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Anasuya Sarkar, PhD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 688-8268

Email: sarkar.10@osu.edu

 

Current OSU Appointment

Research Assistant Professor, Pulm,Allergy,Crit Care & Sleep

 

Chapters in Books

Sarkar A and Wewers MD. "Toll-like Receptors: Pathogen sensors that revolutionized innate immunity.." In Regulation of Innate Immune Function. -. Columbus: Research Signpost, January 2010.

 

Degrees

2004 Ph.D., Jadavpur University

 

Honors

1993 National level merit award. University of Calcutta.
1996 Outstanding student. University of Calcutta.
1998 Gold Medal. University of Calcutta.
1998 - 2000 Junior Research Fellowship. Council of Scientific and Industrial Research (CSIR).
1999 Best poster award. Society of Biological Chemists (India).
2000 - 2002 Senior Research Fellow. Center of Scientific and Industrial Research (CSIR).
2001 Best poster award. International Conference on Natural Antioxidants and Free Radicals in Human Health and Radiation Biology NFHR-2001.
2005 NIH Post Doctoral Travel Scholarship. NIH Post Doctoral Travel Scholarship and Keystone Symposium.
2006 Best poster award. Dorothy M. Davis Heart and Lung Research Institute.
2006 Best poster award. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine.
2006 Best poster award. 5th Annual OSUMC Graduate and Postgraduate Research Day, The Ohio State University.
2006 - 2007 Distinguished Post Doctoral Award. Dorothy M. Davis Heart and Lung Research Institute.
2007 Best oral presentation award. Dorothy M. Davis Heart and Lung Research Institute.
2008 Best Poster Award. Division of Pulmonary, Allergy, Critical care and Sleep Medicine.
2008 American Thoracic Society (ATS) Travel Award. ATS 2008, Toronto, Canada.
2010 - 2011 ARDS Scholar Award.
 

Journal Articles

Sarkar A; Bhaduri A. "Black tea is a powerful chemopreventor of reactive oxygen and nitrogen species: comparison with its individual catechin constituents and green tea.." Biochemical And Biophysical Research Communications. Vol. 284, no. 1. (June 2001.): 173-.

Sarkar A; Hall MW; Exline M; Hart J; Knatz N; Gatson NT; Wewers MD. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.." American Journal Of Respiratory And Critical Care Medicine. Vol. 174, no. 9. (November 2006.): 1003-.

Sarkar A; Duncan M; Hart J; Hertlein E; Guttridge DC; Wewers MD. "ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions.." Journal Of Immunology (Baltimore, Md.: 1950). Vol. 176, no. 8. (April 2006.): 4979-.

Schmittgen TD, Lee FJ, Jiang J, Sarkar A, Yang L, Elton TS and Chen C. "Real-time PCR quantification of precursor and mature microRNA,." Methods. Vol. 1, no. 44. (January 2008.): 31-38.

Fahy RJ, Exline MC, Gavrilin MA, Bhatt NY, Besecker BY, Sarkar A, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall M, Wewers MD. "Inflammasome mRNA expression in human monocytes during early septic shock.." Am J Respir Crit Care Med.. Vol. 9, no. 177. (May 2008.): 983-988.

Swaan PW, Bensman T, Bahadduri PM, Hall MW, Sarkar A, Bao S, Khantwal CM, Ekins S and Knoell DL. "Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.." Am. J Respir. Cell Mol. Biol.. Vol. 5, no. 39. (November 2008.): 536-542.

Raices RM, Kannan Y, Sarkar A, Bellamkonda-Athmaram V, Wewers MD. "A synergistic role for IL-1beta and TNFalpha in monocyte derived IFNgamma inducing activity.." Cytokine. Vol. 2, no. 44. (November 2008.): 234-241.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.." PLoS Pathogen. no. Apr;5(4):e1000361. (January 2009.): -.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.." PLoS Pathog.. Vol. 4, no. 5. (April 2009.): e1000361-.

Sarkar A, Mitra S, Mehta S, Raices R, Wewers MD. "Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1." PLoS One. Vol. 9, no. 4. (September 2009.): e7140-.

Wewers MD and Sarkar A. "P2X7 receptor and macrophage function.." Purinergic Signal.. Vol. 2, no. 5. (June 2009.): 189-195.

Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD, Tracey KJ, Kanneganti TD, Dixit VM. "Inflammasome dependent release of the Alarmin HMGB1 in endotoxemia.." Journal of Immunology. no. 185(7):4385-92. (January 2010.): -.

Miao EA, Leaf IA, Treuting P, Mao DP, Dors M, Sarkar A, Wewers M, Aderem A. "Caspase-1 induced pyroptosis clears intracellular bacteria independent of IL-1β/IL-18 in vivo.." Nat Immunol.. no. 11(12):1136-42.. (January 2010.): -.

