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Mark E. Drew, PhD


Staff photo

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-5337

Email: drew.47@osu.edu

 

Current OSU Appointment

Research Assistant Professor, SBS-Microbial Infectn/Immunity

 

Advising Narrative

Graduated with Research DistinctionWrote and defended Honors Thesis entitled "Validation of Three Deubiquitinating Proteases in Plasmodium falciparum as Putative Drug Targets"

Chapters in Books

James C. Morris, Zefeng Wang, Shawn A. Motyka, Mark E. Drew, Paul T. Englund. "An RNAi-based genomic library for forward genetics in the African trypanosome." In Gene Silencing by RNA Interference: Technology and Application. Edited by M. Sohail. -. Boca Raton, FL, US|USA: CRC Press, January 2004.

Mark E. Drew, Shawn A. Motyka, James C. Morris, Zefeng Wang, Paul T. Englund. "Inducible RNAi as a forward genetic tool in Trypanosoma brucei." In RNA Interference Technology. Edited by K. Appasani. 247-256. Cambridge: Cambridge University Press, January 2005.

 

Degrees

1991 B.A., Seattle Pacific University

2002 Ph.D., Johns Hopkins University, School of Medicine

 

Editorial Activities

present PLOSOne
2009 - present Journal of Autophagy
2011 - present The Wellcome Trust/DBT India Alliance
2011 - present Microbiology
 

Honors

present Nominated as 2010 Distinguished Undergraduate Mentor. The Ohio State University Honors & Scholars Center.
 

Journal Articles

Langford, C, K; Kavanaugh, M, P; Stenberg, P, E; Drew, M, E; Zhang, W; Landfear, S M. "Functional expression and subcellular localization of a high-Km hexose transporter from Leishmania donovani.." Biochemistry. Vol. 34, no. 37. (January 1995.): 11814-21.

Drew, M, E; Langford, C, K; Klamo, E, M; Russell, D, G; Kavanaugh, M, P; Landfear, S M. "Functional expression of a myo-inositol/H+ symporter from Leishmania donovani.." Molecular and cellular biology. Vol. 15, no. 10. (January 1995.): 5508-15.

Feagin, J, E; Drew, M E. "Plasmodium falciparum: alterations in organelle transcript abundance during the erythrocytic cycle.." Experimental parasitology. Vol. 80, no. 3. (January 1995.): 430-40.

Klamo, E, M; Drew, M, E; Landfear, S, M; Kavanaugh, M P. "Kinetics and stoichiometry of a proton/myo-inositol cotransporter.." The Journal of biological chemistry. Vol. 271, no. 25. (January 1996.): 14937-43.

Vasudevan, G; Carter, N, S; Drew, M, E; Beverley, S, M; Sanchez, M, A; Seyfang, A; Ullman, B; Landfear, S M. "Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 95, no. 17. (January 1998.): 9873-8.

Wang, Z; Morris, J, C; Drew, M, E; Englund, P T. "Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters.." The Journal of biological chemistry. Vol. 275, no. 51. (January 2000.): 40174-9.

Carter, N, S; Drew, M, E; Sanchez, M; Vasudevan, G; Landfear, S, M; Ullman, B. "Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant.." The Journal of biological chemistry. Vol. 275, no. 27. (January 2000.): 20935-41.

Drew, M, E; Englund, P T. "Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates.." The Journal of cell biology. Vol. 153, no. 4. (January 2001.): 735-44.

Klingbeil, M, M; Drew, M, E; Liu, Y; Morris, J, C; Motyka, S, A; Saxowsky, T, T; Wang, Z; Englund, P T. "Unlocking the secrets of trypanosome kinetoplast DNA network replication.." Protist. Vol. 152, no. 4. (January 2001.): 255-62.

Morris, J, C; Wang, Z; Drew, M, E; Paul, K, S; Englund, P T. "Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector.." Molecular and biochemical parasitology. Vol. 117, no. 1. (January 2001.): 111-3.

Morris, J, C; Drew, M, E; Klingbeil, M, M; Motyka, S, A; Saxowsky, T, T; Wang, Z; Englund, P T. "Replication of kinetoplast DNA: an update for the new millennium.." International journal for parasitology. Vol. 31, no. 5-6. (January 2001.): 453-8.

Abu-Elneel, K; Robinson, D, R; Drew, M, E; Englund, P, T; Shlomai, J. "Intramitochondrial localization of universal minicircle sequence-binding protein, a trypanosomatid protein that binds kinetoplast minicircle replication origins.." The Journal of cell biology. Vol. 153, no. 4. (January 2001.): 725-34.

Morris, James, C; Wang, Zefeng; Drew, Mark, E; Englund, Paul T. "Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library.." The EMBO journal. Vol. 21, no. 17. (January 2002.): 4429-38.

