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Jordi B. Torrelles, PhD


Staff photo

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-0777

Email: torrelles.2@osu.edu

 

Current OSU Appointment

Assistant Professor, SBS-Microbial Infectn/Immunity

 

Advising Narrative

Varun Gadkari: 3rd Place for the Best Poster presentation under the category of undergraduate students in Biomedical Sciences, The Ohio State University 17th Annual Denman Undergraduate Research Forum, May 9th, 2012.

Poster title: Human Lung Surfactant Hydrolases Alter the Mycobacterium tuberculosis Cell Surface Influencing the Human Macrophage Capacity to Control the Infection. Gadkari V, Arcos J, Sasindran SJ, Diangelo L, and Torrelles JB. The Ohio State University, Columbus, OH.



Poornima Venigalla : A Biomedical Science (BMS) student in my lab obtained "The URO 2013 Summer Research Fellowship" to perform basic research in my lab druing the summer term. As stated in the award notification letter: "Poornima wrote a very compelling proposal and the letter from her research mentor demonstrates a deep commitment to her and her project".

Academic Advising

I am currently mentoring several post-doctoral, doctoral, masters, and undergraduate students as well as technical staff. In this regard, I have always my office door open to all the students/staff within my department and center seeking for research and/or personal advice. I was fortunate that during my doctoral and post-doctoral studies to have outstanding mentors from which I learnt how to become a scientist deeply implicated in education and research. As a faculty member, I am targeting the formation of a competitive and intellectual research group bringing new ideas and technology to the field. However, a part of directing a successful scientific program, one of my goals is to devote part of my time to teach young students/scientists and to transfer to them my knowledge and enthusiasm for science in order to enable them to move on to become successful scientists and academic scholars within the scientific community. This is noted in the large number of abstracts in my dossier, which reflects my enthusiasm in mentoring having my lab personnel (students and staff) presenting their data in local (i.e. OSUCOM research day, CMIB retreat, PHPID research day), regional/national (i.e. Midwest Pathogenesis meeting, ASM) and international (i.e., Keystone) meetings. My believe is that learning how to present your data (first writing an abstract and then presenting your data, even in a poster format) is critical in the learning curve of any successful scientist.

Chapters in Books

Shi L, Torrelles JB, and Chatterjee D. "Lipoglycans of Mycobacterium tuberculosis: Isolation, purification and characterization." In Mycobacterial Protocols. Methods in Molecular Biology.. Vol. 465. Edited by Parish T and Stoker NG. 23-45. Totowa, NJ, US|USA: Humana Press, July 2008.

Schlesinger LS, Azad AK, Torrelles JB, Roberts E, Vergne I and Deretic V. "Determinants of phagocytosis, phagosome biogenesis and autophagy for Mycobacterium tuberculosis." In Tuberculosis: Immunology and Cell Biology. Vol. 1. Edited by Kaufmann and Britton. 1-22. Weinheim, DE|DEU: Wiley-VCH Verlag, GmbH & Co. KGaA, January 2008.

Torrelles JB. "Broadening the view about the role of Mycobacterium tuberculosis cell envelope components during infection: A battle for survival." In Understanding Tuberculosis - Analyzing the origin of Mycobacterium tuberculosis pathogenesis/Book 3. Book 3 ed. Vol. 4. Edited by Cardona PJ. 75-122. Rijeka, HR|HRV: InTech, February 2012.

 

Conferences

Torrelles JB, Sieling PA, Khoo KH, Sue-Mei H, Modlin RL and Chatterjee D. "Isoforms of lipoarabinomannan from Mycobacterium tuberculosis that are recognized by CDI-restricted T-cells: Their potential role in mediating immune responses in human." In GLYCOBIOLOGY. (October 2002). 671-.

Khasnobis S., Torrelles JB, McNeil M. and Chatterjee D. "On arabinan biosynthesis in arabiongalactan and lipoarabionomannan: The mycobacterial cell wall polysaccharides.." In GLYCOBIOLOGY. (October 2002). 707-.

Sieling,P,A; Torrelles,J; Chung,W; Rea,T,H; Brennan,P,J; Chatterjee,D; Porcelli,S,A; Modlin,R,L. "Subversion of the human CD1-restricted T cell repertoire in leprosy infection." In FASEB JOURNAL. (April 2003). C173-.

Berg S, Torrelles JB, Chatterjee D, Crick DC, Escuyer VE and Brennan PJ. "Point Mutations in embC Affect Synthesis of Lipoarabinomannan in Mycobacterium smegmatis." In GLYCOBIOLOGY. (November 2003). 853-.

Schlesinger LS, Torrelles JB, Azad AK, Ackelson A, and McCarthy TR. "M. tuberculosis cell wall mannosylated lipoglycans: Elucidation of structural motifs that impact on human macrophage recognition and response.." In US-Japan Cooperative Medical Science Program. $0th Tuberculosis and Leprosy Research Conference. (January 2005). 184-188.

Torrelles JB, Kaufman T, Knaup R, Hill P, Slepushkina T, Kolareth A, Kang P, Chatterjee D, Belisle JT, Brennan PJ, Musser JM and Schlesinger LS. "Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis: Impact on interactions with the human host." Glycobiology. (January 2007). 1124-1125.

Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, Kang P, Hill PJ, Brennan PJ, Chatterjee D, Belisle JT, Musser JM, and Schlesinger LS. "A subset of Mycobacterium tuberculosis clinical isolates within a defined genetic linkage differentially interact with human macrophages due to a truncated lipoarabinomannan and reduced higher-order phosphatidyl-myo-inositol mannosides." In US-Japan Cooperative Medical Science Program. 43th Tuberculosis and Leprosy Research Conference. (January 2008). 20-24.

