Name:

Jonathan P. Butchar

Education:

1996     B.S.     Exercise Science, The Ohio State University

1996     M.S.    Exercise Physiology, Southern Illinois University

2006     Ph.D.   Molecular Genetics, The Ohio State University

Mentor:

Susheela Tridandapani, Ph.D.

Research Interests:

Examination of macrophage innate immune response at the genomewide level.

I am currently using short-oligonucleotide microarrays to gain a global understanding of macrophage responses to IgG immune complexes and microbial ligands.

Awards and Honors:
2006-07     Post-doctoral Fellowship- Ruth L. Kirschstein National Research Service Award

Publications:

1. Butchar, J.P., Parsa, K.V.L., Marsh, C.B. and S. Tridandapani . (2006) Negative regulators of Toll-like receptor 4-mediated macrophage inflammatory response. Current Pharmaceutical Design. In Press

2. Sweeney, M.C., Wavereille A-S., Park, J., Butchar, J.P., Tridandapani, S., and D. Pei. (2005) Decoding protein-protein interactions through combinatorial chemistry: Sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains. Biochemistry. 44:14932-47

3. Jacobsen, T.L., Cain, D., Paul, L., Justiniano, S., Alli, A., Mullins, J.S., Wang, C.P., Butchar, J. P. and Simcox, A. (2006) Genetic Analysis of Genes Differentially Expressed in the Drosophila Wing Disc. Genetics. In Press

4. Butchar, J.P., Jacobsen, T.L., Markossian, S. and Simcox, A. (2006) Genomewide Transcriptional Analysis of Drosophila Cell Lines Identifies Genes Involved with Immortalization and Permits Rapid Classification of New Lines. In Preparation.

5. Butchar, J. P., Jacobsen, T., Cain, D., Justiniano, S., Paul, L., Phillips, R., and Simcox, A. (2006) Microarray Analysis Reveals Novel Targets of the Drosophila EGF Receptor and Implicates Sulf1 as a Negative Feedback Regulator. In Preparation.