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Virginia A. Folcik Nivar, Ph.D.
Research Scientist
201 Davis Heart & Lung Research Institute
473 West 12th Avenue
Columbus, OH 43210
(614) 366-1332
Education:
2005 B.S. Computer Science and Engineering, Magna Cum Laude, Ohio State Univ.
1993 Ph.D. Regulatory Biology, Summa Cum Laude, Cleveland State Univ.
1988 B.S. Biology, Medical Technology, Magna Cum Laude, Cleveland State Univ.
Post Doctoral Positions:
1993-1996 Postdoctoral Fellow, Dept. of Cell Biology, Lerner Research Institute
of the Cleveland Clinic Foundation, Cleveland, OH
1996-1998 Postdoctoral Fellow, Dept. of Neurosciences, Lerner Research Institute
of the Cleveland Clinic Foundation, Cleveland, OH
2000-2005 Student, OSU, Columbus, OH
2002-2005 Student Programmer, Transplant Surgery, OSUMC, Columbus, OH
2005-2006 Research Scientist, P.I., Transplant Surgery, OSUMC, Columbus, OH
2007-Present Research Scientist, P.I., Internal Medicine, PACCS, OSUMC, Columbus, OH
Research Interests:
Immunology of atherosclerosis, mechanisms of lipid oxidation in atherosclerosis;
mechanisms of disease pathology in multiple sclerosis; computer modeling
(agent-based modeling) of the immune system and other complex systems;
using agent-based modeling to study mechanisms of interstitial lung disease.
Grant Awards:
1993 One year fellowship grant from the American Heart Association, Northeast Ohio Affiliate.
1994 Three year National Research Service Award from the National Heart, Lung and Blood
Institute of the National Institutes of Health.
2006 Ohio State University, Technology Education Learning Research, Research on Research,
Student-Faculty ePartenership Grant (Student: Christina Sass)
http://digitalunion.osu.edu/r2/summer06/sass/
2009 Award Number R21HL093675-01 from the National Heart, Lung and Blood Institute of the
National Institutes of Health, issued under the ARRA of 2009. Title: Agent-Based Modeling
to Reveal Mechanisms of Idiopathic Interstitial Lung Disease.
Publications:
Folcik, V.A. and M.K. Cathcart, 1992. Assessment of 5-lipoxygenase involvement in human
monocyte-mediated LDL oxidation. J. Lipid Res. 34:69-79.
Folcik, V.A. and M.K. Cathcart, 1994. Predominance of esterified hydroperoxy-linoleic acid
in human monocyte-oxidized LDL. J. Lipid Res. 35:1570-1582.
Folcik, V.A., R.A. Nivar-Aristy, L. Krajewski, and M.K. Cathcart, 1995. Lipoxygenase
contributes to the oxidation of lipids in human atherosclerotic plaques.
J. Clin. Invest. 96:504-510.
Folcik, V.A., R. Aamir and M.K. Cathcart. 1997. Cytokine modulation of LDL oxidation
by activated human monocytes. Arterioscler. Thromb. Vasc. Biol. 17:1954-1961.
Sorensen, T.L., Tani, M., Jensen, J., Pierce, V., Lucchinetti, C., Folcik, V.A., Qin, S.,
Sellebjerg, F., Strieter, R., Frederiksen, J., Ransohoff, R.M. 1999. Expression of specific
chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.
J. Clin. Invest. 97(1-2):119-128.
Folcik, V.A., T. Smith, S. O’Bryant, J.A. Kawczak, B. Zhu, J. Bradshaw, H. Sakurai, A. Kajiwara,
J.M. Staddon, A. Glabinski, A.L. Chernosky, M. Tani, J.M. Johnson, V.K. Tuohy, L.L. Rubin,
and R.M. Ransohoff. 1999. Treatment with BBB022A or Rolipram stabilizes the blood-brain barrier
in experimental autoimmune encephalomyelitis: An additional mechanism for the effect of type IV
phosphodiesterase inhibitors. J. Neuroimmunology. 97:119-128.
Cathcart, M.K. and Folcik, V.A. 2000. Lipoxygenases and atherosclerosis: Protection versus
pathogenesis. Free Radical Biology and Medicine. 28(12):1726-1734.
Folcik, V.A., An, G.C. and Orosz, C.G. 2007 The Basic Immune Simulator: An agent-based model
to study the interactions between innate and adaptive immunity.
Theoretical Biology and Medical Modelling. 4:39.
Abstracts and Presentations:
Charles G. Orosz and Virginia A. Folcik. 2004. Simulating the Complexity of the Immune Response.
http://mbi.osu.edu/2003/ws5abstracts.html
Virginia A. Folcik and Charles G. Orosz. 2004. The Immune System as a Complex Adaptive System:
A RePast Simulation of the Anti-Viral Immune Response.
http://cscs.umich.edu/swarmfest04/Program/Abstracts/abstracts.html#FolcikV
Virginia A. Folcik and Charles G. Orosz. 2006. An Agent-Based Model Demonstrates that the Immune
System Behaves Like a Complex System and a Scale-Free Network.
http://www.nd.edu/~swarm06/Schedule/schedule.html
Virginia A. Folcik, Gerard Nuovo, Samir N. Ghadiali, James N. Allen and Clay B. Marsh. 2009.
Using Agent-Based Modeling to Study Interstitial Lung Disease.
http://www.swarm.org/index.php/Using_Agent-Based_Modeling_to_Study_Interstitial_Lung_Disease
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