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Jon Von Visger, MD


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395 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-0788

Email: von-visger.1@osu.edu

 

Current OSU Appointments

Assistant Professor-Clinical, Nephrology

Physician, FGP-Nephrology

 

Clinical Interest

Immunopathology, Internal Medicine, Nephrology, Regenerative medicine

Biographical

Since I have an extensive laboratory research background before my clinical carreer, my initial intent when I came to OSU in 2005, was to spend more time doing laboratory research on the traditional tenure track. I have since changed to the clinical track and redirected my efforts toward more translational research, applying my basic science experience toward clinical studies.



I have already completed four multicenter clinical trials as the site principal investigator since coming to OSU, and hope to keep the ball rolling. The two most important areas of transplant renal failure to me remain delayed graft function (DGF; similar to acute kidney injury), and antibody rejection, and I continue to pursue study of these processes with the hope of improving them.

While novel therapies often require novel drugs, sometimes it only requires novel approaches of current therapy. I have recently applied for an IND application for the use of an already FDA approaved drug, Belatacept, in the management of DGF.

I have already attained FDA approval for proceeding with my investigator initiated DGF protocol under my own IND application, and currently await our own institutional IRB application and budgetary approval from Bristol-Myers Squibb to move forward. I find that I am most excited to be applying therapy at the patient level in a translational than staying at the benchside. To date, there has yet been a successful attempt at improving DGF outcomes, and the Belatacept trial has the potential for a landmark study.

In a second, yet to be funded clinical trial, I am working with collaborators across several disciplines to evaluate a novel biological detection process using immunologically modified field-effect transistors. These have the potential to detect picomolar levels of inflammatory citokines that might be used to diagnose rejection in biologic fluids.



Despite dwindling NIH support for research, I have been resourceful enough to have had some reasonable success in bringing and completing clinical/translational studies here at OSU. While industry sponsored studies appear to be the growing trend, I still intend to compete for the limited remaining NIH funds.



My national reputation has been growing slower than anticipated, since completing my fellowship at Mass. General Hospital. However, I am recognized within my field and have continued to develop National exposure through presenations and multicenter trial participation that garner important resources for future development. As one of the largest national kidney transplant centers, OSU has the potential to provide significant resources for career development, in both patient volume for clinical experience as well as data collection for clinical trials. This is why I came to OSU.

Academic Advising

2012 - present anthony alvarado The Ohio State University. Graduated 2013.
2007 - 2008 Fawn Langerman The Ohio State University. Graduated 2008.
 

Books

Von Visger, Jon. Studies Relating to Neural Regeneration: 1. A Neurite-Promoting Factor Derived From Striated Muscle, and 2. Differentiation of Progenitor Cells for Newborn Rat Forebrain.. Baltimore, MD, US|USA: University Microfilms Inc, January 1996.

 

Certifications

1999 - present MD: American Board of Internal Medicine
2004 - present MD: American Board of Internal Medicine
2005 - present MD: State Medical Board of Ohio
 

Clinical Services

06/01/2005 Attending, Assistant Professor (clinical) (The Ohio State University)

Degrees

1986 B.S., UCLA Los Angeles California

1988 M.S., UCLA Los Angeles California

1996 M.D./Ph.D., University of Maryland

 

Editorial Activities

2006 - present arthritis and rheumatism
2008 - present clinical nephrology
2010 - present Transplantation
2012 - present Ibnosina
 

Honors

2010 - 2012 Certificate of Excellence in Patient Service. The Ohio State Unviversity Wexner Medical Center.
 

Journal Articles

Arakawa, T., J. Von Visger, M. McGinley, M.F. Rohde, G.M.Fox, and L.O. Narhi. "Alteration in Folding Efficiency andConformation of Recombinant Human Tumor Necrosis Factor-alpha by Replacing Cysteines 69 and 101 with Aspartic Acid 69 and Arginine 101." Protein Engineering. Vol. 8, no. 3. (January 1990.): 721-724.

VONVISGER,J,R; Yeon,D,S; Oh,T,H; Markelonis,G,J. "DIFFERENTIATION AND MATURATION OF ASTROCYTES DERIVED FROM NEUROEPITHELIAL PROGENITOR CELLS IN CULTURE." EXPERIMENTAL NEUROLOGY. Vol. 128, no. 1. (July 1994.): 34-40.

