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Jesse Kwiek, PhD


Staff photo

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-3256

Email: kwiek.2@osu.edu

 

Current OSU Appointment

Assistant Professor, SBS-Microbial Infectn/Immunity

 

Advising Narrative

Emily Chen was awarded an Undergraduate Research Scholarship Award in 2010.

Rachael Billock was awarded an OSU SOLAR award in 2012.

Brylan May received an NIH-diversity supplement award (R01AI084110-03S1).

Vishnu Gudimetla earned a middle author, peer-reviewed publication.

Noteworthy Graduate Narrative

My first graduate student, Surender Kumar, published two first and two middle author peer-reviewed manuscripts. He received the OSU PHPID graduate student fellowship. He was selected to give an oral presentation at the Cold Spring Harbor Retrovirus Conference and had two poster presentations at the Conference of Retroviruses and Opportunistic Infections. These are both international meetings. He did a postdoctoral fellow at the NIH (studying HIV immunology).



My second graduate student, Jessica Mates, has just published a first author manuscript and currently has one first author and one middle author publication in preparation. She presented her research as a poster at the Cold Spring Harbor Retrovirus Conference. She is scheduled to defend her dissertation in March 2014. She received first place for her poster at the OSU CMIB Research Retreat in 2013.

Academic Advising

Since I joined OSU in 2007, I have mentored two high school students, twelve undergraduate students, two graduate students, three medical students (each supported with an internal OSU fellowship [Roessler Fellowships]), two post doctoral fellows (both with PhDs in Virology), and two medical fellows. I have also served on the undergraduate honors thesis committee for six OSU students and on the PhD Advisory committee for 13 graduate students.

Undergraduate, Graduate, and Professional Courses Taught

I currently teach an average of 27 lectures per year, including one-half of the OSU undergraduate immunology class (Micro 5122), and several lectures to OSU graduate students on retrovirus biology. I am course director for Biomedical Sciences class 4810H: Select Topics in Microbiology & Immunology and co-course director for Microbiology 5122: Immunology. I have completely redone the 4810H syllabus, which now includes a service learning component (see curriculum narrative and Appendix 1). The students' service learning projects are being conducted in both Columbus and Malawi.

Biographical

I joined the faculty at the rank of Assistant Professor in the Division of Infectious Diseases, without tenure, in 2007 and I transferred my TIU to the Department of Microbial Infection and Immunity in 2011. I have a joint, 30% salaried appointment in the Department of Microbiology in the OSU College of Arts and Sciences.

Academic Advising

2009 - present Jessy Mates The Ohio State University. Department of Microbiology
2011 - present Jorge Salazar The Ohio State University.
2011 - present Rachael Billock, The Ohio State University.
2012 - present Annette Ratcliff, The Ohio State University.
2012 - present Jacob Al-Saleem The Ohio State University. Molecular, Cellular, and Developmental Biology (MCDB)
2012 - present Megan Mefford The Ohio State University.
2012 - present Nathan Dissinger The Ohio State University. Integrated Biomedical Science Graduate Program (IBGP)
2013 - present Allison Slaughter The Ohio State University. Pharmaceutics and Pharmaceutical Chemistry
2013 - present Matthew Plumb The Ohio State University. Molecular, Cellular, and Developmental Biology (MCDB)
2013 - present Nathan Titkemeier The Ohio State University. Biomedical Sciences Graduate Program
2010 Daniel Richardson The Ohio State University. Medical Student. Roessler Fellow
2010 - 2011 Vikram Shankar The Ohio State University. Maximus Scholar
2011 Emily Chen The Ohio State University. Graduated 2011. Honors Thesis in Microbiology
2011 Joanna Daigle The Ohio State University.
2011 Nadine Bowden The Ohio State University. Graduated 2011. Department of Veterinary Medicine
2011 Brylan May Thomas Worthington High School.
2010 - 2012 Surender Kumar The Ohio State University.
2011 - 2012 Claire Meeks The Ohio State University.
2011 - 2012 The Ohio State University.
2012 Rachel Kominsky The Ohio State University. Graduated 2012. Honors Thesis in Microbiology
2012 Brylan May Case Western Reserve University.
2010 - 2013 Vishnu Gudimetla The Ohio State University.
2011 - 2013 Zackary Bittinger The Ohio State University.
2012 - 2013 Christina Durchholz. The Ohio State University. Medical Student
2013 Sammy Tabbah The Ohio State University. OB/GYN Fellow
2013 Anna Askari The Ohio State University. Graduated 2013. Honors Thesis in Public Health (Political Science)
2013 Robert Easterling The Ohio State University. Graduated 2013. Honors Thesis in Microbiology
2013 John Skendelas The Ohio State University. Graduated 2013. Honors Thesis in Microbiology
 

