+ lymphocytes cell fate by heat shock proteins. (Poster, 1st place Graduate student category). 8th Annual OSU-Medical Center Research Day, Columbus, Ohio.



2009 Voss, O.H. and Doseff, A.I. Regulation of caspase-3 by heat shock proteins. (Oral presentation, 3rd place graduate student category). Scott Falkenthal Memorial Graduate Student Colloquium. The Ohio State University, Columbus, OH.



2008 Voss, O., Parihar, A., Huang, Q., Wood, K.L., and Doseff, A.I. Apoptosis is regulated by the interaction of caspase-3 with PKC and Hsp27. (Poster, 1st place). 3rd Annual Research day-Div. Pulmonary, Allergy Critical Care and Sleep Medicine. The Ohio State University, Columbus, OH.



2008 Voss, O.H., Malavez, Y., Gonzalez-Mejia, M.E., Batra, S., and Doseff, A.I. Falkenthal Memorial Graduate Student Colloquium. Regulation of cell fate by PKC-dependent phosphorylation of caspase-3 and its association with hsp27. (Best oral presentation). The Ohio State University, Columbus, OH.



2008 Voss, O.H., Malavez, Y., Gonzalez-Mejia, M.E., Batra, S., and Doseff, A.I. Regulation of cell fate by caspase-3, PKC, and Hsp27. (Best graduate student poster). The 7th Annual OSU-Medical Center Research Day. The Ohio State University, Columbus, OH.



2007 Nicholas, C., Batra, S., Vargo, M.A., Voss, O.H., Gavrilin, M.A., Guttridge,D., Grotewold, E., Wewers, M.D. and Doseff, A.I. The flavonoid apigenin suppresses acute lung injury. (Poster presentation selected for Oral, 2nd place best oral presentations). 1th Molecular Life Sciences Interdisciplinary Graduate Programs Symposium. The Ohio State University, Columbus, OH.



2007 Sharma, A., Vargo, M.A., Voss, O.H., Batra, S., and Doseff, A.I. (Apigenin-induced apoptotic release of histones H2B and H4 to the cytoplasm. (Poster). 2nd place in poster presentations). The 2nd Annual Davis Heart and Lung Research Institute Research Retreat. The Ohio State University, Columbus, Ohio.



2006 Voss, O. H. and Doseff, A.I. Caspase-3 phosphorylation by PKC has a proapoptotic effect. (Poster, best graduate student poster). The 5th Annual Medical Center Graduate and Postgraduate Research Day. The Ohio State University, Columbus, OH.



2006 Voss, O.H., Sharma, A. and Doseff, A.I. Biennial Retreat Molecular Biology and Cancer Genetics Program. Atwood Lake Resort, OH. (Best poster selected for podium presentation).



Awards Received by my Trainees

Graduate Students




Colciencias (NSF equivalent from Colombia) pre-doctoral fellowship 1/01/15-12/31/18

Duarte, S. (Predoctoral student) Doseff (Mentor)

Title: Immune-regulatory mechanisms of dietary flavonoids

Total award: $150,000



Keystone Symposia Future of Science Fund Scholarship. 1/01/14

Keystone Symposia. Silverthorne, CO. Competitive fellowship covered the trip to attend the Keystone Meeting.

Arango, D. (Predoctoral student) Doseff (Mentor)



Pelotonia Pre-doctoral Research Fellowship 7/01/13-6/30/15

Arango, D. (Predoctoral student) Doseff (Mentor)

Title: Molecular mechanisms of dietary flavonoids in breast cancer: novel role of nutraceuticals in

regulating alternative splicing

Total award: $53,000



Food and Innovation Center Research Student Grant 1/31/13-12/31/13

Arango, D. (Predoctoral student) Doseff (Mentor)

Title: Chemopreventive mechanisms of newly formulated apigenin-rich diets in breast cancer

Total Award: $5000



Travel Award Best Poster presentation 12th Trainee Research Day College of Medicine 04/13

Arango, D. (Predoctoral student) Doseff (Mentor)

Total Award: $1,000



Food and Innovation Center Travel Award to attend the Experimental Biology Meeting 04/13

Arango, D. (Predoctoral student) Doseff, A.I. (Mentor)

Total Award: $500



EnlazaMundos, Master Student Fellowship from Univ. Colombia, Medellin 04/01/11-03/31/12

Pineda, C. (student) Doseff, A.I. (mentor)

Title: Regulation of flavones in adipogenesis

Total award: $15,000



PHPID-Predoctoral Fellowship (Public Health Preparedness for infectious diseases) 1/31/11-12/31/11

Arango, D., (Predoctoral student) Doseff, A.I. (Mentor)

Title: Regulation of the TLR-mediated innate immune response by the flavonoid apigenin.

Total Award: $35,000



American Heart Association Predoctoral Fellowship 07/01/06-06/31/09

Voss, O. (Predoctoral student) Doseff, A.I. (Mentor)

Title: Regulation of human monocyte apoptosis by caspase-3 and small heat shock proteins.

Total Award: $42,000 Graduate School approved and waived the full cost of tuition

Postdoctoral / Researcher Advising

Currently in lab

Wei Li 2012–2015 Postdoctoral Researcher



Marcelo Pereira 2014–present Postdoctoral Researcher



Post-Doctoral Fellows Awards

Science without borders, Post-doctoral Research Fellowship from Brazil 11/01/14-10/30/16


Pereira, M. (Postdoc) Doseff, A.I. (Mentor).

Title: Regulatory networks responsible for the health beneficial effects of apigenin.

Total award: $ 50,000

Travel Award Best Poster presentation 12th Trainee Research Day College of Medicine 4/01/13

Voss, O. (Postdoc) Doseff, A.I. (Mentor).

Total Award: $1,000



Pelotonia Post-doctoral Research Fellowship 10/01/12-9/30/14

Kovinich, N. (Postdoc) E. Grotewold (Mentor) Doseff, A.I. (co-Mentor)

Title: New Frontiers in the Chemical Arsenal Against Cancer: Combining Modules of Semi-Synthesis and Synthetic Biology

Total Award: $98,600



NCI-Ruth L. Kirschstein 04/30/09-8/31/10

Heine, G., (Postdoc) Doseff, A.I. (Mentor)

Title: The role of BRCA1 in response to DNA damage

Total Award: $45,000



NIH-T32

Porchia, L., (Postdoc) Doseff, A.I. (Mentor) 01/01/08-01/31/09

Title: Regulation of monocyte fate by caspase 3, Heat Shock Protein 27 and Protein Kinase Cδ

Total Award: $44,000



Awards Received by my Trainees for Best Poster Presentations



Post-Doctoral Fellows (* indicates the postdoc awardee; 8 since the last promotion)

2014 Yang, F., Li, W., Doseff, A.I., and Grotewold, E. (Awarded 2nd Best Poster). The 8th Tripartite Workshop, Rutgers University, University of São Paulo, Brazil, and The Ohio State University. For sustainable technology innovations: integrating biology and chemistry for energy, food security and medicine. Rutgers, New Jersey. (Poster-Nov. 14-17).



2013 Voss, O.H.*, Tossey, J., and Doseff, A.I. Anti-apoptotic proteins: essential regulators of monocyte to macrophage life span and differentiation. (Poster-April 11- Awarded 1nd place post-doc category). The 12th Annual Ohio State University Medical Center and Graduate and Postgraduate Trainee Research Day. The Ohio State University, Columbus, Ohio.



2011 Voss, O.H.*, Tossey, J., and Doseff, A.I. Role of Hsp27 in monocyte to macrophage life span and differentiation. (Poster-October 11, Awarded 1st place postdoc category). Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Voss, O.*, Parihar, A., Huang, Q., Wood, K., and Doseff, A.I. Hsp27 determines cell fate of cell cells from the innate and adaptive immune system by regulating the activation of caspase-3. (Poster- 1st place postdoc category). The 5th Annual Pulmonary, Allergy, Critical Care and Sleep Research Day. The Ohio State University, Columbus, OH.



