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Bradford S. McGwire, MD, PhD


Staff photo

410 W 10th Ave
Columbus, OH 43210

Phone: (614) 292-3226

Email: mcgwire.2@osu.edu

 

Current OSU Appointments

Assistant Professor, Infectious Diseases

Physician, FGP-Infectious Diseases

Assistant Professor, SBS-Microbial Infectn/Immunity

 

Partnership Narrative

1) Developed informal partnership with Helix Biomedix which is an antimicrobial peptide company in Bothell, WA. They have donated several antimicrobial peptides to the lab for anti-parasitic testing.



2) I have an informal partnership with Pfizer who donated the anti-fungal compound voriconazole (VFEND) for anti-leishmanial testing. This has been published in Parasitology Research in 2013 (see publication list).

Published Works

The main thrust of my publications concern studies on the cellular and molecular biology of the pathogenic trypanosomatid protozoa (Leishmania, Trypanosoma cruzi and Trypanosoma brucei). In the last several years they have have dealt with the interactions of these parasites with antimicrobial peptides (innate immune system effectors). The results have implications for the role of AMPs in the natural control of parasite infection in the infected host (insect and mammalian) as well as for the development of AMPs as chemotherapeutic agents. We have identified two key AMP resistance mechanisms of parasites (gp63 metelloprotease expression in Leishmania and Cyp19 expression in T. cruzi). I have published some assorted reviews and chapters on aspects of parasite biology and chemotherapeutics. I have also published a few clinical case reports.

Research Funding

During my time at OSU I have been awarded 3 grants; 2 from the American Heart Association (Beginning Grant-in-Aid and Scientist Development Grant) and an internal award from OSU (Davis Bremer). I have written numerous NIH (R01 and R21), NSF, AHA grants as well as a variety of brants to other agencies such as the Burroughs Wellcome Fund. I have been awarded a 2013-2014 Fulbright Scholar Award to develop collaborations in Ecuador on Chagas disease. Most recently I was invited to submit a fill proposal to the NSF base on my recent work on Chagas. This is based on the "high quality" score on a pre-proposal (22% of 288 proposals were invited). I also recieved funding through the OSU-FAPSEP(Brazil) Collaboration to fund work with my collaborator in Brazil from 2014-2015 on T. cruzi signalling.

Academic Advising

Periodically I advise medical students, residents and fellows in training about career options in medicine. I draw upon my personal experience in clinical medicine and in basic and translational science in order to discuss opportunities they meay wish to consider.

Academic Advising

2012 - present Ken Woods The Ohio State University.
2012 - present Bonnie Prokesch The Ohio State University.
2012 - present Sid Hublikar The Ohio State University.
2013 - present Patricia Salvador The Ohio State University.
2013 - present Muhammed Ali The Ohio State University.
2013 - present Vidhya Chandrasekaran The Ohio State University.
2004 - 2005 Jamal Horani The Ohio State University. Graduated 2005.
2004 - 2006 Jeremy Young The Ohio State University. Graduated 2006.
2004 - 2006 Niveditha Reddy The Ohio State University. Graduated 2006.
2007 Kimberly Newkirk The Ohio State University.
2006 - 2008 Raed Khairy The Ohio State University. Graduated 2008.
2006 - 2008 Nikkiya Fraser The Ohio State University. Graduated 2008.
2007 - 2008 Eric Jones The Ohio State University. Graduated 2008.
2007 - 2009 Mark Lustberg The Ohio State University. Graduated 2009.
2007 - 2009 Jose Bazan The Ohio State University. Graduated 2009.
2008 - 2009 Tulasi Gude, The Ohio State University.
2008 - 2010 Rachel Demita The Ohio State University. Graduated 2010.
2008 - 2010 Gabriel Galang The Ohio State University. Graduated 2010.
2008 - 2010 Legesse Mekonnen The Ohio State University. Graduated 2010.
2009 - 2010 Alissa Ackelson The Ohio State University. Graduated 2010.
2009 - 2010 Madhuri Sopirala The Ohio State University. Graduated 2010.
2009 - 2011 Richard Bakker The Ohio State University. Graduated 2011.
2009 - 2011 Doug Haas The Ohio State University. Graduated 2011.
2009 - 2011 Christina Liscynesky The Ohio State University. Graduated 2011.
2011 Hannah Cummings The Ohio State University.
2005 - 2012 Manjusha Kulkarni The Ohio State University.
2010 - 2012 Satish Sarvepalli The Ohio State University. Graduated 2012.
2010 - 2012 Julian Goodman The Ohio State University. Graduated 2012.
2010 - 2012 Foad Abandeh The Ohio State University. Graduated 2012.
2011 - 2013 Robert Leininger The Ohio State University. Graduated 2013.
2011 - 2013 Amber Vasquez The Ohio State University. Graduated 2013.
 

