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Stephanie Seveau, PhD


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484 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-7671

Email: seveau.1@osu.edu

 

Current OSU Appointments

Associate Professor, Microbiology Admin

Assistant Professor, SBS-Microbial Infectn/Immunity

 

Academic Advising

2008 - present Tracy Keiser The Ohio State University.
2008 - present Tracy Keiser The Ohio State University.
2008 - present Stephen Vadia The Ohio State University.
2008 - present Stephen Vadia The Ohio State University. Role of listeriolysin O in host cell invasion by Listeria monocytogenes
2010 - present Bin Ni The Ohio State University.
2010 - present Bin Ni The Ohio State University.
2011 - present Gayathri Natarajan The Ohio State University.
2011 - present Gayathri Natarajan The Ohio State University.
2013 - present Eric Weber The Ohio State University.
2013 - present Singh Jasneet The Ohio State University.
2006 - 2007 Peter El-Dahdah The Ohio State University. Graduated 2007.
2007 Andrew Schneider The Ohio State University. Graduated 2007.
2007 Andrew Bruggeman The Ohio State University. Graduated 2008. Generation of fluorescent recombinant listeriolysin O toxin
2007 Bachir Paraag The Ohio State University. Graduated 2007.
2007 - 2008 Andrew Bruggeman The Ohio State University. Graduated 2008. Generation of fluorescent recombinant listeriolysin O toxin
2007 - 2008 Katerine Daprile The Ohio State University. Graduated 2008.
2008 Michelle Elaine The Ohio State University.
2008 Timothey Baker The Ohio State University. Graduated 2008.
2008 - 2009 Siwen Dong The Ohio State University. Graduated 2010.
2007 - 2011 Dennis Horvath The Ohio State University. Graduated 2011.
2007 - 2011 Dennis Horvath The Ohio State University. Graduated 2011.
2007 - 2011 Dennis Horvath The Ohio State University. Graduated 2008.
2007 - 2011 Hannah Cummings The Ohio State University. Graduated 2009.
2007 - 2011 Hannah Cummings The Ohio State University. Graduated 2011.
2010 - 2011 Victoria Masson The Ohio State University. Graduated 2011.
2010 - 2011 Alexender Coe The Ohio State University.
2011 Danielle Chapell The Ohio State University.
2007 - 2012 Eric Holbrook The Ohio State University. Graduated 2012.
2007 - 2012 Kiley E. The Ohio State University. Graduated 2009.
2007 - 2012 Eric Holbrook The Ohio State University. Graduated 2012.
2007 - 2012 Kiley Dare The Ohio State University. Graduated 2012.
2010 - 2012 Colleen Nackerman The Ohio State University. Graduated 2012. Anti-Listeria monocytogenes activity of neutrophils
2010 - 2012 Colleen Nackerman The Ohio State University. Graduated 2012. Anti-Listeria monocytogenes activity of neutrophils
2012 Victoria Liang The Ohio State University.
2012 Brittany Pollard The Ohio State University.
2008 - 2013 Geoffrey Gonzales The Ohio State University. Graduated 2013.
2008 - 2013 Geoffrey Gonzales The Ohio State University. Graduated 2013.
2008 - 2013 Eusondia Arnett The Ohio State University. Graduated 2013. Neutrophil products inhibit LLO secretion and activity, and Listeria monocytogenes intracellular growth
2008 - 2013 Eusondia Arnett The Ohio State University. Graduated 2013.
 

Editorial Activities

2012 - present title
 

Honors

1994 - 1997 Graduate Program, CIFRE. Association National de la Recherche Technique, Paris, France.
1995 Graduate Scholarship. EMBO.
1996 Graduate Scholarship. EMBO.
1997 - present Thesis obtained with the grade "very worthy, with congratulations". PARIS VI.
1998 - 1999 Postdoctoral fellowship. Association pour la Recherche contre le Cancer (ARC), France.
2001 Bourse Roux. Foundation Roux.
2002 - present EMBO classes. Institut Pasteur.
2002 - 2004 Postdoctoral fellowship. Institute Pasteur, Paris, France.
 

Journal Articles

Seveau,S; Lopez,S; Lesavre,P; Guichard,J; Cramer,E,M; HALBWACHSMECARELLI,L. "Leukosialin (CD43, sialophorin) redistribution in uropods of polarized neutrophils is induced by CD43 cross-linking by antibodies, by colchicine or by chemotactic peptides." JOURNAL OF CELL SCIENCE. Vol. 110, (July 1997.): 1465-1475.