Wang, Zefeng; Drew, Mark, E; Morris, James, C; Englund, Paul T. "Asymmetrical division of the kinetoplast DNA network of the trypanosome.." The EMBO journal. Vol. 21, no. 18. (January 2002.): 4998-5005.

Grams, Jayleen; Morris, James, C; Drew, Mark, E; Wang, Zefeng; Englund, Paul, T; Hajduk, Stephen L. "A trypanosome mitochondrial RNA polymerase is required for transcription and replication.." The Journal of biological chemistry. Vol. 277, no. 19. (January 2002.): 16952-9.

Drew, Mark, E; Morris, James, C; Wang, Zefeng; Wells, Lance; Sanchez, Marco; Landfear, Scott, M; Englund, Paul T. "The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library.." The Journal of biological chemistry. Vol. 278, no. 47. (January 2003.): 46596-600.

Liu, Jun; Gluzman, Ilya, Y; Drew, Mark, E; Goldberg, Daniel E. "The role of Plasmodium falciparum food vacuole plasmepsins.." The Journal of biological chemistry. Vol. 280, no. 2. (January 2005.): 1432-7.

Motyka, Shawn, A; Drew, Mark, E; Yildirir, Gokben; Englund, Paul T. "Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei.." The Journal of biological chemistry. Vol. 281, no. 27. (January 2006.): 18499-506.

Drew,Mark,E; Banerjee,Ritu; Uffman,Eric,W; Gilbertson,Scott; Rosenthal,Philip,J; Goldberg,Daniel,E. "Plasmodium food vacuole plasmepsins are activated by falcipains." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 283, no. 19. (May 2008.): 12870-12876.

Drew, Mark, E; Banerjee, Ritu; Uffman, Eric, W; Gilbertson, Scott; Rosenthal, Philip, J; Goldberg, Daniel E. "Plasmodium food vacuole plasmepsins are activated by falcipains.." The Journal of biological chemistry. Vol. 283, no. 19. (January 2008.): 12870-6.

Bahar M, Deng Y, Zhu X, He S, Pandharkar T, Drew ME, Navarro-Vázquez A, Anklin C, Gil RR, Doskotch RW, Werbovetz KA, Kinghorn AD. "Potent antiprotozoal activity of a novel semi-synthetic berberine derivative." Bioorganic and Medicinal Chemistry Letters. Vol. 9, no. 21. (May 2011.): 2606-2610.

He S, Werbovetz KA, Drew ME. "The induction of oxidative stress in T. brucei by the antitrypanosomal dihydroquinolone OSU-40." Antimicrobial Agents and Chemotherapy. (February 2012.): -.

Abandeh FI, Drew ME, Sopirala MM. "Carbapenem-Hydrolyzing Gram-Negative Bacteria: Current Options for Treatment and Review of Drugs in Development." Recent Patents on Anti-Infective Drug Discovery. (January 2012.): -.

Harris, MT, Walker, DM, Drew, ME, Mitchell, WG, Dao, K, Schroeder, CE, Flaherty, DP, Weiner, WS, Golden, JE, Morris, JC.. "Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase." Antimicrobial Agents and Chemotherapy. Vol. 57, (May 2013.): 3731-7.

Walker, DM, Mahfooz, N, Kemme, KA, Patel, VC, Spangler, M, Drew, ME.. "Plasmodium falciparum Erythrocytic Stage Parasites Require the Putative Autophagy Protein PfAtg7 for Normal Growth." PLoS ONE. Vol. 8, (June 2013.): e67047-.

Endeshaw,Molla; Zhu,Xiaohua; He,Shanshan; Pandharkar,Trupti; Cason,Emily; Mahasenan,Kiran,V; Agarwal,Hitesh; Li,Chenglong; Munde,Manoj; Wilson,W,David; Bahar,Mark; Doskotch,Raymond,W; Kinghorn,A,Douglas; Kaiser,Marcel; Brun,Reto; Drew,Mark,E; Werbovetz,Karl,A. "8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity." JOURNAL OF NATURAL PRODUCTS. Vol. 76, no. 3. (March 2013.): 311-315.

 

Professional Activities

2009 - present Pharmaceutical Assets Portal: Matching Academia and Industry for Drug Repositioning. NIH CTSA. Bethesda, MD.
2010 - present Midwest Microbial Pathogenesis Conference. Midwest Microbial Pathogenesis Conference. St. Louis, MO.
2010 - present Maximus Essay Evaluator.
2009 Cell Biology of Malaria: Understanding Infection, Targeting Interventions.. Johns Hopkins Malaria Research Institute. Baltimore, MD.
2009 Drug Discovery for Protozoan Parasites. Keystone Symposia. Breckenridge, CO.
2010 International Molecular Parasitology Meeting. International Molecular Parasitology Meeting. Woods Hole, MA.
2011 International Molecular Parasitology Meeting. International Molecular Parasitology Meeting.