Schlesinger LS, Morris, J, Brooks MN, Torrelles JB, Azad A and Rajaram MVS.. "Mycobacterium tuberculosis activates PPAR-gamma, a key regulator of human macrophage immune responses, through ligation of the mannose receptor.." In US-Japan Cooperative Medical Science Program in Tuberculosis and Leprosy. 45th Annual Joint Panel Research Conference, Special Topics in Genomics and Other-omics Workshops. (January 2010). 39-45.

Schlesinger LS, Ni B, Morris J, Brooks MN, Carlson TK, Torrelles JB, and Rajaram MVS. "Mycobacterium tuberculosis infection regulates the expression of microRNAs and regulates human macrophage immune responses." In US-Japan Cooperative Medical Science Program. 46th Tuberculosis and Leprosy Research Conference. (January 2011). 1-5.

 

Degrees

1996 B.S., Universitat Autònoma of Barcelona

2000 M.S., Universitat Autònoma of Barcelona

2003 Ph.D., Universitat Autònoma of Barcelona

 

Editorial Activities

2001 - present Tuberculosis
2006 - present FEMs Immunology and Clinical Microbiology
2008 - present Glycobiology
2009 - present Journal of Biological Chemistry
2009 - present Drugs od the future
2009 - present Journal of Leukocyte Biology
2010 - present Journal of Glycomics and Lipidomics
2010 - present Frontiers in Cellular Microbiology
2010 - present Microbiology
2010 - present Journal of Biotechnology
2010 - present FASEB J
2010 - present BioMed Central
2011 - present Proceedings of the National Academy of Sciences USA
2011 - present PLoS Pathogens
2011 - present PLoS One
2011 - present Translational Research
2012 - present PLoS One
2012 - present Innate Immunity
 

Honors

2003 Distinction to Excellence in Research. The Ministry of Education of Spain.
2003 - 2008 Post-doctoral Fellowship, NIH-NIAID, The Ohio State University, USA. OSU-Internal Medicine.
2006 NIAID Keystone Scholarship (Innate Immunity). NIH/NIAID.
2006 James V. Warren Award as recognition of outstanding and excellence in research performed in the Department of Internal Medicine at The Ohio State University. OSU-Internal Medicine.
2007 Travel award from the Society for Glycobiology. Society for Glycobiology.
2007 The Ohio State University Medical Center Candidate elected for the 2008 Parker B. Francis Fellowship. OSU-Office of Research.
2008 - 2011 Parker B. Francis Fellowship in Pulmonary research. Parker B. Francis.
2009 The Ohio State University Candidate elected for the 2010 Pew Scholar Fellowship. OSU-Office of Research.
2010 The Ohio State University Candidate elected for the 2011 Burroughs Wellcome Fund Program. OSU-Office of Research.
2012 Public Health Preparedness for Infectious Diseases Travel Fellowship. Public Health Preparedness for Infectious Diseases-College of Public Health, The Ohio State University.
2012 The Ohio State University Candidate elected for the 2013 Burroughs Wellcome Fund Program. OSU-Office of Research.
 

Journal Articles

Muñoz M, Laneelle MA, Luquin M, Torrelles JB, Julian E, Ausina V, Daffe M.. "Occurrence of an antigenic triacyl trehalose in clinical isolates and reference strains of Mycobacterium tuberculosis.." FEMS Microbiology Letters. Vol. 157, no. 2. (December 1997.): 251-259.

Thorton CG, Cranflied MR, MacLellan KM, Brink TL Jr, Strandberg JD, Carlin EA, Torrelles JB, Maslow JN, Hasson JL, Heyl DM, Sarro SJ, Chatterjee D and Passen S. "Processing postmortem specimens with C18-carboxypropylbetaine and analysis by PCR to develop an antemortem test for Mycobacterium avium infections in ducks." Journal of Zoo and Wildlife Medicine. Vol. 30, no. 1. (March 1999.): 11-24.

Khoo KH, Jarboe E, Barker A, Torrelles JB, Kuo CW and Chatterjee D.. "Altered expression profile of the surface glycopeptidolipids in drug-resistant clinical isolates of Mycobacterium avium complex." Journal of Biological Chemistry. Vol. 274, no. 14. (April 1999.): 9778-9785.

Torrelles JB, Chatterjee D., Lonca, J., Manterola, JM., Ausina, V. and Brennan, PJ.. "Serovars of Mycobacterium avium complex isolated from AIDS and non-AIDS patients in Spain." Journal of Applied Microbiology. Vol. 88, no. 2. (February 2000.): 266-279.

Escuyer VE, Lety MA, Torrelles JB, Frehel C, McNeil MR, Brennan PJ and Chatterjee D.. "The role of embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan." Journal of Biological Chemistry. Vol. 276, no. 52. (December 2001.): 48854-48862.

Fisher K, Chatterjee D, Torrelles JB, Brennan PJ, Kaufmann SHE and Schaible UE. "Mycobacterial lysocardiolipin is exported from phagosomes upon cleavage of cardiolipin by a macrophage-derived lysosomal phospholipase A2." Journal of Immunology. Vol. 15, no. 4. (January 2001.): 2187-2192.

Torrelles JB, Ellis D, Osborne T, Hoefer A, Orme IM, Chatterjee D, BrennanPJ and Cooper A. "Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104." Tuberculosis. Vol. 82, no. 6. (January 2002.): 293-300.

