Mark E. Drew, PhD
1020 BRT
460 W. 12th Ave.
Columbus, OH 43210
Phone: (614) 247-5337
Email: mark.drew@osumc.edu
Current OSU Appointment
Assistant Professor, SBS-Microbial Infectn/Immunity
Chapters In Books
James C. Morris, Zefeng Wang, Shawn A. Motyka, Mark E. Drew, Paul T. Englund. 2004. An RNAi-based genomic library for forward genetics in the African trypanosome. In Gene Silencing by RNA Interference: Technology and Application. Edited by M. Sohail. Boca Raton, FL, USA: CRC Press.
Mark E. Drew, Shawn A. Motyka, James C. Morris, Zefeng Wang, Paul T. Englund. 2005. Inducible RNAi as a forward genetic tool in Trypanosoma brucei. In RNA Interference Technology. Edited by K. Appasani. Cambridge, UK: Cambridge University Press. 247-256. http://cambridge.org
Continuing Education, Extension, or Other Courses Taught
Guest Lecture
10/30/2008 Drug Development in Infectious Diseases. The Ohio State University College of Pharmacy (Columbus, OH) 15.
3/30/2009 Characterization of essential proteases involved in nutrient acquisition and protein turnover in the malarial parasite, Plasmodium falciparum. University of Michigan (Ann Arbor, MI)
8/13/2009 Proteases as therapeutic drug targets in the human malarial parasite Plasmodium falciparum. The Research Institute at Nationwide Children's Hospital (Columbus, OH)
11/6/2009 Proteases as therapeutic drug targets in the human malarial parasite Plasmodium falciparum. Clemson University (Clemson, SC)
3/19/2010 The protein catabolic pathways of Plasmodium falciparum as antimalarial drug targets. The Ohio State University Center for Microbial Interface Biology (Columbus, OH)
10/8/2010 The Protein Catabolic Pathways of Plasmodium falciparum as Antimalarial Drug Targets. Case Western Reserve University (Cleveland, OH)
10/2011 The protein catabolic pathways of Plasmodium falciparum as antimalarial drug targets. Millennium Pharmaceuticals (Boston, MA)
Degrees
| 1991 | B.A., Seattle Pacific University, Biochemistry |
| 2002 | Ph.D., Johns Hopkins University, School of Medicine, Biochemistry |
Editorial Activities
Ad Hoc Ad Hoc Reviewer
| PLOSOne. (Journal) |
Ad Hoc Reviewer
| 2011 - present | Microbiology. (1 Publication) (Journal) |
| 2009 - present | Journal of Autophagy. (2 Publications) (Journal) (November 22, 2009). |
Reviewer
| 2011 | The Wellcome Trust/DBT India Alliance. (1 Publication) "Senior Fellowship Applications." |
Honors
| Nominated as 2010 Distinguished Undergraduate Mentor. The Ohio State University Honors & Scholars Center. Subject: Student Mentorship |
Outreach
Co-Leader - Infectious Diseases Drug Discovery Interest Group
Project Dates: 2009 - present
Description: A cross-College interest group focused on advancing drug discovery for bacterial, protozoal, viral, and fungal pathogens. Meetings occur quarterly.
Co-Leader - OSU Autophagy Interest Group
Project Dates: 2010 - present
Description: Co-Organizer for monthly interest group on topics relating to the catabolic process of autophagy
2010 Presidential Road's Scholars Tour
Project Dates: 2010 - 2010
Description: Accepted an invitation to attend the 2010 Road's Scholar's Tour
Peer Reviewed Journal Articles
Drew, M, E; Langford, C, K; Klamo, E, M; Russell, D, G; Kavanaugh, M, P; Landfear, S M. 1995. Functional expression of a myo-inositol/H+ symporter from Leishmania donovani. Molecular and cellular biology. Vol. 15, no. 10: 5508-15.
Feagin, J, E; Drew, M E. 1995. Plasmodium falciparum: alterations in organelle transcript abundance during the erythrocytic cycle. Experimental parasitology. Vol. 80, no. 3: 430-40.
Langford, C, K; Kavanaugh, M, P; Stenberg, P, E; Drew, M, E; Zhang, W; Landfear, S M. 1995. Functional expression and subcellular localization of a high-Km hexose transporter from Leishmania donovani. Biochemistry. Vol. 34, no. 37: 11814-21.
