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Patrick Nana-Sinkam, MD
Assistant Profesor
Research Director, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
201 Davis Heart and Lung Research Institute
473 West 12th Avenue
Columbus, OH 43210
Phone: (614) 247-7707
Clinical Interests
Thoracic malignancies
Smoking related lung disease
Critical care
Research Interests
Focus/Project 1: One goal of our laboratory is to elucidate the role of recently discovered microRNAs in lung tumor development and progression. We are approaching this through analysis in primary human lung cancers and peripheral blood complemented by allied studies that examine the effects of selective microRNA targeting on cancer cell phenotype.
Focus/Project 2: Our laboratory has been very interested in increasing our understanding of the molecular heterogeneity that exist in lung cancer by utilizing genomic and proteomic platforms coupled with computational modeling. By applying systems biology to human samples, we may identify perturbations of key biological networks that are critical to tumor development and progression.
Focus/Project 3: Another area of interest is examining the role of prostaglandins on endothelial survival in tobacco related lung disease. We recently made the observations that components of the cyclo-oxygenase pathway have either protective or detrimental effects on the pulmonary vasculature in diseases such as chronic obstructive pulmonary disease and lung cancer. We are using a murine model of lung specific prostacyclin over-expression with both short and long term cigarette smoke exposure to examine the mechanisms by which this molecule may confer protection to the pulmonary vasculature and epithelium.
Recent Publications
Stearman, R.S., Grady,M., Nana-Sinkam, P., Garcia,M., Geraci, M.W., Multifacted regulation of human prostacyclin synthase promoter in lung cancer cell lines, Mol Cancer Res, 2007, Mar; 5 (3): 295-308.
Nana-Sinkam SP, Lee, JD, Sotto-Santiago,S., Stearman, RS.,Choudhery, Q., Voelkel,N.F. and Geraci,MW, Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke , Am J Respir Crit Care Med, 2007, Apr 1;175(7):676-85.
Bull, T.M., Meadows, C.A., Coldren, C.D., Moore, M., Sotto-Santiago, S.M., Nana-Sinkam, S.P., Campbell, T.B., Geraci, M.W., Human Herpesvirus-8 infection of primary pulmonary microvascular endothelial cells, Am J Respir Cell Mol Biol, 2008 Dec; 39 (6): 706-16. Epub 2008 Jun 27
MicroRNA-126 inhibits invasion in non-small cell lung cancer cell lines Crawford,M., Brawner E., Batte, K., Yu, L., Hunter, M., Otterson, G. Nuovo, G.J. Marsh, C.B and Nana-Sinkam, S.P. , Biochem Biophys Res Commun, 2008, Sep 5; 373 (4): 607-612. Epub 2008 July 3.
Nana-Sinkam, S.P., Hunter, M.G., Nuovo, G.J., Schmittgen, T.D., Gelinas, R., Galas, D., Marsh, C.B., Integrating the microRNome into the study of lung disease, Am J Respir Crit Care Med, 2009; 179 (1): 4-10 Epub 2008 Sep 11
Hunter, M.G., Ismail, N., Zhang, X., Aguda, B.D., Lee, E.J., Yu, L., Xiao,T., Schafer, J.,Lee, M., Schmittgen, T.D., Nana-Sinkam, S.P., Jarjoura, D., Marsh, C.B., Identification and characterization of miRNA expression in human peripheral blood microvesicles, PLOS ONE, 2008; 3 (11): e 3694. Epub 2008 Nov 11.
Nouvo, G.J., Elton,T.S., Nana-Sinkam, P., Volinia,S., Croce,C.M., Schmittgen,T.D., A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with putative miR targets, Nature protocols, Epub January 8, 2009
Wu, X., Hunter, M.G., Crawford, M., Nuovo, G.J., Marsh, C.B., Otterson, G.A., Nana-Sinkam, S.P., MicroRNAs in the pathogenesis of lung cancer, Journal Of Thoracic Oncology, 2009 (epub ahead of print May 28, 2009)
Crawford, M., Batte, K., Yu, L., Wu, X., Nuovo,G.J.,Marsh, C.B.,Otterson, G.A., Nana-Sinkam, S.P., MicroRNA 133B targets pro-survival molecules BCL-W and MCL-1 in lung cancer, Biochem Biophys Res Commun, October 23, 2009
Nana-Sinkam, S.P., Karsies, T., Riscilli, Ezzie, M.E., Piper-Hunter, M., Lung microRNAs from development to disease
Expert Review of Respiratory Medicine, 2009 (accepted) Duan W, Gao L, Wu X, Wang L, Nana-Sinkam P, Otterson GA, Villalona-Calero MA. MicroRNA-34a is an important component of PRIMA-1 induced apoptotic network in human lung cancer cells. International Journal of Cancer, accepted 2009 NetWellness Dr. Nana-Sinkam is a NetWellness expert in lung cancer. NetWellness is an unbiased, non-profit consumer health information service delivered on the Web through the collaborative efforts of the University of Cincinnati, The Ohio State University, and Case Western Reserve University. Since 1995, NetWellness’ mission has been to provide the highest quality health information and education to meet the growing trend of the public to use the Internet for medical and health information. Health care professionals, including physicians, nurses, dietitians, pharmacists, dentists, genetic counselors, optometrists, psychologists, psychiatrists, physical therapists, speech and hearing therapists, occupational therapists, athletic trainers, and social workers answer consumer questions and provide current health information.
Click here for information on the The Ohio State University Pulmonary Oncology Clinic Curriculum.
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