Certifications

2006 - present Board Certification: American Board of Internal Medicine
2007 - present Board Certification: American Board of Internal Medicine
1997 - 2004 MD: State Medical Board Illinois
2004 - 2017 MD: State Medical Board of Ohio
 

Chapters in Books

Bradford S. McGwire, David M. Engman. "American Trypanosomiasis." In Medical Parasitology. Edited by Abhay R. Satoskar, Gary L. Simon, Peter J. Hotez, Moriya Tsuji. -. Austin, TX: Landes Bioscience, January 2010.

McGwire, BS. "Treatment modalities for cutaneous and visceral leishmaniasis." In Pathogenesis of Leishmaniasis: New Developments in Research. Edited by Satoskar, AS, Durvasula, R.. -.

 

Clinical Services

07/01/2004 Attending Physician (Outpatient Infectious Disease Clinic (McCampbell Hall and previously Cramblett Hall))
07/01/2004 Attending Physician (Inpatient ID service-Main Hospital)

Degrees

1987 B.S., California State Polytechnic University

1995 Ph.D., University of Health Sciences/Chicago Medical School

1997 M.D., University of Health Sciences/Chicago Medical School

 

Editorial Activities

2004 - present Research in Microbiology
2004 - present Biochemical Journal
2004 - present Antimicrobial Agents and Chemotherapy
2004 - present Annals of Clinical Microbiology and Antimicrobials
2004 - present American Journal of Tropical Medicine & Hygiene
2004 - present Microbes and Infection
2004 - present Journal of Infectious Diseases
2004 - present Journal of Clinical Microbiology
2004 - present Journal of Bacteriology
2004 - present Clinical Infectious Diseases
2004 - present Biology of the Cell
2004 - present Infection and Immunity
2004 - present Experimental Parasitology
2004 - present ACTA Tropica
2004 - present Eukaryotic Cell
2004 - 2011 Parasitology
2004 - 2011 Biochimie
2005 - present European Journal of Protistology
2005 - present Protist
2005 - present Molecular Microbiology
2006 - present Molecular and Biochemical Parasitology
2007 - present PLOS-Neglected Tropical Diseases
2011 - present Folia Parasitologia
2011 - present Open Journal of Medical Microbiology
2011 - present PLOS-One
 

Honors

1986 - 1987 Scholar Exchange Program: Uppsala University, Sweden. California State University-Pomona.
1989 - 1990 Medical Student Research Training Fellowship.
1991 - 1995 Graduate Student Teaching Assistantship.
1993 B.H. Travel Award.
1995 Best student poster presentation.
2000 - 2002 Physician-Scientist Postdoctoral Fellowship. American Heart Association.
2013 - 2014 Fulbright Scholar Award. Fulbright Commission of the US.
 

Journal Articles

McGwire, B. S.. "Review of Nucleic acid hybridization: A new tool for the diagnosis of infectious disease.." STUDENT DOctor. Vol. 10, no. 1. (January 1988.): 20-.

Stipkovits, L; Belak, S; McGwire, B, S; Ballagi-Pordany, A; Santha, M. "Rapid identification of Mycoplasma gallisepticum using a simple method of nucleic acid hybridization.." Mol. Cell. Probes. Vol. 2, no. 4. (January 1988.): 339-44.

Morein, B; Belak, S; Soos, T; Rusvai, M; McGwire, B, S; Bognar, K. "Iscom of viral envelope proteins protects against Aujeszky's disease.." Vet. Microbiol.. Vol. 20, no. 2. (January 1989.): 143-54.

Sears, A, E; McGwire, B, S; Roizman, B. "Infection of polarized MDCK cells with herpes simplex virus 1: two asymmetrically distributed cell receptors interact with different viral proteins.." Proc. Nat. Acad. Sci. USA. Vol. 88, no. 12. (January 1991.): 5087-91.

Mensa-Wilmot, K; LeBowitz, J, H; Chang, K, P; al-Qahtani, A; McGwire, B, S; Tucker, S; Morris, J C. "A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways.." J. Cell Biol.. Vol. 124, no. 6. (January 1994.): 935-47.