Zhang N*, Torrelles JB*, McNeil MR, Escuyer VE, Brennan PJ, Khoo K-H, and Chatterjee D. "The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a C-terminal synthetic region." Molecular Microbiology. Vol. 50, no. 1. (October 2003.): 69-76.

Rhoades E, Hsu F-F, Torrelles JB, Turk J, Chatterjee D, and Russell DG. "Characterization of mycobacterial glycolipids released within host macrophages." Molecular Microbiology. Vol. 48, (January 2003.): 875-888.

Torrelles JB, Khoo KH, Sieling PA,Modlin RL, Zhang N, Marques AM,Treumann A, Rithner CD, Brennan PJ, and Chatterjee D. "Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis." Journal of Biological Chemistry. Vol. 279, no. 39. (September 2004.): 41227-41239.

Kang PB, Azad AK, Torrelles JB, Kaufman TM, Beharka A, Tibesar E, Desjardin LE, Schlesinger LS. "The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis.." Journal of Experimental Medicine. Vol. 202, no. 7. (October 2005.): 987-999.

McCarthy TR*, Torrelles JB*, Macfarlane AS, Katawczik M, Kutzbach B, Desjardin LE, Clegg S, Goldberg JB, Schlesinger LS. "Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages.." Molecular Microbiology. Vol. 58, no. 3. (November 2005.): 774-790.

Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, and Modlin RL. "The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: Implications for host responses against immunologically related pathogens.." Journal of Immunology. Vol. 174, no. 5. (March 2005.): 2637-2644.

Berg S, Starbuck J, Torrelles JB, Vissa VD, Crick DC, Chatterjee D, Brennan PJ. "Roles of conserved proline and glycosyltransferase motifs of EmbC in biosynthesis of lipoarabinomannan.." Journal of Biological Chemistry. Vol. 280, no. 7. (February 2005.): 5651-5663.

Torrelles JB, Azad AK, and Schlesinger LS. "Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors.." Journal of Immunology. Vol. 177, no. 3. (August 2006.): 1805-1816.

Lee A, Wu SW, Scherman MS, Torrelles JB, Chatterjee D, McNeil MR and Khoo K-H. "Sequencing of oligoarabinosyl units released from mycobacterial arabinogalactan and lipoarabinomannan by endogenous arabinanase: Identification of distinctive and novel structural motifs.." Biochemistry. Vol. 45, no. 51. (December 2006.): 15817-15828.

Hall-Stoodley L, Watts G, Crowther JE, Balapogal A, Torrelles JB, Robison-Cox J, Bargatze RF, Harmsen AG, Crouch EC, and Schlesinger LS. "Mycobacterium tuberculosis Binding to human surfactant proteins A and D, fibronectin and small airway epithelial cells under shear.." Infection and Immunity. Vol. 74, no. 6. (June 2006.): 3587-3596.

Wittkowski M, Mittelstädt J, Brandau S, Reiling N, Lindner B, Torrelles JB, Brennan PJ, Holst O. "Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity.." Journal of Biological Chemistry. Vol. 282, no. 26. (June 2007.): 19103-19112.

Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, Kang P, Hill PJ, Brennan PJ, Chatterjee D, Belisle JT, Musser JM, and Schlesinger LS. "Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan.." Journal of Biological Chemistry. Vol. 283, no. 46. (November 2008.): 31417-31428.

Azad AK, Torrelles JB, and Schlesinger LS. "Mutation in DC-SIGN cytoplasmic triacidic cluster motif attenuates the receptor in both phagocytosis and endocytosis of mannose-containing ligands by human myeloid cells." Journal of Leukocyte Biology. Vol. 84, no. 6. (December 2008.): 1594-1603.

Torrelles JB, Azad AK, Henning LH, Carlson TK and Schlesinger LS. "Role of C-type lectins in mycobacterial infections.." Current Drug Targets. Vol. 9, no. 2. (February 2008.): 102-112.

Carlson TK, Torrelles JB, Smith K, Horlacher T, Castelli R,Seeberger PH, Crouch EC, and Schlesinger LS. "Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis." Glycobiology. Vol. 19, no. 12. (December 2009.): 1473-1484.

Shi L,Torrelles JB, and Chatterjee D. "Lipoglycans of Mycobacterium tuberculosis: isolation, purification, and characterization.." Methods in molecular biology (Clifton, N.J.). Vol. 465, (January 2009.): 23-45.

Torrelles JB*, Desjardin LE*, MacNeil J, Kaufman TM, Kutzbach B, Knaup R, McCarthy TR, Gurcha SS, Besra GS, Clegg S, and Schlesinger LS. "Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death." Glycobiology. Vol. 19, no. 7. (July 2009.): 743-755.

Gangaiah D., Liu Z, Arcos J, Kassem II, Sanad Y, Torrelles JB and Rajashekara G. "Polyphosphate kinase 2: A novel determinant of stress responses and pathogenesis in Campylobacter jejuni.." PLOS One. Vol. 5, no. 8. (August 2010.): e12142-.

Torrelles JB and Schlesinger LS. "Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host." Tuberculosis. Vol. 90, no. 2. (March 2010.): 84-93.

Rajaram MVS, Morris JD, Brooks MN, Torrelles JB, Azad AK, Schlesinger LS. "Mycobacterium tuberculosis activates human macrophage PPARγ linking mannose receptor recognition to regulation of immune responses.." J. Immunology. Vol. 185, no. 2. (July 2010.): 929-942.