Francis,J,W; VONVISGER,J; Markelonis,G,J; Oh,T,H. "NEUROGLIAL RESPONSES TO THE DOPAMINERGIC NEUROTOXICANT 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE IN MOUSE STRIATUM." NEUROTOXICOLOGY AND TERATOLOGY. Vol. 17, no. 1. (January 1995.): 7-12.

Oh,T,H; Markelonis,G,J; VONVISGER,J,R; BAIK,B; Shipley,M,T. "ACIDIC PH RAPIDLY INCREASES IMMUNOREACTIVITY OF GLIAL FIBRILLARY ACIDIC PROTEIN IN CULTURED ASTROCYTES." GLIA. Vol. 13, no. 4. (April 1995.): 319-322.

Von Visger, Jon; Magee, Colm. "Low molecular weight heparins in renal failure.." Journal of nephrology. Vol. 16, no. 6. (January 2003.): 914-6.

Breimer ME, L Rydberg, A Jackson, D Lucas, A Zachary, J Melancon, J Von Visger, R Pelletier, S Saidman, W Williams,Jr., J Holgersson, G Tyden, G Klintmalm, S Coultrup, S Sumitran-Holgersson, and P Grufman. "Multicenter Evaluation of a Novel Endothelial Cell Crossmatch Test in Kidney Transplantation." Transplantation. Vol. 27, no. 87 (4). (January 2008.): 549-556.

Moffat-Bruce, S., T. Pesavento J. Von Visger, D. Nunley, A. Pope-Harman, S. Martin, P. Ross. "Successful Management of ImmunoSuppression in a Patient with Sever Hyperammonemia After Lung Transplantation." J. Heart and Lung Transplant. Vol. 27, no. 7. (July 2008.): 801-803.

Nori,Uday,S; Agarwal,Anil,K; Von Visger,Jon,R. "Dietary Therapy in Hypertension." NEW ENGLAND JOURNAL OF MEDICINE. Vol. 363, no. 16. (October 2010.): 1580-1581.

Humes HD, Sobota JT, Ding F, Song JH and the RAD Study Group. "A Selective Cytopheretic Inhibitory Device to Treat the Immunological Dysregulation of Acute and Chronic Renal Failure." Blood Purif. Vol. 1, no. 29 (2). (January 2010.): 183-190.

Ware,Kyle; Brodsky,Polina; Satoskar,Anjali,A; Nadasdy,Tibor; Nadasdy,Gyongyi; Wu,Haifeng; Rovin,Brad,H; Bhatt,Udayan; Von Visger,Jon; Hebert,Lee,A; Brodsky,Sergey,V. "Warfarin-Related Nephropathy Modeled by Nephron Reduction and Excessive Anticoagulation." JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 22, no. 10. (October 2011.): 1856-1862.

Albawardi,Alia; Satoskar,Anjali; Von Visger,Jon; Brodsky,Sergey; Nadasdy,Gyongyi; Nadasdy,Tibor. "Proliferative Glomerulonephritis With Monoclonal IgG Deposits Recurs or May Develop De Novo in Kidney Allografts." AMERICAN JOURNAL OF KIDNEY DISEASES. Vol. 58, no. 2. (August 2011.): 276-281.

Singh,Neeraj; Parikh,Samir; Bhatt,Udayan; VonVisger,Jon; Nori,Uday; Hasan,Ayesha; Samavedi,Srinivas; Andreoni,Kenneth; Henry,Mitchell; Pelletier,Ronald; Rajab,Amer; Elkhammas,Elmahdi; Pesavento,Todd. "Cardiac Stress Test as a Risk-Stratification Tool for Posttransplant Cardiac Outcomes in Diabetic Kidney Transplant Recipients." TRANSPLANTATION. Vol. 94, no. 12. (December 2012.): 1224-1229.