Klamo, E, M; Drew, M, E; Landfear, S, M; Kavanaugh, M P. 1996. Kinetics and stoichiometry of a proton/myo-inositol cotransporter. The Journal of biological chemistry. Vol. 271, no. 25: 14937-43.
Vasudevan, G; Carter, N, S; Drew, M, E; Beverley, S, M; Sanchez, M, A; Seyfang, A; Ullman, B; Landfear, S M. 1998. Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant. Proceedings of the National Academy of Sciences of the United States of America. Vol. 95, no. 17: 9873-8.
Carter, N, S; Drew, M, E; Sanchez, M; Vasudevan, G; Landfear, S, M; Ullman, B. 2000. Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant. The Journal of biological chemistry. Vol. 275, no. 27: 20935-41.
Wang, Z; Morris, J, C; Drew, M, E; Englund, P T. 2000. Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. The Journal of biological chemistry. Vol. 275, no. 51: 40174-9.
Abu-Elneel, K; Robinson, D, R; Drew, M, E; Englund, P, T; Shlomai, J. 2001. Intramitochondrial localization of universal minicircle sequence-binding protein, a trypanosomatid protein that binds kinetoplast minicircle replication origins. The Journal of cell biology. Vol. 153, no. 4: 725-34.
Drew, M, E; Englund, P T. 2001. Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates. The Journal of cell biology. Vol. 153, no. 4: 735-44.
Klingbeil, M, M; Drew, M, E; Liu, Y; Morris, J, C; Motyka, S, A; Saxowsky, T, T; Wang, Z; Englund, P T. 2001. Unlocking the secrets of trypanosome kinetoplast DNA network replication. Protist. Vol. 152, no. 4: 255-62.
Morris, J, C; Drew, M, E; Klingbeil, M, M; Motyka, S, A; Saxowsky, T, T; Wang, Z; Englund, P T. 2001. Replication of kinetoplast DNA: an update for the new millennium. International journal for parasitology. Vol. 31, no. 5-6: 453-8.
Morris, J, C; Wang, Z; Drew, M, E; Paul, K, S; Englund, P T. 2001. Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector. Molecular and biochemical parasitology. Vol. 117, no. 1: 111-3.
Grams, Jayleen; Morris, James, C; Drew, Mark, E; Wang, Zefeng; Englund, Paul, T; Hajduk, Stephen L. 2002. A trypanosome mitochondrial RNA polymerase is required for transcription and replication. The Journal of biological chemistry. Vol. 277, no. 19: 16952-9.
Morris, James, C; Wang, Zefeng; Drew, Mark, E; Englund, Paul T. 2002. Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library. The EMBO journal. Vol. 21, no. 17: 4429-38.
Wang, Zefeng; Drew, Mark, E; Morris, James, C; Englund, Paul T. 2002. Asymmetrical division of the kinetoplast DNA network of the trypanosome. The EMBO journal. Vol. 21, no. 18: 4998-5005.
Drew, Mark, E; Morris, James, C; Wang, Zefeng; Wells, Lance; Sanchez, Marco; Landfear, Scott, M; Englund, Paul T. 2003. The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library. The Journal of biological chemistry. Vol. 278, no. 47: 46596-600.
Liu, Jun; Gluzman, Ilya, Y; Drew, Mark, E; Goldberg, Daniel E. 2005. The role of Plasmodium falciparum food vacuole plasmepsins. The Journal of biological chemistry. Vol. 280, no. 2: 1432-7.
Motyka, Shawn, A; Drew, Mark, E; Yildirir, Gokben; Englund, Paul T. 2006. Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei. The Journal of biological chemistry. Vol. 281, no. 27: 18499-506.
Drew, Mark, E; Banerjee, Ritu; Uffman, Eric, W; Gilbertson, Scott; Rosenthal, Philip, J; Goldberg, Daniel E. 2008. Plasmodium food vacuole plasmepsins are activated by falcipains. The Journal of biological chemistry. Vol. 283, no. 19: 12870-6.
Bahar M, Deng Y, Zhu X, He S, Pandharkar T, Drew ME, Navarro-Vázquez A, Anklin C, Gil RR, Doskotch RW, Werbovetz KA, Kinghorn AD. 2011. Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. Bioorganic and Medicinal Chemistry Letters. Vol. 9, no. 21. (May): 2606-2610.