2010 Cardenas, H.*, Nicholas, C., Nishijima, Y., Nuovo, J., and Doseff A.I. The anti-inflammatory flavonoid apigenin reduces mortality in a mouse model of acute inflammation by inhibiting lung neutrophil infiltration and reducing MIP-2 chemokine expression. (Poster, awarded 1st place staff category). The 10th anniversary Davis Heart and Lung Research Institute Research Day. The Ohio State University, Columbus, Ohio.



2010 Voss, O.*, and Doseff, A.I. Monocytes and macrophages life span is regulated by the association of caspase-3 with Hsp27. 2010. (Poster, 1st place postdoc category). The 10th Annual Dorothy M. Davis Heart & Lung Research Institute Research Day. The Ohio State University, Columbus, OH.



2009 González-Mejia M.E.*, Murnan E.J., Voss O.H.+, and Doseff A.I. Apigenin-induced a bimodel phosphorylation of heat shock protein 27 via p38-MAPK and PKC regulates mitochondrial depolarization during apoptosis. (Poster). Cell Death Meeting. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. Travel Award.



2009 Gonzalez-Mejia, M.E.*, Murnan, E., Voss, O.H., and Doseff, A.I. Regulation of apoptosis by the association of caspase-3 with hsp27: role of Hsp27 phosphorylation. (Poster, 2nd Place Post-doc category). 11th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH.



2007 Batra, S., Nicholas, C., Vargo, M.A., Voss, O.H., Gavrilin, M.A., Guttridge,D., Grotewold, E., Wewers, M.D. and Doseff, A.I. The flavonoid apigenin regulates the production of inflammatory cytokines by promoting the dephosphorylation and inactivation of NF-B in LPS stimulated monocytes. (Poster selcted for Podium presentation, 3rd place best oral presentation). ). The 2nd Annual Davis Heart and Lung Research Institute Research Retreat. The Ohio State University, Columbus, OH.

Master/Graduate Advising

Mentoring - Current in my laboratory

Silvia Duarte January 2014-present Graduate Student



Jasmin, Valentin January 2014-present SiGuE post-baccalaureate fellow



Johanna Lin Winter 2012-present Honor Student



Qinhui Shao Winter 2013-present Honor Student



Luis Prada Salcedo March 2014-present Visiting Scholar



Roberto Alers July 2014-present SiGuE post-baccalaureate fellow



Edgar Lopez July 2014-present SiGuE post-baccalaureate fellow



Daniel Mantilla June 2015–present SiGuE post-baccalaureate fellow

Academic Advising

2003 - present Oliver H. The Ohio State University. Graduated 2003. Regulatory mechanisms of caspase-3 in apoptosis
2006 - present Eric Murnan The Ohio State University.
2006 - present Elaine Michelle The Ohio State University. Regulation of caspase-3 by Hsp27
2008 - present S.J. Kolattukudy The Ohio State University. Graduated 2006. The Role of Hsp27 in Human Monocyte Apoptosis
2008 - present M. Vargo The Ohio State University. Graduated 2006. The anti-carcinogenic and anti-inflammatory mechanisms of the flavonoid apigenin in mammalian cells
2008 - present M.E. Gonzalez-Mejia The Ohio State University. Graduated 2006.
2008 - present S. The Ohio State University. Graduated 2003.
2005 - 2007 A Sharma The Ohio State University.
2006 - 2008 Jeanette Doolittle The Ohio State University. Graduated 2008. Mechanisms of the regulation of apoptosis
2005 - 2009 Courtney Nicholas The Ohio State University. The anti-inflammatory mechanisms of the flavonoid apigenin in vitro and in vivo
2007 - 2010 Hassan Kamran The Ohio State University. Graduated 2010. Molecular mechanisms of caspase-3 dependent apoptosis
2010 Jennifer Yager-Schweller The Ohio State University.
2010 Jennifer Hernandez The Ohio State University.
2010 Margaret Apiagyei The Ohio State University.
2010 Hector Cordero The Ohio State University.
2011 Greg Hostetler The Ohio State University.
 

Chapters in Books

Doseff, A.I. and Parihar, A.. "Monocyte subsets and their role in tumor progression." In :Tumor Microenvironment and Myelomonocytic Cells. Edited by Dr. Subhra Biswas. -. ISBN: 978-953-51-0439-1: InTech, 43-62,, January 2012.

Parihar, A., Grotewold, E., and Doseff, A.I.. "Flavonoids Dietetics: Mechanisms and Emerging Roles of Plant Nutraceuticals." In :Pigments in Fruits and Vegetables: Genomics and Dietetics. Edited by Dr. Chunxian Chen. -.

 

Conferences

Doseff,A,I; Fahy,R,J; WEWERS,M,D. "Spontaneous monocyte apoptosis and endotoxin protection are dependent on caspase-3 and do not require caspase-1 activity." In FASEB JOURNAL. (March 1999). A519-A519.

Coulter,K,R; Doseff,A; Knoell,D,L. "Lung epithelial cells constitutively express caspase activity which is augmented by IL-1 and IFN-gamma." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (March 1999). A907-A907.

Marsh,C,B; Graham,M,M; Doseff,A,I; Kelley,T,W. "M-CSF stimulates cell survival through an Akt dependent pathway: effects on caspase activation.." In JOURNAL OF INVESTIGATIVE MEDICINE. (August 1999). 258A-258A.

Parker-Barnes,J,M; Yee,J,F; Doseff,A,I; WEWERS,M,D. "Isolation and characterization of I kappa B zeta, a new member of the I kappa B family: Interactions with IL-1 beta." In FASEB JOURNAL. (March 2002). A1082-A1082.

Knoell,D,L; Sweeney,P; Wang,Y,J; Doseff,A; Chaudhuri,A; Marsh,C,B. "FGF-7 prevents Fas-mediated apoptosis in A549 human lung epithelial cells via activation of Akt kinase." In FASEB JOURNAL. (March 2002). A677-A677.

Hostetler,Gregory,L; Riedl,Kenneth,M; Cardenas,Horacio; Toro,Mayra,Diosa; Schwartz,Steven,J; Doseff,Andrea,I. "Deglycosylation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." In FASEB JOURNAL. (April 2011). .

Arango,Daniel; Morohashi,Kengo; Yilmaz,Alper; Brahimaj,Bledi; Kuramochi,Kouji; Grotewold,Erich; Doseff,Andrea,I. "Identification of Human-Flavonoid Targets Using an Innovative Approach Reveals New Mechanisms Involved in Their Anti-Inflammatory Activities." In FASEB JOURNAL. (April 2012). .

Tossey,Justin; Voss,Oliver; Doseff,Andrea. "Molecular Fingerprinting of Hsp27 Anti-Apoptotic Activity." In FASEB JOURNAL. (April 2012). .

 

Degrees

1989 B.S., University of Buenos Aires

1989 None Indicated, Center for Plant Ecophysiology Buenos Aires Argentina

1996 Ph.D., State University of New York at Stony Brook

 

Editorial Activities

1997 - present Apoptosis
1999 - present Journal of Immunology
2003 - present Blood
2005 - present Journal of Biological Chemistry
2006 - present American Journal of Respiratory and Critical Care Medicine
2006 - present Cell Death and Differentiation
2006 - present Stem Cell and Development
2006 - present American Journal of Physiology
2006 - present Biochemical Pharmacology
2007 - present PlosOne
2008 - present Journal of Leukocyte Biology
2008 - present Journal of Lipid Research
2009 - present Cell Death and Disease
2010 - present Investigational New Drugs
2010 - present Frontier in Biosciences
2010 - present BBA-MCR (Molecular Cell Research)
2010 Frontier in Biosciences, Special Issue: Mechanisms of survival and cell death in leukocytes
2011 - present PlosOne Genetics
2011 - present Cell Biology and Toxicology
2012 - present Molecular Nutrition and Food Research
2012 - present Mutational Research
2012 - present Experimental Cell Research
2012 - present Current Nutrition and Food Science
2012 - present PlosOne Pathogens
2013 - present Phytotheraphy Research
2013 - present Journal Medicinal Food
2014 - present Nature Communications
2014 - present Pharmacology & Therapeutics
2014 - present Journal of Medicinally Active Plants (JMAP)
2015 - present Cell Biochemistry and Biophysics
 

Honors

1988 - 1989 PhD Graduate Fellowship. Argentine National Research Council (CONICET), Argentina.
1996 - 1998 Postdoctoral Fellowship. National Institutes of Health.
1999 - 2001 Research Grant. American Lung Association.
2007 - present Nominated: OSU Distinguished Undergraduate Research Mentor of the Year. Ohio State University Undergraduate Program.
2010 1st Place, Poster Award. The Davis Heart and Lung Research Institute.
2013 - present Sphinx Mortar 24th Annual Faculty and Staff Recognition (nominated by an OSU undergraduate). Sphinx and Mortar Board Society.
2013 - present Nominated: OSU Distinguished Undergraduate Research Mentor of the Year. Ohio State University Undergraduate Program.
 