Lopez,S; Seveau,S; Lesavre,P; Robinson,M,K; Halbwachs-Mecarelli,L. "CD43 (sialophorin, leukosialin) shedding is an initial event during neutrophil migration, which could be closely related to the spreading of adherent cells." CELL ADHESION AND COMMUNICATION. Vol. 5, no. 2. (January 1998.): 151-160.

Seveau S, Kelle H, Maxfield FR, Halbwachs-Mecarelli l. "Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule." BLOOD. Vol. 95, no. 8. (April 2000.): 2462-70.

Seveau,S; Eddy,R,J; Maxfield,F,R; Pierini,L,M. "Cytoskeleton-dependent membrane domain segregation during neutrophil polarization." MOLECULAR BIOLOGY OF THE CELL. Vol. 12, no. 11. (November 2001.): 3550-3562.

Pierini,L,M; Eddy,R,J; Fuortes,M; Seveau,S; Casulo,C; Maxfield,F,R. "Membrane lipid organization is critical for human neutrophil polarization." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 278, no. 12. (March 2003.): 10831-10841.

Zadeh,A,D; Seveau,S; Halbwachs-Mecarelli,L; Keller,H,U. "Chemotactically-induced redistribution of CD43 as related to polarity and locomotion of human polymorphonuclear leucocytes." BIOLOGY OF THE CELL. Vol. 95, no. 5. (July 2003.): 265-273.

Nusbaum,P; Laine,C; Seveau,S; Lesavre,P; Halbwachs-Mecarelli,L. "Early membrane events in polymorphonuclear cell (PMN) apoptosis: membrane blebbing and vesicle release, CD43 and CD16 down-regulation and phosphatidylserine externalization." BIOCHEMICAL SOCIETY TRANSACTIONS. Vol. 32, (June 2004.): 477-479.

Seveau,S; Bierne,H; Giroux,S; Prevost,M,C; Cossart,P. "Role of lipid rafts in E-cadherin- and HGF-R/met-mediated entry of Listeria monocytogenes into host cells." JOURNAL OF CELL BIOLOGY. Vol. 166, no. 5. (August 2004.): 743-753.

Nusbaum,P; Laine,C; Bouaouina,M; Seveau,S; Cramer,E,M; Masse,J,M; Lesavre,P; Halbwachs-Mecarelli,L. "Distinct signaling pathways are involved in leukosialin (CD43) down-regulation, membrane blebbing, and phospholipid scambling during neutrophil apoptosis." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 280, no. 7. (February 2005.): 5843-5853.

Martinez,J,J; Seveau,S; Veiga,E; Matsuyama,S; Cossart,P. "Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii." CELL. Vol. 123, no. 6. (December 2005.): 1013-1023.

Diakonova,Maria; Heifer,Emmanuele; Seveau,Stephanie; Swanson,Joel,A; Kocks,Christine; Rui,Liangyou; Carlier,Marie-France; Carter-Su,Christin. "Adapter protein SH2-B beta stimulates actin-based motility of Listera monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion." INFECTION AND IMMUNITY. Vol. 75, no. 7. (July 2007.): 3581-3593.

Seveau,Stephanie; Pizarro-Cerda,Javier; Cossart,Pascale. "Molecular mechanisms exploited by Listeria monocytogenes during host cell invasion." MICROBES AND INFECTION. Vol. 9, no. 10. (August 2007.): 1167-1175.

Seveau,Stephanie; Tham,To,N; Payrastre,Bernard; Hoppe,Adam,D; Swanson,Joel,A; Cossart,Pascale. "A FRET analysis to unravel the role of cholesterol in Rac1 and PI 3-kinase activation in the InIB/Met signalling pathway." CELLULAR MICROBIOLOGY. Vol. 9, no. 3. (March 2007.): 790-803.

Hamon,Melanie,Anne; Batsche,Eric; Regnault,Beatrice; Tham,To,Nam; Seveau,Stephanie; Muchardt,Christian; Cossart,Pascale. "Histone modifications induced by a family of bacterial toxins." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 104, no. 33. (August 2007.): 13467-13472.

Hoppe,Adam,D; Seveau,Stephanie; Swanson,Joel,A. "Live cell fluorescence microscopy to study microbial pathogenesis." CELLULAR MICROBIOLOGY. Vol. 11, no. 4. (April 2009.): 540-550.

Haghighat,Anne-Cecile; Seveau,Stephanie. "Quantification of host-microbe interactions by automated fluorescence microscopy." JOURNAL OF IMMUNOLOGICAL METHODS. Vol. 352, no. 1-2. (January 2010.): 186-191.

Arnett,Eusondia; Seveau,Stéphanie. "The multifaceted activities of mammalian defensins.." Current pharmaceutical design. Vol. 17, no. 38. (December 2011.): 4254-4269.