Degrees

1995 B.S., University of Rochester

2003 Ph.D., University of Virginia

 

Editorial Activities

2008 - present AIDS Research and Human Retroviruses
2008 - present Retrovirology
2008 - present American Journal of Tropical Medicine and Hygiene
2012 - present AIDS
2013 - present Scientific Reports
 

Honors

2002 - 2004 Kirschstein National Research Service Award. UNC-Chapel Hill.
2005 - present Young Investigator Award. Conference on Retroviruses and Opportunistic Infections.
2006 - present Young Investigator Award. Conference on Retroviruses and Opportunistic Infections.
2007 - 2010 NIH Pathway to Independence Award. NICHD, K99/R00.
2011 - present Young Investigator Award. Perinatal Research Society (NIH/NICHD, R13).
 

Journal Articles

Graves PR, Kwiek JJ, Fadden P, Ray R, Hardeman K, Coley AM, Foley M, Haystead TAJ. "Discovery of novel targets of quinoline drugs in the human purine binding proteome." Molecular Pharmacology. Vol. 62, no. 6. (December 2002.): 1364-1372.

Gioeli D, Ficarro SB, Kwiek JJ, Aaronson D, Hancock M, Catling AD, White FM, Christian RE, Settlage RE, Shabanowitz J, Hunt, DF, Weber MJ. "Androgen receptor phosphorylation - Regulation and identification of the phosphorylation sites.." Journal of Biological Chemistry. Vol. 277, no. 32. (August 2002.): 29304-29314.

Abrams ET, Milner DA, Kwiek JJ, Mwapasa V, Kamwendo DD, Zeng D, Tadesse E, Lema VM, Molyneux ME, Rogerson SJ, Meshnick SR. "Risk factors and mechanisms of preterm delivery in Malawi." American Journal of Reproductive Immunology. Vol. 52, no. 2. (August 2004.): 174-183.

Kwiek JJ, Haystead TAJ, Rudolph J. "Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines." Biochemistry. Vol. 43, no. 15. (April 2004.): 4538-4547.

Yeramian P, Meshnick SR, Krudsood S, Chalermrut K, Silachamroon U, Tangpukdee N, Allen J, Brun R, Kwiek JJ, Tidwell R, Looareesuwan S. "Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections." Journal of Infectious Diseases. Vol. 192, no. 2. (July 2005.): 319-322.

Ngrenngarmlert W, Kwiek JJ, Kamwendo DD, Ritola K, Swanstrom R, Wongsrichanalai C, Miller RS, Ittarat W, Meshnick SR. "Measuring allelic heterogeneity in Plasmodium falciparum by a heteroduplex tracking assay." American Journal of Tropical Medicine and Hygiene. Vol. 72, no. 6. (June 2005.): 694-701.

Abrams ET, Kwiek JJ, Mwapasa V, Kamwendo DD, Tadesse E, Lema VM, Molyneux ME, Rogerson SJ, Meshnick SR. "Malaria during pregnancy and foetal haematological status in Blantyre, Malawi." Malaria Journal. Vol. 4, (August 2005.): 39-.

Malhotra I, Mungai P, Muchiri E, Kwiek JJ, Meshnick SR, King CL. "Congenital P. falciparum Malaria Acquired Antenatally in Kenya." Journal of Infectious Diseases. Vol. 194, no. 2. (July 2006.): 176-183.

Kwiek JJ, Mwapasa V, Milner DA, Alker AP, Miller WC, Tadesse E, Molyneux ME, Rogerson SJ, Meshnick SR. "Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi." PLoS Medicine. Vol. 3, no. 1. (January 2006.): 70-75.

Mwapasa V, Rogerson SJ, Kwiek JJ, Wilson PE, Milner D, Molyneux ME, Kamwendo DD, Tadesse E, Chaluluka E, Meshnick SR. "Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi." AIDS. Vol. 20, no. 14. (September 2006.): 1869-1877.