Journal Articles

Barneix,A,J; Doseff,A,I; RODGERS,C,O. "NITRATE REDUCTASE-ACTIVITY IN ARGENTINE WHEAT CULTIVARS." CEREAL RESEARCH COMMUNICATIONS. Vol. 16, no. 3-4. (January 1988.): 269-272.

Barneix A.J; Doseff A.I.; Rodgers C.O.. "Nitrate reductase activity In Argentine wheat cultivars." Cereal Research Communications. Vol. 16, no. 3-4. (January 1989.): 269-272.

Doseff,A; Martienssen,R; Sundaresan,V. "SOMATIC EXCISION OF THE MU1 TRANSPOSABLE ELEMENT OF MAIZE." NUCLEIC ACIDS RESEARCH. Vol. 19, no. 3. (February 1991.): 579-584.

Doseff, A.I.; Martienssen, R; Sundaresan, V. "Somatic excision of the Mu1 transposable element of maize.." Nucleic Acids Research. Vol. 19, no. 3. (February 1991.): 579-584.

Doseff, A.I.; Arndt, K.T.. "Las1 is an essential nuclear protein involved in morphogenesis and cell surface growth.." Genetics. Vol. 141, no. 3. (November 1995.): 857-871.

Doseff,A,I; Arndt,K,T. "LAS1 IS AN ESSENTIAL NUCLEAR-PROTEIN INVOLVED IN CELL MORPHOGENESIS AND CELL-SURFACE GROWTH." GENETICS. Vol. 141, no. 3. (November 1995.): 857-871.

Nestler, H.P; Doseff, A. I.. "A two-dimensional, diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis technique to screen for proteases substrates in protein mixtures.." Analytical Biochemistry. Vol. 251, no. 1. (August 1997.): 122-124.

Nestler,H,P; Doseff,A. "A two-dimensional, diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis technique to screen for protease substrates in protein mixtures." ANALYTICAL BIOCHEMISTRY. Vol. 251, no. 1. (August 1997.): 122-125.

Kelley, T.W; Graham, M.M; Doseff, A. I.; Pommerantz, R.W; Lau, S.M; Ostrowski, M.C; Franke, T.M., Marsh, C.B;. "Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B.." The Journal of Biological Chemistry. Vol. 274, no. 37. (September 1999.): 26393-26398.

Fahy,R,J; Doseff,A,I; WEWERS,M,D. "Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1." JOURNAL OF IMMUNOLOGY. Vol. 163, no. 4. (August 1999.): 1755-1762.

Kelley,T,W; Graham,M,M; Doseff,A,I; Pomerantz,R,W; Lau,S,M; Ostrowski,M,C; Franke,T,F; Marsh,C,B. "Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 274, no. 37. (September 1999.): 26393-26398.

Kirsch, D.G; Doseff, A.I.; Chau, B.N; Lim, D., Souza-Pinto, N.C; Hansford, R; Kastan, M.B; Lazebnik, Y. A; Hardwick, J M. "Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c.." The Journal of Biological Chemistry. Vol. 274, no. 30. (January 1999.): 21155-21161.

Fahy, R. J; Doseff, A. I.; Wewers, M D. "Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway which is blocked by endotoxin and is independent of caspase-1.." Journal of Immunology. Vol. 163, no. 4. (August 1999.): 1755-1762.

Coulter, K.R., Doseff, A.I., Sweeney, P., Wang, Y., Marsh, C.B.; Wewers, M.D; Knoell, D.L.. "Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells.." American Journal of Respiratory Cell and Molecular Biology. Vol. 26, no. 1. (January 2002.): 58-66.

Rovin,B,H; Wilmer,W,A; Lu,L; Doseff,A,I; Dixon,C; Kotur,M; Hilbelink,T. "15-Deoxy-Delta(12,14)-prostaglandin J(2) regulates mesangial cell proliferation and death." KIDNEY INTERNATIONAL. Vol. 61, no. 4. (April 2002.): 1293-1302.

Rovin, B.H; Wilmer, W.A; Lu, L., Doseff, A.I.; Dixon, C., Kotur, M., Hilbelink, T.. "The cyclopentenone prostaglandin 15-Deoxy-Δ12,14-prostaglandin J2 regulates mesangial cell proliferation and death.." Kidney International. Vol. 61, no. 4. (January 2002.): 1293-1302.

Goyal,A; Wang,Y,J; Graham,M,M; Doseff,A,I; Bhatt,N,Y; Marsh,C,B. "Monocyte survival factors induce Akt activation and suppress caspase-3." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 26, no. 2. (February 2002.): 224-230.

Doseff,A,I; Baker,J,H; Bourgeois,T,A; WEWERS,M,D. "Interleukin-4-induced apoptosis entails caspase activation and suppression of extracellular signal-regulated kinase phosphorylation." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 29, no. 3. (September 2003.): 367-374.

Doseff, A.I., Baker Jr., J.H., Bourgeois, T.A. and Wewers, M.D.. "IL-4-induced apoptosis entails caspase activation and dephosphorylation of ERK." Am. J. Resp. Cell and Mol. Biology. Vol. 269, (September 2003.): 367-374.

Zeigler,M,M; Doseff,A,I; Galloway,M,F; Opalek,J,M; Nowicki,P,T; Zweier,J,L; Sen,C,K; Marsh,C,B. "Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 278, no. 15. (April 2003.): 12894-12902.

Zeigler, M.M; Doseff, A.I.; Galloway, M.F; Opalek, J.M; Nowicki, P.T; Zweier, J.L; Sen, C.K; Marsh, C.B.. "The presentation of nitric oxide regulates monocyte life and death through effects on caspase-9 and caspase-3 activation.." The Journal of Biological Chemistry. Vol. 278, no. 15. (April 2003.): 12894-12900.

Elssner, A.; Doseff, A.I.; Duncan, M.; Kotur, M.; Wewers, M.D.. "Interleukin-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis.." Journal of Immunology. Vol. 172, no. 12. (January 2004.): 7721-7725.

Doseff, Andrea I.. "Apoptosis: the sculptor of development.." Stem cells and Development. Vol. 13, no. 5. (January 2004.): 473-483.

Wei, G; Guo, J, Doseff, AI, Kusewitt, DF, Man, AK, Oshima, RG; Ostrowski, MC. "Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.." Journal of Immunology. Vol. 173, no. 2. (January 2004.): 1374-1379.

Voss,O,H; Kim,S; WEWERS,M,D; Doseff,A,I. "Regulation of monocyte apoptosis by the protein kinase C delta-dependent phosphorylation of caspase-3." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 280, no. 17. (April 2005.): 17371-17379.

Bao, S; Wang, Y; Sweeney, P; Chaudhuri, A; Doseff, AI; Marsh, CB; Knoell, DL. "Keratynocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells.." American Journal of Physiology. Lung Cellular and Molecular Physiology. Vol. 288, no. 1. (January 2005.): L36-42.

Voss, OH; Kim, S; Wewers, MD; Doseff, AI. "Caspase 3 is a phosphoprotein and associates with PKCδ during spontaneous monocyte apoptosis." The Journal of Biological Chemistry. Vol. 280, no. 17. (January 2005.): 17371-17379.

