Name:  Julie Roda, PhD

Education: 
2002    B.S., Biology, Brandeis University
2007    Ph.D., Integrated Biomedical Sciences Graduate Program, Ohio State University

Mentor:  Clay Marsh, M.D.

Research interests:  Role of tumor-associated macrophages in the breast cancer microenvironment

Honors and Awards:

2004    Outstanding Poster Presentation Award, 3rd Annual Ohio State University Medical Center Research Forum
2005    Invited Speaker, Annual Meeting of the International Society for the Biological Therapy of Cancer, Alexandria, Virginia
2006    1st Place Poster Presentation Award, The Ohio State University Comprehensive Cancer Center Annual Scientific Meeting

Grants: 
2004-2006   Susan G. Komen Foundation Breast Cancer Dissertation Award, Role: P.I.
2008           NIH T32, Mechanisms of lung inflammation, P.I.: Mark Wewers, Role: Post-Doctoral Fellow

Publications:

1.  Roda J.M., Parihar R., and W.E. Carson, III.  CpG-containing oligodeoxynucleotides act through TLR9 to enhance the natural killer cell cytokine response to monoclonal antibody-coated tumor cells.  J. Immunol. 175(3):1615-1627, 2005.

2.   Parihar, R., Trotta, R., Roda J.M., Ferketich, A.K., Tridandapani, S., Caligiuri M.A., and W.E. Carson, III.  Src homology 2-containing inositol 5’-phosphatase 1 negatively regulates IFN-g production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12.  Cancer Res.  65(19): 9099-9107, 2005. 

3.  Roda J.M., Parihar R., Magro C., Nuovo G., Tridandapani S., and W.E. Carson, III.  NK cells produce T cell recruiting chemokines in response to antibody-coated tumor cells.  Cancer Res.  66(1):517-524, 2006.

4.  Ganesan L.P., Joshi T., Fang H., Kutala V.K., Roda J.M., Trotta R., Lehman A., Kuppusamy P., Byrd J.C., Carson W.E., Caligiuri M.A., and S. Tridandapani.  Fc(gamma)-induced production of superoxide and proinflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways.  Blood.  108(2):718-25, 2006.  

5. Roda J.M., Parihar R., Mani A., Lehman, A., Tridandapani S., and W.E. Carson, III.  Interleukin-21 enhances natural killer cell activation in response to antibody-coated targets.  J. Immunol. 177(1):120-9, 2006.     

6.  Brown L., Roda J.M., Terrell C., RayChaudhury A., Crespin T., Carson W.E. III, and G.B. Lesinski.  Interferon-alpha and CpG oligodeoxynucleotides elicit additive immune stimulatory and anti-tumor effects.  Surgery.  140(2):297-306, 2006.

7.   Roda J.M., Joshi T., Butchar J.P., McAlees J., Tridandapani S., and W.E. Carson, III.  The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor-positive tumor cells.  Clin Cancer Res.  13(9)6419-24, 2007.

8.  Roda J.M., Kondadasula S.V., Parihar R., Trotta R., Tridandapani S., and W.E. Carson, III.  Co-localization of the IL 12 receptor and Fc?RIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of IFN-?.  Blood. 111(8):4723-30, 2008.

9.  Gowda, A., Roda J.M., Hussain R., Joshi T., Ramanunni A., Kindsvogel W., Tridandapani S., Caligiuri M.A., Carson W.E., Muthusamy N., and John C. Byrd.  IL-21 mediates apoptosis through upregulation of the BH3 family member Bim and enhances both direct and antibody-dependent cellular cytotoxicity in chronic lymphocytic leukemia cells.  Blood. 111(9):4720-30, 2008.