Dwivedi V, Manickam C, Patterson R, Dodson K, Murtaugh M, Torrelles JB, Schlesinger LS, Renukaradhya GJ. "Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant.." Vaccine. Vol. 29, no. 23. (May 2011.): 4058-4066.

Rajaram MVS, Morris JD, Brooks MN, Carlson TK, Torrelles JB and Schlesinger LS. "Mycobacterium tuberculosis lipomannan blocks TNF-gamma biosynthesis in human macrophages by regulation of MAP kinase-activated protein kinase 2 (MK2) and miR125b." Proceedings of the National Academy of Sciences. Vol. 108, (August 2011.): 17408-17413.

Binjawadagia B, Dwivedia V, Manickama C, Pattersona R, Torrelles JB, and Renukaradhya GJ. "Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS production." Viral Immunology. Vol. 24, no. 6. (January 2011.): 475-482.

Sasindran SJ and Torrelles JB. "Mycobacterium tuberculosis infection and inflammation: What is beneficial for the host and for the bacterium?." Frontiers in Cellular and Infection Microbiology. Vol. 2, no. 2. (January 2011.): 1-16.

Arcos J, Sasindran SJ, Fujiwara N, Turner J, Schlesinger LS and Torrelles JB. "Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection." The Journal of Immunology. Vol. 187, (April 2011.): 372-381.

Torrelles JB, Sieling PA, Arcos J, Knaup R, Bartling C, Rajaram MVS, Modlin RL and Schlesinger LS. "Structural differences in lipomannans from pathogenic and non- pathogenic mycobacteria and their implications for CD1b-restricted T cell proliferation." Journal of Biological Chemistry. Vol. 286, no. 41. (October 2011.): 35438-35446.

Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, and Chatterjee D. "Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells." Glycobiology. Vol. 22, no. 8. (August 2012.): 1118-1127.

Guirado E, Arcos J, Knaup R, Reeder R, Betz B, Cotton C, Patel T, Pfaller S, Torrelles JB, and Schlesinger LS. "Characterization of Clinical and Environmental Mycobacterium avium Spp. Isolates and Their Interaction with Human Macrophages." PLoS One. Vol. 7, no. 9. (September 2012.): e45411-.

Yang L, Sinha T, Carlson TC, Keiser TL, Torrelles JB, Schlesinger LS. "Changes in the major cell envelope components of Mycobacterium tuberculosis during in vitro growth." Glycobiology. -.

 

Presentations

"Serovars of Mycobacterium avium complex isolated from AIDS and non-AIDS patients in Spain." Presented at Keystone Symposium in Tuberculosis: Molecular Mechanisms and Immunological Aspects/Opportunistic Infections Diseases in AIDS, Keystone, CO, US|USA. (April 1998)

"Serovars of Mycobacterium avium complex isolated from AIDS and non-AIDS patients in Spain." Presented at Keystone Symposia in Tuberculosis: Molecular Mechanisms and Immunological Aspects/Opportunistic Infections Diseases in AIDS, Keystone, CO, US|USA. (April 1998)

"Role of the lipoarabinomannan (LAM) in the pathogenicity of Tuberculosis: Importance as a target for antibiotics." Presented at 1st International Seminar on Advances in Antituberculosis Therapy, Barcelona, Barcelona, ES|ESP. (September 1999)

"Identification of glycoproteins in Mycobacterium avium." Presented at 20th International Carbohydrate Symposium, Hamburg, DE|DEU. (September 2000)

"Alteration in the structure of lipoarabinomannan as a consequence of ethambutol treatment in M. tuberculosis." Presented at Keystone Symposia on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era, Taos, NM, US|USA. (January 2001)

"Involvement of the emb genes in the arabinan biosynthesis." Presented at Keystone Symposia on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era, Taos, NM, US|USA. (January 2001)

"Defining the structure and functional characteristics of distinct isoforms of LAM from Mycobacterium tuberculosis H37Rv." Presented at Keystone Symposia on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era, Taos, NM, US|USA. (January 2001)

"Isoforms of Lipoarabinomannan from Mycobacterium tuberculosis that are recognized by CD1-restricted T cells." Presented at 1st Mycobacteria Research Laboratories Retreat, Pingree Park, CO, US|USA. (September 2002)

"Defining the mechanism of the biochemical and genetic basis of ethambutol-resistance." Presented at XXIst International Carbohydrate Symposium, Cairns, AU|AUS. (July 2002)

"Isoforms of Lipoarabinomannan from Mycobacterium tuberculosis that are recognized by CD1-restricted T-cells: Their potential role in mediating immune responses in human.." Presented at Glycobiology 2002 Meeting, Boston, MA, US|USA. (November 2002)

"On arabinnan biosynthesis in arabinogalactan and lipoarabinomannan: The mycobacterial cell wall polysaccharides." Presented at Glycobiology 2002 Meeting, Boston, MA, US|USA. (November 2002)

"Characterization of Lipoarabinomannan Isoforms of Mycobacterium tuberculosis responsible for precise recognition by CD1-restricted T cells." Presented at Keystone Symposia on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era, Taos, NM, US|USA. (January 2003)

"IThe role of Mycobacterium tuberculosis phosphomannomutases in the biosynthesis of cell wall glycoconjugates." Presented at 10th Mid-West Pathogenesis 2003 Meeting, Iowa City, IA, US|USA. (October 2003)

"Point Mutations in embC affect synthesis of lipoarabinomannan in Mycobacterium smegmatis." Presented at Glycobiology 2003 Meeting, San Diego, CA, US|USA. (December 2003)

"On arabinan biosynthesis of mycobacterial cell wall arabinogalactan." Presented at Keystone Symposia on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era, Taos, NM, US|USA. (January 2003)