Roth,Rachel; Parikh,Samir; Makey,Dayanand; Foster,Jamison; Rozenblit,Grigory; Satoskar,Anjali; Nadasdy,Gyongyi; Von Visger,Jon; Hebert,Lee; Rovin,Brad,H; Nadasdy,Tibor; Brodsky,Sergey,V. "When Size Matters: Diagnostic Value of Kidney Biopsy according to the Gauge of the Biopsy Needle." AMERICAN JOURNAL OF NEPHROLOGY. Vol. 37, no. 3. (January 2013.): 249-254.

Parikh,Samir; Nagaraja,Haikady; Agarwal,Anil; Samavedi,Srinivas; Von Visger,Jon; Nori,Uday; Andreoni,Kenneth; Pesavento,Todd; Singh,Neeraj. "Impact of post-kidney transplant parathyroidectomy on allograft function." CLINICAL TRANSPLANTATION. Vol. 27, no. 3. (May 2013.): 397-402.

 

Reference Works

January 1986 Ruettinger, R T., J. Von Visger, A.J. Fulco."Relative Induction of Three Distinct Cytochrome P-450 Species in Twelve Strains of Bacillus Megaterium" philadelphia.
January 1993 Von Visger, J., T.H. Oh, D.S. Yeon, G.J. Markelonis."Maturation of CNS Stem Cells from New Born Rat Forebrain in a Defined Medium" New york.
January 1995 Oh, T H; G. Markelonis, J. Von Visger, B. Baik, M.T. Shipley, M T."Acidic pH Increases Immunoreactivity of GFAP in Cultured Rat Astrocytes" philadelphia.
June 2005 Linde, P., J. Von Visger, K. Maxwell, J. Brotherton, C. Conlin, A.B. Cosimi, W.W. Williams."Enhancing In Vitro Clearance of Small Molecule Toxins Using a Novel CVVH-Based Recirculation Loop: Implicationsfor Bioartificial Liver Support Systems and Renal Replacement Therapies" philadelphia.
January 2006 Pesavento, T., E. Davies, J. Von Visger, U. Nori, B. Miller, R.M. Ferguson."Randomized, Prospective Prednisone Withdrawl Trial in Kidney Transplant Patients Treated with Mycophenolate Sodium Comparing Rapamycin vs C2 Dosed Cyclosporine" philadelphia.
October 2007 Dipaola, N., J. Von Visger, P. Adams."Acute Humoral Rejection Mediated By Donor Specific Anti-Endothelial Antibodies Detected Using XM-One" New York.
May 2007 Pesavento T., U. Nori, J. Von Visger, M. Henry, R. Ferguson."Sirolimus, Independent Of Cyclosporine, Is Associated With Worsened Proteinuria In Renal Transplantation" malden.
May 2008 Nori, U.S., T. Pesavento, E. Davies, J. Von Visger, B. Miller, R. M. Ferguson."Randomized Prospective Prednisone Withdrawl Trial In kidney Transplant Patients Treated with Sirolimus vs. Microemulsified Cyclosporine Based Regimens" Malden.
August 2008 Zachary, A. A Jackson, J. Melancon, M. Breimer, L. Ryderberg, J. Von Visger, R. Pelletier, S. Saidman, W.W. Williams, G. Klintmalm, S. Coultrup, J. Holgersson, G. Tyden, S. Holgersson, P. Grufman."Final Clinical Trial Data Evaluating The XM-One Endothelial Crossmatch Test In Predicting Early Rejection Episodes in Renal Allograft Recipients." Malden.
January 2009 Humes H D, Dillon J, Tolwani AJ, Cremisi H, Wali R, Murray P, Ye J, Chawla LS, Vijayan A, Finkel, KW Kraus,M, Atta M, Von Visger J, Block GA, Charytan D, and Vinnikova AK."A Novel Selective Cytopheretic Inhibitory Device (SCD) Improves Mortality in ICU Patients With Acute Kidney Injury (AKI) and Multiorgan Failure (MOF) In a Phase II Clinical Study" Unionville, CT.
April 2010 Parikh, S, Gunay, Y, Srinivas, S, Shah, R, Von Visger, J, Nori, U, Rajab, A, Pesavento, T, Sing."Cardiac Stress Test as a Risk Stratification Tool for Early Post Kidney Transplant Cardiovascular Outcomes in Diabetic ESRD Patients" Malden. : 306
April 2012 Alvarado, A, Casal, P, Theiss, A, Wang, Y, Hadley, G, Singh, N, Brillson, L, Pelletier, R, Lu, W, Lee, S, and Von Visger, J."Monitoring of Transplant Graft Status by Immunologically Modified Field Effect Transistors" columbus.
May 2012 Wier, M, Vincenti, F, Von Visger, J, Kopyt, N, Mannon, R, Tseng, S, Goodman, W, and Wolf, M.."Evolution of Persistent Hyperparathyroidism in Kidney Transplant Recipients: A Propspective Cohort Study" Malden.
May 2012 Vincenti, F, Weir, Von Visger, J, et al."A Prospective Cohort Study of Persistent Hyperparathyroidism in Kidney Transplant Recipients" Unionville. : 8
May 2012 Andreoni, K, Elkhammas, E, Rajab, A, Pelletier, R, Bumgardner, G, Forbes, R, Singh, N, Von Visger, J, Pesavento, T, Davies, E, Nori, U, Henry, M."Influence of BMI and Age on Simultaneous Kidney-Pancreas Recipients" malden.
May 2012 Nori, U, Shah, R, Haddad, N, Von Visger, J, Agarwal, A."Management of Renal Transplant Recipients with Failing Alolgrafts and Transitioning to Renal Replacement Therapy" Malden. : 493
April 2013 Pelletier, R, Von Visger, J, Adams, P, and Henry, M."The Outcome of Luminex Single Antigen Bead DSA Detection in Post-Transplant Alloantibody Producing Recipients Does Not Correlate with Differential Graft Loss" Malden. : 418