Vargo, MA; Voss, OH; Poustka, F; Cardounel, AJ; Grotewold, E; Doseff, AI. "Apigenin-induced-apoptosis is mediated by the activation of PKCσ and caspases in leukemia cells." Biochemical Pharmacology. Vol. 72, no. 6. (January 2006.): 681-692.

Voss, Oliver, H; Batra, Sanjay; Kolattukudy, Sunny, J; Gonzalez-Mejia, M Elba; Smith, Jeffrey, B; and Doseff, AI. "Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation." The Journal of Biological Chemistry. Vol. 282, no. 34. (January 2007.): 25088-25099.

Nicholas, C; Batra, S; Vargo, MA; Voss, OH; Gavrilin, MA; Wewers, MD; Guttridge, DC; Grotewold, E; Doseff, AI. "Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NFκB through the suppression of p65 phosphorylation." Journal of immunology. Vol. 179, (January 2007.): 7121-7127.

Voss, O.H., Batra, S., Kolattukudy, S.J., Gonzalez-Mejia, M.E., Smith, J.B. and Doseff, A.I. "Heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation." J. Biol. Chem.. Vol. 282, (January 2007.): 25088-25099.

Malavez Y, Gonzalez-Mejia ME, Doseff, AI. "PKCδ." Atlas Genet Cytogenet Oncol Haematol. (January 2008.): -.

Gonzalez-Mejia ME, Doseff, AI. "Regulation of monocytes and macrophages cell fate." Frontiers in Bioscience. Vol. 14, (January 2009.): 2413-2431.

Wood KL, Twigg III, HL, Doseff, AI. "Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation." Frontiers in Biosciences. Vol. 14, (January 2009.): 3771-3781.

Pasupuleti,N; Matsuyama,S; Voss,O; Doseff,A,I; Song,K; DANIELPOUR,D; Nagaraj,R,H. "The anti-apoptotic function of human alpha A-crystallin is directly related to its chaperone activity." CELL DEATH & DISEASE. Vol. 1, (March 2010.): e31-.

Parihar, A., Eubank, T. and Doseff, A.I.. "Monocytes and Macrophages Regulate Immunity through Dynamic Networks of Survival and Cell Death." J. Innate Immunity. Vol. 2, no. 3. (January 2010.): 204-215.

Wood, K.L., Nunley, D.R., Moffat-Bruce, S., Pope-Harman, A., Huang, Q., Shamo, E.N., Philips, G.S., Barna, C., Batra, S., Marsh, C.B., Doseff, A.I.. "The role of Heat Shock Protein 27 in Bronchiolitis Obliterans syndrome after lung transplantation." J. Heart and Lung Transplantation. Vol. 29, (January 2010.): 786-791.

Gonzalez-Mejia, M.E.*, Voss, O.H.*, Murnan, E.J., and Doseff, A.I.. "Apigenin-induced-apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of Heat Shock Protein 27." Cell Death Disease. Vol. 10, (August 2010.): 1038-.

Wood, K.L., Voss, O.H., Huang, Q., Parihar, A., Metha, N., Batra, S., and Doseff, A.I.. "The small heat shock protein 27 is a key regulator of CD8+ CD57+ lymphocyte survival." J. Immunol.. Vol. 184, (January 2010.): 5582-5588.

Pasupuleti, N., Matsuyama, S., Voss, O.H., Doseff, A.I., Song, K., Danielpour, D., Nagaraj, R.. "Anti-apoptotic functions of human A-crystallin: relation to the chaperone function." Cell Death and Disease. (January 2010.): -.

Parihar, A., Eubank, T., Doseff, A.I.. "Monocytes and Macrophages regulate immunity through dynamic networks of survival and cell death." J. Innate Immunity. Vol. 2, (January 2010.): 204-215.

Henkels,Karen,M; Frondorf,Kathleen; Gonzalez-Mejia,M,Elba; Doseff,Andrea,L; Gomez-Cambronero,Julian. "IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)." FEBS LETTERS. Vol. 585, no. 1. (January 2011.): 159-166.

Abdelaziz,Dalia,HA; Gavrilin,Mikhail,A; Akhter,Anwari; Caution,Kyle; Kotrange,Sheetal; Khweek,Arwa,Abu; Abdulrahman,Basant,A; Hassan,Zeinab,A; El-Sharkawi,Fathia,Z; Bedi,Simranjit,S; Ladner,Katherine; Gonzalez-Mejia,M,Elba; Doseff,Andrea,I; Mostafa,Mahmoud; Kanneganti,Thirumala-Devi; Guttridge,Dennis; Marsh,Clay,B; Wewers,Mark,D; Amer,Amal,O. "Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages.." Frontiers in microbiology. Vol. 2, (January 2011.): 3389-.

Abdelaziz, D.H.A.; Gavrilin, M.A.; A Kyle caution, Kotrange, S., Khweek, A.A.; Abdulrahman, B.A.; Hassan, Z.A.; El-Sharkawi, F.Z.; Bedi, S.S.; Ladner, K.; Gonzalez-Mejia, M.E.; Doseff, A.I.; Mostafa, M.; Kanneganti, T-D.; Guttridge, D.; Marsh, C.B.; Wewers, M.D. and Amer, A.O.. "Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages." Frontiers in Microbiology. (January 2011.): -.

Henkels, K.M., Frondorf, K., Gonzalez-Mejia, M.E., Doseff, A.I., and Cambronero, J.G.. "IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)." FEBS Letters. Vol. 585, (January 2011.): 159-166.

Hostetler,Gregory; Riedl,Ken; Cardenas,Horacio; Diosa-Toro,Mayra; Arango,Daniel; Schwartz,Steven; Doseff,Andrea,I. "Flavone deglycosylation increases their anti-inflammatory activity and absorption." MOLECULAR NUTRITION & FOOD RESEARCH. Vol. 56, no. 4. (April 2012.): 558-569.

Akhter,Anwari; Caution,Kyle; Abu Khweek,Arwa; Tazi,Mia; Abdulrahman,Basant,A; Abdelaziz,Dalia,HA; Voss,Oliver,H; Doseff,Andrea,I; Hassan,Hoda; Azad,Abul,K; Schlesinger,Larry,S; Wewers,Mark,D; Gavrilin,Mikhail,A; Amer,Amal,O. "Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization." IMMUNITY. Vol. 37, no. 1. (July 2012.): 35-47.

Das,Amlan; Gopalakrishnan,Bhavani; Voss,Oliver,H; Doseff,Andrea,I; Villamena,Frederick,A. "Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling." BIOCHEMICAL PHARMACOLOGY. Vol. 84, no. 4. (August 2012.): 486-497.

Arango, D., Parihar, A., Villamena, F.A., Wang, L., Freitas, M.A., Grotewold, E., and Doseff, A.I.. "Apigenin induces DNA damage through the PKCo dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repaor." Biochem. Pharmacol. Vol. 4, (January 2012.): 1571-1580.

Duarte, S.#, Arango, D.#, Yasmeen, R. Parihar, A., Hamel, P., and Doseff, A.I.. "Apigenin protects endothelial cells of LPS-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function." International Journal of Molecular Sciences. Vol. 14, (January 2013.): 17664-17679. #Indicates shared first authorship.

Naomi, R.B., Wang, B., Voss, O., Doseff, A.I., Santhoshkumar, P. and Nagaraj, R.H.. "Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization and opacification in experimental cataracts." J. Biol. Chem.. Vol. 288, (January 2013.): 13022-13035.

Lakshmanan, A., Doseff, A.I., Ringel, M.D., Saji, M., Roussel, B., Zhang, X. and Jhiang, S.M.. "Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated readioiodide accumulation in thyroid cells." Thyroid. Vol. 24, (October 2014.): 878-887..

Casas, M.I., Duarte, S.M., Doseff, A.I.*, and Grotewold, E*.. "Flavone-rich maize: an opportunity to improve the nutritional value of an important commodity crop." Frontiers in Plant Sciences. Vol. 5, (September 2014.): 1-11. *Shared corresponding author..