"The role of Mycobacterium tuberculosis phosphomannomutases in the biosynthesis of cell wall glycoconjugates." Presented at 3rd Annual OSUMC Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (April 2004)

"Characterization of manB, a functional Mycobacterium tuberculosis phosphomannomutase involved in the biosynthesis of surface expressed mannosylated glycoconjugates." Presented at 11th Mid-West Microbial Pathogenesis 2004 Meeting, East Lansing, MI, US|USA. (September 2004)

"Biochemical characterization of the cell envelope from mycobacterial strains over-expressing genes involved in mannose biosynthesis in Mycobacterium tuberculosis." Presented at 3rd Annual OSUMC Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (April 2004)

"Characterization of the association of purified phosphatidylinositol mannoside species from Mycobacterium tuberculosis with the human macrophage mannose receptor." Presented at 4rd Annual OSUMC Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (March 2005)

"TCharacterization of the association of purified phosphatidylinositol mannoside species from Mycobacterium tuberculosis with the human macrophage mannose receptor." Presented at Keystone Symposia 2005, Tuberculosis, Whistler, CA|CAN. (April 2005)

"Characterization of manB, a functional Mycobacterium tuberculosis phosphomannomutase involved in the biosynthesis of surface expressed mannosylated glycoconjugates." Presented at Keystone Symposia 2005, Tuberculosis, Whistler, CA|CAN. (April 2005)

"Identification and characterization of Mycobacterium tuberculosis genes encoding phosphomannomutase/phosphoglucomutase activity." Presented at 12th Mid-West Pathogenesis 2005 Meeting, Minneapolis, MN, US|USA. (October 2005)

"The nature of the inflammatory response to Mycobacterium tuberculosis cell wall carbohydrates by alternatively activated macrophages." Presented at 4rd Annual OSUMC Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (March 2005)

"The human macrophage mannose receptor directs Mycobacterium tuberculosis manose-capped lipoarabinomannan in limiting phagosome-lysosome fusion in mammalian cells." Presented at US-Japan cooperative medical science Meeting 2005, Seattle, WA, US|USA. (July 2005)

"Characterization of manB, a functional Mycobacterium tuberculosis phosphomannomutase involved in the biosynthesis of surface expressed mannosylated glycoconjugates." Presented at 4rd Annual OSUMC Graduate and Postgraduate Research Day, Columbus, OH, US|USA. (March 2005)

"Phosphatidyl-myo-inositol mannosides at the corner of Mycobacterium tuberculosis pathogenesis." Presented at 3rd Mycobacteria Research Laboratories Retreat, Fort Collins, CO, US|USA. (June 2006)

"Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors." Presented at Keystone Symposia 2006, Innate Immunity, Banff, AB, CA|CAN. (February 2006)

"Differential activation of Nods in human macrophages by cell wall lipoarabinomannan from Mycobacterium tuberculosis and an avirulent Mycobacterium spp." Presented at 5th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (March 2006)

"Fine recognition of mannosylated cell wall components of Mycobacterium tuberculosis and by trimeric subunits of surfactant protein D." Presented at 5th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (March 2006)

"Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors." Presented at 5th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (March 2006)

"A genetic clone of Mycobacterium tuberculosis that has altered interactions with human macrophages and variation in ManLAM structure." Presented at 1st CMIB Retreat, Columbus, OH, US|USA. (June 2007)

"Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis dictates interactions with the human host." Presented at Meeting of the Society for Glycobiology, Boston, MA, US|USA. (November 2007)

"Fine recognition of mannosylated cell wall components of Mycobacterium tuberculosis and by trimeric subunits of surfactant protein D." Presented at 6th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (March 2007)

"Fine recognition of mannosylated cell wall components of Mycobacterium tuberculosis and by trimeric subunits of surfactant protein D." Presented at 1st CMIB Retreat, Columbus, OH, US|USA. (June 2007)

"DC-SIGN cytoplasmic motifs regulate phgocytosis and phagosome-lysosome fusion events mediated by Mycobacterium tuberculosis mannose-capped lipoarabinomannan in myeloid cells." Presented at Keystone Symposia 2007, The Macrophage: Homeostasis, Immunoregulation and Disease, Cooper Mountain, CO, US|USA. (April 2007)

"Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis dictates interactions with the human host." Presented at 2nd MidWest Carbohydrates and Glycobiology Symposium, Columbus, OH, US|USA. (October 2007)

"Differential activation of NODs in human macrophages by lipomannan and mannose-capped lipoarabinomannan from Mycobacterium tuberculosis." Presented at 6th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (March 2007)

"A genetic clone of Mycobacterium tuberculosis that has altered interactions with human macrophages and variation in ManLAM structure." Presented at Keystone Symposia 2007, Tuberculosis: From Lab research to Field Trials, Vancouver, BC, CA|CAN. (March 2007)

"A genetic clone of Mycobacterium tuberculosis that has altered interactions with human macrophages and variation in ManLAM structure." Presented at 6th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (March 2007)

"Lipidomics of the Mycobacterium tuberculosis mannose-capped lipoarabinomannan phagosome in human macrophages." Presented at 1st CMIB Retreat, Columbus, OH, US|USA. (June 2007)

"DC-SIGN cytoplasmic motifs regulate phgocytosis and phagosome-lysosome fusion events mediated by Mycobacterium tuberculosis mannose-capped lipoarabinomannan in myeloid cells." Presented at 1st CMIB Retrreat, Columbus, OH, US|USA. (June 2007)

"Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis: Impact on interactions with the human host." Presented at Unitat de Tuberculosis Experimental (UTE) Seminar Series, Badalona, Barcelona, ES|ESP. (October 2008)

"Deletion of the Mannosyltransferase PimB reduces surface expression of the cell wall lipoarabinomannan in Mycobacterium tuberculosis affecting the rate of macrophage cell death." Presented at 2nd CMIB Retreat, Columbus, OH, US|USA. (September 2008)

"Virulence factors of Mycobacterium avium complex from drinking water." Presented at 2nd CMIB Retreat, Columbus, OH, US|USA. (September 2008)

"Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages." Presented at 2nd CMIB Retreat, Columbus, OH, US|USA. (September 2008)

"Deletion of the Mannosyltransferase PimB reduces surface expression of the cell wall lipoarabinomannan in Mycobacterium tuberculosis affecting the rate of macrophage cell death." Presented at 7th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (April 2008)

"Recognition of Mycobacteria species and mannosylated cell wall components by collagen deletion trimeric subunits of surfactant D." Presented at 7th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (April 2008)

"C-type lectin DC-SIGN cytoplasmic motif regulates receptor activity in human myeloid cells." Presented at 2nd CMIB Retreat, Columbus, OH, US|USA. (September 2008)

"C-type lectin DC-SIGN cytoplasmic motif regulates receptor activity in human myeloid cells." Presented at Keystone TB Symposium 2009. Tuberculosis: Biology, Pathology and Therapy, Keystone, CO, US|USA. (January 2009)

"Remodeling of the Mycobacterium tuberculosis cell wall by enzymes in the lung microenvironment alter bacterial recognition and fate in human macrophages." Presented at 4th Annual Dorothy Hearth and Lung Research Institute Research Day, Columbus, OH, US|USA. (October 2009)

"Mycobacterium tuberculosis mannose-capped lipoarabinomannan alters the human macrophage immune response through the nuclear receptor PPAR-gamma." Presented at Keystone TB Symposium 2009. Tuberculosis: Biology, Pathology and Therapy, Keystone, CO, US|USA. (January 2009)

"Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages." Presented at Keystone TB Symposium 2009. Tuberculosis: Biology, Pathology and Therapy, Keystone, CO, US|USA. (January 2009)

"Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages." Presented at 8th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (April 2009)

"Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages." Presented at Advances in Veterinary Medicine Day, Columbus, OH, US|USA. (April 2009)

"Biosynthesis of a Mycobacterium tuberculosis enzyme (PPM) that generates key mannose donors for cell envelope mannose-containing lipoglycans important in bacterial virulence." Presented at 8th Annual OSUMC Graduate & Postgraduate Research Day, Columbus, OH, US|USA. (April 2009)

"Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host." Presented at Mycobacteria Research Laboratories Seminar Series, Fort Collins, CO, US|USA. (March 2010)

"Mycobacterium tuberculosis activation of human macrophage PPARg links to the mannose receptor in regulating immune responses." Presented at 3rd Center for Microbial Interface Biology Research Retreat, Columbus, OH, US|USA. (March 2010)

"Cloning and characterization of genes involved in the biosynthetic pathway fro cell envelope mannose-containing lypoglycans in Mycobacterium tuberculosis." Presented at 3rd Center for Microbial Interface Biology Research Retreat, Columbus, OH, US|USA. (March 2010)

"Remodeling of the Mycobacterium tuberculosis cell wall by enzymes in the lung microenvironment alter bacterial recognition and fate in human macrophages." Presented at 3rd Center for Microbial Interface Biology Research Retreat, Columbus, OH, US|USA. (March 2010)

"Influence of Human Lung Hydrolases on Mycobacterium tuberculosis Infection." Presented at 4th Annual Dorothy Hearth and Lung Research Institute Research Day, Columbus, OH, US|USA. (October 2010)

"Enhanced binding of the pulmonary surfactant protein-D mutant, R343V, to Mycobacterium tuberculosis, a potential immunotherapy." Presented at 3rd Center for Microbial Interface Biology Research Retreat, Columbus, OH, US|USA. (March 2010)

"Characterization of a Mycobacterium tuberculosis operon that regulates mannosylation of the mycobacterial cell wall." Presented at Mid-West Microbial Pathogenesis Conference, San Louis, MO, US|USA. (September 2010)

"Effects of lung mucosal hydrolases on Mycobacterium tuberculosis pathogenesis." Presented at “Germans Trias i Pujol” University Hospital, Clinical Microbiology and Immunology Unit Seminar Series, Badalona, Barcelona, ES|ESP. (April 2010)

"Structural differences in lipomannans from pathogenic and non-pathogenic mycobacteria and their impact on CD1b-restricted T cell proliferation." Presented at The New England Tuberculosis Symposium, Cambridge, MA, US|USA. (July 2010)

"The metabolism of a key Mycobacterium tuberculosis cell wall lipoglycan mannose-capped lipoarabinomannan (ManLAM) in human macrophages.." Presented at 3rd Center for Microbial Interface Biology Research Retreat, Columbus, OH, US|USA. (March 2010)

"Consuming Consumption: Lung mucosal hydrolases and Mycobacterium tuberculosis pathogenesis." Presented at “Germans Trias i Pujol” University Hospital, Clinical Microbiology and Immunology Unit Seminar Series, Badalona, Barcelona, ES|ESP. (September 2011)

"Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis in human macrophages by regulation of MAP kinase-activated protein kinase 2 (MK2) and mir125b." Presented at Keystone TB Symposium 2011. Tuberculosis: Immunology, Cell Biology and Novel vaccination Strategies, Vancouver, BC, CA|CAN. (January 2011)

