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Chris Baran, Ph.D.
Research Assistant Professor
201 Davis Heart & Lung Research Institute
473 West 12th Avenue
Columbus, OH 43210
(614) 366-1332
Christopher Baran, PhD is a Research Assistant Professor of Internal Medicine in the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine. He is also an Associate Investigator of the Davis Heart and Lung Research Institute.
Chris joined the faculty at The Ohio State University as a Research Scientist in 2006 and as a Research Assistant Professor in 2009. He currently maintains an R03 grant that is funded by the National Heart, Lung, and Blood Institute and is the director of the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine’s bi-weekly Research Conference.
Education :
B.A., Chemistry and Business ,Washington and Jefferson College, 1997
PhD, Biochemistry, The Ohio State University, 2003
Mentor: Clay Marsh, MD
Research Interests:
The function of macrophages, fibrocytes, and myofibroblasts in the development of idiopathic pulmonary fibrosis (IPF) is the central theme of Dr. Baran’s research. He is currently studying the importance of the transcription factor ets-2 in the expression of type-I collagen, alpha smooth muscle actin (?SMA), and connective tissue growth factor (CTGF) in fibrotic lung disease and the activation of ets-2 and its role in the pathogenesis of IPF. His research has been expanded to include the study of ets-2 in the maturation, differentiation, and proliferation of myofibroblasts and the role of the inositol phosphatase PTEN in regulation myofibroblast functions. Through his collaborative efforts within the Division, Dr. Baran also has an interest in translational research in the fields of exercise-induced bronchospasm, lung transplantation, and pulmonary hypertension. Recent studies have highlighted the possibilities of targeting ets-2 in the treatment of IPF.
Grant Awards:
T32 HL07946-01, Wewers (PI) 2004 – 2006 NIH / NHLBI, Role: Post-doctoral Fellow
Reference List
1. Christopher P. Baran, Gerard J. Nuovo, Sara N. Fischer, Mohamed N. Kabbout, Benjamin D. Bringardner, Sara McMaken, Carmen Cantemir, Sudarshana Sharma, Christie A. Newland, Shannon R. Wells, Gary S. Phillips, Michael C. Ostrowski, and Clay B. Marsh. The transcription factor ets-2 is important in the pathogenesis of pulmonary fibrosis in mice and humans. (2009). In review.
2. Hunter M, Wang Y, Eubank T, Baran C, Nana-Sinkam P, and Marsh C. Survival of monocytes and macrophages and their role in health and disease. (2009) Frontiers in Bioscience. (14) 4079-4102.
3. Jonathan P. Parsons, Christopher P. Baran, Gary Phillips, David Jarjoura, Christopher Kaeding, Benjamin Bringardner, Gail Wadley, Clay B. Marsh, and John G. Mastronarde. Airway inflammation in exercise-induced bronchospasm occurring in athletes without asthma. (2008) Journal of Asthma. 45 (5) 363-367.
4. A.C. Gregory*, Christopher P. Baran*, M. Kuppusamy, E. Steinhour, R. Rajappan, U. Magalang, P. Kuppusamy, D. Romberger, C.B. Marsh, and N.L. Parinandi. Swine farm particulate matter is a potent stimulator of reactive oxygen species formation by macrophages. (in preparation)
5. Naeem A. Ali, Alice A. Gaughan, Charles G. Orosz, Christopher P. Baran, Sara McMaken, Yijie Wang, Timothy D. Eubank, Melissa g. Hunter, Frank J. Lichtenberger, Nicholas A. Flavahan, Jack Lawler, Clay B. Marsh. Latency Associated Peptide has In Vitro and In Vivo Immune Effects Independent of TGF-β1. (2008) PLoS ONE. 3(4): e1914.
6. Christopher P. Baran, Benjamin D. Bringardner, Mohamed Kabbout, Sara McMaken, Gary Philips, Susie Jones, Christie A. Newland, Carrie A. Schrader, Michael C. Ostrowski, and Clay B. Marsh. The transcription factor ets-2 directs M-CSF-induced CCL12 secretion and is important in the pathogenesis of pulmonary fibrosis. (2008) American Journal of Respiratory and Critical Care Medicine IN REVIEW.
7. Benjamin D. Bringardner, Christopher P. Baran, T.D. Eubank, and C.B. Marsh. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis (2007). Antioxidant and Redox Signaling. 10 (2), 287-301.
8. Christopher P. Baran, J.M. Opalek, S. McMaken, C.A. Newland, M.G. Hunter, J.M. O’Brien, B.D. Bringardner, M.M. Monick, D.R. Brigstock, P.C. Stromberg, G.W. Hunninghake, and C.B. Marsh. Important roles for M-CSF, CCL2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. (2007) American Journal of Respiratory and Critical Care Medicine. 176 (1), 78-89.
9. Nitin Bhatt, Christopher P. Baran, J. Allen, C. Magro, and C.B. Marsh. Promosing pharmacologic innovations in treating pulmonary fibrosis. (2006) Current Opinion in Pharmacology 6 (3), 284-92.
10. S. Varadharaj, E. Steinhour, M.G. Hunter, T. Watkins, Christopher P. Baran, U. Magalang, P. Kuppusamy, J.L. Zweier, C.B. Marsh, V. Natarajan, and N.L. Parinandi. Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: Regulation by MAP kinases. (2006). Cell Signaling 18(9), 1396-1407.
11. Christopher P. Baran, M.M. Zeigler, S. Tridandapani, and C.B. Marsh. The Role of ROS and RNS in regulating life and death of blood monocytes. (2004) Current Pharmaceutical Design 8, 855-66.
12. Christopher P. Baran, S. Tridandapani, C.D. Helgason, R.K. Humphries, G. Krystal, and C.B. Marsh. The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. (2003) The Journal Biological Chemistry 278, 38628-36.
13. S. Tridandapani, R. Wardrop, Christopher P. Baran, Y. Wang, J.M. Opalek, M.A. Caliguiri, and C.B. Marsh. TGF-?1 suppresses myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit. (2003) The Journal of Immunology 170, 4572-7.
14. I-M Chiu, K. Touhalisky, and Christopher Baran. Multiple controlling mechanisms of FGF1 gene expression through multiple tissue-specific promoters. (2001) Progress in Nucleic Acids Research and Molecular Biology. 70, 155-74.
Awards and Honors:
2002 Outstanding presenter at Bennett Graduate Research Society Meeting for The Ohio State University College of Medicine and Public Health
2004 Appointed position as a Post-doctoral Fellow for the Department of Internal Medicine
2006 Member of the American Thoracic Society
2006 Selected for Oral Presentation for the 2006 American Thoracic Society Meeting: Clinical Minisymposium on Idiopathic Pulmonary Fibrosis
2006 1st Place: Outstanding faculty research presentation. 1st Annual Pulmonary Research Conference. Columbus, OH
2007 1st Place: Outstanding Research Scientist Presentation. The Dorothy M. Davis Heart and Lung Research Institute Research Symposium, The Ohio State University College of Medicine. Columbus, OH
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