Name:

Courtney Nicholas

Education:

B.S.    Biology, The University of Scranton, Scranton PA

Mentor:

Andrea Doseff, PhD

Research Interests:

I am currently interested in studying the subcellular localization of the caspase-3 protein, as well as two other proteins which are potential regulators of caspase-3 activity.  I will be investigating the localization of these proteins under normal as well as apoptotic conditions in human monocytes and macrophages.

Awards and Honors:

The Parviz Lalezari Award for Research Excellence

Young Investigator’s Symposium, Montefiore Medical Center

May 2, 2003.  First Place.

Publications:

Inactivation of p21^(WAF1/cip1) enhances intestinal tumor formation in Muc2 -/- mice.  Yang, et al.  American Journal of Pathology.  2005 Apr.

Gene Expression Profiling of Intestinal Epithelial Cell Maturation along the Crypt-Villus Axis.  Mariadason, et al.  Gastroenterology.  2005 Apr.

Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells.
Arango, et al.  British Journal of Cancer. 2004 Nov.

Gene Expression Profiling Based Prediction of Response of Colon Carcinoma Cells to 5-Fluoro-Uracil and Camptothecin.  Mariadason, et al.  Cancer Research, 2003 December.

Targeted Inactivation of p27^kip1 is Sufficient for Large and Small Intestinal Tumorigenesis in the Mouse, which can be Augmented by a Western-Style High-Risk Diet.  Yang, et al.  Cancer Research.  2003 August.

c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis.  Arango, et al.  British Journal of Cancer 2003.

Colorectal cancer in mice genetically deficient in the mucin Muc-2.  Velcich, et al. Science. 2002.

p21^(WAF1/cip1) Is an Important Determinant of Intestinal Cell Response to Sulindac in vitro and in vivo.  Yang, et al. Cancer Research. 2001 August.