Malavez, Y.#, Voss, O.#, Parihar, A., Gonzalez-Mejia, M.E. and Doseff, A.I.. "Distinct contribution of protein kinase C delta and protein kinase C epsilon in the lifespan and immune response of human blood monocyte subpopulations." Immunology. Vol. 144, no. 4. (April 2015.): 611-620. # Indicates shared first authorship..

Arango, D., Diosa-Toro, M., Rojas-Hernandez, L.S., Cooperstone, J.L., Schwartz, S., Mo, X., Jiang, J., Schmittgen, T., Doseff, A.I. "Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation." Mol. Nutrit. Food Res.. Vol. 59, (January 2015.): 763-772.

Arango, D.#, Morahashi, K.#, Yilmaz, A., Kuramichi, K., Parihar, A., Brahimaj, B., Grotewold, E., and Doseff, A.I.. "Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets." Proc. Natl. Acad. Sci. USA. -.

Gray, J., Burdo, B., Goetting-Minesky, M. P., Wittler, B., Hunt, M., Li, T., Velliquette, D., Thomas, J., Key, K., Gentzel, I., dos Santos Brito, M., Mejía-Guerra, M.K., Connolly, L. N., Qaisi, D., Li, W., Casas, M. I., Doseff, A.I., and Grotewold, E.. "Protocol for the Generation of a Transcription Factor Open Reading Frame Collection (TFome).." BioProtocols. -.

Parihar, A., Duarte S. and Doseff, A.I.. "The saga of food supplements: safety and missing knowledge." J. Med. Active Plants. -.

 

Inventions and Patents

Doseff, A.I.; Grotewold, E. "Dietary flavones increase efficacy of chemotherapeutic drugs." Filed August 2013.

Doseff, A.I.; Erich Grotewold. "Inhibition of monocyte survival, differentiation or proliferation." Filed January 2005.

Doseff, A.I.: Swartz, Stephen; Hostetler, Gregory; Riedl, Ken; Cardenas, Horacio. "Processes for improving absorption and anti-inflammatory activity of dietary flavones." Filed January 2011.

Doseff, A.I.; Wood, K.. "The small Heat shock protein 27 (Hsp27) is a marker for cellular life span." Filed September 2006.

 

Presentations

"Genetic screen to isolate genes involved in the function of SIT-4 phosphatiase." Presented at Meeting on Cell Cycle, Cold Spring, NY, US|USA. (January 1995)

"Delineating the caspase cascade by caspase depletion." Presented at Meeting on Programmed Cell Death, Cold Spring, NY, US|USA. (January 1997)

"Lung epithelial cells constitutively express caspase activity which is augmented by IL-1 and INF-gamma." Presented at American Thoracic Society International Conference, San Diego, CA, US|USA. (January 1999)

"Caspase activity in monocyte apoptosis." Presented at American Thoracic Society International Conference, Toronto, CA|CAN. (January 2000)

"The cyclopentenone prostaglandin 15-deoxy-delta^12,14-PGJ2{15dPGJ2} regulates human mesangial cell (HMC) proliferation and survival." Presented at ASN/ISN World Congress of Nephrology, San Francisco, CA, US|USA. (January 2000)

"Caspase-3 phosphorylation and its role in monocyte apoptosis." Presented at American Thoracic Society International Conference, Toronto, CA|CAN. (January 2000)

"Spontaneous monocyte apoptosis and endotoxin protection are dependent on caspase-3 and do not require caspase-1 activity." Presented at FASEB, Washington, DC, US|USA. (January 2000)

"Caspases: regulating by proteolysis the apoptotic cascade." Presented at American Thoracic Society International Conference, Toronto, CA|CAN. (January 2000)

"Dissecting the killing caspase cascade in human monocytes." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2000)

"Nitric oxide has a dual role in monocyte apoptosis via caspase-3 and the AKT-dependent pathway." Presented at FASEB, Orlando, FL, US|USA. (January 2001)

"Nitric oxide has a dual role in monocyte apoptosis via caspase-3." Presented at Research Conference, Pathology Department, Columbus, OH, US|USA. (January 2001)

"Monocyte survival induced by inflammatory cytokines and growth factors results from supression of caspase-3 activity in a PI 3-kinase dependent manner." Presented at American Thoracic Society International Conference, San Francisco, CA, US|USA. (January 2001)

"IL-4 induces apoptosis of activated monocytes through a caspase-dependent pathway." Presented at American Thoracic Society International Conference, San Francisco, CA, US|USA. (January 2001)

"Title Not Specified." Presented at Internal Medicine Fellows Day, Columbus, OH. (January 2001)

"Caspase-3 is a phosphoprotein and associates with a kinase that is modulated during monocyte activation and spontaneous monocyte apoptosis." Presented at Keystone Symposia, Keystone, CO, US|USA. (January 2001)

"Title Not Specified." Presented at Molecular Biology and Cancer Genetics Program Conference, Columbus, OH, US|USA. (January 2001)

"Caspase-3 is a phsphoprotein that associates with and is phosphorylated selectively by a PKC isoform during monocyte lifespan." Presented at American Thoracic Society International Conference, . (January 2002)

"Killer caspases: The good guys in cancer and inflammation." Presented at Seminar Series, Columbus, OH, US|USA. (January 2002)

"Killer caspases: The executioners of apoptosis in cancer and inflammation." Presented at Winthrop-University Hospital, Mineola, NY, US|USA. (January 2002)

"A bioinformatic approach to identifying new human apoptotic markers." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2002)

"MAIL gene is rapidly induced by LPS in monocytes but not in alveolar macrophages." Presented at American Thoracic Society International Conference, Atlanta, GA, US|USA. (January 2002)

"Cardiak is constitutively expressed in monocytes and interacts transiently with caspase-1 after endotoxin." Presented at Keystone Symposia, Keystone, CO, US|USA. (January 2002)

"Cardiak is a constitutively expressed in monocytes and interacts transiently with caspase-1 after endotoxon." Presented at FASEB, New Orleans, LA, US|USA. (January 2002)

"The apoptic machinery of monocytes is halted until caspase-3 is activated." Presented at Landacre, Columbus, OH, US|USA. (January 2002)

"An immunomagnetic based technology to quantify receptors presence and numbers on alveolar macrophages." Presented at American Thoracic Society International Conference, Seattle, WA, US|USA. (January 2003)

"Caspase-3 is a phosphoprotein that associates with and is phosphorylated selectively by a PKC during monocyte lifespan." Presented at American Thoracic Society International Conference, Seattle, WA, US|USA. (January 2003)

"IL-4 induces apoptosis of activated monocytes by inducing ERK dephosphorylation and reactivation of caspases." Presented at American Thoracic Society International Conference, . (January 2003)

"When cells dye: pathways and approaches to study apoptosis." Presented at Sunrise Seminar, American Thoracic Society International Conference, . (January 2003)

"Molecular mechanisms of apoptosis." Presented at Molecular and Cell Developmental Biology Program, The Ohio State University, . (January 2003)

"Mechanisms of apoptosis in cancer and innate immunity." Presented at University of Buenos Aires, . (January 2003)

"Killer caspases: executing cell death by proteolysis." Presented at University of Buenos Aires, . (January 2003)

"Caspases: Regulating monocyte lifespan during innate immunity." Presented at The Heart and Lung Research Institute, The Ohio State University, . (January 2003)

"Apoptotic proteases as executioners of unwanted cells." Presented at Human Cancer Genetics, The Ohio State University, . (January 2003)

"Mitochondria depolarization is hastened by caspase-3 inhibitor during spontaneous monocyte apoptosis and is not required during Fas-induced monocyte apoptosis." Presented at American Thoracic Society International Conference, Seattle, WA, US|USA. (January 2003)

"The role of caspase-3 regulation in cell death of breast cancer cells." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2003)

"Identification of substrates of caspases in breast cancer cells by proteomics." Presented at Congreso Colombiano de Bioingenieria e Ingenieria Biomedica, Bogota. (January 2003)

"Role of Hsp27 in the regulation of monocytes apoptosis." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2004)

"Hsp27 regulation in monocytes." Presented at Medical Center Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2004)