Arnett,Eusondia; Lehrer,Robert,I; Pratikhya,Pratikhya; Lu,Wuyuan; Seveau,Stephanie. "Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes." CELLULAR MICROBIOLOGY. Vol. 13, no. 4. (April 2011.): 635-651.

Vadia,Stephen; Arnett,Eusondia; Haghighat,Anne-Cecile; Wilson-Kubalek,Elisabeth,M; Tweten,Rodney,K; Seveau,Stephanie. "The Pore-Forming Toxin Listeriolysin O Mediates a Novel Entry Pathway of L. monocytogenes into Human Hepatocytes." PLOS PATHOGENS. Vol. 7, no. 11. (November 2011.): e1002356-.

Cummings,Hannah,E; Barbi,Joseph; Reville,Patrick; Oghumu,Steve; Zorko,Nicholas; Sarkar,Anasuya; Keiser,Tracy,L; Lu,Bao; Rueckle,Thomas; Varikuti,Sanjay; Lezama-Davila,Claudio; Wewers,Mark,D; Whitacre,Caroline; Radzioch,Danuta; Rommel,Christian; Seveau,Stephanie; Satoskar,Abhay,R. "Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 109, no. 4. (January 2012.): 1251-1256.

Rogers,Theresa,E; Ataide,Sandro,F; Dare,Kiley; Katz,Assaf; Seveau,Stephanie; Roy,Herve; Ibba,Michael. "A Pseudo-tRNA Modulates Antibiotic Resistance in Bacillus cereus." PLOS ONE. Vol. 7, no. 7. (July 2012.): e41248-.

Habyarimana F, Swearingen MC, Young GM, Seveau S, and BMM Ahmer. "Yersinia enterocolitica inhibits Salmonella enterica and Listeria monocytogenes cellular uptake." Infection and Immunity. Vol. 0, (October 2013.): 10-.

Arnett E, Vadia S, Nackerman CC, Oghumu S, Satoskar AR, McLeish KR, Silvia M. Uriarte ¶, and S Seveau. "Listeriolysin O is degraded by the neutrophil metalloprotease MMP-8 and is unable to mediate Listeria monocytogenes intracellular survival in neutrophils." Journal of Immunology. Vol. 1, (December 2013.): 1-.

 

Reference Works

January 1996 Seveau, S.; Lesavre, P.; Halbwachs-Mecarelli, L.."Neutrophil CD43 (leukosialin, sialophorin) membrane redistribution and association to the cytoskeleton induced by anti-CD43 mab" . : A33
January 1996 Seveau S.; Lopez S.; Lesavre P.; Halbwachs-Mecarelli L.."Surface redistribution of leukosialin (CD43), as well as of CD44 and CD11b, on neutrophils polarized by colchicine" .
January 1998 Seveau, S.; Keller, H.; Halbwachs-Mecarelli, L.."Membrane redistribution of the anti-adhesive molecule CD43 (leukosialin, sialophorin) is correlated with neutrophil polarization and locomotion" . : 333
January 1998 Seveau S.; Keller H.; Piller F.; Halbwachs-Mecarelli L."Membrane redistribution of the anti-adhesive molecule CD43 (leukosialin, sialophorin) is correlated with polarization and locomotion" .
January 1999 Seveau S.; Keller H.; Halbwachs-Mecarelli L.."Membrane redistribution of leukosialin (CD43) in neutrophil uropod is related to cell polarization and motility" .
January 2000 Pierini, L. M.; Fuortes, M.; Seveau, S.; Casulo, C.; Maxfield, F.R.."Membrane cholesterol is critical for asymmetric Rac targeting during human neutrophil migration" . : supplement 565a
January 2000 Seveau, S.; Pierini, L.M.; Maxfield, F.R.."Identification of large-scale asymmetric membrane domains in polarized neutrophils" . : 168
January 2000 Seveau, S.; Maxfield, F.R.; Pierini, L.M.."Asymmetrical distribution and cytoskeletal association of membrane domains in migrating neutrophils" . : supplement 565a
January 2001 Pierini, L.M.; Seveau, S.; Eddy, R.; Maxfield, F. R.."Endocytic recycling kinetics in human neutrophils" . : 3550
January 2004 Seveau, S.; Bierne, H.; Giroux, S.; Prevost, M.; Cossart, P.."Role of lipid rafts in Listeria monocytogenes entry into mammalian cells" . : 123A

Presentations

"Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes." Presented at The American Society for Microbiology, Annual meeting, San Francisco, CA, US|USA. (June 2011)

"A novel mechanism exploited by Listeria monocytogenes to gain entry into non-phagocytic cells." Presented at 18th Midwest Microbial Pathogenesis Conference, Columbus, OH, US|USA. (August 2013)