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Tim Eubank, Ph.D.
Research Assistant Professor
201 Davis Heart & Lung Research Institute
473 West 12th Avenue
Columbus, OH 43210
(614) 247-7652
Education:
2003 Ph.D. The Ohio State Biochemistry Program, The Ohio State University
Mentor:
Clay B. Marsh, MD
Research Interests:
Mechanisms of breast cancer growth and metastases; angiogenesis; malignant melanoma;
tumor-associated macrophages; tumor microenvironment
Awards and Honors:
2009 Outstanding Laboratory Research Poster, 2009 Symposium on Advanced Wound Care, Dallas TX
2007 Outstanding Poster, Faculty/Research Scientist Division, 2nd Annual Pulmonary Research Day
2006 Chief Post-doctoral Fellow, the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine
2005 Davis Heart & Lung Research Institute Distinguished Post-Doctoral Researcher of the Year
Journal Review:
2009 Wound Healing Society Year Book – Advances in Wound Care
International Journal of Cancer
Blood Journal
PLoS ONE
Miscellaneous Activities:
Science illustrator for the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine
- Original cover art selected for AMJRCCM and J Thoracic Oncology
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Grant Awards:
Current: NIH/NCI 1 K99 CA131552-01
K99/R00 Pathway to Independence Role: PI
Current: NIH/NCI 1R21CA132068-02 Role: Co-I
Completed: NIH/NCI 1R21CA132068-01 Role: Co-I
Completed: OSU DHLRI Internal Funding Role: PI
Completed: NIH/NHLBI T32 HL07946-01 Role: Fellow
Peer-reviewed Publications:
Books:
1. Eubank TD and Marsh CB. Cytokines and Growth Factors in the Regulation of Wound Inflammation. Advances in
Wound Care: Volume 1. 2009. WHS Yearbook Series: The Benchmark Interdisciplinary Digest for a Broad Readership – From Clinicians to Graduate Students. [In Press].
Journals:
1. Sliman S, Eubank TD, Ryan, Thomas, Kotha S, Sherwani S, Butler S, Roy S, Kuppusamy P, Marsh C, Parinandi N. Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: Aminoguanidine protection. Molecular and Cellular Biochemistry. 2009
[In Press].
2. Bobko AA, Dhimitruka I, Eubank TD, Marsh CB, Zweier JL, Khramtsov VV. Trityl-based EPR probe with enhanced
sensitivity to oxygen. Free Radic Biol Med. 2009 Jun 9. [In Press].
3. Eubank TD and Roberts RD, Khan M, Curry JM, Nuovo GJ, Kuppusamy P, and Marsh CB. GM-CSF inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages. Cancer Res. 2009 Mar 1;69(5):2133-40
4. Hunter M, Wang Y, Eubank T, Baran C, Nan-Sinkham P, Marsh C. Myeloid Cell Survival and its Role in Health and Disease. Front Biosci. 2009 Jan 1;14:4079-102. Review.
5. Curry JM and Eubank TD, Roberts RD, Wang Y, Pore N, Maity A, Marsh CB. M-CSF signals through the MAPK/ERK
pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo. 2008. PLoS ONE, Oct 14;3(10).
6. Ali NA, Gaughan AA, Orosz CG, Baran CP, McMaken S, Wang Y, Eubank TD, Hunter M, Lichtenberger FJ, Flavahan NA,
Lawler J, Marsh CB. Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1.
2008. PLoS ONE, Apr 2;3(4).
7. Bringardner BD, Baran CP, Eubank TD, Marsh CB. The Role of Inflammation in the Pathogenesis of Idiopathic
Pulmonary Fibrosis. Antioxid Redox Signal. 2007 Volume 10, Number 2.
8. Parinandi NL, Sharma A, Eubank TD, Kaufman BF, Kutala VK, Marsh CB, Ignarro LJ, Kuppusamy P. Nitroaspirin (NCX-
4016), an NO Donor, is Antiangiogenic Through Induction of Loss of Redox-Dependant Viability and Cytoskeletal
Reorganization in Endothelial Cells. Antioxid Redox Signal. 2007 Aug 30.
9. Wang Y, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, Tridandapani S, Sen CK, Marsh CB. The Role of
the NADPH Oxidase Complex, p38 MAPK and Akt in Regulating Human Monocyte/Macrophage Survival. Am J Respir Cell Mol Biol. 2007 Jan;36(1):68-77.
10. Yang EV, Sood AK, Chen M, Yeh P, Eubank TD, Marsh CB, Jewell S, Flavahan NA, Morrison C, Glaser R.
Norepinephrine up-regulates the expression of VEGF, MMP-2 and MMP-9 in nasopharyngeal carcinoma tumor cells.
2006. Cancer Research, Nov 1;66(21):10357-64.
11. Eubank TD, Roberts R, Galloway M, Wang Y, Cohn DE, Marsh CB. GM-CSF Induces Expression of Soluble VEGF
Receptor-1 from Human Monocytes and Inhibits Angiogenesis in Mice. 2004. Immunity, 21:831-842.
12. Eubank TD, Galloway M, Montague CM, Waldman WJ, Marsh CB. M-CSF induces vascular endothelial growth factor
production and angiogenic activity from human monocytes. 2003. The Journal of Immunology, 171: 2637-2643.
13. Eubank TD, Biswas R, Jovanovic M, Litovchick A, Lapidot A, Gopalan V. Inhibition of bacterial RNase P by
aminoglycoside-arginine conjugates. 2002. FEBS Letters, 511: 107-12.
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