Inventions and Patents

Jon Von Visger, Amin Arnaout, Peter Linde, Alejandro Morales. "Kidney Precursor Stem Cells Flk1+, Sca-1+." Massachusetts Technology Transfer Center, Harvard. Filed January 2006.

 

Presentations

"Prolonged Early Graft Dysfunction with Sirolimus and Association with Mortality in Renal Transplant Recipients." Presented at American Transplant Congress, San Francisco, CA, US|USA. (May 2007)

"A New Endothelial Progenitor Cell Flow-Based Method for Donr Recipient Cross-Matching Detects Donor-Specific Endothelial Antigens." Presented at American Transplant Congress, San Francisco, CA, US|USA. (May 2007)

"Review of 90,866 Renal Transplants: Survival Imact of Sirolimus." Presented at American Transplant Congress, Toronto, CA|CAN. (May 2008)

"RECURRENCE OF IGA NEPHROPATHY POST KIDNEY TRANSPLANTATION IN STEROID FREE VS. STEROID DEPENDENT IMMUNOSUPPRESSION PROTOCOL." Presented at American Transplant Congress, San Diego, CA, US|USA. (May 2010)

"Response to Therapy and Predictors of Graft Survival in Antibody Mediated Rejection." Presented at American Transplant Congress, Boston, MA, US|USA. (June 2012)

"Tolerance of Ace-Inhibitor/ARB Use Post Renal Transplant." Presented at American Transplant Congress, Seattle, WA, US|USA. (May 2013)

"Immunologically Modified FETs for Protein Detection in Biologic Fluids." Presented at American Transplant Congress, seattle, WA, US|USA. (May 2013)

"Examination of Infectious Complications with Plasmapheresis in Combination with Anti-Thymocyte Globulin for the Treatment of Acute Rejection." Presented at American Transplant Congress, Seattle, WY, US|USA. (May 2013)

 

Professional Activities

present volunteer. Upper Arlington School systems. upper arlington, OH.
present consultant. AmGen. Thousand Oaks, CA.
2006 - present volunteer kidney screening. National Kidney Foundation. Columbus, OH.
2011 - present Judge volunteer. The Ohio State University. Columbus, OH.
2013 volunteer. Denman Forum. Columbus, OH.
 

Unpublished Works

von visger, J, Gunay, Y, andreoni, K et al.. The Risk of Recurrent IgA Nephropathy in a Steroid-Free Protocol and Other Modifying Immunosuppression. December 2013.