"Characterization of a Mycobacterium tuberculosis operon that regulates mannosylation of the mycobacterial cell wall." Presented at Keystone TB Symposium 2011. Tuberculosis: Physiology, Metabolism and Pathogenesis – Back to the Basics, Vancouver, BC, CA|CAN. (January 2011)

"Lung mucosal hydrolases and Mycobacterium tuberculosis pathogenesis." Presented at 2011 FASEB Summer Conferences, Microbial Polysaccharides of Medical, Agricultural, and Industrial Importance, Carefree, AZ, US|USA. (May 2011)

"Biochemical properties of Mycobacterium tuberculosis cell wall fragments released following exposure to human hydrolases and their impact in the capacity of controlling infection by human macrophages." Presented at 3rd CMIB Retreat, Columbus, OH, US|USA. (September 2011)

"Characterization of a Mycobacterium tuberculosis operon that regulates mannosylation of the mycobacterial cell wall." Presented at 10th Annual OSUMC Trainee Research Day, Columbus, OH, US|USA. (April 2011)

"Characterization of the Production of Mycobacterium tuberculosis lipoarabinomannan, lipomannan and phosphatidyl-myo-inositol mannosides during bacterial growth." Presented at 3rd CMIB Retreat, Columbus, OH, US|USA. (September 2011)

"Consuming Consumption: Lung mucosal hydrolases and Mycobacterium tuberculosis pathogenesis." Presented at Mycobacteria Research Laboratories Seminar Series, Bellaterra, Catalonia, Barcelona, ES|ESP. (September 2011)

"Lung hydrolases alter the infection outcome of Mycobacterium tuberculosis in human macrophages." Presented at Keystone TB Symposium 2011. Tuberculosis: Immunology, Cell Biology and Novel vaccination Strategies, Vancouver, BC, CA|CAN. (January 2011)

"The mannose-capped lipoarabinomannan phagosome lipid composition and its implications on the intracellular survival of Mycobacterium tuberculosis within human macrophages." Presented at 2011 Denman Undergraduate Research Forum, Columbus, OH, US|USA. (May 2011)

"Effects of Mycobacterium tuberculosis cell wall fragments released by the action of human lung hydrolases in the host immune response." Presented at 3rd CMIB Retreat, Columbus, OH, US|USA. (September 2011)

"The host immune response induced by Mycobacterium tuberculosis cell wall fragments released by the action of human lung surfactant hydrolases." Presented at 6th Annual Dorothy D. Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (October 2011)

"Biochemical nature of Mycobacterium tuberculosis cell wall fragments released by exposure to human lung surfactant hydrolases and their capacity to enhance the control of infection by human macrophages." Presented at 6th Annual Dorothy D. Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (October 2011)

"Structural differences in lipomannan from pathogenic and non-pathogenic mycobacteria and their impact on CD1b-restricted T cell proliferation." Presented at Keystone TB Symposium 2011. Tuberculosis: Physiology, Metabolism and Pathogenesis – Back to the Basics, Vancouver, BC, CA|CAN. (January 2011)

"Effects of the human lung environment in Mycobacterium tuberculosis pathogenesis." Presented at Kwa-Zulu Natal Research Institute for Tuberculosis and HIV (K-RITH) Seminar Series, Durban, ZA|ZAF. (July 2011)

"Who are we at OSU?." Presented at Division of Global HIV/AIDS (DGHA) Centers for Disease Control and Prevention Central American Region (CDC-CAR) Seminar Series, Guatemala City, GT|GTM. (September 2012)

"Consuming Consumption: How the lung environment determines Mycobacterium tuberculosis pathogenesis." Presented at Roosevelt Hospital Internal Medicine Ground Rounds, Guatemala City, GT|GTM. (September 2012)

"Who are we at OSU?." Presented at 1-Day Symposium on TB diagnostics in Guatemala, Guatemala City, GT|GTM. (August 2012)

"Consuming Consumption: How the lung environment determines Mycobacterium tuberculosis pathogenesis." Presented at AIDS and Society Non-Governmental Organization Symposium, Escuintla, GT|GTM. (September 2012)

"Functional characterization of PPX/GPPA enzymes of Campylobacter jejuni." Presented at 2012 Public Health Preparedness for Infectious Diseases Forum, Columbus, OH, US|USA. (April 2012)

"Diangelo L, Arcos J, Sasindran SJ, Gadkari V, and Torrelles JB.." Presented at The Ohio State University 17th Annual Denman Undergraduate Research Forum, Columbus, OH, US|USA. (May 2012)

"Human lung surfactant hydrolases alter the Mycobacterium tuberculosis cell surface influencing the human macrophage capacity to control the infection." Presented at The Ohio State University 17th Annual Denman Undergraduate Research Forum, Columbus, OH, US|USA. (May 2012)

"Determination of surfactant hydrolase content activities in alveolar lining fluid obtained from cystic fibrosis patientsbronchoalveolar lavage fluid." Presented at North American Cystic Fibrosis, Orlando, FL, US|USA. (October 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at Conference of Research Workers in Animal Diseases (CWRAD), Chicago, IL, US|USA. (December 2012)

"Lung hydrolases as a novel innate defense mechanism against M. tuberculosis infection." Presented at 2012 Public Health Preparedness for Infectious Diseases Forum, Columbus, OH, US|USA. (April 2012)