Sarkar A, Exline M, Berhe F, Hollyfield J, Beesecker B and Wewers M. "Circulatory Microvesicular Caspase-1 and Lymphocyte Death in Sepsis." AJRCCM. no. manuscript in preparation. (January 2011.): -.

 

Reference Works

January 1999 Sarkar A and Bhaduri A."Theaflavin in black tea as a powerful chemopreventor." .
January 2001 Sarkar A and Bhaduri A."Black tea and flavonoids." .
January 2005 Sarkar A, Hart J, Hertlein E, Guttridge D and Wewers M."ASC is a dual regulator in caspase-1 mediated inflammation and NF-B activation." .
January 2005 Sarkar A, Hall M, Hart J and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality." .
January 2006 Sarkar A, Hall M, Exline M, Hart J, Knatz N, Gatso N and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality and splenic cell apoptosis unlike IL-1b knockout and IL-1b/IL-18 double knockout" .
January 2006 Sarkar A, Hall M, Exline M, Hart J, Knatz N, Gatso N and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality and splenic cell apoptosis unlike IL-1b knockout and IL-1b/IL-18 double knockout." .
January 2006 Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge D and Wewers M."ASC direct NF-kappaB activation by regulating RIP2/caspase-1 interactions." .
January 2006 Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge D and Wewers M."ASC direct NF-kappa B activation by regulating RIP2/caspase-1 interactions." .
January 2006 Sarkar A, Bao S, Raices R, Bensman T, Wewers MD and Knoell D."NOD like receptor proteins coordinate the inflammasome response in human lung epithelial cells." .
January 2006 Raices R, Sarkar A, Bao S, Bensman T, Hart J, Knoell D and Wewers MD."Relative Ability of Lung Epithelial Cells and Monocytes to Sense TLR Ligands." .
January 2006 Raices R, Sarkar A and Wewers MD."Identification of a monocyte-derived, IL-18-like, IFN-γ inducing factor" .
January 2006 Raices R, Sarkar A and Wewers MD."Identification of a monocyte-derived, IL-18-like, IFN-γ inducing factor." .
January 2007 Raices R, Sarkar A and Wewers MD."Interleukin-1β, not Interleukin-18, is the primary product of LPS-stimulated human monocytes required for IFN-γ release by KG-1 cells." .
January 2007 Sarkar A, Raices R, Hall MW, Mitra S and Wewers MD."Role of tyrosine kinase in regulating LPS priming associated with caspase1 activation and sepsis response." .
January 2007 Sarkar A, Raices R, Hall MW, Mitra S and Wewers MD."Role of tyrosine kinase in regulating LPS priming associated with caspase1 activation and sepsis response." .
January 2008 Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Monocyte derived microvesicles containing caspase-1 mediate smooth muscle cell apoptosis." .
January 2008 Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Monocyte derived microvesicles containing caspase-1 mediate smooth muscle cell apoptosis." .
January 2008 Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Microvesicular caspase-1 as death messenger to vascular smooth muscle cells." .
January 2009 A Sarkar, S Mitra and M.D. Wewers."Release of caspase-1 and IL-1beta in microvesicles regulated by ATP ion channels" .
January 2009 A Sarkar, S Mitra and M.D. Wewers."Release of caspase-1 and IL-1beta in microvesicles regulated by ATP ion channels" .
January 2010 M.C. Exline, A. Sarkar, B.Y. Besecker, J.L. Hollyfield, S. Mitra, M.D. Wewers."Inflammasome Constituents Released Via Microvesicles During Sepsis" .
January 2011 A Sarkar, F Berhe, S Mitra and M.D. Wewers."IL-1b Release Rrom Intact Microvesicles Is Regulated Extracellularly By ATP Ion Channels" .

Presentations

"Inflammasome Constituents Released Via Microvesicles During Sepsis." Presented at ATS 2010, . (May 2010)

"Microvesicular Death Messages." Presented at ATS 2011 minisymposium-SENSORS, DANGER SIGNALS, PEPTIDES AND CELL SUICIDE: NEW CONCEPTS OF HOST INFECTION CONTROL, . (January 2011)

"IL-1B Release From Intact Microvesicles Is Regulated Extracellularly By ATP Ion Channels." Presented at ATS 2011- PATHOGENESIS OF ACUTE LUNG INJURY, . (January 2011)

 

Professional Activities

2009 - present Leukemia and Lymphoma Society- Capital City Half Marathon.
2010 - present Capital City Half Marathon-Leukemia and Lymphoma Society.
2010 - present The Ohio State University.
2011 - present Judge. The Ohio State University.