Abandeh FI, Drew ME, Sopirala MM. 2012. Carbapenem-Hydrolyzing Gram-Negative Bacteria: Current Options for Treatment and Review of Drugs in Development. Recent Patents on Anti-Infective Drug Discovery. (Formally Accepted)
He S, Werbovetz KA, Drew ME. 2012. The induction of oxidative stress in T. brucei by the antitrypanosomal dihydroquinolone OSU-40. Antimicrobial Agents and Chemotherapy. (February 6) (Formally Accepted)
Positions
| 2002 - 2008 | Research Associate, Washington University in St. Louis, Medicine, HHMI/Molecular Microbiology. Saint Louis, MO, United States. |
| September 2008 - present | Assistant Professor, The Ohio State University College of Medicine, Medicine, Department of Microbial Infection and Immunity. Columbus, OH, United States. |
| September 2008 - present | Assistant Professor, The Ohio State University College of Pharmacy, Pharmacy, Division of Medicinal Chemistry and Pharmacognosy. Columbus, OH, United States. |
Professional Activities
Conference Participation
| 03/22/2009 - 03/26/2009 | Drug Discovery for Protozoan Parasites. Attendee. Keystone Symposia. Breckenridge, CO, USA. |
| 05/28/2009 - 05/29/2009 | Cell Biology of Malaria: Understanding Infection, Targeting Interventions. Attendee. Johns Hopkins Malaria Research Institute. John Hopkins School of Public Health. Baltimore, MD, USA. |
| 12/04/2009 | Pharmaceutical Assets Portal: Matching Academia and Industry for Drug Repositioning. Attendee. NIH CTSA. NIH Main Campus. Bethesda, MD, USA. |
| 2010 | Midwest Microbial Pathogenesis Conference. Attendee. Midwest Microbial Pathogenesis Conference. Washington University in St. Louis. St. Louis, MO, USA. |
| 09/12/2010 - 09/16/2010 | International Molecular Parasitology Meeting. Moderator. International Molecular Parasitology Meeting. Marine Biological Laboratories. Woods Hole, MA, USA. Key Achievements: Served as invited moderator for the "Drugs and Drug Targets" session |
| 09/10/2011 - 09/14/2011 | International Molecular Parasitology Meeting. Attendee. International Molecular Parasitology Meeting. |
Service to Student Affairs
| 02/2010 | Maximus Essay Evaluator. Honors and Scholars. |
Undergrad., Grad. and Prof. Courses Taught
Autumn 2008. The Ohio State University College of Pharmacy, Chemotherapy of Infectious Diseases 837.
Winter 2009. The Ohio State University College of Medicine, Integrated Biomedical Science Graduate Program (IBGP), Microbial Pathogenesis 740.
Spring 2009. The Ohio State University, Integrated Biology - I 401.
Autumn 2009. The Ohio State University, Integrated Biology I Biology 401.
Autumn 2009. The Ohio State University Department of Microbiology, Molecular Biology of Microbial Pathogenesis Micro 724.
Winter 2010. The Ohio State University College of Pharmacy, Medicinal and Natural Products Chemistry Laboratory Pharmacy 411.
Winter 2010. The Ohio State University College of Medicine, Integrated Biomedical Science Graduate Program (IBGP), Seminar in Integrated Biomedical Sciences IBGP 851.
Autumn 2010. The Ohio State University College of Pharmacy, Chemotherapy of Infectious Diseases 837. .
Autumn 2010. The Ohio State University College of Medicine, Integrated Biomedical Science. Mol Bio Bac Pathog 724. 5 credit hours.
Winter 2011. The Ohio State University College of Pharmacy, Div. of Medicinal Chemistry. Medicinal and Natural Products Chemistry Laboratory Pharm 411. .
Winter 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Biol Humn Dis 2 702.05. 10 credit hours
Winter 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Spring 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Summer 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Autumn 2011. Pharmacy COLMBUS, Pharmacy. Med Chem Lab 411 . 2 credit hours
Autumn 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Mol Bio Bac Pathog 724 . 5 credit hours
Autumn 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Winter 2012. The College of Medicine COLMBUS, Integrated Biomedical Science. Biol Humn Dis 2 702.05. 10 credit hours
Winter 2012. The College of Medicine COLMBUS, Integrated Biomedical Science. Dissertation Res 999 . 18 credit hours
Winter 2012. The College of Medicine COLMBUS, Integrated Biomedical Science. Host Defense 703.02. 3 credit hours