"Effects of Mycobacterium tuberculosis Cell Wall Fragments in the Host Immune Response." Presented at 7th Annual Dorothy D. Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (October 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at International PRRS Symposium (IPRRSS), Kansas City, MO, US|USA. (April 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at PHPID Annual Member Meeting, Columbus, OH, US|USA. (April 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at OARDC Annual Research Conference, Wooster, OH, US|USA. (April 2012)

"Remodeling of the Mycobacterium tuberculosis cell wall by the host lung environment." Presented at 2012 Public Health Preparedness for Infectious Diseases Forum, Columbus, OH, US|USA. (April 2012)

"Elucidation of Mycobacterium tuberculosis Rv3256c: A putative enzyme involved in the mannose donor biosynthesis pathway." Presented at Tuberculosis 2012: Biology, Pathogenesis, Intervention Strategies, Paris, FR|FRA. (September 2012)

"Human lung surfactant hydrolases alter Mycobacterium tuberculosis-Neutrophil interactions." Presented at 7th Annual Dorothy D. Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (October 2012)

"Growth-dependent changes in major cell wall components of Mycobacterium tuberculosis." Presented at 2012 Public Health Preparedness for Infectious Diseases Forum, Columbus, OH, US|USA. (April 2012)

"Consuming Consumption: Influence of the alveolar environment in Mycobacterium tuberculosis pathogenesis." Presented at Ohio Agricultural Research and Development Center Seminar Series, Wooster, OH, US|USA. (April 2012)

"Growth-dependent changes in major cell wall components of Mycobacterium tuberculosis." Presented at The Ohio State University 17th Annual Denman Undergraduate Research Forum, Columbus, OH, US|USA. (May 2012)

"Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells." Presented at 7th Annual Dorothy D. Davis Heart and Lung Research Institute Research Day, Columbus, OH, US|USA. (October 2012)

"The alveolar environment defines Mycobacterium tuberculosis-host cell interactions and the subsequent infection outcome." Presented at Host Response in Tuberculosis, Whistler, CA|CAN. (March 2013)

"Time-dependent changes in major cell wall components of Mycobacterium tuberculosis druing in-vitro growth." Presented at Tuberculosis: Understanding the Enemy, Whistler, CA|CAN. (March 2013)

"Influence of human alveolar lining fluid in Mycobacterium tuberculosis-host cell recognition." Presented at Training Research Day 2013-The Ohio State University Wexner Medical Center, Columbus, OH, US|USA. (April 2013)

"Influence of human alveolar lining fluid in Mycobacterium tuberculosis-host cell recognition." Presented at 5th Center for Microbial Interface Biology 2013 Retreat, Columbus, OH, US|USA. (April 2013)

"Elucidation of Mycobacterium tuberculosis Rv3256c: A putative enzyme involved in the mannose donor biosynthesis pathway." Presented at 5th Center for Microbial Interface Biology 2013 Retreat, Columbus, OH, US|USA. (April 2013)

"Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells." Presented at 5th Center for Microbial Interface Biology 2013 Retreat, Columbus, OH, US|USA. (April 2013)

"The role of the lung environment in Mycobacterium tuberculosis-neutrophil interactions." Presented at 5th Center for Microbial Interface Biology 2013 Retreat, Columbus, OH, US|USA. (April 2013)

"Improving the Diagnosis of TB in Guatemala." Presented at Public Health and Preparedness for Infectious Diseases (PHPID) Annual Member Meeting, Columbus, OH, US|USA. (May 2013)

"Role of human alveolar lining fluid in the host immune response to Mycobacterium tuberculosis infection." Presented at 5th Center for Microbial Interface Biology 2013 Retreat, Columbus, OH, US|USA. (April 2013)

"Poly-phosphate (Poly-P) of Campylobacter jejuni is associated with invasion and survival in human epithelial cells." Presented at 5th Center for Microbial Interface Biology 2013 Retreat, Columbus, OH, US|USA. (April 2013)

"Reduced association and altered cytokine production by monocyte-derived macrophage infected with BCG." Presented at 5th Center for Microbial Interface Biology 2013 Retreat, Columbus, OH, US|USA. (April 2013)

"Elucidation of Mycobacterium tuberculosis Rv3256c: A putative enzyme involved in the mannose donor biosynthesis pathway." Presented at Training Research Day 2013-The Ohio State University Wexner Medical Center, Columbus, OH, US|USA. (April 2013)

"Effects of the human lung environment on Mycobaterium tuberculosis pathogenesis." Presented at 20th Annual Midwest Microbial Pathogenesis Conference (MMPC 2013), Columbus, OH, US|USA. (August 2013)

"Consuming Consumption: Influence fo the Alveolar Environment in Mycobacterium tuberculosis Pathogenesis." Presented at Center for AIDS Research (CFAR), Cleveland, OH, US|USA. (February 2013)

"Evolving Concepts of Mycobacterium tuberculosis:  Pathophysiology, Immune Response, and Rapid Diagnostics." Presented at Nationwide Children's Hospital BOSS Conference, Columbus, US|USA. (March 2013)

 

Professional Activities

present 15th Congress of Catalan Medical Doctors and Biologists. Congress of Catalan Medical Doctors and Biologists. Lleida, Catalunya.
present 8th Conference of International Federation of Science Editors (IFSE). Conference of International Federation of Science Editors (IFSE). Barcelona, Catalunya.
present 24th Meeting of the Federation of European Biochemical Societies (FEBS). Meeting of the Federation of European Biochemical Societies (FEBS). Barcelona, Catalunya.
2012 Symposium on TB diagnostics in Guatemala. AIDS & Society Foundation and OSU PHPID.