Kalilani L, Mofolo I, Chaponda M, Rogerson SJ, Alker AP, Kwiek JJ, Meshnick SR. "A Randomized Controlled Pilot Trial of Azithromycin or Artesunate Added to Sulfadoxine-Pyrimethamine as Treatment for Malaria in Pregnant Women." PLoS One. Vol. 2, no. 11. (November 2007.): e1166-.

Kwiek JJ, Alker AP, Wenink EC, Chaponda M, Kalilani LV, Meshnick SR. "Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections." Antimicrobial Agents and Chemotherapy. Vol. 51, no. 2. (February 2007.): 521-527.

Juliano JJ, Kwiek JJ, Cappell K, Mwapasa V, Meshnick SR. "Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi." Emerging Infectious Diseases. Vol. 13, no. 6. (June 2007.): 873-877.

Meshnick SR, Kwiek JJ, Juliano JJ. "Complexity of infection and drug resistance in human P-falciparum infections.." International Journal for Parasitology. Vol. 38, (January 2008.): S25-S25.

Kwiek JJ, Arney LA, Pederson B, Hararwa V, Mwapasa V, Meshnick SR. "Detection of Placental Microtransfusions during HIV-1 Mother-to-Child Transmission." Journal of Infectious Diseases. Vol. 197, no. 10. (May 2008.): 1378-1381.

Kwiek, J.J., Russell, E.S., Dang, K.K., Burch, C.L., Meshnick, S.R., Mwapasa, V., Swanstrom, R.. "The Molecular Epidemiology of HIV-1 Envelope Diversity During HIV-1 Subtype C Vertical Transmission in Malawian Mother-Infant Pairs." AIDS. Vol. 22, (July 2008.): 863-871.

Kwiek JJ, Mwapasa V, Muula AS, Misiri H, Alker AP, Molyneux ME, Rogerson SJ, Meshnick SR. "HIV and Syphilis Infections Among Pregnant Women in Blantyre, Malawi." Malawi Medical Journal. Vol. 20, no. 3. (July 2008.): 80-85.

Mwapasa V, Cachafeiro A, Makuta Y, Beckstead DJ, Pennell ML, Chilima B, Mwagomba B, Fiscus SA, Kwiek JJ. "Using a simplified human immunodeficiency virus type 1 p24 antigen assay to diagnose pediatric HIV-infection in Malawi." Journal of Clinical Virology. Vol. 49, no. 4. (December 2010.): 299-302.

Gay CL, Mwapasa V, Murdoch DM, Kwiek JJ, Fiscus SA, Meshnick SR, Cohen MS. "Acute HIV infection among pregnant women in Malawi." Diagnostic Microbiology and Infectious Disease. Vol. 66, no. 4. (April 2010.): 356-360.

Kumar SB, Handelman SK, Voronkin I, Mwapasa V, Janies D, Rogerson SJ, Meshnick SR, Kwiek JJ. "Different regions of HIV-1 subtype C env are associated with placental localization and in utero mother-to-child transmission.." Journal of Virology. Vol. 85, no. 14. (July 2011.): 7142-7152.

Kumar SB, Rice CE, Milner DA, Ramirez NC, Ackerman WE, Mwapasa V, Turner AN, Kwiek JJ. "Elevated cytokine and chemokine levels in the placenta are associated with in-utero HIV-1 mother-to-child transmission." AIDS. Vol. 26, no. 6. (March 2012.): 685-694.

Walton JR, Frey HA, Vandre DD, Kwiek JJ, Ishikawa T, Takizawa T, Robinson JM, Ackerman WE. "Expression of flotillins in the human placenta: potential implications for placental transcytosis." Histochemistry and Cell Biology. Vol. 139, no. 3. (March 2013.): 487-500.

Ackerman WE, Kwiek JJ. "Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women.." Journal of Nippon Medical School. Vol. 80, no. 2. (April 2013.): 90-94.

Fouda GG, Mahlokozera T, Salazar-Gonzalez JF, Salazar MG, Learn G, Kumar SB, Dennison SM, Russell E, Rizzolo K, Jaeger F, Cai, F, Vandergrift NA, Gao F, Hahn B, Shaw GM, Ochsenbauer C, Swanstrom R, Meshnick SR, Mwapasa V, Kalilani L, Fiscus S, Montefiori D, Haynes B, Kwiek JJ, Alam SM, Permar SR. "Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants." Retrovirology. Vol. 10, (January 2013.): 3-.