Mensa-Wilmot K, LeBowitz JH, Chang KP, al-Qahtani A, McGwire BS, Tucker S, Morris JC.. "GPI phospholipase C from Trypanosoma brucei causes a GPI-negative phenotype in Leishmania major: I. Implications for GPI-negative mammalian cells; II. Compartmentalization of two GPI biosynthetic pathways.." Brazil. J. of Med. Biol. Res.. Vol. 27, no. 2. (January 1994.): 177-84.

McGwire, B; Chang, K P. "Genetic rescue of surface metalloproteinase (gp63)-deficiency in Leishmania amazonensis variants increases their infection of macrophages at the early phase.." Mol. Biochem. Parasit.. Vol. 66, no. 2. (January 1994.): 345-7.

Singh,S; McGwire,B,S; Chang,K,P. "KINETOPLAST AND NUCLEAR-DNA POLYMORPHISM OF VISCERAL LEISHMANIA ISOLATES FROM NORTHEASTERN INDIA." JOURNAL OF PROTOZOOLOGY RESEARCH. Vol. 5, no. 1. (January 1995.): 27-32.

Brittingham, A; Morrison, C, J; McMaster, W, R; McGwire, B, S; Chang, K, P; Mosser, D M. "Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis.." J. Immunol.. Vol. 155, no. 6. (January 1995.): 3102-11.

Chakrabarty, R; Mukherjee, S; Lu, H, G; McGwire, B, S; Chang, K, P; Basu, M K. "Kinetics of entry of virulent and avirulent strains of Leishmania donovani into macrophages: a possible role of virulence molecules (gp63 and LPG).." J. Parasitol.. Vol. 82, no. 4. (January 1996.): 632-5.

McGwire, B, S; Chang, K P. "Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage,." J. Biol. Chem.. Vol. 271, no. 14. (January 1996.): 7903-9.

Mensa-Wilmot, K; Garg, N; McGwire, B, S; Lu, H, G; Zhong, L; Armah, D, A; LeBowitz, J, H; Chang, K P. "Roles of free GPIs in amastigotes of Leishmania.." Mol. Biochem. Parasit.. Vol. 99, no. 1. (January 1999.): 103-16.

Brittingham, A; Chen, G; McGwire, B, S; Chang, K, P; Mosser, D M. "Interaction of Leishmania gp63 with cellular receptors for fibronectin.." Infect. Immun.. Vol. 67, no. 9. (January 1999.): 4477-84.

Chang KP, McGwire BS.. "Molecular determinants and regulation of Leishmania virulence.." Kinetoplastid Biol Dis.. Vol. 1, no. 1. (January 2002.): 1-.

McGwire, Bradford, S; O'Connell, William, A; Chang, Kwang-Poo; Engman, David M. "Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence.." J. Biol. Chem.. Vol. 277, no. 11. (January 2002.): 8802-9.

McGwire, Bradford, S; Chang, Kwang-Poo; Engman, David M. "Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63.." Infect. Immun.. Vol. 71, no. 2. (January 2003.): 1008-10.

McGwire,B,S; Olson,C,L; Tack,B,F; Engman,D,M. "Killing of African trypanosomes by antimicrobial peptides." JOURNAL OF INFECTIOUS DISEASES. Vol. 188, no. 1. (July 2003.): 146-152.

Chang K.-P, Reed S. G., McGwire B. S, Soong L.. "Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity.." ACTA Tropica. Vol. 85, no. 3. (January 2003.): 375-390.

Young, Jeremy, D and McGwire, Bradford S. "Infliximab and reactivation of cerebral toxoplasmosis.." The New England journal of medicine. Vol. 353, no. 14. (January 2005.): 1530-1; discussion 1530.

Kulkarni, Manjusha, M; McMaster, W Robert; Kamysz, Elzbieta; Kamysz, Wojciech; Engman, David, M; McGwire, Bradford S. "The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing.." Mol. Microbiol.. Vol. 62, no. 5. (January 2006.): 1484-97.

Kulkarni, MM, Jones, EA, McMaster, WR, McGwire, BS. "Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation." Infect Immun. Vol. 76, no. 4. (April 2008.): 1738-1747.

Kulkarni,Manjusha,M; Olson,Cheryl,L; Engman,David,M; McGwire,Bradford,S. "Trypanosoma cruzi GP63 Proteins Undergo Stage-Specific Differential Posttranslational Modification and Are Important for Host Cell Infection." INFECTION AND IMMUNITY. Vol. 77, no. 5. (May 2009.): 2193-2200.