"Hsp27 regulates caspase-3 in monocytes." Presented at Undergraduate Colloquium, Columbus, OH, US|USA. (January 2004)

"The role of HSP in monocyte apoptosis." Presented at Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2004)

"Caspase-3 phosphorylation by PKC-8 has a proapoptotic effect by increasing its activity and inhibition of PKC-8 induces prolonged human monocyte survival." Presented at American Thoracic Society International Conference, Orlando, FL, US|USA. (January 2004)

"Small heat shock proteins are differentially regulated and their localization varies during human monocyte apoptosis and prolonged survival." Presented at American Thoracic Society International Conference, Orlando, FL, US|USA. (January 2004)

"Regulation of monocyte life span y the interaction of hsp27 with caspase-3." Presented at Biennial Retreat Molecular Biology and Cancer Genetics Program, Atwood, OH, US|USA. (January 2005)

"Caspase-3 phosphorylation by PKC-8 has a proapoptotic effect." Presented at Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2005)

"Caspase-3 phosphorylation by PKC-8 has a proapoptotic effect." Presented at Medical Center Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2005)

"The flavonoid apigenin is a potent inducer of apoptosis in monocytic leukemias." Presented at Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2005)

"Flavonoids: anti-cancer and anti-inflammatory compounds." Presented at Therapeutic Team, Department of Internal Medicine, The Ohio State University, . (January 2005)

"Caspases controlling life and death in cancer and immunity." Presented at Department of Molecular Genetics, The Ohio State University, . (January 2005)

"Apoptosis." Presented at Basic Research Conference, Div. Pulmonary and Critical Care, The Ohio State University, . (January 2005)

"Regulation of caspase-3 via PKC-8 phosphorylation." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2006)

"Regulation of cell death by phosphorylation of caspase-3." Presented at The Ohio Student Research Forum, Columbus, OH, US|USA. (January 2006)

"Regulation of programmed cell death: implications for cancer and inflammation." Presented at Graduate Program in Oral Biology Seminar Series, The Ohio State University, . (January 2006)

"Executioners caspases controlling life and death in cancer and immunity." Presented at University of Buenos Aires, Buenos Aires, AR|ARG. (January 2006)

"Apoptosis: sculptor of development." Presented at Meeting for Gynecologic Investigation, Toronto, CA|CAN. (January 2006)

"Apigenin-induced apoptotic release of histones H2B and H4 to the cytoplasm." Presented at The 1st Annual Pulmonary Critical Care, Allergy and Sleep Research Day, Columbus, OH, US|USA. (January 2006)

"Monocyte Life Span by the Interaction of Hsp27 and PKC 8 with Caspase -3.." Presented at International Conference, San Diego, CA, US|USA. (January 2006)

"Regulation of apoptosis by caspase-3 mediated by Hsp27 and PKC-8." Presented at The 8th Annual Comprehensive Cancer Center Scientific Meeting, Columbus, OH, US|USA. (January 2006)

"Interaction of Hsp27 and PKC-8 with caspase-3 regulates monocyte life span." Presented at The 5th Annual Comprehensive Cancer Center Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2006)

"Interaction of Hsp27 and PKC-8 with caspase-3 regulates monocyte life span." Presented at 5th Anniversary Celebrations of the Heart and Lung Research Institute, Columbus, OH, US|USA. (January 2006)

"Heat Shock Protein 27 regulates monocyte life span by inhibiting caspase-3 activation." Presented at 1st Annual Pulmonary, Critical Care, Allergy and Sleep Research Day, Columbus, OH, US|USA. (January 2006)

"Monocyte Life Span by the Interaction of Hsp27 and PKC-8 with Caspase-3." Presented at American Thoarcic Society International Conference, San Diego, CA, US|USA. (January 2006)

"The role of HSP27 and PKC as regulators of caspase-3 during apoptosis." Presented at The 1st Annual Pulmonary, Critical Care, Allergy and Sleep, Research Day, Columbus, OH, US|USA. (January 2006)

"The flavonoid apigenin regulates the production of inflammatory cytokines by promoting the dephosphorylation and inactivation of NF-kB in LPS stimulated monocytes." Presented at The 1st Annual Pulmonary Critical Care, Allergy and Sleep Research Day, Columbus, OH, US|USA. (January 2006)

"Regulation of cell fate: the caspases attack." Oxford, OH, US|USA. (January 2007)

"Regulation of apoptosis: implications for cancer and innate immunity." Cleveland, OH, US|USA. (January 2007)

"PKC8 dependant phosphorylation of caspase-3 and its association with Hsp27 regulate monocyte life span." Presented at Cell Death Meeting, Cold Spring Harbor, NY, US|USA. (January 2007)

"Heat Shock Protein 27 regulates monocyte life span by inhibiting caspase-3 activation.." Presented at American Thoracic Society International Conference, San Francisco, CA, US|USA. (January 2007)

"The flavonoid apigenin suppresses acute lung injury. (Oral Presentation)." Presented at Interdisciplinary Graduate Programs Symposium, Columbus, OH, US|USA. (January 2007)

"Regulation of apoptosis by heat shock proteins and PKC." Cleveland, OH, US|USA. (January 2008)

"Anti-inflammatory and anti-carcinogenic mechanisms of plant natural products.." Presented at May-June-Pan-American Advance Studies Institute (PASI), PE|PER. (January 2008)

"The role of Heat shock protein 27 in Bronchiolitis obliterans after lung transplantation." Presented at American Thoracic Society International Conference, Ontario, CA|CAN. (January 2008)

"Caspase-3 phosphorylation is mediated by the association of PKC and Hsp27 during apoptosis." Presented at The 3rd Annual Davis Heart and Lung Research Institute Research Retreat, Columbus, OH, US|USA. (January 2009)

"Apigenin induces DNA damage in a PKC-dependent manner." Presented at The 3rd Annual Davis Heart and Lung Research Institute Research Retreat, Columbus, OH, US|USA. (January 2009)

"Determination of cellular life span through the intearction of caspase-3 with PKC and Hsp27." Presented at The 3rd Annual Davis Heart and Lung Research Institute Research Retreat, Columbus, OH, US|USA. (January 2009)

"Regulation of cell fate by PKCd-dependent phosphorylation of caspase-3 and its association with Hsp2." Presented at Falkenthal Memorial Graduate Student Colloquium, Columbus, OH, US|USA. (January 2009)

"The small heat shock protein 27 regulates monocyte/macrophage survival and differentiation." Presented at American Thoracic Society International Conference, San Diego, CA, US|USA. (January 2009)

"Natural immune-regulators: alternative therapeutic approaches in acute lung injury." Presented at The Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2009)

"Regulation of cell fate in leukocytes." Presented at National Academy of Medicine, Buenos Aires, AR|ARG. (August 2010)

"Determination of cellular life span from cells of the innate and adaptive immune system by the heat shock protein 27." Presented at The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day., Columbus, OH, US|USA. (January 2010)

"Hsp27 determines cell fate of cells from the innate and adaptive immune system by regulating the activation of caspase-3." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Monocytes and macrophages life span is regulated by the association of caspase-3 with Hsp27." Presented at The 10th Annual Dorothy M. Davis Heart and Lung Research Institute Day, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at The 10th Anniversary, Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory activity of foodsxtracts in vitro and absorption of dietary flavones from celery in a mouse model." Presented at The 7th Annual Russell Klein Nutrition Research Symposium, Columbus, OH, US|USA. (January 2010)

"Protective effect of apigenin against mortality induced by acute inflammation in mice is associated with reducition on MIP-2 chemokine expression and lung nutrophil infiltration." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"The anti-inflammatory flavonoid apigenin reduces mortality in a mouse model of acute inflammation by inhibiting lung neutrophil infiltration and reducing MIP-2 chemokine expression." Presented at The Davis Heart and Lung Research Day, Columbus, OH, US|USA. (January 2010)

"Apigenin reduces mortality in a mouse model of acute lung injury by inhibiting neutrophil infiltration, MIP-2, and apoptosis in the lungs." Presented at 12th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-3-PKC-dependent phosphorylation in apoptosis." Presented at Biological, Mathematical, and Physical Sciences Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-3-PKC-dependent phosphorylation in apoptosis." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Anti-proliferative mechanisms of the flavonoid apigenin." Presented at 12th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2010)