Mates JM, Kumar SB, Bazan J, Voronkin I, Handelman SK, Janies DJ, Kwiek JJ. "Genotypic and phenotypic heterogeneity in the U3R region of HIV-1 subtype C.." AIDS Research and Human Retroviruses. Vol. epub ahead of print, (August 2013.): PMID:23826737-.

Geraghty SR, McNamara KA, Dillon CE, Hogan JS, Kwiek JJ, Keim SA. "Buying Human Milk Via the Internet: Just a Click Away.." Breastfeeding Medicine. Vol. epub ahead of print, (August 2013.): PMID:23971685-.

Keim SA, Hogan JS, McNamara KA, Gudimetla V, Dillon CE, Kwiek JJ, Geraghty SR. "Microbial Contamination of Human Milk Purchased Via the Internet.." Pediatrics. Vol. 132, no. 5. (November 2013.): PMID: 24144714-.

Norris Turner A, Tabbah S, Mwapasa V, Rogerson SJ, Meshnick SR, Ackerman WE, Kwiek JJ. "Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women: a cohort study.." Journal of Acquired Immune Deficiency Syndrome. Vol. epub ahead of print, (July 2013.): PMID:23846560-.

 

Reference Works

January 2004 Kwiek, J; Abrams, ET; Milner, D; Mwapasa, V; Meshnick, SR."Balancing the immunological demands of pregnancy and infection." Chapel Hill. : 131
March 2004 Kwiek, J; Abrams, ET; Milner, D; Mwapasa, V; Meshnick, SR."Balancing the immunological demands of pregnancy and infection." Chapel Hill. : 211
December 2005 Purfield, A; Kwiek, J; Tidwell, RR; Meshnick, SR."Determining drug partners for the novel antimalarial compound, DB75" Chapel Hill. : 268
November 2006 Kwiek, J; Alker, AP; Wenink, EC; Kalilani, LV; Meshnick, S."Use of the quantitative MSP-1 heteroduplex tracking assay to distinguish Plasmodium falciparum reinfection from failure" Chapel Hill. : 190
November 2006 Juliano, JJ; Kwiek, J; Mwapasa, V; Meshnick, S."Minority variant pfcrt K76T mutations in Malawi suggest lurking chloroquine resistance" Chapel Hill. : 4
January 2008 Meshnick, S; Kwiek, J; Juliano, J."Complexity of infection and drug resistance in human P-falciparum infections." Chapel Hill. : S25
September 2010 Kumar SB, Handelman SK, Voronkin I, Mwapasa V, Janies D, Rogerson SJ, Meshnick SR, and Kwiek JJ."Specific changes in HIV-1 subtype C ENV are associated with placental localization and in utero mother-to-child transmission" Durham.
June 2010 Kumar S, Handelman SK, Mwapasa V, Janies D, Kwiek JJ."Perturbations in HIV-1 quasispecies dynamics during in utero mother to child transmission." Boston.
May 2011 Kumar SB, Kwiek JJ."Different Regions of HIV-1 subtype C env are associated with placental localization and in utero mother-to-child transmission, Abst #3" Cold Spring Harbor, NY.
May 2011 Handelman SK, Kumar S, Mates JM, Meshnick SR, Mwapasa V, Janies D, and Kwiek JJ."In utero mother to child transmission of HIV-1 Subtype C associated with specific changes in env and with placental localization" Athens, OH.
July 2011 Handelman S, Verducci JS, Kwiek JJ, Kumar SB, and Janies DA."PhyloPTE: Genotype/Phenotype Association with Reference to Phylogeny" Vienna, Austria.
March 2011 Handelman S, Verducci JS, Kwiek JJ, Kumar SB, Janies DA."GENPHEN: Genotype/Phenotype Association with Reference to Phylogeny" Vancouver.
June 2011 Handelman S, Verducci JS, Kwiek JJ, Kumar SB, and Janies DA."GENPHEN: Genotype/Phenotype Association with Reference to Phylogeny" Kraków, Poland.
August 2011 Kumar SB, Rice CE, Milner DA Jr., Ramirez N, Ackerman WE IV, Mwapasa V, Norris Turner A, and Kwiek JJ."Elevated Cytokine and Chemokine Levels in the Placenta Are Associate with in utero HIV-1 Mother-To-Child Transmission" Durham.
May 2011 Mates J, Kumar SB, Bazan J, Mwapasa V, Kwiek JJ."Diversity of HIV-1 subtype C U3R influences mother-to-child transmission, Abst #153" Cold Spring Harbor, NY.
August 2012 Mefford ME, Hayes AM, Kwiek JJ, Boris-Lawrie K."Striking a balance: miRNA-Mediated Silencing in HIV-1 infection" Palm Springs.
July 2013 Turner AN, Tabbah S, Mwapasa V, Rogerson SJ, Meshnick SR, Ackerman W, Kwiek JJ."Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women, #2013-A-1316-STI" Vienna.
Turner AN, Tabbah S, Mwapasa V, Rogerson SJ, Meshnick SR, Ackerman W, Kwiek JJ."Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women, Abst #2013-A-1316-STI" .