Kulkarni MM, McMaster WR, Kamysz W, McGwire BS. "Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicity.." J. Biol. Chem.. Vol. 284, no. 23. (January 2009.): 15496-15504.

McGwire,Bradford,S; Kulkarni,Manjusha,M. "Interactions of antimicrobial peptides with Leishmania and trypanosomes and their functional role in host parasitism." EXPERIMENTAL PARASITOLOGY. Vol. 126, no. 3. (November 2010.): 397-405.

Maric,Danijela; McGwire,Bradford,S; Buchanan,Kathryn,T; Olson,Cheryl,L; Emmer,Brian,T; Epting,Conrad,L; Engman,David,M. "Molecular Determinants of Ciliary Membrane Localization of Trypanosoma cruzi Flagellar Calcium-binding Protein." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 38. (September 2011.): 33109-33117.

Kulkarni MM, Barbi J, McMaster WR, Gallo RL, Satoskar AR, McGwire BS. "Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection.." Cell. Microbiol.. Vol. 13, no. 6. (January 2011.): 913-923.

Marr,Alexandra,K; McGwire,Bradford,S; McMaster,W,Robert. "Modes of action of Leishmanicidal antimicrobial peptides." FUTURE MICROBIOLOGY. Vol. 7, no. 9. (September 2012.): 1047-1059.

McGwire,Bradford; Marr,Brendan; Zhou,Xiao-Ping; Ayers,Leona. "Iliopsoas coccidioidomycotic abscess with associated intra-abdominal extension in an immunocompetent patient.." BMJ Case Reports. Vol. 2012, (January 2012.): 1-3.

Kulkarni MM, Karafova A, Kamysz W, Schenkman S, Pelle R, McGwire BS.. "Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity.." J Biol Chem.. Vol. 288, no. 12. (February 2013.): 8772-84.

Kulkarni MM, Reddy N, Gude T, McGwire BS.. "Voriconazole suppresses the growth of Leishmania species in vitro.." Parasitol Res.. Vol. 112, (February 2013.): 2095–2099-.

McGwire, BS. "Acute abdominal pain and diarrhoea in healthy adult." British Medical Journal Case Reports. Vol. doi: 10.1136/bcr-2013-009441, (June 2013.): doi: 10.1136/bcr-2013.

McGwire, B. "Abdominal pain in a healthy adult." BMJ Case Reports. Vol. 2013, (June 2013.): 1-2.

McGwire, BS and Satoskar, AR.. "Leishmaniasis: clinical syndromes and treatment." Quarterly J Med.. Vol. 107, no. 1. (January 2014.): 7-14.

McGwire, BS, Satoskar, AR. "Leishmaniasis: clinical syndromes and treatment." Quarterly Journal of Medicine. Vol. 107, no. 1. (January 2014.): 7-14/doi:10.1093/qjmed/hct116.

Walker, D, Gupta, G, McGwire, BS, Drew, M, Satoskar, AR.. "Molecular mechanisms of invasion by parasitic protozoa." Cellular and Molecular Life Sciences. Vol. 71, no. 7. (April 2014.): 1245-63.

Kulkarni, MM., Karafova, A, Kamysz, W, McGwire, BS. "Design of protease-resistant pexiganan enhances antileishmanial activity." Parasitology Research. -.

 

Inventions and Patents

Bradford S. McGwire. "Novel antibacterial protein from Trypanosoma cruzi." OSU. Filed September 2010.

Bradford S. McGwire. "Antimicrobial activity secreted from entomopathogenic bacteria." OSU. Filed September 2010.

 

Presentations

"Host origin of replication in the genome of HSV-1.." Presented at VIIIth International Congress of Virology, . (January 1990)

"Studies on herpes simplex virus latency.." Presented at Howard Hughes Medical Institute - National Institutes of Health, . (January 1990)

"Extrachromosomal genetics in trypanosomatid biology." Presented at VIIIth Meeting of the Brazilian Society of Protozoology, . (January 1992)

"Leishmania in medicine and research." Presented at ACCA biology seminar series, . (January 1993)

"Functional analysis of Leishmania metalloproteinase (gp63) by site-specific mutagenesis.." Presented at University of Health Science - Dept of Microbiology, . (January 1993)