"Anti-carcinogenic mechanisms of the plant flavonoid apigenin." Presented at The 24th Annual Summer Research Opportunities Program Conference, Columbus, OH, US|USA. (January 2010)

"Anti-carcinogenic mechanisms of the plant flavonoid apigenin." Presented at The 7th Annual Russell Klein Nutrition Research Symposium, Columbus, OH, US|USA. (January 2010)

"Modulation of caspase-3 enzymatic activity by PKC phosphorylation during apoptosis." Presented at The 9th Annual Ohio State University Medical Center and Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (January 2010)

"PKCo phosphorylation of caspase-3 promotes apoptosis through a complex regulatory network." Presented at The 10th Anniversary, Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2010)

"Phosphorylation of caspase-3 regulates apoptosis through a complex regulatory network." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Role of PKCo dependent phosphorylation of caspase-3 on programmed cell death." Presented at The Interdisciplinary Graduate Programs Symposium in the Molecular Life Sciences (MCDB, OSBP, and Biophysics), Columbus, OH, US|USA. (January 2010)

"Phosphorylation of Hsp27 reduces its association with caspase-3 inducing monocyte apoptosis." Presented at The 5th Annual Research Day, Davis Heart and Lung Research Institute Research Say, Columbus, OH, US|USA. (January 2010)

"Apigenin-induced a bimodel phosphorylation of heat shock protein 27 via p38-MAPK and PKC regulates mitochondrial depolarization during apoptosis." Cold Spring Harbor, NY, US|USA. (January 2010)

"Target identification of the flavonoid apigenin: implications fortis anti-inflammatory activity." Presented at The 10th Anniversary, Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2010)

"Anti-inflammatory mechanism of the flavonoid apigenin." Presented at 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-dependent apoptosis." Presented at Denman Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Molecular mechanisms of caspase-dependent apoptosis." Presented at Biological, Mathematical, and Physical Sciences Undergraduate Research Forum, Columbus, OH, US|USA. (January 2010)

"Mapping the heat shock protein 27 peptide motif responsible for the inhibition of caspase-3 apoptotic activity." Presented at 24th Annual Summer Research Opportunities Program (SROP) Confrence, Columbus, OH, US|USA. (January 2010)

"Mechanisms of cell fate during inflammation of cancer." Presented at Department of Pharmacology, Columbus, OH, US|USA. (January 2010)

"Celery extracts induce invitro inhibition of NF-?B activity and TNFa production in LPS-stimulated macrophages." Presented at 5th Annual Research Day, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Columbus, OH, US|USA. (January 2010)

"Association of caspase-3 with heat shock protein 27 regulates cellular life span of cells from the innate and adaptive immune system." Presented at Cell Death Meeting, Cold Spring Harbor, NY, US|USA. (October 2010)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at 13th Annual OSU Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at 10th Annual Ohio State University Medical Center, Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (April 2011)

"Innovative approach towards anti-inflammatory apigenin target identification." Presented at 4th Annual translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (April 2011)

"Caspases and heat shock proteins: inflammation tuning by cell death." Presented at The Davis Heart and Lung Research Institute, Columbus, OH. (November 2011)

"Regulation of apoptosis: implications for cancer and innate immunity." Presented at Stony Brook University, Stony Brook, NY, US|USA. (April 2011)

"Molecular mechanisms of anti-carcinogenic flavonoids." Presented at Natural and Mathematical Sciences Undergraduate Research Fourm, . (April 2011)

"Molecular mechanisms of anti-carcinogenic flavonoids." Presented at Denman Undergraduate Research Forum, . (May 2011)

"The role of plant small metabolite in the regulation of adipocytokine secretion and hypertrophy." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"Innovative approach towards understanding the anti-inflammatory mechanisms of the flavonoid apigenin." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"PD-Seq:Coupling phage-display with next-generation sequencing towards the identification of human cellular targets of the flavonoid apigenin and development of flavonoids nanosensors." Presented at Gordon Conference-Plant Metabolic Engineering, Waterville Valley, NH, US|USA. (July 2011)

"Role of Hsp27 in monocyte to macrophage life span and differentiation." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"Deglycosylation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at The 8th annual Russell Klein Nutrition Research Symposium, . (January 2011)

"Molecular identification of Hsp2 anti-apoptotic activity." Presented at Denman Undergraduate Research Forum, . (February 2011)

"Molecular identification of Hsp2 anti-apoptotic activity." Presented at Natural and Mathmatical Sciences Undergraduate Research Forum, . (April 2011)

"Molecular fingerprinting of Hsp27 anti-apoptotic activity." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"PKCo regulated cell death and survival through phosphorylation of caspase-3." Presented at The Davis Heart and Lung Institute Research Day, . (October 2011)

"The anti-inflammatory flavonoid apigenin reduces mortality in a mouse model of acute inflammation by inhibiting lung neutrophil infiltration and reducing MIP-2 chemokine expression." Presented at The 10th Anniversary Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2011)

"Molecular biosensor of flavonoids involved in regulation of inflammation." Presented at 4th Annual Translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (January 2011)

"Heat shock proteins and caspases in the regulation of cell fate and immunity." Presented at Tel-Aviv University, Tel-Aviv, IL|ISR. (March 2011)

"Anti-cancer and anti-inflammatory molecular mechanisms of dietary plant flavonoids." Presented at Interdepartmental Seminar in Nutrition, Columbus, OH, US|USA. (April 2011)

"The cellular fate of monocytes and macrophages is regulated by Hsp27." Presented at 4th Annual Translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (January 2011)

"Monocytes and macrophages life span is regulated by the association of caspase-3 with Hsp27." Presented at The 10th Anniversary Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (January 2011)

"Hsp27 determines the cellular life span of monocytes and macrophages." Presented at The 10th Annual Ohio State University Medical Center, Graduate and Post-Graduate Research Day, Columbus, OH, US|USA. (January 2011)

"PKCo-dependent phosphorylation of caspase-3 modulates its enzymatic activity and cell death." Presented at 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Deglycosilation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorption of dietary flavones from celery in mice." Presented at 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Deglycosilation of flavones enhances anti-inflammatory activity of food extracts in vitro and absorbtion of dietary flavones from celery in mice.." Presented at Experimental Biology, Washington, DC, US|USA. (January 2011)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at 13th OSU-Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, US|USA. (January 2011)

"Innovative approach towards bioactive anti-carcinogenic flavonoid target identification and development of biological nanosensors." Presented at The 10th Annual Ohio State University Medical Center, Graduate and Post-Graduate Research Day, Columbus, OH, US|USA. (January 2011)

"Innovative approach towards anti-inflammatory apigenin target identification." Presented at 4th Annual Translational to Clinical (T2C) Wound Care Conference, Columbus, OH, US|USA. (January 2011)

"Two to Tango: heat shock proteins and caspases in the regulation of cell fate." Presented at Department of Molecular Genetics, Columbus, OH, US|USA. (February 2011)

"Plants for health: from education and research to the clinic." Presented at Flora Braziliensis, Columbus, OH, US|USA. (February 2012)

"Role of caspase-3 in cell fate: novel partners define a complex regulatory network." Presented at International Cell Death Symposium, BR|BRA. (October 2012)

"Plants for health: regulatory networks controlling inflamation and cancer." Presented at University of Mayaguez, PR|PRI. (November 2012)

"Flavonoids-target identification and development of biosensors." Presented at B3 Tripartite OSU-Rutgers-Univeristy of Sao Paulo, Columbus, Ohio. (May 2012)

"Effect of apigenin on metabolic dysfunction in adipose tissue." Presented at OSU-Comprehensive Cancer Center Annual Scientific Meeting, . (March 2012)

"Target identificaiton and anti-carcinogenic mechanisms of dietary flavonoids." Presented at The 14th OSU-Comprehensive Cancer Center Annual Scientific Meeting, . (March 2012)

