Anasuya Sarker, PhD

Current OSU Appointment

Research Assistant Professor, Pulm,Allergy,Crit Care & Sleep

Chapters in Books

Sarkar A and Wewers MD. "Toll-like Receptors: Pathogen sensors that revolutionized innate immunity.." In Regulation of Innate Immune Function. -. Columbus: Research Signpost, January 2010.

Journal Articles

Sarkar A; Bhaduri A. "Black tea is a powerful chemopreventor of reactive oxygen and nitrogen species: comparison with its individual catechin constituents and green tea.." Biochemical And Biophysical Research Communications. Vol. 284, no. 1. (June 2001.): 173-.

Sarkar A; Duncan M; Hart J; Hertlein E; Guttridge DC; Wewers MD. "ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions.." Journal Of Immunology (Baltimore, Md.: 1950). Vol. 176, no. 8. (April 2006.): 4979-.

Sarkar A; Hall MW; Exline M; Hart J; Knatz N; Gatson NT; Wewers MD. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.." American Journal Of Respiratory And Critical Care Medicine. Vol. 174, no. 9. (November 2006.): 1003-.

Schmittgen TD, Lee FJ, Jiang J, Sarkar A, Yang L, Elton TS and Chen C. "Real-time PCR quantification of precursor and mature microRNA,." Methods. Vol. 1, no. 44. (January 2008.): 31-38.

Fahy RJ, Exline MC, Gavrilin MA, Bhatt NY, Besecker BY, Sarkar A, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall M, Wewers MD. "Inflammasome mRNA expression in human monocytes during early septic shock.." Am J Respir Crit Care Med.. Vol. 9, no. 177. (May 2008.): 983-988.

Swaan PW, Bensman T, Bahadduri PM, Hall MW, Sarkar A, Bao S, Khantwal CM, Ekins S and Knoell DL. "Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.." Am. J Respir. Cell Mol. Biol.. Vol. 5, no. 39. (November 2008.): 536-542.

Raices RM, Kannan Y, Sarkar A, Bellamkonda-Athmaram V, Wewers MD. "A synergistic role for IL-1beta and TNFalpha in monocyte derived IFNgamma inducing activity.." Cytokine. Vol. 2, no. 44. (November 2008.): 234-241.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.." PLoS Pathogen. no. Apr;5(4):e1000361. (January 2009.): -.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.." PLoS Pathog.. Vol. 4, no. 5. (April 2009.): e1000361-.

Sarkar A, Mitra S, Mehta S, Raices R, Wewers MD. "Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1." PLoS One. Vol. 9, no. 4. (September 2009.): e7140-.

Wewers MD and Sarkar A. "P2X7 receptor and macrophage function.." Purinergic Signal.. Vol. 2, no. 5. (June 2009.): 189-195.

Miao EA, Leaf IA, Treuting P, Mao DP, Dors M, Sarkar A, Wewers M, Aderem A. "Caspase-1 induced pyroptosis clears intracellular bacteria independent of IL-1β/IL-18 in vivo.." Nat Immunol.. no. 11(12):1136-42.. (January 2010.): -.

Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD, Tracey KJ, Kanneganti TD, Dixit VM. "Inflammasome dependent release of the Alarmin HMGB1 in endotoxemia.." Journal of Immunology. no. 185(7):4385-92. (January 2010.): -.

Sarkar A, Exline M, Berhe F, Hollyfield J, Beesecker B and Wewers M. "Circulatory Microvesicular Caspase-1 and Lymphocyte Death in Sepsis." AJRCCM. no. manuscript in preparation. (January 2011.): -.

Reference Works

January 1999	Sarkar A and Bhaduri A."Theaflavin in black tea as a powerful chemopreventor." .
January 2001	Sarkar A and Bhaduri A."Black tea and flavonoids." .
January 2005	Sarkar A, Hart J, Hertlein E, Guttridge D and Wewers M."ASC is a dual regulator in caspase-1 mediated inflammation and NF-B activation." .
January 2005	Sarkar A, Hall M, Hart J and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality." .
January 2006	Raices R, Sarkar A, Bao S, Bensman T, Hart J, Knoell D and Wewers MD."Relative Ability of Lung Epithelial Cells and Monocytes to Sense TLR Ligands." .
January 2006	Raices R, Sarkar A and Wewers MD."Identification of a monocyte-derived, IL-18-like, IFN-γ inducing factor" .
January 2006	Raices R, Sarkar A and Wewers MD."Identification of a monocyte-derived, IL-18-like, IFN-γ inducing factor." .
January 2006	Sarkar A, Hall M, Exline M, Hart J, Knatz N, Gatso N and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality and splenic cell apoptosis unlike IL-1b knockout and IL-1b/IL-18 double knockout" .
January 2006	Sarkar A, Hall M, Exline M, Hart J, Knatz N, Gatso N and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality and splenic cell apoptosis unlike IL-1b knockout and IL-1b/IL-18 double knockout." .
January 2006	Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge D and Wewers M."ASC direct NF-kappaB activation by regulating RIP2/caspase-1 interactions." .
January 2006	Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge D and Wewers M."ASC direct NF-kappa B activation by regulating RIP2/caspase-1 interactions." .
January 2006	Sarkar A, Bao S, Raices R, Bensman T, Wewers MD and Knoell D."NOD like receptor proteins coordinate the inflammasome response in human lung epithelial cells." .
January 2007	Sarkar A, Raices R, Hall MW, Mitra S and Wewers MD."Role of tyrosine kinase in regulating LPS priming associated with caspase1 activation and sepsis response." .
January 2007	Sarkar A, Raices R, Hall MW, Mitra S and Wewers MD."Role of tyrosine kinase in regulating LPS priming associated with caspase1 activation and sepsis response." .
January 2007	Raices R, Sarkar A and Wewers MD."Interleukin-1β, not Interleukin-18, is the primary product of LPS-stimulated human monocytes required for IFN-γ release by KG-1 cells." .
January 2008	Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Monocyte derived microvesicles containing caspase-1 mediate smooth muscle cell apoptosis." .
January 2008	Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Monocyte derived microvesicles containing caspase-1 mediate smooth muscle cell apoptosis." .
January 2008	Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Microvesicular caspase-1 as death messenger to vascular smooth muscle cells." .
January 2009	A Sarkar, S Mitra and M.D. Wewers."Release of caspase-1 and IL-1beta in microvesicles regulated by ATP ion channels" .
January 2009	A Sarkar, S Mitra and M.D. Wewers."Release of caspase-1 and IL-1beta in microvesicles regulated by ATP ion channels" .
January 2010	M.C. Exline, A. Sarkar, B.Y. Besecker, J.L. Hollyfield, S. Mitra, M.D. Wewers."Inflammasome Constituents Released Via Microvesicles During Sepsis" .
January 2011	A Sarkar, F Berhe, S Mitra and M.D. Wewers."IL-1b Release Rrom Intact Microvesicles Is Regulated Extracellularly By ATP Ion Channels" .

Presentations

"Inflammasome Constituents Released Via Microvesicles During Sepsis." Presented at ATS 2010, . (May 2010)

"Microvesicular Death Messages." Presented at ATS 2011 minisymposium-SENSORS, DANGER SIGNALS, PEPTIDES AND CELL SUICIDE: NEW CONCEPTS OF HOST INFECTION CONTROL, . (January 2011)

"IL-1B Release From Intact Microvesicles Is Regulated Extracellularly By ATP Ion Channels." Presented at ATS 2011- PATHOGENESIS OF ACUTE LUNG INJURY, . (January 2011)