"Functional analysis of Leishmania metalloproteinase by genetic modifications.." Presented at University of Health Science - Research Poster Session, . (January 1993)

"Extrachromosomal expression of Leishmania gp63 genes and their site specific mutants.." Presented at International Congress of Parasitology, . (January 1994)

"Structure, function and evolution of the ecto=metalloprotease (gp63) of Leishmania. Molecular analysis of wildtype genes and their site-specific mutants.." Presented at University of Health Science - Research Poster Session, . (January 1995)

"Posttranscriptional regulation of leishmanial ecto-metalloprotease (gp63) expression and activity in the parasitism of macrophages.." Presented at Calandra Research Forum - Department of Pathology, . (January 1995)

"Molecular genetic analysis of leishmanial ecto-metalloprotease (gp63): Posttranscriptional regulation of enzyme expression and activity in the paraitism of macrophages.." Presented at University of Health Science - Dept of Microbiology, . (January 1995)

"Functional analysis of an HEXXH metalloprotease (gp63) by site-sp[ecific mutagenesis.." Presented at University of Health Science - Research Poster Session, . (January 1996)

"Posttranscriptional regulation of Leishmania ectometalloprotease (gp63) gene expression via concerted interaction of putative elements in the 5' - 3' flanking regions.." Presented at Molecular Parasitology Meeting, . (January 2000)

"Leishmania gp63 is released extracellularly via two different mechanisms." Presented at Molecular Parasitology Meeting, . (January 2000)

"Expression of Trypanosoma cruzi FCaBP in Leishmania reveals a conserved mechanism for flagellar protein lozalization." Presented at 3rd Internet Conference on Salvarian Trypanosomes and Trypanosomatids, . (January 2000)

"Inactivation of gp63proteolytic activity by sire specific mutation diminishes the intramacrophage survival of Leishmania amazonensis." Presented at 3rd Internet Conference on Salvarian Trypanosomes and Trypanosomatids, . (January 2000)

"Cell Surface autoproteolytic and secretory release of leishmanial metalloprotease (gp 63)." Presented at WorldLeish2 Meeting, . (January 2001)

"Indentification of surface localized gp63 homologues in all life stages of Trypanosoma cruzi." Presented at Molecular Parasitology Meeting, . (January 2001)

"Dissection and conservation of the mechanism of flagellar localization of Trypanosoma cruzi FCaBP." Presented at Molecular Parasitology Meeting, . (January 2001)

"Release of gp63 and diminished in vitro early phase infection of a GPI - lacking mutant from Leishmania mexicana." Presented at WorldLeish2 Meeting, . (January 2001)

"Indentification of surface localized T. cruzi gp63 homologues in all life stages and is involved in host parasitism." Presented at Molecular Parasitology Meeting, . (January 2003)

"Killing Of African trypanosomes by antimicrobial peptides.." Presented at 11th International Infectious Diseases, . (January 2004)

"Indentification of surface localized T. cruzi gp63 homologues in all life stages and is involved in host parasitism." Presented at 11th International Infectious Diseases, . (January 2004)

"Antileishmanial/trypanosomal activities of antimicrobial peptides.." Presented at Gordon Conference, Antimicrobial Peptides, . (January 2005)

"Membrane active peptieds as potential anti-parasite therapeutics." Presented at 45th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), New Orleans, LA. (January 2005)

"Antimicrobial peptide resistance by the parasitic protozoan Leishmania: a novel function for the surface metalloprotease and its implications for the design of surface active chemotherapeutics." Presented at 4th Annual OSUMC Research Day, Columbus, OH. (January 2005)

"Antimicrobial peptide (AMP)-Leishmania interactions:importance of the parasite surface-protease in evasion of AMP-induced apoptotic cell death and a novel role for AMPs in parasite pathogenesis." Presented at Midwest Microbial Pathogenesis Conference, Cincinnati, OH. (January 2006)

"Parasite surface-metalloprotease protects against antimicrobial peptide induced apoptotic killing of Leishmania." Presented at Dept. of Microbiology and Immunology, Chicago, IL, US|USA. (January 2006)

"Rapid and extensive metallo and cysteine proteolytic degradation of the extracellular matrix proten, fibroectin by insect and intracellular forms of Leishmania contributes to enhanced macrophage infection.." Presented at Midwest Microbial Pathogenesis Conference, Cincinnati, OH. (January 2006)