"Anti-apoptotic proteins: essential regulators of monocyte to macrophage life span and differentiation." Presented at The Davis Heart and Lung Institute Research Day, . (October 2012)

"Identification of human-flavonoid targets using an innovative approach reveals new mechanisms involved in their anti-inflamatory activities." Presented at Experimental Biology, . (April 2012)

"Target identification and regulation of innate immunity by the dietary flavonoid apigenin." Presented at Annual Scientific Meeting, . (April 2012)

"Effect of apigenin on metabolic dysfunction in adipose tissue." Presented at The 9th Annual Russell Nlein Nutrition Research Symposium, . (May 2012)

"Heat shock proteins and apoptotic caspases define complex survival and apoptotic regulatory networks controlling cell fate and inflammation." Presented at Northeast Ohio Medical University, Cleveland, OH, US|USA. (September 2012)

"Role of anti-apoptopic proteins in monocyte to macrophase life span and differentiation." Presented at The 11th Annual Ohio State University Medical Center, Graduate, Undergraduate and Postgraduate Research Day, . (April 2012)

"Molecular Fingerprinting of Hsp27 Anti-Apoptotic Activity." Presented at Experimental Biology, San Diego, CA. (April 2012)

"Moleculat identification of Hsp27 Anti-Apoptotic Activity." Presented at Denman Undergraduate Research Forum, . (April 2012)

"The role of apigenin and Hsp27 in NSCLC apoptosis." Presented at The Davis Heart and Lung Institute Research Day, . (October 2012)

"Identification of target genes regulated by the shine transcription factor in monocot plants using CHIP-Seq." Presented at Gordon Conference, NH, US|USA. (July 2013)

"Identification of human targets of the dietary flavone apigenin reveals novel aspects of the anti-carcinogenic and anti-inflammatory mechanisms of phytochemicals." Presented at Gordon Conference-Plant Metabolic Engineering, Waterville Valley, OH, US|USA. (July 2013)

"Mechanisms of breast cancer chemosensitization by dietary compounds SUCCESS program." Presented at The Ohio State University, Columbus, Ohio. (August 2013)

"Complex regulatory interactions of survival and apoptotic proteins determine cell fate by tuning caspase activity." Presented at University of Sao Paulo, Brazil, Sao Paulo, BR|BRA. (April 2013)

"MALCS-Women Active in Social Studies and Languages." Presented at "Bridging the Gap: underrepresented groups in STEM", Columbus, OH, US|USA. (July 2013)

"Regulation of casapse-3 by the anti-apoptotic proteins XIAP and Hsp27." Presented at SROP, Columbus, Ohio. (July 2013)

"Using the yeast of two-hybrid systems to determne caspase-3 prodomian interaction with hsp27." Presented at REU-Molecular Genetics/Biochemistry, Columbus, Ohio. (August 2013)

"Anti-apoptopic proteins: essential regulators of monocyte to macrophage life span and differentiation." Presented at The 12th Annual Ohio State University Medical Center, Graduate and Postgraduate Trainee Research Day, . (April 2013)

"The role of apigenin and Hsp27 in NSCLC apoptosis." Presented at Denman Undergraduate Research Forum, . (April 2013)

"The identification of regulatory networks that control phenolic biosynthesis in maize." Presented at 55th Annual Maize Genetics Conference, . (March 2013)

"Approaches to identify gene regulatory networks in grasses." Presented at 55th Annual Maize Genetics Conference, . (March 2013)

"Target identification of Dietary Flavonoids Reveals Novel Mechanisms Involved in Their Anti-Carcinogenic Activity." Presented at The 10th Annual Russel Klein Nutrition Research Symposium, . (March 2013)

"1st Place Graduate Student Category." Presented at The 12th Annual Ohio State University Medical Center, Graduate and Postgraduate Trainee Research Day, . (April 2013)

"Identification of human targets of the dietary flavone apigenin reveals novel aspects of the anti-carcinogenic and anti-inflammatory mechanisms of phytochemicals." Presented at Gordon Conference-Plant Metabolic Engineering, Waterville Valley, NH, US|USA. (July 2013)

"Mechanisms and functional significance of bioactive food components in mitochondrial dysfunction: potential new translational approaches in inflammation-induced metabolic disorders." Presented at The 12th Annual Ohio State University Medical Center, Graduate and Postgraduate Research Day, . (April 2013)

"The role of apigenin and Hsp27 in NSCLC apoptosis." Presented at Natural and Mathematical Sciences Undergraduate Research Forum, . (April 2013)

 

Professional Activities

present 4th Annual Translational to Clinical (T2C) Wound Care Conference. The Ohio State University Medical Center. Columbus, OH.
present Biological, Mathematical, and Physical Sciences Undergraduate Research Forum. The Ohio State University Medical Center. Columbus, OH.
present The 10th Anniversary David Heart and Lung Research Institute Research Day. The Ohio State University Medical Center. Columbus, OH.
present Dr. Patricia Finn. University of California. San Diego, CA.
present Dr. Robert Schleimer. Northwestern University. Chicago, IL.
present Medical Center Research Day. The Ohio State University Medical Center. Columbus, OH.
present Dr. David Dockrell. University of Sheffield.
present Dr. Vincent Cryns. Northwestern University. Chicgo, IL.
present 5th Annual Research Day, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine. The Ohio State University Medical Center. Columbus, OH.
present Finding your faculty career niche.. The Ohio State University.
present Finding your faculty career niche. The Ohio State University.
present Dr. Johaness Tesfaigzi. Lovelace Respiratory Research Institute. Albuquerque, NM.
present Natural and Mathematical Sciences Undergraduate Research Forum. The Ohio State University.
present The Davis Heart and Lung Research Day. The Ohio State University. Columbus, OH.
present The Davis Heart and Lung Research Day. The Ohio State University Medical Center. Columbus, OH.
2007 - present National Institute of Health. Lung Cellular, and Immunobiology Study Section.
2007 - present National Science Foundation: Molecular Cellular Biology-Panel II Cellular Signalling.
2007 - present American Heart Association. Columbus, OH.
2008 - present Co Chair Basic Cell and Molecular Biology. American Heart Association-Great Rivers Area.
2001 - 2005 American Thoracic Society - Allergy and Immunology Assembly Program Committee..
2007 - 2008 American Heart Association-Great Rivers Valley Area.
2007 - 2009 Davis Heart & Lung Research Institute.
2006 - 2013 Division of Pulmonary and Critical Care.
 

Unpublished Works

Arango, D., Mejia-Guerra, K., Grotewold, E., and Doseff, A.I.. Genome-wide regulation of alternative splicing by dietary apigenin controls anti-apoptotic-associated resistance in breast cancer.. March 2015.

Cardenas, H.*, Arango, D.*, Nicholas, C., Duarte, S., Gonzalez-Mejia, E., Nuovo, G., and Grotewold, E., Doseff, A.I.. Dietary apigenin regulates lipopolysaccharide-induced pulmonary inflammation by restoring metabolic function and reducing leukocyte infiltration. *Indicates shared first authorship.. June 2015.

Voss, O., Tossey, J., Arango, D., Grotewold, E., and Doseff, A.I.. Chemo-sensitization of lung cancer by dietary apigenin through changes in alternative splicing promoting the activation of DISC formation.. May 2015.

Mejia-Guerra, K., Li, Wei, Doseff, A.I.# and Grotewold, E#.. Core promoter plasticity between maize tissues and genotypes contrasts with predominance of sharp transcription initiation sites. #Indicates shared corresponding author. July 2015.

Gonzalez-Mejia, E., Voss, O.H., and Doseff, A.I. Phosphorylation of Hsp27 during apoptosis mediates PKCo-dependent phosphorylation of caspase-3. February 2015.

Arango, D., Pereira, M., Duarte, S., Jung, V., and Doseff, A.I.. NFkB-dependent regulation of proliferative and immune-regulatory activity of dietary apigenin in breast cancer.. April 2015.

Voss, O.H., Malavez, Y., and Doseff, A.I. Specific docking sites of PKCo on caspase-3 induce phosphorylation and positively regulates apoptosis.. January 2015.