Presentations

"Molecular mechanism of vertical HIV transmission." Presented at The Burnet Institute, Laboratory Meeting, Melbourne, AU|AUS. (July 2007)

"Molecular tools to assess antimalarial treatment failure.." Presented at Walter and Eliza Hall Institute, Laboratory Meeting, Melbourne, AU|AUS. (July 2007)

"Pertubations in HIV-1 quasispecies dynamics during in utero mother to child transmission." Presented at DARPA/Department of Defense, Prophecy Teaming Day, Boston, MA. (June 2010)

"When is the best time for a science professional to start a family?." Presented at OSU Integrated Biomedical Science Graduate Program, . (January 2010)

"HIV/AIDS in sub-Saharan Africa." Presented at OSU African Youth League, . (January 2010)

"Careers in Research." Presented at OSU Biomedical Sciences, . (January 2010)

"The HIV pandemic." Presented at OSU Honors Day, Recruitment Session, . (January 2010)

"Host proteins required for HIV-1 replication." Presented at Duke University, Department of Pharmacology and Cancer Biology, Haystead Research Group, . (August 2011)

"Mechanisms of HIV-1c Mother-to-Child Transmission." Presented at Ethiopian Society of Tropical and Infectious Disease, Addis Ababa, Ethiopia, . (December 2012)

"The Global Health Summit on HIV/AIDS." Presented at OSU Global Health Initiative, . (January 2012)

"Personal Perspectives on Global Health Research." Presented at OSU Buckeyes Without Borders, . (January 2012)

"HIV evolution." Presented at OSU Microbiology Club, . (January 2012)

"Vertical HIV transmission." Presented at The Research Institute at Nationwide Children's Hospital, Bench to Outcomes Seminar Series (BOSS), Columbus. (June 2012)

"HIV-1 evolution and vertical HIV transmission." Presented at University of Toledo, Department of Medical Microbiology and Immunology, Toledo. (May 2012)

"Molecular Mechanism of vertical HIV transmission." Presented at Case Western Reserve University, World Health Interest Group and The Infectious Diseases & HIV Medicine Host Defense Joint Seminar Series, . (August 2012)

"HIV-associated adverse birth outcomes." Presented at OSU Center for Women's Health - Women's Health Initiative, Research Collaboration Seminar, . (January 2013)

"HIV-associated Low Birth Weight." Presented at Case Western Reserve Center for AIDS Research Conference, Cleveland, Ohio. (August 2013)

 

Professional Activities

present African Society for Laboratory Medicine, 1st ASLM International Conference.
present Ethiopian Society of Tropical and Infectious Disease Conference.
present AIDS Molecular and Cellular Biochemistry (AMCB) Study Section. National Institutes of Health.
present South African Medical Research Council (MRC).
present Special Emphasis Panel (ZHD1 DSR-A), "Prevention of HIV transmission and acquisition through a better understanding of reproductive health.". National Institutes of Health (NICHD).
present Consultant. Global Science Forum of the Organisation for Economic Co-operation and Development (OECD).
2009 - present Seed Grant Program. American Medical Association Foundation.
 

Unpublished Works

Handelman, S.K., Aaronson, J.M., Kwiek, J.J., Verducci, J.S., Janies, D.. Phylogeny with Path to Event for Viruses (PhyloPTE/V): Robust efficient association detection for qualitative traits on phylogenies. June 2013.

Alwarah, Y, Ratcliff, A, Kulkarni, M., Hughes, P., Matous, J., Haystead, T., Kwiek, J.J.. Inhibitors of Fatty Acid Biosynthesis efficiently block HIV-replication.

Kulkarni, M., Hughes, P., Matous, J., Haystead, T., Kwiek, J.J.. Identification of HSP-90 inhibitors that block HIV replication.