"Antimicrobial peptide “sensing� by the pathogenic protozoan Trypanosoma cruzi leads to differentiation of insect-stage parasites to infectious forms." Presented at CMIB Retreat at OSUMC, Columbus, OH. (January 2007)

"Antimicrobial peptide “sensing� by the pathogenic protozoan Trypanosoma cruzi leads to differentiation of insect-stage parasites to infectious forms." Presented at Midwest Microbial Pathogenesis Conference, Chicago, IL. (January 2007)

"Differential induction of apoptotic and non-apoptotic death of Leishmania by distinct classes of antimicrobial peptides." Presented at CMIB Retreat at OSUMC, Columbus, OH. (January 2007)

"Differential induction of apoptotic and non-apoptotic death of Leishmania by distinct classes of antimicrobial peptides." Presented at Kinetoplastid Molecular Cell Biology Meeting, Wods Hole, MA. (January 2007)

"Fibronectin binding and metallo- and cysteine proteolytic degradation by Leishmania contributes to parasite infectivity." Presented at CMIB Retreat at OSUMC, Columbus, OH. (January 2007)

"Fibronectin binding and metallo- and cysteine proteolytic degradation by Leishmania contributes to parasite infectivity." Presented at Kinetoplastid Molecular Cell Biology Meeting, Woods Hole, MA. (January 2007)

"Characterization of a protein from Trypanosoma cruzi as a potential novel anti-microbial compound." Presented at CMIB Retreat at OSUMC, Columbus, OH. (January 2008)

"Antimicrobial Peptides in Medicine and Disease." Presented at Internal Medicine Grand Rounds, Columbus, OH, US|USA. (January 2008)

"Characterization of a protein from Trypanosoma cruzi as a potential novel anti-microbial compound." Presented at 7th Annual OSUMC Research Day, Columbus, OH. (January 2008)

"Differential induction of apoptotic death of Leishmania by antimicrobial peptides results from calcium-dependent mitochondrial toxicity." Presented at World Congress on Leishmaniasis, Lucknow, IN|IND. (January 2009)

"The murine cathelicidin-related antimicrobial peptide, CRAMP, influences control of cutaneous leishmaniasis; 4th World congress on Leishmaniasis." Presented at World Congress on Leishmaniasis, Lucknow, IN|IND. (January 2009)

"The murine cathelicidin-related antimicrobial peptide, CRAMP, influences control of cutaneous leishmaniasis." Presented at Midwest Microbial Pathogenesis Conference, West Lafayette, IN. (January 2009)

"Novel anti-microbial proteins against MRSA and Francisella novicida." Presented at GLRCE Regional Meeting, Chicago, IL. (January 2010)

"Antimicrobial peptide “sensing� by the pathogenic protozoan Trypanosoma cruzi leads to differentiation of insect-stage parasites to infectious form." Presented at Midwest Microbial Pathogenesis Conference, St. Louis, MO. (January 2010)

"Secreted trypanosomal cyclophilin mediates host antimicrobial peptide evasion promoting parasite survival and infectivity." Presented at CMIB Retreat at OSUMC, Columbus, OH. (January 2011)

"The murine cathelicidin-related antimicrobial peptide, cramp, influences control of cutaneous leishmaniasis." Presented at 4th Annual T2C Conference on Inflammation Tissue Injury and wound repair, Columbus, OH. (January 2011)

"Secreted trypanosome cyclophilin mediates calcineurin-based sensing and evasion of insect defense peptide." Presented at 2nd Annual Midwest Neglected Infectious Disease Meeting, . (August 2012)

"Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces calcineurin activation and infectivity." Presented at Cyclophilins and other Foldases: Cell Signaling Catalysts and Drug Targets, Halle, DE|DEU. (September 2013)

 

Professional Activities

2004 - present Infectious Disease Clinical Consultation. OSU Hospitals.
2004 - present Ad Hoc Reveiwer. Multiple scientific journals.
2004 - present Inpatient Infectious Diseases Service. OSU Main Hospital.
2008 - present Grant Review. American Heart Association.
2008 - present German Research Foundation.
2009 - present Grant Reviewer. Medical Research Council (British).
2009 - present Grant Reveiwer. Portuguese Foundation for Science and Technology.
2011 - present Parasitiology Journal/Research Club.
2013 - present Grant Reviewer. Department of Defense.
 

Unpublished Works

Kulkarni, M, Varikuti, S, Satoskar, AS, McGwire, BS. Stat-1 is critical to the control of Trypanosoma cruzi infection. April 2014.