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Estelle Cormet-Boyaka, PhD
Assistant Professor
201 Davis Heart and Lung Research Institute
473 West 12th Avenue
Columbus, OH 43210
Phone: (614) 247-7707
Specialty Interests
Membrane transport
Epithelial biology
Protein-protein interaction
Research Interests
Biology of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR), a chloride channel implicated in Cystic Fibrosis and secretory diarrhea, Dysregulation of CFTR by pollutants and lung inflammation
Publications
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Estelle Cormet-Boyaka, Jeong S. Hong, Bakhram K. Berdiev, James A. Fortenberry, Jessica Rennolds, JP Clancy, Dale J. Benos, Prosper N. Boyaka, and Eric J. Sorscher. (2009) A Truncated CFTR Protein Rescues Endogenous Delta508-CFTR and Corrects Chloride Transport in Mice. FASEB J, In press.
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Rennolds J, Boyaka PN, Bellis SL, and Cormet-Boyaka E. Low temperature induces the delivery of mature and immature CFTR to the plasma membrane. Biochem. Biophys. Res. Commun. 366(4):1025-9 (2008).
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Rennolds J, Tower C, Musgrove L, Fan L, Maloney K, Clancy JP, Kirk KL, Sztul E, and Cormet-Boyaka E. CFTR trafficking is mediated by the COPI coat in epithelial cells. J. Biol. Chem. 283(2):833-9 (2008).
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P.N. Boyaka, A. Duverger, E. Cormet-Boyaka, and J.-N. Tournier. Mucosal Immunity Against Anthrax. Chapter in Book: Immunity Against Mucosal Pathogens. Editor: Michael Vajdy Publisher: Research Signpost (In press) 2008.
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M. L. Styers, R. Grabski, E. Cormet-Boyaka, and E. Sztul. Depletion of ß-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of Caveolin-1. Am. J. Physiol.: Cell Physiology (2008).
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Berdiev BK, Cormet-Boyaka E, Tousson A, Qadri YJ, Oosterveld-Hut HMJ, Hong JS, Gonzales PA, Fuller CM, Sorscher EJ, Lukacs GL, and Benos DJ. Molecular Proximity of CFTR and ENaC Assessed by Fluorescence Resonance Energy Transfer. J. Biol. Chem. 282(50):36481-8 (2007).Su X.-F., Q. Li, K. Shrestha, E. Cormet-Boyaka, L. Chen, P.R. Smith, E.J. Sorscher, D.J. Benos, S. Matalon, and H.-L. Ji. Inter-regulation of proton-gated Na+ channel 3 and cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 281(48):36960-8 (2006).
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E. Cormet-Boyaka, M. Jablonsky, A.P. Naren, P.L. Jackson, D.D. Muccio, and K.L. Kirk. Rescuing CFTR processing mutants by trans-complementation. Proc. Natl. Acad. Sci. USA 101(21)8221-8226 (2004).
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E. Cormet-Boyaka, A. P. Naren, and K. L. Kirk. CFTR interacting proteins. In: The CFTR chloride channel, ed. Landes, chapter 8 (2003).
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E. Cormet-Boyaka, A. Di, S. Y. Chang, A. P. Naren, A. Tousson, D. J. Nelson, and K. L. Kirk. CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex. Proc. Natl. Acad. Sci. U S A 99(19):12477-82 (2002).
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P.N. Boyaka, M. Marinaro, R.J. Jackson, F.W. van Ginkel, E. Cormet-Boyaka, K.L. Kirk, C.R. Kensil, and J.R. McGhee. Oral QS-21 requires early IL-4 help for induction of mucosal and systemic immunity. J. Immunol. 166(4):2283-90 (2001).
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A.P. Naren, A. Di, E. Cormet-Boyaka, P.N. Boyaka, J.R. McGhee, A. Tousson, W. Zhou, J.F. Engelhardt, D.J. Nelson, and K.L. Kirk. Syntaxin 1A is expressed in native airway epithelial tissues where it tonically inhibits CFTR function. Journal of Clinical Investigation 105(3), 377-386 (2000).
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A. Mordrelle, E. Jullian, C. Costa, E. Cormet-Boyaka, R. Benamouzig, D. Tome, and J.-F. Huneau. EAAT1 is involved in transport of L-glutamate during differentiation of the Caco-2 cell-line. Am. J. Physiol. Gastrointest. Liver Physiol.279(2), G366-G373 (2000).
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A.P. Naren, E. Cormet-Boyaka, J. Fu, M. Villain, J.E. Blalock, M.W. Quick, and K.L. Kirk. CFTR chloride channel regulation by an interdomain interaction. Science 286, 544-548 (1999).
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E. Cormet-Boyaka, J-F Huneau, A. Mordrelle, P.N. Boyaka, C. Carbon, E. Rubinstein, and D. Tome. Secretion of sparfloxacin from the human intestinal Caco-2 cell-line is altered by P-glycoprotein inhibitors. Antimicrobial Agents and Chemotherapy 42(10), 2607-2611 (1998).
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E. Cormet, J-F Huneau, and D. Tome. Sparfloxacin binds to rabbit intestinal brush-border membrane vesicles by ionic interactions. International Journal of Pharmaceutics 159, 127-130 (1997).
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E. Cormet, J-F Huneau, M. Bouras, C. Carbon, E. Rubinstein, and D. Tome. Evidence for a passive diffusion of sparfloxacin through the brush-border membrane of Caco-2 cells. Journal of Pharmaceutical Sciences 86(1), 33-36 (1997).
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E. Cormet, A-M Barlier, J-F Huneau, E. Rubinstein, C. Carbon, R. Farinotti, and D. Tome. Sparfloxacin secretion across Caco-2 cells involves a multidrug resistant-like mechanism. Drugs 49(suppl.2), 307-309 (1995).
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